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https://www.readbyqxmd.com/read/30504788/high-density-huh7-5-cell-hollow-fiber-bioreactor-culture-for-high-yield-production-of-hepatitis-c-virus-and-studies-of-antivirals
#1
Anne F Pihl, Anna F Offersgaard, Christian K Mathiesen, Jannick Prentoe, Ulrik Fahnøe, Henrik Krarup, Jens Bukh, Judith M Gottwein
Chronic hepatitis C virus (HCV) infection poses a serious global public health burden. Despite the recent development of effective treatments there is a large unmet need for a prophylactic vaccine. Further, antiviral resistance might compromise treatment efficiency in the future. HCV cell culture systems are typically based on Huh7 and derived hepatoma cell lines cultured in monolayers. However, efficient high cell density culture systems for high-yield HCV production and studies of antivirals are lacking. We established a system based on Huh7...
November 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30503535/cooperative-induction-of-ordered-peptide-and-fatty-acid-aggregates
#2
Radoslaw Bomba, Witek Kwiatkowski, Antoni Sánchez-Ferrer, Roland Riek, Jason Greenwald
Interactions between biological membranes and disease-associated amyloids are well documented, and their prevalence suggests that an inherent affinity exists between these molecular assemblies. Our interest in the molecular origins of life have led us to investigate the nature of such interactions in the context of their molecular predecessors (i.e., vesicle-forming amphiphiles and small peptides). Under certain conditions, amyloidogenic peptides or fatty acids are each able to form ordered structures on their own; however, we report here on their cooperative assembly into novel, to our knowledge, highly ordered structures...
November 10, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/30502013/a-comparison-between-two-collagen-nerve-conduits-and-nerve-autograft-a-rat-model-of-motor-nerve-regeneration
#3
Eliana B Saltzman, Jordan C Villa, Stephen B Doty, Joseph H Feinberg, Steve K Lee, Scott W Wolfe
PURPOSE: To compare recovery in a rat model of sciatic nerve injury using a novel polyglycolic acid (PGA) conduit, which contains collagen fibers within the tube, as compared with both a hollow collagen conduit and nerve autograft. We hypothesize that a conduit with a scaffold will provide improved nerve regeneration over hollow conduits and demonstrate no significant differences when compared with autograft. METHODS: A total of 72 Sprague-Dawley rats were randomized into 3 experimental groups, in which a unilateral 10-mm sciatic defect was repaired using either nerve autograft, a hollow collagen conduit, or a PGA collagen-filled conduit...
November 27, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/30496951/neurotoxicological-effects-induced-by-up-regulation-of-mir-137-following-triclosan-exposure-to-zebrafish-danio-rerio
#4
Jinfeng Liu, Chenyan Xiang, Wenhao Huang, Jingyi Mei, Limei Sun, Yuhang Ling, Caihong Wang, Xuedong Wang, Randy A Dahlgren, Huili Wang
Triclosan (TCS) is a prevalent anthropogenic contaminant in aquatic environments and its chronic exposure can lead to a series of neurotoxic effects in zebrafish. Both qRT-PCR and W-ISH identified that TCS exposure resulted in significant up-regulation of miR-137, but downregulation of its regulatory genes (bcl11aa, MAPK6 and Runx1). These target genes are mainly associated with neurodevelopment and the MAPK signaling pathway, and showed especially high expression in the brain. After overexpression or knockdown treatments by manual intervention of miR-137, a series of abnormalities were induced, such as ventricular abnormality, bent spine, yolk cyst, closure of swim sac and venous sinus hemorrhage...
