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https://www.readbyqxmd.com/read/28919493/heat-stress-incident-prevalence-and-tennis-matchplay-performance-at-the-australian-open
#1
Matthew T Smith, Machar Reid, Stephanie Kovalchik, Tim O Woods, Rob Duffield
OBJECTIVES: To examine the association of wet bulb globe temperature (WBGT) with the occurrence of heat-related incidents and changes in behavioural and matchplay characteristics in men's Grand Slam tennis. DESIGN: On-court calls for trainers, doctors, cooling devices and water, post-match medical consults and matchplay characteristic data were collected from 360 Australian Open matches (first 4 rounds 2014-2016). METHODS: Data were referenced against estimated WBGT and categorised into standard zones...
September 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28915651/programmed-differentiated-natural-killer-cells-kill-leukemia-cells-by-engaging-slam-family-receptors
#2
Yang Wu, Young Li, Binqing Fu, Linlin Jin, Xiaohu Zheng, Aimei Zhang, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are important innate immune cells that can directly kill transformed or virus-infected cells. The adoptive transfer of NK cells has been used to treat hematological malignancies; however, the limited sources and quantities of NK cells have restricted their clinical application. Here, we acquired sufficient quantities of functional NK cells from CD34(+) cells treated with a cytokine cocktail. Microarray analysis of the cultured cells revealed a two-stage pattern of programmed differentiation during NK cell development...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28904193/mutations-in-the-fusion-protein-of-measles-virus-that-confer-resistance-to-the-membrane-fusion-inhibitors-carbobenzoxy-d-phe-l-phe-gly-and-as-48
#3
Michael N Ha, Sébastien Delpeut, Ryan S Noyce, Gary Sisson, Karen M Black, Liang-Tzung Lin, Darius Bilimoria, Richard K Plemper, Gilbert G Privé, Christopher D Richardson
The inhibitors Z-d-Phe-l-Phe Gly (fusion inhibitor peptide, FIP) and AS-48 have similar efficacy in blocking membrane fusion and syncytia formation mediated by measles virus. Other homologues such as Z-d-Phe are less effective, but may act through the same mechanism. In an attempt to map the site of action of these inhibitors, we generated mutant viruses which were resistant to the inhibitory effects of Z-d-Phe-l-Phe Gly. These 10 mutations were localized to the heptad repeat region (HRB) of the fusion protein and no changes were observed in the viral hemagglutinin, which is the receptor attachment protein...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28904129/t-cells-regulate-peripheral-naive-mature-b-cell-survival-by-cell-cell-contact-mediated-through-slamf6-and-sap
#4
Lihi Radomir, Sivan Cohen, Matthias P Kramer, Eszter Bakos, Hadas Lewinsky, Avital Barak, Ziv Porat, Richard Bucala, Polina Stepensky, Shirly Becker-Herman, Idit Shachar
The control of lymphoid homeostasis is the result of a very fine balance between lymphocyte production, proliferation, and apoptosis. In this study, we focused on the role of T cells in the maintenance/survival of the mature naive peripheral B cell population. We show that naive B and T cells interact via the signaling lymphocyte activation molecule (SLAM) family receptor, SLAMF6. This interaction induces cell type-specific signals in both cell types, mediated by the SLAM-associated protein (SAP) family of adaptors...
September 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28888925/follicular-helper-t-cells-are-essential-for-the-elimination-of-plasmodium-infection
#5
Damián Pérez-Mazliah, Minh Phuong Nguyen, Caroline Hosking, Sarah McLaughlin, Matthew D Lewis, Irene Tumwine, Prisca Levy, Jean Langhorne
CD4(+) follicular helper T (Tfh) cells have been shown to be critical for the activation of germinal center (GC) B-cell responses. Similar to other infections, Plasmodium infection activates both GC as well as non-GC B cell responses. Here, we sought to explore whether Tfh cells and GC B cells are required to eliminate a Plasmodium infection. A CD4 T cell-targeted deletion of the gene that encodes Bcl6, the master transcription factor for the Tfh program, resulted in complete disruption of the Tfh response to Plasmodium chabaudi in C57BL/6 mice and consequent disruption of GC responses and IgG responses and the inability to eliminate the otherwise self-resolving chronic P...
September 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28873358/-slamming-among-men-who-have-sex-with-men-accessing-general-drug-services-in-response-to-schmidt-aj-et-al-2016-illicit-drug-use-among-gay-and-bisexual-men-in-44-cities-findings-from-the-european-msm-internet-survey-emis
#6
Rachel Glass, Vivian D Hope, Claire Tanner, Monica Desai
No abstract text is available yet for this article.
