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Endocrinology, Diabetes,Obesity

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https://www.readbyqxmd.com/read/30261744/use-of-metformin-for-weight-management-in-children-and-adolescents-with-obesity-in-the-clinical-setting
#1
Kathryn E Kyler, Rachel B Kadakia, Hannah L Palac, Soyang Kwon, Adolfo J Ariza, Helen J Binns
Use of metformin for weight loss for children in a clinical setting has not been well described; therefore, we aimed to ide.epsy characteristics of obese patients prescribed metformin in a clinical setting and evaluate changes in anthropometric measures. Records of obese patients aged 10 to 18 years without diabetes attending an academic endocrinology practice from 2009 to 2013 were reviewed. Analyses assessed changes in anthropometric measures (weight, body mass index [BMI], and BMI z-score) over 12 months between those prescribed metformin (n = 49) and those not prescribed metformin (n = 142)...
September 27, 2018: Clinical Pediatrics
https://www.readbyqxmd.com/read/30236381/trajectories-of-changes-in-glucose-tolerance-in-a-multiethnic-cohort-of-obese-youths-an-observational-prospective-analysis
#2
Alfonso Galderisi, Cosimo Giannini, Ram Weiss, Grace Kim, Veronika Shabanova, Nicola Santoro, Bridget Pierpont, Mary Savoye, Sonia Caprio
BACKGROUND: Type 2 diabetes is preceded by a prediabetic stage of impaired glucose tolerance that affects 10-23% of youth and is expected to double over the next decade. The natural history of impaired glucose tolerance and the determinants of β-cell dynamic response have never been investigated longitudinally in young people. We aimed to investigate the clinical and metabolic determinants of longitudinal glucose tolerance changes and β-cell function in a multiethnic cohort of obese youth...
October 2018: The lancet child & adolescent health
https://www.readbyqxmd.com/read/30215735/lixisenatide-reduces-chylomicron-triacylglycerol-due-to-increased-clearance
#3
Martin B Whyte, Fariba Shojaee-Moradie, Sharaf E Sharaf, Nicola C Jackson, Barbara Fielding, Roman Hovorka, Jeewaka Mendis, David Russell-Jones, A Margot Umpleby
Context: GLP-1 agonists control postprandial glucose and lipid excursion in type 2 diabetes; however the mechanism(s) are unclear. Objective: To determine the mechanism(s) of postprandial lipid and glucose control with lixisenatide (GLP-1 analogue) in type 2 diabetes. Design: Randomised, double-blind, cross-over study. Setting: Centre for Diabetes, Endocrinology, and Research, Royal Surrey County Hospital, Guildford, UK...
September 11, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30213304/-bone-and-metabolism
#4
Charlotte Marsot, Philippe Chanson, Françoise Borson-Chazot
Bone is now considered as a particular endocrine organ. Its endocrine function is not yet fully understood and has been the subject of several conferences at the European Society of Endocrinology Congress 2018. Bone regulates phosphate metabolism by secreting fibroblast growth factor 23; it also regulates glucose metabolism via osteocalcin and energy metabolism, thanks to lipocalin 2, a new hormone acting on the brain. In addition, the incidence of diabetes continues to grow, and its impact on bone has been demonstrated, with an increased risk of fractures regardless the type of diabetes...
September 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/30181855/cross-sectional-correlates-of-myeloperoxidase-and-alpha-1-acid-glycoprotein-with-adiposity-atherogenic-and-hematological-indices-in-metabolic-syndrome-patients-with-or-without-diabetes
#5
Reem Sami Alquoqa, Violet Kasabri, Randa Naffa, Amal Akour, Yasser Bustanji
Background: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are associated with obesity, which triggers the release of inflammatory substances. Myeloperoxidase (MPO), a peroxidase enzyme, and alpha-1-acid glycoprotein (AGP), an acute-phase protein, are known to be released in patients with inflammatory conditions and cardiovascular disease (CVD). Methods: In this study, we investigated the correlation between MPO and AGP levels in pre/diabetic and MetS patients by conducting a cross-sectional study at The University of Jordan Hospital (UoJH) at the diabetes and endocrinology outpatient clinics...
September 2018: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30177468/assessing-use-of-patient-focused-pharmacotherapy-in-glycemic-management-through-the-diabetes-collaborative-registry-dcr
#6
Suzanne V Arnold, Darren K McGuire, Silvio E Inzucchi, Fengming Tang, Sanjeev N Mehta, Carolyn S P Lam, Abhinav Goyal, Laurence S Sperling, Nathan D Wong, Niklas Hammar, Peter Fenici, Mikhail Kosiborod
BACKGROUND: Although practice guidelines stress individualization of glucose management in patients with type 2 diabetes (T2D), the extent to which providers take patient factors into account when selecting medications is not well known. METHODS: Diabetes Collaborative Registry (DCR) is an outpatient diabetes registry including primary care, cardiology, and endocrinology practices. T2D medications were grouped as those which may be suboptimal for key patient subgroups, and we examined patient factors associated with use of these agents using hierarchical, multivariable Poisson models...
