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Lymph node metastasis colorectal

Ruohua Chen, Yining Wang, Xiang Zhou, Gang Huang, Jianjun Liu
Purpose: We evaluated the prognostic value of preoperative 18 F-FDG uptake by suspected lymph nodes (LNs) using 18 F-FDG PET/CT in colorectal cancer patients. Methods: Patients with CRC underwent 18 F-FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the 18 F-FDG maximum standardized uptake value (SUVmax) in the suspected LNs (SUVLN ) on 18 F-FDG PET/CT. Results: Clinical data, treatment modalities, and results from 90 CR C patients were reviewed...
2018: Contrast Media & Molecular Imaging
Feng-Wei Wang, Chen-Hui Cao, Kai Han, Yong-Xiang Zhao, Mu-Yan Cai, Zhi-Cheng Xiang, Jia-Xing Zhang, Jie-Wei Chen, Li-Ping Zhong, Yong Huang, Su-Fang Zhou, Xiao-Han Jin, Xin-Yuan Guan, Rui-Hua Xu, Dan Xie
The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC), but remains a challenge for drug development. Long non-coding RNAs (lncRNAs) are invaluable in identifying cancer pathologies, and providing therapeutic options for cancer patients. Here, we identified a lncRNA (lncRNA-APC1) activated by APC through lncRNA microarray screening, and examined its expression among a large cohort of CRC tissues. A decrease in lncRNA-APC1 expression was positively associated with lymph node and/or distant metastasis, a more advanced clinical stage, as well as a poor prognosis of CRC patients...
December 4, 2018: Journal of Clinical Investigation
É J Ryan, B Creavin, Y L Khaw, M E Kelly, H M Mohan, R Geraghty, E J Ryan, R Kennelly, A Hanly, S T Martin, D Fennelly, R McDermott, D Gibbons, P R O'Connell, K Sheahan, D C Winter
Background: Caudal-related homeobox transcription factor 2 (CDX2) is an intestine-specific transcription factor implicated in tumour differentiation, proliferation, cell adhesion and migration. Negative CDX2 status (CDX2-) is associated with worse prognosis in colorectal cancer and may identify high-risk stage II disease that benefits from adjuvant chemotherapy. This observational study investigated whether CDX2- is associated with prognosis or response to chemotherapy in the mismatch repair-deficient (dMMR) phenotype of colorectal cancer...
December 2018: BJS open
Dao-Jiang Li, Zhi-Cai Feng, Xiao-Rong Li, Gui Hu
AIM: To investigate whether promoter methylation is responsible for the silencing of formin 2 ( FMN2 ) in colorectal cancer (CRC) and to analyze the association between FMN2 methylation and CRC. METHODS: We first identified the expression levels and methylation levels of FMN2 in large-scale human CRC expression datasets, including GEO and TCGA, and analyzed the relationship between the expression and methylation levels. Then, the methylation levels in four CpG regions adjacent to the FMN2 promoter were assessed by MethylTarget™ assays in CRC cells and in paired colorectal tumor samples and adjacent nontumor tissue samples...
November 28, 2018: World Journal of Gastroenterology: WJG
F Yuan, W Wang, J Xu
The novel colorectal neoplasia differentially expressed lncRNA (CRNDE) has been discovered in many solid tumors. We conducted this systematic review and meta-analysis to illuminate the function of CRNDE in cancer. Published articles were identified by electronic search of PubMed, EMBASE, and MEDLINE using the keywords "cancer or carcinoma or neoplasm or tumor" and "long noncoding RNA CRNDE or noncoding RNA CRNED or CRNDE". Hazard ratios (HRs), standard errors (SEs) and their corresponding 95% confidence intervals (CIs) were estimated from study survival curves...
August 9, 2018: Neoplasma
Ian Nora, Ravi Shridhar, Jamie Huston, Kenneth Meredith
Background: Accurate predictors of locally advanced and recurrence disease in patients with gastrointestinal cancer are currently lacking. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have emerged as possible markers for predicting recurrence in these patients. In this study, we sought to evaluate the utility of NLR and PLR in predicting the presence of regional nodal disease, metastasis and systemic recurrence in patients with gastrointestinal malignancies...
October 2018: Journal of Gastrointestinal Oncology
Yangyang Chen, Yifei Liu, Yanhong Zhou, Hongxia You
The occurrence of colorectal cancer (CRC) is associated with a variety of oncogenes and tumor‑suppressor genes. As a tumor‑suppressor gene, the liver kinase B1 gene (LKB1, also known as serine/threonine kinase 11, STK11) is closely related to tumor angiogenesis, invasion and metastasis, but its molecular mechanisms remain unclear. The aim of the present study was to investigate the effects of LKB1 on the invasion and metastasis of CRC, and to explore its molecular mechanisms. By detecting the expression of LKB1 in CRC, we can provide a reference index for diagnosing the depth of invasion and lymph node metastasis...
