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Luoman Pu, Shuwen Zhang, Fei Li, Ranghu Wang, Jiuchun Yang, Liping Chang
During the last 40 years, the quantity and spatial patterns of farmland in Western Jilin have changed dramatically, which has had a great impact on soybean production potential. This study used one of the most advanced crop production potential models, the Global Agro-Ecological Zones model, to calculate the soybean production potential in Western Jilin based on meteorological, topography, soil and land use data, and analyzed the impact of farmland change on soybean production potential during 1975⁻2013. The main conclusions were the following: first, the total soybean production potential in Western Jilin in 2013 was 8...
July 18, 2018: International Journal of Environmental Research and Public Health
Yoonjung Kim, Myeongsang Lee, Inchul Baek, Taeyoung Yoon, Sungsoo Na
Spider silk exhibits mechanical properties such as high strength and toughness that are superior to those of any man-made fibre (Bourzac 2015 Nature 519 , S4-S6 (doi:10.1038/519S4a)). This high strength and toughness originates from a combination of the crystalline (exhibiting robust strength) and amorphous (exhibiting superb extensibility) regions present in the silk (Asakura et al 2015 Macromolecules 48 , 2345-2357 (doi:10.1021/acs.macromol.5b00160)). The crystalline regions comprise a mixture of poly-alanine and poly-glycine-alanine...
July 2018: Journal of the Royal Society, Interface
Parag K Thaware, Sonia McKenna, Christopher C Patterson, Claire Casey, David R McCance
Context: Obesity is a global epidemic, and there is a focus on identifying markers of obesity in children with a view to prevention. Objective: We aimed to prospectively examine the association of maternal fasting lipids with adiposity in 5-7-year old offspring in a large observational study. Design: 1612 pregnant women were recruited to the Belfast centre of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study in a large tertiary maternity hospital at an average of 28 weeks gestation...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
M Timmermans, M A van der Aa, R I Lalisang, P O Witteveen, K K Van de Vijver, R F Kruitwagen, G S Sonke
OBJECTIVE: Treatment for advanced epithelial ovarian cancer (EOC) consists of debulking surgery and (neo)adjuvant platinum-based chemotherapy. The aim of this study was to evaluate whether the time from surgery to adjuvant chemotherapy (TTC) was associated with clinical outcome. METHODS: We identified all Dutch patients who received optimal or complete debulking surgery for primary EOC (FIGO IIb-IV) between 2008 and 2015 from the Netherlands Cancer Registry. TTC was divided into three groups based on the interquartile range (IQR)...
July 9, 2018: Gynecologic Oncology
Ehud Herbst, Pedro A Baldera-Aguayo, Hyunwook Lee, Virginia W Cornish
Metabolic engineering stands to transform the discovery and production of a wide range of chemicals, but metabolic engineering currently demands considerable resource investments that restrict commercial application. To facilitate the applicability of metabolic engineering, general high-throughput and readily implemented technologies are needed to assay vast libraries of strains producing desirable chemicals. Toward this end, we describe here the development of a yeast three hybrid (Y3H) assay as a general, high-throughput, versatile and readily implemented approach for the detection of target molecule biosynthesis...
July 24, 2018: Biochemistry
Kristin Cecilie Carlsson Petri, Steen Hvass Ingwersen, Anne Flint, Jeppe Zacho, Rune Viig Overgaard
INTRODUCTION: Semaglutide, a new treatment option approved for the treatment of patients with type 2 diabetes mellitus, is a glucagon-like peptide-1 receptor agonist to be injected subcutaneously once weekly. This analysis used a population pharmacokinetic model of semaglutide to identify clinically relevant covariates for exposure. METHODS: A total of 1612 patients with up to seven pharmacokinetic observations each were included in the analysis. All subjects had type 2 diabetes mellitus and were enrolled in one of five trials in the phase III development program for subcutaneous semaglutide once weekly (the SUSTAIN program)...
August 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Shubham Misra, Pumanshi Talwar, Amit Kumar, Pradeep Kumar, Ram Sagar, Deepti Vibha, Awadh K Pandit, Arti Gulati, Suman Kushwaha, Kameshwar Prasad
BACKGROUND: Ischemic stroke (IS) is a complex and devastating vascular disease that has become one of the leading causes of disability and mortality worldwide. Several studies have shown the association between matrix metalloproteinase (MMP) family gene polymorphisms and IS. However, the results have been indecisive. OBJECTIVE: To investigate the association between Matrix Metalloproteinase gene polymorphisms and risk of IS. METHODS: A literature search for eligible candidate gene studies published before, 28 June 2017, was conducted in the PubMed, EMBASE, Cochrane and Google Scholar databases...
