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Spleen Pathology

Niharika Singh, Ian Chin, Paul Gabriel, Emily Blaum, Sharmila Masli
The risk of developing lymphoma in patients with Sjögren's syndrome (SS) is 44 times higher than in the normal population with the most common lymphomas derived from marginal zone B (MZB) cells. Current understanding of the role of MZB cells in SS is primarily based on salivary gland pathology, while their contextual association with lacrimal glands and ocular manifestations largely remains unknown. We examined this possibility using a SS mouse model (thrombospondin-1 deficient (TSP1-/- )) with well-characterized ocular disease...
October 11, 2018: International Journal of Molecular Sciences
Lingling Qiu, Guobin Chang, Yulin Bi, Xiangping Liu, Guohong Chen
Avian leukosis virus subgroup J (ALV-J) can induce myeloid tumors and hemangiomas in chickens and causes severe economic losses with commercial layer chickens and meat-type chickens. Here, we generated ribominus RNA sequencing data from three normal chicken spleen tissues and three ALV-J-infected chicken spleen tissues. Structure analysis of transcripts showed that, compared to mRNAs and lncRNAs, chicken circRNAs shared relatively shorter transcripts and similar GC content. Differentially expression analysis showed 152 differentially expressed circRNAs with 106 circRNAs up regulated and 46 circRNAs down regulated...
2018: PloS One
Kit Fai Lee, Hon Ting Lok, Andrew K Y Fung, Charing C N Chong, Yue Sun Cheung, John Wong, Paul B S Lai
A 51-year-old man who was a hepatitis B carrier presented with ruptured hepatocellular carcinoma (HCC). Hepatic arterial embolization was performed for control of bleeding which was followed by staged open left lateral sectionectomy for tumor removal. Pathology confirmed a 3.5 cm ruptured subcapsular HCC in a cirrhotic liver with clear resection margin. However, the alpha-fetoprotein (AFP) increased from 14 to 72 µg/L after 7 months. A 1.7 × 0.8 cm nodule at left subdiaphragmatic region abutting on the spleen but no intrahepatic lesion was seen on computed tomography (CT)...
September 29, 2018: Journal of Robotic Surgery
Yue Wang, Fengyi Zhao, Eddy Rijntjes, Liping Wu, Qian Wu, Jing Sui, Yufeng Liu, Meng Zhang, Mingqian He, Pu Chen, Shiqian Hu, Peng Hou, Lutz Schomburg, Bingyin Shi
Purpose: To investigate the importance of dietary Se supply for hyperthyroidism. Methods: We performed a more in-depth analysis of a large cross-sectional study of 6152 participants from two counties within the Shaanxi Province, China, which are characterized by different habitual Se intakes, and investigated the effects of different dietary Se supply (0.02, 0.18, 0.6 or 2.0 ppm Se) on disease development in a mouse model of GD. Results: The cross-sectional study revealed a comparable prevalence of hyperthyroidism irrespective of Se intake in both counties...
September 27, 2018: Journal of Clinical Endocrinology and Metabolism
Éva Gyuris, Csaba Nemes, Tibor Magyar
Anatipestifer disease is a contagious disease caused by Riemerella anatipestifer, affecting primarily ducks, geese and turkeys, and characterised by listlessness, diarrhoea, sneezing, nasal discharge, and nervous signs. Sporadically, it occurs in a wide range of other domesticated and wild birds as well. The incidence and characteristics of the disease seen in the three main host species are summarised based on birds submitted for routine laboratory investigation in Hungary over the period 2010-2014. The infection was diagnosed in a higher percentage in geese (9...
September 2018: Acta Veterinaria Hungarica
Junko Masuda, Chiho Umemura, Miki Yokozawa, Ken Yamauchi, Takuya Seko, Michiaki Yamashita, Yumiko Yamashita
Selenoneine is an ergothioneine analog with greater antioxidant activity and is the major form of organic selenium in the blood, muscles, and other tissues of tuna. The aim of this study was to determine whether a selenoneine-rich diet exerts antioxidant activities that can prevent carcinogenesis in two types of colorectal cancer model in mice. We administrated selenoneine-containing tuna dark muscle extract (STDME) to mice for one week and used azoxymethane (AOM) and dextran sodium sulfate (DSS) for inducing colorectal carcinogenesis...
