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M Sommerfeld, Y Cui, S Schmalfuß
For about 15 years the performance of dry powder inhalers (DPIs) has been numerically analysed through CFD (computational fluid dynamics) approaches with the objective of understanding the evolving flow structures and the resulting transport of drug particles. Naturally the main interest is the numerical prediction of the emitted fine particle fraction (FPF) which is able to penetrate the lung airways. Due to the mostly used drug formulations (i.e. carrier-based or agglomerated drug powder) and the complex elementary processes occurring during the transport of such particles through inhalers this is not an easy task...
December 13, 2018: European Journal of Pharmaceutical Sciences
W Scott Comulada, Wenze Tang, Dallas Swendeman, Amy Cooper, Jeremy Wacksman
BACKGROUND: Advancing technology has increased functionality and permitted more complex study designs for behavioral interventions. Investigators need to keep pace with these technological advances for electronic data capture (EDC) systems to be appropriately executed and utilized at full capacity in research settings. Mobile technology allows EDC systems to collect near real-time data from study participants, deliver intervention directly to participants' mobile devices, monitor staff activity, and facilitate near real-time decision making during study implementation...
December 14, 2018: JMIR Research Protocols
Wenyu Mao, Rongxuan Shen, Ke Wang, Guoliang Gong, Yi Xiao, Huaxiang Lu
Device-free localization (DFL) is a new technique which can estimate the target location through analyzing the shadowing effect on surrounding radio frequency (RF) links. In a relatively complex environment, the influences of random disturbance and the multipath effect are more serious. There are kinds of noises and disturbances in the received signal strength (RSS) data of RF links and the data itself can even be distorted, which will seriously affect the DFL accuracy. Most of the common filtering methods adopted in DFL field are not targeted and the filtering effects are unstable...
December 13, 2018: Sensors
Hongcheng Huang, Wei Xiang, Yang Tao, Biao Liu, Min Hu
Relay-assisted Device-to-Device (D2D) communication, one of the important transmission modes in mobile health systems, can provide high transmission quality for servicing users at the edge of system coverage. However, the quality of the D2D relay communication is largely limited by the relay nodes. When a poor node is selected to assist the source node in the data transmission, it is likely to result in the loss of medical data and inaccurate transmission. Therefore, this paper focuses on how to select relay modes and relay nodes to improve the reliability of medical data transmission...
December 13, 2018: Sensors
Zhong Zhang, Xin Ma, Mengfan Jia, Bowei Li, Jianhui Rong, Xingbin Yang
Rapid detection of pesticides in fruits is an ongoing challenge. The objective of the present study was to develop novel fluorescent microfluidic paper chips for specific recognition and sensitive detection of the pesticide 2,4-D through the electron-transfer-induced fluorescence quenching mechanism. CdTe quantum dots (QDs) were deposited onto cellulose paper (base material) to yield imprinted paper chips (paper@QDs@MIPs). This method allows the transferability of the molecularly imprinted fluorescence sensor from the liquid phase to the solid phase (paper base) for rapid and portable analysis...
December 14, 2018: Analyst
Lorenzo Garavaglia, Emanuela Pagliano, Giovanni Baranello, Simone Pittaccio
BACKGROUND: Movement Disorders (MD) are a class of disease that impair the daily activities of patients, conditioning their sensorimotor, cognitive and behavioural capabilities. Nowadays, the general management of patients with MD is based on rehabilitation, pharmacological treatments, surgery, and traditional splints. Although some attempts have been made to devise specific orthoses for the rehabilitation of patients affected by MD, especially the younger ones, those devices have received limited attention...
December 14, 2018: Journal of Neuroengineering and Rehabilitation
Guo Zou, Li Zhao, Longwei Zeng, Kaijun Luo, Hailiang Ni, Haifeng Wang, Quan Li, Wenhao Yu, Xuelian Li
In this paper, we have designed and synthesized a series of neutral liquid-crystalline iridium(III) complexes based on polycatenar 2,5-diphenylpyridine and pyridyltetrazolate derivatives. Iridium(III) complexes all display highly emissive behavior with photoluminescence quantum yields in the range of 0.45-0.66 and a maximum emission wavelength at ∼563 nm. Hexagonal columnar mesophases of iridium(III) complexes can be obtained by changing the number and length of peripheral alkoxyl chains attached to a 2,5-diphenylpyridine ligand (main ligand) and a pyridyltetrazolate ligand (auxiliary ligand)...
