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Early gallbladder cancer

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https://www.readbyqxmd.com/read/30304546/erbb2-and-kras-alterations-mediate-response-to-egfr-inhibitors-in-early-stage-gallbladder-cancer
#1
Prajish Iyer, Shailesh V Shrikhande, Malika Ranjan, Asim Joshi, Nilesh Gardi, Ratnam Prasad, Bhasker Dharavath, Rahul Thorat, Sameer Salunkhe, Bikram Sahoo, Pratik Chandrani, Hitesh Kore, Bhabani Mohanty, Vikram Chaudhari, Anuradha Choughule, Dhananjay Kawle, Pradip Chaudhari, Arvind Ingle, Shripad Banavali, Poonam Gera, Mukta R Ramadwar, Kumar Prabhash, Savio George Barreto, Shilpee Dutt, Amit Dutt
The uncommonness of gallbladder cancer in the developed world has contributed to the generally poor understanding of the disease. Our integrated analysis of whole exome sequencing, copy number alterations, immunohistochemical, and phospho-proteome array profiling indicates ERBB2 alterations in 40% early-stage rare gallbladder tumors, among an ethnically distinct population not studied before, that occurs through overexpression in 24% (n=25) and recurrent mutations in 14% tumors (n=44); along with co-occurring KRAS mutation in 7% tumors (n=44)...
October 10, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30277653/pattern-of-distant-metastases-in-primary-extrahepatic-bile-duct-cancer-a-seer-based-study
#2
Xuan Wang, Guang-Yang Yu, Mo Chen, Ran Wei, Jinhong Chen, Zheng Wang
Extrahepatic bile duct cancer (EBDC) is a combined type of malignancy mainly consisting of extrahepatic cholangiocarcinoma and gallbladder cancer. Clinically, it is featured with latent symptoms and early metastasis, leading to a poor prognosis. Therefore, this cohort study aimed to depict the possible metastatic patterns of EBDC of diverse sub-types and evaluate the prognostic significance of diverse metastatic destinations with data from the clinical database. Relevant data of total 4061 confirmed EBDC patients diagnosed between 2010 and 2013 from the Surveillance, Epidemiology and End Results (SEER) database was obtained...
September 12, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30176555/primary-squamous-cell-carcinoma-of-the-gallbladder-report-of-a-rare-neoplasm-from-the-eastern-province-of-saudi-arabia
#3
Mohammed Y Aldossary, Amal A Alayed, Samir Amr, Mohammed S Alqahtani
INTRODUCTION: Primary squamous cell carcinoma of the gallbladder is extremely rare, and accounts for about 3% of all malignant gallbladder neoplasms. PRESENTATION OF CASE: We report the case of a 58-year-old woman who presented with acute onset epigastric pain radiating to the back. The initial diagnosis, based on radiological images, was an incidental gallbladder mass with multiple gallstones. A staging laparoscopy was performed, followed by exploratory laparotomy with radical cholecystectomy...
August 30, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/30159303/mirizzi-syndrome-diagnosis-and-management-of-a-challenging-biliary-disease
#4
Gennaro Clemente, Andrea Tringali, Agostino M De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante
Background: Mirizzi syndrome is a condition difficult to diagnose and treat, representing a particular "challenge" for the biliary surgeon. The disease can mimic cancer of the gallbladder, causing considerable diagnostic difficulties. Furthermore, it increases the risk of intraoperative biliary injury during cholecystectomy. The aim of this study is to point out some particular aspects of diagnosis and treatment of this condition. Methods: The clinical records of patients with Mirizzi syndrome, treated in the last five years, were reviewed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30089420/are-incidentally-detected-gall-bladder-cancers-really-incidental-a-report-of-two-cases-from-a-developing-nation
#5
Ashish Gupta, Amit Gupta, Sweety Gupta, Udit Chauhan, Lokavarapu Manoj Joshua
Gallbladder cancer (GBC) is a rare gastrointestinal tumour. It occurs in women with pre-existing cholelithiasis. These tumours pose therapeutic as well as diagnostic challenges to treating clinicians. Early suspicion and optimal surgery for suspected GBC results in the best outcome. We describe two cases of metastatic GBC initially treated by simple cholecystectomy for gallstone despite disease pointers towards a malignant pathology. Subsequent presentation was with histopathologically proven metastatic GBC...
