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Kidney tranplantation

Hélène Lazareth, Daniel Cohen, Viorel Vasiliu, Claire Tinel, Frank Martinez, Jean-Pierre Grünfeld, Marie-France Mamzer, Christophe Legendre, Rebecca Sberro-Soussan
Renal transplantation has been associated with a significantly increased risk of developing cancer, including bladder neoplasia, with urothelial carcinoma being the most frequent type of bladder cancer. Bladder paraganglioma, also referred to as extra-adrenal pheochromocytoma, is a rare but severe condition that may cause a severe hypertensive crisis during handling and mobilization of the tumor. We herein present the case of a 67-year-old kidney transplant recipient with a bladder polyp consistent with paraganglioma of the bladder...
April 2017: Molecular and Clinical Oncology
Y D Xu, R L Guan, Y Y Wu, H E Lei, B C Yang, H X Li, L Wang, Y L Guo, Z C Xin
OBJECTIVE: To study the feasibility of transplantation of normal rat penile corpus cavernosum and major pelvic ganglion (MPG) into the renal subserous region of a Nu/Nu mouse based on allograft technology. METHODS: Penile corpus cavernosum and MPG, harvested from Sprague-Dawley (SD) rats under sterile condition, were transplanted underneath the kidney capsule of Nu/Nu mice through the microsurgery instruments and surgery microscope. The histopathologic changes and cellular proliferation in the transplanted penile corpus cavernosum and MPG were then analyzed at the end of 1week and 4 weeks after transplantation...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
B Schmidt, K Bergmann, J Kaufeld, A Melk
OBJECTIVE: Left ventriuclar mass (LVM) is a strong predictor of cardiovascular events. In patients with chronic kidney disease and in patients on dialysis left ventricular hypertrophy is highly prevalent. Overcoming uremia by renal transplantation might improve LVM. However, after transplantation treatment with steroids and calcineurin inhibitors increases blood pressure and therefore might counteract the positive effect of restoring renal function.We performed a metaanalysis of the available evidence from observational studies in patientts after renal tranplantation...
September 2016: Journal of Hypertension
Hans van Goudoever
Paediatric tertiary care is highly centralized in the Netherlands. The country is small (16 million inhabitants, overall unemployment rates were approximately 7 % in 2014, while young adult (< 25 years) unemployment rates were 12 %) with the majority of the population living in Amsterdam and Rotterdam and their neighbouring cities/villages. There are 90 hospitals taking care for children in the Netherlands. Specific types of highly specialized care, such as transplantation, are provided in a maximum of three centres (kidney transplants in 3, bone marrow tranplants in 2, liver transplants in only one center), while neonatal intensive care is offered in 10 hospitals...
2015: Pädiatrie und Pädologie
Isabel Fonseca, José Carlos Oliveira, Josefina Santos, Jorge Malheiro, La Salete Martins, Manuela Almeida, Leonídio Dias, Sofia Pedroso, Luísa Lobato, António Castro Henriques, Denisa Mendonça
CONTEXT AND OBJECTIVE: Based on evidence that leptin and adiponectin are removed from circulation primarily by the kidney, we designed a study to examine the longitudinal changes of these adipokines during the first week after kidney transplantation (KTx) and to test the hypothesis that higher levels of leptin and/or adiponectin could be early biomarkers of delayed graft function (DGF=dialysis requirement during the first post-transplant week) and acute rejection. STUDY DESIGN: Repeated-measures prospective study...
February 2015: Metabolism: Clinical and Experimental
Federica Neve Vigotti, Gabriella Guzzo, Irene Capizzi, Luigi Teta, Davide Ippolito, Sara Mirasole, Domenica Giuffrida, Paolo Avagnina, Giorgina Piccoli
UNLABELLED: Obesity is increasingly encountered in dialysis patients, who have difficulty to lose weight. Several Transplant Centres require BMI <30-35 Kg/m2 at waiting-list. Thus, losing weight becomes a must for young obese patients, however the best policy to obtain it (if any) is not defined. The aim of the present case report is to suggest that tailored dialysis and intensive diets could be a successful combination, that should be tested on a larger scale. A 56-year-old obese male patient (BMI 37...
