keyword
MENU ▼
Read by QxMD icon Read
search

Dengvaxia

keyword
https://www.readbyqxmd.com/read/30309284/vaccine-confidence-plummets-in-the-philippines-following-dengue-vaccine-scare-why-it-matters-to-pandemic-preparedness
#1
Heidi J Larson, Kenneth Hartigan-Go, Alexandre de Figueiredo
In November 2017, it was announced that the new dengue vaccine ("Dengvaxia") had risks for those not previously exposed to dengue. While some countries proceeded with adjusting guidance accordingly, the Philippines reacted with outrage and political turmoil with naming and shaming of government officials involved in purchasing the vaccine, as well as scientists involved in the vaccine trials and assessment. The result was broken public trust around the dengue vaccine as well heightened anxiety around vaccines in general...
October 12, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30213255/dengue-a-growing-threat-requiring-vaccine-development-for-disease-prevention
#2
Sandra Bos, Gilles Gadea, Philippe Despres
Dengue disease is the most prevalent mosquito-borne viral infection in humans. At least one half of the global population is estimated at risk of infection and an estimated 390 million people are infected each year. Over the past few years, dengue burden continued to increase, mainly impacting developing countries. Alarming changes in dengue epidemiology were observed highlighting a spread from tropical to subtropical regions as well as urban to rural areas. An increase in the co-infections with the four serotypes has also been noticed, involving a shift in the targeted population from pediatric to adult...
September 14, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/30190720/recent-developments-in-recombinant-protein-based-dengue-vaccines
#3
REVIEW
Nagesh K Tripathi, Ambuj Shrivastava
Recombinant proteins are gaining enormous importance these days due to their wide application as biopharmaceutical products and proven safety record. Various recombinant proteins of therapeutic and prophylactic importance have been successfully produced in microbial and higher expression host systems. Since there is no specific antiviral therapy available against dengue, the prevention by vaccination is the mainstay in reducing the disease burden. Therefore, efficacious vaccines are needed to control the spread of dengue worldwide...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30185598/potent-neutralizing-human-monoclonal-antibodies-preferentially-target-mature-dengue-virus-particles-implication-for-novel-strategy-of-dengue-vaccine
#4
Wen-Yang Tsai, Hui-Ling Chen, Jih-Jin Tsai, Wanwisa Dejnirattisai, Amonrat Jumnainsong, Juthathip Mongkolsapaya, Gavin Screaton, James E Crowe, Wei-Kung Wang
The four serotypes of dengue virus (DENV) cause the most important mosquito-borne viral disease in humans. The envelope (E) protein is the major target of neutralizing antibodies and contains 3 domains (DI, DII and DIII). Recent studies reported that human monoclonal antibodies (mAbs) recognizing the DIII, D1/DII hinge, the E-dimer epitope or a quaternary epitope involving DI/DII/DIII are more potently neutralizing compared with those recognizing the fusion-loop (FL) of DII. Due to inefficient cleavage of premembrane protein, DENV suspensions consist of a mixture of mature, immature and partially immature particles...
September 5, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30153226/vaccine-demand-and-willingness-to-pay-for-arbovirus-vaccines-a-cross-sectional-survey-in-rural-guatemala
#5
Daniel Olson, Anne-Marie Rick, Steven Krager, Molly Lamb, Edwin J Asturias
BACKGROUND: Arboviruses including dengue (DENV), chikungunya (CHIKV) and Zika cause significant morbidity in Latin America. With multiple arbovirus vaccines in development, better understanding of community attitudes and acceptability for these vaccines is needed. METHODS: In September 2016, a cross-sectional survey assessed arbovirus knowledge, attitudes, vaccine demand and willingness-to-pay (WTP) at the conclusion of a DENV/norovirus surveillance study in rural Guatemala with high arbovirus endemicity...
