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https://www.readbyqxmd.com/read/28425946/robot-beacon-distributed-range-only-slam-for-resource-constrained-operation
#1
Arturo Torres-González, Jose Ramiro Martínez-de Dios, Anibal Ollero
This work deals with robot-sensor network cooperation where sensor nodes (beacons) are used as landmarks for Range-Only (RO) Simultaneous Localization and Mapping (SLAM). Most existing RO-SLAM techniques consider beacons as passive devices disregarding the sensing, computational and communication capabilities with which they are actually endowed. SLAM is a resource-demanding task. Besides the technological constraints of the robot and beacons, many applications impose further resource consumption limitations...
April 20, 2017: Sensors
https://www.readbyqxmd.com/read/28424516/slamf7-is-critical-for-phagocytosis-of-haematopoietic-tumour-cells-via-mac-1-integrin
#2
Jun Chen, Ming-Chao Zhong, Huaijian Guo, Dominique Davidson, Sabrin Mishel, Yan Lu, Inmoo Rhee, Luis-Alberto Pérez-Quintero, Shaohua Zhang, Mario-Ernesto Cruz-Munoz, Ning Wu, Donald C Vinh, Meenal Sinha, Virginie Calderon, Clifford A Lowell, Jayne S Danska, André Veillette
Cancer cells elude anti-tumour immunity through multiple mechanisms, including upregulated expression of ligands for inhibitory immune checkpoint receptors. Phagocytosis by macrophages plays a critical role in cancer control. Therapeutic blockade of signal regulatory protein (SIRP)-α, an inhibitory receptor on macrophages, or of its ligand CD47 expressed on tumour cells, improves tumour cell elimination in vitro and in vivo, suggesting that blockade of the SIRPα-CD47 checkpoint could be useful in treating human cancer...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28419512/predicting-receptor-functionality-of-signaling-lymphocyte-activation-molecule-for-measles-virus-hemagglutinin-from-docking-simulation
#3
Yoshiyuki Suzuki
Predicting susceptibility to a virus in various species is desirable for risk assessment of interspecies transmission. For screening of susceptibility, it may be useful to evaluate the receptor functionality. Here the docking simulation was conducted for measles virus hemagglutinin (MV-H) and immunoglobulin-like variable domain of signaling lymphocyte activation molecule (SLAM-V). It wasobserved that the docking score of MV-H and SLAM-V was correlated with the activity of SLAM as MV receptor. These results suggest that the receptor functionality may be predicted from the docking score of virion surface proteins and cellular receptor molecules...
April 17, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28401643/ultrafast-compartmentalized-relaxation-time-mapping-with-linear-algebraic-modeling
#4
Yi Zhang, Xiaoyang Liu, Jinyuan Zhou, Paul A Bottomley
PURPOSE: To dramatically accelerate compartmental-average longitudinal (T1 ) and transverse (T2 ) relaxation measurements using the minimal-acquisition linear algebraic modeling (SLAM) method, and to validate it in phantoms and humans. METHODS: Relaxation times were imaged at 3 Tesla in phantoms, in the abdomens of six volunteers, and in six brain tumor patients using standard inversion recovery and multi-spin-echo sequences. k-space was fully sampled to provide reference T1 and T2 measurements, and SLAM was performed using a limited set of phase encodes from central k-space...
April 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28397758/a-multi-sensorial-simultaneous-localization-and-mapping-slam-system-for-low-cost-micro-aerial-vehicles-in-gps-denied-environments
#5
Elena López, Sergio García, Rafael Barea, Luis M Bergasa, Eduardo J Molinos, Roberto Arroyo, Eduardo Romera, Samuel Pardo
One of the main challenges of aerial robots navigation in indoor or GPS-denied environments is position estimation using only the available onboard sensors. This paper presents a Simultaneous Localization and Mapping (SLAM) system that remotely calculates the pose and environment map of different low-cost commercial aerial platforms, whose onboard computing capacity is usually limited. The proposed system adapts to the sensory configuration of the aerial robot, by integrating different state-of-the art SLAM methods based on vision, laser and/or inertial measurements using an Extended Kalman Filter (EKF)...
