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Oocyte retrieval

Pinxiu Huang, Minling Tang, Aiping Qin
BACKGROUND: Poor ovarian response (POR) to ovarian hyperstimulation is one of the biggest challenges in assisted reproduction technology. The objective of this study was to compare the efficacy of progestin-primed ovarian stimulation (PPOS) with a GnRH antagonist (GnRH-ant) in poor ovarian response (POR) patients. MATERIALS AND METHODS: This retrospective analysis included a total of 186 cycles of POR patients between 2014 and 2016. The patients were divided into two groups according to the method of stimulation protocol, as follows: 63 cycles were PPOS, and 123 cycles were GnRH-ant...
October 12, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Pietro Bortoletto, Malavika Prabhu, Elizabeth M Garry, Krista F Huybrechts, Raymond M Anchan, Brian T Bateman
OBJECTIVE: To study opioid dispensing patterns following oocyte retrieval. DESIGN: Retrospective cohort. SETTING: Not applicable. PATIENT(S): Women undergoing oocyte retrieval with a maximum of 1 opioid prescription in the 12 weeks prior to the procedure, without an opioid use or other substance use disorder. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): We measured the frequency of opioids dispensed within 3 days of oocyte retrieval, most common opioids dispensed; and quantity dispensed, in median (interquartile range [IQR] and 10th-90th percentile ranges) oral morphine milligram equivalents (MME)...
October 2018: Fertility and Sterility
Shelby A Neal, Scott J Morin, Jason M Franasiak, Linnea R Goodman, Caroline R Juneau, Eric J Forman, Marie D Werner, Richard T Scott
OBJECTIVE: To determine if preimplantation genetic testing for aneuploidy (PGT-A) is cost-effective for patients undergoing in vitro fertilization (IVF). DESIGN: Decision analytic model comparing costs and clinical outcomes of two strategies: IVF with and without PGT-A. SETTING: Genetics laboratory. PATIENTS: Women ≤ 42 years of age undergoing IVF. INTERVENTION(S): Decision analytic model applied to the above patient population utilizing a combination of actual clinical data and assumptions from the literature regarding the outcomes of IVF with and without PGT-A...
October 2018: Fertility and Sterility
Tricia E Wright
No abstract text is available yet for this article.
October 2018: Fertility and Sterility
Beatrice Chung Fat King Brunet, Jiandong Shen, Lingbo Cai, Jiazhi Xie, Yugui Cui, Jiayin Liu, Wei Wu
RESEARCH QUESTION: Can preimplantation genetic testing (PGT) with next-generation sequencing (NGS) increase the chance of achieving a balanced euploid pregnancy in complex chromosome rearrangement (CCR) carriers? DESIGN: Six couples underwent PGT at the Clinical Centre of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University. The CCR carriers in the six couples were: Case A: 46,XY,t(1;4;11)(p31;p16;q22); Case B: 46,XY,t(3;13;5)(p14;q21;p14); Case C: 46,XX,t(6;11;21)(q21;q21;q13); Case D: 46,XX,inv(9)(p12; q13),t(13;15)(q14;q24); Case E: 46,XX,inv(9)(p12;q13),t(7;9)(q22;p22); and Case F: 46,XX,t(2;7)(q21;q36),t(2;4)(p10;q10),t(2;4)(q15;q10)...
September 2018: Reproductive Biomedicine Online
Georg Griesinger, Christophe Blockeel, Gennady T Sukhikh, Ameet Patki, Bharati Dhorepatil, Dong-Zi Yang, Zi-Jiang Chen, Elke Kahler, Claire Pexman-Fieth, Herman Tournaye
STUDY QUESTION: Is oral dydrogesterone 30 mg daily non-inferior to 8% micronized vaginal progesterone (MVP) gel 90 mg daily for luteal phase support in IVF? SUMMARY ANSWER: Oral dydrogesterone demonstrated non-inferiority to MVP gel for the presence of fetal heartbeats at 12 weeks of gestation (non-inferiority margin 10%). WHAT IS KNOWN ALREADY: The standard of care for luteal phase support in IVF is the use of MVP; however, it is associated with vaginal irritation, discharge and poor patient compliance...
October 10, 2018: Human Reproduction
Zhihui Xu, Lvhe Meng, Chengshuang Pan, Xia Chen, Xuefeng Huang, Haiyan Yang
This study aims to investigate whether oral contraceptive pills (OCP) pretreatment impairs pregnancy outcomes in polycystic ovary syndrome (PCOS) women undergoing GnRH agonist protocol. A total of 1025 couples underwent their first cycle of in vitro fertilization. Patients were divided into GnRH agonist protocol group (LP group) and OCP dual suppression GnRH agonist protocol group (OC-LP group). Logistic regressions were performed to estimate the risk factors affecting live birth following fresh embryo transfer between groups...
