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https://www.readbyqxmd.com/read/30290915/-obesity-high-blood-pressure-and-physical-activity-levels-in-a-black-african-population
#1
K S Malik, K A Adoubi
PURPOSE OF THE STUDY: To determine the prevalence of general and abdominal obesity and to describe their association with high blood pressure and physical activity levels in a peri-urban population in West Africa. METHODS: A cross-sectional study was conducted in Abidjan (Cote d'Ivoire) in the Anonkoi 3 district, from 24 April to 23 May 2014. Obesity, abdominal obesity and physical activity levels were assessed. Blood pressure was measured. The data were entered on the Epi data software (version 3...
October 2, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/30110445/synthesis-and-molecular-docking-studies-of-some-novel-schiff-bases-incorporating-6-butylquinolinedione-moiety-as-potential-topoisomerase-ii%C3%AE-inhibitors
#2
Hany M Hassanin, Rabah A T Serya, Wafaa R Abd Elmoneam, Mai A Mostafa
A series of novel pyranoquinolinone-based Schiff's bases were designed and synthesized. They were evaluated for topoisomerase IIβ (TOP2B) inhibitory activity, and cytotoxicity against breast cancer cell line (MCF-7) for the development of novel anticancer agents. A molecular docking study was employed to investigate their binding and functional properties as TOP2B inhibitors, using the Discovery Studio 2.5 software, where they showed very interesting ability to intercalate the DNA-topoisomerase complex. Compounds 2a , 2c and 2f showed high docking score values (82...
June 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/30102877/do-implant-surgical-guides-allow-an-adequate-zone-of-keratinized-tissue-for-flapless-surgery
#3
Janina Golob Deeb, Sompop Bencharit, Christopher A Loschiavo, Matthew Yeung, Daniel Laskin, George R Deeb
PURPOSE: A major advantage of guided implant surgery using 3-dimensionally printed guides is the ability to perform accurate flapless surgery. A drawback of a flapless technique is the inability to manipulate soft tissue to ensure sufficient gingiva around the implant. The purpose of this study was to determine how often flapless surgery using surgical guides results in less than 2 mm of keratinized tissue surrounding the implant. MATERIALS AND METHODS: This retrospective analysis included 27 maxillary and 27 mandibular implant sites that underwent treatment planning for implant-guided surgery using 3Shape Implant Studio (3Shape, Copenhagen, Denmark)...
July 19, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29992081/metabolic-health-and-academic-achievement-in-youth-at-risk-for-high-school-dropout-in-rural-mississippi-the-role-of-classroom-management
#4
Megan E Holmes, Mallory A Kvasnicka, D Kay Brocato, Heather E Webb
Disparities in health and academic achievement affect large cross-sections of the same population subgroups. This study examined the relationship metabolic health and academic achievement in youth "at risk" for school dropout in rural Mississippi. Fifteen adolescents participated in a studio based learning educational summer camp and subsequent follow-up sessions during the regular school year that were aimed at developing knowledge of core curriculum subjects by developing design projects based on the camp STEM-related theme...
September 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29972947/-effect-of-three-types-of-rapid-maxillary-expansion-a-three-dimensional-finite-element-study
#5
M H Wang, Z L Ge, L Tian, P R Li, Y Q Che
Objective: To evaluate the transverse displacement, stress distribution and tendency of change in tooth, alveolar bone and mid-palatal suture using three kinds of rapid maxillary expansion methods. Methods: Cone-beam CT image data was obtained by scanning skulls of a volunteer. Three-dimensional models of maxillary complex were re-established using Mimics and Geomagic Studio and models of Hyrax expander, Haas expander and miniscrew-assisted rapid palatal expander (MARPE) were established using ANSYS Workbench...
November 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/29922868/is-14-the-new-40-trends-in-gallstone-disease-and-cholecystectomy-in-australian-children
#6
Douglas Greer, Sean Heywood, David Croaker, Siva Gananadha
BACKGROUNDS: Gallstone disease and cholecystectomy have been uncommon in paediatric patients and associated with haemolytic disease and prematurity. Many countries have observed an increase in the prevalence of paediatric gallstones and cholecystectomy with increasing childhood obesity. The purpose of this study was to determine any trend in prevalence in Australian children and the role of obesity. METHODS: Chart review was conducted for patients undergoing cholecystectomy under 18 in 25 years between 1992 and 2016...
June 19, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29785625/exploring-the-association-between-electronic-health-record-use-and-burnout-among-psychiatry-residents-and-faculty-a-pilot-survey-study
#7
Nicholas M Domaney, John Torous, William E Greenberg
OBJECTIVE: Burnout is a phenomenon with profound negative effects on the US healthcare system. Little is known about the relationship between time spent working on electronic health record (EHR) and burnout among psychiatry residents. The purpose of this study is to generate preliminary data on EHR use and burnout among psychiatry residents and faculty. METHODS: In August 2017, psychiatry residents and faculty at an academic medical center were given the Maslach Burnout Inventory (MBI), a standardized measurement tool for burnout, and a survey of factors related to EHR use and potential risk factors for burnout...
