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Patch augmentation

Lili Hou, Min Zhang, Xingyi Zhang, Zhenwei Liu, Pengyu Zhang, Dongying Qiu, Lei Zhu, Xin Zhou
The airway vagal preganglionic neurons (AVPNs) providing projections to intrinsic tracheobronchial ganglia are considered to be crucial to modulation of airway resistance in physiological and pathological states. AVPNs classified into inspiratory-activated AVPNs (IA-AVPNs) and inspiratory-inhibited AVPNs (II-AVPNs) are regulated by thyrotropin-releasing hormone (TRH)-containing terminals. TRH causes a direct excitatory current and attenuates the phasic inspiratory glycinergic inputs in II-AVPNs, however, whether and how TRH influences IA-AVPNs remains unknown...
2018: Frontiers in Physiology
Roni M Jacobsen, Michael E Mitchell, Ronald K Woods, Rohit S Loomba, James S Tweddell
BACKGROUND: Norwood palliation typically requires patch augmentation of the ascending aorta and aortic arch. Patients having undergone Norwood palliation are at risk of recurrent arch obstruction, the risk of which may be impacted by the type of patch material used at the time of Norwood palliation. We sought to determine the freedom from neo-aortic arch re-intervention and overall survival in patients who underwent Norwood palliation utilizing porcine small intestinal submucosa (PSIS) as the patch material...
July 25, 2018: Annals of Thoracic Surgery
Kevin D He, George N Rymarczuk, Shannon W Clark, John L Gillick, Payman Vahedi, Ashwini D Sharan
BACKGROUND: Subarachnoid-pleural fistulas (SPFs) are rare but significant complications of transthoracic spinal surgery. Whether noted intraoperatively or in the postoperative period, SPF requires implementation of aggressive management, with consideration given to direct surgical repair. Additionally, the physical constraints of the thoracic cavity often hinder direct SPF repair. OBJECTIVE: To present a novel operative technique that can be used to easily and quickly address incidental durotomy incurred during transthoracic spinal surgery while working within the confines of the thorax...
July 21, 2018: Operative Neurosurgery (Hagerstown, Md.)
E Carlos Rodriguez-Merchan
INTRODUCTION: Tobacco use is related to augmented morbidity and mortality. People who smoke heavily before orthopaedic surgery may have more non-medical complications than non-smokers. Therefore, all orthopedic surgery patients should be screened for tobacco use. AIM: To investigate the musculoskeletal effects of peri-operative smoking. METHODS: A narrative review of the literature on the topic was performed. RESULTS: Orthopaedic peri-operative complications of smoking include impaired wound healing, augmented infection, delayed and/or impaired fracture union and arthrodesis, and worst total knee and hip arthroplasty results...
July 27, 2018: Hospital Practice (Minneapolis)
Hisayuki Hongu, Masaaki Yamagishi, Takako Miyazaki, Yoshinobu Maeda, Satoshi Taniguchi, Satoshi Asada, Shuhei Fujita, Hitoshi Yaku
BACKGROUND: Conventional Rastelli, Lecompte, and Nikaidoh operations are accepted as standard techniques for complete transposition of the great arteries (TGA) with left ventricular outflow tract (LVOT) obstruction. However, these operations show serious drawbacks, including postoperative obstruction of both ventricular outflow tracts. We developed the half-turned truncal switch operation (HTTSO) to address these problems. METHODS: Between 2002 and 2017, 14 patients underwent HTTSO...
July 19, 2018: Annals of Thoracic Surgery
Zeinab A Ibrahim, Ghada F Hassan, Hoda Y Elgendy, Hanan A Al-Shenawy
BACKGROUND: Vitiligo is a common pigmentary disorder affecting about 1% of the general population. There are numerous medical and surgical treatments. Microneedling is an evolving treatment technique for an expanding number of dermatologic conditions. It is used also to augment transdermal drug delivery through pores created in the stratum corneum. AIM: To evaluate the efficacy of microneedling with tacrolimus versus its efficacy with calcipotriol plus betamethasone in vitiligo treatment...
July 16, 2018: Journal of Cosmetic Dermatology
Brandon K Zimmerman, Gerard A Ateshian
This study formulates a finite element algorithm for frictional contact of solid materials, accommodating finite deformation and sliding. The algorithm uses a penalty method regularized with an augmented Lagrangian scheme to enforce contact constraints in a nonmortar surface-to-surface approach. Use of a novel kinematical approach to contact detection and enforcement of frictional constraints allows solution of complex problems previously requiring mortar methods or contact smoothing algorithms. Patch tests are satisfied to a high degree of accuracy with a single-pass penalty method, ensuring formulation errors do not affect the solution...
