José Manuel Serrano Simón, Carolina Joya Montosa, Juan Francisco Martínez Carmona, Manuel Jesús Delgado Amaya, Javier Luna Castro, Ashlen Rodríguez Carmona, José Castaño Pérez, Marina Rodríguez Delgado, Guillermo Besso Centeno, José Antonio Benítez Lozano
BACKGROUND: High drive and high effort during spontaneous breathing can generate patient self-inflicted lung injury (P-SILI) due to uncontrolled high transpulmonary and transvascular pressures, with deterioration of respiratory failure. P-SILI has been demonstrated in experimental studies and supported in recent computational models. Different treatment strategies have been proposed according to the phenotype of elastance of the respiratory system (Ers) for patients with COVID-19. This study aimed to investigate the effect of three spontaneous ventilation modes on respiratory drive and muscle effort in clinical practice and their relationship with different phenotypes...
September 8, 2023: BMC Pulmonary Medicine