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https://www.readbyqxmd.com/read/28322502/mystery-solved-our-son-s-autism-and-extreme-self-injury-is-genetic-and-treatable
#1
Tanja Bartel
Our 17-year-old autistic son Jake is declining at the same rate his peers are developing. He has the pimples, the sudden height, and the hormones. But the right side of his body slumps like someone who has had a stroke. Once right handed, he now uses only his left hand. At 15, he knocked his eyes off their parallel tracks by slamming his temple into the corner of a wooden post. One eye looks straight ahead while the other looks up and to the side. Both optic nerves are damaged. All the damage is self-inflicted...
March 21, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28320671/an-indoor-wayfinding-system-based-on-geometric-features-aided-graph-slam-for-the-visually-impaired
#2
He Zhang, Cang Ye
This paper presents a 6-DOF pose estimation (PE) method and an indoor wayfinding system based on the method for the visually impaired. The PE method involves two graph SLAM processes to reduce the accumulative pose error of the device. In the first step, the floor plane is extracted from the 3D camera's point cloud and added as a landmark node into the graph for 6-DOF SLAM to reduce roll, pitch and Z errors. In the second step, the wall lines are extracted and incorporated into the graph for 3-DOF SLAM to reduce X, Y and yaw errors...
March 15, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28315353/crystal-structure-of-the-extracellular-domain-of-the-human-dendritic-cell-surface-marker-cd83
#3
Christiane S Heilingloh, Stefan Klingl, Claudia Egerer-Sieber, Benedikt Schmid, Sigrid Weiler, Petra Mühl-Zürbes, Jörg Hofmann, Joachim D Stump, Heinrich Sticht, Mirko Kummer, Alexander Steinkasserer, Yves A Muller
CD83 is a type-I membrane protein and an efficient marker for identifying mature dendritic cells. Whereas membrane-bound full-length CD83 co-stimulates the immune system, a soluble variant (sCD83), consisting of the extracellular domain, only, displays strong immune-suppressive activities. Besides a prediction that sCD83 adopts a V-set Ig-like fold, however, little is known about the molecular architecture of CD83 and the mechanism by which CD83 exerts is function on dendritic cells and additional immune cells...
March 14, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28293972/a-comparison-of-patients-and-physicians-assessments-of-disease-activity-using-the-swedish-version-of-the-systemic-lupus-activity-questionnaire
#4
S Pettersson, E Svenungsson, J Gustafsson, S Möller, I Gunnarsson, E Welin Henriksson
OBJECTIVES: We compared patients' assessments of systemic lupus erythematosus (SLE) disease activity by a Swedish version of the Systemic Lupus Activity Questionnaire (SLAQ) with physicians' assessments by the Systemic Lupus Activity Measure (SLAM) and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). We also explored the performance of the SLAQ in patients with short (< 1 year) versus long (≥ 1 year) disease duration. METHOD: Patients filled out the SLAQ before physicians' assessments...
March 15, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28279995/what-proportion-of-patients-with-psychosis-is-willing-to-take-part-in-research-a-mental-health-electronic-case-register-analysis
#5
Rashmi Patel, Sherifat Oduola, Felicity Callard, Til Wykes, Matthew Broadbent, Robert Stewart, Thomas K J Craig, Philip McGuire
OBJECTIVE: The proportion of people with mental health disorders who participate in clinical research studies is much smaller than for those with physical health disorders. It is sometimes assumed that this reflects an unwillingness to volunteer for mental health research studies. We examined this issue in a large sample of patients with psychosis. DESIGN: Cross-sectional study. SETTING: Anonymised electronic mental health record data from the South London and Maudsley NHS Foundation Trust (SLaM)...
