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breast cytology

Julien J Shine, Elie Boghossian, Gabriel Beauchemin, Vasilios W Papanastasiou, Daniel E Borsuk
INTRODUCTION: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare and recently described type of peripheral T-cell lymphoma. Fewer than 550 cases have been reported worldwide. Although BIA-ALCL is usually indolent, early diagnosis and treatment have been shown to improve outcome. CASE DESCRIPTION: This case report describes the management of a 50-year-old healthy Caucasian woman presenting with rapid painful enlargement of the left breast...
August 9, 2018: Aesthetic Plastic Surgery
Indranil Chakrabarti
The triple test lies at the heart of preoperative diagnosis of breast lesions. Raised awareness and self-assessment have significantly increased the rate of detection of breast pathologies. The managing clinicians usually decide the imaging and pathological modalities to the best interest of the patients. Core needle biopsy (CNB), cell-block studies, and fine needle aspiration cytology (FNAC) coupled with rapid on-site evaluation (ROSE) have significantly increased the accuracy of preoperative diagnosis. Immunocytochemistry, immunohistochemistry on cell blocks, and other ancillary studies give confidence to the clinicians to decide the best treatment strategies...
July 2018: Journal of Cytology
Meherbano M Kamal, Hemant R Kulkarni, Manjiri M Makde, Radha Munje
Objective: To assess the performance of fine needle aspiration cytology (FNAC) in the diagnosis of tuberculosis mastitis. Materials and Methods: Diagnostic test performance evaluation using two methods-as compared to an alloyed gold standard as well as in the absence of a gold standard. Alloyed gold standard combined the results of acid fast bacilli in cytology smears, histopathological confirmation, and response to treatment. Bayesian estimation of test parameters was done in the absence of the gold standard...
July 2018: Journal of Cytology
Anamika Sinha, Satyajit S Gill
Context: Fine-needle aspiration cytology (FNAC) is a proven diagnostic technique for establishing the benign or malignant character of breast lesions. Several cytological grading systems have been proposed for grading of carcinoma breast, with results similar to histologic grades. Aims: This study sought to evaluate the prognostic value of FNAC in invasive ductal carcinoma of breast by correlating it with histological grade. Settings and Design: Tertiary care hospital, retrospective analytical study...
July 2018: Journal of Cytology
Ronald Enrique Delgado-Bocanegra, Eduardo Camargo Millen, Cristina Moreira do Nascimento, Karine de Aguiar Bruno
OBJECTIVES: To compare imprint cytology and paraffin section histology for sentinel lymph node detection in women with breast cancer treated with neoadjuvant chemotherapy. METHOD: A cross-sectional study and report of the sentinel lymph node statuses of 64 patients with breast cancer who underwent intraoperative imprint cytology and neoadjuvant chemotherapy in a referral cancer institute in Rio de Janeiro, Brazil, between 2014 and 2016. RESULTS: The mean age was 51 years...
August 2, 2018: Clinics
Siyu Wu, Yujie Wang, Na Zhang, Jianwei Li, Xiaoli Xu, Juping Shen, Guangyu Liu
BACKGROUND: For breast cancer patients, a false-negative rate lower than 10% can be achieved if targeted axillary dissection (TAD) is performed, which includes the excision of both biopsy-proven positive lymph nodes (BxLNs) and sentinel lymph nodes (SLNs). However, little evidence exists on the accuracy of intraoperative touch imprint cytology (ITPC) applied in TAD after neoadjuvant chemotherapy (NAC) for breast cancer patients with initial axillary metastasis. This study aimed to investigate the accuracy of ITPC in TAD after NAC...
August 6, 2018: Annals of Surgical Oncology
Neelam Sood, Navmeet Soin, Ruchika Gupta, Sanjay Gupta
A 28-year female presented with a lump in the left breast for three months. She was non- lactating and had no family history of breast malignancy. Local examination showed a 3 cm firm mass in the upper inner quadrant of left breast. The mass was mobile and not fixed to the overlying skin or underlying muscle. This article is protected by copyright. All rights reserved.
July 25, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Masumi Osugi, Kosei Kinoshita, Atsuro Sugita, Katsumi Kito, Toshiharu Maeda
BACKGROUND: We performed p63 immunostaining to detect myoepithelial cells on BD SurePath liquid-based cytology (LBC) slides and examined whether this improved the diagnostic accuracy in breast fine-needle aspiration cytology (FNAC). METHODS: We examined the diagnostic accuracy using the LBC-p63 immunostaining slides of 298 lesions obtained from July 2010 to August 2016. RESULTS: We defined the cutoff values for malignancy as follows: (1) the percentage of p63+ cluster was <30%, (2) the percentage of p63+ single cells in cell clusters was <3%, (3) the number of p63+ single cells in the background was <20 when the total number of the cell clusters was <100, or the number was <120 when the total number was ≥100...
