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https://www.readbyqxmd.com/read/30108392/role-of-melatonin-in-management-of-hypoxic-ischaemic-encephalopathy-in-newborns-a-randomized-control-trial
#1
Qazi Mumtaz Ahmad, Akmal Laeeq Chishti, Nayyab Waseem
OBJECTIVE: To find out the effect of melatonin as adjunct therapy on outcome of admitted newborns presenting with hypoxic ischaemic encephalopathy. METHODS: This randomized controlled trial was conducted at King Edward Medical University, Lahore, Pakistan, from October 2016 to March 2017, and comprised newborns with gestational age of 34 weeks or higher who fulfilled the definition of hypoxic ischaemic encephalopathy and presented within 12 hours of birth. The severity of hypoxic ischaemic encephalopathy was assessed by Thompson score...
August 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30038832/short-term-effects-of-trigger-point-dry-needling-on-pain-and-disability-in-subjects-with-patellofemoral-pain-syndrome
#2
Thomas G Sutlive, Andrew Golden, Kristin King, William B Morris, John E Morrison, Josef H Moore, Shane Koppenhaver
Background: Patellofemoral pain syndrome (PFPS) is a prevalent knee disorder. A novel yet increasingly popular treatment for PFPS is trigger point dry needling (DN). Purpose: The purpose of this study was to determine if DN is more effective at reducing pain and disability than a sham treatment in individuals with PFPS. Study design: Randomized trial. Materials/Methods: Sixty military health care beneficiaries (36 males) with a clinical diagnosis of PFPS were recruited and completed the study...
June 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/30006929/evaluation-of-a-novel-cricothyroidotomy-introducer-in-a-simulated-obese-porcine-model-a-randomised-crossover-comparison-with-scalpel-cricothyroidotomy
#3
C Yeow, L Greaney, C Foy, W King, B Patel
The Difficult Airway Society 2015 guidelines for management of unanticipated difficulties in tracheal intubation in adults have generated much discussion regarding Plan D: emergency front-of-neck access with a scalpel-bougie cricothyroidotomy technique. There is concern that this technique may not provide an adequate pathway for the bougie and subsequently the tracheal tube, especially in obese patients with deeper airway structures. This could lead to the formation of a false passage, trauma and failure. A novel cricothyroidotomy introducer, 8 mm wide and 170 mm long, with a sharp leading edge and guiding channel to pass a bougie into the trachea, has been designed to complement the scalpel cricothyroidotomy technique...
July 13, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29931087/non-conventional-utilization-of-the-aintree-intubating-catheter-to-facilitate-exchange-between-three-supraglottic-airways-and-an-endotracheal-tube-a-cadaveric-trial
#4
Nicole T Lopez, Sean K McCoy, Christine Carroll, Ellen Jones, Joel A Miller
Background: Two studies by Bledsoe et al and Anand et al reported limited efficacy of the Supraglottic Airway Laryngeal Tube (SALT), which is a supraglottic airway (SGA) specifically designed for blind endotracheal intubation. Miller et al reported a 50% success rate using an Eschmann introducer as an adjunct for blind airway exchange via the laryngeal mask airway (LMA) classic. Another study by Ueki et al found that endotracheal tube (ETT) intubation was faster and less damaging to the airway when the Aintree intubating catheter was used in conjunction with a fiberoptic bronchoscope...
