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https://www.readbyqxmd.com/read/29912047/long-term-outcomes-and-risk-factors-after-adult-living-donor-liver-transplantation
#1
Daisuke Imai, Tomoharu Yoshizumi, Kazuhito Sakata, Toru Ikegami, Shinji Itoh, Noboru Harada, Takashi Motomura, Takeo Toshima, Yohei Mano, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Although risk factors for the long-term mortality of liver transplantation are well described, there is a lack of detailed study regarding these factors for adult living donor liver transplantation (LDLT). METHODS: We retrospectively analyzed 528 adult LDLT recipients in our hospital. The risk factors were analyzed for overall deaths >5 years post-LDLT. RESULTS: Over the 20-year follow-up, 137 patients died. Patient survival at 1, 3, 5, and 10 years post-LDLT was 87...
June 13, 2018: Transplantation
https://www.readbyqxmd.com/read/29911962/evans-syndrome-after-successful-immunosuppressant-free-living-donor-liver-transplant
#2
Amr Badawy, Toshimi Kaido, Yoshizawa Atsushi, Shintaro Yagi, Koichiro Hata, Naoko Kamo, Ken Fukumitsu, Hideaki Okajima, Shinji Uemoto
Evans syndrome is an uncommon disease characterized by a combination of autoimmune hemolytic anemia and autoimmune thrombocytopenia concomitantly or sequentially with a positive direct Coombs test in the absence of any underlying known cause. Here, we present a case of an adult patient who underwent living-donor liver transplant that was preceded by bone marrow transplant 20 years earlier from the same HLA identical donor and who received a single-agent immunosuppressive therapy for only 2 months as prophylaxis against graft-versus-host disease...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29902957/is-muscle-meld-a-more-promising-predictor-for-mortality-after-living-donor-liver-transplantation
#3
Amr Badawy, Toshimi Kaido, Yuhei Hamaguchi, Takayuki Anazawa, Shintaro Yagi, Ken Fukumitsu, Naoko Kamo, Hideaki Okajima, Shinji Uemoto
BACKGROUND: To improve the outcome of living donor liver transplantation (LDLT), a scoring system that could predict accurately the patient and graft survival posttransplant is necessary. The aim of this study is to evaluate our previously proposed Muscle-model for end-stage liver disease (M-MELD) score and to compare it with the other available scores to find the best system that correlates with postoperative outcome after liver transplant. METHODS: We retrospectively reviewed the data of 199 patients who underwent LDLT from January 2010 to July 2016 and calculated the preoperative MELD, MELD Na, the product of donor age and MELD (D-MELD), M-MELD, integrated MELD, and the balance of risk (BAR) score in all patients...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29896575/sclerosing-encapsulating-peritonitis-after-living-donor-liver-transplantation-a-case-series-kyoto-experience
#4
Vusal Aliyev, Shintaro Yagi, Ahmed Hammad, Amr Badawy, Yudai Sasaki, Yuki Masano, Gen Yamamoto, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
Sclerosing encapsulating peritonitis (SEP), or abdominal cocoon is a rare cause of intestinal obstruction, and still etiology remains unknown. We report a series of 4 patients with abdominal cocoon, and all the 4 patients had previously undergone living-donor liver transplantation (LDLT). There was no evidence of SEP before and during LDLT. At the time of diagnosis of SEP, 3 out of 4 patients had ascites. First and fourth patients had multiple episodes or attacks of cholangitis, which were managed by percutaneous transhepatic biliary drainage and hepaticojejunostomy, respectively...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29896574/management-of-very-late-peritoneal-metastasis-of-hepatocellular-carcinoma-10-years-after-liver-transplantation-lessons-from-two-cases
#5
Abdulwahab A Alshahrani, Shin Hwang, Gi-Won Song, Deok-Bog Moon, Dong-Hwan Jung, Chul-Soo Ahn, Ki-Hun Kim, Tae-Yong Ha, Gil-Chun Park, Su-Min Ha, Yo-Han Park, Sung-Gyu Lee
Recurrence of hepatocellular carcinoma (HCC) 10 years after liver transplantation (LT) is very rare. Here, we present two cases of peritoneal metastasis of HCC that occurred 10 and 12 years after LT. A 77-year-old male who had undergone deceased-donor LT 10 years earlier showed slow progressive elevation of tumor marker levels over 6 months. Close observation with frequent imaging studies and monthly tumor marker analyses revealed a solitary peritoneal seeding mass. Imaging studies revealed that the mass was highly likely to be metastatic HCC...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29894414/risk-factors-and-clinical-course-for-liver-steatosis-or-nonalcoholic-steatohepatitis-after-living-donor-liver-transplantation
#6
Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Hidetaka Shibata, Ryu Sasaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi, Kazuhiko Nakao
BACKGROUND: Posttransplant liver steatosis occurs frequently and can affect patient outcome. Our aim was to clarify the risk factors for steatosis or steatohepatitis after living donor liver transplantation (LT) through a retrospective examination of recent 100 living donor LT recipients and their liver donors. METHODS: Liver biopsy was performed at 1-year after LT and each year, thereafter, or as needed due to abnormal liver enzyme levels, with a median follow-up of 4 (2~10) years...
