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https://www.readbyqxmd.com/read/27879298/withdrawals-and-retirements-in-professional-tennis-players-an-analysis-of-2013-united-states-tennis-association-pro-circuit-tournaments
#1
Matthew J Hartwell, Sandra M Fong, Alexis C Colvin
BACKGROUND: Injuries and illnesses for professional tennis athletes disrupt training, competition, and progression in the sport and represent a major reason for athlete withdrawal or retirement from a tournament. Few descriptive epidemiological studies have focused on these trends in elite tennis athletes. PURPOSE: To examine the causes of professional tennis player withdrawal or retirement from United States Tennis Association (USTA) Pro Circuit tournaments during 2013...
November 22, 2016: Sports Health
https://www.readbyqxmd.com/read/27869524/altered-expression-pattern-of-slam-family-receptors-on-pathological-b-cells-of-patients-with-chronic-lymphocytic-leukemia
#2
Matus Coma, Elena Tothova, Tomas Guman, Martina Hajikova, Maria Giertlova, Marek Sarissky
No abstract text is available yet for this article.
November 21, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27815752/hematopoietic-stem-cell-transplantation-for-xiap-deficiency-in-japan
#3
Shintaro Ono, Tsubasa Okano, Akihiro Hoshino, Masakatsu Yanagimachi, Kazuko Hamamoto, Yozo Nakazawa, Toshihiko Imamura, Masaei Onuma, Hidetaka Niizuma, Yoji Sasahara, Hiroshi Tsujimoto, Taizo Wada, Reiko Kunisaki, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane
BACKGROUND: X-linked inhibitor of apoptosis protein (XIAP) deficiency is a rare immunodeficiency that is characterized by recurrent hemophagocytic lymphohistiocytosis (HLH) and splenomegaly and sometimes associated with refractory inflammatory bowel disease (IBD). Although hematopoietic stem cell transplantation (HSCT) is the only curative therapy, the outcomes of HSCT for XIAP deficiency remain unsatisfactory compared with those for SLAM-associated protein deficiency and familial HLH...
November 4, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27782084/measles-to-the-rescue-a-review-of-oncolytic-measles-virus
#4
REVIEW
Sarah Aref, Katharine Bailey, Adele Fielding
Oncolytic virotherapeutic agents are likely to become serious contenders in cancer treatment. The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with increasing evidence of safety and efficacy in early clinical trials. This paramyxovirus vaccine has a proven safety record and is amenable to careful genetic modification in the laboratory. Overexpression of the measles virus (MV) receptor CD46 in many tumour cells may direct the virus to preferentially enter transformed cells and there is increasing awareness of the importance of nectin-4 and signaling lymphocytic activation molecule (SLAM) in oncolysis...
October 22, 2016: Viruses
https://www.readbyqxmd.com/read/27768770/development-of-an-immunoperoxidase-monolayer-assay-for-the-detection-of-antibodies-against-peste-des-petits-ruminants-virus-based-on-bhk-21-cell-line-stably-expressing-the-goat-signaling-lymphocyte-activation-molecule
#5
Jialin Zhang, Wenxing Liu, Weiye Chen, Cuicui Li, Meimei Xie, Zhigao Bu
From 2013 to 2015, peste des petits ruminants (PPR) broke out in more than half of the provinces of China; thus, the application and development of diagnostic methods are very important for the control of PPR. Here, an immunoperoxidase monolayer assay (IPMA) was developed to detect antibodies against PPR. However, during IPMA development, we found that Vero cells were not the appropriate choice because staining results were not easily observed. Therefore, we first established a baby hamster kidney-goat signaling lymphocyte activation molecule (BHK-SLAM) cell line that could stably express goat SLAM for at least 20 generations...
2016: PloS One
https://www.readbyqxmd.com/read/27735857/design-implementation-and-validation-of-the-three-wheel-holonomic-motion-system-of-the-assistant-personal-robot-apr
#6
Javier Moreno, Eduard Clotet, Ruben Lupiañez, Marcel Tresanchez, Dani Martínez, Tomàs Pallejà, Jordi Casanovas, Jordi Palacín
This paper presents the design, implementation and validation of the three-wheel holonomic motion system of a mobile robot designed to operate in homes. The holonomic motion system is described in terms of mechanical design and electronic control. The paper analyzes the kinematics of the motion system and validates the estimation of the trajectory comparing the displacement estimated with the internal odometry of the motors and the displacement estimated with a SLAM procedure based on LIDAR information. Results obtained in different experiments have shown a difference on less than 30 mm between the position estimated with the SLAM and odometry, and a difference in the angular orientation of the mobile robot lower than 5° in absolute displacements up to 1000 mm...