November 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/30027735/discovery-of-immunologically-inspired-small-molecules-that-target-the-viral-envelope-protein
#6
Wenlong Lian, Jaebong Jang, Supanee Potisopon, Pi-Chun Li, Amal Rahmeh, Jinhua Wang, Nicholas P Kwiatkowski, Nathanael S Gray, Priscilla L Yang
Dengue virus is a major human pathogen that infects over 390 million people annually leading to approximately 500 000 hospitalizations due to severe dengue. Since the only marketed vaccine, Dengvaxia, has recently been shown to increase disease severity in those lacking natural immunity, antivirals to prevent or treat dengue  infection represent a large, unmet medical need. Small molecules that target the dengue virus envelope protein, E, on the surface of the virion could act analogously to antibodies by engaging E extracellularly to block infection; however, a shortage of target-based assays suitable for screening and medicinal chemistry studies has limited efforts in this area...
September 14, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/30025788/mathematical-assessment-of-the-role-of-dengvaxia-vaccine-on-the-transmission-dynamics-of-dengue-serotypes
#7
Enahoro A Iboi, Abba B Gumel
A new mathematical model is designed and used to assess the impact of the newly-released Dengvaxia vaccine on the transmission dynamics of two co-circulating dengue strains (where strain 1 consists of dengue serotypes 1, 3 and 4; and strain 2 consists of dengue serotype 2). It is shown that the model exhibits the phenomenon of backward bifurcation when the disease-induced mortality in the host population exceeds a certain threshold value or if the vaccine does not provide perfect protection against infection with the two strains...
October 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/30016491/implementing-a-dengue-vaccination-programme-who-where-and-how
#8
Hannah E Clapham, Bridget A Wills
The complex interaction between dengue viruses and the human immune system means that development of a safe, effective dengue vaccine was never going to be simple. The only currently licenced dengue vaccine (Dengvaxia®) does, indeed, have a complex immune profile depending on recipients' immune status, meaning that use of this vaccine is not straightforward. This commentary reviews the recommendations for vaccine use to date, and discusses issues and opportunities related to the implementation of vaccination programmes in light of these recommendations...
August 1, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29982700/projected-costs-associated-with-school-based-screening-to-inform-deployment-of-dengvaxia-vietnam-as-a-case-study
#9
Hugo C Turner, Bridget A Wills, Motiur Rahman, Hoang Quoc Cuong, Guy E Thwaites, Maciej F Boni, Hannah E Clapham
Background: After new analysis, Sanofi Pasteur now recommends their dengue vaccine (Dengvaxia) should only be given to individuals previously infected with dengue and the World Health Organization's recommendations regarding its use are currently being revised. As a result, the potential costs of performing large-scale individual dengue screening and/or dengue serosurveys have become an important consideration for decision making by policymakers in dengue-endemic areas. Methods: We used an ingredients-based approach to estimate the financial costs for conducting both a school-based dengue serosurvey and school-based individual dengue screening within a typical province in Vietnam, using an existing commercial indirect immunoglobulin G enzyme-linked immunosorbent assay kit...
August 1, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29701995/optimization-of-surface-display-of-denv2-e-protein-on-a-nanoparticle-to-induce-virus-specific-neutralizing-antibody-responses
#10
Jason E Coffman, Stefan W Metz, Alex Brackbill, Molly Paul, Michael J Miley, Joseph DeSimone, J Christopher Luft, Aravinda de Silva, Shaomin Tian
The dengue virus (DENV) causes over 350 million infections, resulting in ∼25,000 deaths per year globally. An effective dengue vaccine requires generation of strong and balanced neutralizing antibodies against all four antigenically distinct serotypes of DENV. The leading live-attenuated tetravalent dengue virus vaccine platform has shown partial efficacy, with an unbalanced response across the four serotypes in clinical trials. DENV subunit vaccine platforms are being developed because they provide a strong safety profile and are expected to avoid the unbalanced immunization issues associated with live multivalent vaccines...
