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Living Donor Liver

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https://www.readbyqxmd.com/read/29238704/laparoscopy-assisted-versus-open-hepatectomy-for-live-liver-donor-systematic-review-and-meta-analysis
#1
REVIEW
Bin Zhang, Yu Pan, Ke Chen, Hendi Maher, Ming-Yu Chen, He-Pan Zhu, Yi-Bin Zhu, Yi Dai, Jiang Chen, Xiu-Jun Cai
Objective: To assess the feasibility, safety, and potential benefits of laparoscopy-assisted living donor hepatectomy (LADH) in comparison with open living donor hepatectomy (ODH) for liver transplantation. Background: LADH is becoming increasingly common for living donor liver transplant around the world. We aim to determine the efficacy of LADH and compare it with ODH. Methods: A systematic search on PubMed, Embase, Cochrane Library, and Web of Science was conducted in May 2017...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29237235/efficacy-and-safety-of-everolimus-with-reduced-tacrolimus-in-living-donor-liver-transplant-recipients-12-month-results-of-a-randomized-multicenter-study
#2
Long-Bin Jeng, Sung Gyu Lee, Arvinder Singh Soin, Wei-Chen Lee, Kyung-Suk Suh, Dong Jin Joo, Shinji Uemoto, Jaewon Joh, Tomoharu Yoshizumi, Horng-Ren Yang, Gi-Won Song, Patricia Lopez, Jossy Kochuparampil, Carole Sips, Shuhei Kaneko, Gary Levy
In a multicenter, open-label, study, 284 living-donor liver transplant patients were randomized at 30±5 days post-transplant to start everolimus+reduced tacrolimus (EVR+rTAC) or continue standard tacrolimus (TAC Control). EVR+rTAC was non-inferior to TAC Control for the primary efficacy endpoint of treated BPAR, graft loss or death at 12 months post-transplant: difference -0.7% [90%CI -5.2%, 3.7%]; p<0.001 for non-inferiority. tBPAR occurred in 2.2% and 3.6% of patients, respectively. The key secondary endpoint, change in estimated GFR from randomization to month 12, achieved non-inferiority (p<0...
December 13, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29235221/liver-transplant-for-metastatic-pancreatoblastoma-7-year-event-free-survival-after-chemotherapy-pancreatectomy-complete-hepatectomy-and-liver-transplant
#3
A A Ghaffarian, L Book, R L Meyers
Pancreatoblastoma is a rare malignant tumor in children. Surgical resection of the tumor is necessary for cure; however, due to its aggressive nature, it is often unresectable at presentation due to tumor size, local invasion, and/or metastasis. Because it is a rare tumor, there is currently no standard treatment regimen. We report a case of a 4-year-old boy who presented with metastatic pancreatoblastoma with multiple large metastases involving all four sectors of the liver. We began treatment with chemotherapy (cisplatin, 5FU, vincristine, and doxorubicin), which significantly reduced the tumor burden in both the pancreas and liver...
December 13, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29235211/pre-transplant-serum-procalcitonin-level-for-prediction-of-early-post-transplant-sepsis-in-living-donor-liver-transplantation
#4
Takanobu Hara, Akihiko Soyama, Masaaki Hidaka, Koji Natsuda, Tomohiko Adachi, Shinichiro Ono, Satomi Okada, Takashi Hamada, Mitsuhisa Takatsuki, Susumu Eguchi
AIM: Infections are frequent causes of in-hospital mortality after liver transplantation (LT). Elimination of possible risks in the pre-transplant period, early diagnosis of post-transplant sepsis, and prompt administration of antimicrobial agents are important. The objectives of this study were to analyze the impact of early post-transplant sepsis on outcomes and to clarify the value of predictive factors for early post-transplant sepsis. METHODS: The study included 136 patients who underwent initial living donor LT (LDLT) at our institute from April 2009 to December 2016...
December 13, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29234204/middle-hepatic-vein-bleed-during-donor-hepatectomy-technique-for-safe-practice
#5
Madhusudhanan Jegadeesan, Neerav Goyal, Subash Gupta
Safe performance of donor hepatectomy is crucial for sustainability of a living donor liver transplantation (LDLT) program. Middle hepatic vein (MHV) is always encountered during parenchymal transection irrespective of right or left donor hepatectomies. Here we present a safe and effective technique for tackling MHV bleed during LDLT from a single centre experience.
