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https://www.readbyqxmd.com/read/30325990/every-trauma-system-is-perfectly-designed-to-get-the-results-it-gets
#1
Steven M Steinberg
No abstract text is available yet for this article.
September 19, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/30325722/measurement-properties-of-the-upright-motor-control-test-in-adults-with-subacute-stroke
#2
Maribeth Anne P Gelisanga, Edward James R Gorgon
BACKGROUND: Previous studies have distilled the Upright Motor Control Test Knee Extension and Knee Flexion subscales (UMCT-KE and UMCT-KF, respectively) from the original 6-item instrument and examined these as stand-alone rapid tests of voluntary movement control in the standing position. Systematic review evidence suggests that the UMCT-KE and UMCT-KF may have value in predicting walking ability after stroke. OBJECTIVE: To examine the interrater and intrarater reliability, and concurrent validity of the UMCT-KE and UMCT-KF, and associations with walking ability in adults with subacute stroke...
October 16, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/30325549/evaluation-of-breast-cancer-morphology-using-diffusion-weighted-and-dynamic-contrast-enhanced-mri-intermethod-and-interobserver-agreement
#3
Niko Radovic, Gordana Ivanac, Eugen Divjak, Iva Biondic, Antonio Bulum, Boris Brkljacic
BACKGROUND: The capability of diffusion-weighted imaging (DWI) for morphological analysis of breast lesions is underexplored. PURPOSE: To evaluate the utility of DWI for assessment of morphological features of breast cancer by comparing DWI and dynamic contrast-enhanced (DCE) MRI findings to determine intermethod and interobserver agreement. STUDY TYPE: Retrospective. POPULATION: Seventy-eight women with pathohistologically proven breast cancer...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30325287/how-to-get-and-keep-your-lab-funded
#4
Jonathan Chernoff
Much has been written about the seemingly capricious manner by which grant proposals are ranked and awarded by the National Institutes of Health and similar agencies, yet some scientists are able to maintain stable funding over long periods of time. While raw luck may certainly play a role in this process, particularly when paylines are tight, it is also possible that skill-in the art of grant writing at least-could represent a decisive factor. Here, I submit that, even as we attempt to reform and one day perfect the grant review process, there are actions that applicants can take today to get better results from the system we have...
October 15, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/30324595/generation-of-ectopic-morphogen-gradients-in-the-zebrafish-blastula
#5
Maraysa de Olivera-Melo, Peng-Fei Xu, Nathalie Houssin, Bernard Thisse, Christine Thisse
In the zebrafish embryo, cells of the early blastula animal pole are all equivalent and are fully pluripotent until the midblastula transition that occurs at the tenth cell cycle (512 to 1K cells). This naive territory of the embryo is therefore perfectly suited to assay for morphogen activity. Here we describe different methods to generate ectopic morphogen gradients, either in vivo at the animal pole of the embryo, or in vitro in animal pole explants or in aggregates of animal pole blastomeres (also named embryoid bodies)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30324453/noninvasive-two-photon-microscopy-imaging-of-mouse-retina-and-retinal-pigment-epithelium
#6
Grazyna Palczewska, Timothy S Kern, Krzysztof Palczewski
Two-photon excitation microscopy is perfectly suited for imaging deep into the retina due to its use of infrared (IR) wavelengths to excite endogenous fluorophores such as vitamin A-derived retinoids present in this tissue. Furthermore, two-photon excitation occurs only around a small focal volume, and scattered IR photons cannot excite retinal chromophores. These characteristics contribute to subcellular resolution and low noise of images obtained from deep within retinal layers. Here we describe how to customize a two-photon microscope for noninvasive imaging of the retina and retinal pigment epithelium (RPE) in the mouse eye, along with detailed instructions for mouse handling and retinal imaging, and we provide examples of mouse retinal two-photon microscopy data...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30324204/magnetic-studies-of-layer-by-layer-assembled-polyvinyl-alcohol-iron-oxide-nanofilms
#7
Ewa Mosiniewicz-Szablewska, Antonia R Clavijo, Ana P O R Castilho, Leonardo G Paterno, Marcelo A Pereira-da-Silva, Jarosław Więckowski, Maria A G Soler, Paulo C Morais
This study reports on investigation of the magnetic properties of layer-by-layer (LbL) assembled nanofilms comprising polyvinyl alcohol (PVA) and citrate-coated magnetite (cit-MAG) nanoparticles deposited onto silicon (SF sample) and glass (GF sample) substrates. DC magnetization measurements were performed over the temperature range of 4 K to 300 K, in the applied magnetic field range of ±60 kOe. The magnetic data of the as-synthesized cit-MAG nanoparticles (F sample) are also collected for comparison. The three as-fabricated samples reveal perfect superparamagnetic (SPM) behavior only around room temperature; at temperatures lower than 200 K the SPM scaling is not observed and all samples behave as interacting superparamagnetic (ISPM) materials...
