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Isabela Bispo Santos da Silva Costa, André Neder Ramires Abdo, Cristina Salvadori Bittar, Silvia Moulin Ribeiro Fonseca, Aline Sabrina Holanda Teixeira Moraes, Roberto Kalil Filho, Juliana Pereira, Ludhmila Abrahão Hajjar
Erdheim-Chester Disease is a rare entity, classified as an inflammatory myeloid neoplasm, with an unknown incidence, occurring preferentially in men after 50 years of age. Classically, it has a multisystemic presentation, with the skeletal system being the most frequently affected (90% of the patients), followed by genitourinary involvement in 60% of cases and central nervous system in the pituitary and diabetes insipidus in 25% of the cases. Cardiovascular manifestations are present in more than half of the patients, with aortic infiltration and atrial pseudotumor being the most common forms...
December 2018: Arquivos Brasileiros de Cardiologia
Eduarda da Costa Marinho, Isis Danyelle Dias Custódio, Isabela Borges Ferreira, Cibele Aparecida Crispim, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
OBJECTIVE: To correlate the perceptions related to dietary intake with the domains and subscales of health-related quality of life (HRQL) in women with breast neoplasms receiving chemotherapy. METHODS: In this prospective study, 55 women with breast cancer were followed up during chemotherapy at three different times (T0, T1, T2). Before chemotherapy, perceptions related to food consumption were evaluated. HRQL was analyzed with the EORTC QLQ-C30 and Br23 instruments 21 days after each investigated cycle...
November 29, 2018: Clinics
Isabela C F Vasques, Jaime W V de Mello, Renato W Veloso, Vanessa de P Ferreira, Walter A P Abrahão
Coprecipitation of Fe and Al (hydr)oxides has been considered a low-cost process to remove As from wastewater. Arsenate is the most stable form of As in aerobic environments such as surface water, soils, and sediments and can be removed from water through methods based on this process. Iron/aluminum molar ratios of 100:0, 80:20, and 60:40 were used to treat water contaminated with As at concentrations of 50 and 500 mg L. Aluminum, ferrous, and ferric sulfates were used to coprecipitate Al and Fe (hydr)oxides at high pH...
November 2018: Journal of Environmental Quality
Isabela Tiemy Pereira, Lucia Spangenberg, Anny Waloski Robert, Rocío Amorín, Marco Augusto Stimamiglio, Hugo Naya, Bruno Dallagiovanna
The regulation of gene expression acts at numerous complementary levels to control and refine protein abundance. The analysis of mRNAs associated with polysomes, called polysome profiling, has been used to investigate the post-transcriptional mechanisms that are involved in different biological processes. Pluripotent stem cells are able to differentiate into a variety of cell lineages, and the cell commitment progression is carefully orchestrated. Genome-wide expression profiling has provided the possibility to investigate transcriptional changes during cardiomyogenesis; however, a more accurate study regarding post-transcriptional regulation is required...
December 4, 2018: Scientific Data
Jaqueline Dos Santos, Isabela Galarda Varassin, Valéria Cunha Muschner
The data are supporting the research article "Effects of neighborhood on pollination and seed dispersal of a threatened palm" (Santos et al., 2018). We recorded through focal observation mutualistic interactions with floral and frugivorous visitors and 11 individuals of the threatened Euterpe edulis palm in Brazil. We thus provide two datasets, one about interactions with floral visitors (Pollination data.xlsx) and other about interactions with frugivorous visitors (Seed dispersal data.xlsx). Both datasets are structured in eight spreadsheets: Two about observed interactions among Euterpe edulis palm and floral and frugivorous visitors; two response variables (frequency and assembly composition); four predictor variables (conspecific aggregation, basal area, number of rachillae/fruits, flower in anthesis/ripe fruits)...
December 2018: Data in Brief
Brian M Osman, Isabela C Saba, William A Watson
The purpose of this case report is to increase awareness that a diagnosis of malignant hyperthermia may have long-lasting or permanent effects on a patient's insurance eligibility or premiums despite legislation providing varying levels of protection from preexisting conditions or genetic discrimination. We present a case of severe rigors, unexplained severe metabolic acidosis, and severe hyperthermia in a patient after general anesthesia for extensive head and neck surgery. The patient was treated for malignant hyperthermia and demonstrated a significant clinical improvement with the administration of dantrolene...
