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Ko Eun Kim, Pil Sung Yang, Eunsun Jang, Sungjin Kim, Boyoung Joung
PURPOSE: Antithrombotic therapy could be related with nuisance bleeding. This study investigated whether vitreous hemorrhage (VH) is associated with specific types of antithrombotic medication in patients with atrial fibrillation (AF). MATERIALS AND METHODS: In the Korean National Health Insurance Service National Sample Cohort, we identified 9352 antiplatelet/anticoagulant-treated AF patients. The occurrence of VH was compared between warfarin (n=1493) and a propensity score (PS)-matched antiplatelet group (n=1493) and between warfarin (n=1493) and a PS-matched warfarin+antiplatelet group (n=1493)...
January 2019: Yonsei Medical Journal
Gerrit Angst, Kevin E Mueller, David M Eissenstat, Susan Trumbore, Katherine H Freeman, Sarah E Hobbie, Jon Chorover, Jacek Oleksyn, Peter B Reich, Carsten W Mueller
Rising atmospheric CO2 concentrations have increased interest in the potential for forest ecosystems and soils to act as carbon (C) sinks. While soil organic C contents often vary with tree species identity, little is known about if, and how, tree species influence the stability of C in soil. Using a 40-year-old common garden experiment with replicated plots of eleven temperate tree species, we investigated relationships between soil organic matter (SOM) stability in mineral soils and 17 ecological factors (including tree tissue chemistry, magnitude of organic matter inputs and their turnover, microbial community descriptors, and soil physico-chemical properties)...
December 16, 2018: Global Change Biology
Davide Momi, Carmelo Smeralda, Giulia Sprugnoli, Francesco Neri, Simone Rossi, Alessandro Rossi, Giorgio Di Lorenzo, Emiliano Santarnecchi
Cross-sectional data suggest videogaming as promoting modifications in perceptual and cognitive skills of players, as well as inducing structural brain changes. However, whether such changes are both possible after a systematic gaming exposure, and last beyond the training period, is not known. Here we originally quantified immediate and long-lasting cognitive and morphometric impact of a systematic gaming experience on a first-person shooter (FPS) game. Thirty-five healthy participants, assigned to a videogaming and a control group, underwent a cognitive assessment including 14 tasks and structural magnetic resonance imaging at baseline (T0), post-gaming (T1) and at a three months' follow-up (T2)...
December 16, 2018: European Journal of Neuroscience
Jagdeep Singh Bhangu, Andreas Selberherr, Lindsay Brammen, Christian Scheuba, Philipp Riss
BACKGROUND: Twenty-four-hour renal calcium-excretion (CE) and calcium/creatinine-clearance-ratio (CCCR), respectively, are widely used to rule out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary hyperparathyroidism before surgery. The aim was to evaluate the practicability of CE compared to CCCR. PATIENTS AND METHODS: We analyzed biochemical parameters, surgical treatment, gene mutation results, and long-term follow-up data of 198 patients (including 14 patients with FHH) and the discriminative power of CE and CCCR...
December 15, 2018: Head & Neck
Amy R Monn, Na Zhang, Abigail H Gewirtz
This study examined the mediating role of posttraumatic stress disorder (PTSD) symptoms in the association between deployment-related trauma exposure and parenting behaviors in reserve-component military service members and whether this association was contingent upon parent inhibitory control (IC). Participants were 181 postdeployed fathers and their children. Fathers completed a neurospychological test of IC and self-report measures of trauma exposure and PTSD symptoms. Measures of parenting behaviors (positive engagement and reactivity coercion) were obtained from direct observation of father-child interaction...
December 2018: Journal of Traumatic Stress
Anthony J King, Anupa Shah, Eleni Nikita, Kuang Hu, Caroline A Mulvaney, Richard Stead, Augusto Azuara-Blanco
BACKGROUND: Glaucoma is a leading cause of irreversible blindness. Subconjunctival draining minimally-invasive glaucoma devices such as the Xen gelatin implant and InnFocus stent have been introduced as a treatment to prevent glaucoma progressing.These implants provide a channel to allow aqueous humour from the anterior chamber of the eye to drain into the subconjunctival space on the surface of the eye thus reducing intraocular pressure (IOP) and mimicking the mechanism of the most commonly undertaken glaucoma surgery, trabeculectomy...
