Tareq Saleh, Sofian Al Shboul, Heyam Awad, Mohammed El-Sadoni, Ahmad Alhesa, Elham Alsharaiah, Nisreen Abu Shahin, Moureq R Alotaibi, AbdelKader Battah, Bilal Azab
The use of chemotherapy has improved the overall treatment of breast cancer, which is frequently administered in the form of neoadjuvant chemotherapy (NAC). Apoptosis is an established cell stress response to NAC in preclinical models; however, there is limited understanding of its role in clinical cancer, specifically, its contribution to favorable pathologic responses in breast cancer therapy. Here, we aimed to characterize the change in protein expression of 3 apoptosis-associated biomarkers, namely, BCL-XL, MCL-1, and BAX in breast cancer in response to NAC...
March 1, 2024: Applied Immunohistochemistry & Molecular Morphology: AIMM