March 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28265676/annals-on-being-a-doctor-story-slam-what-does-one-remember-after-a-long-medical-career
#6
Eliot Nierman
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265675/annals-on-being-a-doctor-story-slam-finding-the-reason
#7
Navin Vij
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265674/annals-on-being-a-doctor-story-slam-eeyore-and-tigger
#8
Benjamin Khazan
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265673/annals-on-being-a-doctor-story-slam-the-wait
#9
Linda Jara
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265672/annals-on-being-a-doctor-story-slam-just-listen
#10
Lawrence I Kaplan
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265671/annals-on-being-a-doctor-story-slam-reframe
#11
Michael Bohannan-Calloway
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265670/annals-on-being-a-doctor-story-slam-how-to-treat-blue-waffle-disease
#12
Anita Ravi
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265669/annals-on-being-a-doctor-story-slam-everyday-wow
#13
Lorenita Lucas
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265668/annals-on-being-a-doctor-story-slam-the-social-and-family-history-of-a-physician-in-training
#14
Anna Morgan
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28265667/annals-on-being-a-doctor-story-slam-30-days-dead-or-cured
#15
David Mayer Smith
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28255437/effects-of-a-smoking-ban-on-clozapine-plasma-concentrations-in-a-nonsecure-psychiatric-unit
#16
Siobhan H Gee, David M Taylor, Sukhwinder S Shergill, Robert Flanagan, James H MacCabe
BACKGROUND: Tobacco smoke is known to affect plasma levels of some drugs, including the antipsychotic clozapine. The effects of suddenly stopping smoking on patients who take clozapine can be severe, as plasma concentrations are expected to rapidly rise, potentially leading to toxicity. A ban on smoking at South London and the Maudsley NHS Foundation Trust (SLaM) was implemented in 2014, and this was expected to affect the plasma concentrations of clozapine for inpatients at the time...
February 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28250158/binding-of-platelets-to-lymphocytes-a-potential-anti-inflammatory-therapy-in-rheumatoid-arthritis
#17
Carlos Zamora, Elisabet Cantó, Juan C Nieto, Jorge Bardina, Cesar Diaz-Torné, Patricia Moya, Berta Magallares, M Angels Ortiz, Germà Julià, Candido Juarez, Josep M Llobet, Silvia Vidal
Soluble factors released from platelets can modulate the immune response of leukocytes. We and others have recently found that T lymphocytes with bound platelets have reduced proliferation and IFN-γ and IL-17 production. Thus, we speculate that if we induce the binding of platelets to lymphocytes, we will be able to regulate the inflammatory response. When we cocultured platelets with lymphocytes at different ratios, we were able to increase the percentage of lymphocytes with bound platelets. The coculture of platelets with lymphocytes in the presence of stimulation decreased the production of IFN-γ and TNF-α, T cell proliferation, and the expression of CD25, PD-L1, and SLAM...
March 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28250131/measles-virus-enters-breast-and-colon-cancer-cell-lines-through-a-pvrl4-mediated-macropinocytosis-pathway
#18
Sebastien Delpeut, Gary Sisson, Karen M Black, Christopher D Richardson
Measles virus (MeV) is a member of the family Paramixoviridae that causes a highly contagious respiratory disease, but has emerged as a promising oncolytic platform. Previous studies of MeV entry have focused on the identification of cellular receptors. However, the endocytic and trafficking pathways utilized during MeV entry remain poorly described. The contribution of each endocytic pathway has been examined in cells that express MeV receptors, SLAM (Signaling Lymphocyte-Activating Molecule) and PVRL4 (Poliovirus Receptor-Like-4, nectin-4)...
March 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28208766/improved-omnidirectional-odometry-for-a-view-based-mapping-approach
#19
David Valiente, Arturo Gil, Óscar Reinoso, Miguel Juliá, Mathew Holloway
This work presents an improved visual odometry using omnidirectional images. The main purpose is to generate a reliable prior input which enhances the SLAM (Simultaneous Localization and Mapping) estimation tasks within the framework of navigation in mobile robotics, in detriment of the internal odometry data. Generally, standard SLAM approaches extensively use data such as the main prior input to localize the robot. They also tend to consider sensory data acquired with GPSs, lasers or digital cameras, as the more commonly acknowledged to re-estimate the solution...
February 9, 2017: Sensors
https://www.readbyqxmd.com/read/28167480/effect-of-total-flavonoids-of-scutellaria-barbata-on-cognitive-function-and-nogo-a-expression-in-the-hippocampus-in-cerebral-ischemia-model-in-gerbils
#20
Yanping Zhang, Yanmei Li
To explore the effect of total flavonoids of Scutellaria barbata on cognitive function and nogo-A expression in the hippocampus region in cerebral ischemia model in gerbils. 30 gerbils were randomly divided into model group, sham operation group, large dose of total flavonoids of Scutellaria barbata group (large dose group), middle dose of total flavonoids of Scutellaria barbata group (middle dose group) and small dose of total flavonoids of Scutellaria barbata group (small dose group), with 6 cases in each group...
November 2016: Pakistan Journal of Pharmaceutical Sciences
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