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https://www.readbyqxmd.com/read/29236300/creepiness-creeps-in-uncanny-valley-feelings-are-acquired-in-childhood
#1
Kimberly A Brink, Kurt Gray, Henry M Wellman
The uncanny valley posits that very human-like robots are unsettling, a phenomenon amply demonstrated in adults but unexplored in children. Two hundred forty 3- to 18-year-olds viewed one of two robots (machine-like or very human-like) and rated their feelings toward (e.g., "Does the robot make you feel weird or happy?") and perceptions of the robot's capacities (e.g., "Does the robot think for itself?"). Like adults, children older than 9 judged the human-like robot as creepier than the machine-like robot-but younger children did not...
December 13, 2017: Child Development
https://www.readbyqxmd.com/read/29235378/the-hexane-fraction-of-bursera-microphylla-a-gray-induces-p21-mediated-anti-proliferative-and-pro-apoptotic-effects-in-human-cancer-derived-cell-lines
#2
Sabrina Adorisio, Alessandra Fierabracci, Giulia Gigliarelli, Isabella Muscari, Lorenza Cannarile, Anna Marina Liberati, Maria Carla Marcotullio, Carlo Riccardi, Massimo Curini, Ramon Enrique Robles Zepeda, Domenico V Delfino
Bursera microphylla (BM), one of the common elephant trees, is widely distributed in the Sonoran Desert in Mexico. The Seri ethnic group in the Sonoran Desert uses BM as an anti-inflammatory and painkiller drug for the treatment of sore throat, herpes labialis, abscessed tooth, and wound healing. Dried stems and leaves of BM are used in a tea to relieve painful urination and to stimulate bronchial secretion. Furthermore, BM is used for fighting venereal diseases. To investigate the effects of the hexane fraction of resin methanol extract (BM-H) on cell growth, the acute myeloid cell line (OCI-AML3) was treated with 250, 25, or 2...
March 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29235194/dual-sensitivity-multiple-sclerosis-lesion-and-csf-segmentation-for-multichannel-3t-brain-mri
#3
Dominik S Meier, Charles R G Guttmann, Subhash Tummala, Nicola Moscufo, Michele Cavallari, Shahamat Tauhid, Rohit Bakshi, Howard L Weiner
BACKGROUND AND PURPOSE: A pipeline for fully automated segmentation of 3T brain MRI scans in multiple sclerosis (MS) is presented. This 3T morphometry (3TM) pipeline provides indicators of MS disease progression from multichannel datasets with high-resolution 3-dimensional T1-weighted, T2-weighted, and fluid-attenuated inversion-recovery (FLAIR) contrast. 3TM segments white (WM) and gray matter (GM) and cerebrospinal fluid (CSF) to assess atrophy and provides WM lesion (WML) volume. METHODS: To address nonuniform distribution of noise/contrast (eg, posterior fossa in 3D-FLAIR) of 3T magnetic resonance imaging, the method employs dual sensitivity (different sensitivities for lesion detection in predefined regions)...
December 13, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29235190/intrinsic-functional-connectivity-of-the-central-extended-amygdala
#4
Rachael M Tillman, Melissa D Stockbridge, Brendon M Nacewicz, Salvatore Torrisi, Andrew S Fox, Jason F Smith, Alexander J Shackman
The central extended amygdala (EAc)-including the bed nucleus of the stria terminalis (BST) and central nucleus of the amygdala (Ce)-plays a critical role in triggering fear and anxiety and is implicated in the development of a range of debilitating neuropsychiatric disorders. Although it is widely believed that these disorders reflect the coordinated activity of distributed neural circuits, the functional architecture of the EAc network and the degree to which the BST and the Ce show distinct patterns of functional connectivity is unclear...
December 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29234959/olfactory-cortex-and-olfactory-bulb-volume-alterations-in-patients-with-post-infectious-olfactory-loss
#5
Linyin Yao, Xiaoli Yi, Jayant Marian Pinto, Xiandao Yuan, Yichen Guo, Yifan Liu, Yongxiang Wei
Upper respiratory tract infection (URI) is one of the most common etiology of olfactory loss. Previous studies demonstrated that both olfactory bulb (OB) volume and sulcus (OS) depth decreased in patients with post-infectious olfactory loss (PIOL) compared to normal controls. The aim of our study was to observe alterations of central olfactory pathways in patients with PIOL. T1 weighted magnetic resonance images were acquired in 19 PIOL patients and 19 age- and sex-matched control subjects on a 3 T scanner...
