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https://www.readbyqxmd.com/read/28823105/understanding-peripartum-depression-through-neuroimaging-a-review-of-structural-and-functional-connectivity-and-molecular-imaging-research
#1
REVIEW
Christy Duan, Jessica Cosgrove, Kristina M Deligiannidis
PURPOSE OF REVIEW: Imaging research has sought to uncover brain structure, function, and metabolism in women with postpartum depression (PPD) as little is known about its underlying pathophysiology. This review discusses the imaging modalities used to date to evaluate postpartum depression and highlights recent findings. RECENT FINDINGS: Altered functional connectivity and activity changes in brain areas implicated in executive functioning and emotion and reward processing have been identified in PPD...
August 19, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28822877/assessment-of-tobacco-heating-product-thp1-0-part-8-study-to-determine-puffing-topography-mouth-level-exposure-and-consumption-among-japanese-users
#2
Jodie Gee, Krishna Prasad, Sandra Slayford, Adam Gray, Kathryn Nother, Anthony Cunningham, Eleni Mavropoulou, Christopher Proctor
A four-arm study was undertaken in Japan to determine the puffing topography, mouth level exposure and average daily consumption by consumers of the tobacco heating products (THPs): the non-mentholated THP1.0(T), the mentholated THP1.0(M) and a tobacco heating system (THS). The extent of lip blocking of air inlet holes while using THP1.0(T) was also assessed. Groups 1, 2, and 4 included smokers, and group 3 included regular THP users. Smokers of 7-8 mg ISO nicotine free dry particulate matter (NFDPM) non-mentholated cigarettes took on average larger mean puff volumes from THPs than from conventional cigarettes, but puff numbers and durations were similar...
August 16, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28822157/-the-analysis-of-multivariate-image-and-chemometrics-in-tlc-fingerprinting-of-artificial-cow-bezoar
#3
Ling-Wen Yao, Yan Shi, Dong-Mei Sun, Xian-Long Cheng, Feng Wei, Shuang-Cheng Ma
A method of thin-layer fingerprinting chromatogram of artificial cow-bezoar was established with the developing solvent consisting of cyclohexane, ethyl acetate, acetic acid and methanol (2∶7∶1∶2), and 10% sulfuric acid ethanol solution sprayed as colour-developing agent. After heated at 105 ℃, TLC was recorded as an image in ultraviolet light at 366 nm which was converted into grayscale. By the gray value extracted from the grayscale, the multivariate data obtained from TLC of samples could be analyzed by chemometric method...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821248/morphology-of-the-snake-spectacle-reflects-its-evolutionary-adaptation-and-development
#4
Mari-Ann Otkjaer Da Silva, Steffen Heegaard, Tobias Wang, Jacob Thorup Gade, Christian Damsgaard, Mads Frost Bertelsen
BACKGROUND: Covering the eye of all snakes is a transparent integumental structure known as the spectacle. In order to determine variations in spectacle thickness among species, the spectacles of 217 alcohol-preserved museum specimens of 44 species belonging to 14 different families underwent optical coherence tomography (OCT) to measure spectacular thickness. Multivariable analyses were made to determine whether family, activity period (diurnal/nocturnal) and habitat (arboreal/terrestrial/fossorial/aquatic) influenced spectacle thickness...
August 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28820901/using-local-ecological-knowledge-to-monitor-threatened-mekong-megafauna-in-lao-pdr
#5
Thomas N E Gray, Amphone Phommachak, Kongseng Vannachomchan, Francois Guegan
Pressures on freshwater biodiversity in Southeast Asia are accelerating yet the status and conservation needs of many of the region's threatened fish species are unclear. This impacts the ability to implement conservation activities and to understand the effects of infrastructure developments and other hydrological changes. We used Local Ecological Knowledge from fishing communities on the Mekong River in the Siphandone waterscape, Lao PDR to estimate mean and mode last capture dates of eight rare or culturally significant fish species in order to provide conservation monitoring baselines...
