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Juliana de A S Gomes, Fernanda F de Araújo, Daniele M Vitelli-Avelar, Renato Sathler-Avelar, Paula S Lage, Ana P B Wendling, Isabela N P C do Vale, João C P Dias, Silvana M Elói-Santos, Andréa Teixeira-Carvalho, Olindo A Martins-Filho
The systems biology approach has become an innovative tool when it comes to shedding light on the complex immune response underlying the development/maintenance of distinct clinical forms of Chagas disease. The goal of this study was to describe an integrative overview of Fc-γR expression, cytokine microenvironment and anti- Trypanosoma cruzi IgG interface in indeterminate-(IND) and cardiac-(CARD) patients. Data demonstrated that IND displayed an overall higher Fcγ-R expression (CD16; CD32; CD64) on neutrophils-(NEU), along with (CD16; CD64) on monocytes-(MON) as compared to CARD...
2018: Frontiers in Microbiology
Margaret B Nolan, Henk J Bertschinger, Robyn Roth, Michael Crampton, Isabela S Martins, Geoffrey T Fosgate, Tom A Stout, Martin L Schulman
An important determinant in the selection of any contraceptive agent is the impact on ovarian function, both in the short and longer term. In this study, ovarian activity was monitored in mares immunised with one of the following vaccine formulations; native porcine zona pellucida (pZP), recombinant zona pellucida proteins ZP3 and ZP4 (reZP), pZP and reZP combined or a commercially available anti-GnRH vaccine. The ZP antigens were prepared in an adjuvant formulation consisting of 6% polymeric adjuvant (Montanide™ PetGel A, Seppic, France) and 500 μg polyinosinic-polycytidylic acid - TLR3-agonist (Poly(I:C) HMW VacciGrade™, Invivogen, USA)...
August 2, 2018: Theriogenology
Jessica S B Figueira, Luiza B Pacheco, Isabela Lobo, Eliane Volchan, Mirtes G Pereira, Leticia de Oliveira, Isabel A David
Some studies have demonstrated a beneficial role of Positive Affect on working memory (WM) by either applying protocols of mood induction or assessing naturally occurring state Positive Affect. However, there are no studies directly linking Positive Affect as a stable personality-like trait with WM. We aimed to address this potential relationship using the Positive and Negative Affect Schedule scale and contra-lateral delay activity (CDA) as measures of trait Positive Affect and WM Capacity, respectively. We also sought to investigate the impact of a neutral or unpleasant emotional state on this relationship...
2018: Frontiers in Psychology
Isabela Bruna Pires Borges, Marilda Guimarães Silva, Samuel Katsuyuki Shinjo
BACKGROUND: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. OBJECTIVES: To analyze this autoantibody in the Brazilian population. METHODS: This was a single-center cross-sectional study in which 131 consecutive adult patients (109 dermatomyositis and 22 clinically amyopathic dermatomyositis) with active disease were evaluated from 2000 to 2016...
July 2018: Anais Brasileiros de Dermatologia
Renata S Rabelo, Isabela F Oliveira, Vanessa M da Silva, Ana S Prata, Miriam D Hubinger
A nanostructured lipid carrier (NLC) has been developed as a loading system for Vitamin D (VD). The NLCs were obtained by melt-emulsification method and coated with chitosan (CHI) by electrostatic deposition. The lipids used in the formulations were selected in order to provide higher encapsulation efficiency. Thermophysical properties of particles were evaluated by differential scanning calorimetry; particle stability was characterized by size distribution, polydispersity index, zeta-potential and light backscattering...
July 28, 2018: International Journal of Biological Macromolecules
Jordana Herzog Siqueira, José Geraldo Mill, Gustavo Velasquez-Melendez, Alexandra Dias Moreira, Sandhi Maria Barreto, Isabela Martins Benseñor, Maria Del Carmen Bisi Molina
The secular trend of hyperuricemia coincides with the substantial increase in the consumption of sugar-sweetened beverages. Our aim was to evaluate the association between the consumption of soft drinks, dietary fructose and unsweetened, non-processed fruit juices with hyperuricemia in a cross-sectional analysis of baseline data (2008⁻2010; n = 7173) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The explanatory variables were the consumption of soft drinks, fruit juice, and fructose using a validated semi-quantitative food frequency questionnaire...
July 27, 2018: Nutrients
Paulo Henrique Couto Souza, Soraya de Azambuja Berti-Couto, Cassiana Nathalie Machado Majewski, Isteicy Cortez Silva, Liziane Cattelan Donaduzzi, Isabela Maria Vasconcelos Silva, Maria do Carmo Lisboa, Urie K Lee, Ida K Friedlander, Arthur H Friedlander
OBJECTIVES: Brazilians who are free of traditional atherogenic risk factors frequently suffer myocardial infarctions (MI). Calcified carotid artery plaque (CCAP) on panoramic images (PIs) has been shown to be a vali-dated "risk indicator" of future MIs. The diagonal ear lobe crease (DELC) is likewise a validated "risk indicator" of future MI. We sought to determine the prevalence of DELC+ among patients having CCAP+ on their PIs. METHODS: In a masked cross-sectional study, three dentists evaluated PIs of patients (N = 481) over age 55 for presence of CCAP+...