July 25, 2018: Diagnostic Cytopathology
Iosief Abraha, Diego Serraino, Alessandro Montedori, Mario Fusco, Gianni Giovannini, Paola Casucci, Francesco Cozzolino, Massimiliano Orso, Annalisa Granata, Marcello De Giorgi, Paolo Collarile, Rita Chiari, Jennifer Foglietta, Maria Francesca Vitale, Fabrizio Stracci, Walter Orlandi, Ettore Bidoli
OBJECTIVES: To assess the accuracy of International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes in identifying patients diagnosed with incident carcinoma in situ and invasive breast cancer in three Italian administrative databases. DESIGN: A diagnostic accuracy study comparing ICD-9-CM codes for carcinoma in situ (233.0) and for invasive breast cancer (174.x) with medical chart (as a reference standard). Case definition: (1) presence of a primary nodular lesion in the breast and (2) cytological or histological documentation of cancer from a primary or metastatic site...
July 23, 2018: BMJ Open
Lindsay Volk, Hirohisa Ikegami, Leonard Y Lee, Anthony Lemaire
BACKGROUND: Pericardial effusion (PE) is a common finding in patients who have chronic cardiac failure, who had undergone cardiac surgery, or who have certain other benign and malignant diseases. Pericardial drainage procedures are often requested for both diagnostic and therapeutic purposes. The perceived benefit is that it allows for diagnosis of malignancy or infection for patients with PEs of unclear etiology. The purpose of the study is to determine the diagnostic yield of surgical drainage procedures...
July 18, 2018: Journal of Cardiothoracic Surgery
Rosa Falcone, Valeria Ramundo, Livia Lamartina, Valeria Ascoli, Daniela Bosco, Cira Di Gioia, Teresa Montesano, Marco Biffoni, Marco Bononi, Laura Giacomelli, Antonio Minni, Maria Segni, Marianna Maranghi, Vito Cantisani, Cosimo Durante, Giorgio Grani
Incidental sonographic discovery of thyroid nodules is an increasingly common event. The vast majority is benign, and those that are malignant, are generally associated with an indolent course and low mortality. Sonographic scoring systems have been developed to help clinicians identify nodules that warrant prompt fine-needle aspiration cytology (FNAC), but they are based largely on experience with papillary thyroid cancers. We analyzed the performance of four scoring systems widely used for this purpose (American Thyroid Association Guidelines, American Association of Clinical Endocrinologists/American College of Endocrinology/Associazione Medici Endocrinologi Guidelines, European Thyroid Imaging Reporting and Data System, and Korean Thyroid Imaging Reporting and Data System) in patients whose nodules proved to be metastases from other solid cancers...
August 1, 2018: Journal of the Endocrine Society
Adheesh Bhandari, Erjie Xia, Yinghao Wang, Namita Sindan, Ranjan Kc, Yaoyao Guan, Yueh-Lung Lin, Xiaoshang Wang, Xiaohua Zhang, Ouchen Wang
Comparing diagnostic accuracy study between ultrasonography (US) guided fine-needle aspiration biopsy (FNAB) and core-needle biopsy (CNB) of the Sentinel lymph nodes (SLNs) in newly diagnosed invasive breast cancer patients. We selected 289 newly diagnosed invasive breast cancer patients from June 2015 to July 2017. Ultrasound (US) guided fine-needle aspiration cytology (FNA) and core-needle biopsy (CNB) was performed to identify patients with suspicious sentinel lymph node (SLN). Patients with a cortical thickness > 2 mm or atypical morphological characteristics were recommended FNA and CNB...
2018: American Journal of Translational Research
Horiana B Grosu, Farah Kazzaz, Erik Vakil, Sofia Molina, David Ost
BACKGROUND: Thoracentesis with cytological examination of pleural fluid is the initial test of choice for evaluation of pleural effusions in patients with suspected malignant pleural effusion (MPE). There is limited data on the sensitivity of thoracentesis stratified by tumor type. A better understanding of stratified sensitivities is of clinical interest, and may guide early and appropriate referral for pleural biopsy. OBJECTIVE: The primary objective was sensitivity of thoracentesis with pleural fluid cytology stratified by tumor type...
