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https://www.readbyqxmd.com/read/30106361/distinct-pattern-of-neostriatal-calcifications-in-dyskeratosis-congenita-a-case-report-and-literature-review
#1
Maryam Abdollahi, MingYang Meah Gao, David G Munoz
Dyskeratosis congenita (DKC) is a rare, inherited disorder classically known by the triad of nail dystrophy, mucosal leukoplakia, and lacy reticulated skin hyperpigmentation. Bone marrow failure is a prominent feature and accounts for most deaths in these patients. Genetic mutations resulting in shortened telomeres have been shown to cause DKC, which is the basis for categorizing it as a "premature aging syndrome". Different modes of inheritance have been identified with X-linked recessive as the most common...
August 14, 2018: Clinical Neuropathology
https://www.readbyqxmd.com/read/30106317/comparison-of-medical-and-or-surgical-management-of-23-cats-with-intracranial-empyema-or-abscessation
#2
Sophie Martin, Randi Drees, Balazs Szladovits, Elsa Beltran
Objectives Feline intracranial abscessation or empyema is infrequently reported in the veterinary literature. To date, the largest study is based on a population of 19 cats with otogenic infection. The aim of this study was to review a larger population of cats with intracranial empyema from multiple aetiologies and document their signalment, imaging findings, treatment protocols (including medical and/or surgical management) and to compare outcomes. Methods Cases presenting to a single referral centre over a 10 year period with compatible history, neurological signs and imaging findings consistent with intracranial abscessation and empyema were reviewed retrospectively...
August 14, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/30106141/nogo%C3%A2-b-receptor-in-relevant-carcinoma-current-achievements-challenges-and-aims-review
#3
Yu-Kun Li, Yuan-Jie Xie, Dai-Chao Wu, Shuang-Lian Long, Shengsong Tang, Zhong-Cheng Mo
The novel neurite outgrowth inhibitor B (Nogo‑B) receptor (NgBR) is specific for Nogo‑B, which is highly expressed in various human organs and cells, including the lung, liver, kidney, smooth muscle cells, blood vessel endothelial cells and inflammatory cells. Previous studies have indicated that NgBR directly interacts with Nogo‑B and is able to independently influence lipid and cholesterol homeostasis, angiogenesis, N‑glycosylation, the epithelial-mesenchymal transition, the chemotaxis of endothelial cells and cellular proliferation and apoptosis...
August 9, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30105160/neuroimaging-abnormalities-in-patients-with-cowden-syndrome-retrospective-single-center-study
#4
Radhika Dhamija, Steven M Weindling, Alyx B Porter, Leland S Hu, Christopher P Wood, Joseph M Hoxworth
Background: We retrospectively reviewed the neuroimaging findings of patients with Cowden syndrome and determined their frequency in a single cohort. Methods: Electronic medical records were queried from January 1999 to January 2017 to identify patients who fit the clinical criteria for diagnosis of Cowden syndrome with or without a documented PTEN mutation. Patients with brain MRI examinations were then identified. Results: We retrospectively identified 44 patients with Cowden syndrome, 22 of whom had neuroimaging for review...