September 25, 2018: Gene
(no author information available yet)
Sandberg L., Rosenberg L., Sandman P.-O. & Borell L. (2017). Risks in situations that are experienced as unfamiliar and confusing - the perspective of persons with dementia. Dementia, 16(4), 471-485. doi: 10.1177/1471301215603836 This article, published in the May 2017 Issue of Dementia, has the following corrections: On page 474, in the last line of the Ethical Consideration heading, the author would like to replace number 2008/1612-32 to 2009/1540-31/2. On page 477, the author would like to correct the below sentence: "The second category shows how the participants in six different ways aspired to handle situations fraught with risk so that nothing undesirable would happen" should have read "The second category shows how the participants in four different ways aspired to handle situations fraught with risk so that nothing undesirable would happen"...
July 2018: Dementia
Shannon L Nowotarski, Boobalan Pachaiyappan, Steven L Holshouser, Craig J Kutz, Youxuan Li, Yi Huang, Shiv K Sharma, Robert A Casero, Patrick M Woster
No abstract text is available yet for this article.
July 23, 2018: Bioorganic & Medicinal Chemistry
Dan G O'Neill, Lauren Baral, David B Church, Dave C Brodbelt, Rowena M A Packer
Background: Despite its Gallic name, the French Bulldog is a breed of both British and French origin that was first recognised by The Kennel Club in 1906. The French Bulldog has demonstrated recent rapid rises in Kennel Club registrations and is now (2017) the second most commonly registered pedigree breed in the UK. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory, neurological and dermatological problems. The VetCompass™ Programme collates de-identified clinical data from primary-care veterinary practices in the UK for epidemiological research...
2018: Canine Genetics and Epidemiology
Aaron C Hinken, Andrew N Billin
Adult skeletal muscle contains a population of resident stem cells known as muscle stem cells (MuSC) or satellite cells. This population of cells is required for regeneration of functional myofibers after damage. Aging reduces the proliferative response of satellite cells post-injury. This deficient response is thought to contribute to slowed recovery of muscle function after damage in the elderly and may also contribute to age-related loss of muscle function (sarcopenia). Numerous techniques are now available for the isolation of highly purified satellite cells from mice and humans (Sherwood, et al...
2018: Methods in Molecular Biology
Zoltán Herold, Viktória Ambrus, Magdolna Herold, György Herczeg, Péter Igaz, László Harsányi, Anikó Somogyi
INTRODUCTION: The relationship between platelets and metastatic tumor cells is an ongoing research area. Pre- and postoperative thrombocytosis are suggested predictive survival markers. Colorectal cancer and type 2 diabetes are characterized by various changes to platelets. The occurrence of colorectal cancer is more frequent in diabetes. AIM: Our aim was to determine the occurrence of type 2 diabetes in colorectal cancer patients, who attended the Semmelweis University 2nd Department of Internal Medicine's Oncology Department in the last three years...
May 2018: Orvosi Hetilap
Essra A Noorwali, Janet E Cade, Victoria J Burley, Laura J Hardie
OBJECTIVES: There is increasing evidence to suggest an association between sleep and diet. The aim of the present study was to examine the association between sleep duration and fruit/vegetable (FV) intakes and their associated biomarkers in UK adults. DESIGN: Cross-sectional. SETTING: Data from The National Diet and Nutrition Survey. PARTICIPANTS: 1612 adults aged 19-65 years were included, pregnant/breastfeeding women were excluded from the analyses...
April 27, 2018: BMJ Open
Elodie Choque, Christophe Klopp, Sophie Valiere, José Raynal, Florence Mathieu
BACKGROUND: Black Aspergilli represent one of the most important fungal resources of primary and secondary metabolites for biotechnological industry. Having several black Aspergilli sequenced genomes should allow targeting the production of certain metabolites with bioactive properties. RESULTS: In this study, we report the draft genome of a black Aspergilli, A. tubingensis G131, isolated from a French Mediterranean vineyard. This 35 Mb genome includes 10,994 predicted genes...
March 15, 2018: BMC Genomics
Manuela Hoedl, Daniela Schoberer, Ruud J G Halfens, Christa Lohrmann
AIMS AND OBJECTIVES: To adapt international guideline recommendations for the conservative management of urinary incontinence (UI), defined as any involuntary loss of urine, in Austrian nursing home residents following the ADAPTE-process. BACKGROUND: Many international guidelines for managing UI are available. Nevertheless, the international recommendations have not yet been adapted to address the Austrian nursing home context. This crucial adaptation process will enhance the acceptance and applicability of the recommendations as well as encourage adherence among Austrian nurses and nursing home residents...
