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https://www.readbyqxmd.com/read/28049627/dissection-of-sap-dependent-and-sap-independent-slam-family-signaling-in-nkt-cell-development-and-humoral-immunity
#1
Shasha Chen, Chenxu Cai, Zehua Li, Guangao Liu, Yuande Wang, Marzenna Blonska, Dan Li, Juan Du, Xin Lin, Meixiang Yang, Zhongjun Dong
Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) mutations in X-linked lymphoproliferative disease (XLP) lead to defective NKT cell development and impaired humoral immunity. Because of the redundancy of SLAM family receptors (SFRs) and the complexity of SAP actions, how SFRs and SAP mediate these processes remains elusive. Here, we examined NKT cell development and humoral immunity in mice completely deficient in SFR. We found that SFR deficiency severely impaired NKT cell development...
January 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28018332/commentary-slam-and-nectin-4-independent-noncytolytic-spread-of-canine-distemper-virus-in-astrocytes
#2
COMMENT
Giovanni Di Guardo, Roberto Giacominelli-Stuffler, Sandro Mazzariol
No abstract text is available yet for this article.
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28003483/adenovirus-serotype-5-vaccination-results-in-suboptimal-cd4-t-helper-1-responses-in-mice
#3
Junghwa Lee, Masao Hashimoto, Se Jin Im, Koichi Araki, Hyun-Tak Jin, Carl W Davis, Bogumila T Konieczny, Gregory A Spies, M Juliana McElrath, Rafi Ahmed
: Adenovirus serotype 5 (Ad5) is one of the most widely used viral vectors and is known to generate potent T cell responses. While many previous studies have characterized Ad5-induced CD8 T cell responses, there is a relative lack of detailed studies analysing CD4 T cells elicited by Ad5 vaccination. Herein, we immunized mice with Ad5 vectors encoding lymphocytic choriomeningitis virus (LCMV)-glycoprotein (GP) and examined GP-specific CD4 T cell responses elicited by Ad5 vectors compared to those induced by an acute LCMV infection...
December 21, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27965413/k-slam-accurate-and-ultra-fast-taxonomic-classification-and-gene-identification-for-large-metagenomic-data-sets
#4
David Ainsworth, Michael J E Sternberg, Come Raczy, Sarah A Butcher
k-SLAM is a highly efficient algorithm for the characterization of metagenomic data. Unlike other ultra-fast metagenomic classifiers, full sequence alignment is performed allowing for gene identification and variant calling in addition to accurate taxonomic classification. A k-mer based method provides greater taxonomic accuracy than other classifiers and a three orders of magnitude speed increase over alignment based approaches. The use of alignments to find variants and genes along with their taxonomic origins enables novel strains to be characterized...
December 13, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27942433/probabilistic-double-guarantee-kidnapping-detection-in-slam
#5
Yang Tian, Shugen Ma
For determining whether kidnapping has happened and which type of kidnapping it is while a robot performs autonomous tasks in an unknown environment, a double guarantee kidnapping detection (DGKD) method has been proposed. The good performance of DGKD in a relative small environment is shown. However, a limitation of DGKD is found in a large-scale environment by our recent work. In order to increase the adaptability of DGKD in a large-scale environment, an improved method called probabilistic double guarantee kidnapping detection is proposed in this paper to combine probability of features' positions and the robot's posture...
2016: Robotics and Biomimetics
https://www.readbyqxmd.com/read/27928865/canine-distemper-virus-in-the-serengeti-ecosystem-molecular-adaptation-to-different-carnivore-species
#6
Veljko M Nikolin, Ximena A Olarte-Castillo, Nikolaus Osterrieder, Heribert Hofer, Edward Dubovi, Camila J Mazzoni, Edgar Brunner, Katja V Goller, Robert D Fyumagwa, Patricia D Moehlman, Dagmar Thierer, Marion L East
Was the 1993/1994 fatal canine distemper virus (CDV) epidemic in lions and spotted hyaenas in the Serengeti ecosystem caused by the recent spillover of a virulent domestic dog strain or one well adapted to these noncanids? We examine this question using sequence data from 13 'Serengeti' strains including five complete genomes obtained between 1993 and 2011. Phylogenetic and haplotype network analyses reveal that strains from noncanids during the epidemic were more closely related to each other than to those from domestic or wild canids...
December 7, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27879298/withdrawals-and-retirements-in-professional-tennis-players-an-analysis-of-2013-united-states-tennis-association-pro-circuit-tournaments
#7
Matthew J Hartwell, Sandra M Fong, Alexis C Colvin
BACKGROUND: Injuries and illnesses for professional tennis athletes disrupt training, competition, and progression in the sport and represent a major reason for athlete withdrawal or retirement from a tournament. Few descriptive epidemiological studies have focused on these trends in elite tennis athletes. PURPOSE: To examine the causes of professional tennis player withdrawal or retirement from United States Tennis Association (USTA) Pro Circuit tournaments during 2013...
