Venkatesh L Murthy, Jonathan D Mosley, Andrew S Perry, David R Jacobs, Kahraman Tanriverdi, Shilin Zhao, Konrad T Sawicki, Mercedes Carnethon, John T Wilkins, Matthew Nayor, Saumya Das, E Dale Abel, Jane E Freedman, Clary B Clish, Ravi V Shah
While weight gain is associated with a host of chronic illnesses, efforts in obesity have relied on single "snapshots" of body mass index (BMI) to guide genetic and molecular discovery. Here, we study >2,000 young adults with metabolomics and proteomics to identify a metabolic liability to weight gain in early adulthood. Using longitudinal regression and penalized regression, we identify a metabolic signature for weight liability, associated with a 2.6% (2.0%-3.2%, p = 7.5 × 10-19 ) gain in BMI over ≈20 years per SD higher score, after comprehensive adjustment...
April 25, 2024: Cell reports medicine