June 19, 2018: Military Medicine
https://www.readbyqxmd.com/read/29889963/are-the-king-lts-laryngeal-tube-and-the-ambu-auraonce-laryngeal-mask-useful-airway-adjuncts-for-military-medics
#5
Danny Regner, Peter Frykholm
BACKGROUND: Airway management is a critical skill that may be essential in the battlefield. The aim of this study was to determine if combat life savers and medics with no or limited clinical experience could provide airway control using the disposable laryngeal suction tube (LTS-D) and the Ambu® AuraOnce ™ disposable laryngeal mask (LMA). METHODS: Eight military medics with limited clinical experience and no airway management experience secured the airway on 19 intrahospital anesthetized patients using the LTS-D and the LMA...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/29714527/comparison-of-the-force-required-for-dislodgement-between-secured-and-unsecured-airways
#6
Curtis Davenport, Christian Martin-Gill, Henry E Wang, James Mayrose, Jestin N Carlson
INTRODUCTION: Airway device placement and maintenance are of utmost importance when managing critically ill patients. The best method to secure airway devices is currently unknown. STUDY OBJECTIVE: We sought to determine the force required to dislodge 4 types of airways with and without airway securing devices. METHODS: We performed a prospective study using 4 commonly used airway devices (endotracheal tube [ETT], laryngeal mask airway [LMA], King laryngeal tube [King], and iGel) performed on 5 different mannequin models...
May 1, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29666693/removal-of-nasogastric-tube-accidentally-stitched-to-roux-en-y-oesophagojejunostomy-following-a-radical-gastrectomy-for-stomach-cancer-case-report-and-review-of-the-literature
#7
Ayman Z Azzam, Kareem A Azzam, Tarek Amin
Nasogastric tubes (NGTs) are important for feeding, stenting and decompression after gastrointestinal surgeries, particularly in the upper gastrointestinal tract. Resistance in the removal of a NGT is a rare surgical complication and may be due to a knot in the tube or a stitch anchoring the tube to an anastomosis . We report a 41-year-old male patient who was admitted to the King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, in 2015 with stomach cancer. He underwent a radical total gastrectomy with a Roux-en-Y oesophagojejunostomy...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29602257/neonatal-oesophageal-perforation-the-role-for-non-operative-management
#8
Kate Hodgson, Andrea Togo, Aideen M Moore, Amanda Moody, Sebastian K King, Augusto Zani
AIM: Isolated oesophageal perforation in neonates is a rare but potentially life-threatening condition. Although management has historically been operative, conservative management (antibiotics, bowel rest, parenteral nutrition) is now more routinely used. The aim of this study was to evaluate the management of this condition in two large neonatal surgical centres. METHODS: A retrospective cohort study was conducted for neonates admitted to The Hospital for Sick Children (Toronto, Canada) or The Royal Children's Hospital (Melbourne, Australia) with a diagnosis of oesophageal perforation, from 2006 to 2016...
March 30, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29430820/controlling-the-diameters-of-nanotubes-self-assembled-from-designed-peptide-bolaphiles
#9
Yurong Zhao, Wei Yang, Dong Wang, Jiqian Wang, Zongyi Li, Xuzhi Hu, Stephen King, Sarah Rogers, Jian R Lu, Hai Xu
Controlling the diameters of nanotubes represents a major challenge in nanostructures self-assembled from templating molecules. Here, two series of bolaform hexapeptides are designed, with Set I consisting of Ac-KI4 K-NH2 , Ac-KI3 NleK-NH2 , Ac-KI3 LK-NH2 and Ac-KI3 TleK-NH2 , and Set II consisting of Ac-KI3 VK-NH2 , Ac-KI2 V2 K-NH2 , Ac-KIV3 K-NH2 and Ac-KV4 K-NH2 . In Set I, substitution for Ile in the C-terminal alters its side-chain branching, but the hydrophobicity is retained. In Set II, the substitution of Val for Ile leads to the decrease of hydrophobicity, but the side-chain β-branching is retained...
