keyword
https://read.qxmd.com/read/38373851/long-term-cardiovascular-risks-and-the-impact-of-statin-treatment-on-socioeconomic-inequalities-a-microsimulation-model
#21
JOURNAL ARTICLE
Runguo Wu, Claire Williams, Junwen Zhou, Iryna Schlackow, Jonathan Emberson, Christina Reith, Anthony Keech, John Robson, Jane Armitage, Alastair Gray, John Simes, Colin Baigent, Borislava Mihaylova, Jane Armitage, Colin Baigent, Elizabeth Barnes, Lisa Blackwell, Rory Collins, Kelly Davies, Jonathan Emberson, Jordan Fulcher, Heather Halls, William G Herrington, Lisa Holland, Anthony Keech, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, David Preiss, Christina Reith, John Simes, Kate Wilson, Michael Blazing, Eugene Braunwald, James de Lemos, Sabina Murphy, Terje R Pedersen, Marc Pfeffer, Harvey White, Stephen Wiviott, Michael Clearfield, John R Downs, Antonio Gotto, Stephen Weis, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Terje R Pedersen, David Gordon, Barry Davis, Curt Furberg, Richard Grimm, Sara Pressel, Jeffrey L Probstfield, Mahboob Rahman, Lara Simpson, Michael Koren, Björn Dahlöf, Ajay Gupta, Neil Poulter, Peter Sever, Hans Wedel, Robert H Knopp, Stuart Cobbe, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Roland Schmieder, Faiez Zannad, D John Betteridge, Helen M Colhoun, Paul N Durrington, John Fuller, Graham A Hitman, Andrew Neil, Eugene Braunwald, Barry Davis, C Morton Hawkins, Lemuel Moyé, Marc Pfeffer, Frank Sacks, John Kjekshus, Hans Wedel, John Wikstrand, Christoph Wanner, Vera Krane, Maria Grazia Franzosi, Roberto Latini, Donata Lucci, Aldo Maggioni, Roberto Marchioli, Enrico B Nicolis, Luigi Tavazzi, Gianni Tognoni, Jackie Bosch, Eva Lonn, Salim Yusuf, Jane Armitage, Louise Bowman, Rory Collins, Anthony Keech, Martin Landray, Sarah Parish, Richard Peto, Peter Sleight, John Jp Kastelein, Terje R Pedersen, Robert Glynn, Antonio Gotto, John Jp Kastelein, Wolfgang Koenig, Jean MacFadyen, Paul M Ridker, Anthony Keech, Stephen MacMahon, Ian Marschner, Andrew Tonkin, John Shaw, John Simes, Harvey White, Patrick W Serruys, Genell Knatterud, Gerard J Blauw, Stuart Cobbe, Ian Ford, Peter Macfarlane, Chris Packard, Naveed Sattar, James Shepherd, Stella Trompet, Eugene Braunwald, Christopher P Cannon, Sabina Murphy, Rory Collins, Jane Armitage, Louise Bowman, Richard Bulbulia, Richard Haynes, Sarah Parish, Richard Peto, Peter Sleight, Pierre Amarenco, K Michael Welch, John Kjekshus, Terje R Pedersen, Lars Wilhelmsen, Philip Barter, Antonio Gotto, John LaRosa, John Jp Kastelein, James Shepherd, Stuart Cobbe, Ian Ford, Sharon Kean, Peter Macfarlane, Chris Packard, Michele Roberston, Naveed Sattar, James Shepherd, Robin Young, Hiroyuki Arashi, Robert Clarke, Marcus Flather, Shinya Goto, Uri Goldbourt, Jemma Hopewell, G Kees Hovingh, George Kitas, Connie Newman, Marc S Sabatine, Gregory G Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamamguchi
BACKGROUND: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. AIM: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. DESIGN AND SETTING: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys...