October 10, 2016: Sensors
https://www.readbyqxmd.com/read/27733941/the-implication-of-tissue-doppler-echocardiography-and-cardiopulmonary-exercise-in-early-detection-of-cardiac-dysfunction-in-systemic-lupus-erythematosus-patients
#7
Basant M Elnady, Ayman Saeed Mohamed Abdelghafar, El Shazly Abdul Khalik, Mohammed Mesfer Algethami, A S Basiony, Mona Dhaif Allah Al-Otaibi, Maram Eidhah Al-Otaibi
OBJECTIVE: Systemic lupus erythematosus (SLE) can present limitations to exercise capacity and quality of life (QoL) because of various clinical conditions, such as pulmonary disease or heart disease. Tissue Doppler echocardiography (TDE) offers the promise of an objective measurement to quantify regional and global ventricular function through the assessment of myocardial velocity data. This study aimed to assess the intensity of left ventricular (LV) and right ventricular (RV) systolic and diastolic dysfunction in SLE patients by means of TDE and cardiopulmonary exercise (CPX) testing to determine their impact on QoL...
September 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27730029/matching-range-constrained-real-time-loop-closure-detection-with-cnns-features
#8
Dongdong Bai, Chaoqun Wang, Bo Zhang, Xiaodong Yi, Yuhua Tang
The loop closure detection (LCD) is an essential part of visual simultaneous localization and mapping systems (SLAM). LCD is capable of identifying and compensating the accumulation drift of localization algorithms to produce an consistent map if the loops are checked correctly. Deep convolutional neural networks (CNNs) have outperformed state-of-the-art solutions that use traditional hand-crafted features in many computer vision and pattern recognition applications. After the great success of CNNs, there has been much interest in applying CNNs features to robotic fields such as visual LCD...
2016: Robotics and Biomimetics
https://www.readbyqxmd.com/read/27685095/-sporadic-lymphangioleiomyomatosis-slam-and-tuberous-sclerosis-complex-tsc-pulmonary-manifestations
#9
S Brakemeier, C Grohé, F Bachmann, K Budde
No abstract text is available yet for this article.
September 29, 2016: Pneumologie
https://www.readbyqxmd.com/read/27678536/risk-assessment-and-suicide-by-patients-with-schizophrenia-in-secondary-mental-healthcare-a-case-control-study
#10
Javier-David Lopez-Morinigo, Rosa Ayesa-Arriola, Beatriz Torres-Romano, Andrea C Fernandes, Hitesh Shetty, Matthew Broadbent, Maria-Encarnacion Dominguez-Ballesteros, Robert Stewart, Anthony S David, Rina Dutta
OBJECTIVES: To investigate the role of risk assessment in predicting suicide in patients with schizophrenia spectrum disorders (SSDs) receiving secondary mental healthcare. We postulated that risk assessment plays a limited role in predicting suicide in these patients. DESIGN: Retrospective case-control study. SETTING: Anonymised electronic mental health record data from the South London and Maudsley National Health Service (NHS) Foundation Trust (SLaM) (London, UK) linked with national mortality data...
September 27, 2016: BMJ Open
https://www.readbyqxmd.com/read/27668804/improving-depression-among-hiv-infected-adults-transporting-the-effect-of-a-depression-treatment-intervention-to-routine-care
#11
Angela M Bengtson, Brian W Pence, Bradley N Gaynes, E Byrd Quinlivan, Amy D Heine, Julie K OʼDonnell, Heidi M Crane, W Christopher Mathews, Richard D Moore, Daniel Westreich, Conall OʼCleirigh, Katerina Christopoulos, Matthew J Mimiaga, Michael J Mugavero
BACKGROUND: Depression affects 20%-30% of people with HIV. Randomized controlled trials (RCTs) have demonstrated the effectiveness of interventions to improve depression among HIV-infected adults, but typically have highly selected populations which may limit generalizability. Inverse probability of sampling weights (IPSW) is a recently proposed method to transport (or standardize) findings from RCTs to a specific external target population. METHODS: We used IPSW to transport the 6-month effect of the Measurement-Based Care (MBC) intervention on depression from the SLAM DUNC trial to a population of HIV-infected, depressed adults in routine care in the United States between 2010 and 2014...
December 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27667138/-how-i-manage-igg4-related-disease
#12
Emanuel Della-Torre, John H Stone
IgG4-related disease (IgG4-RD) is an immune-mediated disease driven by interactions on several levels between cells of the B and T lineages. A key driver of IgG4-RD is believed to be a novel CD4+ cytotoxic T lymphocyte that bears SLAM-F7 on its surface. This cell is presumed to be sustained by continuous antigen presentation by cells of the B cell lineage, particularly plasmablasts. Because IgG4-RD has been recognized for fewer than 15 years as a unified diagnostic entity, no controlled clinical trials or few prospective studies of any sort have been performed...
November 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27631153/optimal-interval-for-success-in-judo-world-ranking-competitions
#13
Emerson Franchini, Monica Y Takito, Rodrigo M da Silva, Seihati A Shiroma, Lance Wicks, Ursula F Julio
PURPOSE: was to determine the optimal interval between competitions for success in the different events of the judo world tour. METHODS: A total of 20,916 female and 29,900 male competition participations in the judo world tour competitions disputed between January 2009 and December 2015 were analyzed, considering the dependent variable, winning a medal, and the independent variables, level of competition. RESULTS: there was an increased probability of winning a medal when the interval was in the 10-13 week range for both male and female athletes competing at Grand Prix, Continental Championship and World Championship events, while for Grand Slam only male had increased probability of winning a medal in this interval range...
