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https://www.readbyqxmd.com/read/29340975/epidemiology-of-injuries-in-tennis-players
#1
REVIEW
Michael C Fu, Todd S Ellenbecker, Per A Renstrom, Gary S Windler, David M Dines
PURPOSE OF REVIEW: To review the recent literature regarding the epidemiology of tennis injuries at all levels of play, and to discuss recent findings in injury surveillance by the Association of Tennis Professionals (ATP). RECENT FINDINGS: Following the release of a consensus statement in 2009 calling for standardized documentation and analysis of tennis-related injuries, multiple studies have been published describing longitudinal injury incidences at Grand Slam tournaments and the Davis Cup...
January 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29337666/tuning-of-in-vivo-cognate-b-t-cell-interactions-by-intersectin-2-is-required-for-effective-anti-viral-b-cell-immunity
#2
Marianne Burbage, Francesca Gasparrini, Shweta Aggarwal, Mauro Gaya, Johan Arnold, Usha Nair, Michael Way, Andreas Bruckbauer, Facundo D Batista
Wiskott-Aldrich syndrome (WAS) is an immune pathology associated with mutations in WAS protein (WASp) or in WASp interacting protein (WIP). Together with the small GTPase Cdc42 and other effectors, these proteins participate in the remodelling of the actin network downstream of BCR engagement. Here we show that mice lacking the adaptor protein ITSN2, a G-nucleotide exchange factor (GEF) for Cdc42 that also interacts with WASp and WIP, exhibited increased mortality during primary infection, incomplete protection after Flu vaccination, reduced germinal centre formation and impaired antibody responses to vaccination...
January 16, 2018: ELife
https://www.readbyqxmd.com/read/29326986/measles-virus-background-and-oncolytic-virotherapy
#3
REVIEW
Sankhajit Bhattacharjee, Pramod Kumar Yadava
Measles is a highly transmissible disease caused by measles virus and remains a major cause of child mortality in developing countries. Measles virus nucleoprotein (N) encapsidates the RNA genome of the virus for providing protection from host cell endonucleases and for specific recognition of viral RNA as template for transcription and replication. This protein is over-expressed at the time of viral replication. The C-terminal of N protein is intrinsically disordered, which enables this protein to interact with several host cell proteins...
March 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29317395/the-role-of-elotuzumab-in-the-treatment-of-relapsed-or-refractory-multiple-myeloma
#4
REVIEW
Jill M Comeau, Katherine Kelly, Gary W Jean
PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy and safety, cost, and place in therapy of elotuzumab for treatment of relapsed or refractory multiple myeloma (MM) are reviewed. SUMMARY: Elotuzumab is a humanized monoclonal antibody that targets the signaling lymphocytic activation molecule (SLAM) protein SLAMF7 and facilitates an antibody-dependent cellular cytotoxicity interaction between myeloma cells and natural killer cells. Elotuzumab has U.S...
January 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29305520/soluble-slamf6-receptor-induces-strong-cd8-t-cell-effector-function-and-improves-anti-melanoma-activity-in-vivo
#5
Galit Eisenberg, Roni Engelstein, Anat Geiger, Emma Hajaj, Sharon Merims, Shoshana Frankenburg, Ronny Uzana, Abraham Rutenberg, Arthur Machlenkin, Gabi Frei, Tamar Peretz, Michal Lotem
SLAMF6, a member of the SLAM (signaling lymphocyte activation molecules) family, is a homotypic-binding immune receptor expressed on NK, T, and B lymphocytes. Phosphorylation variance between T-cell subclones prompted us to explore its role in anti-melanoma immunity. Using a 203-amino acid sequence of the human SLAMF6 (seSLAMF6) ectodomain, we found that seSLAMF6 reduced activation-induced cell death and had an anti-apoptotic effect on tumor infiltrating lymphocytes. CD8+ T cells costimulated with seSLAMF6 secreted more interferon gamma and displayed augmented cytolytic activity...
January 5, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29298883/cell-to-cell-measles-virus-spread-between-human-neurons-dependent-on-the-hemagglutinin-and-the-hyperfusogenic-fusion-protein
#6
Yuma Sato, Shumpei Watanabe, Yoshinari Fukuda, Takao Hashiguchi, Yusuke Yanagi, Shinji Ohno
Measles virus (MV) usually causes acute infection, but in rare cases persists in the brain, resulting in subacute sclerosing panencephalitis (SSPE). Since human neurons, an important target affected in the disease, do not express the known MV receptors (signaling lymphocyte activation molecule (SLAM) and nectin 4), how MV infects neurons and spreads between them is unknown. Recent studies have shown that many virus strains isolated from SSPE patients possess substitutions in the extracellular domain of the fusion (F) protein which confer enhanced fusion activity...
