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https://www.readbyqxmd.com/read/30332410/construct-validation-of-a-frailty-index-an-hiv-index-and-a-protective-index-from-a-clinical-hiv-database
#1
Iacopo Franconi, Olga Theou, Lindsay Wallace, Andrea Malagoli, Cristina Mussini, Kenneth Rockwood, Giovanni Guaraldi
BACKGROUND: Standard care for HIV clinical practice has started focusing on age-related problems, but despite this recent change physicians involved in HIV care do not often screen HIV patients for frailty. Our aim was to construct three indexes from an HIV clinical database (i.e. Frailty Index, (FI), HIV Index, (HIVI), and Protective Index (PI)) and to assess levels of frailty, HIV severity and demographic and protective lifestyle factors among HIV patients. METHODS AND FINDINGS: We included data from 1612 patients who attended an Italian HIV clinic between September 2016 and December2017 (mean±SD age: 53...
2018: PloS One
https://www.readbyqxmd.com/read/30319704/psychosocial-predictors-of-cognitive-impairment-in-the-elderly-a-cross-sectional-study
#2
Mahbobeh Faramarzi, Maryam Zarin Kamar, Farzan Kheirkhah, Ahmad Karkhah, Ali Bijani, Seyed Reza Hosseini
Objective: Cognitive impairment is a major public health problem among elderly population. The aim of this study was to assess some psychosocial predictors of cognitive impairment (age, education, living alone, smoking, depression and social support) in the Iranian elderly population. Method : A total of 1612 elderly (over 60 years) were enrolled in this cross-sectional study. Cognitive function was assessed using Mini Mental State Examination (MMSE). In addition, data from psychological tests and demographic characteristics were analyzed...
July 2018: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/30318330/intensive-imaging-based-follow-up-of-surgically-treated-localised-renal-cell-carcinoma-does-not-improve-post-recurrence-survival-results-from-a-european-multicentre-database-recur
#3
Saeed Dabestani, Christian Beisland, Grant D Stewart, Karim Bensalah, Eirikur Gudmundsson, Thomas B Lam, William Gietzmann, Paimaun Zakikhani, Lorenzo Marconi, Sergio Fernandéz-Pello, Serenella Monagas, Samuel Paul Williams, Christian Torbrand, Thomas Powles, Erik Van Werkhoven, Richard Meijer, Alessandro Volpe, Michael Staehler, Börje Ljungberg, Axel Bex
The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association with outcome after detection of disease recurrence. Consecutive patients with nonmetastatic RCC (n=1612) treated with curative intent at 12 institutes across eight European countries between 2006 and 2011 were included. Recurrence occurred in 336 patients. Cross-sectional (computed tomography, magnetic resonance imaging) and conventional (chest X-ray, ultrasound) methods were used in 47% and 53%, respectively...
October 11, 2018: European Urology
https://www.readbyqxmd.com/read/30292604/outcomes-and-cost-of-fenestrated-versus-standard-endovascular-repair-of-intact-abdominal-aortic-aneurysm-in-the-united-states
#4
Satinderjit Locham, Muhammad Faateh, Jasninder Dhaliwal, Besma Nejim, Hanaa Dakour-Aridi, Mahmoud B Malas
BACKGROUND: Fenestrated endovascular aneurysm repair (FEVAR) has expanded the indications of this minimally invasive procedure to include patients with pararenal aneurysms. The actual cost of this relatively newer technology compared with standard endovascular aneurysm repair (EVAR) has not been studied before. Thus, the aim of this study was to analyze in-hospital costs and adverse outcomes in patients undergoing FEVAR vs EVAR for intact abdominal aortic aneurysms (AAAs). METHODS: Using the Premier Healthcare Database (2012-2015), we identified all patients who underwent elective EVAR and FEVAR...