March 2018: Small
https://www.readbyqxmd.com/read/29416456/evaluation-of-safety-and-efficacy-of-regional-anesthesia-compared-with-general-anesthesia-in-thoracoscopic-lung-biopsy-procedure-on-patient-with-idiopathic-pulmonary-fibrosis
#10
Waseem M Hajjar, Sami A Al-Nassar, Ghaida S Al-Sugair, Alaa Al-Oqail, Shahd Al-Mansour, Rand Al-Haweel, Adnan W Hajjar
Background: Interstitial lung diseases are diseases that need histology diagnosis or obtaining a lung biopsy to establish the diagnosis. Surgical biopsies are performed usually using the thoracoscopy technique under general anesthesia (GA) although this procedure is still associated with morbidity rate. The aim of this study is to determine the effectiveness and safety of regional anesthesia (RA) compared with GA in thoracoscopic lung biopsy procedures done on patients with idiopathic pulmonary fibrosis (IPF)...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29403565/cell-migration-in-microfabricated-3d-collagen-microtracks-is-mediated-through-the-prometastatic-protein-girdin
#11
Aniqua Rahman-Zaman, Shuo Shan, Cynthia A Reinhart-King
Introduction: In vivo , cancer cells can utilize tube-like microtracks formed within the extracellular matrix (ECM) of the stroma as 'highways' to escape the primary tumor, however very little is known about the molecular mechanisms that govern cell migration through these microtracks. Cell polarization and actin organization are both essential for efficient cell migration and cells are known to migrate very unidirectionally in confined spaces. In this study, we focused on understanding the role of Girdin during unidirectional migration...
February 2018: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29388137/cushioned-density-gradient-ultracentrifugation-c-dguc-a-refined-and-high-performance-method-for-the-isolation-characterization-and-use-of-exosomes
#12
Kang Li, David K Wong, King Yeung Hong, Robert L Raffai
Exosomes represent one class of extracellular vesicles that are thought to be shed by all cell types. Although the exact nature of exosome biogenesis and function remains incompletely understood, they are increasingly recognized as a source of intercellular communication in health and disease. Recent observations of RNA exchange via donor cell-derived exosomes that exert genetic regulation in recipient cells have led to a boon into exosome research. The excitement and promise of exosomes as a new therapeutic avenue for human pathologies remain limited by challenges associated with their isolation from culture media and biofluids...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29388050/aspiration-therapy-as-a-tool-to-treat-obesity-1-to-4-year-results-in-a-201-patient-multi-center-post-market-european-registry-study
#13
Max Nyström, Evzen Machytka, Erik Norén, Pier Alberto Testoni, Ignace Janssen, Jesus Turró Homedes, Jorge Carlos Espinos Perez, Roman Turro Arau
PURPOSE: The objective of this post-market study was to evaluate long-term safety and efficacy of aspiration therapy (AT) in a clinical setting in five European clinics. MATERIALS AND METHODS: The AspireAssist® System (Aspire Bariatrics, Inc. King of Prussia, PA) is an endoscopic weight loss therapy utilizing a customized percutaneous endoscopic gastrostomy tube and an external device to aspirate approximately 30% of ingested calories after a meal, in conjunction with lifestyle counseling...
July 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29373863/mutagenicity-and-lung-toxicity-of-smoldering-vs-flaming-emissions-from-various-biomass-fuels-implications-for-health-effects-from-wildland-fires
#14
Yong Ho Kim, Sarah H Warren, Q Todd Krantz, Charly King, Richard Jaskot, William T Preston, Barbara J George, Michael D Hays, Matthew S Landis, Mark Higuchi, David M DeMarini, M Ian Gilmour
BACKGROUND: The increasing size and frequency of wildland fires are leading to greater potential for cardiopulmonary disease and cancer in exposed populations; however, little is known about how the types of fuel and combustion phases affect these adverse outcomes. OBJECTIVES: We evaluated the mutagenicity and lung toxicity of particulate matter (PM) from flaming vs. smoldering phases of five biomass fuels, and compared results by equal mass or emission factors (EFs) derived from amount of fuel consumed...
January 24, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29364743/comparison-of-the-i-gel-supraglottic-and-king-laryngotracheal-airways-in-a-simulated-tactical-environment
#15
Juan A March, Theresa E Tassey, Noel B Resurreccion, Roberto C Portela, Stephen E Taylor
BACKGROUND: When working in a tactical environment there are several different airway management options that exist. One published manuscript suggests that when compared to endotracheal intubation, the King LT laryngotracheal airway (KA) device minimizes time to successful tube placement and minimizes exposure in a tactical environment. However, comparison of two different blind insertion supraglottic airway devices in a tactical environment has not been performed. This study compared the I-Gel airway (IGA) to the KA in a simulated tactical environment, to determine if one device is superior in minimizing exposure and minimizing time to successful tube placement...