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29232254/orthotropic-live-transplantation-for-cirrhosis-from-hepatitis-c-virus-leads-to-correction-of-factor-ix-deficiency-allowing-for-ankle-arthroplasty-without-factor-replacement-in-a-patient-with-moderate-haemophilia-b
#6
Kumiko Ono, Jun Hirose, Song H Chang, Minoru Kubota, Junya Kinkawa, Megumi Noguchi, Hideyuki Takedani
: Liver transplantation is one of the treatments for haemophilic patients having severe liver cirrhosis who are infected with the hepatitis C virus. Patients with haemophilia can develop arthroplasty requiring surgical intervention, and the surgical outcomes of patients undergoing such procedures after liver transplant has not been reported. Treatment for arthropathy is important for improving the quality of life for patients who survive after liver transplantation. We report the first case of ankle arthroscopic arthrodesis in a patient with haemophilia B after undergoing living donor liver transplantation...
December 11, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29229480/liver-transplantation-for-deterioration-in-native-liver-function-after-portoenterostomy-for-biliary-atresia-in-japan-short-versus-long-term-survivors
#7
Takanori Ochi, Hiroki Nakamura, Momoko Wada, Tsuyoshi Tamura, Hiroyuki Koga, Tadaharu Okazaki, Masahiko Urao, Yoichi Ishizaki, Seiji Kawasaki, Mureo Kasahara, Koichi Mizuta, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: We reviewed our post-Kasai portoenterostomy biliary atresia (BA) patients who required liver transplantation (LTx) for deterioration in native liver (NL) function to investigate mortality in relation to age at LTx. METHODS: BA patients indicated for LTx when less than 18years old (U18; n=17) and when 18 or older (18+; n=13) were compared. All achieved jaundice clearance postoperatively (TBil ≤1.2mg/dL (≈20μmol/L)). RESULTS: In U18, living-donor (LD) LTxs were performed at a median of 6...
November 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29226766/a-case-report-of-living-donor-liver-transplantation-for-fulminant-hepatitis-related-to-hepatitis-e-virus-infection
#8
Keita Shimata, Yasuhiko Sugawara, Hidekazu Yamamoto, Hiroaki Okamoto, Koushi Uchida, Seiichi Kawabata, Kaori Isono, Shintaro Hayashida, Yukihiro Inomata
Hepatitis E virus (HEV) infection which may become fulminant, especially in elderly people is more common than previously recognized in develop countries. Here we report successful living-donor liver transplantation (LDLT) in a case of acute liver failure due to HEV. A 63-year-old Japanese man with no previous history of liver disease was admitted for severe acute hepatitis. Detection of anti-HEV immunoglobulin A established a diagnosis of this virus-related liver failure. The patient suffered from hepatic encephalopathy 10 days after symptom onset and underwent LDLT...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29223705/functional-hepatocyte-clusters-on-bioactive-blend-silk-matrices-towards-generating-bioartificial-liver-constructs
#9
Guru Janani, Samit K Nandi, Biman B Mandal
The creation of in vitro functional hepatic tissue simulating micro-environmental niche of native liver is a keen area of research due to its demand in bioartificial liver (BAL) and cell-based tissue engineering. Here, we investigated the potential of novel blend (BA) silk scaffold fabricated by blending mulberry (Bombyx mori, BM) silk fibroin with cell adhesion motif (RGD) rich non-mulberry (Antheraea assamensis, AA) silk fibroin in generating a functional liver construct. Three-dimensional (3D) porous silk scaffolds (BM, AA and BA) were physico-chemically characterized and functionally evaluated using human hepatocarcinoma cells (HepG2) and primary neonatal rat hepatocytes...