2018: Case Reports in Anesthesiology
Rudy Parrado, Juan Carlos Ramirez, Anabelle de la Barra, Cristina Alonso-Vega, Natalia Juiz, Lourdes Ortiz, Daniel Illanes, Faustino Torrico, Joaquim Gascon, Fabiana Alves, Laurence Flevaud, Lineth Garcia, Alejandro G Schijman, Isabela Ribeiro
This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time PCR (qPCR) for baseline detection and quantification of parasitic loads and post-treatment identification of failure in the context of clinical trials for treatment of chronic Chagas disease, namely DNDi-CH-E1224-001 (NCT01489228) and MSF-DNDi PCR sampling optimization study (NCT01678599). Patients from Cochabamba (N= 294), Tarija (N= 257), and Aiquile (N= 220) were enrolled. Three serial blood samples were collected at each time-point and qPCR triplicates were tested per sample...
December 3, 2018: Antimicrobial Agents and Chemotherapy
Rodrigo Nunes Rodrigues-da-Silva, Daniely Correa-Moreira, Isabela Ferreira Soares, Paula Melo de-Luca, Paulo Renato Rivas Totino, Fernanda Nazaré Morgado, Maria das Graças de Oliveira Henriques, André Luis Peixoto Candea, Balwan Singh, Mary R Galinski, Alberto Moreno, Joseli Oliveira-Ferreira, Josué da Costa Lima-Junior
Plasmodium vivax Merozoite Surface Protein-9 (PvMSP-9) is a malaria vaccine candidate naturally immunogenic in humans and able to induce high antibody titers in animals when delivered as a recombinant protein. Recently, we identified the sequence EAAPENAEPVHENA (PvMSP9E795-A808 ) as the main linear B-cell epitope in naturally exposed individuals. However, the potential of PvMSP9E795-A808 as an immunogen in experimental animal models remained unexplored. Here we assess the immunogenicity of PvMSP9E795-A808 using synthetic peptides...
November 30, 2018: Vaccine
Amanda Figueiredo, Isabela Cabeça Agnolon, Louyse Gabrielli Lopes, Rodrigo Giglioti, Ana Carolina de Souza Chagas
Reproductive parameters of Rhipicephalus (Boophilus) microplus are often evaluated. They are good indicators of resistance to commercial acaricides and of plant extracts' efficacy. The objective of this study was to compare the techniques: visual estimation and quantification by sampling used in the Adult Immersion Test (AIT) to calculate the hatching rate of eggs. Engorged females collected from cattle were subjected to the AIT with plant extracts and kept in an incubator for oviposition. The egg hatching was evaluated in 210 syringes by visual estimation (%)...
December 15, 2018: Veterinary Parasitology
Rodrigo S C Cabral, Cassia C F Alves, Hellen R F Batista, Wendel C Sousa, Isabela S Abrahão, Antônio E M Crotti, Mariana B Santiago, Carlos H G Martins, Mayker L D Miranda
In Brazilian folk medicine, Protium heptaphyllum is used to treat inflammatory conditions and to hasten wound repair. This paper aims to investigate the chemical composition and the in vitro antibacterial effects of the essential oils (EOs) obtained from P. heptaphyllum leaves and ripe and unripe fruits against a representative panel of oral pathogens. The GC-FID and GC-MS analysis revealed that the major components determined in P. heptaphyllum essential oils were myrcene (59.0%), β-elemene (17.2%), limonene (12...
