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Hair follicle

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https://www.readbyqxmd.com/read/28723343/%C3%AE-catenin-is-involved-in-oleanolic-acid-dependent-promotion-of-proliferation-in-human-hair-matrix-cells-in-an-in-vitro-organ-culture-model
#1
Ben Liu, Xianyan Chen, Huan Yi, Le Han, Bin Ji, Haiyan Chen, Wenjia Deng, Miaojian Wan
Oleanolic acid (OA), a pentacyclic triterpenoid compound which can be found in >1600 plants, has been shown to promote hair growth. To study the mechanisms of OA on hair growth, we investigated hair follicle (HF) growth on four different concentration OA using human hair follicle organ culture model. We found that HFs treated with 1 or 10μg/mL OA showed statistically enhanced elongation of the hair shaft and anagen-like stage. Moreover, higher positive rate of Ki-67, a matrix cellular marker of proliferation, was detected in the same groups treated with 1 or 10μg/mL than those treated with vehicle...
July 16, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28722457/-diseases-affecting-the-scalp
#2
Dana Suchánková
The skin of the scalp differs from the skin on the other areas of the body because of a higher density of hair follicles and higher sebum production. These, together with the presence of hair, provide a suitable environment for superficial infections, infestations and inflammatory diseases. The good condition of the scalp has a significant impact on the patient's mental well-being and social interaction. The visibility of this part of the skin and the presence of hair itself restrict the range of possible therapeutic agents that can be used due to the complicated application and poor cosmetic outcome...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28722455/-hidradenitis-suppurativa-symptoms-diagnostics-and-therapy
#3
Monika Arenbergerová, Robert Artur Dahmen, Petr Arenberger
Hidradenitis suppurativa is a chronic skin disorder characterized by recurrent inflammatory nodules, fistulas, abscesses, and scarring mainly in the intertriginous areas with terminal hair and apocrine glands. Hidradenitis suppurativa manifests usually after puberty, in the third life decade and persists for many years. The prevalence of the disease is estimated to be 0,5 % in the Czech Republic. Women are most often affected in the axillary and inguinal parts, while men in the perianal and gluteal areas. The exact pathogenesis is still unknown...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28718933/treatment-of-hidradenitis-suppurativa-with-rifampicin-have-we-forgotten-tuberculosis
#4
P Mendes-Bastos, R Macedo, R Duarte
Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin (R+C) has been suggested as a possible treatment regimen (level of evidence III, strength of recommendation C)...
July 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28717940/alopecia-areata-a-comprehensive-review-of-pathogenesis-and-management
#5
REVIEW
Ralph M Trüeb, Maria Fernanda Reis Gavazzoni Dias
Alopecia areata is a common hair loss condition that is characterized by acute onset of non-scarring hair loss in usually sharply defined areas ranging from small patches to extensive or less frequently diffuse involvement. Depending on its acuity and extent, hair loss is an important cause of anxiety and disability. The current understanding is that the condition represents an organ-specific autoimmune disease of the hair follicle with a genetic background. Genome-wide association studies provide evidence for the involvement of both innate and acquired immunity in the pathogenesis, and mechanistic studies in mouse models of alopecia areata have specifically implicated an IFN-γ-driven immune response, including IFNγ, IFNγ-induced chemokines and cytotoxic CD8 T cells as the main drivers of disease pathogenesis...