October 3, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30272683/sapphire-fiber-bragg-gratings-inscribed-with-a-femtosecond-laser-line-by-line-scanning-technique
#5
Xizhen Xu, Jun He, Changrui Liao, Kaiming Yang, Kuikui Guo, Chi Li, Yunfang Zhang, Zhengbiao Ouyang, Yiping Wang
We propose and demonstrate the fabrication of single-crystal sapphire fiber Bragg gratings (SFBGs) using a femtosecond laser line-by-line scanning technique. This approach provides a robust method for producing SFBGs at various Bragg wavelengths with an acceptable reflectivity. The spectrum characteristics of the SFBGs with various fiber diameters, track lengths, and grating pitch quantities were investigated. An SFBG with a reflectivity of 6.3% was obtained via optimization of fabrication parameters. Additionally, a serial array consisting of five SFBGs at different wavelengths was successfully constructed...
October 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/30218244/drivers-of-cost-for-pancreatic-surgery-it-s-not-about-hospital-volume
#6
Sarah B Bateni, Jennifer L Olson, Jeffrey S Hoch, Robert J Canter, Richard J Bold
BACKGROUND: Outcomes for pancreatic resection have been studied extensively due to the high morbidity and mortality rates, with high-volume centers achieving superior outcomes. Ongoing investigations include healthcare costs, given the national focus on reducing expenditures. Therefore, we sought to evaluate the relationships between pancreatic surgery costs with perioperative outcomes and volume status. METHODS: We performed a retrospective analysis of 27,653 patients who underwent elective pancreatic resections from October 2013 to June 2017 using the Vizient database...
September 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/30122323/decreased-basal-metabolic-rate-can-be-an-objective-marker-for-sarcopenia-and-frailty-in-older-males
#7
Pinar Soysal, Esra Ates Bulut, Idil Yavuz, Ahmet Turan Isik
OBJECTIVES: The aim of this study is to demonstrate the ability of the basal metabolic rate (BMR) to detect frailty and sarcopenia in older males. SETTING AND PARTICIPANTS: A total of 305 male patients undergoing comprehensive geriatric assessment were included in the study. MEASURES: The frailty status was assessed with the Fried criteria. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People criteria...
August 16, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/30022018/impact-of-farmland-change-on-soybean-production-potential-in-recent-40-years-a-case-study-in-western-jilin-china
#8
Luoman Pu, Shuwen Zhang, Fei Li, Ranghu Wang, Jiuchun Yang, Liping Chang
During the last 40 years, the quantity and spatial patterns of farmland in Western Jilin have changed dramatically, which has had a great impact on soybean production potential. This study used one of the most advanced crop production potential models, the Global Agro-Ecological Zones model, to calculate the soybean production potential in Western Jilin based on meteorological, topography, soil and land use data, and analyzed the impact of farmland change on soybean production potential during 1975⁻2013. The main conclusions were the following: first, the total soybean production potential in Western Jilin in 2013 was 8...
July 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30021926/mechanically-inferior-constituents-in-spider-silk-result-in-mechanically-superior-fibres-by-adaptation-to-harsh-hydration-conditions-a-molecular-dynamics-study
#9
Yoonjung Kim, Myeongsang Lee, Inchul Baek, Taeyoung Yoon, Sungsoo Na
Spider silk exhibits mechanical properties such as high strength and toughness that are superior to those of any man-made fibre (Bourzac 2015 Nature 519 , S4-S6 (doi:10.1038/519S4a)). This high strength and toughness originates from a combination of the crystalline (exhibiting robust strength) and amorphous (exhibiting superb extensibility) regions present in the silk (Asakura et al 2015 Macromolecules 48 , 2345-2357 (doi:10.1021/acs.macromol.5b00160)). The crystalline regions comprise a mixture of poly-alanine and poly-glycine-alanine...
July 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/30020528/maternal-lipids-at-28-weeks-gestation-and-offspring-adiposity-at-age-5-to-7-years
#10
Parag K Thaware, Sonia McKenna, Christopher C Patterson, Claire Casey, David R McCance
Context: Obesity is a global epidemic, and there is a focus on identifying markers of obesity in children with a view to prevention. Objective: We aimed to examine prospectively the association of maternal fasting lipids with adiposity in 5- to 7-year-old offspring in a large observational study. Design: Pregnant women (1612) were recruited to the Belfast center of the Hyperglycemia and Adverse Pregnancy Outcome study in a large tertiary maternity hospital at an average of 28 weeks' gestation...