2017: PloS One
https://www.readbyqxmd.com/read/28820788/community-health-workers-and-the-management-of-noncommunicable-diseases-among-rural-health-clinics-in-limpopo-province-south-africa-a-pilot-study
#6
Aubrey L Doede, Taylor E Allen, JaʼLynn S Gray, Austin G Herbst, Madala C Hlungwani, Nditsheni J Ramakuela, Alice X Xie, Cathy L Campbell
South Africa's rise in noncommunicable diseases (NCDs) and health care provider shortages has generated the need for community health workers (CHWs) in rural areas. However, roles and interactions with clinic staff are not well understood. Interviews with health care workers at community clinics in Limpopo Province revealed common themes, including resource scarcity, clinic-patient partnerships, management of NCDs, and collaboration between professionals. The data did not support CHW-physician interactions, necessitating further research to describe these practices and to evaluate CHWs' impact on patient outcomes...
October 2017: Family & Community Health
https://www.readbyqxmd.com/read/28819863/effects-of-testosterone-treatment-on-hypothalamic-neuroplasticity-in-female-to-male-transgender-individuals
#7
Georg S Kranz, Andreas Hahn, Ulrike Kaufmann, Martin Tik, Sebastian Ganger, René Seiger, Allan Hummer, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger
Diffusion-weighted imaging (DWI) is used to measure gray matter tissue density and white matter fiber organization/directionality. Recent studies show that DWI also allows for assessing neuroplastic adaptations in the human hypothalamus. To this end, we investigated a potential influence of testosterone replacement therapy on hypothalamic microstructure in female-to-male (FtM) transgender individuals. 25 FtMs were measured at baseline, 4 weeks, and 4 months past treatment start and compared to 25 female and male controls...
August 17, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28819733/-the-association-between-allergic-rhinitis-control-and-sleep-quality
#8
R A Gaudin, L P Hoehle, M-A Birkelbach, K M Phillips, A G Beule, D S Caradonna, S T Gray, A R Sedaghat
BACKGROUND: Allergic rhinitis (AR) is the most common form of atopic disease, comprising 50% of atopic diseases. Recently, this disease has increasingly been the focus of intensive research. Previous work has shown that AR has a significant impact on sleep quality. To date there are no published studies demonstrating a quantitative association between the extent of control of AR and the severity of compromised sleep quality. METHODS: Patients with AR were prospectively recruited into our cross-sectional study...
August 17, 2017: HNO
https://www.readbyqxmd.com/read/28819328/synthetic-models-for-nickel-iron-hydrogenase-featuring-redox-active-ligands
#9
David Schilter, Danielle L Gray, Amy L Fuller, Thomas B Rauchfuss
The nickel-iron hydrogenase enzymes efficiently and reversibly interconvert protons, electrons, and dihydrogen. These redox proteins feature iron-sulfur clusters that relay electrons to and from their active sites. Reported here are synthetic models for nickel-iron hydrogenase featuring redox-active auxiliaries that mimic the iron-sulfur cofactors. The complexes prepared are Ni(II)(μ-H)Fe(II)Fe(II) species of formula [(diphosphine)Ni(dithiolate)(μ-H)Fe(CO)2(ferrocenylphosphine)](+) or Ni(II)Fe(I)Fe(II) complexes [(diphosphine)Ni(dithiolate)Fe(CO)2(ferrocenylphosphine)](+) (diphosphine = Ph2P(CH2)2PPh2 or Cy2P(CH2)2PCy2; dithiolate = (-)S(CH2)3S(-); ferrocenylphosphine = diphenylphosphinoferrocene, diphenylphosphinomethyl(nonamethylferrocene) or 1,1'-bis(diphenylphosphino)ferrocene)...
May 2017: Australian Journal of Chemistry
https://www.readbyqxmd.com/read/28818826/test-retest-and-interreader-reproducibility-of-semiautomated-atlas-based-analysis-of-diffusion-tensor-imaging-data-in-acute-cervical-spine-trauma-in-adult-patients
#10
D J Peterson, A M Rutman, D S Hippe, J G Jarvik, F H Chokshi, M R Reyes, C H Bombardier, M Mossa-Basha
BACKGROUND AND PURPOSE: DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS: Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts...