January 3, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29279163/diagnostic-properties-of-the-spiquestionnaire-to-detect-posterior-circumflex-humeral-artery-disease-in-elite-volleyball-players-a-cross-sectional-study
#7
Olivier V A Bouwmeester, Daan van de Pol, P Paul F M Kuijer, R Nils Planken, Aart Terpstra, Marja Pannekoek-Hekman, Sena Alaeikhanehshir, Mario Maas
OBJECTIVES: Sports related aneurysmal degeneration and thrombosis of the Posterior Circumflex Humeral Artery (PCHA) has been known to cause symptoms of digital ischemia (DI) in elite volleyball players. Studies have reported symptoms of DI in as much as 28% of the elite indoor volleyball players. The purpose of this study was to determine the diagnostic value of the Shoulder PCHA Pathology and digital Ischemia - Questionnaire (SPI-Q) for detection of sports related PCHA disease using ultrasound data as the standard of reference...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29262493/-genetic-characterization-of-rubella-virus-isolated-in-guizhou-province-from-2012-to-2015
#8
X M Tang, Z Zhu, G Ren, X F Ye, L Zhang
Objective: To analyze the genetic characteristics of rubella virus isolated from 2012 to 2015 in Guizhou province. Methods: A total of 390 cases of suspected measles were collected from Guizhou measles network laboratory from 2012 to 2015 and 25 cases of rubella cases were diagnosed. Rubella virus isolation was performed using Vero/SLAM cells. The presence of rubella viral RNA was detected using Real-time RT-PCR after RNA extraction from infected tissue culture cells. Fragments of 480 bp and 633 bp nucleotides of E1 genes of the isolates were amplified by RT-PCR and the PCR products were sequenced and spliced...
December 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29250588/a-non-rigid-map-fusion-based-direct-slam-method-for-endoscopic-capsule-robots
#9
Mehmet Turan, Yasin Almalioglu, Helder Araujo, Ender Konukoglu, Metin Sitti
Since the development of capsule endoscopy technology, medical device companies and research groups have made significant progress to turn passive capsule endoscopes into robotic active capsule endoscopes. However, the use of robotic capsules in endoscopy still has some challenges. One such challenge is the precise localization of the actively controlled robot in real-time. In this paper, we propose a non-rigid map fusion based direct simultaneous localization and mapping method for endoscopic capsule robots...
2017: International Journal of Intelligent Robotics and Applications
https://www.readbyqxmd.com/read/29238248/comparing-matchplay-characteristics-and-physical-demands-of-junior-and-professional-tennis-athletes-in-the-era-of-big-data
#10
Stephanie A Kovalchik, Machar Reid
Differences in the competitive performance characteristics of junior and professional tennis players are not well understood. The present study provides a comprehensive comparative analysis of junior and professional matchplay. The study utilized multiple large-scale datasets covering match, point, and shot outcomes over multiple years of competition. Regression analysis was used to identify differences between junior and professional matchplay. Top professional men and women were found to play significantly more matches, sets, and games compared to junior players of an equivalent ranking...
December 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29213234/cognitive-mapping-based-on-conjunctive-representations-of-space-and-movement
#11
Taiping Zeng, Bailu Si
It is a challenge to build robust simultaneous localization and mapping (SLAM) system in dynamical large-scale environments. Inspired by recent findings in the entorhinal-hippocampal neuronal circuits, we propose a cognitive mapping model that includes continuous attractor networks of head-direction cells and conjunctive grid cells to integrate velocity information by conjunctive encodings of space and movement. Visual inputs from the local view cells in the model provide feedback cues to correct drifting errors of the attractors caused by the noisy velocity inputs...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/29206227/slam-protein-dictates-subcellular-localization-and-translation-of-its-own-mrna
#12
Shuling Yan, Sreemukta Acharya, Stephanie Gröning, Jörg Großhans
Many mRNAs specifically localize within the cytoplasm and are present in RNA-protein complexes. It is generally assumed that localization and complex formation of these RNAs are controlled by trans-acting proteins encoded by genes different than the RNAs themselves. Here, we analyze slow as molasses (slam) mRNA that prominently colocalizes with its encoded protein at the basal cortical compartment during cellularization. The functional implications of this striking colocalization have been unknown. Here, we show that slam mRNA translation is spatiotemporally controlled...
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29186843/a-2-5d-map-based-mobile-robot-localization-via-cooperation-of-aerial-and-ground-robots
#13
Tae Hyeon Nam, Jae Hong Shim, Young Im Cho
Recently, there has been increasing interest in studying the task coordination of aerial and ground robots. When a robot begins navigation in an unknown area, it has no information about the surrounding environment. Accordingly, for robots to perform tasks based on location information, they need a simultaneous localization and mapping (SLAM) process that uses sensor information to draw a map of the environment, while simultaneously estimating the current location of the robot on the map. This paper aims to present a localization method based in cooperation between aerial and ground robots in an indoor environment...
