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Lymph node metastasis colorectal

Ahmad Abdullah Madkhali, Sang-Hyun Shin, Ki Byung Song, Jae Hoon Lee, Dae Wook Hwang, Kwang Min Park, Young Joo Lee, Song Cheol Kim
The aim of the present study was to evaluate the short- and long-term outcomes of secondary metastasis to the pancreas in terms of overall survival (OS) and disease-free survival (DFS) after pancreatectomy.This retrospective study included 29 patients who underwent pancreatectomy for secondary metastasis to the pancreas between December 1995 and August 2016.The study group was divided into renal cell carcinoma (RCC) (17 patients) and non-RCC (12 patients). The non-RCC group had 5 cases of colorectal cancer and 7 of another primary origin...
October 2018: Medicine (Baltimore)
H Y Yang, C P Huang, M M Cao, Y F Wang, Y Liu
As a new kind of factors in regulating biological processes human cancers, long noncoding RNAs (lncRNAs) are attracting more and more attention from researchers. The lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE) is transcribed from chromosome 16 on the opposite strand to the neighboring IRX5 gene. It was originally discovered to be abnormally expressed in CRC and was certified to be critical biomarker in many cancers. However, its biological function and mechanism underlying the tumorigenesis of cervical cancer are still waiting for further exploration...
September 4, 2018: Neoplasma
Jia Qi, Chunhui Cui, Quanwen Deng, Lifeng Wang, Rihong Chen, Duanyang Zhai, Lang Xie, Jinlong Yu
Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide, and is difficult to detect in its early stages. Diagnostic and prognostic biomarkers are required, which may also be the basis for improving the targeted therapy for CRC. Sirtuin 6 (SIRT6) is a member of the sirtuin family of gene regulators, which have specific functions in genomic stability, gene transcription and energy metabolism in tumorigenesis. Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is a metabolic enzyme which can be deacetylated by sirtuins...
November 2018: Oncology Letters
Hongshan Zhang, Ping Jiang, Chuanrao Zhang, Siman Lee, Wei Wang, Hao Zou
Protease-activated receptor 4 (PAR4), a member of the G-protein-coupled receptor family, was previously identified to be involved in the progression of cancer. Previous study revealed that the expression of PAR4 was increased in colorectal cancer tissues compared with the associated normal tissues, particularly in positive lymph node and poorly differentiated types of cancer. We hypothesized that PAR4 serves a function in the progression of colorectal cancer. In the present study, overexpression of PAR4 in colorectal cancer LoVo cells promoted proliferation, anchorage-independent growth and migration...
November 2018: Oncology Letters
Li-Jun Wang, Zhong-Yi Zhang, Xiao-Luan Yan, Wei Yang, Kun Yan, Bao-Cai Xing
BACKGROUND: Liver resection is the first-line treatment for patients with resectable colorectal liver metastasis (CRLM), while radiofrequency ablation (RFA) can be used for small unresectable CRLM because of disease extent, poor anatomical location, or comorbidities. However, the long-term outcomes are unclear for RFA treatment in resectable CRLM. This study aimed to compare the recurrence rates and prognosis between resectable CRLM patients receiving either liver resection or RFA. METHODS: Consecutive patients who underwent RFA or hepatic resection from November 2010 to December 2015 were assigned in this retrospective study...
October 15, 2018: World Journal of Surgical Oncology
Li Liu, Huan Liu, Yangying Zhou, Jiaofeng He, Qiong Liu, Jian Wang, Manting Zeng, Dan Yuan, Fengbo Tan, Yuan Zhou, Haiping Pei, Hong Zhu
Helicase‑like transcription factor (HLTF) has been identified as a tumor suppressor gene. The hypermethylation of HTLF is frequently observed in various types of cancer, including colorectal cancer (CRC). However, the mechanisms through which HLTF suppresses CRC progression remain unclear. Thus, the aim of the present study was to explore the biological function of HLTF in CRC cells and the underlying mechanisms. CRC tissues and cells were used to detect the expression of HLTF. Wound‑healing and Transwell assays were performed to assess the motility of CRC cells...
October 10, 2018: International Journal of Oncology
Liang Huang, Hongcheng Lin, Liang Kang, Pinzhu Huang, Jun Huang, Jinlin Cai, Zhenyu Xian, Peixuan Zhu, Meijin Huang, Liping Wang, Cory J Xian, Jianping Wang, Jianghui Dong
Long noncoding RNAs (lncRNAs) play a critical role in the initiation and progression of colorectal cancer (CRC), but little is known about the function of lncRNAs in the colorectal liver metastasis (CLM). This study was designed to identify specific lncRNAs correlating to liver metastasis of CRC, and to further assess their clinical value. Seventeen patients with primary CRC lesions, adjacent normal mucosa, and synchronous liver metastases lesions were divided into discovery set (six patients) and test set (11 patients)...