December 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29218832/necrotizing-enterocolitis-in-the-setting-of-milk-allergy-after-pediatric-living-donor-liver-transplantation
#10
Soichi Narumoto, Seisuke Sakamoto, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Akinari Fukuda, Shunsuke Nosaka, Rie Irie, Takako Yoshioka, Mureo Kasahara
NEC is an idiopathic intestinal mucosal injury that may progress to transmural bowel necrosis without mesenteric ischemia. NEC usually affects 7- to 10-day-old neonates following enteral feeding. A 10-month-old girl with no history of laparotomy underwent LDLT for acute liver failure. After starting enteral feeding on postoperative day 5, she developed abdominal distention. Diffuse PVG and PI were detected by radiologic modalities. Exploratory laparotomy revealed patchy necrosis of the intestine without perforation...
December 7, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29218739/successful-liver-transplantation-for-homozygous-protein-c-deficiency-with-a-type-ii-mutation-using-a-heterozygous-living-related-donor
#11
Alexander A Boucher, Lori Luchtman-Jones, Jaimie D Nathan, Joseph S Palumbo
No abstract text is available yet for this article.
December 8, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29216531/living-donor-liver-transplantation-for-adult-budd-chiari-syndrome-resection-without-replacement-of-retrohepatic-ivc-a-case-report
#12
Tarek Abdelazeem Sabra, Hideaki Okajima, Tetsuya Tajima, Ken Fukumitsu, Koichiro Hata, Kentaro Yasuchika, Toshihiko Masui, Kojiro Taura, Toshimi Kaido, Shinji Uemoto
INTRODUCTION: Suprahepatic caval resection and replacement of inferior vena cava (IVC) is standard procedure in deceased donor liver transplantation for patients with Budd-Chiari syndrome (BCS). However, replacement of IVC in living donor liver transplantation (LDLT) is difficult. We report a case of BCS successfully treated by LDLT without replacement of IVC. PRESENTATION OF CASE: A 52-years-old female with a primary BCS due to IVC thrombosis. A vena cava (VC) stent placed after angioplasty without improvement of the hepatic, portal venous flow and liver functions, Transjugular intrahepatic portosystemic shunt was considered and the patient had a rapid deterioration and increased ascites...
December 1, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29206088/hepatic-venous-outflow-obstruction-after-living-donor-liver-transplant-single-center-experience
#13
Suleyman Koc, Sami Akbulut, Vural Soyer, Mehmet Yilmaz, Bora Barut, Ramazan Kutlu, Sezai Yilmaz
OBJECTIVES: In this study, we share our approach for care of patients with hepatic venous outlet obstruction after living-donor liver transplant. MATERIALS AND METHODS: We retrospectively examined the demographic, clinical, and radiologic data of 35 patients who developed hepatic venous outlet obstruction after living-donor liver transplant. Patients were subgrouped on the basis of onset (8 patients with early onset [< 30 days posttransplant] and 27 patients with late onset [≥ 30 days posttransplant]) and postoperative survival (24 survivors, 11 nonsurvivors)...
December 5, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29205784/thoracic-epidural-analgesia-in-donor-hepatectomy-an-analysis
#14
Archna Koul, Deepanjali Pant, Swetha Rudhravaram, Jayashree Sood
BACKGROUND: To analyze whether supplementation of general anaesthesia with thoracic epidural analgesia (TEA) for right lobe donor hepatectomy is a safe modality of pain relief in terms of changes in postoperative coagulation profile, incidence of epidural catheter related complications and timing of removal of epidural catheter. METHODS: Retrospective analysis of the record of 104 patients who received TEA for right lobe donor hepatectomy was done. Platelet count, INR, ALT and AST were recorded postoperatively till the removal of the epidural catheter...
