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https://www.readbyqxmd.com/read/28710179/omega-3-fatty-acids-fish-oil-supplementation-and-albuminuria-not-a-slam-dunk
#1
EDITORIAL
Sankar D Navaneethan, Salim S Virani
No abstract text is available yet for this article.
July 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28688229/programmed-differentiated-natural-killer-cells-kill-leukemia-cells-by-engaging-slam-family-receptors
#2
Yang Wu, Young Li, Binqing Fu, Linlin Jin, Xiaohu Zheng, Aimei Zhang, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are important innate immune cells that can directly kill transformed or virus-infected cells. The adoptive transfer of NK cells has been used to treat hematological malignancies; however, the limited sources and quantities of NK cells have restricted their clinical application. Here, we acquired sufficient quantities of functional NK cells from CD34+ cells treated with a cytokine cocktail. Microarray analysis of the cultured cells revealed a two-stage pattern of programmed differentiation during NK cell development...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28687543/injury-epidemiology-of-tennis-players-at-the-2011-2016-australian-open-grand-slam
#3
Danielle T Gescheit, Stuart J Cormack, Rob Duffield, Stephanie Kovalchik, Tim O Wood, Melanie Omizzolo, Machar Reid
AIM: To examine the epidemiology and in-event treatment frequency of injury at the 2011-2016 Australian Open tournaments. METHODS: Injury incidence was defined as a medical consultation by a tournament physician and in-event treatment frequency as the mean total number of follow-up medical/physiotherapy consultations (2013-2016 tournaments only). Data were collated by sex, injury region and type and reported as frequencies per 10 000 game exposures. Incidence rate s± 95% CI and rate ratios were used to test effects for injury, sex and year...
July 7, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28681264/patterns-of-illness-and-care-over-the-5%C3%A2-years-following-onset-of-psychosis-in-different-ethnic-groups-the-gap-5-study
#4
Olesya Ajnakina, John Lally, Marta Di Forti, Anna Kolliakou, Poonam Gardner-Sood, Javier Lopez-Morinigo, Paola Dazzan, Carmine M Pariante, Valeria Mondelli, James MacCabe, Anthony S David, Fiona Gaughran, Robin M Murray, Evangelos Vassos
PURPOSE: Previous research has not provided us with a comprehensive picture of the longitudinal course of psychotic disorders in Black people living in Europe. We sought to investigate clinical outcomes and pattern of care in Black African and Black Caribbean groups compared with White British patients during the first 5 years after first contact with mental health services for psychosis. METHODS: 245 FEP cases aged 18-65 who presented to psychiatric services in 2005-2010 in South London (UK)...
July 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28638731/novel-anti-myeloma-immunotherapies-targeting-the-slam-family-of-receptors
#5
REVIEW
Sabarinath Venniyil Radhakrishnan, Neelam Bhardwaj, Tim Luetkens, Djordje Atanackovic
Treatment for multiple myeloma (MM) has significantly advanced in the last decade with the introduction of proteasome inhibitors and immunomodulatory therapies. Unfortunately, MM continues to cause significant morbidity and most patients eventually succumb to the disease. As in other areas of cancer, immunotherapy in MM has also evolved and holds promise to deliver long-lasting remissions or even cure. The signaling lymphocyte activation molecules (SLAM) family of surface proteins represents a group of potential targets for immunotherapy in MM as some of the family members are expressed consistently on plasma cells and also on myeloma propagating pre-plasma cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28620585/identification-of-a-large-family-of-slam-dependent-surface-lipoproteins-in-gram-negative-bacteria
#6
Yogesh Hooda, Christine C L Lai, Trevor F Moraes
The surfaces of many Gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated N-terminus; these proteins are referred to as surface lipoproteins or SLPs. In Neisseria meningitidis, SLPs such as transferrin-binding protein B (TbpB) and factor-H binding protein (fHbp) are essential for host colonization and infection because of their essential roles in iron acquisition and immune evasion, respectively. Recently, we identified a family of outer membrane proteins called Slam (Surface lipoprotein assembly modulator) that are essential for surface display of neisserial SLPs...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28604624/convolutional-neural-network-based-robot-navigation-using-uncalibrated-spherical-images
#7
Lingyan Ran, Yanning Zhang, Qilin Zhang, Tao Yang
Vision-based mobile robot navigation is a vibrant area of research with numerous algorithms having been developed, the vast majority of which either belong to the scene-oriented simultaneous localization and mapping (SLAM) or fall into the category of robot-oriented lane-detection/trajectory tracking. These methods suffer from high computational cost and require stringent labelling and calibration efforts. To address these challenges, this paper proposes a lightweight robot navigation framework based purely on uncalibrated spherical images...
