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https://www.readbyqxmd.com/read/30116405/serum-level-of-d-lactate-in-patients-with-cystic-fibrosis-preliminary-data
#1
Sabina Więcek, Jerzy Chudek, Halina Woś, Maria Bożentowicz-Wikarek, Bożena Kordys-Darmolinska, Urszula Grzybowska-Chlebowczyk
D-Lactate is produced by the intestinal biota and later absorbed into circulation. Some patients with cystic fibrosis (CF) develop exocrine pancreatic insufficiency that may disturb the gut microbiome and enhance the production of D-lactate. However, this concept has not been studied yet. The aim of the study was to assess D-lactate concentration in relation to the occurrence of clinical features, activity of CF, and diet composition in paediatric patients. Patients and Method . Serum concentrations of D-lactate were measured in 38 CF patients (19 girls and 19 boys) from 6 months to 18 years of age...
2018: Disease Markers
https://www.readbyqxmd.com/read/30107701/-diagnosis-and-treatment-experience-of-161-cases-of-pancreatic-serous-cystic-neoplasm-in-single-center-and-analysis-of-cause-of-preoperation-misjudgement
#2
K R Lin, J Q Zhu, J Li, J C Gu, H C Li, R Wei, Y Guo, Y Y Wang, H Y Wang, D L Fu
Objective: To analyze the causes of preoperative miscarriage of pancreatic serous cystadenoma (SCN) and find the ways to improve it. Methods: Clinical data of 425 pancreatic cystic neoplasm patients who underwent surgical resection from January 2006 to December 2016 in Department of Pancreatic Surgery in Huashan Hospital were retrospectively analyzed.Excel database was created which covered 128 fields of 7 fields: general information of patients, preoperative blood biochemical indexes, tumor markers, surgical related data, postoperative complications, imaging findings and pathology...
August 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/30107632/the-spectrum-of-confocal-endomicroscopy-findings-in-a-cystic-neuroendocrine-tumor-of-the-pancreas
#3
Anjuli K Luthra, Christina A Arnold, Andrei V Manilchuk, Somashekar G Krishna
No abstract text is available yet for this article.
August 14, 2018: Endoscopy
https://www.readbyqxmd.com/read/30105857/from-somatic-mutation-to-early-detection-insights-from-molecular-characterization-of-pancreatic-cancer-precursor-lesions
#4
REVIEW
Catherine G Fischer, Laura D Wood
Pancreatic cancer arises from non-invasive precursor lesions, including pan creatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN), which are curable if detected early enough. Recently, these types of precursor lesions have been extensively characterized at the molecular level, defining the timing of critical genetic alterations in tumorigenesis pathways. The results of these studies deepen our understanding of tumorigenesis in the pancreas, providing novel insights into tumor initiation and progression...
August 13, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/30101015/atypical-presentation-of-a-cushion-sign-positive-stomach-gastrointestinal-stromal-tumor-with-cystic-formation-a-case-report
#5
Yutaka Okagawa, Tetsuya Sumiyoshi, Hideyuki Ihara, Shutaro Oiwa, Kaho Tokuchi, Masahiro Yoshida, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Michiaki Hirayama, Hitoshi Kondo, Yumiko Oyamada, Yo Kawarada, Shuji Kitashiro, Shunichi Okushiba
Gastrointestinal stromal tumors (GIST) typically appear as solid masses, and cystic formation is uncommon. Most stomach GISTs with cystic formation progress outside the gastric wall and are frequently misdiagnosed as epigastric cystic tumors derived from pancreas or liver. An asymptomatic 72-year-old male underwent esophagogastroduodenoscopy, which revealed a submucosal tumor (SMT), approximately 50 mm in diameter, at the anterior wall of the gastric angle. The SMT was very soft with positive cushion sign. Endoscopic ultrasonography and contrast-enhanced computed tomography revealed that the SMT was a cystic tumor with solid component...