December 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29234720/radiation-induced-circumscribed-superficial-morphea-after-brachytherapy-for-endometrial-adenocarcinoma
#6
Apoorva Trivedi, Corey M DeWitt, Laura McGevna
Radiation-induced morphea (RIM) is a rare and underrecognized complication of radiation therapy that most commonly occurs in women after treatment for breast cancer. Although not fully understood, RIM is hypothesized to arise from an increase in cytokines that stimulate collagen production and extracellular matrix formation. Most documented cases of RIM occur 1 year after radiation therapy and are localized to areas that were treated for breast cancer. We report on a case of a female patient with stage IB endometrial adenocarcinoma who was treated with 24 Gray of adjuvant brachytherapy...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29234598/investigating-structural-and-perfusion-deficits-due-to-repeated-head-trauma-in-active-professional-fighters
#7
Virendra Mishra, Karthik Sreenivasan, Sarah J Banks, Xiaowei Zhuang, Zhengshi Yang, Dietmar Cordes, Charles Bernick
Repeated head trauma experienced by active professional fighters results in various structural, functional and perfusion damage. However, whether there are common regions of structural and perfusion damage due to fighting and whether these structural and perfusion differences are associated with neuropsychological measurements in active professional fighters is still unknown. To that end, T1-weighted and pseudocontinuous arterial spin labeling MRI on a group of healthy controls and active professional fighters were acquired...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29234585/refractive-index-sensing-and-surface-enhanced-raman-spectroscopy-using-silver-gold-layered-bimetallic-plasmonic-crystals
#8
Somi Kang, Sean E Lehman, Matthew V Schulmerich, An-Phong Le, Tae-Woo Lee, Stephen K Gray, Rohit Bhargava, Ralph G Nuzzo
Herein we describe the fabrication and characterization of Ag and Au bimetallic plasmonic crystals as a system that exhibits improved capabilities for quantitative, bulk refractive index (RI) sensing and surface-enhanced Raman spectroscopy (SERS) as compared to monometallic plasmonic crystals of similar form. The sensing optics, which are bimetallic plasmonic crystals consisting of sequential nanoscale layers of Ag coated by Au, are chemically stable and useful for quantitative, multispectral, refractive index and spectroscopic chemical sensing...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29234095/enclaves-of-genetic-diversity-resisted-inca-impacts-on-population-history
#9
Chiara Barbieri, José R Sandoval, Jairo Valqui, Aviva Shimelman, Stefan Ziemendorff, Roland Schröder, Maria Geppert, Lutz Roewer, Russell Gray, Mark Stoneking, Ricardo Fujita, Paul Heggarty
The Inca Empire is claimed to have driven massive population movements in western South America, and to have spread Quechua, the most widely-spoken language family of the indigenous Americas. A test-case is the Chachapoyas region of northern Peru, reported as a focal point of Inca population displacements. Chachapoyas also spans the environmental, cultural and demographic divides between Amazonia and the Andes, and stands along the lowest-altitude corridor from the rainforest to the Pacific coast. Following a sampling strategy informed by linguistic data, we collected 119 samples, analysed for full mtDNA genomes and Y-chromosome STRs...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233836/radiomic-features-are-superior-to-conventional-quantitative-computed-tomographic-metrics-to-identify-coronary-plaques-with-napkin-ring-sign
#10
Márton Kolossváry, Júlia Karády, Bálint Szilveszter, Pieter Kitslaar, Udo Hoffmann, Béla Merkely, Pál Maurovich-Horvat
BACKGROUND: Napkin-ring sign (NRS) is an independent prognostic imaging marker of major adverse cardiac events. However, identification of NRS is challenging because of its qualitative nature. Radiomics is the process of extracting thousands of quantitative parameters from medical images to create big-data data sets that can identify distinct patterns in radiological images. Therefore, we sought to determine whether radiomic analysis improves the identification of NRS plaques. METHODS AND RESULTS: From 2674 patients referred to coronary computed tomographic angiography caused by stable chest pain, expert readers identified 30 patients with NRS plaques and matched these with 30 non-NRS plaques with similar degree of calcification, luminal obstruction, localization, and imaging parameters...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29233827/stress-echocardiography-positivity-predicts-cancer-death
#11
Clara Carpeggiani, Patrizia Landi, Claudio Michelassi, Maria Grazia Andreassi, Rosa Sicari, Eugenio Picano
BACKGROUND: Stress echocardiography (SE) predicts cardiac death, but an increasing share of cardiac patients eventually die of cancer. The aim of the study was to assess whether SE positivity predicts cancer death. METHODS AND RESULTS: In a retrospective analysis of prospectively acquired single-center, observational data, we evaluated 4673 consecutive patients who underwent SE from 1983 to 2009. All patients were cancer-free at index SE and were followed up for a median of 131 months (interquartile range 134)...
