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https://www.readbyqxmd.com/read/30088438/comprehensive-ara-c-snp-score-predicts-leukemic-cell-intracellular-ara-ctp-levels-in-pediatric-acute-myeloid-leukemia-patients
#1
Abdelrahman H Elsayed, Xueyuan Cao, Kristine R Crews, Varsha Gandhi, William Plunkett, Jeffrey E Rubnitz, Raul C Ribeiro, Stanley B Pounds, Jatinder K Lamba
AIM: Cytarabine (Ara-C), a mainstay of acute myeloid leukemia (AML) treatment, is a prodrug requiring activation to ara-CTP for its antileukemic activity. Aim of this study was to evaluate impact of genetic variants in the key genes involved in ara-C metabolism on the leukemic cell intracellular levels of ara-CTP. METHOD:  We investigated SNPs in 14 ara-C metabolic-pathway genes, for association with intracellular ara-CTP levels, in leukemic cells obtained post-initiation of cytarabine infusion in pediatric AML patients (n = 68)...
August 8, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/30058784/relative-value-of-serum-pregnancy-associated-plasma-protein-a-papp-a-and-grace-score-for-a-1-year-prognostication-a-complement-to-calculation-in-patients-with-suspected-acute-coronary-syndrome
#2
Marcin Ojrzanowski, Łukasz Figiel, Jan Z Peruga, Sonu Sahni, Jarosław D Kasprzak
BACKGROUND: The Global Registry of Acute Coronary Events (GRACE) study produced a scale for risk stratification in acute coronary syndromes (ACSs). Pregnancy-associated plasma protein A (PAPP-A) serum concentration was implicated as a marker of unstable atherosclerotic plaques. OBJECTIVES: We hypothesized that the measurement of the concentration of PAPP-A on admission may improve the stratification of cardiovascular risk in suspected ACS patients. MATERIAL AND METHODS: We studied 70 patients with chest pain suggesting ACS diagnosis on admission...
July 30, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30049431/prognostic-value-of-slox-1-level-in-acute-coronary-syndromes-based-on-thrombolysis-in-myocardial-infarction-risk-score-and-clinical-outcome
#3
Sina Mashayekhi, Mojtaba Ziaee, Alireza Garjani, Parvin Sarbakhsh, Samad Ghaffari
BACKGROUND: Biomarkers possess important diagnostic and prognostic value in acute coronary syndromes (ACSs). Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) is one of the markers involved in atherosclerotic plaque vulnerability and rupture. OBJECTIVE: This study aimed to evaluate the prognostic value of sLOX-1 through its correlation with Thrombolysis in Myocardial Infarction (TIMI) risk score and its possible association with clinical outcomes in 2 major spectrums of ACS...
July 23, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29985768/role-of-myeloperoxidase-in-early-diagnosis-of-acute-myocardial-infarction-in-patients-admitted-with-chest-pain
#4
Mohamed M Omran, Faten M Zahran, Mohamed Kadry, Arafa A M Belal, Tarek M Emran
Myeloperoxidase (MPO) is an inflammatory marker, elevated in acute coronary syndromes (ACSs), especially in acute myocardial infarction (AMI) cases. This study aimed to evaluate the diagnostic power of MPO in AMI patients. MPO, creatine kinase (CK) MB, and Troponin I (cTn I) were performed for all study patients. Area under the curves (AUCs) and 95% confidence intervals (CI); P values of baseline levels of MPO for discriminating AMI patients from noncoronary chest pain (NCCP) patients, stable angina (SA) patients, and unstable angina (UA) patients were 0...
2018: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29959663/multiple-attentional-control-settings-at-distinct-locations-without-the-confounding-of-repetition-priming
#5
Sang A Cho, Yang Seok Cho
An attentional control setting (ACS), which is based on the task goal, induces involuntary attentional capture by a stimulus possessing a target-defining feature. It is unclear whether ACSs are maintained for multiple targets defined as conjunctions of a color and location. In the present study we examined the possibility of local ACSs for dual targets defined as combinations of color and location, using different paradigms: visual search in Experiment 1, and spatial cueing in Experiment 2. In Experiment 1, a distractor captured attention only when its features matched the ACSs...