February 19, 2024: British Journal of General Practice
https://read.qxmd.com/read/38367153/oxygen-extraction-fraction-oef-values-and-applications-in-neurological-diseases
#22
REVIEW
Joshua Engle, Parastoo Saberi, Paul Bain, Asad Ikram, Magdy Selim, Salil Soman
One of the goals of this systematic review is to provide a meta-analysis-derived mean OEF of healthy volunteers. Another aim of this study is to indicate the OEF ranges of various neurological pathologies. Potential clinical applications of OEF metrics are presented. Peer-reviewed studies reporting OEF metrics derived from computed tomography (CT)/positron emission tomography (PET) and/or magnetic resonance imaging (MRI) were considered. Databases utilized included MEDLINE, PubMed, EMBASE, Web of Science, and Google Scholar...
February 17, 2024: Neurological Sciences
https://read.qxmd.com/read/38366164/network-analysis-of-depression-cognitive-functions-and-suicidal-ideation-in-patients-with-diabetes-an-epidemiological-study-in-iran
#23
JOURNAL ARTICLE
Mojgan Daneshmand, Mahsa Kashefizadeh, Masoumeh Soleimani, Shaghayegh Mirzaei, Natalie Tayim
AIMS: The main aim of this study was to assess the prevalence of suicidal ideation and previous suicide attempts among Iranian patients diagnosed with Type-1 diabetes (T1D) and Type-2 diabetes (T2D). Additionally, the study sought to estimate the network structure of depressive symptoms and cognitive functions. METHODS: 1073 patients participated in the current study. We used Patient Health Questionnaire-9 (PHQ-9), Ask Suicide-Screening Questionnaire, diabetes-related factors, and a battery of cognitive functions tasks to estimate network structures...
February 16, 2024: Acta Diabetologica
https://read.qxmd.com/read/38365767/prevention-of-neointimal-hyperplasia-after-coronary-artery-bypass-graft-via-local-delivery-of-sirolimus-and-rosuvastatin-network-pharmacology-and-in-vivo-validation
#24
JOURNAL ARTICLE
Ji-Yeon Ryu, Eui Hwa Jang, JiYong Lee, Jung-Hwan Kim, Young-Nam Youn
BACKGROUND: Coronary artery bypass graft (CABG) is generally used to treat complex coronary artery disease. Treatment success is affected by neointimal hyperplasia (NIH) of graft and anastomotic sites. Although sirolimus and rosuvastatin individually inhibit NIH progression, the efficacy of combination treatment remains unknown. METHODS: We identified cross-targets associated with CABG, sirolimus, and rosuvastatin by using databases including DisGeNET and GeneCards...
February 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38363940/osteotomy-for-treating-knee-osteoarthritis-from-2012-to-2023-bibliometric-analysis-and-global-trends
#25
JOURNAL ARTICLE
Wenyuan Hou, Fangjun Xiao, Peng Peng, Mincong He, Qiushi Wei
BACKGROUND: Numerous surgical interventions are available for the treatment of knee osteoarthritis (KOA). In recent years, knee-preserving surgery, specifically osteotomy, has gained significant attention from patients, particularly those who are young and physically active, as it not only effectively alleviates pain but also preserves bone integrity, thereby allowing for potential future joint replacement. This study aims to comprehensively analyze the global application trends of osteotomy for KOA and identify the current research hotspots...
February 16, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38361860/serum-gamma-glutamyl-transferase-level-as-a-risk-factor-in-acute-stroke
#26
JOURNAL ARTICLE
Quazi M Ismail, Manoj K Prasad, Sujeet Marandi, Rishi T Guria, Ajit Dungdung
BACKGROUND: Worldwide stroke is the second major cause of mortality and the fourth prominent cause of disease load after coronary heart disease and all types of malignancy. Greater than 3/4th of these cases are in low-priced and middle-priced nations. Several epidemiological studies have shown that alcohol consumption is a risk factor for stroke. The correlation between alcohol consumption and stroke involves various processes. For excessive alcohol consumption, GGT (gamma glutamyl transferase) is used as a marker...