September 15, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27621421/correction-deletion-of-slam-locus-in-mice-reveals-inhibitory-role-of-slam-family-in-nk-cell-responses-regulated-by-cytokines-and-lfa-1
#14
Huaijian Guo, Stacey A Cranert, Yan Lu, Ming-Chao Zhong, Shaohua Zhang, Jun Chen, Rui Li, Sarah E Mahl, Ning Wu, Dominique Davidson, Stephen N Waggoner, André Veillette
No abstract text is available yet for this article.
September 19, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27616912/three-dimensional-water-impact-at-normal-incidence-to-a-blunt-structure
#15
I K Chatjigeorgiou, M J Cooker, A A Korobkin
The three-dimensional water impact onto a blunt structure with a spreading rectangular contact region is studied. The structure is mounted on a flat rigid plane with the impermeable curved surface of the structure perpendicular to the plane. Before impact, the water region is a rectangular domain of finite thickness bounded from below by the rigid plane and above by the flat free surface. The front free surface of the water region is vertical, representing the front of an advancing steep wave. The water region is initially advancing towards the structure at a constant uniform speed...
August 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27586300/the-x-ray-crystallographic-structure-of-human-eat2-sh2d1b
#16
Mohammed Taha, Eric Nezerwa, Hyun-Joo Nam
Ewing's Sarcoma transcript-2 (EAT2) also known as SH2D1B is involved in regulation of signalling lymphocytic activation molecule (SLAM) family receptor functions. Cytoplasmic tails of SLAM family receptors contain tyrosine residues which mediate the downstream signal transduction through their phosphorylation. EAT2, composed of a single SH2 domain and a short C-terminal tail, binds to the phosphotyrosine residues and regulates SLAM family receptor signalling. We have determined the crystal structure of the human EAT2 protein in an unliganded form...
2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27585353/-sporadic-lymphangioleiomyomatosis-slam-and-tuberous-sclerosis-complex-tsc-pulmonary-manifestations
#17
S Brakemeier, C Grohé, F Bachmann, K Budde
Lymphangioleiomyomatosis (LAM) is a rare multi-system disorder affecting predominantly women of childbearing age. The disease entity is divided in sporadic LAM (sLAM) and LAM associated with tuberous sclerosis complex (TSC). In up to 50 % of female TSC-patients pulmonary involvement (TSC-LAM) can be found, with first clinical symptoms usually starting between 25 and 30 years of age. Progressive deterioration of lung function of 3 - 11 % of diffusion capacity per year has been described, that's why all female TSC patients should be screened for LAM (pulmonary function testing, 6-minute walk test, high-resolution chest CT scan)...
September 1, 2016: Pneumologie
https://www.readbyqxmd.com/read/27577271/rcn-slams-unacceptable-waste-of-bme-talent
#18
Kat Keogh, Petra Kendall-Raynor
Workplace discrimination against black and minority ethnic (BME) nurses and other health workers is an 'astonishing and profoundly unacceptable' waste of talent, the RCN has said.
August 31, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27573813/deletion-of-slam-locus-in-mice-reveals-inhibitory-role-of-slam-family-in-nk-cell-responses-regulated-by-cytokines-and-lfa-1
#19
Huaijian Guo, Stacey A Cranert, Yan Lu, Ming-Chao Zhong, Shaohua Zhang, Jun Chen, Rui Li, Sarah E Mahl, Ning Wu, Dominique Davidson, Stephen N Waggoner, André Veillette
Signaling lymphocytic activation molecule (SLAM) family receptors (SFRs) can mediate either activating or inhibitory effects during natural killer cell (NK cell) activation. In this study, we addressed the global role, regulation, and mechanism of action of the SLAM family in NK cells by analyzing a mouse lacking the entire ∼400-kilobase Slam locus, which encodes all six SFRs and CD48, the ligand of SFR 2B4. This mouse displayed enhanced NK cell activation responses toward hematopoietic target cells. Analyses of mice lacking individual SFRs showed that the inhibitory function of the Slam locus was due solely to 2B4 and was not influenced positively or negatively by other SFRs...
September 19, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27572441/slam-is-an-outer-membrane-protein-that-is-required-for-the-surface-display-of-lipidated-virulence-factors-in-neisseria
#20
Yogesh Hooda, Christine Chieh-Lin Lai, Andrew Judd, Carolyn M Buckwalter, Hyejin Esther Shin, Scott D Gray-Owen, Trevor F Moraes
Lipoproteins decorate the surface of many Gram-negative bacterial pathogens, playing essential roles in immune evasion and nutrient acquisition. In Neisseria spp., the causative agents of gonorrhoea and meningococcal meningitis, surface lipoproteins (SLPs) are required for virulence and have been extensively studied as prime candidates for vaccine development. However, the machinery and mechanism that allow for the surface display of SLPs are not known. Here, we describe a transposon (Tn5)-based search for the proteins required to deliver SLPs to the surface of Neisseria meningitidis, revealing a family of proteins that we have named the surface lipoprotein assembly modulator (Slam)...
2016: Nature Microbiology
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