October 14, 2018: Journal of Cellular Physiology
Ailin Qu, Yongmei Yang, Xin Zhang, Wenfei Wang, Yingjie Liu, Guixi Zheng, Lutao Du, Chuanxin Wang
BACKGROUND: Preoperative prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with colorectal cancer (CRC). In this study, we sought to develop and validate a non-invasive nomogram model to preoperatively predict LN metastasis in CRC. METHODS: Development of the nomogram entailed three subsequent stages with specific patient sets. In the discovery set (n = 20), LN-status-related miRNAs were screened from high-throughput sequencing data of human CRC serum samples...
October 9, 2018: EBioMedicine
Dehua Zhu, Jianping Zhou, Jinbo Zhao, Guiyang Jiang, Xiupeng Zhang, Yong Zhang, Ming Dong
ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snail, Cyclin D1, and Cyclin E1, and increased the expression of Occludin and Zo-1 through inactivating Ras-ERK signaling pathway. Furthermore, reduction of ZC3H13 associated with advanced TNM stage (p = 0...
October 12, 2018: Journal of Cellular Physiology
Eon Chul Han, Yoon-Hye Kwon, Kyu Joo Park, Seung-Yong Jeong, Sung-Bum Kang, Jae Hwan Oh, Seung Chul Heo
Purpose: Although lymph node (LN) metastasis is an important prognostic marker of colorectal cancer (CRC), the effect of LN metastasis on the survival of stage IV CRC is debated yet. Methods: LN status and survivals as well as clinicopathological features of synchronous stage IV CRC patients, operated for 8 years, were analyzed. Patients with hematogenous metastases were included only but those with peritoneal seeding or preoperative adjuvant therapy were not included...
October 2018: Annals of Surgical Treatment and Research
Guojun Tong, Wei Xu, Guiyang Zhang, Jian Liu, Zhaozheng Zheng, Yan Chen, Pingping Niu, Xuting Xu
PURPOSE: Tissue carcinoembryonic antigen (t-CEA) and serum carcinoembryonic antigen (s-CEA) expression profiles are the most useful tumor markers for the diagnosis and evaluation of colorectal cancer (CRC) worldwide; however, their roles in CRC progression remain controversial. This study aimed to compare the prognostic values of both s-CEA and t-CEA in CRC. METHODS: A total of 517 patients from January 2006 to December 2010 with stages I-III CRC were retrospectively examined, with 5-year postoperative follow-up and death as end-points...
October 9, 2018: Cancer Medicine
Ignasi Puig, María López-Cerón, Anna Arnau, Òria Rosiñol, Miriam Cuatrecasas, Alberto Herreros-de-Tejada, Ángel Ferrández, Miquel Serra-Burriel, Óscar Nogales, Francesc Vida, Luisa de Castro, Jorge López-Vicente, Pablo Vega, Marco A Álvarez-González, Jesús González-Santiago, Marta Hernández-Conde, Pilar Díez-Redondo, Liseth Rivero Sánchez, Antonio Z Gimeno-García, Aurora Burgos, Francisco Javier García-Alonso, Marco Bustamante-Balén, Eva Martínez-Bauer, Beatriz Peñas, Maria Pellise
BACKGROUND & AIMS: T1 colorectal polyps with at least 1 risk factor for metastasis to lymph node should be treated surgically and are considered endoscopically unresectable. Optical analysis, based on the narrow-band imaging international colorectal endoscopic (NICE) classification system, is used to identify neoplasias with invasion of the submucosa that require endoscopic treatment. We assessed the accuracy of the NICE classification, along with other morphologic characteristics, in identifying invasive polys that are endoscopically unresectable (have at least 1 risk factor for metastasis to lymph node)...
October 5, 2018: Gastroenterology
W Zheng, L Zhang, Y L Wu, H Z Zhang
Objective: To evaluate the prognostic value of lymph node metastasis-related indexes in patients with stage N2b colorectal cancer. Methods: Clinicopathologic data of 245 patients with stage N2b colorectal cancer who initially underwent radical operation in Cancer Hospital, Chinese Academy of Medical Sciences between January 2007 and December 2012 were retrospectively analyzed. The prognostic values of several indexes, including number of positive lymph nodes, number of negative lymph nodes, lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) were analyzed...
September 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
X F Wang, X L Zhang, L P Xu, G G Shi, H Y Zheng, B C Sun
Objective: To investigate the relationship between the expression of stem cell markers CD44 and Lgr5 and the clinicopathological features, lymph node and liver metastasis, and to analyse the value of both in evaluating the prognosis of colorectal cancer. Methods: A total of 90 cases of colorectal cancer, 20 cases of adjacent tissues, 30 cases of lymph node metastases, 28 cases of cancer nodules and 30 cases of liver metastasis of colorectal cancer were collected from Department of Pathology of the Second Hospital of Tianjin Medical University from January 2011 to June 2016...
