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JOURNAL ARTICLE
Fabio Scarpa, Stefano Pascarella, Alessandra Ciccozzi, Marta Giovanetti, Ilenia Azzena, Chiara Locci, Marco Casu, Pier Luigi Fiori, Miriana Quaranta, Eleonora Cella, Daria Sanna, Massimo Ciccozzi
The severe acute respiratory syndrome coronavirus 2 EG.5 lineage is the latest variant under monitoring, and it is generating significant concern due to its recent upward trend in prevalence. Our aim was to gain insights into this emerging lineage and offer insights into its actual level of threat. Both genetic and structural data indicate that this novel variant presently lacks substantial evidence of having a high capacity for widespread transmission. Their viral population sizes expanded following a very mild curve and peaked several months after the earliest detected sample...
September 2023: Journal of Medical Virology
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JOURNAL ARTICLE
Fabio Scarpa, Liliana Bazzani, Marta Giovanetti, Alessandra Ciccozzi, Francesca Benedetti, Davide Zella, Daria Sanna, Marco Casu, Alessandra Borsetti, Eleonora Cella, Stefano Pascarella, Antonello Maruotti, Massimo Ciccozzi
The COVID-19 pandemic has not only strained healthcare systems in Africa but has also intensified the impact of emerging and re-emerging diseases. Specifically in Equatorial Guinea, mirroring the situation in other African countries, unique zoonotic outbreaks have occurred during this challenging period. One notable resurgence is Marburg virus disease (MVD), which has further burdened the already fragile healthcare system. The re-emergence of the Marburg virus amid the COVID-19 pandemic is believed to stem from a probable zoonotic spill-over, although the precise transmission routes remain uncertain...
August 11, 2023: Viruses
#3
JOURNAL ARTICLE
David Cella, Kimberly Kelly, Anna de la Motte, Farah Toublan, Bhavik J Pandya, Manasee V Shah, Thomas W LeBlanc
The symptoms of acute myeloid leukemia (AML) and its treatment can negatively impact patient functioning and quality of life. Through concept elicitation interviews, we sought to evaluate the experience of patients with AML in remission following hematopoietic stem cell transplant (HSCT). Thirty patients with AML in remission post-HSCT, and eight clinicians with experience treating such patients, were asked to identify symptoms and impacts associated with AML and/or its treatment. The findings were used to develop an AML conceptual disease model to reflect the experience of these patients...
June 8, 2023: Leukemia & Lymphoma
#4
JOURNAL ARTICLE
Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karch
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer's disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukodystrophy, Nasu-Hakola disease (NHD). Despite extensive investigation, the role of TREM2 in NHD pathogenesis remains poorly understood. Here, we investigate the mechanisms by which a homozygous stop-gain TREM2 mutation (p.Q33X) contributes to NHD. Induced pluripotent stem cell (iPSC)-derived microglia (iMGLs) were generated from two NHD families: three homozygous TREM2 p...
April 28, 2023: Acta Neuropathologica
#5
JOURNAL ARTICLE
Wilsandrei Cella, Isabelle Luiz Rahal, Gabriela Catuzo Canônico Silva, Ezilda Jacomassi, Ranulfo Piau Junior, José Eduardo Gonçalves, Daniela Dib Gonçalves, Zilda Cristiani Gazim
Around the world, the main problems of livestock are caused by ectoparasites, however, commercial acaracide are toxic to the environment and detrimental to One Health. Therefore, research has increasingly focused on development of natural products as alternatives for tick control. The purpose of this study was to evaluate the larvicidal effect on Rhipicephalus (Boophilus) microplus, through use of essential oils (EOs) extracted from the leaves, flower buds and stems of Tetradenia riparia. The chemical composition of these EOs was determined through gas chromatography coupled to mass spectrometry (GC-MS)...
2023: Brazilian Journal of Veterinary Parasitology
#6
JOURNAL ARTICLE
Fabia Filipello, Shih-Feng You, Rita Martinez, Olena Korvatska, Wendy H Raskind, Sidhartha Mahali, Laura Ghezzi, Beatty Wandy, Marina Cella, Laura Piccio, Celeste M Karch
BACKGROUND: Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia in the adult brain. Homozygous loss of function TREM2 variants cause a rare leukodystrophy characterized by bone cysts and early-onset dementia, Nasu-Hakola disease (NHD). However, despite intense investigation, the role of TREM2 in NHD pathogenesis remains poorly understood. METHOD: Here, we investigated the mechanisms by which a homozygous stop-gain TREM2 variant (Q33X), which leads to a truncated TREM2 transcript, contributes to disease pathology in NHD...