August 1, 2018: Journal of Biomechanical Engineering
Aurelien Bustin, Damien Voilliot, Anne Menini, Jacques Felblinger, Christian de Chillou, Darius Burschka, Laurent Bonnemains, Freddy Odille
Isotropic three-dimensional (3D) acquisition is a challenging task in magnetic resonance imaging (MRI). Particularly in cardiac MRI, due to hardware and time limitations, current 3D acquisitions are limited by low-resolution, especially in the through-plane direction, leading to poor image quality in that dimension. To overcome this problem, super-resolution (SR) techniques have been proposed to reconstruct a single isotropic 3D volume from multiple anisotropic acquisitions. Previously, local regularization techniques such as total variation have been applied to limit noise amplification while preserving sharp edges and small features in the images...
August 2018: IEEE Transactions on Medical Imaging
Cédric Maillot, Edouard Harly, Hugues Demezon, Jean-Charles Le Huec
BACKGROUND: This prospective study compared the outcomes after 3 different treatments for large and massive rotator cuff tears. METHODS: Patients with a diagnosis of large-to-massive rotator cuff tears were prospectively included. Patients were allocated in 3 groups: (1) arthroscopic complete repair (repair group), (2) open repair and xenograft patch augmentation (patch group), and (3) arthroscopic débridement and tenotomy of the long head of the biceps (débridement group)...
July 3, 2018: Journal of Shoulder and Elbow Surgery
Arif Pendi, Jeffrey C Wang, Stacey Samuel Bederman, Saifal-Deen Farhan, Nitin N Bhatia, Yu-Po Lee, Jahanzeb Ashraf, Frank L Acosta
STUDY DESIGN: This was a cross-sectional study. OBJECTIVE: The objective of this study was to determine spine surgeons' preferences for the intraoperative and postoperative management of intraoperative durotomy (IDT) in decompression and spinal fusion surgeries. SUMMARY OF BACKGROUND DATA: Management guidelines for IDT remain elusive. Traditionally, management consists of intraoperative suturing and postoperative bed rest. However, preferences of North American spine surgeons may vary, particularly according to type of surgery...
June 29, 2018: Clinical Spine Surgery
Margaret Snyder, Jake E Turrentine, Ponciano D Cruz
Photo-contact dermatitis (PCD) describes the adverse cutaneous reaction that occurs in some patients as a result of simultaneous exposure to a contactant and to light. PCD can be subdivided into photo-allergic and photo-irritant dermatitis depending on whether the contactant respectively invokes an allergic or irritant reaction. Photo-irritant reactions are commonly caused by plants, psoralens, and medications taken internally, whereas photo-allergic reactions are commonly caused by sunscreens and topical nonsteroidal anti-inflammatory medications...
June 27, 2018: Clinical Reviews in Allergy & Immunology
Hiroyuki Kawai, Nozomi Asaoka, Takahito Miyake, Kazuki Nagayasu, Takayuki Nakagawa, Hisashi Shirakawa, Shuji Kaneko
Neurotropin (NTP) is a Japanese analgesic agent for treating neuropathic pain; however, its method of action remains unclear. This study examined the effects of NTP on the activity of small dorsal root ganglion (DRG) neurons using whole-cell patch clamp recordings. After 3 days of treatment, NTP decreased current injection-induced firing activity of cultured DRG neurons by raising the current threshold for action potential generation. Additionally, NTP increased the sustained component of voltage-gated potassium (Kv ) channel currents without affecting other K+ currents...
May 31, 2018: Journal of Pharmacological Sciences
Guo-Sheng Xiao, Yan-Hui Zhang, Yan Wang, Hai-Ying Sun, Clive M Baumgarten, Gui-Rong Li
BACKGROUND AND PURPOSE: Adrenergic regulation of cell volume-regulated chloride current (ICl.vol ) is species-dependent. The present study investigates the mechanism underlying adrenergic regulation of ICl.vol in human atrial myocytes. EXPERIMENTAL APPROACH: Conventional whole-cell patch voltage-clamp techniques were used to record membrane current in human atrial myocytes. ICl.vol was evoked by hyposmotic bath solution (0.6 times isosmotic, 0.6 T). KEY RESULTS: ICl...
