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https://www.readbyqxmd.com/read/28340519/barrington-s-nucleus-neuroanatomic-landscape-of-the-mouse-pontine-micturition-center
#1
Anne M J Verstegen, Veronique Vanderhorst, Paul A Gray, Mark L Zeidel, Joel C Geerling
Barrington's nucleus (Bar) is thought to contain neurons that trigger voiding and thereby function as the "pontine micturition center." Lacking detailed information on this region in mice, we examined gene and protein markers to characterize Bar and the neurons surrounding it. Like rats and cats, mice have an ovoid core of medium-sized Bar neurons located medial to the locus coeruleus (LC). Bar neurons express a GFP reporter for Vglut2, develop from a Math1/Atoh1 lineage, and exhibit immunoreactivity for NeuN...
March 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28340448/structural-correlates-of-creative-thinking-in-patients-with-bipolar-disorder-and-healthy-controls-a-voxel-based-morphometry-study
#2
Pei-Chi Tu, Yi-Hsuan Kuan, Cheng-Ta Li, Tung-Ping Su
BACKGROUND: This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. METHODS: We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association...
March 12, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28340084/the-feasibility-and-implications-of-limiting-red-blood-cell-transfusions-to-units-less-than-35-days-old
#3
Tiffany Graham, Daniel B Peavey, Tammy Gray, Marisa B Marques
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28340083/evaluating-the-patterns-of-aging-related-tau-astrogliopathy-unravels-novel-insights-into-brain-aging-and-neurodegenerative-diseases
#4
Gabor G Kovacs, John L Robinson, Sharon X Xie, Edward B Lee, Murray Grossman, David A Wolk, David J Irwin, Dan Weintraub, Christopher F Kim, Theresa Schuck, Ahmed Yousef, Stephanie T Wagner, Eunran Suh, Vivianna M Van Deerlin, Virginia M-Y Lee, John Q Trojanowski
The term "aging-related tau astrogliopathy" (ARTAG) describes pathological accumulation of abnormally phosphorylated tau protein in astrocytes. We evaluated the correlates of ARTAG types (i.e., subpial, subependymal, white and gray matter, and perivascular) in different neuroanatomical regions. Clinical, neuropathological, and genetic (eg, APOE ε4 allele, MAPT H1/H2 haplotype) data from 628 postmortem brains from subjects were investigated; most of the patients had been longitudinally followed at the University of Pennsylvania...
March 14, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28339675/high-reported-rates-of-antimicrobial-resistance-in-indian-neonatal-and-pediatric-blood-stream-infections
#5
Dhanya Dharmapalan, Anita Shet, Vijay Yewale, Mike Sharland
Background.: There is real shortage of national data on antimicrobial resistance rates in Indian neonates and children. A descriptive review was conducted to determine the patterns of antimicrobial resistance in isolates of blood stream infection among hospitalized children in India. Methods.: Published and gray literature on antibiotic resistance in children was searched using "Google Scholar", "Scopus", and "PubMed" databases between January 2000 and July 2015...
February 18, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339428/does-conservative-treatment-change-the-brain-in-patients-with-chronic-musculoskeletal-pain-a-systematic-review
#6
Jeroen Kregel, Iris Coppieters, Robby DePauw, Anneleen Malfliet, Lieven Danneels, Jo Nijs, Barbara Cagnie, Mira Meeus
BACKGROUND: Chronic musculoskeletal pain is characterized by maladaptive central neuroplastic changes. Many observational studies have demonstrated that chronic pain states are associated with brain alterations regarding structure and/or function. Rehabilitation of patients with chronic musculoskeletal pain may include cognitive, exercise, or multimodal therapies. OBJECTIVE: The current review aims to provide a constructive overview of the existing literature reporting neural correlates, based on brain magnetic resonance imaging (MRI) techniques, following conservative treatment in chronic musculoskeletal pain patients...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339397/cognitive-status-gray-matter-atrophy-and-lower-orthostatic-blood-pressure-in-older-adults
#7
Celia O'Hare, Rose-Anne Kenny, Howard Aizenstein, Robert Boudreau, Anne Newman, Lenore Launer, Suzanne Satterfield, Kristine Yaffe, Caterina Rosano
BACKGROUND: Associations between orthostatic blood pressure and cognitive status (CS) have been described with conflicting results. OBJECTIVE: We hypothesize that long-term exposure to lower orthostatic blood pressure is related to having worse CS later in life and that atrophy of regions involved in central regulation of autonomic function mediate these associations. METHODS: Three-to-four measures of orthostatic blood pressure were obtained from 1997-2003 in a longitudinal cohort of aging, and average systolic orthostatic blood pressure response (ASOBPR) was computed as % change in systolic blood pressure from sit-to-stand measured at one minute post stand...