December 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38356575/examining-the-influence-of-financial-inclusion-on-investment-decision-a-bibliometric-review
#27
REVIEW
Eko Pranajaya, Mohammad Benny Alexandri, Arianis Chan, Bambang Hermanto
This study delves into the contemporary landscape of potential financial inclusion in investment decision-making, leveraging bibliometric research methods. Analyzing 161 publications from the Scopus database (2006-2023), the authors employ performance analysis and scientific mapping tools, including VOSviewer and Biblioshiny R studio. Through co-citation analysis, bibliographic coupling, co-occurrence of keywords analysis, thematic mapping, and thematic evolution analysis, the study uncovers the essential characteristics of the research field...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38356257/associations-between-income-and-survival-in-cholangiocarcinoma-a-comprehensive-subtype-based-analysis
#28
JOURNAL ARTICLE
Calvin X Geng, Anuragh R Gudur, Jagannath Kadiyala, Daniel S Strand, Vanessa M Shami, Andrew Y Wang, Alexander Podboy, Tri M Le, Matthew Reilley, Victor Zaydfudim, Ross C D Buerlein
BACKGROUNDS/AIMS: Socioeconomic determinants of health are incompletely characterized in cholangiocarcinoma (CCA). We assessed how socioeconomic status influences initial treatment decisions and survival outcomes in patients with CCA, additionally performing multiple sub-analyses based on anatomic location of the primary tumor. METHODS: Observational study using the 2018 submission of the Surveillance, Epidemiology, and End Results (SEER)-18 Database. In total, 5,476 patients from 2004-2015 with a CCA were separated based on median household income (MHI) into low income (< 25th percentile of MHI) and high income (> 25th percentile of MHI) groups...
February 15, 2024: Annals of Hepato-Biliary-Pancreatic Surgery
https://read.qxmd.com/read/38355501/examining-birth-preparedness-and-complication-readiness-a-systematic-review-and-meta-analysis-of-pregnant-and-recently-delivered-women-in-india
#29
JOURNAL ARTICLE
Tanya Singh, Brajaraj Tripathy, Anuj Kumar Pandey, Diksha Gautam, Sidharth Sekhar Mishra
BACKGROUND: Birth preparedness and complication readiness (BPCR) is an essential component of safe motherhood programs. This study aims to systematically identify and synthesize available evidence on birth preparedness and complication readiness among pregnant and recently delivered women in India. METHODS: The study followed PRISMA guidelines and used databases such as PubMed, Cochrane Library, and ProQuest. Joanna Briggs Institute [JBI] Tool was used for critical appraisal of studies...
February 14, 2024: BMC Women's Health
https://read.qxmd.com/read/38351473/exploring-the-variations-of-the-pancreatic-ductal-system-a-systematic-review-and-meta-analysis-of-observational-studies
#30
JOURNAL ARTICLE
Adil Asghar, Ravi Kant Narayan, Nagavalli Basavanna Pushpa, Apurba Patra, Kumar Satish Ravi, R Shane Tubbs
The exocrine part of the pancreas has a duct system called the pancreatic ductal system (PDS). Its mechanism of development is complex, and any reorganization during early embryogenesis can give rise to anatomical variants. The aim of this study is to collect, classify, and analyze published evidence on the importance of anatomical variants of the PDS, addressing gaps in our understanding of such variations. The MEDLINE, Web of Science, Embase, and Google Scholar databases were searched to identify publications relevant to this review...
February 14, 2024: Anatomy & Cell Biology
https://read.qxmd.com/read/38346412/postpartum-depression-and-inflammatory-biomarkers-of-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-monocyte-lymphocyte-ratio-a-prospective-observational-study
#31
JOURNAL ARTICLE
Marco La Verde, Mario Luciano, Mario Fordellone, Gaia Sampogna, Davide Lettieri, Marica Palma, Daniele Torella, Maria Maddalena Marrapodi, Matteo Di Vincenzo, Marco Torella
OBJECTIVES: Postpartum depression (PPD) is a severe mental health disorder affecting a significant proportion of mothers, often undiagnosed and untreated, with potential long-term effects. While numerous studies have identified risk factors for PPD, the relationship between inflammatory markers and PPD remains unknown. This study aims to investigate the potential correlation between indirect inflammatory markers, specifically neutrophil-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR), and the risk of developing PPD, assessed by the Edinburgh Postnatal Depression Scale (EPDS)...