May 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29298241/is-observation-for-traumatic-hemothorax-safe
#16
Leah Demetri, Myriam M Martinez Aguilar, Jordan D Bohnen, Ryan Whitesell, D Dante Yeh, David King, Marc de Moya
BACKGROUND: Eastern Association for the Surgery of Trauma guidelines suggest tube thoracostomy (TT) be considered for all traumatic hemothoraces. However, previous research has suggested that some traumatic hemothoraces may be observed safely. We sought to (1) determine the safety of selective observation for traumatic hemothorax and (2) identify predictors of failed observation. METHODS: All patients with traumatic hemothorax from 2000 to 2014 at a Level I trauma center were identified and categorized by size as small (<300 cc) or large (≥300 cc) based on chest computed tomography (CT) scan measurements...
March 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29245184/evaluation-of-the-use-of-novel-biomarkers-to-augment-antimicrobial-stewardship-program-activities
#17
REVIEW
Kayla R Stover, Rachel M Kenney, Samuel Travis King, Alan E Gross
As antimicrobial stewardship increasingly receives worldwide attention for improving patient care by optimizing antimicrobial therapy, programs are evaluating new tools that may augment antimicrobial stewardship activities. Biomarkers are objective, accurate, and reproducible measures that provide information about medical conditions. A systematic literature search using PubMed/MEDLINE databases was performed to evaluate the use of novel biomarkers as additions to the antimicrobial stewardship armamentarium...
February 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29056498/a-comparison-of-3-videolaryngoscopes-for-double-lumen-tube-intubation-in-humans-by-users-with-mixed-experience-a-randomized-controlled-study
#18
Mohamed R El-Tahan, Alaa M Khidr, Ihab S Gaarour, Saeed A Alshadwi, Talal M Alghamdi, Abdulmohsen Al'ghamdi
OBJECTIVES: To test the hypothesis that laryngoscopy using the Airtraq (Prodol Limited, Viscaya, Spain) or King Vision laryngoscope (KVL) (Ambu A/S, Ballerup, Denmark) would result in a shorter time for successful double-lumen endobronchial tube (DLT) intubation by users with mixed experience than the time required using the Macintosh or GlideScope (Verathon Inc., Bothell, WA) laryngoscopes. DESIGN: A randomized, prospective, blind study. SETTING: A single university hospital...
February 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29044830/optimal-management-of-apparatus-dead-space-in-the-anesthetized-infant
#19
REVIEW
Michael R King, Jeffrey M Feldman
Mechanical ventilation of the anesthetized infant requires careful attention to equipment and ventilator settings to assure optimal gas exchange and minimize the potential for lung injury. Apparatus dead space, defined as dead space resulting from devices placed between the endotracheal tube and the Y-piece of the breathing circuit, is the primary source of dead space controlled by the clinician. Due to the small tidal volumes required by infants and neonates, it is easy to create excessive apparatus dead space resulting in unintended hypercarbia or increased minute ventilation in an effort to achieve a desirable PCO2 ...
December 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28895317/assessment-of-a-noninvasive-optical-photoplethysmography-imaging-device-with-dynamic-tissue-phantom-models
#20
C Ikenna Nwafor, Kevin D Plant, Darlene R King, Brian P McCall, John J Squiers, Wensheng Fan, J Michael DiMaio, Jeffrey E Thatcher
Noncontact photoplethysmography (PPG) has been studied as a method to provide low-cost, noninvasive, two-dimensional blood oxygenation measurements and medical imaging for a variety of near-surface pathologies. To evaluate this technology in a laboratory setting, dynamic tissue phantoms were developed with tunable parameters that mimic physiologic properties of the skin, including blood vessel volume change, pulse wave frequency, and tissue scattering and absorption. Tissue phantoms were generated using an elastic tubing to represent a blood vessel where the luminal volume could be modulated with a pulsatile fluid flow...
September 2017: Journal of Biomedical Optics
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