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Parkinson‘s disease

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https://www.readbyqxmd.com/read/30517862/inhibiting-stearoyl-coa-desaturase-ameliorates-%C3%AE-synuclein-cytotoxicity
#1
Benjamin M Vincent, Daniel F Tardiff, Jeff S Piotrowski, Rebecca Aron, Matthew C Lucas, Chee Yeun Chung, Helene Bacherman, YiQun Chen, Michelle Pires, Radha Subramaniam, Dimple B Doshi, Heather Sadlish, Waseem K Raja, Eric J Solís, Vikram Khurana, Bertrand Le Bourdonnec, Robert H Scannevin, Kenneth J Rhodes
The lack of disease-modifying treatments for neurodegenerative disease stems in part from our rudimentary understanding of disease mechanisms and the paucity of targets for therapeutic intervention. Here we used an integrated discovery paradigm to identify a new therapeutic target for diseases caused by α-synuclein (α-syn), a small lipid-binding protein that misfolds and aggregates in Parkinson's disease and other disorders. Using unbiased phenotypic screening, we identified a series of compounds that were cytoprotective against α-syn-mediated toxicity by inhibiting the highly conserved enzyme stearoyl-CoA desaturase (SCD)...
December 4, 2018: Cell Reports
https://www.readbyqxmd.com/read/30513043/eye-movements-in-the-morris-maze-spatial-working-memory-task-reveal-deficits-in-strategic-planning
#2
Timothy L Hodgson, Frouke Hermens, Kyla Pennington, Jade S Pickering, Gemma Ezard, Richard Clarke, Jagdish Sharma, Adrian M Owen
Analysis of eye movements can provide insights into processes underlying performance of cognitive tasks. We recorded eye movements in healthy participants and people with idiopathic Parkinson's disease during a token foraging task based on the spatial working memory component of the widely used Cambridge Neuropsychological Test Automated Battery. Participants selected boxes (using a mouse click) to reveal hidden tokens. Tokens were never hidden under a box where one had been found before, such that memory had to be used to guide box selections...
December 4, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/30511213/lower-urinary-tract-symptoms-treatment-constraints-assessment-luts-tca-a-new-tool-for-a-global-evaluation-of-neurogenic-bladder-treatments
#3
Nicolas Turmel, Pierre Lévy, Claire Hentzen, Camille Chesnel, Audrey Charlanes, Samer Sheikh-Ismael, Gérard Amarenco, Philippe Manceau
OBJECTIVES: To develop a new tool to assess constraints due to urinary treatments in neurological patients. MATERIALS AND METHODS: A prospective, monocentric study has been conducted from January to May 2017. Out-patients (multiple sclerosis, spinal cord injury, Parkinson disease) were included in a referral center if they had LUTS treatment for at least 3 months. To validate psychometric properties, we conducted a literature review, qualitative interviews, and discussion with a panel of six experts...
December 4, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/30510616/-anacardium-microcarpum-promotes-neuroprotection-dependently-of-akt-and-erk-phosphorylation-but-does-not-prevent-mitochondrial-damage-by-6-ohda
#4
Illana Kemmerich Martins, Nélson Rodrigues de Carvalho, Giulianna Echeverria Macedo, Nathane Rosa Rodrigues, Cynthia Camila Ziech, Lúcia Vinadé, Valter Menezes Barbosa Filho, Irwin Alencar Menezes, Jeferson Franco, Thaís Posser
Parkinson's disease is a degenerative and progressive illness characterized by the degeneration of dopaminergic neurons. 6-hydroxydopamine (6-OHDA) is a widespread model for induction of molecular and behavioral alterations similar to Parkinson and has contributed for testing of compounds with neuroprotective potential. The Brazilian plant Anacardium microcarpum is used in folk medicine for treatment of several illnesses; however, the knowledge about toxicology and biological effects for this plant is very rare...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30509990/synergistic-neuroprotection-by-coffee-components-eicosanoyl-5-hydroxytryptamide-and-caffeine-in-models-of-parkinson-s-disease-and-dlb
#5
Run Yan, Jie Zhang, Hye-Jin Park, Eun S Park, Stephanie Oh, Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B Stock, M Maral Mouradian
Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these brains, thereby impeding the assembly of the active trimeric holoenzyme and reducing phosphatase activity. This phosphatase deficiency contributes to the accumulation of hyperphosphorylated α-synuclein, which tends to fibrillize more than unmodified α-synuclein...