October 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30001834/interval-between-debulking-surgery-and-adjuvant-chemotherapy-is-associated-with-overall-survival-in-patients-with-advanced-ovarian-cancer
#11
M Timmermans, M A van der Aa, R I Lalisang, P O Witteveen, K K Van de Vijver, R F Kruitwagen, G S Sonke
OBJECTIVE: Treatment for advanced epithelial ovarian cancer (EOC) consists of debulking surgery and (neo)adjuvant platinum-based chemotherapy. The aim of this study was to evaluate whether the time from surgery to adjuvant chemotherapy (TTC) was associated with clinical outcome. METHODS: We identified all Dutch patients who received optimal or complete debulking surgery for primary EOC (FIGO IIb-IV) between 2008 and 2015 from the Netherlands Cancer Registry. TTC was divided into three groups based on the interquartile range (IQR)...
September 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29956923/a-yeast-three-hybrid-assay-for-metabolic-engineering-of-tetracycline-derivatives
#12
Ehud Herbst, Pedro A Baldera-Aguayo, Hyunwook Lee, Virginia W Cornish
Metabolic engineering stands to transform the discovery and production of a wide range of chemicals, but metabolic engineering currently demands considerable resource investments that restrict commercial application. To facilitate the applicability of metabolic engineering, general high-throughput and readily implemented technologies are needed to assay vast libraries of strains producing desirable chemicals. Toward this end, we describe here the development of a yeast three hybrid (Y3H) assay as a general, high-throughput, versatile and readily implemented approach for the detection of target molecule biosynthesis...
August 7, 2018: Biochemistry
https://www.readbyqxmd.com/read/29907893/semaglutide-s-c-once-weekly-in-type-2-diabetes-a-population-pharmacokinetic-analysis
#13
Kristin Cecilie Carlsson Petri, Steen Hvass Ingwersen, Anne Flint, Jeppe Zacho, Rune Viig Overgaard
INTRODUCTION: Semaglutide, a new treatment option approved for the treatment of patients with type 2 diabetes mellitus, is a glucagon-like peptide-1 receptor agonist to be injected subcutaneously once weekly. This analysis used a population pharmacokinetic model of semaglutide to identify clinically relevant covariates for exposure. METHODS: A total of 1612 patients with up to seven pharmacokinetic observations each were included in the analysis. All subjects had type 2 diabetes mellitus and were enrolled in one of five trials in the phase III development program for subcutaneous semaglutide once weekly (the SUSTAIN program)...
August 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29906531/association-between-matrix-metalloproteinase-family-gene-polymorphisms-and-risk-of-ischemic-stroke-a-systematic-review-and-meta-analysis-of-29-studies
#14
REVIEW
Shubham Misra, Pumanshi Talwar, Amit Kumar, Pradeep Kumar, Ram Sagar, Deepti Vibha, Awadh K Pandit, Arti Gulati, Suman Kushwaha, Kameshwar Prasad
BACKGROUND: Ischemic stroke (IS) is a complex and devastating vascular disease that has become one of the leading causes of disability and mortality worldwide. Several studies have shown the association between matrix metalloproteinase (MMP) family gene polymorphisms and IS. However, the results have been indecisive. OBJECTIVE: To investigate the association between Matrix Metalloproteinase gene polymorphisms and risk of IS. METHODS: A literature search for eligible candidate gene studies published before, 28 June 2017, was conducted in the PubMed, EMBASE, Cochrane and Google Scholar databases...