December 14, 2018: Inorganic Chemistry
Eitan Ornoy, Shai Cohen
The study of violin recordings as evidence of interpretation and performance approach has been quite extensive throughout recent decades. Findings such as the limited use of vibrato in early recordings, the relative stabilization of tempo and rhythm characteristic of mid-20th century violin playing, or the effect of 'historically informed performance' (HIP) on 'mainstream' (MS) violinists performing early music repertoire, are fundamental in the identification of prevailing norms of practice and changes of style that have occurred over time...
2018: Frontiers in Psychology
Desirée Colombo, Azucena Garcia Palacios, Javier Fernandez Alvarez, Andrea Patané, Michelle Semonella, Pietro Cipresso, Marta Kwiatkowska, Giuseppe Riva, Cristina Botella
BACKGROUND: Ecological momentary assessments (EMAs) and ecological momentary interventions (EMIs) represent a novel approach for the assessment and delivery of psychological support to depressed patients in daily life. Beyond the classical paper-and-pencil daily diaries, the more recent progresses in Information and Communication Technologies (ICT) enabled researchers to bring all the needed processes together in only one device, i.e., response signaling, repeated symptom collection, information storage, secure data transfer, and psychological support delivery...
December 13, 2018: Systematic Reviews
Congfeng Jiang, Tiantian Fan, Yeliang Qiu, Hongyuan Wu, Jilin Zhang, Neal N Xiong, Jian Wan
In virtualized sensor networks, virtual machines (VMs) share the same hardware for sensing service consolidation and saving power. For those VMs that reside in the same hardware, frequent interdomain data transfers are invoked for data analytics, and sensor collaboration and actuation. Traditional ways of interdomain communications are based on virtual network interfaces of bilateral VMs for data sending and receiving. Since these network communications use TCP/IP (Transmission Control Protocol/Internet Protocol) stacks, they result in lengthy communication paths and frequent kernel interactions, which deteriorate the I/O (Input/Output) performance of involved VMs...
December 12, 2018: Sensors
Zhaonian Yang, Yuan Yang, Ningmei Yu, Juin J Liou
Currently, a tunnel field-effect transistor (TFET) is being considered as a suitable electrostatic discharge (ESD) protection device in advanced technology. In addition, silicon-germanium (SiGe) engineering is shown to improve the performance of TFET-based ESD protection devices. In this paper, a new TFET with SiGe source/drain (S/D) regions is proposed, and its ESD characteristics are evaluated using technology computer aided design (TCAD) simulations. Under a transmission line pulsing (TLP) stressing condition, the triggering voltage of the SiGe S/D TFET is reduced by 35% and the failure current is increased by 17% in comparison with the conventional Si S/D TFET...
December 12, 2018: Micromachines
Nélia Alberto, Maria Fátima Domingues, Carlos Marques, Paulo André, Paulo Antunes
Magnetic field sensing is an important issue for many application areas, such as in the military, industry and navigation. The current sensors used to monitor this parameter can be susceptible to electromagnetic interferences, however due to their advantages over the traditional sensors, the optical fiber devices could be an excellent alternative. Furthermore, magnetic fluid (MF) is a new type of functional material which possesses outstanding properties, including Faraday effect, birefringence, tunable refractive index and field dependent transmission...
December 7, 2018: Sensors
Yidan Shang, Jingliang Dong, Lin Tian, Kiao Inthavong, Jiyuan Tu
BACKGROUND: Understanding respiratory physiology can aid clinicians in diagnosing the cause of respiratory symptoms or shed light on drug delivery inhaler device optimisation. However, the sheer complexity of the human lung prohibits a full-scale study. METHODS: In this study, a realistic respiratory airway model including large-to-small conducting airways was built. This airway model consists of subject-specific upper and lower airways, extending from nasal and oral openings to terminal bronchioles (up to the 15th generation)...
December 7, 2018: Clinical Biomechanics
Guillaume Longatte, Adnan Sayegh, Jérôme Delacotte, Fabrice Rappaport, Francis-André Wollman, Manon Guille-Collignon, Frédéric Lemaître
Plants, algae, and some bacteria convert solar energy into chemical energy by using photosynthesis. In light of the current energy environment, many research strategies try to benefit from photosynthesis in order to generate usable photobioelectricity. Among all the strategies developed for transferring electrons from the photosynthetic chain to an outer collecting electrode, we recently implemented a method on a preparative scale (high surface electrode) based on a Chlamydomonas reinhardtii green algae suspension in the presence of exogenous quinones as redox mediators...
