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https://www.readbyqxmd.com/read/29787962/long-term-outcomes-of-acute-and-transient-psychotic-disorders-the-missed-opportunity-of-preventive-interventions
#1
Grazia Rutigliano, Sergio Merlino, Amedeo Minichino, Rashmi Patel, Cathy Davies, Dominic Oliver, Andrea De Micheli, Philip McGuire, Paolo Fusar-Poli
BACKGROUND: Acute and transient psychotic disorders (ATPD) are characterized by an acute onset and a remitting course, and overlap with subgroups of the clinical high-risk state for psychosis. The long-term course and outcomes of ATPD are not completely clear. METHODS: Electronic health record-based retrospective cohort study, including all patients who received a first index diagnosis of ATPD (F23, ICD-10) within the South London and Maudsley (SLaM) National Health Service Trust, between 1 st April 2006 and 15th June 2017...
May 19, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29751531/computational-analysis-of-the-interaction-energies-between-amino-acid-residues-of-the-measles-virus-hemagglutinin-and-its-receptors
#2
Fengqi Xu, Shigenori Tanaka, Hirofumi Watanabe, Yasuhiro Shimane, Misako Iwasawa, Kazue Ohishi, Tadashi Maruyama
Measles virus (MV) causes an acute and highly devastating contagious disease in humans. Employing the crystal structures of three human receptors, signaling lymphocyte-activation molecule (SLAM), CD46, and Nectin-4, in complex with the measles virus hemagglutinin (MVH), we elucidated computationally the details of binding energies between the amino acid residues of MVH and those of the receptors with an ab initio fragment molecular orbital (FMO) method. The calculated inter-fragment interaction energies (IFIEs) revealed a number of significantly interacting amino acid residues of MVH that played essential roles in binding to the receptors...
May 3, 2018: Viruses
https://www.readbyqxmd.com/read/29729453/the-slam-family-receptors-potential-therapeutic-targets-for-inflammatory-and-autoimmune-diseases
#3
REVIEW
Matthew A Dragovich, Adam Mor
The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors (SLAMF1 through SLAMF9) that are expressed on hematopoietic cells. All of these receptors, with the exception of SLAMF4, are homotypic by nature as downstream signaling occurs when hematopoietic cells that express the same SLAM receptor interact. The SLAM family receptor function is largely controlled via SLAM associated protein (SAP) family adaptors. The SAP family adaptors consist of SAP, Ewing sarcoma associated transcript (EAT)-2, and EAT-2-related transducer (ERT)...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29723975/h-slam-rao-blackwellized-particle-filter-slam-using-hilbert-maps
#4
Guillem Vallicrosa, Pere Ridao
Occupancy Grid maps provide a probabilistic representation of space which is important for a variety of robotic applications like path planning and autonomous manipulation. In this paper, a SLAM (Simultaneous Localization and Mapping) framework capable of obtaining this representation online is presented. The H-SLAM (Hilbert Maps SLAM) is based on Hilbert Map representation and uses a Particle Filter to represent the robot state. Hilbert Maps offer a continuous probabilistic representation with a small memory footprint...
May 1, 2018: Sensors
https://www.readbyqxmd.com/read/29723974/geometric-integration-of-hybrid-correspondences-for-rgb-d-unidirectional-tracking
#5
Shengjun Tang, Wu Chen, Weixi Wang, Xiaoming Li, Walid Darwish, Wenbin Li, Zhengdong Huang, Han Hu, Renzhong Guo
Traditionally, visual-based RGB-D SLAM systems only use correspondences with valid depth values for camera tracking, thus ignoring the regions without 3D information. Due to the strict limitation on measurement distance and view angle, such systems adopt only short-range constraints which may introduce larger drift errors during long-distance unidirectional tracking. In this paper, we propose a novel geometric integration method that makes use of both 2D and 3D correspondences for RGB-D tracking. Our method handles the problem by exploring visual features both when depth information is available and when it is unknown...
May 1, 2018: Sensors
https://www.readbyqxmd.com/read/29702697/slamm-visual-monocular-slam-with-continuous-mapping-using-multiple-maps
#6
Hayyan Afeef Daoud, Aznul Qalid Md Sabri, Chu Kiong Loo, Ali Mohammed Mansoor
This paper presents the concept of Simultaneous Localization and Multi-Mapping (SLAMM). It is a system that ensures continuous mapping and information preservation despite failures in tracking due to corrupted frames or sensor's malfunction; making it suitable for real-world applications. It works with single or multiple robots. In a single robot scenario the algorithm generates a new map at the time of tracking failure, and later it merges maps at the event of loop closure. Similarly, maps generated from multiple robots are merged without prior knowledge of their relative poses; which makes this algorithm flexible...
2018: PloS One
https://www.readbyqxmd.com/read/29701722/cooperative-monocular-based-slam-for-multi-uav-systems-in-gps-denied-environments
#7
Juan-Carlos Trujillo, Rodrigo Munguia, Edmundo Guerra, Antoni Grau
This work presents a cooperative monocular-based SLAM approach for multi-UAV systems that can operate in GPS-denied environments. The main contribution of the work is to show that, using visual information obtained from monocular cameras mounted onboard aerial vehicles flying in formation, the observability properties of the whole system are improved. This fact is especially notorious when compared with other related visual SLAM configurations. In order to improve the observability properties, some measurements of the relative distance between the UAVs are included in the system...
