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Daniel Beltrame Ferreira, Walter Henriques da Costa, Diego Abreu Clavijo, Ricardo Decia, Isabela Werneck Cunha, Luciana Schultz, Rafael Malagoli Rocha, Gustavo Cardoso Guimarães, Stênio de Cássio Zequi
Objective: To evaluate immunohistochemical erythropoietin (EPO) expression in clear cell renal cell carcinoma (ccRCC), its association with major clinicopathological variables and its prognostic impact. Methods: A total of 220 patients with renal cell carcinoma (RCC) surgically treated between 1989 and 2009 were evaluated in this multi-institutional study. All the cases were reviewed by a single pathologist and the immunohistochemical reactivity to EPO was analysed using tissue microarray...
November 27, 2017: Kidney cancer
Aline Dionizio, Heloisa Aparecida Barbosa Silva Pereira, Tamara Teodoro Araujo, Isabela Tomazini Sabino-Arias, Mileni Silva Fernandes, Karina Aparecida Oliveira, Fabielle Sales Raymundo, Tânia Mary Cestari, Fernando Neves Nogueira, Rui Albuquerque Carvalho, Marília Afonso Rabelo Buzalaf
The effect of duration of chronic treatment with fluoride (F, 50 mg/L as NaF) on the lipid profile, lipid droplets and triglycerides (TG) in liver was evaluated in mice with nonalcoholic fatty liver disease (NAFLD) previously induced by hyperlipidic diet and in animals fed normocaloric diet. In addition, the effect of F administered for a short period (20 days) was evaluated on de novo lipogenesis, by nuclear magnetic resonance. GRP78, Apo-E, and sterol regulatory element-binding protein (SREBP) were quantified by Western blotting...
October 16, 2018: Biological Trace Element Research
Isabela Solar, Larissa Ariel Oliveira Santos, Luciana Miyuki Yamashita, Jacqueline S Barret, Cristiane Kibune Nagasako, Ciro Garcia Montes, Marcela Lanzoni Louzada, Marcela Silva Calsa, Ana Carolina Junqueira Vasques
This study investigated the association between fermentable oligo-di-mono-saccharides and polyols (FODMAPs) intake, problematic foods, body adiposity, and gastrointestinal symptoms in 44 women with irritable bowel syndrome (IBS). Around 84% reported to have excluded some food from their diet. Adiposity was not associated with the frequency of gastrointestinal symptoms and IBS severity. Controlling for BMI, there were significant correlations between number of problematic foods versus waist circumference (r = 0...
October 16, 2018: European Journal of Clinical Nutrition
Gabriel E Ramos-Tafur
A new species of caridean shrimp of the family Alpheidae, Automate isabelae sp. nov., found in stomach analysis contents of the lane snapper Lutjanus synagris (Linnaeus, 1758), from the Keys and SW coast of Florida, Gulf of Mexico, is described. The abdomen and portions of the cephalic appendages were damaged in holotype, but remainder of the body and the chelipeds, whith the most important diagnostic characters are in decent or perfect condition, the description was further supplemented based on intact morphological parts of the paratypes...
July 17, 2018: Zootaxa
Isabela C Rocha, Wagner Rafael M Souza
Although the world species diversity of Marilia Müller 1880 is not great, knowledge about this group may be underestimated, since several areas are poorly studied, especially in Northeast Region, Brazil. Two new species are described and illustrated here based on specimens collected in Maranhão State, from which the genus has not been reported previously. Despite the similarity of Marilia caramuru sp. nov. with M. elongata Martynov 1912, differences between them are observed especially in segment X and preanal appendages, in addition to details of wing venation...
May 30, 2018: Zootaxa
Leticia Lopes Quirino Pantoja, Isabela Porto de Toledo, Yasmine Mendes Pupo, André Luís Porporatti, Graziela De Luca Canto, Liete Figueiredo Zwir, Eliete Neves Silva Guerra
OBJECTIVES: The purpose of this systematic review was to evaluate evidence about the prevalence of degenerative joint disease (DJD) of the temporomandibular joints (TMJ). MATERIALS AND METHODS: We performed search on electronic databases and gray literature from their inception to January 2018. Studies reporting prevalence data of DJD on TMJ were included. DJD was assessed through clinical and imaging diagnosis. Studies risk of bias was evaluated using the Critical Appraisal Checklist for Studies Reporting Prevalence Data...
October 11, 2018: Clinical Oral Investigations
Sarah L Paralovo, Cybelli G G Barbosa, Isabela P S Carneiro, Priscila Kurzlop, Guilherme C Borillo, Maria Fernanda C Schiochet, Ana Flavia L Godoi, Carlos I Yamamoto, Rodrigo A F de Souza, Rita V Andreoli, Igor O Ribeiro, Antonio O Manzi, Ivan Kourtchev, Jose Oscar V Bustillos, Scot T Martin, Ricardo H M Godoi
This research aims to assess air quality in a transitional location between city and forest in the Amazon region. Located downwind of the Manaus metropolitan region, this study is part of the large-scale experiment GoAmazon2014/5. Based on their pollutant potential, inhalable particulate matter (PM2.5 ), nitrogen dioxide (NO2 ), sulfur dioxide (SO2 ), ozone (O3 ), hydrogen sulfide (H2 S), benzene, toluene, ethylbenzene and meta-, orto-, para-xylene (BTEX) were selected for analysis. Sampling took place during the wet season (March-April 2014) and dry season (August-October 2014)...