December 16, 2018: Cochrane Database of Systematic Reviews
Valerio Gallotta, Alex Federico, Khaled Gaballa, Marco D'Indinosante, Carmine Conte, Maria Teresa Giudice, Angelica Naldini, Claudio Lodoli, Stefano Rotolo, Valeria Gallucci, Lucia Tortorella, Bruno Romanò, Giovanni Scambia, Gabriella Ferrandina
BACKGROUND AND OBJECTIVE: This study aims to investigate the surgical outcomes observed in robotic transperitoneal aortic lymphadenectomy (AL) in gynecological cancer patients. METHODS: Retrospective data were collected and analyzed on 71 patients undergoing robotic surgical procedures for gynecological cancers, including transperitoneal AL, between December 2014 and February 2018 at the Catholic University of the Sacred Heart, Rome, Italy. RESULTS: Median age of the sample population was 50 years (range, 26-76 years)...
December 16, 2018: Journal of Surgical Oncology
XiaoGang Shen, JiaRui Zhang, XiaoLong Zhang, YiFan Wang, YunFeng Hu, Jun Guo
Retinoic acid-induced 14 is a developmentally regulated gene induced by retinoic acid and is closely associated with NIK/NF-κB signaling. In the present study, we examined the effect of RAI14 on mTOR-mediated glial inflammation in response to inflammatory factors and chemical ischemia. A U87 cell model of LPS- and TNF-α-induced inflammation was used to investigate the role of RAI14 in glial inflammation. U87 cells were treated with siR-RAI14 or everolimus to detect the correlation between mTOR, RAI14, and NF-κB...
December 15, 2018: Cellular and Molecular Neurobiology
Itzamná Baqueiro-Peña, Ali Asaff-Torres, Manuel R Kirchmayr, Elisa M Valenzuela-Soto, Arturo Zamora
The aim of this research was to study the hydrolytic potential of bacteria isolated from cattle environments of two desert soils in one of the driest and hottest zones in America. A total of 26 points were sampled, 144 strains were isolated, and 50 strains were selected for the characterization of esterase, lipase, protease, and amylase activities and for 16S rRNA identification. Strains of the Bacillus, Pseudomonas, Acinetobacter, Enterobacter, Providencia, Escherichia, and Pantoea genera were identified. Comparisons of the proteolytic activity of the secretome from 14 strains (Bacillus n = 7, Escherichia n = 2; Providencia, Pseudomonas, Enterobacter, Pantoea and Acinetobacter n = 1) were performed...
December 15, 2018: World Journal of Microbiology & Biotechnology
Ki-Dong Sung, Elizabeth J Pekas, Steven D Scott, Won-Mok Son, Song-Young Park
INTRODUCTION: Childhood obesity is strongly associated with cardiovascular disease (CVD) development. It is necessary to combat unfavorable outcomes of obesity at a young age by utilizing effective interventions, such as exercise. PURPOSE: We sought to examine the effects of a jump rope exercise program on CVD risk factors, including body composition, vasoactive substances, inflammation, and vascular function in prehypertensive adolescent girls. METHODS: Forty girls (age 14-16) were recruited and randomly assigned to a jump rope exercise group (EX, n = 20) or control group (CON, n = 20)...
December 15, 2018: European Journal of Applied Physiology
Kingsley Wong, Helen Leonard, Glenn Pearson, Emma J Glasson, David Forbes, Madhur Ravikumara, Peter Jacoby, Jenny Bourke, Preeyaporn Srasuebkul, Julian Trollor, Andrew Wilson, Lakshmi Nagarajan, Jenny Downs
The largest group of recipients of pediatric gastrostomy have neurological impairment with intellectual disability (ID). This study investigated trends in first gastrostomy insertion according to markers of disadvantage and ID etiology. Linked administrative and health data collected over a 32-year study period (1983-2014) for children with ID born between 1983 and 2009 in Western Australia were examined. The annual incidence rate change over calendar year was calculated for all children and according to socioeconomic status, geographical remoteness, and Aboriginality...
December 15, 2018: European Journal of Pediatrics
Mohamed Z Sayed-Ahmed, Ahmed M Ahdy, Emad E Younis, Sabry A El-Khodery, Hany N Baraka
Dermatophytosis is a contagious fungal disease among animal communities. The major concerns of dermatophytosis are cost of treatment, difficulty of control, and the public health consequences. The objective of the present study was to compare the clinical efficacy of Sumaq and Neem extract cream with that of traditional treatments, eniloconazole and glycerine iodine, on dermatophytosis in Arabian horses. For this purpose, 37 Arabian horses with dermatophytosis had been used. Fungal isolation and identification for each horse were carried out by standard microbiological procedures...