September 2, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28861453/data-on-the-effect-of-oral-feeding-of-arachidonic-acid-or-docosahexanoic-acid-on-haematopoiesis-in-mice
#7
Kedar Limbkar, Ankita Dhenge, Dipesh D Jadhav, Hirekodathakallu V Thulasiram, Vaijayanti Kale, Lalita Limaye
Stem cells have peculiar property to self-renew and differentiate. It is important to control their fate in safe and effective ways for their therapeutic use. The mediators of essential polyunsaturated fatty acids (PUFAs) namely Arachidonic acid (AA) and Docosahexanoic acid (DHA) are known to play a role in haematopoiesis via various metabolic pathways [1]. However the direct effect of purified AA or DHA on haematopoiesis has not been well investigated yet. We have reported that oral administration of PUFAs enhanced haematopoiesis in mice [2]...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28844660/dermatopontin-in-bone-marrow-extracellular-matrix-regulates-adherence-but-is-dispensable-for-murine-hematopoietic-cell-maintenance
#8
Ashley C Kramer, Amanda L Blake, Mandy E Taisto, Michael J Lehrke, Beau R Webber, Troy C Lund
The hematopoietic marrow microenvironment is composed of multiple cell types embedded in an extracellular matrix (ECM). We have explored marrow ECM using mass spectrometry and found dermatopontin (DPT), a small non-collagenous ECM protein, to be present. We found that DPT cooperates with other ECM proteins to promote hematopoietic cell adherence in vitro on plastic as well as OP9 stromal cells. We generated constitutional DPT(-/-) mice that were viable and had no peripheral lympho-hematopoietic abnormalities...
September 12, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28827385/pillars-article-the-x-linked-lymphoproliferative-disease-gene-product-sap-regulates-signals-induced-through-the-co-receptor-slam-nature-1998-395-462-469
#9
J Sayos, C Wu, M Morra, N Wang, X Zhang, D Allen, S van Schaik, L Notarangelo, R Geha, M G Roncarolo, H Oettgen, J E De Vries, G Aversa, C Terhorst
No abstract text is available yet for this article.
September 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28809694/a-multiple-view-geometric-model-of-specularities-on-non-planar-shapes-with-application-to-dynamic-retexturing
#10
Alexandre Morgand, Mohamed Tamaazousti, Adrien Bartoli
Predicting specularities in images, given the camera pose and scene geometry from SLAM, forms a challenging and open problem. It is nonetheless essential in several applications such as retexturing. A recent geometric model called JOLIMAS partially answers this problem, under the assumptions that the specularities are elliptical and the scene is planar. JOLIMAS models a moving specularity as the image of a fixed 3D quadric. We propose dual JOLIMAS, a new model which raises the planarity assumption. It uses the fact that specularities remain elliptical on convex surfaces and that every surface can be divided in convex parts...
August 10, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28809692/dense-visual-slam-with-probabilistic-surfel-map
#11
Zhixin Yan, Mao Ye, Liu Ren
Visual SLAM is one of the key technologies to align the virtual and real world together in Augmented Reality applications. RGBD dense Visual SLAM approaches have shown their advantages in robustness and accuracy in recent years. However, there are still several challenges such as the inconsistencies in RGBD measurements across multiple frames that could jeopardize the accuracy of both camera trajectory and scene reconstruction. In this paper, we propose a novel map representation called Probabilistic Surfel Map (PSM) for dense visual SLAM...
August 10, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28772581/water-impact-of-syntactic-foams
#12
Adel Shams, Sam Zhao, Maurizio Porfiri
Syntactic foams are particulate composite materials that are extensively integrated in naval and aerospace structures as core materials for sandwich panels. While several studies have demonstrated the potential of syntactic foams as energy absorbing materials in impact tests, our understanding of their response to water impact remains elusive. In this work, we attempt a first characterization of the behavior of a vinyl ester/glass syntactic subject to slamming. High-speed imaging is leveraged to elucidate the physics of water impact of syntactic foam wedges in a free-fall drop tower...
February 23, 2017: Materials
https://www.readbyqxmd.com/read/28757276/value-of-immunohistochemical-expression-of-podocalyxin-in-active-lupus-nephritis
#13
Maha Abdelmoneim Behairy, Marwa Mosaad Shakweer, Tamer Wahid El Said, Nermin Hassan ElGharbawy
Podocalyxin is an electronegative sialoglycoprotein that prevents the podocyte foot process from collapsing. The aim of this study was to detect an association between the glomerular immunohistochemical (IHC) expression of podocalyxin and the degree of podocyte effacement detected by electron microscopy, and to evaluate the role of podocalyxin IHC expression as a novel marker for disease activity in lupus nephritis (LN). METHODS: Thirty-two renal biopsies of active lupus nephritis patients were studied...