November 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/30091111/evolution-of-body-mass-index-in-children-with-type-1-diabetes-mellitus
#7
Marijke De Keukelaere, Steffen Fieuws, Nele Reynaert, Eva Vandoorne, Kristel Vande Kerckhove, Willeke Asscherickx, Kristina Casteels
The prevalence of childhood overweight and obesity has risen during the last 30 years, not only in children with type 2 diabetes, but also those with type 1 (T1D) and this is linked with an increased cardiovascular risk. A better understanding of weight patterns in the years after diagnosis of T1D is important to identify those children with a risk for excess weight gain and strategies to decrease this. We retrospectively analyzed data of all children with T1D followed at the department of Pediatric Endocrinology Leuven and diagnosed between 1991 and 2015...
November 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/30062073/correlation-between-neck-circumference-and-gestational-diabetes-mellitus-and-associated-risk-factors-during-pregnancy
#8
Dr KhushBakht, Saadon Mazhar, Amanullah Bhalli, Aqeela Rashid, Khurshid Khan, Uzma Jahanzaib
Introduction Due to normal physiological changes in various anthropometric indices during pregnancy, the routine measurements of body weight, height, waist circumference, and waist-to-hip ratio are deemed inappropriate in predicting obesity and risk of gestational diabetes mellitus in pregnancy. Neck circumference is a novel marker to determine the risk of gestational diabetes in pregnancy. We conducted this study to determine the correlation between neck circumference and gestational diabetes mellitus and its associated risk factors...
May 28, 2018: Curēus
https://www.readbyqxmd.com/read/30052854/the-paraventricular-nucleus-of-the-hypothalamus-development-function-and-human-diseases
#9
Cheng Qin, Jiaheng Li, Ke Tang
The paraventricular nucleus of the hypothalamus (PVH), located in the ventral diencephalon adjacent to the third ventricle, is a highly conserved brain region present in species from zebrafish to humans. The PVH is composed of three main types of neurons, magnocellular, parvocellular, and long-projecting neurons, which play imperative roles in the regulation of energy balance and various endocrinological activities. In this review, we focus mainly on recent findings about the early development of the hypothalamus and the PVH, the functions of the PVH in the modulation of energy homeostasis and in the hypothalamus-pituitary system, and human diseases associated with the PVH, such as obesity, short stature, hypertension, and diabetes insipidus...
September 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29980463/efficacy-of-video-based-education-program-in-improving-metabolic-surgery-perception-among-patients-with-obesity-and-diabetes
#10
Yen-Yi Juo, Matthew J Freeby, Vanessa Arguello, Linda Liu, Emily Huang, Erik Dutson, Yijun Chen
BACKGROUND: Metabolic surgery remains underutilized despite its efficacy and safety. Poor perception of surgery has been cited as one of the major reasons. OBJECTIVES: Evaluate current patient perceptions about metabolic surgery and measure the impact a video-based education program has on changing the perceptions of patients diagnosed with obesity and type 2 diabetes. SETTING: A university hospital in the United States. METHODS: A prospective interventional study was performed at an endocrinology clinic...
September 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29808089/noncoding-rnas-carried-by-extracellular-vesicles-in-endocrine-diseases
#11
REVIEW
Margherita A C Pomatto, Chiara Gai, Maria Chiara Deregibus, Ciro Tetta, Giovanni Camussi
RNA molecules are essential and fine regulators of important biological processes. Their role is well documented also in the endocrine system, both in physiological and pathological conditions. Increasing interest is arising about the function and the importance of noncoding RNAs shuttled by extracellular vesicles (EVs). In fact, EV membrane protects nucleic acids from enzyme degradation. Nowadays, the research on EVs and their cargoes, as well as their biological functions, faces the lack of standardization in EV purification...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29754804/diabetes-mellitus-and-cardiovascular-risk-update-of-the-recommendations-of-the-diabetes-and-cardiovascular-disease-working-group-of-the-spanish-diabetes-society-sed-2018
#12
Francisco Arrieta, Pedro Iglesias, Juan Pedro-Botet, Antonio Becerra, Emilio Ortega, Juan Carlos Obaya, Andreu Nubiola, Gonzalo Fernando Maldonado, Maria Del Mar Campos, Romina Petrecca, José Luis Pardo, Víctor Sánchez-Margalet, José Juan Alemán, Jorge Navarro, Santiago Duran, Francisco Javier Tébar, Manuel Aguilar, Fernando Escobar
This document is an update to the clinical practice recommendations for the management of cardiovascular risk factors in diabetes mellitus. The consensus is made by members of the Cardiovascular Risk Group of the Spanish Diabetes Society. We have proposed and updated interventions on lifestyle, pharmacological treatment indicated to achieve therapeutic objectives according to the levels of HbA1c, degree of obesity, hypertension, hyperlipidemia, heart failure, platelet antiagregation, renal insufficiency, and diabetes in the elderly, as well as new biomarkers of interest in the evaluation of cardiovascular risk in individuals with diabetes mellitus...