November 22, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/30496466/amikacin-dosing-for-mdr-tuberculosis-a-systematic-review-to-establish-or-revise-the-current-recommended-dose-for-tuberculosis-treatment
#5
Marieke G G Sturkenboom, Noviana Simbar, Onno W Akkerman, Samiksha Ghimire, Mathieu S Bolhuis, Jan-Willem C Alffenaar
Background: Amikacin has been used for over 40 years in multidrug resistant tuberculosis (MDR-TB), but there is still debate on the right dose. The aim of this review was to search relevant pharmacokinetic (PK) and pharmacodynamic (PD) literature for the optimal dose and dosing frequency of amikacin in MDR-TB regimens trying to optimize efficacy while minimizing toxicity. Methods: A systematic review on the value of amikacin as second-line drug in the treatment of MDR-TB was performed...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496465/efficacy-versus-hepatotoxicity-of-high-dose-rifampin-pyrazinamide-and-moxifloxacin-to-shorten-tuberculosis-therapy-duration-there-is-still-fight-in-the-old-warriors-yet
#6
Shashikant Srivastava, Devyani Deshpande, Gesham Magombedze, Tawanda Gumbo
Background: One approach that could increase the efficacy and reduce the duration of antituberculosis therapy is pharmacokinetics/pharmacodynamics-based optimization of doses. However, this could increase toxicity. Methods: We mimicked the concentration-time profiles achieved by human equivalent doses of moxifloxacin 800 mg/day, rifampin 1800 mg/day, and pyrazinamide 4000 mg/day (high-dose regimen) vs isoniazid 300 mg/day, rifampin 600 mg/day, and pyrazinamide 2000 mg/day (standard therapy) in bactericidal and sterilizing effect studies in the hollow fiber system model of tuberculosis (HFS-TB)...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496464/transformation-morphisms-and-time-to-extinction-analysis-that-map-therapy-duration-from-preclinical-models-to-patients-with-tuberculosis-translating-from-apples-to-oranges
#7
Gesham Magombedze, Jotam G Pasipanodya, Shashikant Srivastava, Devyani Deshpande, Marianne E Visser, Emmanuel Chigutsa, Helen McIlleron, Tawanda Gumbo
Background: A major challenge in medicine is translation of preclinical model findings to humans, especially therapy duration. One major example is recent shorter-duration therapy regimen failures in tuberculosis. Methods: We used set theory mapping to develop a computational/modeling framework to map the time it takes to extinguish the Mycobacterium tuberculosis population on chemotherapy from multiple hollow fiber system model of tuberculosis (HFS-TB) experiments to that observed in patients...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496463/the-sterilizing-effect-of-intermittent-tedizolid-for-pulmonary-tuberculosis
#8
Shashikant Srivastava, Devyani Deshpande, Eric Nuermberger, Pooi S Lee, Kayle Cirrincione, Keertan Dheda, Tawanda Gumbo
Background: Linezolid exhibits remarkable sterilizing effect in tuberculosis; however, a large proportion of patients develop serious adverse events. The congener tedizolid could have a better side-effect profile, but its sterilizing effect potential is unknown. Methods: We performed a 42-day tedizolid exposure-effect and dose-fractionation study in the hollow fiber system model of tuberculosis for sterilizing effect, using human-like intrapulmonary pharmacokinetics...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496461/levofloxacin-pharmacokinetics-pharmacodynamics-dosing-susceptibility-breakpoints-and-artificial-intelligence-in-the-treatment-of-multidrug-resistant-tuberculosis
#9
Devyani Deshpande, Jotam G Pasipanodya, Stellah G Mpagama, Paula Bendet, Shashikant Srivastava, Thearith Koeuth, Pooi S Lee, Sujata M Bhavnani, Paul G Ambrose, Guy Thwaites, Scott K Heysell, Tawanda Gumbo
Background: Levofloxacin is used for the treatment of multidrug-resistant tuberculosis; however the optimal dose is unknown. Methods: We used the hollow fiber system model of tuberculosis (HFS-TB) to identify 0-24 hour area under the concentration-time curve (AUC0-24) to minimum inhibitory concentration (MIC) ratios associated with maximal microbial kill and suppression of acquired drug resistance (ADR) of Mycobacterium tuberculosis (Mtb). Levofloxacin-resistant isolates underwent whole-genome sequencing...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496460/d-cycloserine-pharmacokinetics-pharmacodynamics-susceptibility-and-dosing-implications-in-multidrug-resistant-tuberculosis-a-faustian-deal
#10
Devyani Deshpande, Jan-Willem C Alffenaar, Claudio U Köser, Keertan Dheda, Moti L Chapagain, Noviana Simbar, Thomas Schön, Marieke G G Sturkenboom, Helen McIlleron, Pooi S Lee, Thearith Koeuth, Stellah G Mpagama, Sayera Banu, Suporn Foongladda, Oleg Ogarkov, Suporn Pholwat, Eric R Houpt, Scott K Heysell, Tawanda Gumbo