November 21, 2018: Chemical Science
Vivek Priy Dave, Tien Anh Ngo, Anna-Karin Pernestig, Diana Tilevik, Krishna Kant, Trieu Nguyen, Anders Wolff, Dang Duong Bang
The volume of point of care (POC) testing continues to grow steadily due to the increased availability of easy-to-use devices, thus making it possible to deliver less costly care closer to the patient site in a shorter time relative to the central laboratory services. A novel class of molecules called microRNAs have recently gained attention in healthcare management for their potential as biomarkers for human diseases. The increasing interest of miRNAs in clinical practice has led to an unmet need for assays that can rapidly and accurately measure miRNAs at the POC...
December 12, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Anna Clebone, Kim M Strupp, Gina Whitney, Michael R Anderson, Jeffrey Hottle, James Fehr, Myron Yaster, Laura E Schleelein, Barbara K Burian, Jorge A Galvez, Justin L Lockman, David Polaner, Natalie R Barnett, Michael J Keane, Shashikanth Manikappa, Stephen Gleich, Robert S Greenberg, Ariel Vincent, Sarah L Oswald, Red Starks, Scott Licata
When life-threatening, critical events occur in the operating room, the fast-paced, high-distraction atmosphere often leaves little time to think or deliberate about management options. Success depends on applying a team approach to quickly implement well-rehearsed, systematic, evidence-based assessment and treatment protocols. Mobile devices offer resources for readily accessible, easily updatable information that can be invaluable during perioperative critical events. We developed a mobile device version of the Society for Pediatric Anesthesia 26 Pediatric Crisis paper checklists-the Pedi Crisis 2...
December 11, 2018: Anesthesia and Analgesia
Gitashree Darabdhara, Purna K Boruah, Manash R Das
This work describes the preparation of bimetallic Cu-Pd nanoparticles (NPs) on supports like reduced graphene oxide (rGO), graphitic carbon nitride (g-C3 N4 ) and MoS2 sheets with a size of <10 nm. rGO is found to be the best support for synthesizing Cu-Pd NPs with controlled shape, size and oxidation state. The Cu-Pd/rGO nanocomposite also demonstrated the best peroxidase and oxidase mimicking activity compared to Cu-Pd/g-C3 N4 and Cu-Pd/MoS2 nanocomposites. The peroxidase mimicking activity of Cu-Pd/rGO was investigated in more detail, and a glucose oxidase (GOx) based glucose sensor was constructed that is based on the enzymatic formation of H2 O2 and the Cu-Pd NPs-assisted oxidation of tetramethylbenzidine by H2 O2 to give a blue-green coloration with absorption maxima at 652 nm...
December 11, 2018: Mikrochimica Acta
William H Nailon, Daniel Welsh, Kim McDonald, Donna Burns, Julie Forsyth, Gillian Cooke, Francisco Cutanda, Linda J Carruthers, Duncan B McLaren, Josep Puxeu Vaqué, Terence Kehoe, Sankar Andiappa
BACKGROUND: Independent verification of the dose delivered by complex radiotherapy can be performed by electronic portal imaging device (EPID) dosimetry. This paper presents 5-yr EPID in vivo dosimetry (IVD) data obtained using the Dosimetry Check (DC) software on a large cohort including breast, lung, prostate, and head and neck (H&N) cancer patients. MATERIAL AND METHODS: The difference between in vivo dose measurements obtained by DC and point doses calculated by the Eclipse treatment planning system was obtained on 3795 radiotherapy patients treated with volumetric modulated arc therapy (VMAT) (n = 842) and three-dimensional conformal radiotherapy (3DCRT) (n = 2953) at 6, 10, and 15 MV...
December 7, 2018: Journal of Applied Clinical Medical Physics
Eloise Pariset, Charlotte Parent, Yves Fouillet, Boizot François, Nicolas Verplanck, Frédéric Revol-Cavalier, Aurélie Thuaire, Vincent Agache
Deterministic lateral displacement (DLD) has been extensively implemented in the last decade for size-based sample preparation, owing to its high separation performances for a wide range of particle dimensions. However, separating particles from 1 μm to 10 μm in one single DLD device is challenging because of the required diversity of pillar dimensions and inherent fabrication issues. This paper presents an alternative approach to achieve the extraction of E. coli bacteria from blood samples spiked with prostate cancer cells...
December 10, 2018: Scientific Reports
Grenalynn Ilacas, Frank A Gomez
No abstract text is available yet for this article.
December 7, 2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
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