July 30, 2018: Dento Maxillo Facial Radiology
Domenico Ricucci, Weber S P Lopes, Simona Loghin, Isabela N Rôças, José F Siqueira
This article describes a case of large persistent posttreatment apical periodontitis associated with 2 maxillary incisors, which was successfully managed by periradicular surgery. Histobacteriologic analysis revealed that the lesion was a granuloma that contained in its body a very large actinomycoticlike colony surrounded by accumulations of polymorphonuclear leukocytes and showing no direct communication with the root canal systems from both teeth. One incisor had no evidence of persistent intraradicular infection, whereas the other exhibited some residual dentinal tubule infection in the apical canal, which may have not significantly contributed to persistent inflammation given the organization and agglomeration of inflammatory cells around the large extraradicular bacterial colony...
August 2018: Journal of Endodontics
Claudia Januário Dos Santos, Fabiane Lucy Ferreira Castro, Rodrigo Barbosa de Aguiar, Isabela Godoy Menezes, Ana Carolina Santos, Christina Paulus, Michael Nevels, Maria Cristina Carlan da Silva
The relationship between human cytomegalovirus (HCMV) and tumours has been extensively investigated, mainly in glioblastoma multiforme (GBM), a malignant tumour of the central nervous system with low overall survival rates. Several reports have demonstrated the presence of HCMV in GBM, although typically restricted to a low number of cells, and studies have indicated that viral proteins have the ability to dysregulate cellular processes and increase tumour malignancy. Treatment of GBM involves the use of the chemotherapeutic agents temozolomide (TMZ) and carmustine (bis-chloroethylnitrosourea, BCNU), which lead to the attachment of adducts to the DNA backbone, causing errors during replication and consequent cell death...
July 25, 2018: Journal of General Virology
Inaê Costa Rechia, Isabela de Moraes Fattore, Anaelena Bragança de Moraes, Eliara Pinto Vieira Biaggio, Ana Paula Ramos de Souza
PURPOSE: To assess the potential association between psychological risk and limited auditory pathway maturation. METHODS: In this longitudinal cohort study, 54 infants (31 non-risk and 23 at-risk) were assessed from age 1 to 12 months. All had normal hearing and underwent assessment of auditory maturation through cortical auditory evoked potentials testing. Psychological risk was assessed with the Child Development Risk Indicators (CDRIs) and PREAUT signs. A variety of statistical methods were used for analysis of results...
July 19, 2018: CoDAS
Ivano E Castelli, Stefan G Soriga, Isabela C Man
Understanding hydrogen diffusion is important for applications such as hydrogen storage and spillover materials. On semiconductors, where paired electron acceptors and donors stabilize each other, the hydrogen diffusion depends on the number of adsorbed fragments. Using density functional theory, we investigate the effects of preadsorbed hydrogens on activation energy and reaction path for hydrogen diffusion on MgO(100): the presence of an unpaired hydrogen causes a diffusion, on O-sites, above the surface with a lower activation energy compared to the case of paired hydrogens where the diffusion distorts the surface...
July 21, 2018: Journal of Chemical Physics
Isabela Marques Miziara, Jamile Benite Palma Lopes, Danial Kahani, Roberta Delasta Lazzari, R Moura, Bernard Arthur Conway, Claudia Santos Oliveira, Eduardo Lázaro Martins Naves
The fundamental characteristic of hemiparetic cerebral palsy is the greater motor impairment on the body side that corresponds to the injured cerebral hemisphere. Hemiparesis usually affects the upper limbs, which can provide significant functional disabilities to this population. The objective of this study was to compare alpha and beta band synchronization and desynchronization during the execution of the task in a game, using the limbs paretic and non-paretic. As a result, observed a synchronization of the alpha band for the movement performed by the paretic limb and a desynchronization using the non-paretic limb...
July 18, 2018: Gait & Posture
Eduardo Morato de Oliveira, José Alcides Almeida de Arruda, Polianne Alves Mendes Nascimento, Isabela Moreira Neiva, Ricardo Alves Mesquita, Leandro Napier Souza
PURPOSE: The aims of the present study were to discuss the demographic distribution and clinical characteristics of patients with pycnodysostosis (PYCD) and the onset of osteomyelitis and its treatment using a literature review. The authors also report on an update of treatment of mandibular osteomyelitis in a patient with PYCD using a buccal fat pad (BFP) as a free graft. PATIENTS AND METHODS: The study was carried out in 2 steps. In the first step, an electronic search was undertaken in PubMed in March 2018, with 17 articles being included...
June 26, 2018: Journal of Oral and Maxillofacial Surgery
Giuliano Generoso, Isabela M Bensenor, Itamar S Santos, Raul D Santos, Alessandra C Goulart, Steven R Jones, Krishnaji R Kulkarni, Michael J Blaha, Peter P Toth, Paulo A Lotufo, Marcio Sommer Bittencourt
INTRODUCTION: High-density lipoprotein cholesterol comprises a group of heterogeneous subfractions that might have differential effects on atherosclerosis. Moreover, prior investigations suggest that the presence of diabetes (T2D) modifies the impact of some subfractions on atherosclerosis. In this study, we aimed to evaluate the association between high-density lipoprotein cholesterol subfractions and carotid intima-media thickness in the baseline assessment of the Brazilian Longitudinal Study of Adult Health participants from the São Paulo investigation centre...