August 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/30098614/how-long-should-patients-with-cystic-lesions-of-the-pancreas-be-followed
#6
REVIEW
Caitlin A McIntyre, Peter J Allen
No abstract text is available yet for this article.
September 2018: Advances in Surgery
https://www.readbyqxmd.com/read/30093986/intraductal-papillary-mucinous-neoplasm-originating-from-a-heterotopic-pancreas-within-the-jejunum-a-case-report
#7
Eiji Noda, Kenji Kuroda, Tomohisa Sera, Takuya Mori, Haruhito Kinoshita, Tsuyoshi Hasegawa, Hitoshi Teraoka, Takaaki Chikugo
We report a case of intraductal papillary mucinous neoplasm arising within the heterotopic pancreatic tissue which was found incidentally in the jejunum during surgery for bowel obstruction. A 54-year-old female patient was admitted to our hospital due to sudden abdominal pain. In preoperative findings, we diagnosed bowel obstruction and performed surgery. Intra-operative findings showed adhesive intestinal obstruction, we performed synechiotomy for adhesion release. During surgery, when searching the small intestine, we coincidentally found a tumor in the jejunum and partial resected the jejunum...
August 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/30086651/differentiation-of-intrapancreatic-accessory-spleen-from-small-hypervascular-neuroendocrine-tumor-of-the-pancreas-textural-analysis-on-contrast-enhanced-computed-tomography
#8
Xubo Lin, Lei Xu, Aiqin Wu, Chuangen Guo, Xiao Chen, Zhongqiu Wang
Background Intrapancreatic accessory spleens (IPASs) are usually misdiagnosed as pancreatic neuroendocrine tumors (PNETs). Texture analysis is valuable in tumor detection, diagnosis, and staging. Purpose To identify the potential of texture features in differentiating IPASs from small hypervascular PNETs. Material and Methods Twenty-one patients with PNETs and 13 individuals with IPASs who underwent pretreatment dynamic contrast-enhanced computed tomography (CT) were retrospectively analyzed. The routine imaging features-such as location, size, margin, cystic or solid appearance, enhancement degree and pattern, and lymph node enlargement-were recorded...
August 7, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/30085364/endoscopic-diagnosis-of-cystic-lesions-of-the-pancreas
#9
REVIEW
Ken Kamata, Masayuki Kitano
Endoscopic methods are increasingly used in the diagnosis of cystic lesions of the pancreas. The two major endoscopic approaches are endoscopic ultrasonography (EUS) and trans-papillary diagnosis. EUS-guided fine needle aspiration cytology and EUS-guided fine needle-based confocal laser endomicroscopy have been employed in the differential diagnosis of mucinous and non-mucinous pancreatic cysts. EUS is the most sensitive modality for detecting mural nodules (MNs) in IPMNs. Contrast-enhanced harmonic EUS (CH-EUS), as an add-on to EUS, is useful for identifying and characterizing MNs...
August 7, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/30080687/solid-pseudo-papillary-tumor-mimicking-as-complicated-pseudocyst-multimodality-imaging-and-pathological-correlation
#10
Sophie Turpin, Marjorie Perron, Stéphanie Vairy, Sébastien Bénali, Amélie Damphousse
Pancreatic neoplasm is very rare in the pediatric population. Malignant tumors represent less than 0.2% of pediatric cancer-related mortality. Pancreas lesions can be from exocrine or endocrine origin or present themselves as cystic masses. Clinical, biological, and radiological findings usually are sufficient to establish diagnosis, but in some cases, they may be misleading. We present the case of a young patient presenting a pancreatic mass where anatomical and metabolic characteristics of the lesion were discordant to the final diagnosis...