September 25, 2018: Gene
https://www.readbyqxmd.com/read/29886776/corrigendum
#15
(no author information available yet)
Sandberg L., Rosenberg L., Sandman P.-O. & Borell L. (2017). Risks in situations that are experienced as unfamiliar and confusing - the perspective of persons with dementia. Dementia, 16(4), 471-485. doi: 10.1177/1471301215603836 This article, published in the May 2017 Issue of Dementia, has the following corrections: On page 474, in the last line of the Ethical Consideration heading, the author would like to replace number 2008/1612-32 to 2009/1540-31/2. On page 477, the author would like to correct the below sentence: "The second category shows how the participants in six different ways aspired to handle situations fraught with risk so that nothing undesirable would happen" should have read "The second category shows how the participants in four different ways aspired to handle situations fraught with risk so that nothing undesirable would happen"...
July 2018: Dementia
https://www.readbyqxmd.com/read/29859749/corrigendum-to-structure-activity-study-for-bis-ureidopropyl-and-bis-thioureidopropyldiamine-lsd1-inhibitors-with-3-5-3-and-3-6-3-carbon-backbone-architectures-bioorg-med-chem-23-2015-1601-1612
#16
Shannon L Nowotarski, Boobalan Pachaiyappan, Steven L Holshouser, Craig J Kutz, Youxuan Li, Yi Huang, Shiv K Sharma, Robert A Casero, Patrick M Woster
No abstract text is available yet for this article.
July 23, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29750111/demography-and-disorders-of-the-french-bulldog-population-under-primary-veterinary-care-in-the-uk-in-2013
#17
Dan G O'Neill, Lauren Baral, David B Church, Dave C Brodbelt, Rowena M A Packer
Background: Despite its Gallic name, the French Bulldog is a breed of both British and French origin that was first recognised by The Kennel Club in 1906. The French Bulldog has demonstrated recent rapid rises in Kennel Club registrations and is now (2017) the second most commonly registered pedigree breed in the UK. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory, neurological and dermatological problems. The VetCompass™ Programme collates de-identified clinical data from primary-care veterinary practices in the UK for epidemiological research...
2018: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/29736711/isolation-of-skeletal-muscle-stem-cells-for-phenotypic-screens-for-modulators-of-proliferation
#18
Aaron C Hinken, Andrew N Billin
Adult skeletal muscle contains a population of resident stem cells known as muscle stem cells (MuSC) or satellite cells. This population of cells is required for regeneration of functional myofibers after damage. Aging reduces the proliferative response of satellite cells post-injury. This deficient response is thought to contribute to slowed recovery of muscle function after damage in the elderly and may also contribute to age-related loss of muscle function (sarcopenia). Numerous techniques are now available for the isolation of highly purified satellite cells from mice and humans (Sherwood, et al...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29730943/-the-occurrence-and-impact-on-survival-of-type-2-diabetes-mellitus-and-thrombocytosis-in-colorectal-cancer-before-and-after-the-surgical-resection-of-the-primary-tumor
#19
Zoltán Herold, Viktória Ambrus, Magdolna Herold, György Herczeg, Péter Igaz, László Harsányi, Anikó Somogyi
INTRODUCTION: The relationship between platelets and metastatic tumor cells is an ongoing research area. Pre- and postoperative thrombocytosis are suggested predictive survival markers. Colorectal cancer and type 2 diabetes are characterized by various changes to platelets. The occurrence of colorectal cancer is more frequent in diabetes. AIM: Our aim was to determine the occurrence of type 2 diabetes in colorectal cancer patients, who attended the Semmelweis University 2nd Department of Internal Medicine's Oncology Department in the last three years...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29703857/the-relationship-between-sleep-duration-and-fruit-vegetable-intakes-in-uk-adults-a-cross-sectional-study-from-the-national-diet-and-nutrition-survey
#20
Essra A Noorwali, Janet E Cade, Victoria J Burley, Laura J Hardie
OBJECTIVES: There is increasing evidence to suggest an association between sleep and diet. The aim of the present study was to examine the association between sleep duration and fruit/vegetable (FV) intakes and their associated biomarkers in UK adults. DESIGN: Cross-sectional. SETTING: Data from The National Diet and Nutrition Survey. PARTICIPANTS: 1612 adults aged 19-65 years were included, pregnant/breastfeeding women were excluded from the analyses...
April 27, 2018: BMJ Open
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