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https://www.readbyqxmd.com/read/30059280/kdm2a-b-lysine-demethylases-and-their-alternative-isoforms-in-development-and-disease
#1
Tomáš Vacík, Dijana Lađinović, Ivan Raška
Aberrant levels of histone modifications lead to chromatin malfunctioning and consequently to various developmental defects and human diseases. Therefore, the proteins bearing the ability to modify histones have been extensively studied and the molecular mechanisms of their action are now fairly well understood. However, little attention has been paid to naturally occurring alternative isoforms of chromatin modifying proteins and to their biological roles. In this review, we focus on mammalian KDM2A and KDM2B, the only two lysine demethylases whose genes have been described to produce also an alternative isoform lacking the N-terminal demethylase domain...
July 30, 2018: Nucleus
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#2
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep® LBC workload. HPV testing was performed in each case using residual LBC material...
February 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29090843/changes-in-oxygen-saturation-and-the-retinal-nerve-fibre-layer-in-patients-with-optic-neuritis-a-pilot-study
#3
Tereza Svrčinová, Jan Mareš, Oldřich Chrapek, Irena Šínová, Martina Rybariková, Pavel Otruba, Petr Kaňovský, Martin Šín
PURPOSE: Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). METHODS: Thirty-two patients with ON due to MS within 3 months of onset of symptoms were enrolled [22 females, 10 males, age 34 ± 9 years, median 32.5 years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]...
May 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29072553/prospective-memory-impairment-in-idiopathic-rem-sleep-behavior-disorder
#4
Ondrej Bezdicek, Tomáš Nikolai, Jiří Nepožitek, Pavla Peřinová, David Kemlink, Pavel Dušek, Iva Příhodová, Simona Dostálová, Veronika Ibarburu, Jiří Trnka, Karel Kupka, Zuzana Mecková, Jiří Keller, Josef Vymazal, Evžen Růžička, Karel Šonka, Petr Dušek
OBJECTIVE: The aim of the present study was to investigate if prospective memory (PM) is impaired in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stage of neurodegeneration with pathological storage of alpha-synuclein. METHOD: Sixty iRBD patients with polysomnography-confirmed RBD without parkinsonism and dementia and 30 demographically matched normal controls (NC) were enrolled in the present study...
July 2018: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28649816/evaluation-of-the-influence-of-lubricants-on-the-viscoelastic-properties-of-tablets-using-the-stress-relaxation-test
#5
Petra Svačinová, Pavel Ondrejček, Jan Stoniš, Johana Jirásková, Miloslava Rabišková, Zdenka Šklubalová
No abstract text is available yet for this article.
November 2015: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28649815/evaluation-of-water-absorption-rate-of-tablets-by-using-an-enslin-neff-device
#6
Jan Stoniš, Zdenka Šklubalová, Hana Hurychová, Pavel Ondrejček, Petra Svačinová
No abstract text is available yet for this article.
November 2015: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28649813/evaluation-of-compressibility-of-tableting-mixtures-using-the-compaction-equation
#7
Pavel Ondrejček, Petra Svačinová, Jan Stoniš, Zdenka Šklubalová, Miloslava Rabišková
No abstract text is available yet for this article.
November 2015: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/28619424/cerebrospinal-fluid-and-serum-levels-of-interleukin-8-in-patients-with-multiple-sclerosis-and-its-correlation-with-q-albumin
#8
Z Matejčíková, J Mareš, V Sládková, T Svrčinová, J Vysloužilová, J Zapletalová, P Kaňovský
INTRODUCTION: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system (CNS). Autoimmune inflammation is common in the early stages of MS and is followed by neurodegenerative processes. The result of these changes is axon and myelin breakdown. The paraclinical examination methods are an important part of the diagnostic process. Magnetic resonance imaging of the brain and the cervical spinal cord and an examination of cerebrospinal fluid (CSF) are common paraclinical examinations...