February 10, 2019: Science of the Total Environment
Ivani Rodrigues Glass, Allan Dantas Dos Santos, Ana Elisabeth Leal Varjão, Isabela Soares Costa, Dalmo Correia, Ângela Maria Silva
INTRODUCTION: We evaluated clinical and epidemiological characteristics of Trypanosoma cruzi infection in Sergipe. METHODS: In this cross-sectional study, we collected serum samples to identify serological markers of Chagas disease. A questionnaire was used, and electrocardiogram, echocardiogram, chest radiography, and contrast radiography of esophagus and colon were performed. RESULTS: T. cruzi infection seroprevalence was 12.1%, mean age of subjects was 55 years, 90% had an elementary school education, 78...
September 2018: Revista da Sociedade Brasileira de Medicina Tropical
Isabela de Lucena Heráclio, Maysa Almeida da Silva, Mirella Bezerra Rodrigues Vilela, Conceição Maria de Oliveira, Paulo Germano de Frias, Cristine Vieira do Bonfim
OBJECTIVE: to evaluate the completeness of perinatal death investigation sheets, stratified by age components. METHOD: descriptive study carried out in Recife, PE, in 2014. Among 308 perinatal deaths, 46 were excluded from this study due to association with congenital malformations, and 7 due to missing investigation sheets. Analysis included 255 deaths (160 fetal deaths, and 95 preterm neonatal deaths). The degree of completeness of 98 variables was calculated...
September 2018: Revista Brasileira de Enfermagem
Fernando Madalena Volpe, Isabela Pinto Braga, Eliane Mussel da Silva
INTRODUCTION: The readmission phenomenon in psychiatry not only reflects the severity and chronicity of the underlying disorders, but also indicates the quality of mental healthcare. In the context of the Brazilian mental healthcare reform, no study has included the availability of outpatient care among the potential determinants for psychiatric readmission. OBJECTIVE: To correlate the availability of community healthcare resources at the place of residence with the risk of psychiatric readmission...
July 2018: Trends in Psychiatry and Psychotherapy
Koichi R Katsumura, Charu Mehta, Kyle J Hewitt, Alexandra A Soukup, Isabela Fraga de Andrade, Erik A Ranheim, Kirby D Johnson, Emery H Bresnick
By inducing the generation and function of hematopoietic stem and progenitor cells, the master regulator of hematopoiesis GATA-2 controls the production of all blood cell types. Heterozygous GATA2 mutations cause immunodeficiency, myelodysplastic syndrome, and acute myeloid leukemia. GATA2 disease mutations commonly disrupt amino acid residues that mediate DNA binding or cis -elements within a vital GATA2 intronic enhancer, suggesting a haploinsufficiency mechanism of pathogenesis. Mutations also occur in GATA2 coding regions distinct from the DNA-binding carboxyl-terminal zinc finger (C-finger), including the amino-terminal zinc finger (N-finger), and N-finger function is not established...
October 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
Douglas B Craig, Jennifer R Lischynski, Isabela C C Cardoso
A sensitive assay for citrate was developed. Citrate was incubated with 50 μM Eu3+ -tetracycline and the complex separated using capillary electrophoresis utilizing post-column laser-induced luminescence detection in a sheath flow cuvette. Signal was linear with citrate concentration from 10 μM to 200 nM. Injection volumes were 320 pL. For the 200 nM sample, this corresponds to the injection of 64 amoles of citrate. Separation time was < 90 s with a total run time of 5 min. As an application the method was used to analyze citrate in agricultural and medicinal products...
October 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Marilu Constantino Max, Camila Bizarro-Silva, Isabela Búfalo, Suellen Miguez González, Andressa Guidugli Lindquist, Roberta Garbelini Gomes, Thales Ricardo Rigo Barreiros, Lívia Aires Lisboa, Fábio Morotti, Marcelo Marcondes Seneda
Folliculogenesis is a process of development and maturation of the ovarian follicles, being essential for the maintenance of fertility. In in vivo conditions, 99.9% of the follicles of an ovary do not ovulate and undergo atresia. In order to minimize this loss and to clarify the existing mechanisms, a technique was developed that allows for the in vitro follicular development. The objective of this study was to evaluate the effects of different epidermal growth factor (EGF) concentrations on the in vitro culturing of equine preantral follicles...