February 12, 2024: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/38339789/the-influence-of-the-perceived-requirements-of-the-next-match-and-motivation-on-the-mental-fatigue-of-soccer-players
#32
JOURNAL ARTICLE
A Rubio-Morales, J Díaz-García, L D Harper, T García-Calvo
The high cognitive and/or emotional demands of competition can lead to a state of mental fatigue which has shown to be detrimental to soccer performance. However, there is a need to further understand the true mental demands of soccer players. The aim of the present study was to analyze the influence of motivation and the perceived requirements of the next match on mental fatigue perceived by soccer players over the passing of a season. The combined effect of both variables on the perception of mental fatigue, as well as the influence of the time of the season on perceived mental fatigue, were also analyzed...
February 2024: Scandinavian Journal of Medicine & Science in Sports
https://read.qxmd.com/read/38335186/prevalence-of-phenotypic-multi-drug-resistant-klebsiella-species-recovered-from-different-human-specimens-in-ethiopia-a-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Biniyam Kijineh, Tsegaye Alemeyhu, Mulugeta Mengistu, Musa Mohammed Ali
BACKGROUND: Multidrug-resistant (MDR) Klebsiella species are among public health important bacteria that cause infections difficult to treat with available antimicrobial agents. Infections with Klebsiella lead to high morbidity and mortality in developing countries particularly in patients admitted to the intensive care unit. This systematic review and meta-analysis aimed to determine the pooled prevalence of MDR Klebsiella species from different human specimens using studies conducted in Ethiopia from 2018-2022...
2024: PloS One
https://read.qxmd.com/read/38333271/prognostic-indicators-for-hospitalization-and-icu-admission-in-people-with-multiple-sclerosis-and-covid-19-an-analysis-of-the-covid-19-in-ms-global-data-sharing-initiative-dataset
#34
JOURNAL ARTICLE
Maria A Garcia-Dominguez, Vincent Kipkorir, Bahadar S Srichawla
OBJECTIVES: To analyze the symptoms and severity of coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (pwMS) on disease-modifying therapies using data from the COVID-19 in multiple sclerosis (MS) Global Data Sharing Initiative dataset. METHODS: The open-access COVID-19 in MS Global Data Sharing Initiative dataset was obtained through credentialed access using PhysioNet. The variables analyzed included BMI, symptoms of COVID-19, age, current use of disease-modifying therapy (DMT), efficacy of DMT, comorbidities, hospitalization status, and type of MS...
February 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38322752/prevalence-and-levels-of-disability-post-road-traffic-orthopaedic-injuries-in-rwanda
#35
JOURNAL ARTICLE
J C Allen Ingabire, Aimee Stewart, Jean Baptiste Sagahutu, Gerard Urimubenshi, Georges Bucyibaruta, Sonti Pilusa, Carine Uwakunda, Didace Mugisha, Leontine Ingabire, David Tumusiime
BACKGROUND: Prolonged disability resulting from road traffic injuries (RTIs) contributes significantly to morbidity and disease burden. A good understanding of the prevalence and the level of disability of orthopaedic injuries in developing countries is crucial for improvement; however, such data are currently lacking in Rwanda. OBJECTIVES: To determine the prevalence and levels of disability of 2 years post-road traffic orthopaedic injuries in Rwanda. METHOD: A multicentre, cross-sectional study from five Rwandan referral hospitals of 368 adult RTI victims' sustained from accidents in 2019...