June 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/30105144/the-role-of-inflammation-and-potential-use-of-sex-steroids-in-intracranial-aneurysms-and-subarachnoid-hemorrhage
#5
REVIEW
Jack W Barrow, Nefize Turan, Pasang Wangmo, Anil K Roy, Gustavo Pradilla
Background: Aneurysmal subarachnoid hemorrhage (aSAH) continues to be a devastating neurological condition with a high risk of associated morbidity and mortality. Inflammation has been shown to increase the risk of complications associated with aSAH such as vasospasm and brain injury in animal models and humans. The goal of this review is to discuss the inflammatory mechanisms of aneurysm formation, rupture and vasospasm and explore the role of sex hormones in the inflammatory response to aSAH...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30105135/one-burr-hole-craniotomy-anterior-interhemispheric-approach-in-helsinki-neurosurgery
#6
Joham Choque-Velasquez, Juha Hernesniemi
Background: In this video-abstract, we present a one burr-hole craniotomy for the anterior interhemispheric approach developed in Helsinki Neurosurgery to access the medial surface of cerebral hemispheres, the falx cerebri, the distal segment of the anterior cerebral artery, the corpus callosum, the third ventricle, and the lateral ventricles. Therefore, preoperative imaging is essential to achieve an optimal operative corridor for safest and more effcient approach. Case Description: The patient with a no ruptured right pericallosal aneurysm is placed in semi-sitting position...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30105125/microvascular-anastomosis-under-3d-exoscope-or-endoscope-magnification-a-proof-of-concept-study
#7
Evgenii Belykh, Laeth George, Xiaochun Zhao, Alessandro Carotenuto, Leandro Borba Moreira, Kaan Yağmurlu, Baran Bozkurt, Vadim A Byvaltsev, Peter Nakaji, Mark C Preul
Background: Extracranial-intracranial bypass is a challenging procedure that requires special microsurgical skills and an operative microscope. The exoscope is a tool for neurosurgical visualization that provides view on a heads-up display similar to an endoscope, but positioned external to the operating field, like a microscope. The authors carried out a proof-of-concept study evaluating the feasibility and effectiveness of performing microvascular bypass using various new exoscopic tools...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30104292/durable-response-to-nivolumab-in-a-pediatric-patient-with-refractory-glioblastoma-and-constitutional-biallelic-mismatch-repair-deficiency
#8
Musa AlHarbi, Nahla Ali Mobark, Latifa AlMubarak, Rasha Aljelaify, Mariam AlSaeed, Amal Almutairi, Fatmah Alqubaishi, M Emarat Hussain, Ali Abdullah O Balbaid, Amal Said Marie, Lamia AlSubaie, Saeed AlShieban, Nada alTassan, Shakti H Ramkissoon, Malak Abedalthagafi
Primary brain tumors are a leading cause of cancer-related morbidity and mortality in children. Glioblastoma (GBM) is a high-grade astrocytoma that occurs in both children and adults and is associated with a poor prognosis. Despite extensive study in recent years, the clinical management of these tumors has remained largely unchanged, consisting of surgical resection, conventional chemotherapy, and radiotherapy. Although the etiology and genomic drivers in GBM are diverse, constitutional mismatch repair-deficiency (CMMRD) syndrome is a rare, recessively inherited disease with a predisposition to gliomagenesis...
August 13, 2018: Oncologist
https://www.readbyqxmd.com/read/30103056/association-of-neutrophil-to-lymphocyte-ratio-on-90-day-functional-outcome-in-intracerebral-hemorrhage-patients-undergoing-surgical-treatment
#9
Zhang F, Tao C, Hu X, Qian J, Li X, You C, Jiang Y, Yang M
BACKGROUND: Inflammatory response plays a vital role in the pathological mechanism of intracerebral hemorrhage. It has been recently reported that neutrophil to lymphocyte ratio (NLR) could represent a novel composite inflammatory marker for predicting the prognosis of intracranial hemorrhage (ICH). However, in considering that surgical evacuation effects on the initiation of inflammatory responses. Thus, the relationship between NLR and functional outcome of ICH patients after surgical treatment is still controversial...
August 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30102896/increased-serum-interleukin-33-concentrations-predict-worse-prognosis-of-aneurysmal-subarachnoid-hemorrhage
#10
Jiangbiao Gong, Yu Zhu, Jianbo Yu, Jing Jin, Mantao Chen, Wenchao Liu, Renya Zhan
BACKGROUND: Interleukin-33 (IL-33) is an inflammatory biomarker. We elucidated the relationship between serum IL-33 concentrations, severity and prognosis in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: We prospectively recruited 175 controls and 175 aSAH patients. Serum IL-33 concentrations were gauged using an enzyme-linked immunosorbent assay. Clinical and radiological severity was assessed by World Federation of Neurological Surgeons (WFNS) scale and modified Fisher grading scale respectively...