December 15, 2018: Tropical Animal Health and Production
Huirong Ye, Xiumei Wu, Jiangzhi Yan, Jian Wang, Jianting Qiu, Yujie Wang
BACKGROUND: We investigated whether completeness of the circle of Willis (CoW) protected patients with severe internal carotid artery (ICA) stenosis against white matter hyperintensities (WMHs). METHODS: We included 115 patients with unilateral ICA stenosis ≥ 70%. The completeness of CoW was assessed and WMHs were rated on a visual scale. The score of deep and periventricular WMHs was compared between patients with complete and incomplete CoW and between the two hemispheres, ipsilateral and contralateral to stenosed ICA...
December 15, 2018: Neurological Sciences
Arnaud Wiedemann, Emeline Renard, Magali Hernandez, Brigitte Dousset, François Brezin, Laetitia Lambert, Georges Weryha, François Feillet
Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. We observed the effects of annual zoledronic acid (ZA) infusion in a cohort of children with cerebral palsy and Rett's syndrome. 27 children under 18 years (19 with cerebral palsy and 8 girls with Rett syndrome confirmed by MCEP2 mutation) were treated with an annual injection of 0...
December 15, 2018: Calcified Tissue International
Dongkuk Park, Jihoon Yun, Su-Jeong Hwang, Su Jin Park
INTRODUCTION: Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the financial burden of treatment. In the case of TNF-alpha inhibitors, they may also offer improved stability and enable prolonged use. SB5, an adalimumab biosimilar, has shown equivalent efficacy and comparable safety to its reference product in clinical trials...
December 15, 2018: Advances in Therapy
F F Laranjeira, T T C Santos, A S Moreira, I Sanches, A S Nascimento, S X B Silva, E C Andrade, D O Almeida
Diaphorina citri Kuwayama (Hemiptera: Liviidae), named as Asian citrus psyllid (ACP), is the vector of the bacterium associated with huanglongbing (HLB), the most destructive citrus disease. The use of citrus flushing and ACP monitoring tools is essential for the knowledge of the occurrence pattern of cycles of both and for the improvement of the ACP management. During 3 years, 20 branches from 20 trees were evaluated for vegetative flushing, ACP abundance, and occupation in tree and branches in a Brazilian citrus area free for HLB...
December 15, 2018: Neotropical Entomology
Jehuda Soleman, Andrea Bartoli, Akiva Korn, Shlomi Constantini, Jonathan Roth
The preferred treatment of patients with persistent, recurrent, or progressive syringomyelia after foramen magnum decompression (FMD) for Chiari I (CMI)-associated syringomyelia is controversial, and may include redo FMD, stabilization, or shunting procedures (such as syringopleural or syringo-subarachnoid shunts). We describe our experience in treating these patients and discuss the treatment modalities for these patients. We retrospectively collected data of CMI patients with persistent, recurrent, or progressive syringomyelia after FMD...
December 15, 2018: Neurosurgical Review
Labaz Beata, Kabala Cezary, Waroszewski Jaroslaw
The legal regulatory/action levels of trace elements in soils are established at high concentrations, at which the crucial functions of soil are at risk or are eliminated. However, concentrations below these action levels, but above presumed natural levels, may also limit particular ecosystem services, including organic food production. Thus, defining the (ambient) background concentrations is an essential part of environmental or health risk assessment, e.g., on Chernozems, which are considered to be the most productive soils and ones that should be protected against all forms of contamination...
December 15, 2018: Environmental Monitoring and Assessment
Jin Huang, Jun-Jie Hang, Xiang-Rong Qin, Jian Huang, Xiao-Yong Wang
BACKGROUND: Genetic polymorphisms of Toll-like receptors play important roles in gastric carcinogenesis. The aim of this study was to determine the role of TLR2-196 to -174 ins/del polymorphism in gastric cancer susceptibility and prognosis. METHODS: This study included 520 people from southern China. Samples were genotyped by the allele-specific polymerase chain reaction, among which 10% were randomly selected for sequencing. The serological method was used to determine Helicobacter pylori...
December 15, 2018: International Journal of Clinical Oncology
Victor Bouteleux, Laurent Kodjikian, Maud Mendes, Emilie Agard, Zaïnab Machkour-Bentaleb, Hussam El-Chehab, Philippe Denis, Thibaud Mathis, Corinne Dot
PURPOSE: The main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD). METHODS: A real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning...
December 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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