December 2, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29203983/role-of-hepatic-resection-for-hcc-in-the-era-of-transplantation-an-experience-of-two-tertiary-egyptian-centers
#15
Ahhmed Senbel, Youssef Elmahdy, Sameh Roshdy, Ashraf Khater, Fayez Shehatoo, Omar Farouk, Adel Fathi, Emad Hamed, Sherif Kotb, Adel Denwer
The surgical treatments of hepatocellular carcinoma (HCC) in a cirrhotic liver include both hepatic resection and liver transplant. While the liver transplant is considered as a golden therapy, it has some obstacles including shortage of organs especially living donors, economic circumstances, and the progression of a tumor while waiting for the transplant so the second choice which is resection should have a role. In this study, 84 patients with HCC (who were legible for transplant according to Milan and extended selection criteria) were enrolled for hepatic resection...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29196972/proximal-total-splenic-artery-embolization-for-refractory-hepatic-encephalopathy
#16
Harufumi Maki, Junichi Kaneko, Junichi Arita, Nobuhisa Akamatsu, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Sumihito Tamura, Hidemasa Takao, Eisuke Shibata, Norihiro Kokudo
A Japanese woman with a history of Kasai operation for biliary atresia had living-donor liver transplantation at the age of 22. The first episode of refractory HE and late cellular rejection was treated by a high dose of methylprednisolone. The second episode of refractory HE was treated by balloon-occluded retrograde transvenous obliteration for a spleno-renal shunt. However, the third episode of refractory HE occurred 11 years after liver transplantation. The liver cirrhosis and hypersplenism were present with a Child-Pugh score of C-10...
December 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29194959/standardized-hybrid-living-donor-hemi-hepatectomy-in-adult-to-adult-living-donor-liver-transplantation
#17
Susumu Eguchi, Akihiko Soyama, Takanobu Hara, Koji Natsuda, Satomi Okada, Takashi Hamada, Taiichiro Kosaka, Shinichiro Ono, Tomohiko Adachi, Masaaki Hidaka, Mitsuhisa Takatsuki
The aim of this study was to analyze the most updated and largest outcome of our standardized hybrid (laparoscopic mobilization and hepatectomy through midline incision) living donor (LD) hemihepatectomy compared to conventional laparotomy in adult-to-adult LD liver transplantation (LT). Of 237 adult-to-adult LDLT from August 1997 to March 2017, 110 LD underwent the hybrid procedure. Pre-operative and operative factors were analyzed and compared to conventional laparotomy (n=126). The median duration of laparoscopic usage was 26 minutes in the hybrid group...
December 1, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29187096/survey-of-living-organ-donors-experience-and-directions-for-process-improvement
#18
Timmy Li, M Katherine Dokus, Kristin N Kelly, Nene Ugoeke, James R Rogers, George Asham, Venkatesh Abhishek Sharma, Dominic J Cirillo, Mary K Robinson, Erika K Venniro, Jeremy G Taylor, Mark S Orloff, Scott McIntosh, Randeep Kashyap
INTRODUCTION: Understanding living organ donors' experience with donation and challenges faced during the process is necessary to guide the development of effective strategies to maximize donor benefit and increase the number of living donors. METHODS: An anonymous self-administered survey, specifically designed for this population based on key informant interviews, was mailed to 426 individuals who donated a kidney or liver at our institution. Quantitative and qualitative methods including open and axial coding were used to analyze donor responses...
September 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29176268/hemodynamic-implications-of-carbon-monoxide-co-and-nitrogen-oxide-no-during-living-donor-liver-transplantation
#19
Hyunyoung Lim, Suk-Koo Lee, Gaabsoo Kim
Carbon monoxide (CO) and nitrogen oxide (NO) affect vasodilation and cause hemodynamic change. Hemodynamic instability due to liver transplantation may result in poor prognosis of graft. This study investigated the hemodynamic implications of CO and NO levels measured using carboxyhemoglobin (COHb) and methemoglobin (MetHb) during living donor liver transplantation (LDLT). The hemodynamic instability with a pressor dose (norepinephrine equivalent) was estimated 1 hour after graft reperfusion. COHb and MetHb were used as indexes of CO and NO, and were measured using an arterial blood gas analyzer...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29170994/-no-go-donor-hepatectomy-in-living-donor-liver-transplantation
#20
Viniyendra Pamecha, Kishore G S Bharathy, Shyam S Mahansaria, Piyush K Sinha, Archana Rastogi, Shridhar V Sasturkar
BACKGROUND: Selection of appropriate donors after rigorous evaluation is of paramount importance in living-donor liver transplantation. Despite this, donor surgery may not proceed due to unforeseen reasons. The aim of this paper is to study reasons for "no go" donor hepatectomy in living liver donors. PATIENTS AND METHODS: Donor operations stopped after surgical start, directly due to donor safety-related reasons, qualified for inclusion as "no go" donor hepatectomy...
November 24, 2017: Hepatology International
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