June 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29893464/lymphocyte-to-monocyte-ratio-is-a-predictor-of-survival-after-liver-transplantation-for-hepatocellular-carcinoma
#7
Yohei Mano, Tomoharu Yoshizumi, Kyohei Yugawa, Masafumi Ohira, Takashi Motomura, Takeo Toshima, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of the lymphocyte-to-monocytes ratio (LMR) in patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). METHODS: We retrospectively analyzed the records of 216 patients who underwent LDLT for HCC. Patients were divided into high- (n = 126) and low- (n = 90) LMR groups...
June 12, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29892176/living-donor-liver-transplantation-for-acute-on-chronic-liver-failure-based-on-easl-clif-diagnostic-criteria
#8
Abu Bakar H Bhatti, Faisal S Dar, Muhammad O Butt, Eraj Sahaab, Mohammad Salih, Najmul H Shah, Nusrat Y Khan, Haseeb H Zia, Eitzaz U Khan, Nasir A Khan
Background: The European association for the study of the liver and chronic liver failure consortium (EASL-CLIF) recently proposed diagnostic criteria for acute on chronic liver failure (ACLF). There is lack of data regarding liver transplant outcomes in ACLF patients based on these criteria. The objective of this study was to determine outcome following living donor liver transplantation (LDLT) in ACLF patients. Methods: We retrospectively reviewed patients who underwent LDLT for ACLF based on European association for the study of the liver and chronic liver failure consortium (EASL-CLIF) diagnostic criteria (group 1) ( N  = 60) and compared them with ACLF patients who did not undergo transplantation (group 2) ( N  = 59)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892175/outcome-of-living-donor-liver-transplantation-for-wilson-s-disease-in-adults-a-single-center-experience
#9
Narendra S Choudhary, Sanjiv Saigal, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Srinivasan Thiagrajan, Dheeraj Gautam, Deepak Govil, Vijay Vohra, Arvinder S Soin
Introduction: Although liver transplantation is a definitive cure for Wilson's disease (WD), there is limited data about results of living donor liver transplantation (LDLT) in adults. Material and methods: 18 adults underwent LDLT for WD. The presentations before LDLT were decompensated cirrhosis ( n  = 16), acute on chronic liver failure ( n  = 1) and acute liver failure ( n  = 1). The donors were parents ( n  = 2), siblings ( n  = 3), cousin ( n  = 1), daughter ( n  = 1), nephew ( n  = 1), spouse or relatives of spouse ( n  = 9) and from swap transplantation ( n  = 1)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892174/living-donor-liver-transplantation-using-small-for-size-grafts-does-size-really-matter
#10
Pulkit Sethi, Manoj Thillai, Binoj Sivasankarapillai Thankamonyamma, Shweta Mallick, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Sudhindran Surendran, Puneet Dhar, Sudheer Othiyil Vayoth
Background: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR) > 0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR < 0.8) versus normal-sized grafts (GRWR > 0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892173/efficacy-and-safety-of-sofosbuvir-based-regimens-for-treatment-of-hepatitis-c-recurrence-after-living-donor-liver-transplantation-an-experience-from-india
#11
Narendra S Choudhary, Sanjiv Saigal, Dheeraj Gautam, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Arvinder S Soin
Introduction: Results of Sofosbuvir based regimens for hepatitis C (HCV) recurrence after liver transplantation are available from well-designed clinical trials. Most of the data is from deceased donor liver transplant (DDLT) setting, and data on "real world" experience for HCV recurrence after living donor liver transplantation (LDLT) is limited. Material and methods: Consecutive 78 patients who completed Sofosbuvir based HCV treatment after liver transplantation were included...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29889497/acid-promoted-d-a-d-type-far-red-fluorescent-probe-with-high-photostability-for-lysosomal-nitric-oxide-imaging
#12
Fengyang Wang, Shujuan Yu, Zhiai Xu, Lingling Li, Yijing Dang, Xiaowei Xu, Yi Luo, Zhen Cheng, Haijun Yu, Wen Zhang, Ao Zhang, Chunyong Ding
To accurately monitor the variations of lysosomal nitric oxide (NO) under physiological condition remains a great challenge for understanding the biological function of NO. Herein, we developed a new chemotype probe, namely, MBTD, for acid-promoted and far-red fluorescence imaging of lysosomal NO in vitro and ex vivo. MBTD was rationally designed by incorporating o-phenylenediamino (OPD) moiety into the donor-acceptor-donor (D-A-D) type fluorophore based on a dual intramolecular charge transfer (ICT) mechanism...
