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https://www.readbyqxmd.com/read/28454039/land-cover-change-during-a-period-of-extensive-landscape-restoration-in-ningxia-hui-autonomous-region-china
#1
Angela M Cadavid Restrepo, Yu Rong Yang, Nicholas A S Hamm, Darren J Gray, Tamsin S Barnes, Gail M Williams, Ricardo J Soares Magalhães, Donald P McManus, Danhuai Guo, Archie C A Clements
Environmental change has been a topic of great interest over the last century due to its potential impact on ecosystem services that are fundamental for sustainable development and human well-being. Here, we assess and quantify the spatial and temporal variation in land cover in Ningxia Hui Autonomous Region (NHAR), China. With high-resolution (30m) imagery from Landsat 4/5-TM and 8-OLI for the entire region, land cover maps of the region were created to explore local land cover changes in a spatially explicit way...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453693/racial-disparities-in-prostate-cancer-outcome-among-prostate-specific-antigen-screening-eligible-populations-in-the-united-states
#2
B A Mahal, Y-W Chen, V Muralidhar, A R Mahal, T K Choueiri, K E Hoffman, J C Hu, C J Sweeney, J B Yu, F Y Feng, S P Kim, C J Beard, N E Martin, Q-D Trinh, P L Nguyen
Background: In 2012, the United States Preventive Services Task Force (USPSTF) recommended against prostate-specific antigen (PSA) screening, despite evidence that Black men are at a higher risk of prostate cancer-specific mortality (PCSM). We evaluated whether Black men of potentially screening-eligible age (55-69 years) are at a disproportionally high risk of poor outcomes. Patients and methods: The SEER database was used to study 390 259 men diagnosed with prostate cancer in the United States between 2004 and 2011...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453469/use-of-analgesics-opioids-and-nonsteroidal-anti-inflammatory-drugs-and-dementia-related-neuropathology-in-a-community-based-autopsy-cohort
#3
Sascha Dublin, Rod L Walker, Shelly L Gray, Rebecca A Hubbard, Melissa L Anderson, Onchee Yu, Thomas J Montine, Paul K Crane, Josh A Sonnen, Eric B Larson
BACKGROUND: Opioids may influence the development of Alzheimer's disease (AD). Some studies have observed AD pathology in the brains of opioid abusers. No study has examined the association between prescription opioid use and dementia-related neuropathologic changes. OBJECTIVE: To examine the relationship between prescription opioid or NSAID use and dementia-related neuropathologic changes. METHODS: Within a community-based autopsy cohort (N = 420), we ascertained opioid and nonsteroidal anti-inflammatory drug (NSAID) use over a 10-year period from automated pharmacy data and calculated total standardized daily doses (TSDDs)...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28448234/leveraging-clinical-imaging-archives-for-radiomics-reliability-of-automated-methods-for-brain-volume-measurement
#4
Viraj R Adduru, Andrew M Michael, Maria Helguera, Stefi A Baum, Gregory J Moore
Purpose To validate the use of thick-section clinically acquired magnetic resonance (MR) imaging data for estimating total brain volume (TBV), gray matter (GM) volume (GMV), and white matter (WM) volume (WMV) by using three widely used automated toolboxes: SPM ( www.fil.ion.ucl.ac.uk/spm/ ), FreeSurfer ( surfer.nmr.mgh.harvard.edu ), and FSL (FMRIB software library; Oxford Centre for Functional MR Imaging of the Brain, Oxford, England, https://fsl.fmrib.ox.ac.uk/fsl ). Materials and Methods MR images from a clinical archive were used and data were deidentified...
April 27, 2017: Radiology
https://www.readbyqxmd.com/read/28448162/joblessness-and-lost-earnings-after-ards-in-a-1-year-national-multicenter-study
#5
Biren B Kamdar, Minxuan Huang, Victor D Dinglas, Elizabeth Colantuoni, Till M von Wachter, Ramona O Hopkins, Dale M Needham
RATIONALE: Following acute respiratory distress syndrome (ARDS), joblessness is common, but poorly understood. OBJECTIVES: To evaluate the timing of return to work following ARDS, and associated risk factors, lost earnings, and changes in healthcare coverage Methods: Over 12-month longitudinal follow-up, ARDS survivors from 43 U.S. ARDSNet hospitals provided employment and healthcare coverage data via structured telephone interviews. Factors associated with the timing of return to work were assessed using Fine and Gray regression analysis...
