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Lymph node metastasis colorectal

Rui Zheng, Quanbo Liu, Tianxu Wang, Lili Wang, Yong Zhang
Background: FAM98A, a novel protein, is expressed in ovarian and colorectal cancer tissues. However, the association between FAM98A expression and the clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains undetermined. Materials and methods: The FAM98A expression pattern was determined in NSCLC samples and corresponding adjacent normal lung tissues using immunohistochemical staining and Western blotting. The association of FAM98A expression with clinicopathological characteristics was measured in 131 NSCLC samples...
2018: Cancer Management and Research
Meryem Gülfem Öner, Matjaz Rokavec, Markus Kaller, Nassim Bouznad, David Horst, Thomas Kirchner, Heiko Hermeking
BACKGROUND & AIMS: Combined inactivation of the microRNA 34a gene (MIR34A, by methylation) and the TP53 gene (by mutation or deletion) is observed in 50% of colorectal tumors that progress to distant metastases. We studied mice with intestinal disruption of Mir34a and Tp53 to investigate mechanisms of colorectal carcinogenesis and identify strategies to block these processes. METHODS: Mice with disruption of Mir34a and/or Tp53 specifically in intestinal epithelial cells (Mir34aΔIEC mice, Tp53ΔIEC mice, and Mir34aΔIEC /Tp53ΔIEC mice) and controls (Mir34aFl/Fl /Tp53Fl/Fl ) were given azoxymethane to induce colorectal carcinogenesis...
August 9, 2018: Gastroenterology
Mingzuo Jiang, Bing Xu, Xiaowei Li, Yulong Shang, Yi Chu, Weijie Wang, Di Chen, Nan Wu, Sijun Hu, Song Zhang, Mengbin Li, Kaichun Wu, Xiaoyong Yang, Jie Liang, Yongzhan Nie, Daiming Fan
Advanced colorectal cancer (CRC) is one of the deadliest cancers, and the 5-year survival rate of patients with metastasis is extremely low. The epithelial-mesenchymal transition (EMT) is considered essential for metastatic CRC, but the fundamental molecular basis underlying this effect remains unknown. Here, we identified that O-GlcNAcylation, a unique posttranslational modification (PTM) involved in cancer metabolic reprogramming, increased the metastatic capability of CRC. The levels of O-GlcNAcylation were increased in the metastatic CRC tissues and cell lines, which likely promoted the EMT by enhancing EZH2 protein stability and function...
August 9, 2018: Oncogene
Yifan Lian, Changsheng Yan, Hongzhi Xu, Jiebin Yang, Yang Yu, Jing Zhou, Yongguo Shi, Jianlin Ren, Guozhong Ji, Keming Wang
Emerging evidence has proven that long noncoding RNAs (lncRNAs) play important roles in human colorectal cancer (CRC) biology, although few lncRNAs have been characterized in CRC. Therefore, the functional significance of lncRNAs in the malignant progression of CRC still needs to be further explored. In this study, through analyzing TCGA RNA sequencing data and other publicly available microarray data, we found a novel lncRNA, LINC00460, whose expression was significantly upregulated in CRC tissues compared to adjacent normal tissues...
July 6, 2018: Molecular Therapy. Nucleic Acids
Takashi Murakami, Naoto Sakamoto, Akihito Nagahara
Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in colorectal carcinomas with BRAF mutations, methylation for DNA repair genes, a CpG island methylator phenotype, and high levels of microsatellite instability. Some of these lesions can rapidly become dysplastic or invasive carcinomas that exhibit high lymphatic invasion and lymph node metastasis potentials. Detecting serrated lesions, including SSA/Ps with and without dysplasia/carcinoma, is critical, but SSA/Ps can be difficult to detect, are inconsistently identified by endoscopists and pathologists, and are often incompletely resected...
August 7, 2018: World Journal of Gastroenterology: WJG
Tamotsu Sugai, Noriyuki Uesugi, Yuriko Kitada, Noriyuki Yamada, Mitsumasa Osakabe, Makoto Eizuka, Ryo Sugimoto, Yasuko Fujita, Keisuke Kawasaki, Eiichiro Yamamoto, Hiroo Yamano, Hiromu Suzuki, Takayuki Matsumoto
Objective: Recent studies have shown that cancer-associated fibroblasts (CAFs) and the epithelial-mesenchymal transition (EMT) play important roles in the progression and metastasis of CRC. Although prediction of lymph node metastasis in submucosal invasive colorectal cancer (SiCRC) is important, the relationships of CAF and EMT with lymph node metastasis of SiCRC have not yet been examined. Here, we aimed to analyze the expression patterns of CAF- and EMT-related proteins in SiCRC. Materials and Methods: The expression of CAF-related markers, including α-smooth muscle actin, CD10, podoplanin, fibroblast specific protein 1, and adipocyte enhancer-binding protein 1, and EMT-related proteins [zinc finger protein SNAI2 (ZEB1) and twist-related protein 1 (TWIST1) in SiCRC with (n = 29) or without (n = 80) lymph node metastasis was examined by immunohistochemistry...