July 1, 2018: Diabetes & Vascular Disease Research
Isabela Soares Santos, Fabiola Sulpino Vieira
The article analyzes the implications of the austerity policy in Brazil on the guarantee of universal social rights, focusing on the financing of the Unified Health System (SUS) and the right to health. The effects of the Brazilian austerity policy are analyzed in an international perspective, based on evidence produced in different contexts, identified from a literature review, in order to base the arguments developed in the article. Information on the fiscal austerity measures being implemented in Brazil is presented and its likely impacts on social protection in the country are analyzed in a context of significant economic recession...
July 2018: Ciência & Saúde Coletiva
Neusa Barros Dantas-Neta, Mariana Soares Figueiredo, Cacilda Castelo Branco Lima, Cristiane Baccin Bendo, Éllen Maria Matos de Andrade, Marina de Deus Moura Lima, Isabela Almeida Pordeus, Saul Martins Paiva
BACKGROUND: The aetiology of molar-incisor hypomineralisation (MIH) is multifactorial and may involve genetic and environmental factors. AIM: To verify the factors associated with MIH in schoolchildren from 8 to 10 years of age. DESIGN: This is a case-control study with a sample consisting of children aged 8 to 10 years, paired by gender and school type, in a ratio of 1:3. The case group included 186 children with MIH and the control included 558 children without MIH...
July 17, 2018: International Journal of Paediatric Dentistry
Isabela B Dos Santos, Danielle A M da Silva, Fabiana A C R Paz, Daniel M Garcia, Adriana K Carmona, Daniela Teixeira, Ieda M Longo-Maugéri, Simone Katz, Clara L Barbiéri
The present study focused on the activity of the palladacycle complex DPPE 1.1 on Leishmania (Leishmania) amazonensis . Promastigotes of L. (L.) amazonensis were destroyed in vitro by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes were killed at drug concentrations fivefold less toxic than those harmful to macrophages. L. (L.) amazonensis -infected BALB/c mice were treated by intralesional injection of DPPE 1.1. Animals treated with 3.5 and 7.0 mg/kg of DPPE 1.1 showed a significant decrease of foot lesion sizes and a parasite load reduction of 93 and 99%, respectively, when compared to untreated controls...
2018: Frontiers in Microbiology
Landry Blanc, Jansy Passiflora Sarathy, Nadine Alvarez Cabrera, Paul O'Brien, Isabela Dias-Freedman, Marizel Mina, James Sacchettini, Radojka M Savic, Martin Gengenbacher, Brendan K Podell, Brendan Prideaux, Thomas Ioerger, Thomas Dick, Véronique Dartois
In the 1970s, inclusion of pyrazinamide (PZA) in the drug regimen of tuberculosis (TB) patients for the first 2 mo achieved a drastic reduction of therapy duration. Until now, however, the mechanisms underlying PZA's unique contribution to efficacy have remained controversial, and animal efficacy data vary across species. To understand how PZA kills bacterial populations present in critical lung lesion compartments, we first characterized a rabbit model of active TB, showing striking similarities in lesion types and fates to nonhuman primate models deemed the most appropriate surrogates of human TB...
August 6, 2018: Journal of Experimental Medicine
Ingrid Felicidade, Daniele Sartori, Susan L M Coort, Simone Cristine Semprebon, Andressa Megumi Niwa, Gláucia Fernanda Rocha D'Epiro, Bruna Isabela Biazi, Lilian Areal Marques, Chris T Evelo, Mário Sérgio Mantovani, Lúcia Regina Ribeiro
BACKGROUND/AIMS: Compared with non-obese individuals, obese individuals commonly store more vitamin D in adipose tissue. VDR expression in adipose tissue can influence adipogenesis and is therefore a target pathway deserving further study. This study aims to assess the role of 1,25(OH)2D3 in human preadipocyte proliferation and differentiation. METHODS: RTCA, MTT, and trypan blue assays were used to assess the effects of 1,25(OH)2D3 on the viability, proliferation, and adipogenic differentiation of SGBS cells...
July 17, 2018: Cellular Physiology and Biochemistry
Anouk Poppelaars, Hanneke Scholten, Isabela Granic, Harm Veling, Mina C Johnson-Glenberg, Maartje Luijten
Overweight and obesity are major causes of worldwide morbidity and mortality. A two-armed randomized controlled trial (n = 104) examined the effectiveness of Hit n Run, a video game based on the principles of Go/No-Go inhibition training, in young adults who reported disinhibited eating. Adults (aged 18 to 30) were randomly assigned to play Hit n Run or received an informative brochure (Healthy Eating Step by Step; HESbS). Prior to and directly following the intervention week general and food-specific inhibitory control, caloric intake, and perceived attractiveness of food pictures were assessed...
July 3, 2018: Appetite
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