December 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/30506881/intrapallidal-injection-of-botulinum-toxin-a-recovers-gait-deficits-in-a-parkinsonian-rodent-model
#6
Adrianna R Tsang, Nagalingam Rajakumar, Mandar S Jog
AIM: Modulation of electrical activity in the subthalamic nucleus has been therapeutically effective in Parkinson's disease. Pharmacological manipulation of glutamate release from subthalamic neurons could also favourably alter basal ganglia activity to improve motor symptoms. The present study investigates the efficacy of selective suppression of hyperactive glutamatergic input from the subthalamic nucleus to the globus pallidus internal segment by botulinum toxin A (BoNT-A) in a parkinsonian model...
December 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/30506334/curcumin-restores-rotenone-induced-depressive-like-symptoms-in-animal-model-of-neurotoxicity-assessment-by-social-interaction-test-and-sucrose-preference-test
#7
Syeda Madiha, Saida Haider
Environmental toxin rotenone has been associated to with increased Parkinson's disease (PD) prevalence in population. Depression is one of the main non-motor symptoms of PD. Curcumin exhibits neuroprotective action in neurodegenerative diseases. In the study we investigated the effect of pre- and post-treatment of curcumin on rotenone-induced depressive-like behaviors and neurotransmitter alterations in rat model of PD. In pre-treatment phase rats were administered with curcumin (100 mg/kg/day, p.o.) for 2 weeks...
November 30, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30504066/medication-status-and-dual-tasking-on-turning-strategies-in-parkinson-disease
#8
M B Adamson, G Gilmore, T W Stratton, N Baktash, M S Jog
BACKGROUND: Parkinson disease (PD) patients have turning impairments that may increase fall risk. Clinics lack specialized kinematic equipment used in gait and turn analysis and require a simple method to evaluate fall risk and advise patients in turning strategy selection. OBJECTIVES: To enhance understanding of PD turning strategies and determine if turning can be assessed using a video-recording and categorization method, we compared 180-degree and 90-degree turns as a function of medication status and dual-tasking (DT)...
November 22, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30503521/parkinson-associated-snca-enhancer-variants-revealed-by-open-chromatin-in-mouse-dopamine-neurons
#9
Sarah A McClymont, Paul W Hook, Alexandra I Soto, Xylena Reed, William D Law, Samuel J Kerans, Eric L Waite, Nicole J Briceno, Joey F Thole, Michael G Heckman, Nancy N Diehl, Zbigniew K Wszolek, Cedric D Moore, Heng Zhu, Jennifer A Akiyama, Diane E Dickel, Axel Visel, Len A Pennacchio, Owen A Ross, Michael A Beer, Andrew S McCallion
The progressive loss of midbrain (MB) dopaminergic (DA) neurons defines the motor features of Parkinson disease (PD), and modulation of risk by common variants in PD has been well established through genome-wide association studies (GWASs). We acquired open chromatin signatures of purified embryonic mouse MB DA neurons because we anticipated that a fraction of PD-associated genetic variation might mediate the variants' effects within this neuronal population. Correlation with >2,300 putative enhancers assayed in mice revealed enrichment for MB cis-regulatory elements (CREs), and these data were reinforced by transgenic analyses of six additional sequences in zebrafish and mice...
November 29, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/30501375/influence-of-parkinson-s-disease-on-judging-stair-step-height-exploratory-study
#10
Núbia R da Conceição, Claudia Teixeira-Arroyo, Rodrigo Vitório, Diego Orcioli-Silva, Victor S Beretta, Priscila N de Sousa, Lilian T B Gobbi
This study investigated the effects of Parkinson's Disease (PD) on the perceptive judgment of stair step height using both exteroceptive visual and exproprioceptive judgments. We invited 14 individuals with PD and 14 neurologically healthy older adults (OA) to perform perceptual judgment tasks for first step stairway heights of 11 and 20 cm. Initially, participants performed first the exteroceptive visual judgment and then the exproprioceptive judgment in five randomized trials for each stair height. An analysis of variance for the exteroceptive visual judgment revealed no main effects or interaction between PD versus OA groups and height...
