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https://www.readbyqxmd.com/read/29036382/musitedeep-a-deep-learning-framework-for-general-and-kinase-specific-phosphorylation-site-prediction
#1
Duolin Wang, Shuai Zeng, Chunhui Xu, Wangren Qiu, Yanchun Liang, Trupti Joshi, Dong Xu
Motivation: Computational methods for phosphorylation site prediction play important roles in protein function studies and experimental design. Most existing methods are based on feature extraction, which may result in incomplete or biased features. Deep learning as the cutting-edge machine learning method has the ability to automatically discover complex representations of phosphorylation patterns from the raw sequences, and hence it provides a powerful tool for improvement of phosphorylation site prediction...
August 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29031567/operation-breakthrough-in-2017-builds-on-the-past
#2
Mary Esselman, Brijin Gardner, Marsha Gillespie
Operation Breakthrough (OB) is one of Missouri's largest early Head Start program and provides a variety of other services related to early childhood education and family support to low-income families who live in the poorest neighborhoods of Kansas City. Currently 96% of its preschool children enter kindergarten ready to learn. Current CLASS(TM) scores for Emotional Support, Organizational Support, and Instructional Support exceed national averages. In this paper, we describe the range of services it provides and give details of its organizational structure and budget...
September 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29023157/public-health-and-school-nurses-perceptions-of-barriers-to-hpv-vaccination-in-missouri
#3
Darson Rhodes, Joseph Visker, Carol Cox, Emily Forsyth, Kendra Woolman
Human Papilloma Virus (HPV) is associated with various forms of cancer and is preventable with vaccination. Nurses are in a unique position to directly influence a person's decision to receive the HPV vaccine. A statewide sample of both school and public health nurses was used to assess knowledge and attitudes related to the HPV vaccine as well as nurse's behaviors and behavioral intentions toward educating parents and recommending the vaccine. Positive attitudes and adequate knowledge levels were found, however, the majority of school nurses did not provide information and resources to parents...
October 2017: Journal of Community Health Nursing
https://www.readbyqxmd.com/read/28993601/potency-of-an-inactivated-influenza-vaccine-prepared-from-a-duck-hokkaido-162-2013-h2n1-against-a-challenge-with-a-swine-missouri-2124514-2006-h2n3-in-mice
#4
Mizuho Suzuki, Masatoshi Okamatsu, Takahiro Hiono, Keita Matsuno, Yoshihiro Sakoda
H2N2 influenza virus caused a pandemic starting in 1957 but has not been detected in humans since 1968. Thus, most people are immunologically naive to viruses of the H2 subtype. In contrast, H2 influenza viruses are continually isolated from wild birds, and H2N3 viruses were isolated from pigs in 2006. H2 influenza viruses could cause a pandemic if re-introduced into humans. In the present study, a vaccine against H2 influenza was prepared as an effective control measure against a future human pandemic. A/duck/Hokkaido/162/2013 (H2N1), which showed broad antigenic cross-reactivity, was selected from the candidate H2 influenza viruses recently isolated from wild birds in Asian countries...
October 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28993075/call-to-action-aprns-in-u-s-nursing-homes-to-improve-care-and-reduce-costs
#5
Marilyn J Rantz, Nancy M Birtley, Marcia Flesner, Charles Crecelius, Cathy Murray
BACKGROUND: Centers for Medicare and Medicaid Innovation Center sponsored the initiative to reduce avoidable hospitalizations among nursing facility residents. PURPOSE: Missouri Quality Initiative (MOQI) designed inter-professional model in nursing homes with advanced practice registered nurses (APRNs). METHOD: MOQI APRN model was implemented for 4 years in 16 nursing homes in a metro area of the Midwest. Hospitalizations were reduced (40% all-cause, 58% potentially avoidable), emergency room visits (54% all-cause, 65% potentially avoidable), Medicare expenditures for hospitalizations (34% all-cause, 45% potentially avoidable), and Medicare expenditures for emergency room visits (50% all-cause, 60% potentially avoidable) for long-stay nursing home residents...
September 21, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28991842/medical-school-factors-that-prepare-students-to-become-leaders-in-medicine
#6
Louise Arnold, Paul G Cuddy, Susan B Hathaway, Jennifer L Quaintance, Steven L Kanter
PURPOSE: To identify medical school factors graduates in major leadership positions perceive as contributing to their leadership development. METHOD: Using a phenomenological, qualitative approach, in August-November 2015 the authors conducted semistructured interviews with 48 medical leaders who were 1976-1999 baccalaureate-MD graduates of the University of Missouri-Kansas City School of Medicine (UMKC). At UMKC, they participated in longitudinal learning communities, the centerpiece for learning professional values and behaviors plus clinical skills, knowledge, and judgment, but received no formal leadership instruction...
October 3, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28991068/regulation-of-electroconvulsive-therapy-a-systematic-review-of-us-state-laws
#7
Robin Livingston, Chester Wu, Kathy Mu, M Justin Coffey
OBJECTIVES: The goal of this study was to systematically review current US state laws on electroconvulsive therapy (ECT) in order to provide a comprehensive resource to educate practitioners, potential patients, and lawmakers. METHODS: Individual state legislative Web sites were searched by 2 independent authors using the following search terms: "electroconvulsive therapy," "convulsive therapy," "electroconvulsant therapy," "electroshock therapy," and "shock therapy" from March 2017 to May 2017...