December 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#7
JOURNAL ARTICLE
P Ryska, O Slezak, A Eklund, J Salzer, J Malm, J Zizka
BACKGROUND AND PURPOSE: Systematic analysis of angulation-related variability of idiopathic normal pressure hydrocephalus imaging biomarkers has not been published yet. Our aim was to evaluate the variability of these radiologic biomarkers with respect to imaging plane angulation. MATERIALS AND METHODS: Eighty subjects (35 with clinically confirmed idiopathic normal pressure hydrocephalus and 45 age- and sex-matched healthy controls) were prospectively enrolled in a 3T brain MR imaging study...
July 2021: AJNR. American Journal of Neuroradiology
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JOURNAL ARTICLE
Jahnavi Aluri, Alicia Bach, Saara Kaviany, Luana Chiquetto Paracatu, Maleewan Kitcharoensakkul, Magdalena A Walkiewicz, Christopher D Putnam, Marwan Shinawi, Nermina Saucier, Elise M Rizzi, Michael T Harmon, Molly P Keppel, Michelle Ritter, Morgan Similuk, Elaine Kulm, Michael Joyce, Adriana A de Jesus, Raphaela Goldbach-Mansky, Yi-Shan Lee, Marina Cella, Peggy L Kendall, Mary C Dinauer, Jeffrey J Bednarski, Christina Bemrich-Stolz, Scott W Canna, Shirley M Abraham, Matthew M Demczko, Jonathan Powell, Stacie M Jones, Amy M Scurlock, Suk See De Ravin, Jack J Bleesing, James A Connelly, V Koneti Rao, Laura G Schuettpelz, Megan A Cooper
Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the human immune response. We identified 6 unrelated males with neutropenia, infections, lymphoproliferation, humoral immune defects, and in some cases bone marrow failure associated with 3 different variants in the X-linked gene TLR8, encoding the endosomal Toll-like receptor 8 (TLR8)...
May 6, 2021: Blood
#9
JOURNAL ARTICLE
Alexandra Mills, Elizabeth Bearce, Rachael Cella, Seung Woo Kim, Megan Selig, Sangmook Lee, Laura Anne Lowery
Wolf-Hirschhorn Syndrome (WHS) is a human developmental disorder arising from a hemizygous perturbation, typically a microdeletion, on the short arm of chromosome four. In addition to pronounced intellectual disability, seizures, and delayed growth, WHS presents with a characteristic facial dysmorphism and varying prevalence of microcephaly, micrognathia, cartilage malformation in the ear and nose, and facial asymmetries. These affected craniofacial tissues all derive from a shared embryonic precursor, the cranial neural crest (CNC), inviting the hypothesis that one or more WHS-affected genes may be critical regulators of neural crest development or migration...
2019: Frontiers in Physiology
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JOURNAL ARTICLE
Manuel J Steinbauer, John-Arvid Grytnes, Gerald Jurasinski, Aino Kulonen, Jonathan Lenoir, Harald Pauli, Christian Rixen, Manuela Winkler, Manfred Bardy-Durchhalter, Elena Barni, Anne D Bjorkman, Frank T Breiner, Sarah Burg, Patryk Czortek, Melissa A Dawes, Anna Delimat, Stefan Dullinger, Brigitta Erschbamer, Vivian A Felde, Olatz Fernández-Arberas, Kjetil F Fossheim, Daniel Gómez-García, Damien Georges, Erlend T Grindrud, Sylvia Haider, Siri V Haugum, Hanne Henriksen, María J Herreros, Bogdan Jaroszewicz, Francesca Jaroszynska, Robert Kanka, Jutta Kapfer, Kari Klanderud, Ingolf Kühn, Andrea Lamprecht, Magali Matteodo, Umberto Morra di Cella, Signe Normand, Arvid Odland, Siri L Olsen, Sara Palacio, Martina Petey, Veronika Piscová, Blazena Sedlakova, Klaus Steinbauer, Veronika Stöckli, Jens-Christian Svenning, Guido Teppa, Jean-Paul Theurillat, Pascal Vittoz, Sarah J Woodin, Niklaus E Zimmermann, Sonja Wipf
Globally accelerating trends in societal development and human environmental impacts since the mid-twentieth century 1-7 are known as the Great Acceleration and have been discussed as a key indicator of the onset of the Anthropocene epoch 6 . While reports on ecological responses (for example, changes in species range or local extinctions) to the Great Acceleration are multiplying 8, 9 , it is unknown whether such biotic responses are undergoing a similar acceleration over time. This knowledge gap stems from the limited availability of time series data on biodiversity changes across large temporal and geographical extents...