August 4, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/30075493/significance-of-mri-in-the-diagnosis-and-differentiation-of-clear-cell-sarcoma-of-tendon-and-aponeurosis-ccsta-a-case-report
#11
Kalyan Sharma, Sudhir Kumar Yadav, Bimbadhar Valluru, Ling Liu
RATIONALE: Clear cell sarcoma of tendon and aponeurosis (CCSTA) or soft parts is a rare malignant melanin producing tumor entity that is derived from the neural crest cells originating from soft tissues displaying melanocytic differentiation. Diagnosis of CCSTA is difficult as it is dependent on age, size, location, necrosis, calcifications, cystic degeneration, and local to distant metastatic deposits. These tumors have very poor prognosis with a survival rate of 5-10 years because of local recurrence, early to late metastasis to lymph nodes, lungs, bones, and liver...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30063495/does-surgical-margin-impact-recurrence-in-noninvasive-intraductal-papillary-mucinous-neoplasms-a-multi-institutional-study
#12
Vikrom K Dhar, Nipun B Merchant, Sameer H Patel, Michael J Edwards, Koffi Wima, Joseph Imbus, Daniel E Abbott, Sharon M Weber, Raphael Louie, Hong J Kim, Robert C G Martin, Charles R Scoggins, David J Bentrem, Michael T LeCompte, Kamran Idrees, Alexandra G Lopez-Aguiar, Shishir K Maithel, David A Kooby, Daniel A Franco, Danny Yakoub, Syed A Ahmad
OBJECTIVE: The relevance of margin positivity on recurrence after resection of intraductal papillary mucinous neoplasms (IPMNs) is poorly defined and represents one reason controversy remains regarding optimal surveillance recommendations. METHODS: Patients undergoing surgery for noninvasive IPMN at 8 academic medical centers from the Central Pancreas Consortium were analyzed. A positive margin was defined as presence of IPMN or pancreatic intraepithelial neoplasia...
September 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30052815/four-class-tumor-staging-for-early-diagnosis-and-monitoring-of-murine-pancreatic-cancer-using-magnetic-resonance-and-ultrasound
#13
Erica Dugnani, Valentina Pasquale, Paolo Marra, Daniela Liberati, Tamara Canu, Laura Perani, Francesco De Sanctis, Stefano Ugel, Francesca Invernizzi, Antonio Citro, Massimo Venturini, Claudio Doglioni, Antonio Esposito, Lorenzo Piemonti
Background: The widely-used genetically engineered mouse LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre, termed KPC, spontaneously develops pancreatic cancer mirroring all phases of the carcinogenesis but in asynchronous manner. Preclinical studies need defined criteria for the enrollment of the KPC sharing the same stage of carcinogenesis. Aim: To define a tumor staging criteria using magnetic resonance and ultrasound and then to correlate the imaging stage with overall survival of KPC mice...
July 24, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/30050709/malignant-phyllodes-tumor-of-the-breast-with-metastasis-to-the-pancreas-a-case-report-and-review-of-literature
#14
R A Amir, Rola S Rabah, S S Sheikh
Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term "cystosarcoma phyllodes" based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, "cystosarcoma" was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/30048483/sonographic-pancreas-echogenicity-in-cystic-fibrosis-compared-to-exocrine-pancreatic-function-and-pancreas-fat-content-at-dixon-mri
#15
Trond Engjom, Giedre Kavaliauskiene, Erling Tjora, Friedemann Erchinger, Gaute Wathle, Birger Norderud Lærum, Pål Rasmus Njølstad, Jens Brøndum Frøkjær, Odd Helge Gilja, Georg Dimcevski, Ingfrid Salvesen Haldorsen
OBJECTIVE: Fatty infiltration of the pancreas is a dominating feature in cystic fibrosis (CF). We evaluate the association between pancreatic fat content assessed by Dixon magnetic resonance imaging (MRI), pancreatic echogenicity at ultrasonography (US) and exocrine function in CF patients and healthy controls (HC). MATERIAL AND METHODS: Transabdominal US, pancreatic Dixon-MRI and diffusion-weighted imaging (DWI) were performed in 21 CF patients and 15 HCs. Exocrine function was assessed by endoscopic secretin test and fecal elastase...