May 21, 2018: Academic Psychiatry
https://www.readbyqxmd.com/read/29775402/a-note-on-poisson-goodness-of-fit-tests-for-ionizing-radiation-induced-chromosomal-aberration-samples
#8
Manuel Higueras, J E González, Marina Di Giorgio, J F Barquinero
PURPOSE: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations in blood cells comes from an homogeneous or inhomogeneous exposure. MATERIALS AND METHODS: Three Poisson exact goodness-of-fit test from the literature are introduced and implemented in the R environment. A Shiny R Studio application, named GOF Poisson, has been updated for the purpose of giving support to this work...
July 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29763727/antibacterial-activity-of-flavonoid-isolated-from-trianthema-decandra-against-pseudomonas-aeruginosa-and-molecular-docking-study-of-fabz
#9
Rajarathinam Geethalakshmi, Jagadish Chandrabose Sundaramurthi, Dronamraju V L Sarada
The natural product flavonoid demonstrates an extensive sort of pharmacological properties including antimicrobial activity. Although its Pseudomonas aeruginosa inhibition has been discovered, no target for action against flavonoid has been revealed to date. The anti - P. aeruginosa activity of the 2 - (3', 4' dihydroxy-phenyl) - 3, 5, 7-trihydroxy-chromen-4-one isolated from T. decandra was evaluated by disc diffusion and minimum inhibitory concentration methods. The molecular docking of the flavonoid isolated from T...
August 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29732977/rational-discovery-of-novel-squalene-synthase-inhibitors-through-pharmacophore-modelling
#10
Avani B Chokshi, Mahesh T Chhabria, Pritesh R Desai
INTRODUCTION: In the present research work, a pharmacophore based virtual screening was performed using Discovery Studio 2.1 for the discovery of some novel molecules as inhibitors of Squalene Synthase Enzyme, a key enzyme in cholesterol biosynthetic pathway. METHODS: A quantitative pharmacophore HypoGen was generated and the best HypoGen had two ring aromatic and one hydrogen bond acceptor lipid features. The best HypoGen showed a very good correlation coefficient (r = 0...
2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29602340/influence-of-nasoalveolar-molding-on-skeletal-development-in-patients-with-unilateral-cleft-lip-and-palate-at-5-years-of-age
#11
Bengisu Akarsu-Guven, Arda Arisan, Figen Ozgur, Muge Aksu
INTRODUCTION: The aim of this retrospective study was to assess the influence of presurgical nasoalveolar molding (NAM) on skeletal development in patients with operated unilateral cleft lip and palate at 5 years of age. MATERIALS: Lateral cephalometric radiographs of 26 unilateral cleft lip and palate patients who had undergone presurgical NAM (NAM group) and 20 unilateral cleft lip and palate patients who did not have any presurgical NAM (non-NAM group) were analyzed...
April 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29578464/biological-and-nano-indentation-properties-of-polybenzoxazine-based-composites-reinforced-with-zirconia-particles-as-a-novel-biomaterial
#12
L Lotfi, J Javadpour, M R Naimi-Jamal
INTRODUCTION: The biological and mechanical properties of substances are relevant to their application as biomaterials and there are many efforts to enhance biocompatibility and mechanical properties of bio-medical materials. OBJECTIVES: In this study, to achieve a low rate of shrinkage during polymerization, good mechanical properties, and excellent biocompatibility, benzoxazine based composites were synthesized. METHODS: Benzoxazine monomer was synthesized using a solventless method...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29561777/an-internet-of-things-system-for-underground-mine-air-quality-pollutant-prediction-based-on-azure-machine-learning
#13
ByungWan Jo, Rana Muhammad Asad Khan
The implementation of wireless sensor networks (WSNs) for monitoring the complex, dynamic, and harsh environment of underground coal mines (UCMs) is sought around the world to enhance safety. However, previously developed smart systems are limited to monitoring or, in a few cases, can report events. Therefore, this study introduces a reliable, efficient, and cost-effective internet of things (IoT) system for air quality monitoring with newly added features of assessment and pollutant prediction. This system is comprised of sensor modules, communication protocols, and a base station, running Azure Machine Learning (AML) Studio over it...
March 21, 2018: Sensors
https://www.readbyqxmd.com/read/29549613/climate-variability-and-dengue-hemorrhagic-fever-in-southeast-sulawesi-province-indonesia
#14
Ramadhan Tosepu, Kraichat Tantrakarnapa, Kanchana Nakhapakorn, Suwalee Worakhunpiset
To determine the association of climatic factors and dengue hemorrhagic fever and to develop the prediction approach of future dengue transmission. The study used totally monthly dengue hemorrhagic fever cases at Health Office Kendari, Southeast Sulawesi, Indonesia. Monthly meteorological data, consisting of temperature, rainfall, and humidity, was obtained from the Meteorology, Climatology and Geophysics Agency in Kendari district. All data analysis, including Spearman and Poisson distribution, was carried out in R Studio (version 3...