November 22, 2016: Sports Health
https://www.readbyqxmd.com/read/27869524/altered-expression-pattern-of-slam-family-receptors-on-pathological-b-cells-of-patients-with-chronic-lymphocytic-leukemia
#8
Matus Coma, Elena Tothova, Tomas Guman, Martina Hajikova, Maria Giertlova, Marek Sarissky
No abstract text is available yet for this article.
November 21, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27815752/hematopoietic-stem-cell-transplantation-for-xiap-deficiency-in-japan
#9
Shintaro Ono, Tsubasa Okano, Akihiro Hoshino, Masakatsu Yanagimachi, Kazuko Hamamoto, Yozo Nakazawa, Toshihiko Imamura, Masaei Onuma, Hidetaka Niizuma, Yoji Sasahara, Hiroshi Tsujimoto, Taizo Wada, Reiko Kunisaki, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane
BACKGROUND: X-linked inhibitor of apoptosis protein (XIAP) deficiency is a rare immunodeficiency that is characterized by recurrent hemophagocytic lymphohistiocytosis (HLH) and splenomegaly and sometimes associated with refractory inflammatory bowel disease (IBD). Although hematopoietic stem cell transplantation (HSCT) is the only curative therapy, the outcomes of HSCT for XIAP deficiency remain unsatisfactory compared with those for SLAM-associated protein deficiency and familial HLH...
November 4, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27782084/measles-to-the-rescue-a-review-of-oncolytic-measles-virus
#10
REVIEW
Sarah Aref, Katharine Bailey, Adele Fielding
Oncolytic virotherapeutic agents are likely to become serious contenders in cancer treatment. The vaccine strain of measles virus is an agent with an impressive range of oncolytic activity in pre-clinical trials with increasing evidence of safety and efficacy in early clinical trials. This paramyxovirus vaccine has a proven safety record and is amenable to careful genetic modification in the laboratory. Overexpression of the measles virus (MV) receptor CD46 in many tumour cells may direct the virus to preferentially enter transformed cells and there is increasing awareness of the importance of nectin-4 and signaling lymphocytic activation molecule (SLAM) in oncolysis...
October 22, 2016: Viruses
https://www.readbyqxmd.com/read/27768770/development-of-an-immunoperoxidase-monolayer-assay-for-the-detection-of-antibodies-against-peste-des-petits-ruminants-virus-based-on-bhk-21-cell-line-stably-expressing-the-goat-signaling-lymphocyte-activation-molecule
#11
Jialin Zhang, Wenxing Liu, Weiye Chen, Cuicui Li, Meimei Xie, Zhigao Bu
From 2013 to 2015, peste des petits ruminants (PPR) broke out in more than half of the provinces of China; thus, the application and development of diagnostic methods are very important for the control of PPR. Here, an immunoperoxidase monolayer assay (IPMA) was developed to detect antibodies against PPR. However, during IPMA development, we found that Vero cells were not the appropriate choice because staining results were not easily observed. Therefore, we first established a baby hamster kidney-goat signaling lymphocyte activation molecule (BHK-SLAM) cell line that could stably express goat SLAM for at least 20 generations...
2016: PloS One
https://www.readbyqxmd.com/read/27735857/design-implementation-and-validation-of-the-three-wheel-holonomic-motion-system-of-the-assistant-personal-robot-apr
#12
Javier Moreno, Eduard Clotet, Ruben Lupiañez, Marcel Tresanchez, Dani Martínez, Tomàs Pallejà, Jordi Casanovas, Jordi Palacín
This paper presents the design, implementation and validation of the three-wheel holonomic motion system of a mobile robot designed to operate in homes. The holonomic motion system is described in terms of mechanical design and electronic control. The paper analyzes the kinematics of the motion system and validates the estimation of the trajectory comparing the displacement estimated with the internal odometry of the motors and the displacement estimated with a SLAM procedure based on LIDAR information. Results obtained in different experiments have shown a difference on less than 30 mm between the position estimated with the SLAM and odometry, and a difference in the angular orientation of the mobile robot lower than 5° in absolute displacements up to 1000 mm...
October 10, 2016: Sensors
https://www.readbyqxmd.com/read/27733941/the-implication-of-tissue-doppler-echocardiography-and-cardiopulmonary-exercise-in-early-detection-of-cardiac-dysfunction-in-systemic-lupus-erythematosus-patients
#13
Basant M Elnady, Ayman Saeed Mohamed Abdelghafar, El Shazly Abdul Khalik, Mohammed Mesfer Algethami, A S Basiony, Mona Dhaif Allah Al-Otaibi, Maram Eidhah Al-Otaibi
OBJECTIVE: Systemic lupus erythematosus (SLE) can present limitations to exercise capacity and quality of life (QoL) because of various clinical conditions, such as pulmonary disease or heart disease. Tissue Doppler echocardiography (TDE) offers the promise of an objective measurement to quantify regional and global ventricular function through the assessment of myocardial velocity data. This study aimed to assess the intensity of left ventricular (LV) and right ventricular (RV) systolic and diastolic dysfunction in SLE patients by means of TDE and cardiopulmonary exercise (CPX) testing to determine their impact on QoL...
