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Outer root sheath

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https://www.readbyqxmd.com/read/27904857/t-cadherin-expression-in-the-epidermis-and-adnexal-structures-of-normal-skin
#1
Stanislaw Buechner, Paul Erne, Therese J Resink
BACKGROUND: T-cadherin is an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules. The role of T-cadherin in biology of the skin is poorly understood. Expression of T-cadherin in basal keratinocytes and dermal blood vessels of the healthy epidermis has been demonstrated, but studies on expression in skin appendages are rare. METHODS: We conducted an immunohistochemical analysis of T-cadherin expression in the epidermis and adnexal structures of normal skin...
September 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#2
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27733339/expression-and-localization-of-gpr143-in-sheep-skin
#3
Chen Tianzhi, Zhao Bingling, Liu Yu, Zhao Yuanyuan, Wang Haidong, Fan Ruiwen, Wang Pengchao, Dong Changsheng
G-protein coupled receptor143 (GPR143) plays an important role in melanogenesis. In this study, we investigated the expression pattern and localization of GPR143 in skin of sheep with different coat colors and explored the correlation between GPR143 gene and coat color. The mRNA level and protein level of GPR143 in skin of sheep with different coat colors were detected by qRT-PCR and immunoblotting separately while the localization of GPR143 in sheep skin was detected by immunofluorescence assay following optical density analysis...
July 20, 2016: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/27690000/ocular-albinism-type-1-regulates-melanogenesis-in-mouse-melanocytes
#4
Tianzhi Chen, Haidong Wang, Yu Liu, Bingling Zhao, Yuanyuan Zhao, Ruiwen Fan, Pengchao Wang, Changsheng Dong
To investigate whether ocular albinism type 1 (OA1) is differentially expressed in the skin of mice with different coat colors and to determine its correlation with coat color establishment in mouse, the expression patterns and tissue distribution characterization of OA1 in the skin of mice with different coat colors were qualitatively and quantitatively analyzed by real-time quantitative PCR (qRT-PCR), immunofluorescence staining and Western blot. The qRT-PCR analysis revealed that OA1 mRNA was expressed in all mice skin samples tested, with the highest expression level in brown skin, a moderate expression level in black skin and the lowest expression level in gray skin...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27683091/linear-trichilemmomas-on-the-ankle-of-a-28-year-old-female
#5
Jessica L Gonzalez, Natalia Plotnikova, Andrew Seymour, Ciaran M Mannion, Richard Danialan, David Rosmarin
Trichilemmomas are benign cutaneous proliferations derived from the outer root sheath of the hair follicle. They most often occur on the head and neck region and show a female predominance. When multiple, they are associated with Cowden syndrome (CS), a rare disorder due to an autosomal dominant germline mutation in PTEN (phosphatase and tensin homolog on chromosome 10), a tumor suppressor gene. Trichilemmomas outside of the head and neck region are rare, and as such, the association with CS is not clear. A 28-year-old healthy female with no significant family history of cancer presented to her dermatologist with multiple erythematous papules on the left anterior ankle, starting at birth...
September 28, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27611344/daughters-of-the-enamel-organ-development-fate-and-function-of-the-stratum-intermedium-stellate-reticulum-and-outer-enamel-epithelium
#6
Hui Liu, Xiulin Yan, Mirali Pandya, Xianghong Luan, Thomas G H Diekwisch
The tooth enamel organ (EO) is a complex epithelial cell assembly involved in multiple aspects of tooth development, including amelogenesis. The present study focuses on the role of the nonameloblast layers of the EO, the stratum intermedium, the stellate reticulum, and the outer enamel epithelium (OEE). The secretory stage stratum intermedium was distinguished by p63-positive epithelial stem cell marks, highly specific alkaline phosphatase labeling, as well as multiple desmosomes and gap junctions. At the location of the presecretory stage stellate reticulum, the pre-eruption EO prominently featured the papillary layer (PL) as a keratin immunopositive network of epithelial strands between tooth crowns and oral epithelium...