June 12, 2017: Sensors
https://www.readbyqxmd.com/read/28604269/elotuzumab-as-a-novel-anti-myeloma-immunotherapy
#8
Sabarinath Venniyil Radhakrishnan, Neelam Bhardwaj, Mary Steinbach, Janet Weidner, Tim Luetkens, Djordje Atanackovic
Treatment of multiple myeloma has undergone significant change in the last decade with the introduction of new immunomodulatory agents, proteasome inhibitors, and immunotherapeutic approaches. Elotuzumab is a humanized monoclonal antibody targeting CS1, which is a member of the SLAM (Signaling Lymphocyte Activation Molecule) family of proteins, expressed on the surface of myeloma plasma cells. Here we review the preclinical investigations that led to the development of elotuzumab and the clinical studies that resulted in its approval for the treatment of relapsed/refractory multiple myeloma...
June 12, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28593610/brief-report-decreased-expression-of-cd244-slamf4-on-monocytes-and-platelets-in-patients-with-systemic-lupus-erythematosus
#9
Anselm Mak, Susannah I Thornhill, Hui Yin Lee, Bernett Lee, Michael Poidinger, John E Connolly, Anna-Marie Fairhurst
The signalling lymphocyte activation molecule (SLAM) family receptors play important roles in modulating immune responses. Previous studies in murine models and patients have suggested an association of the SLAM family (SLAMF) members with the development of autoimmunity, particularly systemic lupus erythematosus (SLE). Since previous investigations on CD244 expression have focussed on NK and T cells, the aim of this study was to evaluate the surface expression of major SLAMF members across monocytes and polymorphonuclear cells in an Asian SLE cohort and explore their potential associations with SLE-related disease activity and autoantibodies...
June 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28570968/sources-of-nitrogen-and-phosphorus-emissions-to-irish-rivers-and-coastal-waters-estimates-from-a-nutrient-load-apportionment-framework
#10
Eva M Mockler, Jenny Deakin, Marie Archbold, Laurence Gill, Donal Daly, Michael Bruen
More than half of surface water bodies in Europe are at less than good ecological status according to Water Framework Directive assessments, and diffuse pollution from agriculture remains a major, but not the only, cause of this poor performance. Agri-environmental policy and land management practices have, in many areas, reduced nutrient emissions to water. However, additional measures may be required in Ireland to further decouple the relationship between agricultural productivity and emissions to water, which is of vital importance given on-going agricultural intensification...
May 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531135/aekf-slam-a-new-algorithm-for-robotic-underwater-navigation
#11
Xin Yuan, José-Fernán Martínez-Ortega, José Antonio Sánchez Fernández, Martina Eckert
In this work, we focus on key topics related to underwater Simultaneous Localization and Mapping (SLAM) applications. Moreover, a detailed review of major studies in the literature and our proposed solutions for addressing the problem are presented. The main goal of this paper is the enhancement of the accuracy and robustness of the SLAM-based navigation problem for underwater robotics with low computational costs. Therefore, we present a new method called AEKF-SLAM that employs an Augmented Extended Kalman Filter (AEKF)-based SLAM algorithm...