April 2018: Nature
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JOURNAL ARTICLE
David J Straus, Paul A Hamlin, Matthew J Matasar, Maria Lia Palomba, Pamela R Drullinsky, Andrew D Zelenetz, John F Gerecitano, Ariela Noy, Audrey M Hamilton, Rebecca Elstrom, Brett Wegner, Katy Wortman, David Cella
The standard treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL) in frail elderly patients has not been established. A variation was made on rituximab (R), cyclophosphamide (C), etoposide (E), procarbazine and prednisone (P), substituting vorinostat (V) for procarbazine. Patients ≥aged 60 years with relapsed/refractory DLBCL, not candidates for autologous stem cell transplantation, were treated R-CVEP [R 375 mg/m(2) intravenously (IV), day 1; C 600 mg/m(2) IV days 1, 8: E 70 mg/m(2) IV day 1, 140 mg/m(2) days 2, 3 orally (PO); V (300 vs...
March 2015: British Journal of Haematology
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JOURNAL ARTICLE
Brittany R Tielbur, Donna E Rice Cella, Amanda Currie, Jonathan D Roach, Bryan Mattingly, Jack Boone, Christina Watwood, Ann McGauran, Howard S Kirshner, P David Charles
Disjointed patient care is a well-documented problem in health care systems, often stemming from poor communication between providers, services, and follow-up care resources. A multidisciplinary discharge huddle, augmented with cellular and tablet technology, was implemented on the Neurology Stroke Service to facilitate multidisciplinary communication, improve transition of patients, and increase referrals into affiliated follow-up care. After initiating the huddle, patient length of stay decreased by 1.4 days (25%), patient flow into continuum partners increased by 10%, and the number of patients going without services after their hospital stay decreased by more than 12%...
January 2015: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
#13
JOURNAL ARTICLE
Jill M Cyranowski, Nicholas Zill, Rita Bode, Zeeshan Butt, Morgen A R Kelly, Paul A Pilkonis, John M Salsman, David Cella
OBJECTIVE: The quality of our daily social interactions-including perceptions of support, feelings of loneliness, and distress stemming from negative social exchanges-influence physical health and well-being. Despite the importance of social relationships, brief yet precise unidimensional scales that assess key aspects of social relationship quality are lacking. As part of the National Institute of Health (NIH) Toolbox for the Assessment of Neurological and Behavioral Function, we developed brief self-report scales designed to assess aspects of social support, companionship, and social distress across age cohorts...
March 2013: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
#14
JOURNAL ARTICLE
Elena De Momi, Chiara Caborni, Francesco Cardinale, Laura Castana, Giuseppe Casaceli, Massimo Cossu, Luca Antiga, Giancarlo Ferrigno
In StereoElectroEncephaloGraphy (SEEG) procedures, intracerebral electrodes are implanted in order to identify the epileptogenic zone in drug-resistant epileptic patients. This paper presents an automatic multitrajectory planner that computes the best trajectory in terms of distance from vessels and guiding screws angle, once the candidate entry and target regions are quickly and roughly defined. The planning process is designed also to spare some brain structures, such as cella media and trigone of the lateral ventricles and brain stem...