September 9, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27601859/a-study-of-noncultured-extracted-hair-follicle-outer-root-sheath-cell-suspension-for-transplantation-in-vitiligo
#7
Aarti N Shah, Ritu K Marfatia, Siddhartha S Saikia
CONTEXT: Vitiligo surgeries have come a long way from tissue grafts to cultured and non cultured cell transplantation. Extracted hair follicle outer root sheath cell transplantation (EHF ORS) suspension is more enriched with melanocyte. In a hair bulb, there is one melanocyte for every five keratinocytes which is much higher than the epidermal melanin unit. AIMS: To analyse the effectiveness of cultured EHF ORS and to perform objective evaluation based on clinical improvement & photographic evidence...
April 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/27587291/localization-of-the-rabies-virus-antigen-in-merkel-cells-in-the-follicle-sinus-complexes-of-muzzle-skins-of-rabid-dogs
#8
Taichi Shimatsu, Harumi Shinozaki, Kazunori Kimitsuki, Nozomi Shiwa, Daria L Manalo, Rodolfo C Perez, Joselito E Dilig, Kentaro Yamada, Hassadin Boonsriroj, Satoshi Inoue, Chun-Ho Park
The direct fluorescent antibody test (dFAT) on fresh brain tissues is the gold standard for rabies virus antigen detection in dogs. However, this method is laborious and holds a high risk of virus exposure for the experimenter. Skin biopsies are useful for the diagnosis of humans and animals. In mammals, the tactile hair, known as the follicle-sinus complex (FSC), is a specialized touch organ that is abundant in the muzzle skin. Each tactile hair is equipped with more than 2,000 sensory nerve endings. Therefore, this organ is expected to serve as an alternative postmortem diagnostic material...
November 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27550230/a-rare-cutaneous-adnexal-neoplasm-cystic-panfolliculoma
#9
Brett Neill, Colby Bingham, Kara Braudis, Susan Zurowski
A cystic panfolliculoma is a benign follicular neoplasm which recapitulates several portions of the hair follicle. The patient was a 64-year-old Caucasian female who presented with a new growth on her right forearm. The lesion had slowly enlarged over the previous 11 months. She complained of it bleeding on several occasions and being very tender when touched. On exam was an 8 mm firm pink papule which appeared slightly eroded. The growth was excised in clinic. Histology showed a well-circumscribed neoplasm with foci of matrical, infundibular, inner and outer root sheath differentiation...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27543057/matriptase-and-prostasin-are-expressed-in-human-skin-in-an-inverse-trend-over-the-course-of-differentiation-and-are-targeted-to-different-regions-of-the-plasma-membrane
#10
Chih-Hsin Lai, Shun-Cheng Chang, Yen-Ju Chen, Yi-Jie J Wang, Ying-Jun J Lai, Hsiang-Hua D Chang, Eric B Berens, Michael D Johnson, Jehng-Kang Wang, Chen-Yong Lin
Matriptase and prostasin, acting as a tightly coupled proteolytic cascade, were reported to be required for epidermal barrier formation in mouse skin. Here we show that, in human skin, matriptase and prostasin are expressed with an inverse pattern over the course of differentiation. Matriptase was detected primarily in epidermal basal keratinocytes and the basaloid cells in the outer root sheath of hair follicles and the sebaceous gland, where prostasin was not detected. In contrast, prostasin was detected primarily in differentiated cells in the epidermal granular layer, the inner root sheath of hair follicles, and the sebaceous gland, where matriptase expression is negligible...
October 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27498544/cd99-is-strongly-expressed-in-basal-cells-of-the-normal-adult-epidermis-and-some-subpopulations-of-appendages-comparison-with-developing-fetal-skin
#11
Gawon Choi, Jin Roh, Chan-Sik Park
BACKGROUND: CD99 is a cell surface transmembrane glycoprotein expressed in various tissues. CD99 is differentially expressed between subpopulations of each tissue and is highly expressed in certain hematopoietic and precursor cells. However, there has been no comprehensive study of CD99 expression in normal skin. We evaluated CD99 expression in normal human skin and developing fetal skin. METHODS: Seventy-five adult skin samples containing normal skin and eight fetal skin samples of different gestational ages were collected...