April 8, 2017: Sensors
https://www.readbyqxmd.com/read/28397111/gaze-contingent-perceptually-enabled-interactions-in-the-operating-theatre
#6
Alexandros A Kogkas, Ara Darzi, George P Mylonas
PURPOSE: Improved surgical outcome and patient safety in the operating theatre are constant challenges. We hypothesise that a framework that collects and utilises information -especially perceptually enabled ones-from multiple sources, could help to meet the above goals. This paper presents some core functionalities of a wider low-cost framework under development that allows perceptually enabled interaction within the surgical environment. METHODS: The synergy of wearable eye-tracking and advanced computer vision methodologies, such as SLAM, is exploited...
April 10, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28388832/associations-of-baff-and-anti-baff-autoantibodies-with-disease-activity-in-multi-ethnic-asian-systemic-lupus-erythematosus-patients-in-singapore
#7
Hwee Siew Howe, Bernard Y H Thong, Kok Ooi Kong, Hiok Hee Chng, Tsui Yee Lian, Faith L A Chia, Karine S S Tay, Tang Ching Lau, Weng Giap Law, Ee Tzun Koh, Bernard P Leung
OBJECTIVE: To measure the levels of B cell activating factor (BAFF) and endogenous anti-BAFF autoantibodies in a cohort of multi-ethnic Asian systemic lupus erythematosus (SLE) patients in Singapore, to determine their correlation with disease activity. METHODS: Serum samples from 121 SLE patients and 24 age- and sex-matched healthy controls were assayed for BAFF and anti-BAFF IgG antibody levels by ELISA. The lowest reliable detection limit for anti-BAFF-IgG antibody levels was defined as 2 standard deviations (SD) from blank...
April 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28387859/altered-expression-of-signalling-lymphocyte-activation-molecule-receptors-in-t-cells-from-lupus-nephritis-patients-a-potential-biomarker-of-disease-activity
#8
Victoria Stratigou, Anne F Doyle, Francesco Carlucci, Lauren Stephens, Valentina Foschi, Marco Castelli, Nicola McKenna, H Terence Cook, Liz Lightstone, Thomas D Cairns, Matthew C Pickering, Marina Botto
Objectives.: The aim was to investigate whether the signalling lymphocyte activation molecule (SLAM) signalling pathways contribute to LN and whether SLAM receptors could be valuable biomarkers of disease activity. Methods.: Peripheral blood mononuclear cells from 30National Research Ethics Service SLE patients with biopsy-proven LN were analysed by flow cytometry. Clinical measures of disease activity were assessed. The expression of the SLAM family receptors on T-cell subpopulations [CD4, CD8 and double negative (DN) T cells] was measured and compared between lupus patients with active renal disease and those in remission...
April 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/28386908/inhibitory-2b4-contributes-to-nk-cell-education-and-immunological-derangements-in-xlp1-patients
#9
Raffaella Meazza, Michela Falco, Stefania Marcenaro, Fabrizio Loiacono, Paolo Canevali, Francesca Bellora, Claudia Tuberosa, Franco Locatelli, Concetta Micalizzi, Alessandro Moretta, Maria C Mingari, Lorenzo Moretta, Maurizio Aricò, Cristina Bottino, Daniela Pende
X-linked lymphoproliferative disease 1 (XLP1) is an inherited immunodeficiency, caused by mutations in SH2D1A encoding Signaling Lymphocyte Activation Molecule (SLAM)-associated protein (SAP). In XLP1, 2B4, upon engagement with CD48, has inhibitory instead of activating function. This causes a selective inability of cytotoxic effectors to kill EBV-infected cells, with dramatic clinical sequelae. Here, we investigated the NK cell education in XLP1, upon characterization of KIR/KIR-L genotype and phenotypic repertoire of self-HLA class I specific inhibitory receptors (self-iNKR)...
April 6, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28384748/annals-story-slam-when-you-know-what-is-right-there-is-no-decision-the-case-of-a-surgeon-needing-help-at-another-hospital
#10
John M Porter
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28384747/annals-story-slam-humanism-in-medical-education
#11
Anthony J Mazarelli
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28384746/annals-story-slam-my-first-marriage-proposal-%C3%A2-a-lasting-effect
#12
Lisa C Laphan-Morad
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28384745/annals-story-slam-finding-cheeky
#13
Katherine Mayer
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28384744/annals-story-slam-poor-decision-making-at-3-a-m
#14
Brian W Roberts
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28384743/annals-story-slam-harry-and-the-dreaded-hat
#15
Mark Angelo
No abstract text is available yet for this article.