October 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/30324199/dynamic-metabolic-solutions-to-the-sessile-life-style-of-plants
#8
REVIEW
Camilla Knudsen, Nethaji Janeshawari Gallage, Cecilie Cetti Hansen, Birger Lindberg Møller, Tomas Laursen
Covering: up to 2018Plants are sessile organisms. To compensate for not being able to escape when challenged by unfavorable growth conditions, pests or herbivores, plants have perfected their metabolic plasticity by having developed the capacity for on demand synthesis of a plethora of phytochemicals to specifically respond to the challenges arising during plant ontogeny. Key steps in the biosynthesis of phytochemicals are catalyzed by membrane-bound cytochrome P450 enzymes which in plants constitute a superfamily...
October 16, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/30323287/a-protein-functionalization-platform-based-on-selective-reactions-at-methionine-residues
#9
Michael T Taylor, Jennifer E Nelson, Marcos G Suero, Matthew J Gaunt
Nature has a remarkable ability to carry out site-selective post-translational modification of proteins, therefore enabling a marked increase in their functional diversity1 . Inspired by this, chemical tools have been developed for the synthetic manipulation of protein structure and function, and have become essential to the continued advancement of chemical biology, molecular biology and medicine. However, the number of chemical transformations that are suitable for effective protein functionalization is limited, because the stringent demands inherent to biological systems preclude the applicability of many potential processes2 ...
October 15, 2018: Nature
https://www.readbyqxmd.com/read/30322821/a-novel-laryngeal-palpatory-scale-lps-in-patients-with-muscle-tension-dysphonia
#10
Narges Jafari, Abolfazl Salehi, Iris Meerschman, Farzad Izadi, Abbas Ebadi, Saeed Talebian Moghadam, Seyyedeh Maryam Khoddami, Payman Dabirmoghadam, Michael Drinnan, Karolien Jordens, Evelien D'haeseleer, Kristiane Van Lierde
OBJECTIVES: Laryngeal palpation is a routine clinical method for evaluation of patients with muscle tension dysphonia (MTD). The aim of this study was to develop a new comprehensive valid and reliable "laryngeal palpatory scale" (LPS), based on psychometric criteria. METHODS: The scale items were selected based on an in-depth analysis of the literature and an expert focus group. Scale item generation and item reduction were followed by a psychometric assessment...
October 12, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/30322641/a-pdms-based-broadband-acoustic-impedance-matched-material-for-underwater-applications
#11
R-M Guillermic, M Lanoy, A Strybulevych, J H Page
Having a material that is matched in acoustic impedance with the surrounding medium is a considerable asset for many underwater acoustic applications. In this work, impedance matching is achieved by dispersing small, deeply subwavelength sized particles in a soft matrix, and the appropriate concentration is determined with the help of Coherent Potential Approximation and Waterman & Truell models. We show experimentally the validity of the models using mixtures of Polydimethylsiloxane (PDMS) and TiO2 particles...
October 3, 2018: Ultrasonics
https://www.readbyqxmd.com/read/30322544/potassium-induced-ionic-conduction-through-a-single-nanofluidic-pore-modified-with-acyclic-polyether-derivative
#12
Mubarak Ali, Ishtiaq Ahmed, Saima Nasir, Ivana Duznovic, Christof M Niemeyer, Wolfgang Ensinger
Solid-state nanofluidic pores have been attracting considerable attention of scientific community because of their structural and chemical resemblance with biological ion channels for mimicking biological processes in living systems. Compared to ion channels, synthetic nanopores exhibit high stability, control over pore dimensions (size and geometry) and their surface chemical properties can be tuned on demand. Therefore, they are considered perfect candidates to design and develop nanofluidic sensory devices by introducing a variety of functional moieties on the inner pore surface...
December 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30322540/-metal-oxide-based-heterostructures-for-gas-sensors-a-review
#13
REVIEW
Dario Zappa, Vardan Galstyan, Navpreet Kaur, Hashitha M M Munasinghe Arachchige, Orhan Sisman, Elisabetta Comini
This review focuses on the synthesis and chemical sensing characterization of metal oxide heterostructures reported since 2012. Heterostructures exhibit strong interactions between closely packed interfaces, showing superior performances compared to single structures. Surface effects appear thanks to the magnification of nanostructures' surface leading to an enhancement of surface related properties (the base of chemical sensors working mechanism). The combination of different metal oxides to form heterostructures further improves the selectivity and/or other important sensing parameters...
December 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/30321996/quad-band-plasmonic-perfect-absorber-for-visible-light-with-a-patchwork-of-silicon-nanorod-resonators
#14
Can Cao, Yongzhi Cheng
In this paper, a plasmonic perfect absorber (PPA) based on a silicon nanorod resonator (SNRR) for visible light is proposed and investigated numerically. The proposed PPA is only a two-layer nanostructure consisting of a SNRR periodic array and metal substrate. The perfect absorption mainly originates from excitation of the localized surface plasmon resonance (LSPR) mode in the SNRR structure. The absorption properties of this design can be adjusted by varying the radius ( r ) and height ( h ) of the SNRR structure...