May 21, 2017: Sensors
https://www.readbyqxmd.com/read/28527025/pose-aware-c-arm-for-automatic-re-initialization-of-interventional-2d-3d-image-registration
#12
Javad Fotouhi, Bernhard Fuerst, Alex Johnson, Sing Chun Lee, Russell Taylor, Greg Osgood, Nassir Navab, Mehran Armand
PURPOSE: In minimally invasive interventions assisted by C-arm imaging, there is a demand to fuse the intra-interventional 2D C-arm image with pre-interventional 3D patient data to enable surgical guidance. The commonly used intensity-based 2D/3D registration has a limited capture range and is sensitive to initialization. We propose to utilize an opto/X-ray C-arm system which allows to maintain the registration during intervention by automating the re-initialization for the 2D/3D image registration...
July 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28525793/-almost-a-slam-dunk-assessing-the-experiences-and-opinions-of-participants-in-a-national-basketball-association-nba-funded-dropout-prevention-program
#13
Tray J Geiger, Audrey Amrein-Beardsley
Researchers conducted an evaluation of participants' perceptions of a dropout prevention program - the NBA High School program - involving a National Basketball Association (NBA) team, a high school located in downtown [City], and the College of Education (COE) at the local State University (SU). The program targeted "at-risk" high school students while utilizing student-teachers as tutors and mentors. Researchers utilized mixed methods to assess student, student-teacher, and high school teacher participants' experiences with and opinions of the program...
October 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28521384/analysis-of-tenodesis-techiques-for-treatment-of-scapholunate-instability-using-the-finite-element-method
#14
Teresa Alonso Rasgado, Qinghang Zhang, David Jimenez Cruz, Colin Bailey, Elizabeth Pinder, Avanthi Mandaleson, Sumedh Talwalkar
Chronic Scapholunate ligament (SL) injuries are difficult to treat and can lead to wrist dysfunction. Whilst several tendon reconstruction techniques have been employed in the management of SL instability, SL gap reappearance after surgery has been reported. Using finite element model and cadaveric study data we investigated the performance of the Corella, schapolunate axis (SLAM) and modified Brunelli tenodesis (MBT) techniques. Virtual tenodesis surgery was undertaken in 3D finite element (FE) models to obtain the scapholunate (SL) gap and angle resulting from the three reconstruction techniques...
May 18, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28508345/deep-monocular-3d-reconstruction-for-assisted-navigation-in-bronchoscopy
#15
Marco Visentini-Scarzanella, Takamasa Sugiura, Toshimitsu Kaneko, Shinichiro Koto
PURPOSE: In bronchoschopy, computer vision systems for navigation assistance are an attractive low-cost solution to guide the endoscopist to target peripheral lesions for biopsy and histological analysis. We propose a decoupled deep learning architecture that projects input frames onto the domain of CT renderings, thus allowing offline training from patient-specific CT data. METHODS: A fully convolutional network architecture is implemented on GPU and tested on a phantom dataset involving 32 video sequences and [Formula: see text]60k frames with aligned ground truth and renderings, which is made available as the first public dataset for bronchoscopy navigation...
July 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28460404/annals-story-slam-sit-up-straight
#16
Karole Collier
No abstract text is available yet for this article.
May 2, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28460403/annals-story-slam-the-problematic-prayer
#17
Stephen Ludwig
No abstract text is available yet for this article.
May 2, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28460402/annals-story-slam-the-uncomfortable-role
#18
Hayley Goldbach
No abstract text is available yet for this article.
May 2, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28460401/annals-story-slam-fallible
#19
Vidya B Viswanathan
No abstract text is available yet for this article.
May 2, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28460400/annals-story-slam-summertime-and-the-living-is-easy
#20
Jerry Johnson
No abstract text is available yet for this article.
May 2, 2017: Annals of Internal Medicine
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