October 3, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28988836/parental-perceptions-risks-and-incidence-of-pediatric-unintentional-injuries
#8
Catherine M Hogan, Nancy L Weaver, Claire Cioni, Jessica Fry, Alyssa Hamilton, Samantha Thompson
INTRODUCTION: More than 9,000 children die annually from various causes of unintentional injury. Of all the pediatric unintentional injuries occurring in the United States, 8.7 million are treated in emergency departments, and 225,000 require hospitalization annually. Health education programs are available to address these injuries. The objective of this research was to examine the distribution of self-reported high priority injury risks in an urban Midwestern pediatric level 1 trauma center and investigate the relationship between parental perceptions and injury-prevention behaviors...
October 6, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28981311/investigating-the-relationship-between-posttraumatic-stress-symptoms-and-posttraumatic-growth-following-community-violence-the-role-of-anger
#9
David R Strasshofer, Zoë D Peterson, Marin C Beagley, Tara E Galovski
OBJECTIVE: Past research has revealed that posttraumatic stress disorder (PTSD) is characterized by disturbances in emotional reactivity, including anger reactions. In turn, posttraumatic stress symptoms (PTSS) and anger reactions have been shown to be independently associated with posttraumatic growth (PTG). As such, anger reactions may serve as a pathway of influence through which PTSS lead to PTG in trauma-exposed adults. METHOD: The current study examined cross-sectional relationships among PTSS, anger reactions, and PTG in 318 participants who were exposed to the violent political protests in Ferguson, Missouri after the officer-involved shooting of Michael Brown...
October 5, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28951905/chemistry-and-radiochemistry-of-as-re-and-rh-isotopes-relevant-to-radiopharmaceutical-applications-high-specific-activity-radionuclides-for-imaging-and-treatment
#10
Yutian Feng, Tim E Phelps, Valerie Carroll, Fabio Gallazzi, Gary Sieckman, Timothy J Hoffman, Charles L Barnes, Alan R Ketring, Heather M Hennkens, Silvia S Jurisson
The chemistry and radiochemistry of high specific activity radioisotopes of arsenic, rhenium and rhodium are reviewed with emphasis on University of Missouri activities over the past several decades, and includes recent results. The nuclear facilities at the University of Missouri (10 MW research reactor and 16.5 MeV GE PETtrace cyclotron) allow research and development into novel theranostic radionuclides. The production, separation, enriched target recovery, radiochemistry, and chelation chemistry of (72,77)As, (186,188)Re and (105)Rh are discussed...
September 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28951881/state-level-implementation-of-health-and-safety-policies-to-prevent-sudden-death-and-catastrophic-injuries-within-secondary-school-athletics
#11
William M Adams, Samantha E Scarneo, Douglas J Casa
BACKGROUND: Sudden death and catastrophic injuries during sport can be attenuated with the implementation of evidence-based health and safety policies. However, the extent of the implementation of these policies within secondary school athletics is unknown. PURPOSE: To provide an assessment of the implementation of health and safety policies pertaining to the leading causes of sudden death and catastrophic injuries in sport within secondary school athletics in the United States...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28945117/assessment-of-closed-point-of-dispensing-pod-preparedness-in-st-louis-county-missouri-2012-2016
#12
Terri Rebmann, John Anthony, Travis M Loux, Julia Mulroy, Rikki Sitzes
Little is known about closed point-of-dispensing (POD) site preparedness-especially how these entities progress in their preparedness efforts over time. The purpose of this study was to assess the preparedness of a closed POD network. Between 2012 and 2016, 30% to 50% of POD entities in the St. Louis County region were assessed each year, for a total of 138 site evaluations from 62 entities. The assessment tool included 41 components of closed POD preparedness, each scored either 0 = not met or 1 = met...
September 25, 2017: Health Security
https://www.readbyqxmd.com/read/28937783/validation-of-the-missouri-osteochondral-allograft-preservation-system-for-the-maintenance-of-osteochondral-allograft-quality-during-prolonged-storage
#13
Aaron M Stoker, James P Stannard, Keiichi Kuroki, Chantelle C Bozynski, Ferris M Pfeiffer, James L Cook
BACKGROUND: Fresh osteochondral allografts (OCAs) are limited in availability. The Missouri Osteochondral Allograft Preservation System (MOPS) has been reported to effectively preserve OCAs twice as long as current tissue bank protocols in preclinical studies. HYPOTHESIS: The viable chondrocyte density (VCD) in OCAs preserved for up to 70 days using the MOPS will not be significantly different from day 0, and the VCD in MOPS-preserved OCAs will be significantly higher than for standard tissue bank preservation...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28933308/polymorphism-gln27glu-of-%C3%AE-2-adrenergic-receptors-in-patients-with-ischaemic-cardiomyopathy
#14
Sofia Metaxa, Constantinos Missouris, Depy Mavrogianni, Antigoni Miliou, Evangelos Oikonomou, Antonios Vlismas, Eirini Toli, Lambrini Kormali, Peter Drakakis, Dimitris Tousoulis
BACKGROUND: Polymorphisms of the adrenergic receptors (ARs) might affect the development and progression of heart failure (HF) and the response to treatment with β-blockade therapy. OBJECTIVE: To examine the role of the Gln27Glu polymorphism of β2-AR in HF development and to assess the hypothesis that Gln27Glu is associated with coronary artery disease in patients with ischaemic HF. METHODS: In this case control study we enrolled 155 consecutive patients with symptomatic HF of ischaemic aetiology with impaired left ventricular ejection fraction (LVEF) ≤35%...