July 17, 2018: Respiration; International Review of Thoracic Diseases
Chethan K Belludi, Edward T Qian, James J Tolle, Ryan M Brown, Mary Ann Thompson, Ridas Juskevicius
Anaplastic large cell lymphoma (ALCL) is a lymphoma of T-cell origin, characterized by the presence of large lymphoid cells with abundant cytoplasm and pleomorphic, often horseshoe-shaped nuclei (hallmark cells), as well as strong and uniform expression of cluster of differentiation (CD)30. Two distinct clinicopathologic categories of ALCL include primary cutaneous ALCL and systemic ALCL. Systemic ALCL is further classified into anaplastic lymphoma kinase (ALK)-positive, ALK-negative, and breast implant-associated ALCL...
July 17, 2018: Laboratory Medicine
Zhenyu Pan, Guozi Yang, Hua He, Tingting Yuan, Yongxiang Wang, Yu Li, Weiyan Shi, Pengxiang Gao, Lihua Dong, Gang Zhao
In this study, we examined the characteristics and aimed to increase the knowledge of clinical features of leptomeningeal metastasis (LM). The clinical data, including initial diagnosis and treatment of primary tumor, clinical manifestations, neuroimaging findings, cerebrospinal fluid (CSF) examination, were analyzed. For the patients with adenocarcinoma/breast cancer, the incidence of cranial lesions and cranial nerve paralysis was obviously higher than patients with small cell lung cancer. Whereas, the incidence of involvement of intravertebral canal was obviously lower than that of small cell lung cancer...
July 11, 2018: Scientific Reports
Carlos Manuel Ortiz-Mendoza, Norma Alicia Acosta Sánchez, Arturo Catarino Dircio
There are rare benign diseases that can mimic malignant breast neoplasms in the clinical exam and in mammography. We evaluated the contribution of an accessible procedure to most clinicians, the fine-needle aspiration cytology, to identify a rare mimicker of malignant breast neoplasms. A type 2 diabetic 85-year-old female presented with a 6-month history of a left breast lump. The physical exam and mammography were compatible with breast cancer. Nevertheless, after fine-needle aspiration cytology, the diagnosis was plasma cell mastitis...
July 9, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Xiaoju Li, Yuan Gao, Jialin Li, Kuo Zhang, Jun Han, Weina Li, Qiang Hao, Wangqian Zhang, Shuning Wang, Cheng Zeng, Wei Zhang, Yingqi Zhang, Meng Li, Cun Zhang
Forkhead box P3 (FOXP3), an X-linked tumor suppressor gene, plays an important role in breast cancer. However, the biological functions of FOXP3 in breast cancer angiogenesis remain unclear. Here we found that the clinical expression of nuclear FOXP3 was inversely correlated with breast cancer angiogenesis. Moreover, the animal study demonstrated that FOXP3 significantly reduced the microvascular density of MDA-MB-231 tumors transplanted in mice. The cytological experiments showed that the supernatant from FOXP3-overexpressing cells exhibited a diminished ability to stimulate tube formation and sprouting in HUVECs in vitro...
July 3, 2018: Cell Death & Disease
Oukseub Lee, Richard E Heinz, David Ivancic, Miguel Muzzio, Robert T Chatterton, Carola M Zalles, Kara Kenney, Belinda Phan, Dachao Liu, Denise M Scholtens, Mary Jo Fackler, Vered Stearns, Saraswati Sukumar, Seema A Khan
Sex steroid hormones contribute to breast cancer development, but data on concentrations of these within breast tissue are limited. We performed simultaneous multi-parameter measurement of breast sex steroids, breast epithelial cytology, and DNA methylation in 119 healthy women (54 pre- and 65 postmenopausal) without a history of breast cancer. Random fine needle aspiration (rFNA) of the breast was performed simultaneously with blood collection. Breast samples were analyzed by liquid chromatography-tandem mass spectrometry for estrone, estradiol, progesterone, androstenedione, and testosterone...
June 28, 2018: Cancer Prevention Research
Maria P Foschini, Vincenzo Eusebi
Microglandular adenosis of the breast (MA), a benign glandular proliferation, was originally described about 35years ago. The lesion, is constituted by small glands all of the same size. Glands are lined by one layer of cuboidal epithelial cells encircled by basal lamina without any evidence of interposed myoepithelial elements. Cells are positive for low weight keratins and S-100 protein and negative for ER, PR and HER 2. Since then, in the years, several malignant lesions all showing microglandular architecture have been regarded either as a precursor or an equivalent manifestation of MA...
June 24, 2018: Human Pathology
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