November 25, 2017: Sensors
https://www.readbyqxmd.com/read/29178063/evaluation-of-the-performance-of-three-tenodesis-techniques-for-the-treatment-of-scapholunate-instability-flexion-extension-and-radial-ulnar-deviation
#14
Teresa Alonso-Rasgado, Qing-Hang Zhang, David Jimenez-Cruz, Colin Bailey, Elizabeth Pinder, Avanthi Mandaleson, Sumedh Talwalkar
Chronic scapholunate ligament (SL) injuries are difficult to treat and can lead to wrist dysfunction. Whilst several tendon reconstruction techniques have been employed in the management of SL instability, SL gap reappearance after surgery has been reported. Using a finite element model and cadaveric study data, we investigated the performance of the Corella, scapholunate axis (SLAM) and modified Brunelli tenodesis (MBT) techniques. Scapholunate dorsal and volar gap and angle were obtained following virtual surgery undertaken using each of the three reconstruction methods with the wrist positioned in flexion, extension, ulnar deviation and radial deviation, in addition to the ulnar-deviated clenched fist and neutral positions...
November 25, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29169925/heat-stress-incidence-and-matchplay-characteristics-in-women-s-grand-slam-tennis
#15
Matthew T Smith, Machar Reid, Stephanie Kovalchik, Tim Wood, Rob Duffield
OBJECTIVES: To explore the relationship of wet bulb globe temperature (WBGT) on heat-related incidents and alterations in matchplay and behavioural characteristics in women's tennis at the Australian Open. DESIGN: From 360 main draw Australian Open women's matches (2014-2016), data describing on-court calls for trainers, doctors, cooling devices and water, post match medical consults and matchplay characteristics were collated. METHODS: Data were referenced against estimated WBGT and categorised into standard zones (zone 5: >32...
November 15, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29157260/high-resolution-and-accelerated-multi-parametric-mapping-with-automated-characterization-of-vessel-disease-using-intravascular-mri
#16
Guan Wang, Yi Zhang, Shashank Sathyanarayana Hegde, Paul A Bottomley
BACKGROUND: Atherosclerosis is prevalent in cardiovascular disease, but present imaging modalities have limited capabilities for characterizing lesion stage, progression and response to intervention. This study tests whether intravascular magnetic resonance imaging (IVMRI) measures of relaxation times (T1, T2) and proton density (PD) in a clinical 3 Tesla scanner could characterize vessel disease, and evaluates a practical strategy for accelerated quantification. METHODS: IVMRI was performed in fresh human artery segments and swine vessels in vivo, using fast multi-parametric sequences, 1-2 mm diameter loopless antennae and 200-300 μm resolution...
November 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29141658/thioredoxin-mitigates-radiation-induced-hematopoietic-stem-cell-injury-in-mice
#17
Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J Chen, Phuong L Doan, Nelson J Chao, Yubin Kang
BACKGROUND: Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HSCs) from radiation injury is an important goal in the development of medical countermeasure agents (MCM). We recently identified thioredoxin (TXN) as a novel molecule that has marked protective and proliferative effects on HSCs. In the current study, we investigated the effectiveness of TXN in rescuing mice from a lethal dose of total body radiation (TBI) and in enhancing hematopoietic reconstitution following a lethal dose of irradiation...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29135966/monocular-visual-inertial-slam-continuous-preintegration-and-reliable-initialization
#18
Yi Liu, Zhong Chen, Wenjuan Zheng, Hao Wang, Jianguo Liu
In this paper, we propose a new visual-inertial Simultaneous Localization and Mapping (SLAM) algorithm. With the tightly coupled sensor fusion of a global shutter monocular camera and a low-cost Inertial Measurement Unit (IMU), this algorithm is able to achieve robust and real-time estimates of the sensor poses in unknown environment. To address the real-time visual-inertial fusion problem, we present a parallel framework with a novel IMU initialization method. Our algorithm also benefits from the novel IMU factor, the continuous preintegration method, the vision factor of directional error, the separability trick and the robust initialization criterion which can efficiently output reliable estimates in real-time on modern Central Processing Unit (CPU)...
November 14, 2017: Sensors
https://www.readbyqxmd.com/read/29129527/identification-of-measles-virus-genotype-b3-associated-with-outbreaks-in-islamabad-pakistan-2013-2015
#19
Syed Sohail Zahoor Zaidi, Abdul Hameed, Muhammad Suleman Rana, Muhammad Masroor Alam, Massab Umair, Uzma Bashir Aamir, Maqbool Hussain, Salmaan Sharif, Shahzad Shaukat, Mehar Angez, Adnan Khurshid
BACKGROUND: Measles virus infection remains a significant cause of childhood mortality and morbidity despite continued global efforts and the availability of a safe and effective vaccine. Molecular analysis of indigenous measles viruses could provide critical information on outbreak linkages and transmission pathways that can aid the implementation of appropriate control programs in Pakistan. METHODS: Blood samples and throat swabs were collected from subjects suspected with measles in Islamabad, Pakistan from 2013 to 2015...
November 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29122202/human-responses-to-wave-slamming-vibration-on-a-polar-supply-and-research-vessel
#20
H Omer, A Bekker
A polar supply and research vessel is pre-disposed to wave slamming which has caused complaints among crew and researchers regarding interference with sleep, equipment use and research activities. The present work undertook to survey passenger claims of sleep interference, disturbed motor tasks and equipment damage as a result of wave slamming during normal operations of this vessel. The hypothesis was investigated that whole-body vibration metrics from ISO 2631-1 are potentially suitable for the prediction of human slamming complaints...
February 2018: Applied Ergonomics
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