November 21, 2018: Oncology Reports
Kentaro Sato, Hitoshi Yamamura, Yoshiyuki Sakamoto, Hajime Morohashi, Takuya Miura, Toru Yoshikawa, Akiko Suto, Satoru Tsuruta, Kenichi Hakamada
BACKGROUND: Necrotizing fasciitis (NF) caused by colorectal cancer is rare, and very few cases associated with colon cancer have been reported. We describe the case of a patient with NF in the left thigh due to penetration of descending colon cancer who was treated with one-stage surgical resection without creating a stoma. CASE PRESENTATION: An 80-year-old woman was brought to our hospital complaining of fever and difficulty with body movement. A physical examination showed subcutaneous emphysema from the left lower abdomen to the left femoral region...
November 26, 2018: Surgical Case Reports
Koji Komori, Shin Fujita, Junki Mizusawa, Yukihide Kanemitsu, Masaaki Ito, Akio Shiomi, Masayuki Ohue, Mitsuyoshi Ota, Yoshihiro Akazai, Manabu Shiozawa, Takashi Yamaguchi, Hiroyuki Bandou, Kenji Katsumata, Yusuke Kinugasa, Yasumasa Takii, Takayuki Akasu, Yoshihiro Moriya
BACKGROUND: Mesorectal excision (ME) is the standard surgical procedure for lower rectal cancer. However, in Japan, total or tumor-specific ME with lateral pelvic lymph node dissection (LLND) is the standard surgical procedure for patients with clinical stages II or III lower rectal cancer, because lateral pelvic lymph node metastasis occasionally occurs in these patients. The aim of study was to elucidate the predictive factors of pathological lateral pelvic lymph node metastasis in patients without clinical lateral pelvic lymph node metastasis...
November 20, 2018: European Journal of Surgical Oncology
Xiaojun Zhou, Zhili Shan, Hengying Yang, Jingjing Xu, Wenjing Li, Feng Guo
Background: Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a critical role in the progression of diverse human malignancies. However, the significance of RelB in colorectal cancer (CRC) remains unclear. Here, we systematically explored the functions of the alternative NF-κB subunit RelB in colon cancer cells and its underlying mechanism...
2018: Cancer Cell International
Fuhong Zhang, Xiaowan Chen, Kehu Xi, Zhiqiang Qiu, Youhu Wang, Yan Gui, Yun Hou, Kangbing Chen, Xiaobing Zhang
Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopathologic and prognostic value of HOXD-AS1 in patients with malignant tumors. Materials and methods: Systematic literatures were searched from PubMed, Medline, Cochrane Library, Web of Science, EMBASE database, Ovid, Chinese CNKI, and the Chinese WanFang database...
2018: OncoTargets and Therapy
Qian Fei, Jianjia Xiao, Ling Gai, Jianwei Zhu
HMGB1-RAGE signaling plays an integral role in inflammation-driven carcinogenesis. In the present study, we showed that RAGE has direct association with K-Ras following HMGB1 exposure in colorectal cancer (CRC) cells. Immunofluorescence analysis revealed a significant co-localization between RAGE and K-Ras in HMGB1-exposed CRC cells. Moreover, we uncovered that HMGB1-mediated RAGE activation led to Yap1 accumulation in a Ras-dependent mechanism in CRC cells. HMGB1 activated the expression of Yap1 downstream stemness marker proteins CD44 and Sox2 in RAGE- and Ras-dependent manners...
November 19, 2018: Molecular Carcinogenesis
Marie Tauber, Romain Cohen, Pauline Laly, Laurence Josselin, Thierry André, Arsène Mekinian
Immune-related adverse events (irAEs), have been reported under immune checkpoint inhibitors. Nivolumab plus ipilimumab (N + I) demonstrated meaningful improvements in key patient-reported outcomes, in patients with pretreated microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). We report a case of severe necrotizing myositis which occurred in a patient treated with N + I combination for mCRC MSI-H. A 61-year-old woman was diagnosed with mCRC MSI-H and BRAFV600E mutated with synchronous liver, pleural, and lymph nodes metastases...