September 2016: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27431242/discovery-of-hap-stem-cells
#12
Lingna Li, Robert M Hoffman
Cells expressing the stem cell marker, nestin, were selectively labeled in transgenic mice by placing green fluorescent protein (GFP) under the control of the nestin promoter in transgenic mice. In these transgenic mice, neural and other stem cells brightly expressed GFP. The mice were termed nestin-driven GFP (ND-GFP) mice. During early anagen or growth phase of the hair follicle, ND-GFP appeared in the permanent upper hair follicle immediately below the sebaceous glands in the follicle bulge. The relatively small, oval-shaped, nestin-expressing cells in the bulge area surrounded the hair shaft and were interconnected by short dendrites...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27431240/introduction-to-hair-follicle-associated-pluripotent-stem-cells
#13
Robert M Hoffman
Nestin-expressing stem cells of the hair follicle, discovered by our laboratory, have been shown to be able to form outer-root sheaths of the follicle as well as neurons and many other non-follicle cell types. We have termed the nestin-expressing stem cells of the hair follicle as hair-follicle-associated pluripotent (HAP) stem cells. We have shown that the HAP stem cells from the hair follicle can effect the repair of peripheral nerve and spinal cord injury. The hair follicle stem cells differentiate into neuronal and glial cells after transplantation to the injured peripheral nerve and spinal cord, and enhance injury repair and locomotor recovery...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27411280/-co-transplantation-of-mouse-epidermis-and-dermis-cells-in-inducing-hair-follicle-regeneration
#14
Lin Chen, Jiafei Xi, Daqing Liu, Xiuyuan Zhang, Yang Lü, Jing Li, Jingxue Wang, Junnian Zhou, Xue Nan, Wen Yue, Xuetao Pei
OBJECTIVE: To investigate the co-transplantation of C57-green fluorescent protein (GFP) mouse epidermis and dermis cells subcutaneously to induce the hair follicle regeneration. METHODS: C57-GFP mouse epidermis and dermis were harvested for isolation the mouse epidermis and dermis cells. The morphology of epidermis and dermis mixed cells at ratio of 1:1 of adult mouse, dermis cells of adult mouse, cultured 3rd generation dermis cells were observed by fluorescence microscope...
April 2016: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/27409726/melanocytes-from-the-outer-root-sheath-of-human-hair-and-epidermal-melanocytes-display-improved-melanotic-features-in-the-niche-provided-by-cgel-oligomer-cross-linked-gelatin-based-hydrogel
#15
Katharina Sülflow, Marie Schneider, Tina Loth, Christian Kascholke, Michaela Schulz-Siegmund, Michael C Hacker, Jan-Christoph Simon, Vuk Savkovic
Non-invasively based cell treatments of depigmented skin disorders are largely limited by means of cell sampling as much as by their routes of application. Human melanocytes cultivated from the outer root sheath of hair follicle (HUMORS) are among the cell types that fit the non-invasive concept by being cultivated out of a minimal sample: hair root. Eventual implementation of HUMORS as a graft essentially depends on a choice of suitable biocompatible, biodegradable carrier that would mechanically and biologically support the cells as transient niche and facilitate their engraftment...