March 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28335482/improved-wallis-dodging-algorithm-for-large-scale-super-resolution-reconstruction-remote-sensing-images
#8
Chong Fan, Xushuai Chen, Lei Zhong, Min Zhou, Yun Shi, Yulin Duan
A sub-block algorithm is usually applied in the super-resolution (SR) reconstruction of images because of limitations in computer memory. However, the sub-block SR images can hardly achieve a seamless image mosaicking because of the uneven distribution of brightness and contrast among these sub-blocks. An effectively improved weighted Wallis dodging algorithm is proposed, aiming at the characteristic that SR reconstructed images are gray images with the same size and overlapping region. This algorithm can achieve consistency of image brightness and contrast...
March 18, 2017: Sensors
https://www.readbyqxmd.com/read/28335340/recent-advances-in-chiral-nematic-structure-and-iridescent-color-of-cellulose-nanocrystal-films
#9
REVIEW
Derek G Gray
One unique property of cellulose nanocrystals (CNC) is their property of forming suspensions with chiral nematic order. This order can be preserved in films cast from the suspensions, raising the possibility of applications as photonic materials and templates. However, it has proved difficult to generate uniform, well-ordered chiral nematic materials from CNC. Recently, the importance of kinetic arrest due to gel formation in the later stages of evaporation has been recognized as a key step in film formation...
November 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334252/individualized-prediction-of-reading-comprehension-ability-using-gray-matter-volume
#10
Zaixu Cui, Mengmeng Su, Liangjie Li, Hua Shu, Gaolang Gong
Reading comprehension is a crucial reading skill for learning and putatively contains 2 key components: reading decoding and linguistic comprehension. Current understanding of the neural mechanism underlying these reading comprehension components is lacking, and whether and how neuroanatomical features can be used to predict these 2 skills remain largely unexplored. In the present study, we analyzed a large sample from the Human Connectome Project (HCP) dataset and successfully built multivariate predictive models for these 2 skills using whole-brain gray matter volume features...
March 10, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28334227/a-phylogenetic-biogeographic-and-taxonomic-study-of-all-extant-species-of-anolis-squamata-iguanidae
#11
Steven Poe, Adrián Nieto-Montes de Oca, Omar Torres-Carvajal, Kevin de Queiroz, Julián A Velasco, Brad Truett, Levi N Gray, Mason J Ryan, Gunther Köhler, Fernando Ayala-Varela, Ian Latella
Anolis lizards (anoles) are textbook study organisms in evolution and ecology. Although several topics in evolutionary biology have been elucidated by the study of anoles, progress in some areas has been hampered by limited phylogenetic information on this group. Here we present a phylogenetic analysis of all 379 extant species of Anolis, with new phylogenetic data for 139 species including new DNA data for 101 species. We use the resulting estimates as a basis for defining anole clade names under the principles of phylogenetic nomenclature and to examine the biogeographic history of anoles...
February 27, 2017: Systematic Biology
https://www.readbyqxmd.com/read/28333485/visual-acuity-in-the-striped-skunk-mephitis-mephitis
#12
Zoe Johnson-Ulrich, Eric Hoffmaster, Audrey Robeson, Jennifer Vonk
The visual acuity of striped skunks (Mephitis mephitis) was tested using a 2 alternative forced-choice task with square wave gratings. Skunks were reinforced with food items for touching a ball in front of a striped stimulus when paired with a ball in front of a solid gray stimulus. Skunks demonstrated a maximum visual acuity of 0.42 cycles per degree when tested with bright outdoor illumination. This poor visual acuity may be due to their nocturnal lifestyle, lack of predation, and is consistent with their preferential use of smell and sound during foraging...
March 23, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28333338/drug-discovery-for-male-subfertility-using-high-throughput-screening-a-new-approach-to-an-unsolved-problem
#13
Sarah J Martins da Silva, Sean G Brown, Keith Sutton, Louise V King, Halil Ruso, David W Gray, Paul G Wyatt, Mark C Kelly, Christopher L R Barratt, Anthony G Hope
STUDY QUESTION: Can pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility? SUMMARY ANSWER: High-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor infertility. WHAT IS KNOWN ALREADY: There is both huge demand and a genuine clinical need for new treatment options for infertile men. However, the time, effort and resources required for drug discovery are currently exorbitant, due to the unique challenges of the cellular, physical and functional properties of human spermatozoa and a lack of appropriate assay platform...
March 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333330/genomic-landscape-of-extended-spectrum-%C3%AE-lactamase-resistance-in-escherichia-coli-from-an-urban-african-setting
#14
Patrick Musicha, Nicholas A Feasey, Amy K Cain, Teemu Kallonen, Chrispin Chaguza, Chikondi Peno, Margaret Khonga, Sarah Thompson, Katherine J Gray, Alison E Mather, Robert S Heyderman, Dean B Everett, Nicholas R Thomson, Chisomo L Msefula
Objectives: Efforts to treat Escherichia coli infections are increasingly being compromised by the rapid, global spread of antimicrobial resistance (AMR). Whilst AMR in E. coli has been extensively investigated in resource-rich settings, in sub-Saharan Africa molecular patterns of AMR are not well described. In this study, we have begun to explore the population structure and molecular determinants of AMR amongst E. coli isolates from Malawi. Methods: Ninety-four E...