April 27, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28448137/profiling-the-phenolic-compounds-of-the-four-major-seed-coat-types-and-their-relation-to-color-genes-in-lentil
#6
Mahla Mirali, Randy W Purves, Albert Vandenberg
Phenolic compounds can provide antioxidant health benefits for humans, and foods such as lentils can be valuable dietary sources of different subclasses of these secondary metabolites. This study used LC-MS analyses to compare the phenolic profiles of lentil genotypes with four seed coat background colors (green, gray, tan, and brown) and two cotyledon colors (red and yellow) grown at two locations. The mean area ratio per mg sample (MARS) values of various phenolic compounds in lentil seeds varied with the different seed coat colors conferred by specific genotypes...
April 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28448072/evaluation-of-ptgs2-expression-pik3ca-mutation-aspirin-use-and-colon-cancer-survival-in-a-population-based-cohort-study
#7
Ronan T Gray, Marie M Cantwell, Helen G Coleman, Maurice B Loughrey, Peter Bankhead, Stephen McQuaid, Roisin F O'Neill, Kenneth Arthur, Victoria Bingham, Claire McGready, Anna T Gavin, Chris R Cardwell, Brian T Johnston, Jacqueline A James, Peter W Hamilton, Manuel Salto-Tellez, Liam J Murray
OBJECTIVES: The association between aspirin use and improved survival after colorectal cancer diagnosis may be more pronounced in tumors that have PIK3CA mutations or high PTGS2 expression. However, the evidence of a difference in association by biomarker status lacks consistency. In this population-based colon cancer cohort study the interaction between these biomarkers, aspirin use, and survival was assessed. METHODS: The cohort consisted of 740 stage II and III colon cancer patients diagnosed between 2004 and 2008...
April 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28448005/open-source-single-particle-analysis-for-super-resolution-microscopy-with-virusmapper
#8
Robert D M Gray, Jason Mercer, Ricardo Henriques
Super-resolution fluorescence microscopy is currently revolutionizing cell biology research. Its capacity to break the resolution limit of around 300 nm allows for the routine imaging of nanoscale biological complexes and processes. This increase in resolution also means that methods popular in electron microscopy, such as single-particle analysis, can readily be applied to super-resolution fluorescence microscopy. By combining this analytical approach with super-resolution optical imaging, it becomes possible to take advantage of the molecule-specific labeling capacity of fluorescence microscopy to generate structural maps of molecular elements within a metastable structure...
April 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447880/resistance-training-in-youth-laying-the-foundation-for-injury-prevention-and-physical-literacy
#9
Christin Zwolski, Catherine Quatman-Yates, Mark V Paterno
CONTEXT: The rising incidence of physical activity- and sports-related injuries has prompted the present-day investigation of resistance training as a potential means of injury prevention and physical literacy development among youth. EVIDENCE ACQUISITION: Relevant studies on the topics of athlete development, physical literacy, resistance training, and injury prevention in children and adolescents were reviewed (PubMed and Sports Discus, 1982-2016). Recommendations from consensus guidelines and position statements applicable to resistance training and injury prevention in youth, in addition to young athlete development, were reviewed...
April 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28447710/khorana-score-and-histotype-predicts-incidence-of-early-venous-thromboembolism-in-non-hodgkin-lymphomas-a-pooled-data-analysis-of-12-clinical-trials-of-fondazione-italiana-linfomi-fil
#10
Roberto Mario Santi, Manuela Ceccarelli, Elisa Bernocco, Chiara Monagheddu, Andrea Evangelista, Federica Valeri, Federico Monaco, Umberto Vitolo, Sergio Cortelazzo, Maria Giuseppina Cabras, Michele Spina, Luca Baldini, Carola Boccomini, Annalisa Chiappella, Alessia Bari, Stefano Luminari, Carlo Visco, Marco Calabrese, Giulia Limberti, Alessandro Levis, Laura Contino, Giovannino Ciccone, Marco Ladetto
Current data suggests that the risk of venous thromboembolism (VTE) in patients with non-Hodgkin lymphoma (NHL) is comparable to that observed in patients with solid tumours, although more robust confirmatory analyses are required. With that in mind, we investigated the occurrence of VTE in a pooled analysis of 12 "Fondazione Italiana Linfomi" (FIL) prospective clinical studies. Specifically, we wished to assess the cumulative incidence of VTE in NHL patients, evaluate the predictive value of the Khorana Score (KS), and identify other potential risk factors for VTEs...