May 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29752333/the-endocrinology-of-male-breast-cancer
#13
REVIEW
Ian S Fentiman
Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2 ) levels from hepatic conversion of androgen...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29745915/association-of-diabetes-compensation-with-sleeping-habits-and-well-being-in-patients-with-diabetes-mellitus
#14
L Navasardyan, A Аvetisyan, M Simonyan, E Aghajanova
Recent data estimates that sleep deprivation and poor quality of night sleep have an impact on the incidence and prevalence of both obesity and type 2 diabetes, as well as cardiovascular events in all ages. The aim of this work is to evaluate the association between diabetes compensation and sleep quality and quantity, comparing patients with type 1 and type 2 diabetes, as well as to establish any potential connection with "screen" time, physical activity and well-being. For this reason 49 patients with type 1 (n=28) and type 2 DM (n=21) were investigated...
April 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29713190/recurrent-candidal-intertrigo-challenges-and-solutions
#15
REVIEW
Ahmet Metin, Nursel Dilek, Serap Gunes Bilgili
Intertrigo is a common inflammatory dermatosis of opposing skin surfaces that can be caused by a variety of infectious agents, most notably candida, under the effect of mechanical and environmental factors. Symptoms such as pain and itching significantly decrease quality of life, leading to high morbidity. A multitude of predisposing factors, particularly obesity, diabetes mellitus, and immunosuppressive conditions facilitate both the occurrence and recurrence of the disease. The diagnosis of candidal intertrigo is usually based on clinical appearance...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#16
REVIEW
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29649538/identification-of-factors-to-increase-efficacy-of-telemedicine-screening-for-diabetic-retinopathy-in-endocrinology-practices-using-the-intelligent-retinal-imaging-system-iris-platform
#17
Sapna Naik, Charles C Wykoff, William C Ou, Jonathan Stevenson, Sunil Gupta, Ankoor R Shah
AIMS: Diabetic retinopathy (DR) and diabetic macular edema (DME) can be evaluated using telemedicine systems, such as the Intelligent Retinal Imaging Systems (IRIS), in patients with Diabetes Mellitus (DM). In an endocrinology-based population utilizing IRIS we determine prevalence rates of DR and DME, and identify associated epidemiologic correlations. METHODS: This is a multicenter, retrospective chart review using screening data from IRIS. Centers for Disease Control and Prevention (CDC) data on epidemiologic variables (by county) namely, prevalence of DM, incidence of DM, obesity, and time of physical inactivity, were compared against prevalence rates of DR found at screening...
June 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29527307/compliance-with-guidelines-for-disease-management-in-diabetes-results-from-the-swissdiab-registry
#18
Katrin E Schimke, Frida Renström, Sandro Meier, Christoph Stettler, Michael Brändle
Objective: Tight glycemic control and aggressive treatment of additional cardiovascular risk factors can substantially reduce risk of diabetes-related complications. In 2013, the Swiss Society of Endocrinology and Diabetology (SSED) established national criteria on good disease management in diabetes, but little is known about compliance in clinical care. Here we assessed to what extent patients from two tertiary care centers in the German-speaking part of Switzerland enrolled in the Swiss Diabetes (SwissDiab) Registry adhere to the SSED criteria...
2018: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29459441/mechanisms-in-endocrinology-lessons-from-growth-hormone-receptor-gene-disrupted-mice-are-there-benefits-of-endocrine-defects
#19
REVIEW
Reetobrata Basu, Yanrong Qian, John J Kopchick
Growth hormone (GH) is produced primarily by anterior pituitary somatotroph cells. Numerous acute human (h) GH treatment and long-term follow-up studies and extensive use of animal models of GH action have shaped the body of GH research over the past 70 years. Work on the GH receptor (R)-knockout (GHRKO) mice and results of studies on GH-resistant Laron Syndrome (LS) patients have helped define many physiological actions of GH including those dealing with metabolism, obesity, cancer, diabetes, cognition and aging/longevity...
May 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29413162/tackling-childhood-obesity-a-step-in-the-right-direction
#20
EDITORIAL
The Lancet Diabetes Endocrinology
No abstract text is available yet for this article.
February 2018: Lancet Diabetes & Endocrinology
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