October 3, 2018: In Vitro Cellular & Developmental Biology. Animal
Arie Carneiro, Álan Roger Gomes Barbosa, Lucas Seiti Takemura, Paulo Priante Kayano, Natasha Kouvaleski Saviano Moran, Carolina Ko Chen, Marcelo Langer Wroclawski, Gustavo Caserta Lemos, Isabela Werneck da Cunha, Marcos Takeo Obara, Marcos Tobias-Machado, Adam G Sowalsky, Bianca Bianco
Background: Prostate cancer (PCa) is a heterogeneous disease that lends itself toward numerous therapeutic options depending on its risk stratification. One of the greatest challenges in PCa urologic practice is to select patients who should be referred for biopsy and, for those patients who are diagnosed with cancer, to differentiate between patients with indolent disease from those with an unfavorable prognosis and, to determine ideal patient management and avoid unnecessary interventions. Accordingly, there is a growing body of literature reporting immunohistochemical studies with the objective of determining a prostate cancer prognosis...
2018: Frontiers in Oncology
Dyego José de Araújo Brito, Elisangela Milhomem Dos Santos, Raimunda Sheyla Carneiro Dias, Isabela Leal Calado, Gyl Eanes Barros Silva, Joyce Santos Lages, Francisco das Chagas Monteiro Júnior, Alcione Miranda Dos Santos, Natalino Salgado Filho
Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine and cystatin C and (2) Albuminuria (ACR ≥30 mg/g)...
November 2018: Renal Failure
Danilo César Galindo Bedor, Noely Camila Tavares Cavalcanti Bedor, José Wellithom Viturino da Silva, Giovana Damasceno Sousa, Davi Pereira de Santana, Facundo Garcia-Bournissen, Jaime Altcheh, Bethania Blum, Fabiana Alves, Isabela Ribeiro
Chagas Disease (CD) is recognized as one of the major global neglected tropical diseases. Benznidazole (BNZ) is the drug of choice for the treatment of adults, young infants, and newborns with CD. However, the pharmacokinetics (PK) of BNZ has been poorly evaluated in all age groups, with consequent gaps in knowledge about PK-PD relationships in CD. The purpose this study was to develop and validate a bioanalytical method to quantify BNZ levels in small volume whole blood samples collected as dried blood spots (DBS)...
October 1, 2018: Antimicrobial Agents and Chemotherapy
Paulo H Harada, Marcio H Miname, Isabela M Benseñor, Raul D Santos, Paulo A Lotufo
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a genetic disorder associated with high cardiovascular burden of disease. FH prevalence may vary widely across populations and data in race/ethnically diverse and admixed populations is scarce. ELSA-Brasil epidemiology may be widely generalizable in this regard, and we calculated the ELSA-Brasil FH prevalence and its variation according to age, sex and race/ethnicity. METHODS: In 14,460 individuals aged from 35 to 75 years from the ELSA-Brasil cohort baseline, we classified FH according to the Dutch Lipid Clinic Network criteria score ≥6 (probable and definite FH)...
October 2018: Atherosclerosis
Todd Bradley, Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W Cain, Ricardo Henao, Vaishnavi Venkat, Bhavna Hora, Yue Chen, Nathan A Vandergrift, R Glenn Overman, R Whitney Edwards, Chris W Woods, Georgia D Tomaras, Guido Ferrari, Geoffrey S Ginsburg, Mark Connors, Myron S Cohen, M Anthony Moody, Persephone Borrow, Barton F Haynes
HIV-1 broadly neutralizing antibodies (bnAbs) are difficult to induce with vaccines but are generated in ∼50% of HIV-1-infected individuals. Understanding the molecular mechanisms of host control of bnAb induction is critical to vaccine design. Here, we performed a transcriptome analysis of blood mononuclear cells from 47 HIV-1-infected individuals who made bnAbs and 46 HIV-1-infected individuals who did not and identified in bnAb individuals upregulation of RAB11FIP5, encoding a Rab effector protein associated with recycling endosomes...
October 4, 2018: Cell
Thalita Alves Zanetti, Bruna Isabela Biazi, Adrivanio Baranoski, Gláucia Fernanda Rocha D'Epiro, Amanda Cristina Corveloni, Simone Cristine Semprebon, Giuliana Castello Coatti, Mário Sérgio Mantovani
Oxidative stress (OS) is involved in the onset of various pathological processes, and sodium selenite (Na2 SeO3 ) is known to have antioxidant activity. This study evaluated the cellular response of human HepG2/C3A cells supplemented with Na2 SeO3 when exposed to hydrogen peroxide (H2 O2 )-induced OS. We analyzed cytotoxicity, cell proliferation, and genotoxicity in comparison with molecular data of mRNA and protein expression. The MTT and comet assays revealed that Na2 SeO3 conferred cytoprotective and anti-genotoxic effects...
December 2018: Journal of Trace Elements in Medicine and Biology
Isabela Monteiro A, Tarek Kollmetz, Jenny Malmström
While tremendous leaps in knowledge into cellular signaling and control have been achieved over the last few decades, there is still more to learn in how different signaling pathways act synergistically. A better understanding and control of cells in vitro and in vivo is important to enable more successful and safe applications of tissue engineering and stem cell therapy. This review is focused on two central ways cells sense their surroundings, namely, integrin-mediated mechanotransduction and growth factor signaling...
September 24, 2018: Biointerphases
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