August 10, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/30101641/visibility-graph-analysis-of-intraspinal-pressure-signal-predicts-functional-outcome-in-spinal-cord-injured-patients
#11
Suliang Chen, Mathew J Gallagher, Florence Hogg, Marios C Papadopoulos, Samira Saadoun
To guide management of patients with acute spinal cord injuries, we developed intraspinal pressure monitoring from the injury site. Here, we examine the complex fluctuations in the intraspinal pressure signal using network theory. We analyzed 7,097 hours of intraspinal pressure data from 58 patients with severe cord injuries. Intraspinal pressure signals were split into hourly windows. Each window was mapped into a visibility graph as follows: Vertical bars were drawn at 0.1 Hz representing signal amplitudes...
August 13, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/30101347/epilepsyecosystem-org-crowd-sourcing-reproducible-seizure-prediction-with-long-term-human-intracranial-eeg
#12
Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothée Proix, Michal Náhlík, Daniel B Grunberg, Chip Reuben, Gregory Worrell, Brian Litt, David T J Liley, David B Grayden, Mark J Cook
Accurate seizure prediction will transform epilepsy management by offering warnings to patients or triggering interventions. However, state-of-the-art algorithm design relies on accessing adequate long-term data. Crowd-sourcing ecosystems leverage quality data to enable cost-effective, rapid development of predictive algorithms. A crowd-sourcing ecosystem for seizure prediction is presented involving an international competition, a follow-up held-out data evaluation, and an online platform, Epilepsyecosystem...
August 8, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/30101327/microsurgical-clip-placement-for-a-giant-anterior-communicating-artery-aneurysm-with-intraluminal-thrombus-2-dimensional-operative-video
#13
Guilherme Salemi Riechelmann, Marcos Devanir Silva da Costa, Ricardo Lourenço Caramanti, Marcelo Augusto Acosta Goiri, Bruno Lourenço Costa, Kléber González-Echeverría, Feres Chaddad-Neto
Giant brain aneurysms account for approximately 5% of all intracranial aneurysms. Although treatment modalities can vary widely, none is ideal for every patient. Endovascular treatment is usually preferred, especially when the large size of the aneurysm limits visualization of the brain parenchyma and parent vessels that arise from the aneurysm, making surgical clip placement across the neck a difficult task. However, despite the higher chances of morbidity, microsurgery is an effective treatment modality due to lower recurrence rates...
August 8, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30101062/sex-specific-hippocampus-volume-changes-in-obstructive-sleep-apnea
#14
Paul M Macey, Janani P Prasad, Jennifer A Ogren, Ammar S Moiyadi, Ravi S Aysola, Rajesh Kumar, Frisca L Yan-Go, Mary A Woo, M Albert Thomas, Ronald M Harper
Introduction: Obstructive sleep apnea (OSA) patients show hippocampal-related autonomic and neurological symptoms, including impaired memory and depression, which differ by sex, and are mediated in distinct hippocampal subfields. Determining sites and extent of hippocampal sub-regional injury in OSA could reveal localized structural damage linked with OSA symptoms. Methods: High-resolution T1-weighted images were collected from 66 newly-diagnosed, untreated OSA (mean age ± SD: 46...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/30100551/surgery-in-patients-with-childhood-onset-epilepsy-analysis-of-complications-and-predictive-risk-factors-for-a-severely-complicated-course
#15
Piergiorgio d'Orio, Michele Rizzi, Valeria Mariani, Veronica Pelliccia, Giorgio Lo Russo, Francesco Cardinale, Michele Nichelatti, Lino Nobili, Massimo Cossu
OBJECT: To compare the occurrence of surgery-related complications in patients with childhood-onset focal epilepsy operated on in the paediatric or in the adult age. To investigate risk factors for surgery-related complications in the whole cohort, with special attention to age at surgery and severe morbidity. METHODS: A cohort of 1282 patients operated on for childhood-onset focal epilepsy was retrospectively analysed. Occurrence of surgery-related complications, including a severely complicated course (SCC: surgical complication requiring reoperation and/or permanent neurological deficit and/or death), was compared between patients operated on in the paediatric age (<16 year-old; 452 cases) and, respectively, in adulthood (≥16 year-old; 830 cases)...
