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breast cytology

Kusum Kapila, Preetha Alath, Govind H Hebbar, Mohammed Jaragh, Sara S George, Ayesha AlJassar
OBJECTIVE: Ultrasound-guided fine-needle aspiration cytology (USG-FNAC) is used for the detection of axillary lymph node (ALN) metastasis in patients with breast carcinoma (BC). US findings have a good diagnostic accuracy with high sensitivity and specificity. The aim of this study is to correlate the detection of ALN metastases on US with FNAC in BC patients. STUDY DESIGN: In 75 BC patients, over a period of 9 months (January to September 2017), the size, cortical thickness (CT), presence or absence of hilar fat, and length/width ratio of ALN on US were reviewed and correlated with FNAC findings...
December 5, 2018: Acta Cytologica
Ethar Al-Husseinawi, Soheila Hamidpour, Evanthia Omoscharka
Mammary analogue secretory carcinoma (MASC) of the salivary glands morphologic and molecular similarities to secretory carcinoma of the breast(sc). (1) Here, we report a 46 year old female who presented with a right submandibular gland mass. Fine needle aspiration differential diagnosis included oncocytosis, oncocytoma, acinic cell carcinoma and MASC.We also review the current literature regarding clinical presentation, and diagnostic workup of this entity. This article is protected by copyright. All rights reserved...
December 1, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Kaitlin E Sundling, Daniel F I Kurtycz
There has been increasing pressure for systemization in cytopathology. Lack of uniformity in categorization, variation in opinion based regional practice, and technologic advancement have created an environment disposed toward creation of more consistent evidence-based approaches to diagnostic problems. This review provides an overview of the major standardized terminology systems in cytology, with historical perspectives and commentary on current uses of these systems. These systems now include gynecologic, thyroid, pancreaticobiliary, urinary, salivary gland, and breast cytology...
November 29, 2018: Diagnostic Cytopathology
Kalpalata Tripathy, Aparajita Mishra, Ajit K Singh, Pragnya L Panda, Arup Mahapatra, Anusaya Lenka
Context: Efficacy of immunocytochemistry (ICC) in determining molecular biomarkers like estrogen receptor (ER), progesterone receptors (PRs), and human epidermal growth factor receptor-2 (HER2). Aims: To evaluate biomarkers using ICC in breast cancer as per American Society of Clinical Oncology/College of American Pathology (ASCO/CAP) guidelines. Settings and Design: The study was conducted over a period of 2 years from September 2012 to August 2014 and is the first such study in eastern India...
October 2018: Journal of Cytology
Pooja K Suresh, Jyoti Ramanath Kini, Sridevi H Basavaiah, Hema Kini, Urmila N Khadilkar, Shrijeet Chakraborti
Introduction: Neoplastic involvement of cerebrospinal fluid (CSF) secondary to known or unknown primaries elsewhere is a poor prognostic factor and is equivalent to stage IV disease. Aim: The aim of the study is to analyse the cytological features of neoplastic meningitis in a tertiary care center. Materials and Methods: A retrospective study of 400 consecutive CSF samples was done in the cytology laboratory of our hospital. The fluid obtained by spinal tap was sent for microbiological, biochemical and cytological evaluation...
October 2018: Journal of Cytology
Barkha Gupta, Varuna Mallya, Shyama Jain, P N Agarwal
Objectives: Cutaneous metastasis (CM) though rare, indicates a terminal event in any malignancy and has a grave outcome. The present study reiterates the role of fine needle aspiration cytology (FNAC) in the diagnosis of metastatic cutaneous nodules. Materials and Methods: From 2015 to 2017, the department received 22,000 cases for FNAC. Among these cases, aspirations from the skin and subcutaneous region were performed on 6,083 cases. After excluding primary tumors of skin/subcutis, 25 cases on cytology were suggestive of metastasis...
October 2018: Journal of Cytology
Pampa Ch Toi, Siddaraju Neelaiah, Kadambari Dharanipragada, Kumar Surendra
Background: There has been a limited literature with regards to comparison between the pre-operative hormonal/Her-2 neu assessment by immunostaining on fine-needle aspiration (FNA) versus core needle biopsies (CNBs) and their correlation with grading of breast carcinoma. Materials and Methods: Two hundred fifty FNAs and 201 CNBs from 252 patients with breast carcinoma were subjected immunocytochemical/histochemical (ICC/IHC) staining along with the grading by the Robinson cytologic and modified Scarff-Bloom-Richardson scoring systems, respectively...