October 10, 2018: Gynecological Endocrinology
Hui Long, Yanhong Nie, Li Wang, Yong Lu, Yan Wang, Yijun Cai, Zhen Liu, Miaomiao Jia, Qifeng Lyu, Yanping Qifeng, Qiang Sun
AMH as a promising predictor of ovarian response has been studied extensively in women undergoing assisted reproductive technology treatment, but little is known about its prediction value in monkeys undergoing ovarian stimulation. In the current study, a total of 380 cynomolgus monkeys ranging from 5 to 12 years received 699 ovarian stimulation cycles. Serum samples were collected for AMH measure with enzyme-linked immunosorbent assay. It was found that serum AMH levels were positive correlated with the number of retrieved oocytes (P < 0...
September 1, 2018: Endocrine Connections
Lindsay Merlotti, Wendy Kuohung, John Rinehart
PURPOSE OF REVIEW: Determine if literature supports the use of anti-Müllerian hormone (AMH) as a useful biomarker of reproductive potential when cumulative live birth rates (CLBRs) per retrieval are used as the outcome variable. RECENT FINDINGS: Advances in technology used in in-vitro fertilization (IVF) permit the use of single embryo transfer to achieve expected pregnancy success rates. Many IVF cycles result in the creation of more than a single embryo suitable for transfer per oocyte retrieval...
October 6, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
J Chen, H J Yuan, Y Q Cui, W Yan, H Y Lian, X Y Liu, W Zhang, X M Liu, C F Hao, X Wang
Objective: To evalute the clinical outcomes of intracytoplasmic sperm injection(ICSI) for infertility male with severe asthenospermia induced by multiple morphological anomalies of the flagella (MMAF). Methods: The clinical data of 15 patient with MMAF were retrospectively analyzed, who underwent ICSI treatment using hyponotic swelling test the "live" sperm in the Department of Reproductive Medicine of Yantai Yuhuangding Hospital from January 2011 to December 2016. Another 30 obstructive azoospermia (OA)patients are matched strictly who also accepted ICSI in the same treatment time...
September 25, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Shang Li, Junyu Zhai, Jiansheng Liu, Fangfang Di, Yun Sun, Weiping Li, Zi-Jiang Chen, Yanzhi Du
BACKGROUND: The ovulatory dysfunction mechanisms underlying polycystic ovary syndrome (PCOS) are not completely understood. And the roles of EPHA7 and EPHA7-regulated pathway factors in the pathogenesis of anovulation remain to be elucidated. METHODS: We used human granulosa cells (hGCs) of PCOS and non-PCOS patients to measure EPHA7 and other target gene expressions. We performed in vitro experiments in KGN cells to verify the molecular mechanisms. Additionally, we conducted in vivo loss- and gain-of-function studies using EPHA7 shRNA lentivirus and recombinant EPHA7-Fc protein injection to identify the ovulation effects of EPHA7...
October 3, 2018: EBioMedicine
Fatemeh Hassani, Shahrbanoo Oryan, Poopak Eftekhari-Yazdi, Masood Bazrgar, Ashraf Moini, Nahid Nasiri, Azadeh Ghaheri
Background: The objective of this study was to describe the association between luteinizing hormone (LH)/ follicle-stimulating hormone (FSH) ratio and demographic variables and maturation stage of oocytes in insulinresistant and insulin-sensitive patients with polycystic ovary syndrome (PCOS) in comparison with control group. Materials and Methods: In this case-control study, 60 patients with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) indication were subdivided into 3 groups as follow: 20 subjects were assigned to control (fertile women with male infertility history) group, 20 subjects with PCOS were insulin resistant (IR) and 20 subjects with PCOS were insulin sensitive (IS)...
January 2019: International Journal of Fertility & Sterility
Arie Berkovitz, Netanella Miller, Michal Silberman, Michael Belenky, Pavel Itsykson
STUDY QUESTION: Does a novel sperm vitrification device (SpermVD) provide an efficient method for freezing a small number of human spermatozoa from men suffering from non-obstructive azoospermia? SUMMARY ANSWER: The novel SpermVD is an efficient and simple carrier method for freezing a small number of spermatozoa in low-volume droplets, reducing post-thaw search time from hours to minutes, allowing a 96% recovery rate and leading to successful use of sperm for fertilization...