2018: Journal of Cancer
Kazushige Kawai, Hiroaki Nozawa, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kenichi Sugihara, Toshiaki Watanabe
BACKGROUND: Although a number of studies have been conducted to investigate factors affecting colon cancer recurrence and patient overall survival after surgical treatment, no prognostic risk models have been proposed for predicting survival specifically after postsurgical recurrence. OBJECTIVE: We aimed to identify factors affecting the survival of the patients with recurrent colon cancer and to construct a nomogram for predicting their survival. DESIGN: This was a retrospective study...
September 2018: Diseases of the Colon and Rectum
Bufan Xiao, Zhaohao Huang, Ruihao Zhou, Jingtao Zhang, Bentong Yu
BACKGROUND The long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is expressed in solid malignant tumors. The aim of this systematic review and meta-analysis was to determine whether expression of the lncRNA SNHG1 was associated with prognosis in patients with malignancy. MATERIAL AND METHODS A literature review from Jan 1970 to July 2018 identified publications in the English language. Databases searched included: PubMed, OVID, Web of Science, the Cochrane Database, Embase, EBSCO, Google Scholar...
August 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Caroline MacCallum, Nigel Da Silva, Peter Gibbs, Benjamin N J Thomson, Anita Skandarajah, Ian Hayes
BACKGROUND: Administrative data are routinely captured for each hospital admission and may serve as an alternative source for populating databases. This study aims to determine the accuracy of administrative data to provide tumour characteristics and short-term post-operative outcomes, after a colorectal cancer (CRC) resection, compared with clinical data. METHODS: A retrospective study of all CRC resections at a single hospital from 1 January 2008 to 31 December 2013 was conducted...
August 3, 2018: ANZ Journal of Surgery
Kangwen Cheng, Zhenguo Zhao, Guihe Wang, Jian Wang, Weiming Zhu
Long non‑coding RNAs (lncRNAs) are mainly involved in diverse biological processes in human malignancies. The expression profile and underlying mechanism of the lncRNA growth arrest specific transcript 5 (GAS5) in colorectal cancer (CRC) are poorly understood. Here, we investigated the role of GAS5 in human CRC tissues. lncRNA GAS5 was specifically downregulated in CRC tissues and cell lines. Reduced GAS5 levels were significantly associated with advanced clinical stage and lymph node metastasis in CRC...
July 20, 2018: Oncology Reports
Mariana Campos-da-Paz, Jose GarrofeDorea, Alexsandro Sobreira Galdino, Zulmira Guerrero Marques Lacava, Maria de Fatima Menezes Almeida Santos
Carcinoembryonic antigen (CEA) is a prognostic marker in colorectal cancer (CRC) for tumor diagnosis and monitoring response to therapy. High CEA levels are specifically associated with CRC progression and liver metastasis. Due to its differential expression between cancer and healthy tissues, and between positive and negative lymph nodes CEA has been explored for new cancer therapy and diagnosis approaches. We revised the literature on CEA role in CRC as well as the patents relating to CEA targeting for cancer management...
July 30, 2018: Recent Patents on Biotechnology
Z-K Wang, Z-W Cheng, S-J Chen, X-G Zhu, Y-P Gu, X-D Yang, L Sun, W-T Liu, Y-J Zhang, J-F Yuan, K-J Tian, Y-Z Yao, S-B He
OBJECTIVE: Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Emerging evidence has verified that Rab1A plays an oncogenic role in several human malignancies including breast cancer, lung cancer, and hepatocellular carcinomas. However, the clinical significance and prognostic impact of Rab1A in CRC is still unclear. PATIENTS AND METHODS: We initiated our investigation by immunohistochemistry and Western blot analysis to confirm Rab1A expression in CRC tissues...
July 2018: European Review for Medical and Pharmacological Sciences
D-S Wang, B Zhong, M-S Zhang, Y Gao
OBJECTIVE: Circulating microRNAs (miRNAs) have been reported as biomarkers for the early detection of colorectal cancer (CRC). We aimed at evaluating the diagnostic and prognostic value of serum miR-103 in CRC patients. PATIENTS AND METHODS: Quantitative reverse-transcription PCR (qRT-PCR) was applied to measure the miR-103 levels in blood samples of 96 patients and 60 controls. RESULTS: Our results demonstrated that serum miR-103 was overexpressed in CRC subjects and the receiver operating characteristic (ROC) curve analysis showed that serum miR-103 could differentiate CRC cases from controls with relatively high accuracy...