July 13, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27403361/atypical-proliferating-trichilemmal-cyst-with-malignant-breast-skin-transformation-a-case-report-and-review-of-the-literature
#16
Marino Antonio Capurso-García, Verónica Bautista-Piña, Alan Pomerantz, Javier Andrés Galnares-Olalde, Ruben Blachman-Braun, Sergio Rodríguez-Rodríguez, Monica Goldberg-Murow
Proliferating trichilemmal tumors (PTTs) are benign adnexal skin neoplasms that arise from the outer root sheath of the hair follicle. These tumors are most commonly observed on the scalp and occur, most of the time, in elderly women. Malignant transformation of these neoplasms is a rare event; less than 50 cases have been reported in the English medical literature. We present the case of a 39-year-old Hispanic woman with a tumor located on the skin of one of her breasts that in her third surgical procedure the histologic examination revealed the presence of a malignant proliferating trichilemmal tumor (MPTT)...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27352380/epidermal-growth-factor-promotes-proliferation-and-migration-of-follicular-outer-root-sheath-cells-via-wnt-%C3%AE-catenin-signaling
#17
Haihua Zhang, Weixiao Nan, Shiyong Wang, Tietao Zhang, Huazhe Si, Fuhe Yang, Guangyu Li
BACKGROUND/AIMS: To investigate the effect and molecular mechanism of EGF on the growth and migration of hair follicle outer root sheath (ORS) cells. METHODS: Intact anagen hair follicles were isolated from mink skin and cultured with EGF in vitro to measure ORS daily growth. Meanwhile, purified primary ORS cells were treated or transfected with EGF, and their proliferation and migration were assessed by MTT assay and transwell assay, respectively. The signaling pathway downstream of EGF was characterized by using the Wnt/β-catenin signaling inhibitor, XAV-939...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27222613/localizations-of-%C3%AE-actins-in-skin-hair-vibrissa-arrector-pili-muscle-and-other-hair-appendages-of-developing-rats
#18
Kiyokazu Morioka, Hiromi Takano-Ohmuro
Six isoforms of actins encoded by different genes have been identified in mammals including α-cardiac, α-skeletal, α-smooth muscle (α-SMA), β-cytoplasmic, γ-smooth muscle (γ-SMA), and γ-cytoplasmic actins (γ-CYA). In a previous study we showed the localization of α-SMA and other cytoskeletal proteins in the hairs and their appendages of developing rats (Morioka K., et al. (2011) Acta Histochem. Cytochem. 44, 141-153), and herein we determined the localization of γ type actins in the same tissues and organs by immunohistochemical staining...
April 28, 2016: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/27185495/15-deoxy-prostaglandin-j2-the-nonenzymatic-metabolite-of-prostaglandin-d2-induces-apoptosis-in-keratinocytes-of-human-hair-follicles-a-possible-explanation-for-prostaglandin-d2-mediated-inhibition-of-hair-growth
#19
Hyun Woo Joo, Yoo Ri Kang, Mi Hee Kwack, Young Kwan Sung
Recent studies have shown that prostaglandin D2 (PGD2) and its nonenzymatic metabolite, 15-deoxy-Δ(12,14)-prostaglandin J2 (15-dPGJ2), inhibit in vitro growth of explanted human hair follicles and inhibit hair growth in mice through the GPR44 (DP2). However, the underlying mechanism is still unclear. In this study, we first investigated the expression of DP2 in human hair follicles and in cultured follicular cells. We found that DP2 is strongly expressed in the outer root sheath (ORS) cells and weakly expressed in the dermal papilla (DP) cells...
July 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27110266/decoction-and-fermentation-of-selected-medicinal-herbs-promote-hair-regrowth-by-inducing-hair-follicle-growth-in-conjunction-with-wnts-signaling
#20
Su Kil Jang, Seung Tae Kim, Do Ik Lee, Jun Sub Park, Bo Ram Jo, Jung Youl Park, Jong Heo, Seong Soo Joo
It is well recognized that regulating the hair follicle cycle in association with Wnt signaling is one of the most interesting targets for promoting hair regrowth. In this study, we examined whether selected herbal medicines processed by decoction and fermentation promote hair growth by upregulating the number and size of hair follicles and Wnt signaling, including activation of β-catenin and Akt in telogen-synchronized C57BL/6N mice. The results revealed that the fermented extract after decoction (FDE) more effectively promoted hair growth than that of a nonfermented extract (DE)...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
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