June 11, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29882487/expression-signature-of-lysosomal-associated-transmembrane-protein-4b-in-hepatitis-c-virus-induced-hepatocellular-carcinoma
#13
Gaurav Roy, Papai Roy, Atanu Bhattacharjee, Mudassar Shahid, Mohammad Misbah, Subash Gupta, Mohammad Husain
INTRODUCTION: Hepatocellular carcinoma is a lethal disease worldwide and therefore the establishment of novel diagnostic biomarkers is imperative. In this study, it was hypothesized that an abnormal expression of the lysosomal-associated protein transmembrane 4 beta ( LAPTM4B) gene is crucial in the pathogenesis of hepatitis C virus-mediated hepatocellular carcinoma; hence we investigated the expression profile of LAPTM4B in hepatitis C virus-induced hepatocellular carcinoma. METHODS: A group of 189 consecutive patients (hepatitis C virus-related hepatocellular carcinoma as tumor cases; n=93, hepatitis C virus-related cirrhotics as disease controls; n=96) opting for living donor liver transplantation as a therapeutic surgical regimen were recruited with informed consent...
May 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29882099/the-impact-of-preoperative-hemoglobin-level-on-the-short-term-outcomes-after-living-donor-liver-transplantation
#14
Amr Badawy, Toshimi Kaido, Ahmed Hammad, Shintaro Yagi, Naoko Kamo, Atsushi Yoshizawa, Hideaki Okajima, Shinji Uemoto
BACKGROUND: Preoperative anemia was reportedly associated with increased morbidity and mortality after various types of surgeries. However, its impact on the outcomes after liver transplantation has not been thoroughly investigated. METHODS: We retrospectively investigated the clinical outcome of 216 consecutive adult patients who underwent living donor liver transplantation at our institute between January 2010 and June 2017 and stratified them according to the hemoglobin level before transplant...