May 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29548966/significant-injury-of-the-mammillothalamic-tract-without-injury-of-the-corticospinal-tract-after-aneurysmal-subarachnoid-hemorrhage-a-retrospective-diffusion-tensor-imaging-study
#15
Rami Darwazeh, Miao Wei, Jianjun Zhong, Zhaosi Zhang, Fajin Lv, Mazhar Darwazeh, Yi Guo, Yi Yan, Samer S Hoz, Xiaochuan Sun
OBJECTIVE: Little is known about the pathophysiologic mechanisms of white matter injury after aneurysmal subarachnoid hemorrhage (aSAH). The purpose of this study is to investigate whether the mammillothalamic tract (MTT) or corticospinal tract (CST) is more affected by aSAH in the same patients with good outcome (Grade 5 on Glasgow Outcome Scale at 3 months) using diffusion tensor imaging (DTI). METHODS: Between June 2013 and September 2016, 21 patients with aSAH with good outcome and 21 sex- and age-matched normal healthy control participants were recruited...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29493654/preliminary-findings-on-the-association-between-attachment-patterns-and-levels-of-growth-hormone-in-a-sample-of-children-with-non-organic-failure-to-thrive
#16
Marta Fojanesi, Mariana Gallo, Matteo Spaziani, Federica Russo, Martina Valentini, Francesco Saverio Bersani, Massimo Biondi, Antonio Radicioni
Introduction: Deficiency of growth hormone (GH) in absence of pituitary injuries is one of the causes of short stature and of the non organic failure to thrive (NOFTT) condition. Advances in developmental psychology have highlighted the role of emotions and caregiving behaviors in the organization of child’s personality and psychobiology, with the mother-son attachment bond being considered a fundamental developmental experience. The objective of the present preliminary study was to assess whether there are significant correlations between attachment patterns and GH levels in a sample of subjects with NOFTT...
January 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29493425/pharmacophore-and-structure-based-drug-design-molecular-dynamics-and-admet-tox-studies-to-design-novel-potential-pad4-inhibitors
#17
Mariana P Barcellos, Cleydson B R Santos, Leonardo B Federico, Paulo Fernando de Almeida, Carlos H T de Paula da Silva, Carlton A Taft
We have used docking (GLIDE), pharmacophore modeling (Discovery Studio), long trajectory molecular dynamics (Discovery Studio) and ADMET/Tox (QikProp and DEREK) to investigate PAD4 in order to determine potential novel inhibitors and hits. We have carried out virtual screening in the ZINC natural compounds database. Pharmacokinetics and Toxicity of the best hits were assessed using databases implemented in softwares that create models based on chemical structures taking into account consideration about the toxicophoric groups...
March 12, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29454290/ligand-based-computer-aided-drug-design-reveals-new-tropomycin-receptor-kinase-a-trka-inhibitors
#18
Rand Shahin, Iman Mansi, Lubna Swellmeen, Tahani Alwidyan, Nabil Al-Hashimi, Yaser Al-Qarar'h, Omar Shaheen
Targeting tropomycin kinase A (TrkA) by small molecule inhibitors is considered as a promising strategy for treating several human cancers. To achieve this goal, a ligand based QSAR model was applied using the Discovery studio 4.5 (DS 4.5). Hence, a total list of 161 TrkA inhibitors was investigated. The TrkA inhibitors were extensively explored to detect their optimal physicochemical properties and pharmacophoric binding modes, which were converted into numeric descriptors and allowed to compete within the context of the Genetic Function Algorithm (GFA) approximations to find the subset of terms that correlates best with the activity...
March 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29449818/is-reading-instruction-evidence-based-analyzing-teaching-practices-using-t-patterns
#19
Natalia Suárez, Carmen R Sánchez, Juan E Jiménez, M Teresa Anguera
The main goal of this study was to analyze whether primary teachers use evidence-based reading instruction for primary-grade readers. The study sample consisted of six teachers whose teaching was recorded. The observation instrument used was developed ad hoc for this study. The recording instrument used was Match Vision Studio. The data analysis was performed using SAS, GT version 2.0 E, and THEME. The results indicated that the teaching practices used most frequently and for the longest duration were: feedback (i...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29355376/do-multiple-body-modifications-alter-pain-threshold
#20
A Yamamotová, P Hrabák, P Hříbek, R Rokyta
In recent years, epidemiological data has shown an increasing number of young people who deliberately self-injure. There have also been parallel increases in the number of people with tattoos and those who voluntarily undergo painful procedures associated with piercing, scarification, and tattooing. People with self-injury behaviors often say that they do not feel the pain. However, there is no information regarding pain perception in those that visit tattoo parlors and piercing studios compared to those who don't...
December 30, 2017: Physiological Research
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