September 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27730029/matching-range-constrained-real-time-loop-closure-detection-with-cnns-features
#14
Dongdong Bai, Chaoqun Wang, Bo Zhang, Xiaodong Yi, Yuhua Tang
The loop closure detection (LCD) is an essential part of visual simultaneous localization and mapping systems (SLAM). LCD is capable of identifying and compensating the accumulation drift of localization algorithms to produce an consistent map if the loops are checked correctly. Deep convolutional neural networks (CNNs) have outperformed state-of-the-art solutions that use traditional hand-crafted features in many computer vision and pattern recognition applications. After the great success of CNNs, there has been much interest in applying CNNs features to robotic fields such as visual LCD...
2016: Robotics and Biomimetics
https://www.readbyqxmd.com/read/27685095/-sporadic-lymphangioleiomyomatosis-slam-and-tuberous-sclerosis-complex-tsc-pulmonary-manifestations
#15
S Brakemeier, C Grohé, F Bachmann, K Budde
No abstract text is available yet for this article.
September 29, 2016: Pneumologie
https://www.readbyqxmd.com/read/27678536/risk-assessment-and-suicide-by-patients-with-schizophrenia-in-secondary-mental-healthcare-a-case-control-study
#16
Javier-David Lopez-Morinigo, Rosa Ayesa-Arriola, Beatriz Torres-Romano, Andrea C Fernandes, Hitesh Shetty, Matthew Broadbent, Maria-Encarnacion Dominguez-Ballesteros, Robert Stewart, Anthony S David, Rina Dutta
OBJECTIVES: To investigate the role of risk assessment in predicting suicide in patients with schizophrenia spectrum disorders (SSDs) receiving secondary mental healthcare. We postulated that risk assessment plays a limited role in predicting suicide in these patients. DESIGN: Retrospective case-control study. SETTING: Anonymised electronic mental health record data from the South London and Maudsley National Health Service (NHS) Foundation Trust (SLaM) (London, UK) linked with national mortality data...
September 27, 2016: BMJ Open
https://www.readbyqxmd.com/read/27668804/improving-depression-among-hiv-infected-adults-transporting-the-effect-of-a-depression-treatment-intervention-to-routine-care
#17
Angela M Bengtson, Brian W Pence, Bradley N Gaynes, E Byrd Quinlivan, Amy D Heine, Julie K OʼDonnell, Heidi M Crane, W Christopher Mathews, Richard D Moore, Daniel Westreich, Conall OʼCleirigh, Katerina Christopoulos, Matthew J Mimiaga, Michael J Mugavero
BACKGROUND: Depression affects 20%-30% of people with HIV. Randomized controlled trials (RCTs) have demonstrated the effectiveness of interventions to improve depression among HIV-infected adults, but typically have highly selected populations which may limit generalizability. Inverse probability of sampling weights (IPSW) is a recently proposed method to transport (or standardize) findings from RCTs to a specific external target population. METHODS: We used IPSW to transport the 6-month effect of the Measurement-Based Care (MBC) intervention on depression from the SLAM DUNC trial to a population of HIV-infected, depressed adults in routine care in the United States between 2010 and 2014...
December 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27667138/-how-i-manage-igg4-related-disease
#18
Emanuel Della-Torre, John H Stone
IgG4-related disease (IgG4-RD) is an immune-mediated disease driven by interactions on several levels between cells of the B and T lineages. A key driver of IgG4-RD is believed to be a novel CD4+ cytotoxic T lymphocyte that bears SLAM-F7 on its surface. This cell is presumed to be sustained by continuous antigen presentation by cells of the B cell lineage, particularly plasmablasts. Because IgG4-RD has been recognized for fewer than 15 years as a unified diagnostic entity, no controlled clinical trials or few prospective studies of any sort have been performed...
November 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27631153/optimal-interval-for-success-in-judo-world-ranking-competitions
#19
Emerson Franchini, Monica Y Takito, Rodrigo M da Silva, Seihati A Shiroma, Lance Wicks, Ursula F Julio
PURPOSE: was to determine the optimal interval between competitions for success in the different events of the judo world tour. METHODS: A total of 20,916 female and 29,900 male competition participations in the judo world tour competitions disputed between January 2009 and December 2015 were analyzed, considering the dependent variable, winning a medal, and the independent variables, level of competition. RESULTS: there was an increased probability of winning a medal when the interval was in the 10-13 week range for both male and female athletes competing at Grand Prix, Continental Championship and World Championship events, while for Grand Slam only male had increased probability of winning a medal in this interval range...
September 15, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27621421/correction-deletion-of-slam-locus-in-mice-reveals-inhibitory-role-of-slam-family-in-nk-cell-responses-regulated-by-cytokines-and-lfa-1
#20
Huaijian Guo, Stacey A Cranert, Yan Lu, Ming-Chao Zhong, Shaohua Zhang, Jun Chen, Rui Li, Sarah E Mahl, Ning Wu, Dominique Davidson, Stephen N Waggoner, André Veillette
No abstract text is available yet for this article.
September 19, 2016: Journal of Experimental Medicine
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