September 27, 2018: Nutrients
YanLing Ma, Anthony Gal, Michael Koss
Sarcoidosis is a multi-system disease of unknown etiology, usually affecting the respiratory tract and other organs, and is characterized by the formation of nonnecrotizing epithelioid granulomas. The diagnosis depends on a combination of a typical clinicoradiological presentation, the finding of nonnecrotizing epithelioid granulomas in a tissue biopsy, and exclusion of other possible diseases, especially those of infectious etiology. The granulomas contain epithelioid cells, giant cells, CD4+ T cells in their center, and CD8+ T lymphocytes and B lymphocytes at their periphery...
September 24, 2018: Seminars in Diagnostic Pathology
Stephanie A Montgomery, Ellen F Young, Phillip G Durham, Katelyn E Zulauf, Laura Rank, Brittany K Miller, Jennifer D Hayden, Feng-Chang Lin, John T Welch, Anthony J Hickey, Miriam Braunstein
New therapeutic strategies are needed to treat drug resistant tuberculosis (TB) and to improve treatment for drug sensitive TB. Pyrazinamide (PZA) is a critical component of current first-line TB therapy. However, the rise in PZA-resistant TB cases jeopardizes the future utility of PZA. To address this problem, we used the guinea pig model of TB and tested the efficacy of an inhaled dry powder combination, referred to as Pyrazinoic acid/ester Dry Powder (PDP), which is comprised of pyrazinoic acid (POA), the active moiety of PZA, and pyrazinoic acid ester (PAE), which is a PZA analog...
2018: PloS One
Sara Costa, Dalila Bevilacqua, Marco A Cassatella, Patrizia Scapini
An increasing body of literature supports a role for neutrophils as players in the orchestration of adaptive immunity. During acute and chronic inflammatory conditions, neutrophils rapidly migrate not only to sites of inflammation, but also to draining lymph nodes and spleen, where they engage bidirectional interactions with B- and T-lymphocyte subsets. Accordingly, a relevant role of neutrophils in modulating B-cell responses under homeostatic conditions has recently emerged. Moreover, specialized immunoregulatory properties towards B or T cells acquired by distinct neutrophil populations, originating under pathological conditions, have been consistently described...
September 27, 2018: Immunology
Qiang Yang, Xueyan Zhao, Yuyun Xing, Chao Jiang, Kai Jiang, Pan Xu, Weiwei Liu, Jun Ren, Lusheng Huang
Mucopolysaccharidosis type IIIB (MPS IIIB) is a rare genetic disorder caused by loss-of-function mutations in the NAGLU gene. Pigs are an ideal large-animal model for human diseases; however, a porcine model of MPS IIIB has not been reported. We have previously generated a heterozygous NAGLU -deficient ( NAGLU +/- ) Large White boar via a transgenic approach. Here we characterized phenotypes of the F1 offspring of this founder to establish a pig model for MPS IIIB. qRT-PCR revealed that the NAGLU expression level was significantly decreased in a variety of tissues in NAGLU +/- pigs...
September 26, 2018: Biology Open
Feng Xu, Wentao Sang, Ling Li, Xinyu He, Feng Wang, Taoqun Wen, Nan Zeng
Rimulus cinnamon is the dried twig of Cinnamomum cassia Presl. It is widely used in China for the treatment of inflammatory processes, amenorrhea, and other diseases. We aimed to study the protective effects of ethyl acetate extracts of R. cinnamon (EAE) on systemic inflammation and lung injury in endotoxin-poisoned mice. EAE was administered 5 d prior to lipopolysaccharide (LPS) challenge with 15 mg/kg LPS. The administration of EAE increased the levels of interferon-γ (IFN-γ) and decreased the levels of interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α) in the serum...
September 27, 2018: Drug and Chemical Toxicology
H R Otsyina, P G Mbuthia, J Nguhiu-Mwangi, E G M Mogoa, W O Ogara
The objective of this study was to evaluate the gross and histo-pathological lesions caused by plastic bags in the rumen of sheep. Sixteen (16) castrated, one-year old Dorper sheep were used for the study. The animals were divided into 4 groups each consisting of 4 sheep. Three of the groups had 129 g, 258 g and 387 g of plastic bags, respectively, introduced into the rumen through rumenotomy, while the fourth group, without implants served as control. All the animals were observed daily for 6 weeks following implantation...
December 2017: International Journal of Veterinary Science and Medicine
Teck-Hui Teo, Fok-Moon Lum, Khairunnisa Ghaffar, Yi-Hao Chan, Siti Naqiah Amrun, Jeslin J L Tan, Cheryl Y P Lee, Tze-Kwang Chua, Guillaume Carissimo, Wendy W L Lee, Carla Claser, Ravisankar Rajarethinam, Laurent Rénia, Lisa F P Ng
Co-infection with Plasmodium and chikungunya virus (CHIKV) has been reported in humans, but the impact of co-infection on pathogenesis remains unclear. Here, we show that prior exposure to Plasmodium suppresses CHIKV-associated pathologies in mice. Mechanistically, Plasmodium infection induces IFNγ, which reduces viraemia of a subsequent CHIKV infection and suppresses tissue viral load and joint inflammation. Conversely, concomitant infection with both pathogens limits the peak of joint inflammation with no effect on CHIKV viraemia...
