Till S Zimmer, Bastian David, Diede W M Broekaart, Martin Schidlowski, Gabriele Ruffolo, Anatoly Korotkov, Nicole N van der Wel, Peter C van Rijen, Angelika Mühlebner, Wim van Hecke, Johannes C Baayen, Sander Idema, Liesbeth François, Jonathan van Eyll, Stefanie Dedeurwaerdere, Helmut W Kessels, Rainer Surges, Theodor Rüber, Jan A Gorter, James D Mills, Erwin A van Vliet, Eleonora Aronica
Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species (ROS) could represent an important, yet underappreciated, component of the epileptogenic process. However, to date, alterations in iron metabolism in the epileptogenic brain have not been addressed in detail. Iron-related neuropathology and antioxidant metabolic processes were investigated in resected brain tissue from patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS), post-mortem brain tissue from patients who died after status epilepticus (SE) as well as brain tissue from the electrically induced SE rat model of TLE...
July 22, 2021: Acta Neuropathologica