April 27, 2018: Journal of Clinical Nursing
Tobias Hilbert, Paul Markowski, Stilla Frede, Olaf Boehm, Pascal Knuefermann, Georg Baumgarten, Andreas Hoeft, Sven Klaschik
We previously demonstrated that pre-conditioning with CpG oligonucleotide (ODN) 1668 induces quick up-regulation of gene expression 3 hours post-murine myocardial ischaemia/reperfusion (I/R) injury, terminating inflammatory processes that sustain I/R injury. Now, performing comprehensive microarray and biocomputational analyses, we sought to further enlighten the "black box" beyond these first 3 hours. C57BL/6 mice were pretreated with either CpG 1668 or with control ODN 1612, respectively. Sixteen hours later, myocardial ischaemia was induced for 1 hour in a closed-chest model, followed by reperfusion for 24 hours...
July 2018: Journal of Cellular and Molecular Medicine
Kubilay Yıldırım, Adem Yağcı, Seda Sucu, Sümeyye Tunç
Roots are the major interface between the plant and various stress factors in the soil environment. Alteration of root system architecture (RSA) (root length, spread, number and length of lateral roots) in response to environmental changes is known to be an important strategy for plant adaptation and productivity. In light of ongoing climate changes and global warming predictions, the breeding of drought-tolerant grapevine cultivars is becoming a crucial factor for developing a sustainable viticulture. Root-trait modeling of grapevine rootstock for drought stress scenarios, together with high-throughput phenotyping and genotyping techniques, may provide a valuable background for breeding studies in viticulture...
June 2018: Plant Physiology and Biochemistry: PPB
Mangmang Xu, Dan Li, Shihong Zhang
BACKGROUND: Sensory stimulation via acupuncture has been reported to alter activities of numerous neural systems by activating multiple efferent pathways. Acupuncture, one of the main physical therapies in Traditional Chinese Medicine, has been widely used to treat patients with stroke for over hundreds of years. This is the first update of the Cochrane Review originally published in 2005. OBJECTIVES: To assess whether acupuncture could reduce the proportion of people with death or dependency, while improving quality of life, after acute ischemic or hemorrhagic stroke...
March 30, 2018: Cochrane Database of Systematic Reviews
Tingfeng Zhu, Yongjun Hu, Kang Yang, Ning Dong, Meng Yu, Ningjing Jiang
The authors report on a surface-enhanced Raman scattering (SERS) nanoprobe for the specific detection of Escherichia coli O157:H7 (E. coli O157:H7). Gold nanoparticles (AuNPs) were coated with a thick silica shell, and the Raman reporter (4,4'-dipyridyl) was embedded between gold nanoparticle and silica shell. This technique prevents any external effects on the AuNPs from the environment and avoids any interaction between the Raman reporter and possible impurities. Compared to the SERS nanoprobe of the conventional AuNP/AgNP type, the present nanoprobe can be applied in complex biochemical circumstances without aggregation because of its excellent stability...
December 6, 2017: Mikrochimica Acta
Amy L Leber, Kathy Everhart, Judy A Daly, Aubrey Hopper, Amanda Harrington, Paul Schreckenberger, Kathleen McKinley, Matthew Jones, Kristen Holmberg, Bart Kensinger
The FilmArray Respiratory Panel 2 (RP2) is a multiplex in vitro diagnostic test for the simultaneous and rapid (∼45-min) detection of 22 pathogens directly from nasopharyngeal swab (NPS) samples. It contains updated (and in some instances redesigned) assays that improve upon the FilmArray Respiratory Panel (RP; version 1.7), with a faster run time. The organisms identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus, human rhinovirus/enterovirus, influenza virus A, influenza virus A H1, influenza virus A H1-2009, influenza virus A H3, influenza virus B, parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3, parainfluenza virus 4, respiratory syncytial virus, Bordetella pertussis , Chlamydia pneumoniae , and Mycoplasma pneumoniae Two new targets are included in the FilmArray RP2: Middle East respiratory syndrome coronavirus and Bordetella parapertussis This study provides data from a multicenter evaluation of 1,612 prospectively collected NPS samples, with performance compared to that of the FilmArray RP or PCR and sequencing...
June 2018: Journal of Clinical Microbiology
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