2024: African Journal of Disability
https://read.qxmd.com/read/38322313/dynamic-monitoring-of-neutrophil-lymphocyte-ratio-apache-ii-score-and-sofa-score-predict-prognosis-and-drug-resistance-in-patients-with-acinetobacter-baumannii-calcoaceticus-complex-bloodstream-infection-a-single-center-retrospective-study
#36
JOURNAL ARTICLE
Zhiyong Wei, Lina Zhao, Jia Yan, Xuejie Wang, Qun Li, Yuanyuan Ji, Jie Liu, Yan Cui, Keliang Xie
OBJECTIVE: This study aimed to evaluate the clinical value of dynamic monitoring of neutrophil/lymphocyte ratio (NLR), APACHE II (Acute Physiology and Chronic Health Evaluation II) score, and Sequential Organ Failure Assessment (SOFA) score in predicting 28-day prognosis and drug resistance in patients with bloodstream infection with Acinetobacter baumannii-calcoaceticus complex (Abc complex). PATIENTS AND METHODS: In this research, individuals admitted to Tianjin Medical University General Hospital from January 2017 to March 2023 with bloodstream infections and a minimum of one Abc complex positive blood culture were chosen...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38307162/effectiveness-of-non-pharmacological-interventions-for-adolescents-with-type-1-diabetes-in-the-last-five-years-a-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
DaeEun Lee, Haejung Lee, YoonYoung Shin, Gaeun Park
PURPOSE: Evidence on non-pharmacological interventions for adolescents with type 1 diabetes is unclear. This review aimed to evaluate the effectiveness of non-pharmacological intervention in adolescents with type 1 diabetes. METHODS: We conducted a search on databases from November 11 to 19, 2022, for randomized controlled trials for the effects of non-pharmacological intervention in adolescents with type 1 diabetes. To identify recent research trends, we included studies published from 2017 to November 2022...
February 2024: Asian Nursing Research
https://read.qxmd.com/read/38305160/enhanced-electrochemical-hydrogenation-of-benzaldehyde-to-benzyl-alcohol-on-pd-ni-mof-by-modifying-the-adsorption-configuration
#38
JOURNAL ARTICLE
Li Gong, Chao Yue Zhang, Junshan Li, Guillem Montaña-Mora, Marc Botifoll, Tiezhu Guo, Jordi Arbiol, Jin Yuan Zhou, Tanja Kallio, Paulina R Martínez-Alanis, Andreu Cabot
Electrocatalytic hydrogenation (ECH) approaches under ambient temperature and pressure offer significant potential advantages over thermal hydrogenation processes but require highly active and efficient hydrogenation electrocatalysts. The performance of such hydrogenation electrocatalysts strongly depends not only on the active phase but also on the architecture and surface chemistry of the support material. Herein, Pd nanoparticles supported on a nickel metal-organic framework (MOF), Ni-MOF-74, are prepared, and their activity toward the ECH of benzaldehyde (BZH) in a 3 M acetate (pH 5...
February 2, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38280634/reliability-and-variability-of-ki-67-digital-image-analysis-methods-for-clinical-diagnostics-in-breast-cancer
#39
JOURNAL ARTICLE
Melanie Dawe, Wei Shi, Tian Yu Liu, Katherine Lajkosz, Yukiko Shibahara, Nakita E K Gopal, Rokshana Geread, Seyed Mirjahanmardi, Carrie X Wei, Sehrish Butt, Moustafa Abdalla, Sabrina Manolescu, Sheng-Ben Liang, Dianne Chadwick, Michael H A Roehrl, Trevor D McKee, Adewunmi Adeoye, David McCready, April Khademi, Fei-Fei Liu, Anthony Fyles, Susan J Done
Ki-67 is a nuclear protein associated with proliferation, and a strong potential biomarker in breast cancer, but is not routinely measured in current clinical management due to a lack of standardization. Digital image analysis (DIA) is a promising technology that could allow high throughput analysis and standardization. There is a dearth of data on the clinical reliability as well as intra- and inter-algorithmic variability of different DIA methods. In this study, we scored and compared a set of breast cancer cases in which manually counted Ki-67 has already been demonstrated to have prognostic value (n=278) to five DIA methods; namely, Aperio ePathology, Definiens Tissue Studio, Qupath, an unsupervised IHC color histogram (IHCCH) algorithm and a deep learning pipeline piNET...
January 25, 2024: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://read.qxmd.com/read/38275354/relationship-between-athletes-big-five-model-of-personality-and-athletic-performance-meta-analysis
#40
REVIEW
Ji-Hye Yang, Hye Jin Yang, Chulhwan Choi, Chul-Ho Bum
Academic interest in athletic performance is ongoing. To examine the correlation between athletic performance and athletes' personality types, data extraction in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was completed in October 2021, and a meta-analysis was performed using 180 data from 18 selected papers using the "meta" package version 4.8-4 of R Studio 3.3.3. As a result, these selected studies proved to have reliable quality in proceeding with this study via quality assessment...
January 19, 2024: Behavioral Sciences
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