October 2018: Journal of Cytology
Betty Abraham, T R Sarojini
Context: Cytological assessment using various morphological parameters helps segregate breast lesions in fine-needle aspiration cytology (FNAC) into different categories. The prognosis and the line of management of each category differ accordingly. Aims: This study aims at assessing the validity of Modified Masood's Scoring Index (MMSI) by the evaluation of cytomorphological features of various breast lesions compared with histopathological findings. Settings and Design: This is a cross-sectional study done in 65 female patients with palpable or nonpalpable breast lesions, undergoing FNAC and biopsy over a period of 18 months from December 1, 2012, to May 31, 2014...
October 2018: Journal of Cytology
Sajjan M Netra, B R Vani, V Srinivasa Murthy
Introduction: Medullary breast carcinoma (MBC) is one of the rare variants of breast carcinoma, accounting for less than 5% of invasive breast carcinoma. MBCs relatively appear a decade earlier when compared to invasive ductal carcinoma (IDC NOS), which is more prevalent in the elderly age. Subjects and Methods: A retrospective study was conducted in the Department of Pathology from 2009 to 2016. Fine needle aspiration cytology slides of MBCs and IDCs were retrieved, studied microscopically, and reviewed to compare the cytological features...
October 2018: Journal of Cytology
Carla Carrilho, Mamudo Ismail, Cesaltina Lorenzoni, Fabíola Fernandes, Matos Alberto, Kevan Akrami, Carlos Funzamo, Nuno Lunet, Fernando Schmitt
BACKGROUND: Fine needle aspiration cytology (FNAC) is an important diagnostic tool in a range of medical settings. It is fast, quick and a highly accurate diagnostic method and can be used, in settings with minimal laboratory infrastructures. METHODS: In this report, we describe the experience in the use of FNAC since it is introduction in 1996 in the Anatomical Pathology Service of the Maputo Central Hospital (MCH), along with more detailed data referring to 2009-2010...
November 26, 2018: Diagnostic Cytopathology
Xin He, Yihong Wang, Gahie Nam, Ana P Lourenco, Latha Pisharodi
BACKGROUND: Fine needle aspiration cytology (FNA) is a simple, safe, cost effective, and accurate method for diagnosis of cystic lesions of the breast. Our study aims to correlate FNA cytology of cystic lesions of the breast with the histologic diagnosis. METHODS: During a period of 10 years (2007-2017), 314 cases of breast cystic lesions were retrieved from a total 1073 cases of breast FNAs. Of these, 78 cases from 77 patients (mean age = 54.6, female: male = 76:1) with simultaneous FNA and core needle biopsy (CNB) and/or excision specimen were reviewed...
November 23, 2018: Diagnostic Cytopathology
Mª Jesús Fernández Aceñero, Ana Caso Viesca, Cristina Díaz Del Arco
INTRODUCTION: In the 19th century Virchow described that metastasis to left supraclavicular lymph nodes (SLN) could originate in neoplasms located under the diaphragm. In the same way, right SLN metastasis are usually thought to arise from thoracic neoplasms. Our aims are to review our experience with metastatic SLN diagnosed by fine-needle aspiration cytology (FNAC) and to discuss the location of the primary in these cases. METHODS: We have reviewed all lymph node FNACs diagnosed in a single tertiary hospital between 2010 and 2017 and we have included all cases of metastatic SLN...
November 23, 2018: Diagnostic Cytopathology
Sigei Asha, Elshenawy Yasmin, Janet F Stastny
Skeletal muscle metastasis from breast carcinoma is a relatively rare clinical entity. We report two cases of breast cancer metastatic to the skeletal muscle, diagnosed by ultrasound guided fine needle aspiration (US-FNA) biopsy done by interventional cytopathologists at an outpatient cytopathology center. Our two patients presented with lower anterior neck firmness and chest wall mass, respectively. Ultrasound evaluation of our first case demonstrated hypo-echoic thickened anterior strap muscles while in the second case there was significant distortion of the anatomy from previous surgeries...
November 23, 2018: Diagnostic Cytopathology
Arghya Bandyopadhyay, Kaushik Sen, Nirmalya Chakrabarti, Shantanu Datta
Galactocele, although a common cytological diagnosis in females, is not previously reported as a cause of breast enlargement in adult males. Hyperprolactinemia is the principal cause of galactocele in male breast. Besides drug induced hyperprolactinemia, other anatomical lesions of hypothalamo-pituitary region and different medical conditions like cirrhosis and chronic kidney disease are to be considered along with a full evaluation of features revealing hypogonadism in case of galactocele. Aspirated milk from the male breast is the primary clue for this detailed investigation process...