October 12, 2018: Materials
https://www.readbyqxmd.com/read/30321961/influence-of-investigator-experience-on-reliability-of-adult-acquired-flatfoot-deformity-measurements-using-weightbearing-computed-tomography
#15
Cesar de Cesar Netto, Delaram Shakoor, Eric J Dein, Hanci Zhang, Gaurav K Thawait, Martinus Richter, James R Ficke, Lew C Schon, Shadpour Demehri
BACKGROUND: Our purpose was to assess the reliability of measurements of adult-acquired flatfoot deformity (AAFD) taken by investigators of different levels of clinical experience using weightbearing computed tomography (WBCT). METHODS: Nineteen AAFD patients underwent WBCT. Three investigators with different levels of clinical experience made AAFD measurements in axial, coronal, and sagittal planes. Intra- and interobserver reliability were assessed. Mean values for each measurement were compared between investigators...
March 12, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/30321650/-13-c-nmr-dereplication-of-garcinia-extracts-predicted-chemical-shifts-as-reliable-databases
#16
Antoine Bruguière, Séverine Derbré, Chloé Coste, Maxime Le Bot, Benjamin Siegler, Sow Tein Leong, Syazreen Nadia Sulaiman, Khalijah Awang, Pascal Richomme
Usually isolated from Garcinia (Clusiaceae) or Hypericum (Hypericaceae) species, some Polycyclic Polyprenylated AcylPhloroglucinols (PPAPs) have been recently reported as potential research tools for immunotherapy. Aiming at exploring the chemodiversity of PPAPs amongst Garcinia genus, a dereplication process suitable for such natural compounds has been developed. Although less sensitive than mass spectrometry, NMR spectroscopy is perfectly reproducible and allows stereoisomers distinction, justifying the development of 13 C-NMR strategies...
October 12, 2018: Fitoterapia
https://www.readbyqxmd.com/read/30320832/patterning-effect-mitigating-intensity-modulator-for-secure-decoy-state-quantum-key-distribution
#17
G L Roberts, M Pittaluga, M Minder, M Lucamarini, J F Dynes, Z L Yuan, A J Shields
Quantum key distribution (QKD) is a technology that allows two users to exchange cryptographic keys securely. The decoy state technique enhances the technology, ensuring keys can be shared at high bit rates over long distances with information theoretic security. However, imperfections in the implementation, known as side-channels, threaten the perfect security of practical QKD protocols. Intensity modulators are required for high-rate decoy-state QKD systems, although these are unstable and can display a side channel where the intensity of a pulse is dependent on the previous pulse...
October 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/30320763/reconstitution-of-cell-cycle-oscillations-in-microemulsions-of-cell-free-xenopus-egg-extracts
#18
Ye Guan, Shiyuan Wang, Minjun Jin, Haotian Xu, Qiong Yang
Real-time measurement of oscillations at the single-cell level is important to uncover the mechanisms of biological clocks. Although bulk extracts prepared from Xenopus laevis eggs have been powerful in dissecting biochemical networks underlying the cell-cycle progression, their ensemble average measurement typically leads to a damped oscillation, despite each individual oscillator being sustained. This is due to the difficulty of perfect synchronization among individual oscillators in noisy biological systems...
September 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/30320610/cartography-based-quality-control-of-prostate-cancer-care-a-necessary-ground-to-targeted-focal-therapy
#19
Fouad Aoun, Simone Albisinni, Roland van Velthoven
PURPOSE OF REVIEW: We summarize the evidence on accurate target definition, precise imaging, and guiding systems that are a necessary ground to targeted focal therapy. RECENT FINDINGS: Accurate target detection is based on the ability of imaging to locate and characterize precisely the tumor burden and differentiation inside the prostate. There is a clear correlation with the multiparametric MRI (mpMRI) images and the morphologic attributes of the tumor. Limitations stem from the heterogeneity and the multifocality of prostate cancer...
October 12, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/30320321/a-density-functional-theory-study-of-propylene-epoxidation-mechanism-on-ag-2-o-001-surface
#20
I Tezsevin, R A van Santen, I Onal
Propylene oxide (PO) is one of the 50 most produced chemicals according to the production volume. Environmental and economic drawbacks of conventional PO production processes necessitate new production methods. Among the new production alternatives, direct epoxidation of propylene to propylene oxide by molecular oxygen is a highly desired method and seen as the holy grail of propylene epoxidation studies. In this study, the propylene epoxidation mechanism on an Ag2O(001) surface is investigated computationally by means of density functional theory (DFT) calculations using the Vienna Ab-initio Simulation Package (VASP)...
October 15, 2018: Physical Chemistry Chemical Physics: PCCP
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