July 17, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28717319/changes-in-histopathology-and-cytokeratin-ae1-ae3-expression-in-skin-graft-with-different-time-on-indonesian-local-cats
#6
Erwin, Etriwati, Gunanti, Ekowati Handharyani, Deni Noviana
AIM: A good skin graft histopathology is followed by formation of hair follicle, sweat gland, sebaceous gland, blood vessel, lightly dense connective tissue, epidermis, and dermis layer. This research aimed to observe histopathology feature and cytokeratin AE1/AE3 expression on cat skin post skin grafting within a different period of time. MATERIALS AND METHODS: Nine male Indonesian local cats aged 1-2 years old weighing 3-4 kg were separated into three groups. First surgery created defect wound of 2 cm × 2 cm in size to whole groups...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28716435/reference-values-for-skin-microanatomy-a-systematic-review-and-meta-analysis-of-ex%C3%A2-vivo-studies
#7
Haoming Xu, Maira Fonseca, Zachary Wolner, Esther Chung, Xinyuan Wu, Shamir Geller, Stephen W Dusza, Antonio P DeRosa, Ashfaq A Marghoob, Klaus J Busam, Allan C Halpern, Michael A Marchetti
BACKGROUND: Few studies have characterized reference values of normal human skin microanatomy parameters. OBJECTIVE: To quantify histologic measurements of epidermal thickness, melanocyte density, hair follicle density, and eccrine gland density as a function of age and anatomic site. METHOD: We searched the PubMed, Embase, Web of Science, and Cochrane databases for articles published through May 25, 2017. Two reviewers independently screened 2016 articles; 327 relevant articles and 151 additional articles found via forward or reference citations underwent full-text review by 1 of 4 reviewers for relevance, data extraction, and critical appraisal...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28711498/promotion-of-hair-growth-by-newly-synthesized-ceramide-mimetic-compound
#8
Bu-Mahn Park, Soon-Sun Bak, Kyung-Oh Shin, Minhee Kim, Daehwan Kim, Sang-Hun Jung, Sekyoo Jeong, Young Kwan Sung, Hyunjong Kim
Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28708295/cd13-is-a-marker-for-onychofibroblasts-within-nail-matrix-onychodermis-comparison-of-its-expression-patterns-in-the-nail-unit-and-in-the-hair-follicle
#9
Ji-Hye Park, Dong-Youn Lee, Kee-Taek Jang, Sang-Yun Ha, Ghee Young Kwon, Kyung-Hoon Lee, Jong Sup Shim, Eun Ji Kwon
BACKGROUND: We previously demonstrated the presence of onychodermis, a specialized mesenchymal cell population beneath the the nail matrix and proximal nail bed demonstrating CD10 expression. We hypothesize that the onychodermis could be the nail analog of the follicular dermal papilla, which is known to express CD13. We compare CD13 expression patterns between specialized mesenchymes of nail and hair, and compare these findings with CD10 expression patterns. METHODS: CD10 and CD13 immunohistochemisty was performed on polydactyly and adult cadaveric nail units, and on hair follicles in scalp nevus sebaceus excision specimens...
July 14, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28705989/emergent-cellular-self-organization-and-mechanosensation-initiate-follicle-pattern-in-the-avian-skin
#10
Amy E Shyer, Alan R Rodrigues, Grant G Schroeder, Elena Kassianidou, Sanjay Kumar, Richard M Harland
The spacing of hair in mammals and feathers in birds is one of the most apparent morphological features of the skin. This pattern arises when uniform fields of progenitor cells diversify their molecular fate while adopting higher-order structure. Using the nascent skin of the developing chicken embryo as a model system, we find that morphological and molecular symmetries are simultaneously broken by an emergent process of cellular self-organization. The key initiators of heterogeneity are dermal progenitors, which spontaneously aggregate through contractility-driven cellular pulling...
July 13, 2017: Science
https://www.readbyqxmd.com/read/28702144/establishment-of-human-hair-follicle-mesenchymal-stem-cells-with-overexpressed-human-hepatocyte-growth-factor
#11
Dan Zhou, Hongjing Cheng, Jinyu Liu, Lei Zhang
OBJECTIVES: Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. MATERIALS AND METHODS: We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, we verified the property of transfected cells through detecting surface marker by flow cytometry...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28702107/acute-appendicitis-due-to-hair-follicle-obstruction-a-rare-case-report
#12
Samir Abdullazade, Bahattin Bayar, Mehmet Can, Ezgi Altinsoy, Ilker Kiziloglu
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28700594/hierarchical-patterning-modes-orchestrate-hair-follicle-morphogenesis
#13
James D Glover, Kirsty L Wells, Franziska Matthäus, Kevin J Painter, William Ho, Jon Riddell, Jeanette A Johansson, Matthew J Ford, Colin A B Jahoda, Vaclav Klika, Richard L Mort, Denis J Headon
Two theories address the origin of repeating patterns, such as hair follicles, limb digits, and intestinal villi, during development. The Turing reaction-diffusion system posits that interacting diffusible signals produced by static cells first define a prepattern that then induces cell rearrangements to produce an anatomical structure. The second theory, that of mesenchymal self-organisation, proposes that mobile cells can form periodic patterns of cell aggregates directly, without reference to any prepattern...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28699278/regulatory-t-cells-in-skin
#14
REVIEW
Niwa Ali, Michael D Rosenblum
Foxp3+ CD4+ Regulatory T cells (Tregs) are a subset of immune cells that function to regulate tissue inflammation. Skin is one of the largest organs and is home to a large proportion of the body's Tregs. However, relative to other tissues (such as the spleen and gastrointestinal tract) the function of Tregs in skin is less well defined. Here, we review our understanding of how Tregs migrate to skin and the cellular and molecular pathways required for their maintenance in this tissue. In addition, we outline what is known about the specialized functions of Tregs in skin...