2018: PloS One
https://www.readbyqxmd.com/read/30043132/medullary-carcinoma-of-the-pancreas-radiologically-followed-up-as-a-cystic-lesion-for-9-years-a-case-report-and-review-of-the-literature
#16
Akikazu Yago, Mitsuko Furuya, Ryutaro Mori, Yasuhiro Yabushita, Yu Sawada, Takafumi Kumamoto, Ryusei Matsuyama, Michio Shimizu, Itaru Endo
BACKGROUND: Medullary carcinoma of the pancreas (MCP) is a rare malignant pancreatic tumor. The World Health Organization classification defines the tumor as a subtype of pancreatic ductal carcinomas. MCP is histologically characterized as having highly pleomorphic cells with syncytial morphology, expansive tumor growth, and necrosis. The pathogenesis and clinical course of MCP are largely unknown. Herein, we report an unusual case of MCP that was radiologically followed up for 9 years prior to surgical intervention...
July 24, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/30032626/cyst-wall-brushing-exploring-the-limits-of-cytology
#17
EDITORIAL
Belén Martínez Moreno, José Ramón Aparicio Tormo
With the increasingly widespread use of imaging techniques pancreatic cystic lesions (PCLs) are now commonly identified. Their prevalence among the symptom-free population ranges from 2.4% to 13.5%. However, a recent study by our group revealed PCLs in up to 21.5% of patients undergoing endoscopic ultrasound (EUS) for non-pancreas conditions, an incidence that increases with age. Identifying PCLs in an otherwise asymptomatic population has become a significant clinical issue.
August 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29995757/cystic-lymphangioma-of-pancreas-a-rare-case-report-and-review-of-the-literature
#18
Diyu Chen, Xiaode Feng, Zhen Lv, Xiaofeng Xu, Chaofeng Ding, Jian Wu
RATIONALE: Lymphangiomas are benign lymphatic malformations that mostly occur in the neck and axillary regions. Abdominal lymphangioma is a rare type of this tumor, and pancreatic lymphangioma accounts for less than 1% of all lymphangiomas. In this report, we firstly reveal the application of ultrasound-guided puncture drainage combined with cell morphological examination for the diagnosis of pancreatic lymphangioma. PATIENT CONCERNS: A 35-year-old male patient was admitted to our hospital with recurrent abdominal pain and general weakness for 1 week...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29981674/cystic-dystrophy-of-the-duodenal-wall-in-heterotopic-pancreas-with-groove-pancreatitis-a-diagnostic-and-therapeutic-challenge
#19
Sorin T Barbu, Dragos Valeanu, Alexandrina Muresan, Doru Munteanu, Florin Casoinic
Background: Cystic dystrophy of heterotopic pancreas is a benign, rare disease characterized by development of true cysts into the duodenal wall. Non-specific clinical manifestations and difficult to interpret imaging provide a diagnostic challenge, especially when pancreatic cancer is suspected. Surgical treatment (pancreatoduodenectomy) offer best outcomes. CASE REPORT: A 48 years-old man, chronic alcohol consumer, with a history of recurrent mild acute pancreatitis episodes, was diagnosed in 2010 with segmental chronic pancreatitis complicated by a 4cm pseudocyst in the pancreatic head...
May 2018: Chirurgia
https://www.readbyqxmd.com/read/29961928/new-insights-into-the-role-of-hnf-1%C3%AE-in-kidney-patho-physiology
#20
REVIEW
Silvia Ferrè, Peter Igarashi
Hepatocyte nuclear factor-1β (HNF-1β) is an essential transcription factor that regulates the development and function of epithelia in the kidney, liver, pancreas, and genitourinary tract. Humans who carry HNF1B mutations develop heterogeneous renal abnormalities, including multicystic dysplastic kidneys, glomerulocystic kidney disease, renal agenesis, renal hypoplasia, and renal interstitial fibrosis. In the embryonic kidney, HNF-1β is required for ureteric bud branching, initiation of nephrogenesis, and nephron segmentation...
July 1, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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