May 16, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29573874/a-multi-country-study-of-dengue-vaccination-strategies-with-dengvaxia-and-a-future-vaccine-candidate-in-three-dengue-endemic-countries-vietnam-thailand-and-colombia
#11
MULTICENTER STUDY
Jung-Seok Lee, José Lourenço, Sunetra Gupta, Andrew Farlow
BACKGROUND: The dengue vaccination era began when Dengvaxia (CYD-TDV) became available in 2016. In addition, several second-generation vaccine candidates are currently in phase 3 trials, suggesting that a broader availability of dengue vaccines may be possible in the near future. Advancing on the recent WHO-SAGE recommendations for the safe and effective use of CYD-TDV at the regional level on average, this study investigates the vaccination impacts and cost-effectiveness of CYD-TDV and of a hypothetical new vaccine candidate (NVC) in a country-specific manner for three endemic countries: Vietnam, Thailand, and Colombia...
April 19, 2018: Vaccine
https://www.readbyqxmd.com/read/29520688/experimental-in-vitro-and-in-vivo-systems-for-studying-the-innate-immune-response-during-dengue-virus-infections
#12
REVIEW
Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara
Dengue is the most prevalent arboviral disease in humans and leads to significant morbidity and socioeconomic burden in tropical and subtropical areas. Dengue is caused by infection with any of the four closely related serotypes of dengue virus (DENV1-4) and usually manifests as a mild febrile illness, but may develop into fatal dengue hemorrhagic fever and shock syndrome. There are no specific antiviral therapies against dengue because understanding of DENV biology is limited. A tetravalent chimeric dengue vaccine, Dengvaxia, has finally been licensed for use, but its efficacy was significantly lower against DENV-2 infections and in dengue-naïve individuals...
July 2018: Archives of Virology
https://www.readbyqxmd.com/read/29491253/dengue-virus-and-its-inhibitors-a-brief-review
#13
REVIEW
Yu-Shi Tian, Yi Zhou, Tatsuya Takagi, Masanori Kameoka, Norihito Kawashita
The global occurrence of viral infectious diseases poses a significant threat to human health. Dengue virus (DENV) infection is one of the most noteworthy of these infections. According to a WHO survey, approximately 400 million people are infected annually; symptoms deteriorate in approximately one percent of cases. Numerous foundational and clinical investigations on viral epidemiology, structure and function analysis, infection source and route, therapeutic targets, vaccines, and therapeutic drugs have been conducted by both academic and industrial researchers...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29482433/safety-issues-from-a-phase-3-clinical-trial-of-a-live-attenuated-chimeric-yellow-fever-tetravalent-dengue-vaccine
#14
Scott B Halstead
A tetravalent live-attenuated 3-dose vaccine composed of chimeras of yellow fever 17D and the four dengue viruses (CYD, also called Dengvaxia) completed phase 3 clinical testing in over 35,000 children leading to a recommendation that vaccine be administered to >/ = 9 year-olds residing in highly dengue- endemic countries. When clinical trial results were assessed 2 years after the first dose, vaccine efficacy among seropositives was high, but among seronegatives efficacy was marginal. Breakthrough dengue hospitalizations of vaccinated children occurred continuously over a period of 4-5 years post 3rd dose in an age distribution suggesting these children had been vaccinated when seronegative...
2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29404200/comparative-proteomics-reveals-that-yk51-a-4-hydroxypandurantin-a-analogue-downregulates-the-expression-of-proteins-associated-with-dengue-virus-infection
#15
Wei-Lian Tan, Yean Kee Lee, Yen Fong Ho, Rohana Yusof, Noorsaadah Abdul Rahman, Saiful Anuar Karsani
Dengue is endemic throughout tropical and subtropical regions of the world. Currently, there is no clinically approved therapeutic drug available for this acute viral infection. Although the first dengue vaccine Dengvaxia has been approved for use in certain countries, it is limited to those without a previous dengue infection while the safety and efficacy of the vaccine in those elderly and younger children still need to be identified. Therefore, it is becoming increasingly important to develop therapeutics/drugs to combat dengue virus (DENV) infection...