Background: d-cycloserine is used to treat multidrug-resistant tuberculosis. Its efficacy, contribution in combination therapy, and best clinical dose are unclear, also data on the d-cycloserine minimum inhibitory concentration (MIC) distributions is scant. Methods: We performed a systematic search to identify pharmacokinetic and pharmacodynamic studies performed with d-cycloserine. We then performed a combined exposure-effect and dose fractionation study of d-cycloserine in the hollow fiber system model of tuberculosis (HFS-TB)...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496459/gatifloxacin-pharmacokinetics-pharmacodynamics-based-optimal-dosing-for-pulmonary-and-meningeal-multidrug-resistant-tuberculosis
#11
Devyani Deshpande, Jotam G Pasipanodya, Shashikant Srivastava, Paula Bendet, Thearith Koeuth, Sujata M Bhavnani, Paul G Ambrose, Wynand Smythe, Helen McIlleron, Guy Thwaites, Mourad Gumusboga, Armand Van Deun, Tawanda Gumbo
Background: Gatifloxacin is used for the treatment of multidrug-resistant tuberculosis (MDR-TB). The optimal dose is unknown. Methods: We performed a 28-day gatifloxacin hollow-fiber system model of tuberculosis (HFS-TB) study in order to identify the target exposures associated with optimal kill rates and resistance suppression. Monte Carlo experiments (MCE) were used to identify the dose that would achieve the target exposure in 10000 adult patients with meningeal or pulmonary MDR-TB...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496457/ethionamide-pharmacokinetics-pharmacodynamics-derived-dose-the-role-of-mics-in-clinical-outcome-and-the-resistance-arrow-of-time-in-multidrug-resistant-tuberculosis
#12
Devyani Deshpande, Jotam G Pasipanodya, Stellah G Mpagama, Shashikant Srivastava, Paula Bendet, Thearith Koeuth, Pooi S Lee, Scott K Heysell, Tawanda Gumbo
Background: Ethionamide is used to treat multidrug-resistant tuberculosis (MDR-TB). The antimicrobial pharmacokinetics/pharmacodynamics, the contribution of ethionamide to the multidrug regimen, and events that lead to acquired drug resistance (ADR) are unclear. Methods: We performed a multidose hollow fiber system model of tuberculosis (HFS-TB) study to identify the 0-24 hour area under the concentration-time curve (AUC0-24) to minimum inhibitory concentration (MIC) ratios that achieved maximal kill and ADR suppression, defined as target exposures...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496456/multiparameter-responses-to-tedizolid-monotherapy-and-moxifloxacin-combination-therapy-models-of-children-with-intracellular-tuberculosis
#13
Devyani Deshpande, Shashikant Srivastava, Eric Nuermberger, Thearith Koeuth, Katherine R Martin, Kayle N Cirrincione, Pooi S Lee, Tawanda Gumbo
Background: Children are often neglected during early development of antituberculosis agents, and most receive treatment after it is first tested in adults. However, very young children have tuberculosis that differs in many respects from adult cavitary pneumonia and could have different toxicity profiles to drugs. Linezolid is effective against intracellular tuberculosis, a common manifestation in young children. However, linezolid has considerable toxicity due to inhibition of mitochondrial enzymes...
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30496455/pharmacokinetic-pharmacodynamic-background-and-methods-and-scientific-evidence-base-for-dosing-of-second-line-tuberculosis-drugs
#14
Tawanda Gumbo, Jan-Willem C Alffenaar
A World Health Organization workshop systematically examined the evidence base for dosing second-line tuberculosis drugs, identifying knowledge gaps. To fill these in, pharmacokinetics/pharmacodynamics, Monte Carlo experiments, and artificial intelligence algorithms were used in hollow-fiber model studies and clinical data analyses.
November 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/30486297/antiresonant-reflecting-guidance-and-mach-zender-interference-in-cascaded-hollow-core-fibers-for-multi-parameter-sensing
#15
Maoxiang Hou, Jun He, Xizhen Xu, Ziliang Li, Zhe Zhang, Kuikui Guo, Shuai Ju, Yiping Wang
We propose and demonstrate a cascaded hollow-core fiber (HCF) device for multi-parameter sensing based on the combination of antiresonant reflecting guidance (ARRG) and Mach-Zender interference (MZI). The device was fabricated by splicing two sections of HCF together. Two sets of fringes, which have different free spectral ranges, were generated from ARRG and MZI, respectively, and were aliasing in the transmission spectrum. The two sets of fringes were then separated using a band pass filter and a Gaussian fitting technique...