November 30, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/30501073/cross-modal-priming-effect-of-rhythm-on-visual-word-recognition-and-its-relationships-to-music-aptitude-and-reading-achievement
#11
Tess S Fotidzis, Heechun Moon, Jessica R Steele, Cyrille L Magne
Recent evidence suggests the existence of shared neural resources for rhythm processing in language and music. Such overlaps could be the basis of the facilitating effect of regular musical rhythm on spoken word processing previously reported for typical children and adults, as well as adults with Parkinson's disease and children with developmental language disorders. The present study builds upon these previous findings by examining whether non-linguistic rhythmic priming also influences visual word processing, and the extent to which such cross-modal priming effect of rhythm is related to individual differences in musical aptitude and reading skills...
November 29, 2018: Brain Sciences
https://www.readbyqxmd.com/read/30500462/dopamine-d1-receptor-activation-improves-adult-hippocampal-neurogenesis-and-exerts-anxiolytic-and-antidepressant-like-effect-via-activation-of-wnt-%C3%AE-catenin-pathways-in-rat-model-of-parkinson-s-disease
#12
Akanksha Mishra, Sonu Singh, Virendra Tiwari, Parul, Shubha Shukla
Parkinson's disease (PD) is primarily characterized by midbrain dopamine depletion. Dopamine acts through dopamine receptors (D1 to D5) to regulate locomotion, motivation, pleasure, attention, cognitive functions and formation of newborn neurons, all of which are likely to be impaired in PD. Reduced hippocampal neurogenesis associated with dopamine depletion has been demonstrated in patients with PD. However, the precise mechanism to regulate multiple steps of adult hippocampal neurogenesis by dopamine receptor(s) is still unknown...
November 27, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/30500433/functions-and-dysfunctions-of-nitric-oxide-in-brain
#13
REVIEW
Pol Picón-Pagès, Joan Garcia-Buendia, Francisco J Muñoz
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood flow and also has important roles in intracellular signaling in neurons from the regulation of the neuronal metabolic status to the dendritic spine growth. Moreover NO is able to perform post-translational modifications in proteins by the S-nitrosylation of the thiol amino acids, which is a physiological mechanism to regulate protein function. On the other hand, during aging and pathological processes the behavior of NO can turn harmful when reacts with superoxide anion to form peroxynitrite...
November 27, 2018: Biochimica et biophysica acta. Molecular basis of disease
https://www.readbyqxmd.com/read/30499488/-a-clinical-and-genetic-study-of-impulsive-compulsive-disorders-in-patients-with-parkinson-s-disease
#14
N N Shipilova, N V Titova, Z G Kokaeva, A S Fedosova, E A Klimov, E A Katunina
AIM: To evaluate the frequency and spectrum of impulsive-compulsive disorders (ICDs) in patients with Parkinson's disease (PD) without dopaminergic medication and among patients receiving dopaminergic replacement therapy, depending on personality type, genetic factors, and to determine the influence of ICDs on the development of other non-motor manifestations of the disease. MATERIAL AND METHODS: Three hundred and eighty-six consecutive patients with idiopathic PD, including untreated patients with PD (de novo) and patients receiving dopaminergic replacement therapy during one year, were examined...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30498828/mind-diet-associated-with-reduced-incidence-and-delayed-progression-of-parkinsonisma-in-old-age
#15
P Agarwal, Y Wang, A S Buchman, T M Holland, D A Bennett, M C Morris
BACKGROUND: In old age, motor impairments including parkinsonian signs are common, but treatment is lacking for many older adults. In this study, we examined the association of a diet specifically developed to promote brain health, called MIND (Mediterranean-DASH Diet Intervention for Neurodegenerative Delay), to the incidence and progression of parkinsonism in older adults. METHODS: A total of 706 Memory and Aging Project participants aged 59 -97 years and without parkinsonism at baseline were assessed annually for the presence of four parkinsonian signs using a 26-item modified version of the United Parkinson's Disease Rating Scale...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/30497781/ulk1-negatively-regulates-wnt-signaling-by-phosphorylating-dishevelled
#16
Sun-Hong Hwang, Sunhoe Bang, Kyung Shin Kang, Deborah Kang, Jongkyeong Chung
Wnt signaling pathway plays critical roles in body axes patterning, cell fate specification, cell proliferation, cell migration, stem cell maintenance, cancer development and etc. Deregulation of this pathway can be causative of cancer, metabolic disease and neurodegenerative disease such as Parkinson`s disease. Among the core components of Wnt signaling pathway, we discovered that Dishevelled (Dsh) interacts with ULK1 and is phosphorylated by ULK1. Unexpectedly, the knockdown of ULK1 elicited a marked increase in Wnt/β-catenin signaling...