April 4, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28375097/effect-of-total-flavonoids-of-scutellaria-barbata-on-cognitive-function-and-nogo-a-expression-in-the-hippocampus-in-cerebral-ischemia-model-in-gerbils
#16
Yanping Zhang, Yanmei Li
To explore the effect of total flavonoids of Scutellaria barbata on cognitive function and nogo-A expression in the hippocampus region in cerebral ischemia model in gerbils. 30 gerbils were randomly divided into model group, sham operation group, large dose of total flavonoids of Scutellaria barbata group (large dose group), middle dose of total flavonoids of Scutellaria barbata group (middle dose group) and small dose of total flavonoids of Scutellaria barbata group (small dose group), with 6 cases in each group...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28373584/invariant-nkt-cell-activation-is-potentiated-by-homotypic-trans-ly108-interactions
#17
Yuriy Baglaenko, Mayra Cruz Tleugabulova, Eric Gracey, Nafiseh Talaei, Kieran Patricia Manion, Nan-Hua Chang, Dario Michael Ferri, Thierry Mallevaey, Joan E Wither
Invariant NKT (iNKT) cells are innate lymphocytes that respond to glycolipids presented by the MHC class Ib molecule CD1d and are rapidly activated to produce large quantities of cytokines and chemokines. iNKT cell development uniquely depends on interactions between double-positive thymocytes that provide key homotypic interactions between signaling lymphocyte activation molecule (SLAM) family members. However, the role of SLAM receptors in the differentiation of iNKT cell effector subsets and activation has not been explored...
April 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28360254/hospital-admissions-for-respiratory-system-diseases-in-adults-with-intellectual-disabilities-in-southeast-london-a-register-based-cohort-study
#18
Chin-Kuo Chang, Chih-Yin Chen, Mathew Broadbent, Robert Stewart, Jean O'Hara
BACKGROUND: Intellectual disability (ID) carries a high impact on need for care, health status and premature mortality. Respiratory system diseases contribute a major part of mortality among people with ID, but remain underinvestigated as consequent morbidities. METHODS: Anonymised electronic mental health records from the South London and Maudsley Trust (SLaM) were linked to national acute medical care data. Using retrospective cohort and matched case-control study designs, adults with ID receiving SLaM care between 1 January 2008 and 31 March 2013 were identified and compared with local catchment residents for respiratory system disease admissions...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28344876/2b4-sap-signaling-is-required-for-the-priming-of-naive-cd8-t-cells-by-antigen-expressing-b-cells-and-b-lymphoma-cells
#19
Yu-Hsuan Huang, Kevin Tsai, Sara Y Tan, Sohyeong Kang, Mandy L Ford, Kenneth W Harder, John J Priatel
Mutations in SH2D1A gene that encodes SAP (SLAM-associated protein) result in X-linked lymphoproliferative disease (XLP), a rare primary immunodeficiency disease defined by exquisite sensitivity to the B-lymphotropic Epstein-Barr virus (EBV) and B cell lymphomas. However, the precise mechanism of how the loss of SAP function contributes to extreme vulnerability to EBV and the development of B cell lymphomas remains unclear. Here, we investigate the hypothesis that SAP is critical for CD8(+) T cell immune surveillance of antigen (Ag)-expressing B cells or B lymphoma cells under conditions of defined T cell receptor (TCR) signaling...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28336928/expression-of-canine-distemper-virus-receptor-nectin-4-in-the-central-nervous-system-of-dogs
#20
Watanyoo Pratakpiriya, Angeline Ping Ping Teh, Araya Radtanakatikanon, Nopadon Pirarat, Nguyen Thi Lan, Makoto Takeda, Somporn Techangamsuwan, Ryoji Yamaguchi
Canine distemper virus (CDV) exhibits lymphotropic, epitheliotropic, and neurotropic nature, and causes a severe systemic infection in susceptible animals. Initially, signaling lymphocyte activation molecule (SLAM) expressed on immune cells has been identified as a crucial cellular receptor for CDV. Currently, nectin-4 expressed in epithelia has been shown to be another receptor for CDV. Our previous study demonstrated that neurons express nectin-4 and are infected with CDV. In this study, we investigated the distribution pattern of nectin-4 in various cell types in the canine central nervous system and showed its relation to CDV infection to further clarify the pathology of disease...
March 23, 2017: Scientific Reports
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