May 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28569194/severe-child-form-of-primary-hyperoxaluria-type-2-a-case-report-revealing-consequence-of-grhpr-deficiency-on-metabolism
#9
Jana Konkoľová, Ján Chandoga, Juraj Kováčik, Marcel Repiský, Veronika Kramarová, Ivana Paučinová, Daniel Böhmer
BACKGROUND: Primary hyperoxaluria type 2 is a rare monogenic disorder inherited in an autosomal recessive pattern. It results from the absence of the enzyme glyoxylate reductase/hydroxypyruvate reductase (GRHPR). As a consequence of deficient enzyme activity, excessive amounts of oxalate and L-glycerate are excreted in the urine, and are a source for the formation of calcium oxalate stones that result in recurrent nephrolithiasis and less frequently nephrocalcinosis. CASE PRESENTATION: We report a case of a 10-month-old patient diagnosed with urolithiasis...
May 31, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28266017/what-can-morphology-tell-us-about-ecology-of-four-invasive-goby-species
#10
COMPARATIVE STUDY
K Jakubčinová, P Simonović, B Števove, J Čanak Atlagić, V Kováč
This study presents a detailed comparative analysis of external morphology of four of the most invasive goby species in Europe (round goby Neogobius melanostomus, bighead goby Ponticola kessleri, monkey goby Neogobius fluviatilis and racer goby Ponticola gymnotrachelus) and interprets some ecological requirements of these species based on their morphological attributes. The results are evaluated within an ontogenetic context, and the morphological differences between the species are discussed in terms of the question: can special external shape adaptations help to assess the invasive potential of each species? The morphometric analyses demonstrate important differences between the four invasive gobies...
May 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28161895/comparative-study-of-dental-enamel-loss-after-debonding-braces-by-analytical-scanning-electron-microscopy-sem
#11
Jacqueline Adelina Rodríguez-Chávez, Jesús Arenas-Alatorre, Irma Araceli Belio-Reyes
Clinical procedures when shear forces are applied to brackets suggest adhesion forces between 2.8 and 10.0 MPa as appropriate. In this study dental enamel was evaluated by scanning electron microscopy (SEM) before and after removing the brackets. Thirty bicuspids (previous prophylaxis) with metallic brackets (Roth Inovation 0.022 GAC), Transbond Plus SEP 3M Unitek adhesive and Transbond XT 3M resin were used. The samples were preserved to 37°C during 24 hr and submited to tangential forces with the Instron Universal machine 1...
July 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28123121/-innovation-of-bisphosphonates-for-improvement-of-adherence
#12
REVIEW
Yasuhiro Takeuchi
Bisphosphonates are standard medicine for treatment of osteoporosis, and have been inovated to overcome complicated rules for their appropriate administration or their poor intestinal absorption. Not only weekly but also monthly oral bisphosphonates have been available. Furthermore, we are now allowed to choose intravenous administration of bisphosphonates for osteorporosis. Good persistance and adherence is another critical and essential issue to be solved to achive the aim of osteoprosis treatment with bisphosphonates...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/27932548/total-control-of-chromium-in-tanneries-thermal-decomposition-of-filtration-cake-from-enzymatic-hydrolysis-of-chrome-shavings
#13
P Kocurek, K Kolomazník, M Bařinová, J Hendrych
This paper deals with the problem of chromium recovery from chrome-tanned waste and thus with reducing the environmental impact of the leather industry. Chrome-tanned waste was transformed by alkaline enzymatic hydrolysis promoted by magnesium oxide into practically chromium-free, commercially applicable collagen hydrolysate and filtration cake containing a high portion of chromium. The crude and magnesium-deprived chromium cakes were subjected to a process of thermal decomposition at 650°C under oxygen-free conditions to reduce the amount of this waste and to study the effect of magnesium removal on the resulting products...
April 2017: Waste Management & Research
https://www.readbyqxmd.com/read/27058909/vagus-nerve-stimulation-for-the-treatment-of-heart-failure-the-inovate-hf-trial
#14
RANDOMIZED CONTROLLED TRIAL
Michael R Gold, Dirk J Van Veldhuisen, Paul J Hauptman, Martin Borggrefe, Spencer H Kubo, Randy A Lieberman, Goran Milasinovic, Brett J Berman, Sanja Djordjevic, Suresh Neelagaru, Peter J Schwartz, Randall C Starling, Douglas L Mann
BACKGROUND: Heart failure (HF) is increasing in prevalence and is a major cause of morbidity and mortality despite advances in medical and device therapy. Autonomic imbalance, with excess sympathetic activation and decreased vagal tone, is an integral component of the pathophysiology of HF. OBJECTIVES: The INOVATE-HF (Increase of Vagal Tone in Heart Failure) trial assessed the safety and efficacy of vagal nerve stimulation (VNS) among patients with HF and a reduced ejection fraction...