September 19, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28932248/opportunities-for-promoting-physical-activity-in-rural-communities-by-understanding-the-interests-and-values-of-community-members
#15
Thomas Park, Amy A Eyler, Rachel G Tabak, Cheryl Valko, Ross C Brownson
PURPOSE: Physical activity (PA) has well-established health benefits, but most Americans do not meet national guidelines. In southeastern Missouri, trails have been developed to increase rates of PA. Although this has had success, broad-scale interventions will be needed to improve rates further. In this study, we surveyed residents of southeastern Missouri to identify ways to improve rates of PA. METHODS: We conducted a telephone survey in 2015 of adults (n = 524) from eight rural Missouri towns that had walking trails, regarding their activities and interests...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28930067/prenatal-exposure-effects-on-early-adolescent-substance-use-preliminary-evidence-from-a-genetically-informed-bayesian-approach
#16
L Cinnamon Bidwell, Kristine Marceau, Leslie A Brick, Hollis C Karoly, Alexandre A Todorov, Rohan H Palmer, Andrew C Heath, Valerie S Knopik
OBJECTIVE: Given the controversy surrounding the question of whether there are direct or causal effects of exposure to maternal smoking during pregnancy (SDP) on offspring outcomes such as substance use during the adolescent years, we sought to test, on a preliminary basis, within- and between-family associations of SDP and initiation of substance use early in adolescence (by age 15 years) using a discordant sibling design. METHOD: We used a sibling-comparison approach in a sample of 173 families drawn from the state of Missouri, wherein mothers were discordant for smoking behaviors between two different pregnancies, to test for associations of SDP and initiation of substance use in a younger adolescent cohort...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28925076/using-the-robust-design-framework-and-relative-abundance-to-predict-the-population-size-of-pallid-sturgeon-scaphirhynchus-albus-in-the-lower-missouri-river
#17
K D Steffensen, L A Powell, M A Pegg
Several population viability models were constructed to aid recovery in endangered Scaphirhynchus albus, but these models are dependent upon accurate and precise input parameters that are not provided with standard catch per unit effort (CPUE) indices. Nine years of sampling efforts, under the robust design framework, provided 1223 unique captures with an 18·3% recapture rate. The annual population estimates varied from 4·0-7·3 fish rkm(-1) for wild and 8·4-18·4 fish rkm(-1) for hatchery-reared S...
September 18, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28920817/intestinal-histoplasmosis-in-a-captive-reindeer-rangifer-tarandus-missouri-usa
#18
Jessica S Fortin, Michael J Calcutt, Dusty W Nagy, Keiichi Kuroki
An infection with Histoplasma capsulatum was diagnosed in a farmed reindeer in Missouri, an endemic area for histoplasmosis, localized in the intestine. The intrahistiocytic organisms were identified in tissue sections using histologic methods and confirmed by immunohistochemistry. This is the first report of histoplasmosis in a reindeer or in any deer species.
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28917305/genetic-variability-of-cloned-cytauxzoon-felis-ribosomal-rna-its1-and-its2-genomic-regions-from-domestic-cats-with-varied-clinical-outcomes-from-five-states
#19
Dana A Pollard, Mason V Reichard, Leah A Cohn, Andrea M James, Patricia J Holman
Cytauxzoon felis is a tick-borne hemoparasite that causes cytauxzoonosis in domestic cats in the United States. Historically, feline cytauxzoonosis was reported to be nearly always fatal. However, increasing evidence of cats surviving acute infection and/or harboring a chronic, subclinical infection has suggested the existence of different C. felis strains that may vary in pathogenicity. In this study, the intraspecific variation of the C. felis first and second ribosomal RNA internal transcribed spacer (ITS1, ITS2) regions was assessed for any clinical outcome or geographic associations...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28910169/perceptions-of-equid-well-being-in-south-dakota
#20
Lindsey R McNeill, Rebecca C Bott, Sara L Mastellar, Gemechis Djira, Heidi K Carroll
In South Dakota, the status of equid well being is relatively unknown. This study sought to (a) gain understanding about the current perceptions of nonhuman animal well being in South Dakota, with an emphasis on horses and other equids; (b) determine the level of care equids are reportedly receiving and the perceived challenges to equine well being in South Dakota, and (c) determine if people from diverse geographical locations (east or west of the Missouri River) have similar views on the well being of equids in South Dakota...
September 14, 2017: Journal of Applied Animal Welfare Science: JAAWS
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