December 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29233664/performance-of-a-prostate-cancer-genomic-classifier-in-predicting-metastasis-in-men-with-prostate-specific-antigen-persistence-postprostatectomy
#12
Daniel E Spratt, Darlene L Y Dai, Robert B Den, Patricia Troncoso, Kasra Yousefi, Ashley E Ross, Edward M Schaeffer, Zaid Haddad, Elai Davicioni, Rohit Mehra, Todd M Morgan, Walter Rayford, Firas Abdollah, Edouard Trabulsi, Mary Achim, Elsa Li Ning Tapia, Mireya Guerrero, Robert Jeffrey Karnes, Adam P Dicker, Mark A Hurwitz, Paul L Nguyen, Felix F Y Feng, Stephen J Freedland, John W Davis
BACKGROUND: Prostate cancer patients who have a detectable prostate-specific antigen (PSA) postprostatectomy may harbor pre-existing metastatic disease. To our knowledge, none of the commercially available genomic biomarkers have been investigated in such men. OBJECTIVE: To evaluate if a 22-gene genomic classifier can independently predict development of metastasis in men with PSA persistence postoperatively. DESIGN, SETTING, AND PARTICIPANTS: A multi-institutional study of 477 men who underwent radical prostatectomy (RP) between 1990 and 2015 from three academic centers...
December 9, 2017: European Urology
https://www.readbyqxmd.com/read/29233167/interventions-for-domestic-violence-among-pregnant-women-in-low-and-middle-income-countries-a-systematic-review-protocol
#13
Diksha Sapkota, Kathleen Baird, Amornrat Saito, Debra Anderson
BACKGROUND: Violence during pregnancy is a global problem, associated with serious health risks for both the mother and baby. Evaluation of interventions targeted for reducing or controlling domestic violence (DV) is still in its infancy, and the majority of findings are primarily from high-income countries (HICs). Therefore, there is an urgent need for generating evidence of DV interventions among pregnant women in low- and middle-income countries (LMICs). METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be employed to structure the review...
December 12, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29232965/structural-and-functional-changes-in-the-somatosensory-cortex-in-euthymic-females-with-bipolar-disorder
#14
Luciano Minuzzi, Sabrina K Syan, Mara Smith, Alexander Hall, Geoffrey Bc Hall, Benicio N Frey
OBJECTIVE: Current evidence from neuroimaging data suggests possible dysfunction of the fronto-striatal-limbic circuits in individuals with bipolar disorder. Somatosensory cortical function has been implicated in emotional recognition, risk-taking and affective responses through sensory modalities. This study investigates anatomy and function of the somatosensory cortex in euthymic bipolar women. METHODS: In total, 68 right-handed euthymic women (bipolar disorder = 32 and healthy controls = 36) between 16 and 45 years of age underwent high-resolution anatomical and functional magnetic resonance imaging during the mid-follicular menstrual phase...
December 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/29232264/fish-oil-derived-n-3-polyunsaturated-fatty-acids-for-the-prevention-and-treatment-of-sarcopenia
#15
Stuart R Gray, Bettina Mittendorfer
PURPOSE OF REVIEW: Muscle mass and function decline progressively starting in middle age, which can result in sarcopenia and affect people's mobility and independence later in life. Exercise training and increased protein intake are typically recommended to counteract the age-associated decline in muscle mass and function. However, few people comply with exercise recommendations and the effectiveness of high-protein intake to halt the decline in muscle mass and function has not been proven...