March 2014: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Luciana Borges Giarola, Rosiane Ribeiro Dos Santos, Maria Cristina Bronharo Tognim, Sueli Donizete Borelli, João Bedendo
The objective of the present study was to determine the frequency of Staphylococcus aureus nasal carriage among dialysis and kidney transplant patients, to identify the antimicrobial resistance profile of these strains and to verify their genetic profiles with the RW3A primer. The study included 159 individuals, comprising 111 dialysis and 48 kidney transplant patients. Of the 48 transplant patients, 75% were positive for S. aureus, whereas 49% of the 111 dialysis patients were carriers. Two samples yielded conflicting results for oxacillin sensitivity between the disk diffusion and minimum inhibitory concentration (MIC) assays: both were sensitive by the disk diffusion assay and resistant by MIC (4 μg/ml)...
July 2012: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Olivier Aubert, Louise Galmiche, Flore Rozenberg, Alyette Duquesne, Anne Scemla, Marion Rabant, Marianne Leruez, Hélène Laude, Christophe Legendre, Rebecca Sberro-Soussan
No abstract text is available yet for this article.
April 2013: Kidney International
L Piros, Zs Máthé, K Földes, R M Langer
INTRODUCTION: The occurrence of postoperative incisional hernia is more frequent after simultaneous pancreas-kidney transplantation compared with other transplanted parenchymal organs. These complications are especially dangerous in this patient population, because they can compromise the survival of the transplanted organ. METHODS: We performed a retrospective review of a series of adult patients with incisional herniae after 23 consecutive simultaneous pancreas-kidney transplantations between January 2004 and June 2010 seeking to identify risk factors...
May 2011: Transplantation Proceedings
Lluís Guirado
Renal transplant is the best option of treatment of chronic kidney disease and the shortage of cadaveric donors has caused the rapid increase of living donor programs. Provided that an important proportion of the donor-recipient pairs are incompatible between them, ABO incompatibility or positive cross-match test, one of the most important challenges of last decade, has been the solution of the above mentioned problem. For it there have begun the crossed-over transplant programs (also called donors' exchange programs) in his different combinations and these kind of transplants has been consolidated by an excellent results...
2010: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Piotr Myśliwiec, Hanna Myśliwiec, Dariusz Pawlak, Jacek Dadan, Włodzimierz Buczko, Krystyna Pawlak
AIM: Disturbances in amino acids metabolism are common in chronic renal failure and subside partially after renal tranplantation. Tryptophan (TRP) is one of the most important exogenous amino acids. Its main derivative is L-kynurenine (KYN). Disorders in the TRP metabolism via kynurenine pathway may lead to neurologic disturbances, hypertension and anaemia. The aim of this study was to assess peripheral kynurenine pathway in 28 renal allograft recipients (RAR) (12 women and 16 men) in comparison to 10 hemodialysed patients with chronic renal failure (CRF) and 10 healthy subjects...
2009: Przegla̧d Lekarski
Milivoje Vuković, Nebojsa Moljević, Zoran Milosević, Nenad Katanić, Dragan Krivokuća
INTRODUCTION: Liver transplantation is the most demanding of all solid organ tranplantations. It requires perfect organization and motivation of health care professionals, patients and their families. This article deals with the procedure for multiple organ procurement, reviews criteria for organ donation and describes the surgical tehnique for multiple organ procurement. DISCUSSION: Adequate selection and evaluation of cadaveric donors and of organs for transplantation should include early identification of potential donors, and early diagnosis of brain death...