2018: PeerJ
https://www.readbyqxmd.com/read/29360072/-dengue-zika-chikungunya-and-the-development-of-vaccines
#16
Isabel N Kantor
Dengue (DENV), zika (ZIKV) and chikungunya (CHIKV), three arbovirosis transmitted by Aedes mosquitoes, have spread in recent decades in humid tropical and subtropical zones. Dengue is epidemic in subtropical areas of Argentina. DENV infection confers lasting immunity against the infecting serotype but increases the risk of serious disease upon reinfection by any of the other three. The recombinant tetravalent vaccine Dengvaxia® prevents severe dengue and hospitalization in seropositive subjects. In 2017, Dengvaxia was approved in Argentina, for ages 9 to 45, but is not included in the national vaccination calendar...
2018: Medicina
https://www.readbyqxmd.com/read/29300876/impact-of-dengue-vaccination-on-serological-diagnosis-insights-from-phase-iii-dengue-vaccine-efficacy-trials
#17
Eric Plennevaux, Annick Moureau, José L Arredondo-García, Luis Villar, Punnee Pitisuttithum, Ngoc H Tran, Matthew Bonaparte, Danaya Chansinghakul, Diana L Coronel, Maïna L'Azou, R Leon Ochiai, Myew-Ling Toh, Fernando Noriega, Alain Bouckenooghe
Background: We previously reported that vaccination with the tetravalent dengue vaccine (CYD-TDV; Dengvaxia) may bias the diagnosis of dengue based on immunoglobulin M (IgM) and immunoglobulin G (IgG) assessments. Methods: We undertook a post hoc pooled analysis of febrile episodes that occurred during the active surveillance phase (the 25 months after the first study injection) of 2 pivotal phase III, placebo-controlled CYD-TDV efficacy studies that involved ≥31000 children aged 2-16 years across 10 countries in Asia and Latin America...
April 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29180056/controversy-and-debate-on-dengue-vaccine-series-paper-1-review-of-a-licensed-dengue-vaccine-inappropriate-subgroup-analyses-and-selective-reporting-may-cause-harm-in-mass-vaccination-programs
#18
Antonio L Dans, Leonila F Dans, Mary Ann D Lansang, Maria Asuncion A Silvestre, Gordon H Guyatt
Severe life-threatening dengue fever usually occurs when a child is infected by dengue virus a second time. This is caused by a phenomenon called antibody-dependent enhancement (ADE). Since dengue vaccines can mimic a first infection in seronegative children (those with no previous infection), a natural infection later in life could lead to severe disease. The possibility that dengue vaccines can cause severe dengue through ADE has led to serious concern regarding the safety of mass vaccination programs. A published meta-analysis addressed this safety issue for a new vaccine against dengue fever-Dengvaxia...
March 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29088406/dengvaxia-efficacy-dependency-on-serostatus-a-closer-look-at-more-recent-data
#19
Maíra Aguiar, Nico Stollenwerk
No abstract text is available yet for this article.
February 1, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29029938/dengvaxia-sensitizes-seronegatives-to-vaccine-enhanced-disease-regardless-of-age
#20
Scott B Halstead
During a large scale clinical efficacy trial of the Sanofipasteur live-attenuated tetravalent dengue vaccine (Dengvaxia), features of hospitalized disease accompanying dengue infections in placebo recipients were closely similar to those in vaccinated children. However, the age specific hospitalization curves for these two populations differed. The curve for children vaccinated at ages 2-16 years closely resembled the 1981 age specific hospitalization rate curve for Cuban children infected with DENV 2 who were sensitized by a prior DENV 1 infection...
November 7, 2017: Vaccine
keyword
keyword
168229
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"