June 13, 2018: British Journal of Pharmacology
Jaeyeon Yoon, Enhao Gong, Itthi Chatnuntawech, Berkin Bilgic, Jingu Lee, Woojin Jung, Jingyu Ko, Hosan Jung, Kawin Setsompop, Greg Zaharchuk, Eung Yeop Kim, John Pauly, Jongho Lee
Deep neural networks have demonstrated promising potential for the field of medical image reconstruction, successfully generating high quality images for CT, PET and MRI. In this work, an MRI reconstruction algorithm, which is referred to as quantitative susceptibility mapping (QSM), has been developed using a deep neural network in order to perform dipole deconvolution, which restores magnetic susceptibility source from an MRI field map. Previous approaches of QSM require multiple orientation data (e.g. Calculation of Susceptibility through Multiple Orientation Sampling or COSMOS) or regularization terms (e...
October 1, 2018: NeuroImage
Ying Liu, Ling Ye, Fang Lin, Yasmine Gomaa, David Flyer, Ricardo Carrion, Jean L Patterson, Mark R Prausnitz, Gale Smith, Gregory Glenn, Hua Wu, Richard W Compans, Chinglai Yang
In this study, we investigated immune responses induced by purified Ebola virus (EBOV) soluble glycoprotein (sGP) subunit vaccines via intradermal immunization with microneedle (MN) patches in comparison with intramuscular (IM) injection in mice. Our results showed that MN delivery of EBOV sGP was superior to IM injection in eliciting higher levels and longer lasting antibody responses against EBOV sGP and GP antigens. Moreover, sGP-specific immune responses induced by MN or IM immunizations were effectively augmented by formulating sGP with a saponin-based adjuvant, and they were shown to confer complete protection of mice against lethal mouse-adapted EBOV (MA-EBOV) challenge...
June 8, 2018: Journal of Infectious Diseases
Xuehang Zheng, Saiprasad Ravishankar, Yong Long, Jeffrey A Fessler
The development of computed tomography (CT) image reconstruction methods that significantly reduce patient radiation exposure, while maintaining high image quality is an important area of research in low-dose CT imaging. We propose a new penalized weighted least squares (PWLS) reconstruction method that exploits regularization based on an efficient Union of Learned TRAnsforms (PWLS-ULTRA). The union of square transforms is pre-learned from numerous image patches extracted from a dataset of CT images or volumes...
June 2018: IEEE Transactions on Medical Imaging
Sanjay R Kharche, Aaron So, Fabio Salerno, Ting-Yim Lee, Chris Ellis, Daniel Goldman, Christopher W McIntyre
Dialysis prolongs life but augments cardiovascular mortality. Imaging data suggests that dialysis increases myocardial blood flow (BF) heterogeneity, but its causes remain poorly understood. A biophysical model of human coronary vasculature was used to explain the imaging observations, and highlight causes of coronary BF heterogeneity. Post-dialysis CT images from patients under control, pharmacological stress (adenosine), therapy (cooled dialysate), and adenosine and cooled dialysate conditions were obtained...
2018: Frontiers in Physiology
Peter E Hammer, Christopher W Baird, Pedro J Del Nido, Gerald R Marx
No abstract text is available yet for this article.
May 3, 2018: Journal of Thoracic and Cardiovascular Surgery
Lei Qiu, Fengjie Liu, Shengguo Yi, Xueying Li, Xiaoqing Liu, Cheng Xiao, Christine Guo Lian, Ping Tu, Yang Wang
DNA hydroxymethylation at the 5 position of cytosine (5-hmC) is a product of the TET family of DNA hydroxylases. Accumulating evidence shows that loss of 5-hmC is critical for various biological and pathological processes. However, its level in cutaneous T-cell lymphoma (CTCL) remains largely unknown. Here, we report that the loss of 5-hmC is an epigenetic hallmark of CTCL, with diagnostic and prognostic implications. Immunohistochemistry staining on 90 mycosis fungoides (MF) samples showed a significant decrease of 5-hmC staining in CD4+ T cells in patch and tumor stages, especially in MF with large cell transformation, compared with benign inflammatory dermatoses...
May 24, 2018: Journal of Investigative Dermatology
Eilon Ram, Yaron Moshkovitz, Ami Shinfeld, Alexander Kogan, Alexander Lipey, Sagit Ben Zekry, Ronny Ben-Avi, Shany Levin, Ehud Raanani
BACKGROUND: To assess early and late clinical outcomes in patients who underwent aortic valve repair or aortic valve sparing surgery, and to investigate predictors for failure. METHODS: Of 227 consecutive patients who underwent aortic valve repair or sparing surgery in our department between 2004 and 2016, 81(36%) underwent aortic root replacement with or without cusp repair, 97(42%) ascending aorta replacement with or without cusp repair, and 49 (22%) isolated aortic valve repair...
May 22, 2018: Annals of Thoracic Surgery
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