July 27, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28751588/travel-ban-would-slam-university-in-north-korea
#14
Richard Stone
No abstract text is available yet for this article.
July 28, 2017: Science
https://www.readbyqxmd.com/read/28710179/omega-3-fatty-acids-fish-oil-supplementation-and-albuminuria-not-a-slam-dunk
#15
EDITORIAL
Sankar D Navaneethan, Salim S Virani
No abstract text is available yet for this article.
July 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28688229/programmed-differentiated-natural-killer-cells-kill-leukemia-cells-by-engaging-slam-family-receptors
#16
Yang Wu, Young Li, Binqing Fu, Linlin Jin, Xiaohu Zheng, Aimei Zhang, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are important innate immune cells that can directly kill transformed or virus-infected cells. The adoptive transfer of NK cells has been used to treat hematological malignancies; however, the limited sources and quantities of NK cells have restricted their clinical application. Here, we acquired sufficient quantities of functional NK cells from CD34+ cells treated with a cytokine cocktail. Microarray analysis of the cultured cells revealed a two-stage pattern of programmed differentiation during NK cell development...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28687543/injury-epidemiology-of-tennis-players-at-the-2011-2016-australian-open-grand-slam
#17
Danielle T Gescheit, Stuart J Cormack, Rob Duffield, Stephanie Kovalchik, Tim O Wood, Melanie Omizzolo, Machar Reid
AIM: To examine the epidemiology and in-event treatment frequency of injury at the 2011-2016 Australian Open tournaments. METHODS: Injury incidence was defined as a medical consultation by a tournament physician and in-event treatment frequency as the mean total number of follow-up medical/physiotherapy consultations (2013-2016 tournaments only). Data were collated by sex, injury region and type and reported as frequencies per 10 000 game exposures. Incidence rate s± 95% CI and rate ratios were used to test effects for injury, sex and year...
September 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28681264/patterns-of-illness-and-care-over-the-5%C3%A2-years-following-onset-of-psychosis-in-different-ethnic-groups-the-gap-5-study
#18
Olesya Ajnakina, John Lally, Marta Di Forti, Anna Kolliakou, Poonam Gardner-Sood, Javier Lopez-Morinigo, Paola Dazzan, Carmine M Pariante, Valeria Mondelli, James MacCabe, Anthony S David, Fiona Gaughran, Robin M Murray, Evangelos Vassos
PURPOSE: Previous research has not provided us with a comprehensive picture of the longitudinal course of psychotic disorders in Black people living in Europe. We sought to investigate clinical outcomes and pattern of care in Black African and Black Caribbean groups compared with White British patients during the first 5 years after first contact with mental health services for psychosis. METHODS: 245 FEP cases aged 18-65 who presented to psychiatric services in 2005-2010 in South London (UK)...
July 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28638731/novel-anti-myeloma-immunotherapies-targeting-the-slam-family-of-receptors
#19
REVIEW
Sabarinath Venniyil Radhakrishnan, Neelam Bhardwaj, Tim Luetkens, Djordje Atanackovic
Treatment for multiple myeloma (MM) has significantly advanced in the last decade with the introduction of proteasome inhibitors and immunomodulatory therapies. Unfortunately, MM continues to cause significant morbidity and most patients eventually succumb to the disease. As in other areas of cancer, immunotherapy in MM has also evolved and holds promise to deliver long-lasting remissions or even cure. The signaling lymphocyte activation molecules (SLAM) family of surface proteins represents a group of potential targets for immunotherapy in MM as some of the family members are expressed consistently on plasma cells and also on myeloma propagating pre-plasma cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28620585/identification-of-a-large-family-of-slam-dependent-surface-lipoproteins-in-gram-negative-bacteria
#20
Yogesh Hooda, Christine C L Lai, Trevor F Moraes
The surfaces of many Gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated N-terminus; these proteins are referred to as surface lipoproteins or SLPs. In Neisseria meningitidis, SLPs such as transferrin-binding protein B (TbpB) and factor-H binding protein (fHbp) are essential for host colonization and infection because of their essential roles in iron acquisition and immune evasion, respectively. Recently, we identified a family of outer membrane proteins called Slam (Surface lipoprotein assembly modulator) that are essential for surface display of neisserial SLPs...
2017: Frontiers in Cellular and Infection Microbiology
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