Takahiro Suzuki, Jérémy Chéret, Fernanda S Dinelli, Ali Rajabi-Estarabadi, Aysun Akhundlu, Dana-Lee Demetrius, Jennifer Gherardini, Aviad Keren, Matthew Harries, Jose Rodriguez-Feliz, Gorana Epstein-Kuka, Wendy Lee, Talveen Purba, Amos Gilhar, Ralf Paus
The autoimmunity-promoting cytokine, Interleukin-15 (IL-15), is often claimed to be a key pathogenic cytokine in alopecia areata (AA). Yet, rhIL-15 promotes human hair follicle (HF) growth ex vivo. We have asked whether the expression of IL-15 and its receptor (IL-15R) isoforms is altered in human AA and how IL-15 impacts on human HF immune privilege (HF-IP) in the presence/absence of interferon-γ (IFNγ), the well-documented key AA-pathogenic cytokine, and on hair regrowth after experimental AA induction in vivo...
April 5, 2024: Journal of Autoimmunity