November 26, 2018: Sensors
https://www.readbyqxmd.com/read/30485660/nanofibers-for-biomedical-and-healthcare-applications
#16
REVIEW
Rahimeh Rasouli, Ahmed Barhoum, Mikhael Bechelany, Alain Dufresne
Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue-engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems...
November 28, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/30480423/self-supported-feco2s4-nanotube-arrays-as-binder-free-cathode-for-lithium-sulfur-batteries
#17
Bingshu Guo, Sateesh Bandaru, Chunlong Dai, Hao Chen, Youquan Zhang, Qiuju Xu, Shu-Juan Bao, Mingyang Chen, Maowen Xu
Inhibiting shuttle effect, buffering volume expansion and improving utilization of sulfur have been the three strategic points for developing a high-performance lithium-sulphur (Li-S) battery. Driven by this background, a flexible sulfur host material composed of FeCo2S4 nanotube arrays grown on the surface of carbon cloth is designed for binder-free cathode of the Li-S battery through two-step hydrothermal methods. Among the rest, the interconnected carbon fiber skeleton of the composite electrode ensures the basic electrical conductivity, whereas the FeCo2S4 nanotube arrays not only boost the electron and electrolyte transfer but also inhibit the dissolution of polysulfide due to their strong chemical adsorption...
November 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30475594/a-hollow-core-photonics-crystal-fiber-based-miniaturized-sensor-for-detection-of-aggregation-induced-emission-molecules
#18
Huifang Chen, Qinjian Jiang, Yanqing Qiu, Xuechun Chen, Bo Fan, Yi Wang, Dongning Wang
A miniature sensor for detection of aggregation-induced emission (AIE) molecule is proposed in this work. The sensing head is fabricated by use of hollow core photonic crystal fiber with a core diameter of about 4.8 μm. The cladding holes are sealed by fusion splicing technique while the central hole remains open to allow the filtration of solution with AIE molecules. When the solution is excited by ultraviolet lamp, the fluorescence light is received by a fiber optic spectrometer. The fluorescence intensity is associated with the concentration of AIE molecules and the infiltrated core length...
November 26, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/30470035/laser-frequency-stabilization-and-spectroscopy-at-2051-nm-using-a-compact-co-2-filled-kagome-hollow-core-fiber-gas-cell-system
#19
E Anne Curtis, Thomas Bradley, Geoffrey P Barwood, Christopher S Edwards, Natalie V Wheeler, Richard Phelan, David J Richardson, Marco N Petrovich, Patrick Gill
We describe a compact, all fiber, frequency stabilized diode laser system at 2051 nm using CO2 gas-filled Kagome Hollow Core Fiber (HCF), capable of tuning continuously over four transitions in 12 C16 O2 : R(24), R(26), R(28), and R(30). This laser system has been designed for use in future space-based atmospheric monitoring using differential absorption lidar (DIAL). The fully spliced Kagome HCF gas cell is filled to 2 kPa CO2 partial pressure and we compare the observed CO2 lineshape features with those calculated using HITRAN, to quantify the properties of the CO2 -filled fiber cell...
October 29, 2018: Optics Express
https://www.readbyqxmd.com/read/30469900/excitation-of-higher-order-modes-in-optofluidic-photonic-crystal-fiber
#20
Andrei Ruskuc, Philipp Koehler, Marius A Weber, Ana Andres-Arroyo, Michael H Frosz, Philip St J Russell, Tijmen G Euser
Higher-order modes up to LP33 are controllably excited in water-filled kagomé- and bandgap-style hollow-core photonic crystal fibers (HC-PCF). A spatial light modulator is used to create amplitude and phase distributions that closely match those of the fiber modes, resulting in typical launch efficiencies of 10-20% into the liquid-filled core. Modes, excited across the visible wavelength range, closely resemble those observed in air-filled kagomé HC-PCF and match numerical simulations. Mode indices are obtained by launching plane-waves at specific angles onto the fiber input-face and comparing the resulting intensity pattern to that of a particular mode...
November 12, 2018: Optics Express
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