June 29, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29910582/management-of-hyperglycemia-during-and-in-the-immediate-follow-up-of-acute-coronary-syndrome
#6
REVIEW
Jamal El Ouazzani, Amine Ghalem, Ghizlane El Ouazzani, Nabila Ismaili, Noha El Ouafi
Diabetes is a serious, frequent, and insidious morbidity and mortality risk factor in patients with coronary artery disease. It has been shown that carbohydrate metabolism disorders are common in acute coronary syndromes (ACSs): 30-40% of patients have diabetes, 25-36% have an intolerance to carbohydrates, and only 30-40% have a normal carbohydrate profile. Hyperglycemia occurring either in diabetic or nondiabetic patients is strongly associated with a poor prognosis. It increases the extent of myocardial necrosis, and the risk of recurrence acute coronary syndrome and hemodynamic complications, particularly heart failure and cardiogenic shock, reflecting the importance of optimal management of glucose metabolism abnormalities...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29883423/reevaluation-of-the-acute-cystitis-symptom-score-a-self-reporting-questionnaire-part-ii-patient-reported-outcome-assessment
#7
Jakhongir F Alidjanov, Kurt G Naber, Ulugbek A Abdufattaev, Adrian Pilatz, Florian M Wagenlehner
This study aimed to reevaluate the Acute Cystitis Symptom Score (ACSS). The ACSS is a self-reporting questionnaire for the clinical diagnosis of acute uncomplicated cystitis (AC) and the assessment of symptomatic changes after therapy in female patients with AC. The part II of the present study was to reevaluate the utility of the different domains of the ACSS after therapy. The applicability of these domains in assessing changes in symptoms, as a function of time, in this population was investigated. The ACSS was evaluated in 48 female patients (mean age 31...
May 21, 2018: Antibiotics
https://www.readbyqxmd.com/read/29791953/past-and-present-a-review-of-antenatal-corticosteroids-and-recommendations-for-late-preterm-birth-steroids
#8
C Luke Dixon, Gloria Too, George R Saade, Cynthia Gyamfi-Bannerman
Since 1972, the beneficial neonatal effects of antenatal corticosteroids (ACSs) have been repeatedly demonstrated in pregnancies at risk of preterm birth before 34 weeks' gestation. While ACS utilization before 34 weeks has been high since the 1990s, knowledge gaps regarding the risks and benefits of ACS continue to exist. Recent evidence has been published regarding the benefit of ACS in the late preterm period. This review addresses the evidence and knowledge gaps for ACS use before and after 34 weeks' gestation...
May 23, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29732220/the-role-of-the-acute-cystitis-symptom-score-questionnaire-for-research-and-antimicrobial-stewardship-validation-of-the-hungarian-version
#9
András Magyar, Jakhongir Alidjanov, Adrian Pilatz, Károly Nagy, Vinodh Kumar Adithyaa Arthanareeswaran, Sándor Póth, András Bécsi, Florian M E Wagenlehner, Kurt G Naber, Péter Tenke, Béla Köves
Introduction: The Acute Cystitis Symptom Score (ACSS) is a new self-reporting tool to evaluate the symptoms of uncomplicated acute cystitis (AC) in women. The linguistic and clinical validation process of the Hungarian version used in this study may serve as a guide for the validation of the ACSS in other languages. Material and methods: In this prospective cohort study, women with AC (Patients) and those without (Controls) filled in the Hungarian ACSS version, during their visits to physician's office...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29702709/neonatal-outcomes-based-on-duration-of-exposure-to-antenatal-corticosteroids-in-indicated-preterm-deliveries
#10
Chase R Cawyer, Spencer G Kuper, Lisa A Dimperio, Alan T Tita, Joseph R Biggio, Lorie M Harper
OBJECTIVE:  To evaluate how duration of exposure to antenatal corticosteroids (ACSs) prior to delivery affects neonatal outcomes in indicated preterm deliveries. STUDY DESIGN:  This is a retrospective cohort of all indicated singleton preterm deliveries (23-34 weeks) in a single tertiary center from 2011 to 2014 comparing those who received ACS 2 to 7 days versus >7 days prior to delivery. The primary neonatal outcome was a composite of arterial cord pH < 7 or base excess ≤ 12, 5-minute Apgar ≤ 3, cardiopulmonary resuscitation, culture-proven neonatal sepsis, intraventricular hemorrhage grade III/IV, necrotizing enterocolitis, and neonatal death...