November 30, 2018: Natural Product Research
Ana Carolina Guidorizzi Zanetti, Kelly Graziani Giacchero Vedana, Camila Corrêa Matias Pereira, João Mazzoncini de Azevedo Marques, Amanda Heloisa Santana da Silva, Isabela Dos Santos Martin, Rosana Aparecida Spadoti Dantas, Jacqueline de Souza, Sueli Aparecida Frari Galera, Edilaine Cristina da Silva Gherardi-Donato
BACKGROUND: Families are the main caregivers of people with schizophrenia. Family dynamic and expressed emotion (EE) of relatives are fundamental determinants on the course of schizophrenia. METHOD: This study analyzed socio-demographic and clinical factors related to EE components. A total of 94 dyads (patients with schizophrenia and their relatives) were recruited from three mental health clinics. A form containing socio-demographic and clinical variables and the Brazilian version of Family Questionnaire were used and the data were analyzed through regression model...
November 29, 2018: International Journal of Social Psychiatry
Walter A Eyer-Silva, Marcelo Costa Velho Mendes de Azevedo, Guilherme Almeida Rosa da Silva, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Isabela Vieira do Lago, Franciele Cristina Ferreira Pereira, Miriã Boaretto Teixeira Fernandes, Maria Helena Galdino Figueiredo-Carvalho, Vanessa Brito de Souza Rabello, Rosely Maria Zancopé-Oliveira, Rodrigo de Almeida-Paes, Fernando Raphael de Almeida Ferry, Rogério Neves-Motta
Sporotrichosis is a human and animal disease caused by dimorphic pathogenic species of the genus Sporothrix . We report a dramatic presentation of Sporothrix brasiliensis infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Sporotrichosis remains a neglected opportunistic infection in patients with AIDS and awareness of this potentially fatal infection is of utmost importance.
March 2019: Medical Mycology Case Reports
Isabela P Ceravolo, Carlos L Zani, Flávio J B Figueiredo, Markus Kohlhoff, Antônio E G Santana, Antoniana U Krettli
BACKGROUND: Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflammatory. Its fractionated extracts were assayed in vitro for activity against malaria parasites and for cytotoxicity. METHODS: Aspidosperma pyrifolium activity was evaluated against Plasmodium falciparum using extracts in vitro. Toxicity towards human hepatoma cells, monkey kidney cells or human monocytes freshly isolated from peripheral blood was also assessed...
November 26, 2018: Malaria Journal
Tamara Kerber Tedesco, Thais Gimenez, Isabela Floriano, Anelise Fernandes Montagner, Lucila Basto Camargo, Ana Flávia Bissoto Calvo, Susana Morimoto, Daniela Prócida Raggio
BACKGROUND: A systematic quantitative evaluation of the available evidence of the treatment for caries lesions in primary teeth that considers how different caries progressions lead to the need for distinct interventions might provide additional useful information for clinical evidence-based decision making. The aim of this systematic review and network meta-analysis was to verify the effect of the treatments on caries lesion arrestment (CLA) or the success rate (SR) of dentin caries lesion treatments in the primary teeth...
2018: PloS One
Aniek Wols, Anna Lichtwarck-Aschoff, Elke A Schoneveld, Isabela Granic
Anxiety disorder is the most prevalent and frequently diagnosed disorder in youth, and associated with serious negative health outcomes. Our most effective prevention programs, however, have several limitations. These limitations can be addressed using game-based interventions. Results from two randomized controlled trials on the video game MindLight show improvements in anxiety that are maintained up to 6 months. The game was designed based on evidence-based therapeutic techniques; however, it is unclear if children's engagement with these techniques actually predict improvements in anxiety symptoms...
2018: Journal of Psychopathology and Behavioral Assessment
Alessandra Vl Quidim, Tatiana C Bruno, Paola Caroline Lacerda Leocádio, Penélope Lacrísio Dos Reis Menta, Jacqueline Isaura Alvarez-Leite, Itamar S Santos, Paulo A Lotufo, Isabela M Benseñor, Alessandra C Goulart
AIM: We aimed to analyze the influence of myeloperoxidase (MPO) activity on mortality in the Acute Coronary Syndrome Registry Strategy (ERICO) study. METHODS: MPO activity levels were evaluated in 342 patients. We performed survival analyses using Kaplan-Meier curves and Cox regression with respective hazard ratios, 95% CI, according to MPO tertiles distribution up to 7 years of follow-up. RESULTS: Higher MPO activity levels were seen in men, smokers, diabetics and those who were taking aspirin...