August 17, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28818487/snap-based-incentive-programs-at-farmers-markets-adaptation-considerations-for-temporary-assistance-for-needy-families-tanf-recipients
#11
Marianna S Wetherill, Mary B Williams, Karen A Gray
OBJECTIVE: To describe the design, implementation, and consumer response to a coupon-style intervention aimed to increase Supplemental Nutrition Assistance Program (SNAP) use at a farmers' market (FM) among Temporary Assistance for Needy Families (TANF) participants. DESIGN: A quasi-experimental trial to evaluate redemption response to 2 coupon interventions; baseline surveys characterized coupon redeemers and non-redeemers. SETTING: Urban...
August 14, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28818446/characterization-of-a-highly-selective-inhibitor-of-the-aurora-kinases
#12
Fleur M Ferguson, Zainab M Doctor, Apirat Chaikuad, Taebo Sim, Nam Doo Kim, Stefan Knapp, Nathanael S Gray
Aurora kinases play an essential role in mitosis and cell cycle regulation. In recent years Aurora kinases have proved popular cancer targets and many inhibitors have been developed. The majority of these clinical candidates are multi-targeted, rendering them inappropriate as tools for studying Aurora kinase mediated signaling. Here we report discovery of a highly selective inhibitor of Aurora kinases A, B and C, with potent cellular activity and minimal off-target activity (PLK4). The X-ray co-crystal structure of Aurora A in complex with compound 2 is reported, and provides insights into the structural determinants of ligand binding and selectivity...
August 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28817944/tracking-brain-development-and-dimensional-psychiatric-symptoms-in-children-a-longitudinal-population-based-neuroimaging-study
#13
Ryan L Muetzel, Laura M E Blanken, Jan van der Ende, Hanan El Marroun, Philip Shaw, Gustavo Sudre, Aad van der Lugt, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier, Tonya White
OBJECTIVE: Psychiatric symptomatology during childhood predicts persistent mental illness later in life. While neuroimaging methodologies are routinely applied cross-sectionally to the study of child and adolescent psychopathology, the nature of the relationship between childhood symptoms and the underlying neurodevelopmental processes remains unclear. The authors used a prospective population-based cohort to delineate the longitudinal relationship between childhood psychiatric problems and brain development...
August 18, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28817775/departure-from-a-spherically-symmetric-ground-state-in-a-system-with-a-half-filled-shell-the-case-example-of-berkelium-iv-iodate
#14
Mark A Silver, Samantha K Cary, Alejandro J Garza, Ryan E Baumbach, Alexandra A Arico, Gregory A Galmin, Kuan-Wen Chen, Jason A Johnson, Jamie C Wang, Ronald J Clark, Alexander Chemey, Teresa M Eaton, Matthew L Marsh, Kevin Seidler, Shane S Galley, Lambertus van de Burgt, Ashley L Gray, David E Hobart, Kenneth Hanson, Shelley M van Cleve, Frédéric Gendron, Jochen Autschbach, Gustavo E Scuseria, Laurent Maron, Manfred Speldrich, Paul Kögerler, Cristian Celis-Barros, Dayán Paéz-Hernandéz, Ramiro Arratia-Perez, Michael Ruf, Thomas E Albrecht-Schmitt
The reaction of 249Bk(OH)4 with iodate under hydrothermal conditions results in the formation of Bk(IO3)3 as the major product with trace amounts of Bk(IO3)4 also crystallizing from the reaction mixture. The structure of Bk(IO3)3 consists of nine-coordinate BkIII cations that are bridged by iodate anions to yield layers that are isomorphous with those found for AmIII, CfIII, and with lanthanides that possess similar ionic radii. Bk(IO3)4 was expected to adopt the same structure as M(IO3)4 (M = Ce, Np, Pu), but instead parallels the structural chemistry of the smaller ZrIV cation...
August 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28817596/potential-effects-of-climate-change-on-members-of-the-palaeotropical-pitcher-plant-family-nepenthaceae
#15
Laura K Gray, Charles Clarke, G R William Wint, Jonathan A Moran
Anthropogenic climate change is predicted to have profound effects on species distributions over the coming decades. In this paper, we used maximum entropy modelling (Maxent) to estimate the effects of projected changes in climate on extent of climatically-suitable habitat for two Nepenthes pitcher plant species in Borneo. The model results predicted an increase in area of climatically-suitable habitat for the lowland species Nepenthes rafflesiana by 2100; in contrast, the highland species Nepenthes tentaculata was predicted to undergo significant loss of climatically-suitable habitat over the same period...