November 21, 2018: Diagnostic Cytopathology
Aruna Nambirajan, Moanaro Longchar, Karan Madan, Saumya Ranjan Mallick, Aanchal Kakkar, Sandeep Mathur, Deepali Jain
BACKGROUND: Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) is the primary modality for mediastinal lymph node staging in lung carcinoma. We aimed to evaluate its utility in extra-pulmonary malignancies (EPM). METHODS: Database search of EBUS-TBNA aspirations (2013-2017) done in patients with known/suspected EPMs and mediastinal lymphadenopathy/masses was performed. All archived cytology/histology material was reviewed and categorized as positive, negative and unsatisfactory...
November 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Lindsay Angus, John W M Martens, Martin J van den Bent, Peter A E Sillevis Smitt, Stefan Sleijfer, Agnes Jager
Leptomeningeal metastases (LM) in breast cancer patients are rare but often accompanied by devastating neurological symptoms and carries a very poor prognosis, even if treated. To date, two diagnostic methods are clinically used to diagnose LM: gadolinium MRI of the brain and/or spinal cord and cytological examination of cerebrospinal fluid (CSF). Both techniques are however hampered by limited sensitivities, often leading to a long diagnostic process requiring repeated lumbar punctures and MRI examinations...
November 10, 2018: Neuro-oncology
Shahin Sayed, Andrew Field, Jamilla Rajab, Anderson Mutuiri, Jessie Githanga, Mary Mungania, Nancy Okinda, Zahir Moloo, Abubakar Abdillah, Brian Ayara, Erick Chesori, Julia Muthua, Leah Obosy, Thaddeus Massawa, Okoth Obiero, Elizabeth Kagotho, Peter K Shikuku, Andrew K Gachii, Eunida Migide, Donstefano Muninzwa, Sanford M Dawsey, Lucy Muchiri
PURPOSE: Fine-needle aspiration biopsy (FNAB) cytology is a simple, inexpensive, and accurate diagnostic test for benign, infectious, and malignant lesions of the breast, thyroid, lymph nodes, and other organs. Similarly, bone marrow aspiration and trephine (BMAT) biopsy procedures are relatively simple and inexpensive techniques that are important for diagnosing and monitoring many hematologic diseases including leukemias and lymphomas. However, the scarcity of pathologists in Kenya limits patient access to these simple diagnostic tests...
November 2018: Journal of Global Oncology
Perikala Vijayananda Kumar, Maral Mokhtari
OBJECTIVE: Phyllodes tumors are fibroepithelial breast lesions with many cytological and histopathological similarities to fibroadenomas. The aim of this study was to investigate cytological findings in benign phyllodes tumors. STUDY DESIGN: Seventy-six histologically proven cases of benign phyllodes tumors were selected from 1982 to 2017. Cytological criteria, including cellularity, the number and shape of epithelial clusters, the shape and number of stromal fragments, and the presence of atypia, were evaluated...
October 26, 2018: Acta Cytologica
Konstantinos Dinas, Georgios C Pratilas, Maria Nasioutziki, Eleftherios Vavoulidis, Vasileios Makris, Panagiotis D Loufopoulos, Matthias Kalder
BACKGROUND: Fine needle aspiration cytology (FNAC) has been and still is challenged about its role in the management of breast lesions. Guidelines today mandate that breast lesions should be managed with a triple assessment system consisting of clinical, radiological, and pathological evaluation. AIM: This article will try and clarify whether FNAC stands as a tool in this assessment. MATERIALS AND METHODS: PubMed was searched for articles concerning prospective, retrospective and review studies about clinical applications of FNAC...
September 1, 2018: Folia Medica
Neelam Sood
Nipple discharge (ND) either in the presence or in the absence of underlying mass is a very uncommon presentation in males and its bloody nature is still rarer. ND cytology in males has not been reported much in the literature. Spontaneous and expressed ND, however, can be very useful in establishing the diagnosis. Two males with bloody ND, one, without any palpable mass and another with underlying mass, were evaluated on ND cytology. The presence of loose papillaroid clusters and cell sheets with mild atypia was seen in ND smears itself in case 1...
October 24, 2018: Diagnostic Cytopathology
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