November 20, 2018: Biomarkers in Medicine
Mayara Rodrigues Brandão De Paiva, Nayara Almeida Lage, Maria Carolina Andrade Guerra, Marcos Paulo Gomes Mol, Marcela Coelho Silva Ribeiro, Gustavo De Oliveira Fulgêncio, Dawidson A Gomes, Isabela Da Costa César, Sílvia Ligório Fialho, Armando Silva-Cunha
PURPOSE: To assess the in vivo release profile and the retinal toxicity of a poly (lactic-co-glycolic acid) (PLGA) sustained-release sirolimus (SRL) intravitreal implant in normal rabbit eyes. METHODS: PLGA intravitreal implants containing or not SRL were prepared, and the viability of ARPE-19 and hES-RPE human retinal cell lines was examined after 24 and 72 h of exposure to implants. New Zealand rabbits were randomly divided into two groups that received intravitreal implants containing or not SRL...
November 19, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
João Soares Felício, Lilian de Souza d'Albuquerque Silva, Carlliane Lima E Lins Pinto Martins, João Felício Abrahão Neto, Manuela Nascimento de Lemos, Fabrício de Souza Resende, Wanderson Maia da Silva, Angélica Leite de Alcântara, Maria Clara Neres Iunes de Oliveira, Norberto Jorge Kzan de Souza Neto, Isabela Imbelloni Farias de Franco, Nathalie Abdallah Zahalan, Luísa Correa Janaú, Ana Carolina Contente Braga de Souza, Flavia Marques Santos, Natércia Neves Marques de Queiroz, Neyla Arroyo Lara Mourão, Márcia Costa Dos Santos, Karem Miléo Felício, Franciane Trindade Cunha de Melo
Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoacoustic emissions (OAEs) is useful to identify subclinical cochlear dysfunction. Therefore, the aim of this study was to evaluate the association between abnormal OAEs responses, diabetic kidney disease (DKD) and diabetic cardiac autonomic neuropathy (CAN). We performed a cross-sectional study with 37 type 1 DM patients without auditory symptoms, submitted to the study of Distortion Product Otoacoustic Emissions (DPOAEs) and screened for DKD and CAN...
2018: Diabetology & Metabolic Syndrome
Doreen N Palsgrove, Diana Taheri, Simeon U Springer, Morgan Cowan, Gunes Guner, Maria A Mendoza Rodriguez, Maria Del Carmen Rodriguez Pena, Yuxuan Wang, Isaac Kinde, Bernardo F P Ricardo, Isabela Cunha, Kazutoshi Fujita, Dilek Ertoy, Kenneth W Kinzler, Trinity J Bivalacqua, Nickolas Papadopoulos, Bert Vogelstein, George J Netto
Activating mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the most common genetic alterations in urothelial carcinoma (UC) of the bladder and upper urinary tract. While the cadherin 1 (CDH1) gene is commonly mutated in the clinically aggressive plasmacytoid variant of urothelial carcinoma (PUC), little is known about their TERT promoter mutation status. A retrospective search of our archives for PUC and UC with plasmacytoid and/or signet ring cell features (2007-2014) was performed...
November 14, 2018: Human Pathology
Walter Henriques da Costa, Aline Fusco Fares, Stephania M Bezerra, Mariana A Morini, Ligia Alencar de Toledo Benigno, Diego Abreu Clavijo, Lucas Fornazieri, Maurício Murce Rocha, Isabela Werneck da Cunha, Stenio de Cassio Zequi
PURPOSE: To evaluate the prognostic impact of the protein expression of both PBRM1 and BAP1 in metastatic tissue of patients with metastatic clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS: In all 124 consecutive cases of metastatic ccRCC, who underwent metastasectomy or biopsy of metastatic tumor tissue between 2007 and 2016 were selected from the medical records of our institution. Additionally, 38 paired cases with tissue from the primary tumor involving radical or partial nephrectomy for ccRCC were also selected...
November 13, 2018: Urologic Oncology
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