August 8, 2018: Tropical Doctor
https://www.readbyqxmd.com/read/30082558/radiological-diagnosis-alone-risks-overtreatment-of-benign-disease-in-suspected-gallbladder-cancer-a-word-of-caution-in-an-era-of-radical-surgery
#6
Shraddha Patkar, Rajesh S Shinde, Sagar R Kurunkar, Devayani Niyogi, Nitin S Shetty, Mukta Ramadwar, Mahesh Goel
BACKGROUND: Incidental gallbladder cancer (iGBC) is on the rise world over. This may be a good scenario as we get to treat GBC in early stages. However, there is a practice of diagnosing patients based on clinicoradiological findings alone and subjecting them to a radical surgical procedure. This approach over-treats patient and has important implications for resource utilization. METHODS: We performed a retrospective analysis of 284 consecutive patients undergoing upfront surgery for suspected GBC from January 2010 to December 2016...
October 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/30025250/the-population-based-incidence-and-mortality-of-biliary-tract-cancer-in-sweden
#7
Carl Kilander, Jesper Lagergren, Rickard Ljung, Omid Sadr-Azodi
BACKGROUND: The incidence trends of biliary tract cancer need to be established. This study investigated the incidence and mortality of biliary tract cancer in Sweden in 1970-2010. METHODS: Sex-specific biliary tract cancer incidence and mortality rates were evaluated using data from the Swedish Cancer Register, Patient Register and Causes of Death Register. Case registration was separate for each register. Gallbladder cancer and cancers of the extra-hepatic bile ducts were analyzed separately...
October 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/30003469/rare-case-of-a-gallbladder-neuroendocrine-carcinoma
#8
Masakuni Fujii, Hiroaki Saito, Junji Shiode
There are no neuroectodermal cells in the gallbladder mucosa. Therefore, gallbladder neuroendocrine carcinoma (NEC) is extremely rare and has a poor prognosis. We report a case of a Japanese man in his 60s with this disease. The patient visited a family doctor for epigastralgia. Blood tests showed no abnormalities, including tumor markers, such as CEA and CA19-9. Abdominal ultrasonography (US) showed a low-echoic mass, 39 × 30 mm, with clear boundaries to the liver from the fundus of the gallbladder. Contrast-enhanced computed tomography showed that the tumor was enhanced early and washed out...
July 12, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29995783/long-term-outcomes-and-prognostic-markers-in-gallbladder-cancer
#9
Xiwei Cui, Sha Zhu, Zhihang Tao, Xinghao Deng, Yexiao Wang, Yuanjing Gao, Yue Liao, Weijun Ma, Yiwen Zhang, Xuelei Ma
Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients with gallbladder cancer patients.We performed a retrospective study of 159 patients received different therapies in West China Hospital from 2009 to 2014. The preoperative biomarker data, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lactate dehydrogenase, and alkaline phosphatase, as well as other clinical information, were obtained from electronic record...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29914418/gallbladder-cancer-review-of-a-rare-orphan-gastrointestinal-cancer-with-a-focus-on-populations-of-new-mexico
#10
REVIEW
Jacklyn M Nemunaitis, Ursa Brown-Glabeman, Heloisa Soares, Jessica Belmonte, Ben Liem, Itzhak Nir, Victor Phuoc, Rama R Gullapalli
Gallbladder cancer is a rare malignancy of the biliary tract with a poor prognosis, frequently presenting at an advanced stage. While rare in the United States overall, gallbladder cancer has an elevated incidence in geographically distinct locations of the globe including Chile, North India, Korea, Japan and the state of New Mexico in the United States. People with Native American ancestry have a much elevated incidence of gallbladder cancer compared to Hispanic and non-Hispanic white populations of New Mexico...