July 2018: European Review for Medical and Pharmacological Sciences
Minrui Luo, Chuyuan Hong, Yaguang Zhou, Yanrui Liang, Zhihua Liang, Zhen Zhong, Yisheng Wei
OBJECTIVE: To examine the association between the genotype (LL, LS and SS) of serotonin transporter promoter gene polymorphism(5-HTTLPR) and clinicopathological factors, and to investigate the effect of 5-HTTLPR on the prognosis of colorectal cancer patients. METHODS: Data of peripheral blood samples of 161 colorectal cancer patients at the Second Affiliated Hospital of Guangzhou Medical University from October 2009 to January 2014 were collected retrospectively...
July 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Dejun Fan, Yuming Rong, Yifeng Zou, Feng Zhang, Xutao Lin, Xiaojian Wu
OBJECTIVE: To investigate the role of miR-26b in the invasion and metastasis of colorectal cancer. METHODS: Data of public chip databases were extracted to analyze the relationship between miR-26b expression and lymph node metastasis. Two types of colorectal cancer cell lines, Caco2 and DLD1, were selected, and the miR-26b-high colorectal cancer cell line was constructed using the method of lentivirus infection. The effects of up-regulating miR-26b expression on the invasion and metastasis of colorectal cancer cells were analyzed by Transwell migration and invasion experiment and wound healing assay...
July 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Yu Yoshida, Takanori Goi, Hidetaka Kurebayashi, Mitsuhiro Morikawa, Yasuo Hirono, Kanji Katayama
Molecular tumor biomarkers hold considerable promise for accurately predicting colorectal cancer (CRC) recurrence and progression. Prokineticin 2 (PROK2) may be associated with angiogenesis and tumor formation in some malignant tumors. However, its prognostic value remains unknown. We focused on the association between PROK2 expression and clinical characteristics of CRC to assess value of PROK2 as a potential biomarker for stage I-III CRC patients prognosis. Between 1992 and 2006, 436 consecutive patients with stage I-III CRC treated with curative resection were included...
July 10, 2018: Oncotarget
Zhong Zheng, Huiping Yu, Qin Huang, Hongyan Wu, Yao Fu, Jiong Shi, Ting Wang, Xiangshan Fan
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is a downstream target gene of the Wnt/β-catenin signaling pathway and identified as a marker of cancer stem-like cells of colorectal carcinoma (CRC). Here, the heterogeneous expression pattern of Lgr5 and its clinical significance were studied by the method of immunohistochemistry in 204 CRC tumors at various pTNM stages. Lgr5 expression was found in 82.4% (168/204) cases, significantly more common in neoplastic cells at the infiltrative front ( n = 59...
July 10, 2018: Oncotarget
Kazunosuke Yamada, Shunsuke Tsukamoto, Hiroki Ochiai, Dai Shida, Yukihide Kanemitsu
INTRODUCTION: The clinical benefit of extended lymphadenectomy for synchronous extraregional lymph node metastasis, such as para-aortic lymph node (PALN) metastasis in colorectal cancer, remains highly controversial. AIM: To evaluate the clinical benefit of PALN dissection in colorectal cancer patients with synchronous PALN metastasis with or without multiorgan metastases. METHODS: Thirty-six patients with pathologically positive PALN metastasis below the renal veins who underwent concurrent PALN dissection and primary colorectal cancer resection from January 1984 through September 2011 at the National Cancer Center Hospital in Tokyo, Japan, were included in this retrospective cohort study...
July 25, 2018: Digestive Surgery
Daiji Ikuta, Toru Miyake, Tomoharu Shimizu, Hiromichi Sonoda, Ken-Ichi Mukaisho, Aya Tokuda, Tomoyuki Ueki, Hiroyuki Sugihara, Masaji Tani
Background: Tumor microenvironment including fibrosis has a pivotal role in cancer growth and distant metastasis. Fibrosis is a known risk factor for carcinogenesis, but its biological role in disease invasion and metastasis in colorectal cancer (CRC) remains unclear. In particular, there is no report on how fibrosis of metastatic lymph nodes (MLNs) in CRC contributes to prognosis. Methods: We reviewed 94 colorectal adenocarcinoma patients with MLNs who underwent colectomy...
July 3, 2018: Oncotarget
Yi Pan, Joanna Hung Man Tong, Raymond Wai Ming Lung, Wei Kang, Johnny Sheung Him Kwan, Wing Po Chak, Ka Yee Tin, Lau Ying Chung, Feng Wu, Simon Siu Man Ng, Tony Wing Chung Mak, Jun Yu, Kwok Wai Lo, Anthony Wing Hung Chan, Ka Fai To
BACKGROUND: Patients with colorectal cancer (CRC) have a high incidence of regional and distant metastases. Although metastasis is the main cause of CRC-related death, its molecular mechanisms remain largely unknown. METHODS: Using array-CGH and expression microarray analyses, changes in DNA copy number and mRNA expression levels were investigated in human CRC samples. The mRNA expression level of RASAL2 was validated by qRT-PCR, and the protein expression was evaluated by western blot as well as immunohistochemistry in CRC cell lines and primary tumors...
July 23, 2018: Molecular Cancer
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