November 19, 2018: Clinical Rheumatology
Gjorgji Trajkovski, Ljubomir Ognjenovic, Zoran Karadzov, Gjorgji Jota, Dragan Hadzi-Manchev, Ognen Kostovski, Goce Volcevski, Vanja Trajkovska, Dafina Nikolova, Liljana Spasevska, Vesna Janevska, Vlado Janevski
BACKGROUND: Tumor-infiltrating lymphocytes (TIL) in tumour stroma are considered to be involved in the elimination of malignant cells and prevention of metastasis formation. TIL consist of T lymphocytes including cytotoxic lymphocytes that are a constituent part of the effector mechanism of anti-tumour immunity and B lymphocytes that can form tertiary lymphoid structures (TLS). TLS has been described in several solid tumours and colorectal carcinoma (CRC), and the influence on the local and systemic anti-cancer response...
October 25, 2018: Open Access Macedonian Journal of Medical Sciences
Dong Li, Xiaoyan Li, Genqu Li, Yan Meng, Yanghong Jin, Shuang Shang, Yanjie Li
AIMS: Colorectal Cancer (CRC) accounts for 6.1% incidence and 9.2% mortality worldwide. The current study aimed to investigate the effect of alpinumisoflavone (AIF) on CRC and its possible molecular mechanism. METHODS: HCT-116 and SW480 cells were chosen as cell model to study the anti-cancer activity of AIF in vitro experiments. Cells proliferative capacity and clonogenicity were examined by CCK-8 assay and colony formation assay, while cell apoptosis was detected by Hoechst 33258 staining and Flow cytometer...
November 15, 2018: Life Sciences
Jie Zhang, Yiwei Fu, Jiebin Chen, Qianjun Li, Huimin Guo, Bin Yang
BACKGROUND AND AIMS: Recent meta-analysis of genome-wide association studies (GWASs) identified a novel variant rs992157 at 2q35 that was associated with colorectal cancer (CRC) in the population of European ancestry. We aimed to replicate the association of rs992157 with CRC in the Chinese population and to further determine the real susceptible gene of CRC as indicated by this variant. METHODS: 824 CRC patients and 1063 healthy controls were included. The frequency of the genotype and the allele of rs992157 were compared between the patients and the controls and between different subgroups of patients classified by status of metastasis...
November 14, 2018: Clinics and Research in Hepatology and Gastroenterology
Wen-Yih Liang, Yu-Chen Wang, Chih-Yi Hsu, Shung-Haur Yang
Peritoneal involvement in colorectal cancer (CRC) has prognostic significance and is an important parameter in pathologic tumor staging. Restaging of tumors based on peritoneal elastic lamina invasion (ELI) has prognostic significance in CRCs classified as pathologic stage 3 tumors without regional lymph node metastasis (pT3N0). However, limited data are available on the significance of ELI in patients with node-positive disease. We applied elastic stain to one block per case for 141 consecutive patients with pT3N1M0 CRCs...
November 12, 2018: Human Pathology
Guo-Jun Tong, Gui-Yang Zhang, Jian Liu, Zhao-Zheng Zheng, Yan Chen, Ping-Ping Niu, Xu-Ting Xu
AIM: To analyze the survival trends in colorectal cancer (CRC) based on the different classifications recommended by the seventh and eighth editions of the American Joint Committee on Cancer staging system (AJCC-7th and AJCC-8th ). METHODS: The database from our institution was queried to identify patients with pathologically confirmed stage 0-IV CRC diagnosed between 2006 and 2012. Data from 2080 cases were collected and 1090 cases were evaluated through standardized inclusion and exclusion criteria...
November 10, 2018: World Journal of Clinical Oncology
X R Hu, C Xu, Y Kang, T Wang, Y Zhang, X H Yang
Objective: To investigate the expression of mismatch repair (MMR) proteins (MLH1, MSH2, MSH6 and PMS2) in colorectal cancers and to explore the relationship between MMR expression and clinicopathologic features. Methods: Six hundred and fifty-eight colon cancers were collected from January 2016 to January 2017 at Shengjing Hospital of China Medical University. Of the 658 patients there were 409 male and 249 female. The patients were 20 to 92 years old, with average age of (63±5) years old. Expression of MLH1, MSH2, MSH6 and PMS2 protein was detected by immunohistochemical method...
November 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Quan Qi, Yuefen Pan, Shuwen Han, Haihong Liao, Yizhen Jiang, Junjun Shen, Liping Zhong, Xian Wang, Jie Chen
Colorectal cancer (CRC) is one of the common human malignancies. Discovery and identification of novel therapeutic target is imperative to improve the prognosis of CRC patients. As a member of the PIM family, PIM3 has been found to be overexpressed in a variety of cancerous tumors. In this study, we evaluated the expression of PIM3 in CRC tissues and analyzed the role of PIM3 in CRC. Our results showed that PIM3 expression was significantly higher in CRC tissues compared with adjacent noncancerous tissues. The PIM3 expression level was found to be correlated with advanced disease stage and lymph node metastasis...
November 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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