June 7, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29880370/endovascular-treatment-for-very-early-hepatic-artery-stenosis-following-living-donor-liver-transplantation-report-of-two-cases
#15
Y Goto, N Shirahama, S Sasaki, R Kawahara, H Sakai, H Ishikawa, T Hisaka, T Ogata, M Yasunaga, Y Akagi, H Tanaka, K Okuda
BACKGROUND: Some literature has reported on endovascular treatment for very early hepatic artery stenosis (HAS; within 2 weeks after liver transplantation, and has deemed endovascular treatment to be a contraindication because out of serious complications associated with the procedure. We report on 2 cases of very early HAS successfully treated with endovascular treatment after living-donor liver transplantation (LDLT). CASE 1: A 54-year-old woman underwent LDLT with a left liver graft...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880362/living-donor-liver-transplantation-in-hepatitis-c-virus-era-a-report-of-500-consecutive-cases-in-a-single-center
#16
M A Wahab, A Shehta, M Elshoubary, A M Yassen, M Elmorshedi, T Salah, A M Sultan, O Fathy, W R Elsarraf, U Shiha, K Zalata, A N Elghawalby, M Eldesoky, A Monier, R Said, A M Elsabagh, M Ali, A Kandeel, U Abdalla, M Aboelella, M Elsadany, E E Abdel-Khalek, A Marwan, F M ElMorsi, R Adly
BACKGROUND: Living donor liver transplantation (LDLT) is considered a safe alternative to deceased donor liver transplantation (DDLT). In Egypt, DDLT program is still awaited, making LDLT the only hope for patients with end-stage liver disease, mainly due to chronic hepatitis C virus (HCV) infection. The current study is conducted to evaluate our experience of LDLT and discuss the lessons learned from 500 consecutive cases in HCV area. METHODS: We reviewed the data of patients who underwent LDLT at Gastrointestinal Surgery Center, Mansoura University during the period between May 2004 and March 2017...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880361/role-of-adult-living-donor-liver-transplantation-in-the-treatment-of-hepatocellular-carcinoma-within-and-beyond-milan-criteria-a-comparative-study
#17
M C Pavel, S Sanchez Cabus, G Crespo, J Ferrer, C Fondevila, J Fuster, J C Garcia-Valdecasas
BACKGROUND AND AIMS: In the context of the shortage of donors, adult living donor liver transplantation (aLDLT) represents a feasible alternative for patients within as well as beyond the Milan criteria. METHODS: From 2001, we performed 42 aLDLTs for hepatocellular carcinoma (HCC). Sixteen of the recipients were within the Milan criteria, whereas 26 fulfilled the Barcelona-Clinic Liver Cancer Group (BCLC) expanded criteria (1 tumor ≤7 cm, 5 tumors ≤3 cm, or tumors 3 ≤5 cm without macrovascular invasion or down-staging to Milan after loco-regional therapies)...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880360/minimizing-hepatic-artery-thrombosis-and-establishing-safety-of-grafts-with-dual-arteries-in-living-donor-liver-transplantation
#18
N N Mehta, V Mangla, V Varma, S Lalwani, S Mehrotra, D Chawla, S Nundy
BACKGROUND: Hepatic artery thrombosis (HAT) is a dreaded complication following living donor liver transplantation (LDLT) and can lead to graft failure and biliary complications. We evaluated the results of our arterial anastomotic technique and outcomes in grafts with dual arterial supply. PATIENTS AND METHODS: Between July 2010 and June 2015, 225 patients underwent LDLT. The hepatic artery anastomosis was done using our "W technique". In grafts with a dual arterial supply, two anastomoses were performed unless there was significant pulsatile back-bleeding in the smaller artery after the larger anastomosis...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880358/comparison-of-perioperative-renal-function-between-epidural-and-intravenous-patient-controlled-analgesia-after-living-donor-hepatectomy-a-retrospective-study
#19
S Y Ham, E J Kim, T H Kim, B-N Koo
BACKGROUND: Sympathetic blockade associated with epidural analgesia was reported to be a risk factor for acute kidney injury (AKI) following liver resection. The purpose of this study was to compare the incidence of AKI after living-donor hepatectomies according to the type of patient-controlled analgesia (PCA). METHODS: A total of 316 patients after living-donor hepatectomy were retrospectively analyzed; 148 patients in the epidural PCA group and 168 patients in the intravenous (IV) PCA group were evaluated...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29869918/doppler-ultrasound-follow-up-of-middle-hepatic-vein-tributaries-interposition-vessel-graft-in-recipients-of-living-donor-liver-transplantation-using-modified-right-lobe-grafts
#20
Sunyoung Lee, Kyoung Won Kim, So Yeong Jeong, Kyung Jin Lee, So Yeon Kim, Gi Won Song, Sung Gyu Lee
OBJECTIVES: To investigate the value of Doppler ultrasound (US) in recipients of living donor liver transplantation (LDLT) using modified right-lobe grafts (mRLGs) with obstruction of the middle hepatic vein tributaries (MHVTs)-interposition vessel graft (IVG). METHODS: This study included 240 consecutive LDLT recipients in whom 564 MHVTs (>5 mm) were reconstructed using IVG. Regular follow-up Doppler US was performed to assess the patency of the MHVTs-IVG and, if there was an obstruction, to evaluate for the establishment of collateral drainage...
June 5, 2018: British Journal of Radiology
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