July 12, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27026289/can-4-port-laparoscopic-cholecystectomy-remain-the-gold-standard-for-gallbladder-surgery
#15
Kinyas Kartal, Mehmet Uludag
UNLABELLED: Since the first laparoscopic cholecystectomy (LC), laparoscopic approach has been the focus of surgical authorities and continued its technical revolution. With increasing surgical experience, a trend toward even more minimally invasive approaches has led to laparoscopic surgery to new inovations. Current surgical procedures are: four ports (4PLC), still the gold standart technique, three ports (3PLC), two ports (2PLC) and single port laparoscopic cholecystectomy (SPLC). Robotic cholecystectomy (RC) and natural orifice translumenal endoscopic surgery (NOTES) are the other new techniques for performing cholecystectomy...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/25558711/-organization-and-technology-in-the-grocery-store-sector
#16
REVIEW
Edy Gambetti
In Italy, grocery stores develop an annual turnover of 92 billion of , (data referred to 2013) and have 28.232 stores spread over a commercial area of 17.224.000 m2. The business involved are 252, linked with 30 important distribution leader companies. The total workforce is about 280.000 people. The grocery stores structure is composed by suppliers and producers warehouses and different kinds of stores (hypermarkets, supermarkets, shops and discounts). In the stores, the technological progress concerns fundamentally back-office operations; the improvement of information and computer science is the main renewal source...
October 2014: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/25480151/uronyl-2-o-sulfotransferase-potentiates-fgf2-induced-cell-migration
#17
Katerina Nikolovska, Dorothe Spillmann, Daniela G Seidler
Fibroblast growth factor 2 (Fgf2) is involved in several biological functions. Fgf2 requires glycosaminoglycans, like chondroitin and dermatan sulfates (hereafter denoted CS/DS) as co-receptors. CS/DS are linear polysaccharides composed of repeating disaccharide units [-4GlcUAb1-3-GalNAc-b1-] and [-4IdoUAa1-3-GalNAc-b1-],which can be sulfated. Uronyl 2-O-sulfotransferase (Ust)introduces sulfation at the C2 of IdoUA and GlcUA resulting inover-sulfated units. Here, we investigated the role of Ust-mediated CS/DS 2-O sulfation in Fgf2-induced cell migration...
February 1, 2015: Journal of Cell Science
https://www.readbyqxmd.com/read/24475333/evaluation-of-a-liquid-phase-colorimetric-method-for-rapid-antibacterial-susceptibility-testing
#18
Siavosh Salmanzadeh-Ahrabi, Tanıl Kocagöz
BACKGROUND AND OBJECTIVE: Early determination of antibacterial susceptibility increases the success of therapy, decreases unnecessary use of antibacterial agents and side-effects, and lowers the overall healthcare cost. MATERIALS AND METHODS: A rapid colorimetric method for antibacterial susceptibility testing named Qui-Sensitest (Inovative Biotechnology Organization, Istanbul, Turkey) was evaluated in this study. RESULTS: Qui-Sensitest proved to be a reliable rapid test for determining antibacterial susceptibility having an overall agreement of 97...
September 2013: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/23946944/guest-editors-introduction-special-section-on-learning-deep-architectures
#19
Samy Bengio, Li Deng, Hugo Larochelle, Honglak Lee, Ruslan inov Salakhutdinov
No abstract text is available yet for this article.
August 2013: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/23585574/pilot-study-of-a-protocol-to-administer-inhaled-nitric-oxide-to-treat-severe-acute-submassive-pulmonary-embolism
#20
Jeffrey A Kline, Jackeline Hernandez, John S Garrett, Alan E Jones
OBJECTIVE: Inhaled nitric oxide has been reported to benefit patients with acute pulmonary embolism (PE). To date, all published literature has derived from case reports or case series conducted without a structured protocol. Here we report the results of a phase I trial with a predefined clinical protocol to treat patients with CT-demonstrated, submassive PE and moderate to severe dyspnoea. METHODS: Patients were recruited from the emergency department of an academic teaching hospital...
June 2014: Emergency Medicine Journal: EMJ
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