Bárbara P N Assis, Ana T Chaves, Daniela P Lage, Mariana M Cardoso, Camila S Freitas, Isabela A G Pereira, Raquel S B Câmara, Vívian T Martins, Ana Laura G de Oliveira, Ricardo A Machado-de-Ávila, Alexsandro S Galdino, Miguel A Chávez-Fumagalli, Myron Christodoulides, Denise U Gonçalves, Lílian L Bueno, Ricardo T Fujiwara, Eduardo A F Coelho, Manoel O da Costa Rocha
Leprosy diagnosis is difficult due to the clinical similarity with other infectious diseases, and laboratory tests presents problems related to sensitivity and/or specificity. In this study, we used bioinformatics to assess Mycobacterium leprae proteins and formulated a chimeric protein that was tested as a diagnostic marker for the disease. The amino acid sequences from ML0008, ML0126, ML0308, ML1057, ML2028, ML2038, ML2498 proteins were evaluated, and the B-cell epitopes QASVAYPATSYADFRAHNHWWNGP, SLQRSISPNSYNTARVDP and QLLGQTADVAGAAKSGPVQPMGDRGSVSPVGQ were considered M...
March 30, 2024: Tuberculosis