April 26, 2018: Sensors
https://www.readbyqxmd.com/read/29683913/acute-cardiometabolic-responses-to-a-novel-training-rope-protocol-in-children
#8
Avery D Faigenbaum, Jie Kang, Nicholas A Ratamess, Anne Farrell, Stephanie Golda, Andrew Stranieri, Jordan Coe, Jill A Bush
Faigenbaum, AD, Kang, J, Ratamess, NA, Farrell, A, Golda, S, Stranieri, A, Coe, J, and Bush, JA. Acute cardiometabolic responses to a novel training rope protocol in children. J Strength Cond Res 32(5): 1197-1206, 2018-The purpose of this study was to quantify the acute cardiometabolic responses to a novel training rope (TR) protocol in children. Fifteen boys (10.6 ± 1.4 years) were tested for peak oxygen uptake (V[Combining Dot Above]O2) on a treadmill and subsequently (2-7 days later) performed a progressive 10-minute protocol of 5 TR exercises (EX): EX1: standing side-to-side waves, EX2: seated alternating waves, EX3: standing alternating waves, EX4: jumping jacks, and EX5: double-arm slams...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29677276/web-exclusives-annals-story-slam-on-being-vulnerable
#9
J Kevin Dorsey
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677275/web-exclusives-annals-story-slam-perspectives-and-urgency
#10
Yasmina Arroyo-Jimenez
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677274/web-exclusives-annals-story-slam-life-lessons
#11
Megan Miner
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29677273/web-exclusives-annals-story-slam-to-be-or-not-to-be-the-doctor-daughter
#12
Meghna Desai
No abstract text is available yet for this article.
April 17, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29673205/a-closed-form-error-model-of-straight-lines-for-improved-data-association-and-sensor-fusing
#13
Volker Sommer
Linear regression is a basic tool in mobile robotics, since it enables accurate estimation of straight lines from range-bearing scans or in digital images, which is a prerequisite for reliable data association and sensor fusing in the context of feature-based SLAM. This paper discusses, extends and compares existing algorithms for line fitting applicable also in the case of strong covariances between the coordinates at each single data point, which must not be neglected if range-bearing sensors are used. Besides, in particular, the determination of the covariance matrix is considered, which is required for stochastic modeling...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29669250/t-follicular-helper-cell-germinal-center-b-cell-interaction-strength-regulates-entry-into-plasma-cell-or-recycling-germinal-center-cell-fate
#14
Wataru Ise, Kentaro Fujii, Katsuyuki Shiroguchi, Ayako Ito, Kohei Kometani, Kiyoshi Takeda, Eiryo Kawakami, Kazuo Yamashita, Kazuhiro Suzuki, Takaharu Okada, Tomohiro Kurosaki
Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6lo CD69hi expressing a transcription factor IRF4 and higher-affinity B cell receptors (BCRs) or Bcl6hi CD69hi with lower-affinity BCRs, favored the plasma cell or recycling GC cell fate, respectively. Mechanistically, CD40 acted as a dose-dependent regulator for Bcl6lo CD69hi cell formation...
April 17, 2018: Immunity
https://www.readbyqxmd.com/read/29662641/signaling-lymphocytic-activation-molecules-slam-and-cancers-friends-or-foes
#15
REVIEW
Gregory Fouquet, Ingrid Marcq, Véronique Debuysscher, Jagadeesh Bayry, Amrathlal Rabbind Singh, Abderrahmane Bengrine, Eric Nguyen-Khac, Mickael Naassila, Hicham Bouhlal
Signaling Lymphocytic Activation Molecules (SLAM) family receptors are initially described in immune cells. These receptors recruit both activating and inhibitory SH2 domain containing proteins through their Immunoreceptor Tyrosine based Switch Motifs (ITSMs). Accumulating evidence suggest that the members of this family are intimately involved in different physiological and pathophysiological events such as regulation of immune responses and entry pathways of certain viruses. Recently, other functions of SLAM, principally in the pathophysiology of neoplastic transformations have also been deciphered...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29622725/slam-seq-defines-direct-gene-regulatory-functions-of-the-brd4-myc-axis
#16
Matthias Muhar, Anja Ebert, Tobias Neumann, Christian Umkehrer, Julian Jude, Corinna Wieshofer, Philipp Rescheneder, Jesse J Lipp, Veronika A Herzog, Brian Reichholf, David A Cisneros, Thomas Hoffmann, Moritz F Schlapansky, Pooja Bhat, Arndt von Haeseler, Thomas Köcher, Anna C Obenauf, Johannes Popow, Stefan L Ameres, Johannes Zuber
Defining direct targets of transcription factors and regulatory pathways is key to understanding their roles in physiology and disease. Here we combine SLAM-seq, a method for direct quantification of newly synthesized mRNAs, with pharmacological and chemical-genetic perturbation to define regulatory functions of two transcriptional hubs in cancer, BRD4 and MYC, and to interrogate direct responses to BET bromodomain inhibitors (BETi). We find that BRD4 acts as general co-activator of RNA polymerase II (Pol2)-dependent transcription, which is broadly repressed upon high-dose BETi treatment...
April 5, 2018: Science
https://www.readbyqxmd.com/read/29610922/web-exclusives-annals-story-slam-escape-from-iraq-a-refugee-family-s-story-of-resilience-and-hope
#17
Kimberly Carter
No abstract text is available yet for this article.
April 3, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29610921/web-exclusives-annals-story-slam-lessons-from-crying
#18
Karen Alexander
No abstract text is available yet for this article.
April 3, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29610920/web-exclusives-annals-story-slam-just-another-day-in-the-emergency-department
#19
Judd Hollander
No abstract text is available yet for this article.
April 3, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29610919/web-exclusives-annals-story-slam-to-save-one-life-is-to-save-the-world
#20
Dana P Perlman
No abstract text is available yet for this article.
April 3, 2018: Annals of Internal Medicine
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