July 2007: Medicinski Pregled
Behrooz Broumand
Iran is a tropical country with a land area of 1,648,000 square kilometers and a population of 68,100,000. Iran has a recorded history that dates back 2553 years. Its earliest medical school was Pasargad. Jondi Chapour University was founded 1753 years ago during the Sassanid dynasty as a center for higher education in medicine, philosophy, and pharmacology. Indeed, the idea of xenotransplantation dates back to days of Achaemenidae (Achaemenian dynasty), as evidenced by engravings of many mythologic chimeras still present in Persepolis...
June 2005: Experimental and Clinical Transplantation
Robert D Fitzgerald, Annelies Fitzgerald, Nadey S Hakim
During the first Yemeni Congress of Uro-Nephrology in Aden, an international team performed the first kidney tranplantations in the region. We report the difficulties encountered and discuss the pros and cons for transplantations in developing countries.
July 2004: International Surgery
T E Starzl, N Murase, A Demetris, M Trucco, J Fung
The evolution of clinical transplantation has hinged on 2 seminal turning points. The first was the demonstration in 1953 by Billingham, Brent, and Medawar that chimerism-associated tolerance could be induced deliberately in neonatal mice by infusing adult donor hematolymphopoietic cells. This discovery escalated in a straight line over the next 15 years to successful bone marrow transplantation in humans. The second turning point was the demonstration that organ allografts could self-induce tolerance under an umbrella of immunosuppression, or in some species without immunosuppression...
2000: Seminars in Liver Disease
Leushner, Wu, Wang, Howson, Metrakos
Background: Because spontaneous microchimerism has been reported in stable renal and hepatic allografts, the presence of donor-derived cells in recipient tissues was investigated in kidney and liver tranplant recipients. Methods and Results: Human lymphocyte antigen class II markers and Y-chromosome sequences in male donor-to-female recipient transplants were used for chimeric analysis. Human lymphocyte antigen typing was performed by group-specific polymerase chain reaction amplification and restriction fragment length polymorphism analysis, X-chromosome- and Y-chromosome-specific primers were used in a multiplex polymerase chain reaction analysis...
September 1997: Molecular Diagnosis
D K Klassen, E W Hoen-Saric, M R Weir, J C Papadimitriou, C B Drachenberg, L Johnson, E J Schweitzer, S T Bartlett
The clinical success of pancreas transplantation is limited by the difficulty in diagnosing rejection. In simultaneous pancreas kidney (SPK) transplantation, the diagnosis of pancreatic rejection is particularly difficult in the absence of clinical evidence of kidney rejection. Moreover, patients receiving only pancreas grafts will not have a concomitantly grafted kidney to serve as a "sentinel" for rejection. Percutaneous pancreas graft biopsy has been reported in a few small series but has not been adopted for broad clinical use...
March 27, 1996: Transplantation
C Hiesse, P Lang
No abstract text is available yet for this article.
August 1995: Transplantation Proceedings
N R Glass, K M Butt, D Moel, S L Kountz
In order to compare the results of renal transplantation in pediatric and adult recipients, a retrospective analysis of first transplants done at a single institution over a 6-yr period was carried out. The study included 21 pediatric and 196 adult recipients of cadaveric grafts, and 18 pediatric and 156 adult recipients of living related grafts. Pediatric and adult recipient groups were shown to be similar to each other with respect to donor-recipient HLA antigen matching and to causes of graft failure and patient mortality...
June 1980: Journal of Pediatric Surgery
J A van der Vliet, G G Persijn, G Kootstra, Q Lansbergen
In view of the persistent shortage of organ donors, the usability for transplantation of cadaveric kidneys from donors over 50 years of age was studied. Out of 5546 cadaveric kidneys, transplanted in the Eurotransplant area in the past ten years, 149 were from donors over 50 years of age. Apart from an increased early graft loss in the advanced age donor group, comparison of cumulative graft survival showed no negative influence of progressing donor age. It is concluded that donors over 50 years of age can be a valuable source of cadaveric kidneys for tranplantation...
1981: Scandinavian Journal of Urology and Nephrology. Supplementum
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