October 4, 2018: Human Reproduction
Pei-Yi Wang, Yi-En Chang, Yu-Chieh Lee, Chii Ruey Tzeng
Objective: To obtain a better understanding of the clinical course and the subsequent complications of teratoma rupture. Case: We report a rare case of chemical peritonitis and pleuritis caused by teratoma rupture during ultrasonographically guided transvaginal oocyte retrieval (TVOR). The patient initially presented with nonspecific and digestive symptoms after TVOR, but the condition deteriorated rapidly after three weeks with peritonitis and septic shock. Thus, exploratory laparoscopy was performed with the findings of a ruptured teratoma at left adnexa, severe adhesions, and purulent fluid in her peritoneal cavity...
2018: Case Reports in Obstetrics and Gynecology
Marta Devesa, Rosa Tur, Ignacio Rodríguez, Buenaventura Coroleu, Francisca Martínez, Nikolaos P Polyzos
STUDY QUESTION: Is there any relationship between the number of oocytes retrieved and cumulative live birth rates (CLBRs) in women of advanced age? SUMMARY ANSWER: CLBRs increase with the number of oocytes retrieved in women of advanced reproductive age up to 41 years old, the added value is minimal in women more than 41 years and futile in women 44 years or older. WHAT IS KNOWN ALREADY: CLBR is actually the most relevant outcome of IVF from patients' perspective...
September 29, 2018: Human Reproduction
Chuyue Zhang, Jin Ma, Wangsheng Wang, Yun Sun, Kang Sun
STUDY QUESTION: Is overexpression of lysyl oxidase (LOX), an enzyme responsible for the cross-linking of collagens, a cause of anovulation in polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: LOX overexpression was present in PCOS ovaries, due at least in part to interleukin-1β (IL-1β), and inhibition of LOX activity with β-aminopropionitrile (BAPN) ameliorated polycystic ovary morphology and anovulation. WHAT IS KNOWN ALREADY: Aberrant ovarian extracellular matrix (ECM) remodeling and inflammation may contribute to the development of PCOS...
September 29, 2018: Human Reproduction
Yang Yu, Qi Xi, Yuan Pan, Yuting Jiang, Hongguo Zhang, Linlin Li, Ruizhi Liu
BACKGROUND The safety of intracytoplasmic sperm injection (ICSI) with testicular sperm in azoospermic men has been a concern. We evaluated ICSI outcomes, including neonatal outcomes, in children born using testicular sperm or donor sperm. MATERIAL AND METHODS Ninety-nine males with nonobstructive azoospermia (NOA) who underwent microdissection testicular sperm extraction (micro-TESE) and 126 males with obstructive azoospermia (OA) were included in this study. Sixty-one patients with NOA used donor sperm for ICSI on the day of oocyte retrieval when no spermatozoa were identified by micro-TESE on the day before oocyte retrieval...
October 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Danilo Cimadomo, Antonio Capalbo, Paolo Emanuele Levi-Setti, Daria Soscia, Giovanna Orlando, Elena Albani, Valentina Parini, Marta Stoppa, Lisa Dovere, Luisa Tacconi, Elena Ievoli, Roberta Maggiulli, Filippo Maria Ubaldi, Laura Rienzi
STUDY QUESTION: Are trophectoderm biopsy or other pre-vitrification features or laboratory practices associated with differences in blastocyst post-warming behavior (degeneration, re-expansion and live birth after single embryo transfer (SET))? SUMMARY ANSWER: Blastocyst morphology, day of full development and artificial shrinkage (either laser-assisted or biopsy-induced) are the pre-vitrification parameters/practices most strongly associated with post-warming behavior and implantation potential while there was no association with trophectoderm biopsy...
September 28, 2018: Human Reproduction
Ana Paula Cb Campos, Guilherme P Geber, Rodrigo Hurtado, Marcos Sampaio, Selmo Geber
OBJECTIVE: To evaluate COS and oocyte retrieval results in ART treatment cycles initiated at any stage of the menstrual cycle (random start) in cancer patients, who could not postpone the onset of cancer treatment. METHODS: Prospective observational study of 26 women with cancer, with an indication to start cancer treatment within the next 20 days and wishing to preserve their fertility. Ovarian stimulation started immediately with FSH followed by GnRH antagonist for pituitary suppression and GnRH agonist for oocyte maturation...
September 28, 2018: JBRA Assisted Reproduction
S F Lai, R Hw Li, W Sb Yeung, E Hy Ng
OBJECTIVE: To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment. METHODS: We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong. RESULTS: We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P<0...
October 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
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