April 27, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28447351/estimating-melanin-location-in-the-pigmented-skin-lesions-by-hue-saturation-lightness-color-space-values-of-dermoscopic-images
#11
REVIEW
Hiroshi Sakai, Yoshimi Ando, Kuniko Ikinaga, Masaru Tanaka
The depth of melanin in the skin can be estimated roughly by observation of the color exhibited on dermoscopy. Currently, there are no objective methods to estimate it. The aim of the present study was to clarify the relationship between the depth of melanin in the skin and the color variation exhibited, and to objectively estimate the 3-D location of melanin in the pigmented skin lesions from dermoscopic images. Representative colors in dermoscopic images of acral compound nevus, Spitz nevus and blue nevus were evaluated by the subjectively perceived color on dermoscopy and objective values in hue-saturation-lightness color space values...
May 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28447245/neuroanatomical-variations-as-a-function-of-experience-in-a-complex-daily-task-a-vbm-and-dti-study-on-driving-experience
#12
Alberto Megías, D Petrova, J F Navas, A Cándido, A Maldonado, A Catena
Complex tasks require the learning and integration of multiple cognitive, sensory, and psychomotor skills for correct execution. Driving-related skills are developed step by step through the increase of mileage driven and the accumulation of practice in different traffic situations. The acquisition of these skills should be reflected in the brain structure. However, no previous studies have explored brain structural variations associated with driving experience. The aim of the present study was to investigate whether driving frequency, defined as average annual driving mileage, is related to neuroanatomical variations in gray matter (GM) volume and white matter (WM) integrity using voxel-based morphometry (VBM) and DTI-based fractional anisotropy (FA), respectively...
April 26, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28446756/a-chemically-patterned-microfluidic-paper-based-analytical-device-c-%C3%A2%C2%B5pad-for-point-of-care-diagnostics
#13
Trinh Lam, Jasmine P Devadhasan, Ryan Howse, Jungkyu Kim
A chemically patterned microfluidic paper-based analytical device (C-µPAD) is developed to create fluidic networks by forming hydrophobic barriers using chemical vapor deposition (CVD) of trichlorosilane (TCS) on a chromatography paper. By controlling temperature, pattern size, and CVD duration, optimal conditions were determined by characterizing hydrophobicity, spreading patterns, and flow behavior on various sized fluidic patterns. With these optimal conditions, we demonstrated glucose assay, immunoassay, and heavy metal detection on well-spot C-µPAD and lateral flow C-µPAD...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446652/asymptomatic-carotid-stenosis-medicine-alone-or-combined-with-carotid-revascularization
#14
REVIEW
Donald V Heck, Gary S Roubin, Kenneth G Rosenfield, William A Gray, Christopher J White, Tudor G Jovin, Jon S Matsumura, Brajesh K Lal, Barry T Katzen, Guilherme Dabus, Brian T Jankowitz, Thomas G Brott
Two positive randomized trials established carotid endarterectomy (CEA) as a superior treatment to medical management alone for the treatment of asymptomatic carotid artery stenosis. However, advances in medical therapy have led to an active and spirited debate about the best treatment for asymptomatic carotid stenosis. The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis (CREST 2) trial aims to better define the best treatment for the average patient with severe asymptomatic carotid stenosis...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28446585/activation-mechanism-of-a-neuromodulator-gated-pacemaker-ionic-current
#15
Michael Gray, Daniel Hector Daudelin, Jorge Golowasch
The neuromodulator-gated current (IMI) found in the crab stomatogastric ganglion is activated by neuromodulators that are essential to induce the rhythmic activity of the pyloric network in this system. One of these neuromodulators is also known to control the correlated expression of voltage-gated ionic currents in pyloric neurons as well as synaptic plasticity and strength. Thus, understanding the mechanism by which neuromodulator receptors activate IMI should provide insights not only into how oscillations are initiated, but also into how other processes, and currents not directly activated by them, are regulated...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28446242/activity-of-distinct-growth-factor-receptor-network-components-in-breast-tumors-uncovers-two-biologically-relevant-subtypes
#16
Mumtahena Rahman, Shelley M MacNeil, David F Jenkins, Gajendra Shrestha, Sydney R Wyatt, Jasmine A McQuerry, Stephen R Piccolo, Laura M Heiser, Joe W Gray, W Evan Johnson, Andrea H Bild
BACKGROUND: The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors. Here, pathway-specific genomic signatures were used to interrogate GFRN activity in breast tumors and the consequent phenotypic impact of GRFN activity patterns. METHODS: Novel pathway signatures were generated in human primary mammary epithelial cells by overexpressing key genes from GFRN pathways (HER2, IGF1R, AKT1, EGFR, KRAS (G12V), RAF1, BAD)...