September 25, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Abdullah Alsuhaibani, Ahmed Elashwah, Abdullah Alkafi, Camelia Constantinescus, Faisal ALzorkany
OBJECTIVES: We retrospectively evaluate local control rate at 6 months and 1 year in oligometastatic cancer patients treated with SBRT using CyberKnife. METHODS: Total of 21 patients with 24 treatment sites from February 2014 till June 2017 who were treated with SBRT in our institution were included in this study. RESULTS: Eleven patients were males, 10 patients were females, median age at diagnosis was 63 years, and colorectal cancer is the most commonly diagnosed cancer in 18 patients...
October 6, 2018: Journal of Gastrointestinal Cancer
Chang-Feng Li, Yong-Chao Li, Yun Wang, Li-Bo Sun
BACKGROUND/AIMS: Since the combined actions of lncRNAs and miRNAs have been considered to be involved in the occurrence and development of various neoplasms, the main purpose of this study was to discover whether and how lncRNA H19 and miR-194 influenced the epithelial-mesenchymal transition (EMT) process of colorectal adenocarcinoma (CRA). METHODS: Totally 214 pairs of CRA and adjacent normal tissues were collected, and 5 human CRA cell lines (i.e. HCT116, HT-29, RKO SW280 and Lovo) were purchased...
October 2, 2018: Cellular Physiology and Biochemistry
Eiji Shinto, Jin-Ichi Hida, Hideyuki Ike, Hirotoshi Kobayashi, Yojiro Hashiguchi, Kazuo Hase, Hideki Ueno, Kenichi Sugihara
BACKGROUND: Complete mesocolic excision is becoming popular in colon cancer surgery in Western countries, and in the tumor-node-metastasis (TNM) classification of rectal cancer, a part of the lateral pelvic lymph nodes is classified as regional. However, the appropriateness of TNM staging according to the assessment of nodal status exclusively by extended lymphadenectomy remains unclear. PATIENTS AND METHODS: Using a nationwide multicenter database in Japan, we retrospectively analyzed 6866 patients with stage III colorectal cancer (CRC) treated with extended (D3) dissection...
October 1, 2018: Annals of Surgical Oncology
H-S Hofmann, C Doblinger, T Szöke, C Grosser, T Potzger, M Ried, R Neu
BACKGROUND: The lungs are the second most common organ site for metastases in patients with colorectal cancer (CRC). Lymph node metastasis of CRC represents a prognostic factor for survival. OBJECTIVE: The present study investigated the influence of CRC lymph node metastasis on lung metastasis, in particular thoracic lymph node metastasis. MATERIAL AND METHODS: A retrospective analysis of 88 patients (n = 56 male) with curative resection of lung metastases of CRC was performed...
October 1, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Manuel Neves, Rita Azevedo, Luís Lima, Marta I Oliveira, Andreia Peixoto, Dylan Ferreira, Janine Soares, Elisabete Fernandes, Cristiana Gaiteiro, Carlos Palmeira, Sofia Cotton, Stefan Mereiter, Diana Campos, Luís Pedro Afonso, Ricardo Ribeiro, Avelino Fraga, Ana Tavares, Hélder Mansinho, Eurico Monteiro, Paula A Videira, Paulo P Freitas, Celso A Reis, Lúcio Lara Santos, Lorena Dieguez, José Alexandre Ferreira
Circulating tumour cells (CTCs) originating from a primary tumour, lymph nodes and distant metastases hold great potential for liquid biopsies by providing a molecular fingerprint for disease dissemination and its temporal evolution through the course of disease management. CTC enumeration, classically defined on the basis of surface expression of Epithelial Cell Adhesion Molecule (EpCAM) and absence of the pan-leukocyte marker CD45, has been shown to correlate with clinical outcome. However, existing approaches introduce bias into the subsets of captured CTCs, which may exclude biologically and clinically relevant subpopulations...
September 28, 2018: New Biotechnology
Yukio Abe, Yoshifumi Nakayama, Takefumi Katsuki, Yuzuru Inoue, Noritaka Minagawa, Takayuki Torigoe, Aiichiro Higure, Tatsuhiko Sako, Naoki Nagata, Keiji Hirata
AIM: Monocarboxylate transporter 4 (MCT4) is a proton pump that exchanges lactate through the plasma membrane. The present study investigated the clinical significance of the expression of MCT4 in patients with right- or left-sided colorectal cancer (CRC). METHODS: Surgical specimens from 237 CRC patients were immunohistochemically stained with polyclonal anti-MCT4 antibodies. The relationships among the MCT4 expression, the clinicopathological factors, and the prognosis were evaluated...
September 30, 2018: Asia-Pacific Journal of Clinical Oncology
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