2017: PloS One
https://www.readbyqxmd.com/read/28817577/detailing-neuroanatomical-development-in-late-childhood-and-early-adolescence-using-noddi
#16
Alyssa Mah, Bryce Geeraert, Catherine Lebel
Diffusion tensor imaging (DTI) studies have provided much evidence of white and subcortical gray matter changes during late childhood and early adolescence that suggest increasing myelination, axon density, and/or fiber coherence. Neurite orientation dispersion and density imaging (NODDI) can be used to further characterize development in white and subcortical grey matter regions in the brain by improving specificity of the MRI signal compared to conventional DTI. We used measures from NODDI and DTI to examine white and subcortical gray matter development in a group of 27 healthy participants aged 8-13 years...
2017: PloS One
https://www.readbyqxmd.com/read/28817416/nicotinic-modulation-of-descending-pain-control-circuitry
#17
Iboro C Umana, Claire A Daniele, Brooke A Miller, Keith Gallagher, Meghan A Brown, Chandrika Abburi, Peggy Mason, Daniel S McGehee
Along with the well-known rewarding effects, activation of nicotinic acetylcholine receptors (nAChRs) can also relieve pain, and some nicotinic agonists have analgesic efficacy similar to opioids. A major target of analgesic drugs is the descending pain modulatory pathway, including the ventrolateral periaqueductal gray (vlPAG) and the rostral ventromedial medulla (RVM). Although activating nAChRs within this circuitry can be analgesic, little is known about the subunit composition and cellular effects of these receptors, particularly within the vlPAG...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28817411/effects-of-recent-concussion-and-injury-history-on-instantaneous-relative-risk-of-lower-extremity-injury-in-division-i-collegiate-athletes
#18
Peter C Fino, Lauren N Becker, Nora F Fino, Brett Griesemer, Michael Goforth, Per Gunnar Brolinson
BACKGROUND: Growing evidence suggests that concussion increases the risk of lower extremity (LE) musculoskeletal injury. However, it is unclear to how the effect of concussion on LE injury risk may be influenced by previous injuries. This study sought to examine the association between concussion, previous LE injuries, and the risk LE injury to the same previously injured limb (ipsilateral) or the opposite limb (contralateral). METHODS: This retrospective study examined medical records from 110 concussed athletes and 110 matched controls for LE injuries in the 365 days before and after the concussion event...
August 16, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28816271/-construction-and-improvement-of-animal-models-with-different-positional-osseous-metastasis-of-prostate-cancer-in-vivo
#19
Y X Bi, M H Xiao, N N Zhang, X Y Li, X P Mao, K Zhang, Z R Zhang, L Y Zhao
OBJECTIVE: To provide an important tool for the study of diagnose and treatment of prostate cancer (PCa) osseous metastasis and change of bone stress force on prostate cancer (PCa) osseous metastasis and a platform, which is more congruous to clinical process, for prevention and cure of neoplastic bone metastases, and to carry out the construction and improvement of animal models of PCa with different positional osseous metastasis in vivo. METHODS: Different gradient concentrations of RM-1 cells were inoculated into the cavity of left femoral bone or lumbar vertebra of mice (C57BL/6) respectively...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28816138/lymphocyte-nadir-and-esophageal-cancer-survival-outcomes-after-chemoradiation-therapy
#20
Rajayogesh Davuluri, Wen Jiang, Penny Fang, Cai Xu, Ritsuko Komaki, Daniel R Gomez, James Welsh, James D Cox, Christopher H Crane, Charles C Hsu, Steven H Lin
PURPOSE: Host immunity may affect the outcome in patients with esophageal cancer. We sought to identify factors that influenced absolute lymphocyte count (ALC) nadir during chemoradiation therapy (CRT) for esophageal cancer (EC) and looked for clinically relevant associations with survival. METHODS AND MATERIALS: 504 patients with stage I-III EC (2007-2013) treated with neoadjuvant or definitive CRT with weekly ALC determinations made during treatment were analyzed...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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