April 27, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29686594/analysis-of-the-risk-factors-associated-with-prolonged-intubation-or-reintubation-after-anterior-cervical-spine-surgery
#11
Moinay Kim, Seung Chul Rhim, Sung Woo Roh, Sang Ryong Jeon
Background: Standardized postoperative airway management is essential for patients undergoing anterior cervical spine surgery (ACSS). The paucity of clinical series evaluating these airway complications after ACSS has been resulted in a significant limitation in statistical analyses. Methods: A retrospective cohort study was performed regarding airway distress (intubation for more than 24 hours or unplanned reintubation within 7 days of operation) developed after ACSS...
April 23, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29544348/epidemiology-and-management-of-patients-with-acute-coronary-syndromes-in-contemporary-real-world-practice-evolving-trends-from-the-eyeshot-study-to-the-start-antiplatelet-registry
#12
Paolo Calabrò, Felice Gragnano, Marco di Maio, Giuseppe Patti, Emilia Antonucci, Plinio Cirillo, Paolo Gresele, Gualtiero Palareti, Vittorio Pengo, Pasquale Pignatelli, Mauro Pennacchi, Antonino Granatelli, Stefano De Servi, Leonardo De Luca, Rossella Marcucci
The epidemiology and management of patients with acute coronary syndromes (ACSs) have evolved. We aimed to describe recent demographics and therapeutic changes in the Italian ACS population. We analyzed data from 2 multicenter consecutive Italian registries (the EYESHOT [EmploYEd antithrombotic therapies in patients with acute coronary Syndromes HOspitalised in iTalian cardiac care units] and START-ANTIPLATELET registries) enrolling patients with ACS between December 2013 and June 2016. An overall population of 3756 patients with ACS was enrolled: 2585 in the EYESHOT and 1171 in the START-ANTIPLATELET...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29526331/nephrotoxicity-after-the-treatment-of-periprosthetic-joint-infection-with-antibiotic-loaded-cement-spacers
#13
Adam I Edelstein, Kamil T Okroj, Thea Rogers, Craig J Della Valle, Scott M Sporer
BACKGROUND: Treatment of periprosthetic joint infections commonly involves insertion of an antibiotic-loaded cement spacer (ACS). The risk for acute kidney injury (AKI) related to use of antibiotic spacers has not been well defined. We aimed to identify the incidence of and risk factors for AKI after placement of an ACS. METHODS: We performed a prospective cohort study of patients with an infected primary total hip or knee arthroplasty treated with ACSs with vancomycin, gentamicin, and tobramycin...
July 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29476568/asymmetric-all-metal-oxide-supercapacitor-with-superb-cycle-performance
#14
Chongyang Yang, Minqiang Sun, Hongbin Lu
Metal oxides have great potential for developing high-performance supercapacitors due to their high specific capacitances. However, achieving high energy densities while maintaining good rate capability and long cycle life has proved to be challenging. We propose herein a strategy for constructing all-metal-oxide asymmetric supercapacitors (ASCs), in which both the cathode and anode are based on metal oxides, and demonstrate their outstanding electrochemical performance. We anchored SnO2 nanoparticles on the surface of reduced graphene oxide (RGO) through Sn-O-C bonds (as the cathode of ACSs), and employed low-crystalline RGO/MoO3 nanosheets as the anode, based on the large work function difference between SnO2 and MoO3 ...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29460320/assessment-of-quality-performance-measures-in-patients-with-acute-coronary-syndromes-data-from-the-portuguese-registry-of-acute-coronary-syndromes-proacs-a-nationwide-registry
#15
Ana Teresa Timóteo, Jorge Mimoso
RATIONAL, AIMS, AND OBJECTIVES: Registries are a powerful tool to assess specific performance measurements and quality of care in acute coronary syndromes (ACSs). In Portugal, ProACS is a nationwide registry of ACS that has been active for the past 15 years, and our objective was to assess specific quality indicators for the treatment of ACS. METHODS: Descriptive analysis of data from ProACS registry in specific quality indicators previously defined by international scientific societies...