April 2013: IEEE Transactions on Bio-medical Engineering
#15
JOURNAL ARTICLE
Karel Otero, Masahiro Shinohara, Haibo Zhao, Marina Cella, Susan Gilfillan, Angela Colucci, Roberta Faccio, F Patrick Ross, Steve L Teitelbaum, Hiroshi Takayanagi, Marco Colonna
TREM2 is an immunoreceptor expressed on osteoclasts (OC) and microglia that transmits intracellular signals through the adaptor DAP12. Individuals with genetic mutations inactivating TREM2 or DAP12 develop the Nasu-Hakola disease (NHD) with cystic-like lesions of the bone and brain demyelination that lead to fractures and presenile dementia. The mechanisms of this disease are poorly understood. In this study, we report that TREM2-deficient mice have an osteopenic phenotype reminiscent of NHD. In vitro, lack of TREM2 impairs proliferation and β-catenin activation in osteoclast precursors (OcP) in response to M-CSF...
March 15, 2012: Journal of Immunology
#16
JOURNAL ARTICLE
Luigi Cella, Aldo Oppici, Mariacristina Arbasi, Mauro Moretto, Massimo Piepoli, Daniele Vallisa, Adriano Zangrandi, Camilla Di Nunzio, Luigi Cavanna
PURPOSE: Bisphosphonate - related osteonecrosis of the JAW (BRONJ) is a well known side effect of bisphosphonate therapies in oncologic and non oncologic patients. Since to date no definitive consensus has been reached on the treatment of BRONJ, novel strategies for the prevention, risk reduction and treatment need to be developed. We report a 75 year old woman with stage 3 BRONJ secondary to alendronate and pamidronate treatment of osteoporosis. The patient was unresponsive to recommended treatment of the disease, and her BRONJ was worsening...
August 17, 2011: Head & Face Medicine
#17
JOURNAL ARTICLE
Maria Teresa Sartori, Simone Cesaro, Mattia Peruzzo, Chiara Messina, Graziella Saggiorato, Elisabetta Calore, Marta Pillon, Stefania Varotto, Luca Spiezia, Giuseppe Cella
BACKGROUND: Veno-occlusive disease (VOD) is a major complication following hematopoietic stem cell transplantation (HSCT). Its diagnosis is based on clinical criteria, which have a limited sensitivity. Increased plasminogen activator inhibitor-1 (PAI-1) levels have been suggested as a marker of VOD. We aimed to prospectively evaluate how the fibrinolytic parameters behaved to discriminate VOD from other liver disorders occurring after HSCT in a pediatric population. PROCEDURES: A total of 195 HSCT were performed on 161 children and VOD complicated 11 cases (6...
May 2012: Pediatric Blood & Cancer
#18
JOURNAL ARTICLE
Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli
Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia. Results of transplant in thalassemia and in sickle cell anemia have steadily improved over the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. From 2004 through 2009, 145 consecutive patients with thalassemia and sickle cell anemia, ethnically heterogeneous from Mediterranean and Middle East countries, were given HSCT in the International Center for Transplantation in Thalassemia and Sickle Cella Anemia in Rome...
December 26, 2009: Mediterranean Journal of Hematology and Infectious Diseases
#19
JOURNAL ARTICLE
John R Wingard, I-Chan Huang, Kathleen A Sobocinski, Michael A Andrykowski, David Cella, J Douglas Rizzo, Marianne Brady, Mary M Horowitz, Michelle M Bishop
Hematopoietic cell transplantation (HCT) is an intensive treatment for hematologic malignancies that has the potential to cure disease or prolong life, but also to impair quality of life for survivors. Earlier studies have suggested that various factors are associated with physical and mental health after HCT. In this study, we evaluated demographic and clinical factors before and after HCT and selected psychosocial factors after HCT, exploring their association with self-reported physical and mental health...
December 2010: Biology of Blood and Marrow Transplantation
#20
JOURNAL ARTICLE
Lucrecia Cella Pizarro, Alejandro J Bisigato
BACKGROUND AND AIMS: The growth-differentiation balance hypothesis (GDBH) states that there is a physiological trade-off between growth and secondary metabolism and predicts a parabolic effect of resource availability (such as water or nutrients) on secondary metabolite production. To test this hypothesis, the response of six Patagonian Monte species (Jarava speciosa, Grindelia chiloensis, Prosopis alpataco, Bougainvillea spinosa, Chuquiraga erinacea and Larrea divaricata) were investigated in terms of total biomass and resource allocation patterns in response to a water gradient...
August 2010: Annals of Botany
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