June 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29891423/high-rate-of-positive-lymph-nodes-in-t1a-gallbladder-cancer-does-not-translate-to-decreased-survival-a-population-based-propensity-score-adjusted-analysis
#11
Nastassja Köhn, Johannes Maubach, Rene Warschkow, Catherine Tsai, Daniel P Nussbaum, Daniel Candinas, Beat Gloor, Bruno M Schmied, Dan G Blazer, Mathias Worni
BACKGROUND: Current consensus guidelines suggest that gallbladder cancer (GBC) patients with resected T1a disease can be observed while patients with T1b or greater lesions should undergo lymphadenectomy (LNE). The primary aim of this study was to critically explore the impact of LNE in early-stage GBC on overall survival (OS) on a population-based level. METHOD: The 2004-2014 National Cancer Database was reviewed to identify non-metastatic GBC patients with T1a, T1b, or T2 disease and grouped whether a dedicated LNE was performed...
June 8, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29843968/reasonable-cholecystectomy-of-gallbladder-polyp-10-years-of-experience
#12
Sung Ryol Lee, Hyung Ook Kim, Jun Ho Shin
BACKGROUND AND OBJECTIVE: Although the incidence of carcinoma is not high in gallbladder polyps, it is essential to diagnose gallbladder cancer at an early stage to achieve a good therapeutic outcome. Therefore, the aim of this study was to define the characteristics of gallbladder polyps to establish sound criteria for surgical indications. METHODS: In the current study, data from 516 patients with gallbladder polyps who underwent cholecystectomy were reviewed to correlate clinical features with histopathologic findings and identify risk factors with receiver-operating characteristic curves (ROCs)...
May 26, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29794366/early-recurrence-after-laparoscopic-radical-cholecystectomy-in-a-patient-with-gallbladder-cancer
#13
Kunal Parasar, Sundeep Singh Saluja, Vaibhav Kumar Varshney, B Deepak, Pramod Kumar Mishra
Laparoscopic radical cholecystectomy for gallbladder cancer (GBC) has been performed at various oncology centres reporting its technical feasibility. Considering GBC an aggressive malignancy, laparoscopic radical cholecystectomy should be dealt with caution. We recently encountered a case of carcinoma gallbladder who underwent laparoscopic radical cholecystectomy elsewhere and presented with early recurrence. The patient's records were evaluated and he underwent re-resection. Hereby, we discuss the factors that could lead to early recurrence after laparoscopic radical cholecystectomy and measures that can be taken to prevent it...
May 24, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29736837/establishment-of-a-gallbladder-cancer-specific-survival-model-to-predict-prognosis-in-non-metastatic-gallbladder-cancer-patients-after-surgical-resection
#14
Woods Zhang, H J Hong, Yan-Ling Chen
BACKGROUND: Gallbladder cancer is an invasive cancer with a discouraging prognosis, and early detection and active intervention are of great value. AIMS: To establish a more accurate and effective survival model to predict the prognosis of patients with non-metastatic gallbladder after surgical resection. METHODS: A retrospective analysis was conducted in non-metastatic gallbladder cancer patients who were registered in the surveillance, epidemiology and end results database from 2010 to 2014...
May 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29693707/c%C3%A2-jun-suppresses-the-expression-of-wnt-inhibitory-factor-1-through-transcriptional-regulation-and-interaction-with-dna-methyltransferase-1-in-gallbladder-cancer
#15
Bin Lin, Haijie Hong, Xiaojie Jiang, Chengzong Li, Siyuan Zhu, Nanhong Tang, Xiaoqian Wang, Feifei She, Yanling Chen
WNT inhibitory factor 1 (WIF‑1) is involved in the tumorigenicity and progression of several types of tumor, which has been attributed to aberrant hypermethylation of its promoter. However, the role of WIF‑1 in the pathogenesis of gallbladder cancer (GBC) remains to be fully elucidated, and the data available are insufficient to identify the upstream molecular mechanisms involved. In the present study, the methylation status of the WIF‑1 promoter was investigated using methylation‑specific polymerase chain reaction (PCR) and bisulfate sequencing PCR in GBC cells...