April 26, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28445885/patterns-of-microglial-cell-activation-in-alzheimer-disease-and-frontotemporal-lobar-degeneration
#17
Ricardo Taipa, Paulo Brochado, Andrew Robinson, Inês Reis, Patrício Costa, David M Mann, Manuel Melo Pires, Nuno Sousa
AIMS: Microglia-driven neuroinflammation can play an important role in the pathophysiology of neurodegenerative disorders. In this study, we sought to characterize the distribution of microglial cell activation in 2 neurodegenerative dementias with distinct protein signatures, Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) of the TDP subtype, and to determine if there was an anatomical correlation with the phenotypes most commonly associated with these conditions...
April 27, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28445263/acupuncture-for-enhancing-early-recovery-of-bowel-function-in-cancer-protocol-for-a-systematic-review
#18
Yi-Hua Liu, Yang Ye, Jia-Bin Zheng, Xue-Qian Wang, Ying Zhang, Hong-Sheng Lin
BACKGROUND: Cancer patients undergoing surgical procedure often suffer from bowel dysfunction and postoperative ileus (POI). Cancer management for early recovery of bowel function is still a challenging topic. Acupuncture has been commonly used in a variety of gastrointestinal diseases. The aim of this study is to evaluate the effects of acupuncture therapy to reduce the duration of POI and enhance bowel function in cancer patients. METHODS: We will systematically screen all randomized controlled trials (RCTs) published through electronically and hand searching...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445216/opposition-to-obamacare-a-closer-look
#19
Paul R Gordon, Laurel Gray, Alex Hollingsworth, Eve C Shapiro, James E Dalen
Prior telephone surveys have reported two main reasons for opposition to the Affordable Care Act (ACA): distrust of government and opposition to the universal coverage mandate. The authors set out to elucidate the reasons for this opposition. This article describes how the authors used qualitative methods with semistructured interviewing as a principal investigative method to gather information from people they met while bicycling across the United States from April through July 2016. During this time, the authors conducted open-ended, semistructured conversations with people they met as they rode their bicycles from Washington, DC, to Seattle, Washington...
April 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28445044/highly-oxygenated-multifunctional-compounds-in-%C3%AE-pinene-secondary-organic-aerosol
#20
Xuan Zhang, Andrew T Lambe, Mary Alice Upshur, William A Brooks, Ariana Gray Be, Regan J Thomson, Franz M Geiger, Jason Douglas Surratt, Zhenfa Zhang, Avram Gold, Stephan Graf, Michael J Cubison, Michael Groessl, John T Jayne, Douglas R Worsnop, Manjula R Canagaratna
Highly oxygenated multifunctional organic compounds (HOMs) originating from biogenic emissions constitute a widespread source of organic aerosols in the pristine atmosphere. Yet, the molecular forms in which HOMs are present in the condensed phase upon gas-particle partitioning remain unclear. In this study, we show that highly oxygenated molecules that contain multiple peroxide functionalities are readily cationized by the attachment of Na(+) during electrospray ionization operated in the positive ion mode...
April 26, 2017: Environmental Science & Technology
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