August 12, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/30099920/genetic-polymorphism-of-vkorc1-1639-in-children-with-intracranial-hemorrhage-due-to-vitamin-k-deficiency
#16
Uğur Berber, Mehmet Akif Özdemir, Ekrem Unal, Serpil Taheri, Serkan Yildiz, Keziban Korkmaz Bayramov, Yunus Güler, Hüseyin Per
Intracranial hemorrhage due to vitamin K deficiency is a serious disease that can lead to morbidity, mortality, and mental retardation. Our goal in this study is to determine the frequency of VKORC1-1639 G>A polymorphism in patients who have undergone intracranial hemorrhage due to vitamin K deficiency bleeding (VKDB). To study VKORC1-1639 G>A polymorphism, blood was drawn from patients (n = 51, age 8:0 ± 6:5 years) followed at the Pediatric Neurology and Hematology section, Faculty of Medicine, Erciyes University, between 1990 and 2016, diagnosed with VKDB as idiopathic or from patients diagnosed with intracranial hemorrhage due to secondary vitamin K deficiency and also from volunteers (n = 51, age 11 ± 4...
August 13, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/30099556/far-lateral-craniotomy-for-posterior-inferior-cerebellar-artery-posterior-inferior-cerebellar-artery-bypass-and-trapping-of-posterior-inferior-cerebellar-artery-aneurysm-3-dimensional-operative-video
#17
Sirin Gandhi, Justin Mascitelli, Douglas Hardesty, Michael T Lawton
Posterior inferior cerebellar artery (PICA) aneurysms account for 3% to 4% of all intracranial aneurysms with an unusually high predilection towards a nonsaccular morphology making microsurgical clipping or endovascular reconstruction of the parent artery difficult. The management of these complicated aneurysms may require revascularization procedures for flow preservation with aneurysm trapping. Recently, there is an increasing inclination towards intracranial-intracranial (IC-IC) bypasses over traditional extracranial donors...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30099539/general-principles-for-preoperative-planning-and-microsurgical-treatment-of-pediatric-brain-arteriovenous-malformations-2-dimensional-operative-video
#18
David L Penn, Kyle C Wu, Kayla R Presswood, Coleman P Riordan, R Michael Scott, Edward R Smith
Children with arteriovenous malformations (AVMs) are at cumulative, life-long risk of debilitating and fatal intracranial hemorrhage, especially with syndromes such as hereditary hemorrhagic telangiectasia. Cerebral angiography is the gold standard for diagnosis and allows simultaneous adjunctive embolization limiting radiation and contrast exposure and intraoperative blood loss, important in pediatric patients with low blood volume. Microsurgical resection of low-grade AVMs offers cure with minimal morbidity...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30099507/recanalization-of-acute-common-carotid-artery-occlusion-2-dimensional-operative-video
#19
Thomas J Sorenson, Harry Cloft, Alejandro Rabinstein, Giuseppe Lanzino
While revascularization of the acutely or chronically occluded internal carotid artery has become commonplace with modern endovascular techniques, revascularization of an acutely occluded common carotid artery (CCA) is a controversial procedure with unique challenges. These challenges can be related to the lack of observable markers for identifying vessels during navigation or for identifying the exact location and extent of occlusion within the CCA, in addition to wide-ranging treatment risks. In this video, we illustrate the controversial revascularization of a 68-yr-old woman with an acute CCA occlusion who presented with fluctuating neurological symptoms...
August 7, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/30099270/investigating-the-efficacy-of-a-new-intravenous-iv-nanoemulsified-sevoflurane-arginine-formulation-for-maintenance-of-general-anesthesia-for-embolization-of-cerebral-aneurysm
#20
Yu Liu, Yaoxian Zhang, Zihao Zheng, Xicheng Liu
The aim of this research investigation was to profound analysis the mitigating impact of sevoflurane/arginine post-molding on cerebral ischemia-reperfusion damage in rats. The authors fabricated emulsions fusing sevoflurane, perfluorooctyl bromide as a settling specialist, and mixes of arginine polymer. Cell suitability and gene expression of tubulin and NeuN were assessed. The stability, morphology and functional group were evaluated utilizing dynamic light scattering (DLS), Transmission Electron Microscope (TEM), atomic force microscopy (AFM), and Fourier-transform infrared spectroscopy (FTIR)...
July 18, 2018: Journal of Photochemistry and Photobiology. B, Biology
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