March 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28333019/a-comparison-between-low-dose-rate-brachytherapy-with-or-without-androgen-deprivation-external-beam-radiation-therapy-with-or-without-androgen-deprivation-and-radical-prostatectomy-with-or-without-adjuvant-or-salvage-radiation-therapy-for-high-risk-prostate
#15
Jay P Ciezki, Michael Weller, Chandana A Reddy, Jeffrey Kittel, Harguneet Singh, Rahul Tendulkar, Kevin L Stephans, James Ulchaker, Kenneth Angermeier, Andrew Stephenson, Steven Campbell, Georges-Pascal Haber, Eric A Klein
PURPOSE: We compare the efficacy and toxicity among the 3 major modalities available used to treat high-risk prostate cancer (HRCaP). METHODS AND MATERIALS: From 1996 to 2012, 2557 HRCaP patients were treated: 734 received external beam radiation therapy (EBRT) with or without androgen deprivation therapy (ADT), 515 received low-dose-rate prostate brachytherapy (LDR) with or without ADT, and 1308 received radical prostatectomy (RP) with or without EBRT. Biochemical relapse-free survival (bRFS), clinical relapse-free survival (cRFS), and prostate cancer-specific mortality (PCSM) were assessed...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332705/global-brain-asymmetry-is-increased-in-schizophrenia-and-related-to-avolition
#16
C Núñez, N Paipa, C Senior, M Coromina, S Siddi, S Ochoa, G Brébion, C Stephan-Otto
OBJECTIVE: Schizophrenia may be the result of a failure of the normal lateralization process of the brain. However, whole-brain asymmetry has not been assessed up to date. Here, we propose a novel measure of global brain asymmetry based on the Dice coefficient to quantify similarity between brain hemispheres. METHOD: Global gray and white matter asymmetry was calculated from high-resolution T1 structural images acquired from 24 patients with schizophrenia and 26 healthy controls, age- and sex-matched...
March 23, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28332474/brain-swelling-during-dialysis-a-randomized-trial-comparing-low-flux-hemodialysis-with-pre-dilution-hemodiafiltration%C3%A2
#17
Niels Johansen, Krista Dybtved Kjaergaard, Christian Daugaard Peters, Michael Pedersen, Bente Jespersen, Jens Dam Jensen
Osmotic changes in plasma are assumed to cause cerebral swelling in hemodialysis patients. We investigated the acute effect of low-flux hemodialysis (HD) (removal of small molecules) and pre-dilution hemodiafiltration (pre-HDF) (additional removal of larger molecules) on cerebral compartment volumes using quantitative magnetic resonance imaging (MRI) in chronic uremic patients. Twelve patients underwent a session of HD and pre-HDF in a randomized crossover study with equal ultrafiltration. MRI was performed immediately before and after dialysis...
March 23, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28332339/sonographic-and-cytologic-differences-of-niftp-from-infiltrative-or-invasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-a-review-of-179-cases
#18
REVIEW
Grace C H Yang, Karen O Fried, Theresa Scognamiglio
We reclassified 179 cases of the follicular variant (FV) of papillary thyroid carcinoma (PTC) into 72 (40.2%) noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 37 (20.7%) encapsulated FVPTC with invasion (EFVPTC), and 70 (39.1%) infiltrative FVPTC (IFVPTC) without a capsule. In the NIFTP group, 5.6% cytology were hypercellular and the remainder low to moderate cellularity. PTC nuclei were absent in 18%, focally present in 37.5%, and diffusely present in 44.4%. In the EFVPTC group, 8...
March 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28332232/paper-based-colorimetric-sensor-system-for-high-throughput-screening-of-c-h-borylation
#19
Han-Sung Kim, Min Sik Eom, Min Su Han, Sunwoo Lee
A paper-based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B2Pin2) and applied as a high-throughput screening protocol in Ir-catalyzed C-H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue-violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B2Pin2...
March 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28331801/anatomical-brain-difference-of-subthreshold-depression-in-young-and-middle-aged-individuals
#20
Jing Li, Zengjian Wang, JiWon Hwang, Bingcong Zhao, Xinjing Yang, Suicheng Xin, Yu Wang, Huili Jiang, Peng Shi, Ye Zhang, Xu Wang, Courtney Lang, Joel Park, Tuya Bao, Jian Kong
BACKGROUND: Subthreshold depression (StD) is associated with substantial functional impairments due to depressive symptoms that do not fully meet the diagnosis of major depressive disorder (MDD). Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research. AIM: In this study we investigated common volumetric brain changes in both young and middle-aged StD patients. METHODS: Two cohorts of StD patients, young and middle-aged, (n = 57) and matched controls (n = 76) underwent voxel-based morphometry (VBM)...
2017: NeuroImage: Clinical
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