December 9, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29230928/audiological-monitoring-in-swiss-childhood-cancer-patients
#16
Annette Weiss, Rahel Kuonen, Hanna Brockmeier, Michael Grotzer, Claudia Candreia, Raphael Maire, Pascal Senn, Christof Stieger, Jochen Rosenfeld, Dorothe Veraguth, Martin Kompis, Katrin Scheinemann, Claudia E Kuehni
BACKGROUND: Full audiological monitoring is the best strategy to detect hearing loss early and to provide timely intervention in the absence of a clinical method of otoprotection. Full monitoring requires audiological evaluation before, and then during and after ototoxic cancer treatment. In a worldwide context of monitoring protocols that vary substantially, we analyzed the audiological monitoring of childhood cancer patients over the last decade across treatment centers in Switzerland...
December 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29230507/evidence-for-regional-hippocampal-damage-in-patients-with-schizophrenia
#17
Sadhana Singh, Subash Khushu, Pawan Kumar, Satnam Goyal, Triptish Bhatia, Smita N Deshpande
PURPOSE: Schizophrenia patients show cognitive and mood impairments, including memory loss and depression, suggesting damage in the brain regions. The hippocampus is a brain structure that is significantly involved in memory and mood function and shows impairment in schizophrenia. In the present study, we examined the regional hippocampal changes in schizophrenia patients using voxel-based morphometry (VBM), Freesurfer, and proton magnetic resonance spectroscopy (1H MRS) procedures. METHODS: 1H MRS and high-resolution T1-weighted magnetic resonance imaging were collected in both healthy control subjects (N = 28) and schizophrenia patients (N = 28) using 3-Tesla whole body MRI system...
December 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29230292/multiple-steroid-and-thyroid-hormones-detected-in-baleen-from-eight-whale-species
#18
Kathleen E Hunt, Nadine S Lysiak, Jooke Robbins, Michael J Moore, Rosemary E Seton, Leigh Torres, C Loren Buck
Recent studies have demonstrated that some hormones are present in baleen powder from bowhead (Balaena mysticetus) and North Atlantic right (Eubalaena glacialis) whales. To test the potential generalizability of this technique for studies of stress and reproduction in large whales, we sought to determine whether all major classes of steroid and thyroid hormones are detectable in baleen, and whether these hormones are detectable in other mysticetes. Powdered baleen samples were recovered from single specimens of North Atlantic right, bowhead, blue (Balaenoptera [B...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29230194/acute-flaccid-paralysis-by-enterovirus-d68-infection-first-italian-description-in-adult-patient-and-role-of-electrophysiology
#19
Marco Ceccanti, Emilia Sbardella, Federica Letteri, Manuela De Michele, Anne Falcou, Federica Romanzi, Emanuela Onesti, Maurizio Inghilleri
A Peruvian woman was admitted to the Emergency Department, due to an acute flaccid paralysis (AFP) of the upper limbs that progressively involved also lower limbs and respiratory muscles. She previously suffered from non-Hodgkin's lymphoma and had to undergo hematopoietic stem cell transplantation. A magnetic resonance imaging showed a T2 hyperintensity in the anterior and central region of the cervical segment with an elective involvement of gray matter. This finding, combined with other clinical, laboratory, and electrophysiological data, led to a diagnosis of AFP...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230059/genome-wide-association-study-of-delay-discounting-in-23-217-adult-research-participants-of-european-ancestry
#20
Sandra Sanchez-Roige, Pierre Fontanillas, Sarah L Elson, Anita Pandit, Ellen M Schmidt, Johanna R Foerster, Gonçalo R Abecasis, Joshua C Gray, Harriet de Wit, Lea K Davis, James MacKillop, Abraham A Palmer
Delay discounting (DD), the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated single-nucleotide polymorphism was rs6528024 (P = 2.40 × 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition and body weight...
December 11, 2017: Nature Neuroscience
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