April 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29434722/analysis-of-long-non-coding-rna-expression-profiles-identifies-functional-lncrnas-associated-with-the-progression-of-acute-coronary-syndromes
#16
Yingjie Lu, Xiangwei Meng, Lifeng Wang, Xiaoyun Wang
It has been demonstrated that long non-coding RNAs (lncRNAs) are important in the gene regulatory network and their dysregulated expression has been implicated in cardiovascular disease. However, little is known regarding lncRNA expression patterns and their function in the progression of acute coronary syndromes (ACSs). In the present study, the expression profiles of lncRNAs from 52 patients with ACS were analyzed by re-annotating existing microarray data. The lncRNA expression profiles in the two distinct clinical entities of ACS, myocardial infarction (MI) and unstable angina (UA), were examined...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29329796/the-evolving-face-of-myocardial-reperfusion-in-acute-coronary-syndromes-a-primer-for-the-internist
#17
REVIEW
R Jay Widmer, Peter M Pollak, Malcolm R Bell, Bernard J Gersh, Nandan S Anavekar
Acute coronary syndromes (ACSs) account for a large proportion of disease burden in the United States and worldwide, and our understanding of ACS management continues to evolve. In this review we take a practical approach to evaluating and treating a patient with ACS, focusing on the optimal timing and methods of coronary reperfusion. Beginning with initial assessment and risk stratification, a provider managing the patient with ACS must be able to expeditiously decide on and implement the correct guideline-directed pathway to optimize outcomes...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29324765/brassinosteroids-regulate-root-growth-by-controlling-reactive-oxygen-species-homeostasis-and-dual-effect-on-ethylene-synthesis-in-arabidopsis
#18
Bingsheng Lv, Huiyu Tian, Feng Zhang, Jiajia Liu, Songchong Lu, Mingyi Bai, Chuanyou Li, Zhaojun Ding
The brassinosteroids (BRs) represent a class of phytohormones, which regulate numerous aspects of growth and development. Here, a det2-9 mutant defective in BR synthesis was identified from an EMS mutant screening for defects in root length, and was used to investigate the role of BR in root development in Arabidopsis. The det2-9 mutant displays a short-root phenotype, which is result from the reduced cell number in root meristem and decreased cell size in root maturation zone. Ethylene synthesis is highly increased in the det2-9 mutant compared with the wild type, resulting in the hyper-accumulation of ethylene and the consequent inhibition of root growth...
January 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29209328/antibodies-against-myc-associated-zinc-finger-protein-an-independent-marker-in-acute-coronary-syndrome
#19
Diana Ernst, Christian Widera, Niklas T Baerlecken, Wolfgang Schlumberger, Cornelia Daehnrich, Reinhold E Schmidt, Katja Gabrysch, Lars Wallentin, Torsten Witte
Introduction: Atherosclerosis is considered the pathophysiology underlying cardiovascular (CVD), cerebrovascular, and peripheral vascular diseases. Evidence supporting an autoimmune component is emerging, with imaging studies correlating MYC-associated zinc finger protein antibody (MAZ-Ab) optical density (OD) with plaque activity. This study compares MAZ-Ab OD on ELISA testing among patients presenting with acute coronary syndromes (ACSs) to healthy controls and investigates the association of MAZ-Ab to traditional CVD risk factors...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29200800/the-acceptance-of-cosmetic-surgery-scale-confirmatory-factor-analyses-and-validation-among-serbian-adults
#20
Marko Jovic, Marcos Sforza, Milan Jovanovic, Marija Jovic
We examined the validity of the Serbian version of the Acceptance of Cosmetic Surgery Scale (ACSS; Henderson-King and Henderson-King 2005). A total of 622 Serbian adults completed the ACSS, along with Serbian translations of measures for the discrepancy between actual body weight and ideal body weight, body appreciation, sociocultural attitudes toward appearance, and demographics. Confirmatory factor analyses were conducted to compare how different ACSS models fitted the collected data. A three-factor model provided the best fit to the data relative to two- and one-factor models...
2017: Current Psychology
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