July 12, 2017: Immunology
https://www.readbyqxmd.com/read/28697631/recent-advances-on-biomedical-applications-of-scaffolds-in-wound-healing-and-dermal-tissue-engineering
#15
Azizeh Rahmani Del Bakhshayesh, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Mohammad Samiei, Effat Alizadeh, Mohammadreza Alizadeh-Ghodsi, Soodabeh Davaran, Azadeh Montaseri
The tissue engineering field has developed in response to the shortcomings related to the replacement of the tissues lost to disease or trauma: donor tissue rejection, chronic inflammation and donor tissue shortages. The driving force behind the tissue engineering is to avoid the mentioned issues by creating the biological substitutes capable of replacing the damaged tissue. This is done by combining the scaffolds, cells and signals in order to create the living, physiological, three-dimensional tissues. A wide variety of skin substitutes are used in the treatment of full-thickness injuries...
July 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28695824/a-multi-scale-model-for-hair-follicles-reveals-heterogeneous-domains-driving-rapid-spatiotemporal-hair-growth-patterning
#16
Qixuan Wang, Ji Won Oh, Hye-Lim Lee, Anukriti Dhar, Tao Peng, Raul Ramos, Christian Fernando Guerrero-Juarez, Xiaojie Wang, Ran Zhao, Xiaoling Cao, Jonathan Le, Melisa A Fuentes, Shelby C Jocoy, Antoni R Rossi, Brian Vu, Kim Pham, Xiaoyang Wang, Nanda Maya Mali, Jung Min Park, June-Hyug Choi, Hyunsu Lee, Julien Legrand, Eve Kandyba, Jung Chul Kim, Moonkyu Kim, John Foley, Zhengquan Yu, Krzysztof Kobielak, Bogi Andersen, Kiarash Khosrotehrani, Qing Nie, Maksim V Plikus
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns...
July 11, 2017: ELife
https://www.readbyqxmd.com/read/28690776/pilomatrixoma-located-on-the-cruris-an-uncommon-localization
#17
Ismail Burak Atalay, Izzet Korkmaz, Safak Gungor
Pilomatrixoma is a benign tumor of hair follicle matrix cells. The majority of all pilomatrixomas were reported to affect the head-neck region and rarely the upper extremity. We present a case of left-leg pilomatrixoma, which is a extremely rare localization, in a 10-year-old boy.
July 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28690518/trichoscopic-findings-of-erosive-pustular-dermatosis-of-the-scalp-associated-with-gefitinib
#18
Tomohisa Fukui, Hideo Kitamura, Ken Harada, Hajime Nakano, Daisuke Sawamura
Alopecia associated with epidermal growth factor receptor (EGFR) inhibitor therapy is a rare cutaneous side effect with the potential to progress to scarring alopecia. Thus, dermatologists should make an early diagnosis. We present the case of a 57-year-old Japanese female with scarring alopecia associated with gefitinib, which is an EGFR inhibitor, including trichoscopic findings. The patient treated with gefitinib for non-small cell lung cancer experienced skin rash and hair loss of the scalp. The scalp lesions appeared similar to erosive pustular dermatosis of the scalp...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28689433/experimental-and-early-investigational-drugs-for-androgenetic-alopecia
#19
Hongwei Guo, Wendi Victor Gao, Hiromi Endo, Kevin John McElwee
Treatments for androgenetic alopecia constitute a multi-billion-dollar industry, however, currently available therapeutic options have variable efficacy. Consequently, in recent years small biotechnology companies and academic research laboratories have begun to investigate new or improved treatment methods. Research and development approaches include improved formulations and modes of application for current drugs, new drug development, development of cell-based treatments, and medical devices for modulation of hair growth...
July 12, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28689207/design-of-finasteride-loaded-nanoparticles-for-potential-treatment-of-alopecia
#20
Luís V Roque, Inês S Dias, Nuno Cruz, Ana Rebelo, Amílcar Roberto, Patrícia Rijo, Catarina P Reis
BACKGROUND/AIMS: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with poor aqueous solubility, blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT) in a significant reduction in DHT concentration, achieving satisfactory results in alopecia treatment. However, its oral intake generally causes severe side effects. Considering that there is currently no scientifically proven treatment, new drug delivery systems able to improve alopecia therapy are urgently required...
July 8, 2017: Skin Pharmacology and Physiology
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