November 27, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30485908/diverse-serotonin-actions-of-vilazodone-reduce-l-3-4-dihidroxyphenylalanine-induced-dyskinesia-in-hemi-parkinsonian-rats
#17
Samantha M Meadows, Melissa M Conti, Libby Gross, Nicole E Chambers, Yarden Avnor, Corinne Y Ostock, Kathryn Lanza, Christopher Bishop
BACKGROUND: The serotonergic system is a well-established modulator of l-dopa-induced dyskinesia. To date, targeting serotonin transporters or serotonin receptor subtype 1A (5-HT1A ) reduces l-dopa-induced dyskinesia in animal models; however, these strategies have failed to translate clinically. Ideally, a compound acting at both known antidyskinetic sites could optimize serotonin-mediated approaches. Vilazodone is a selective serotonin reuptake inhibitor and a partial 5-HT1A agonist approved by the U...
November 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30485556/eye-movement-disorders-and-neurological-symptoms-in-late-onset-inborn-errors-of-metabolism
#18
Lisette H Koens, Marina A J Tijssen, Fiete Lange, Bruce H R Wolffenbuttel, Alessandra Rufa, David S Zee, Tom J de Koning
Inborn errors of metabolism in adults are still largely unexplored. Despite the fact that adult-onset phenotypes have been known for many years, little attention is given to these disorders in neurological practice. The adult-onset presentation differs from childhood-onset phenotypes, often leading to considerable diagnostic delay. The identification of these patients at the earliest stage of disease is important, given that early treatment may prevent or lessen further brain damage. Neurological and psychiatric symptoms occur more frequently in adult forms...
November 28, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/30482313/parkinson-disease
#19
Samuel D Kim, Natalie E Allen, Colleen G Canning, Victor S C Fung
Parkinson disease (PD) is a complex, multisystem disorder with both neurologic and systemic nonmotor manifestations. It is neurodegenerative in nature in which disordered balance, gait, and falls are universal problems that can be present at initial diagnosis, and which progress over time. Freezing of gait is a particularly debilitating feature of PD that becomes more prevalent over time with disease progression, being present in approximately 7% after 2 years of disease and 28% after 5 years. Approximately 60% of people with PD fall each year, with around 70% of fallers falling recurrently, and some recurrent fallers falling multiple times per week...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/30482039/%C3%AE-synuclein-trafficking-in-parkinson-s-disease-insights-from-fly-and-mouse-models
#20
Jingjing Cheng, Qingqing Lu, Li Song, Margaret S Ho
Protein aggregation and accumulation are common pathological hallmarks in neurodegenerative diseases. To efficiently clear and eliminate such aggregation becomes an important cellular strategy for cell survival. Lewy bodies inclusion and aggregation of α-Synuclein (α-Syn) during the pathogenesis of Parkinson's disease (PD) serve as a good example and are potentially linked to other pathological PD features such as progressive dopaminergic neuron cell death, behavioral defects, and nonmotor symptoms like anosmia, cognitive impairment, and depression...
January 2018: ASN Neuro
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