June 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29668579/gallbladder-cancer-with-tumor-thrombus-in-the-portal-vein-a-case-report
#16
Xiao-Zhen Zhang, Jian-Jun Tu, Wei Chen, Tao Ma, Xue-Li Bai, Ting-Bo Liang
RATIONALE: Gallbladder cancer (GBC) is a highly fatal malignancy. Due to its invasiveness and delayed diagnosis, many GBC patients are diagnosed with synchronous liver and hepatoduodenal ligament involvement. In our case, we report a gallbladder cancer with portal vein thrombus. PATIENT CONCERNS: A 60-year-old woman presented with persistent upper abdominal dull pain for 2 months. DIAGNOSES: Ultrasound examination showed gallbladder carcinoma invading liver segment IV, and a tumor thrombus in the left and right main portal trunk...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29664654/annual-trends-of-gastrointestinal-cancers-mortality-in-iran-during-1990-2015-nasbod-study
#17
Hamideh Salimzadeh, Farnaz Delavari, Catherine Sauvaget, Negar Rezaee, Alireza Delavari, Farzad Kompani, Nazila Rezaei, Ali Sheidaei, Mitra Modirian, Rosa Haghshenas, Maryam Chegini, Kimiya Gohari, Hossein Zokaiee, Farshad Farzadfar, Reza Malekzadeh
BACKGROUND: Gastrointestinal (GI) neoplasms are among the most common cancers in Iran. This study aimed to measure annual trends in mortality rates from GI cancers in Iran between 1990 and 2015. METHODS: This study was part of an ongoing study termed the 'National and Subnational Burden of Diseases' study in Iran. Data used in this study was obtained from the Iranian Death Registration System (1995 to 2010) and from 2 major cemeteries in Tehran (1995 to 2010) and Isfahan (2007 to 2010)...
February 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29650921/-a-case-of-laparoscopic-whole-layer-cholecystectomy-for-elevated-lesion-suspected-biliary-cancer
#18
Yosuke Ishihara, Kei Naito, Koji Miyagawa, Satoshi Kataoka, Nobuaki Fuji
A case of attempted laparoscopic cholecystectomy for elevated lesion which was clearly early biliary cancer. Laparoscopic cholecystectomy has become popular as a minimally invasive surgical method, and is the primary choice for benign diseases. However for cases of suspected biliary cancer, open cholecystectomy, rather than laparoscopic, is recommended according to medical guidelines. The reason for this is that in cases of damage to the gallbladder, bile spillage to the abdominal cavity may occur, leading to port site recurrence and peritoneal recurrence...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29618736/circulating-levels-of-inflammatory-proteins-and-survival-in-patients-with-gallbladder-cancer
#19
Zhiwei Liu, Troy J Kemp, Yu-Tang Gao, Amanda Corbel, Emma E McGee, Juan Carlos Roa, Bingsheng Wang, Juan Carlos Araya, Ming-Chang Shen, Asif Rashid, Ann W Hsing, Allan Hildesheim, Catterina Ferreccio, Ruth M Pfeiffer, Ligia A Pinto, Jill Koshiol
Although inflammation is central to gallbladder cancer (GBC) development and proliferation, no study has systematically investigated circulating inflammatory proteins and patient survival. We aimed to examine whether the circulating levels of inflammatory proteins is associated with all-cause mortality among such patients. We recruited 134 patients with newly diagnosed with GBC from 1997 to 2001 in a population-based study in Shanghai and an independent set of 35 patients from 2012 to 2013 in Chile. Cox proportional hazards regression models adjusted for covariates were used to evaluate the hazard ratios (HRs) for death by serum levels of 49 inflammatory proteins (quartiles)...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29602013/dna-methylation-as-an-epigenetic-regulator-of-gallbladder-cancer-an-overview
#20
REVIEW
Jibran Sualeh Muhammad, Muhammad Rizwan Khan, Kulsoom Ghias
Gallbladder cancer (GBC) is a lethal health issue affecting mostly the women in their middle-age. High incidence of GBC has been reported across the world specifically in Asian countries, India and Pakistan. The exact etiology remains unknown, although several risk factors and genetic aberrations involving mutations or epigenetic changes may be involved in gallbladder carcinogenesis. This article presents a review of the published literature mainly from the year 2003 onwards. The topic of main concerns was epigenetic regulation of GBC...
May 2018: International Journal of Surgery
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