September 25, 2018: Nature Communications
Yujin Liu, Yalan Dong, Xiwen Zhu, Heng Fan, Meng Xu, Qianyun Chen, Zhen Nan, Hui Wu, Shuangjiao Deng, Xingxing Liu, Dongmei Zuo, Jia Yang
Th17 cells play an important role in the immune imbalance and inflammatory state in colonic mucosa of Inflammatory Bowel Disease (IBD) and to clarify the mechanism that affect the differentiation of Th17 cells will help us find a new target for the treatment of IBD. MiR-155 which is reported to have an important role in regulating immune system function is also detected to be significantly up-regulated in colonic tissues of IBD patients. However, whether and how miR-155 affects the differentiation of Th17 cells in the colon of IBD patients is still worth studying...
September 22, 2018: International Immunopharmacology
Jia He, Xinyi Zhao, Cheng Huang, Xiaoyun Zhou, Yan You, Lu Zhang, Chongmei Lu, Fang Yao, Shanqing Li
Inflammatory myofibroblastic tumor (IMT) is currently recognized as an intermediate mesenchymal neoplasm. It can arise anywhere in the body, but it is particularly common in the lungs. Gastric IMT is very rare in adults. In this study, we report a case of a 68-year-old woman with IMT in the gastric cardia, with invasion into the spleen and diaphragm. Because of its location and aggressive clinical features, it was first mistaken for gastric cancer. However, pathology and immunohistochemistry were used to finally confirm the diagnosis of IMT after total resection of the tumor and spleen and partial resection of the diaphragm...
September 25, 2018: Cancer Biology & Therapy
Qianjiang Ding, Zhihao Ren, Jianhua Wang, Xiaolong Ma, Jian Zhang, Gaofeng Sun, Changjing Zuo, Hao Gu, Hui Jiang
The aim of the present study was to evaluate the characteristics of computed tomography (CT) and magnetic resonance imaging (MRI), particularly diffusion-weighted imaging (DWI), in the imaging of intrapancreatic accessory spleen (IPAS). The clinical and pathological records of 9 patients, including 8 patients with IPAS and 1 patient with splenosis, were reviewed. The patients had undergone plain and triple-phase enhanced CT scanning (n=9) and MRI scanning (n=8). The lesions of the 8 IPAS patients were located in the pancreatic tail, and were round (n=3), oval (n=4) or triangular (n=1) in shape...
October 2018: Experimental and Therapeutic Medicine
M Scafi, S Valleix, A Benyamine, E Jean, J-R Harlé, P Rossi, L Daniel, N Schleinitz, B Granel
Lysozyme amyloidosis is a non-neuropathic hereditary amyloidosis identified in 1993. About fifty cases of this rare, probably under-diagnosed disease are reported. Lysozyme amyloidosis has a very broad spectrum of clinical manifestations. Sicca syndrome is often the first symptom, preceding the diagnosis by several years. Every part of the digestive tract can be involved with different grades of severity. The hallmark of this amyloidosis is the usually life-threatening spontaneous hepatic rupture. Renal involvement is frequent and progresses towards end-stage renal failure and dialysis...
September 20, 2018: La Revue de Médecine Interne
Shiqi Cao, Yi Geng, Zehui Yu, Longjun Deng, Weixiong Gan, Kaiyu Wang, Yangping Ou, Defang Chen, Xiaoli Huang, Zhicai Zuo, Min He, Weiming Lai
Acinetobacter lwoffii, a serious human pathogen, has been identified as a cause of nosocomial infections such as bacteremia, pneumonia and meningitis. There are only a few studies reporting A. lwoffii as a pathogen of fish. During 2016 and 2017, six bacterial strains, isolated from diseased fish of the Schizothorax genus, were identified as A. lwoffii by morphology, biochemical tests, 16S rDNA and gyrB gene sequencing analysis. One of these isolates was selected for experimental infection of Sclizothorax prenanti, Schizothorax davidi and Schizothorax wangchiachii, to confirm its pathogenicity...
September 21, 2018: Transboundary and Emerging Diseases
Yuji Nakamoto, Takayoshi Ishimori, Kohei Sano, Yoichi Shimizu, Kaori Togashi
OBJECTIVE: Positron emission tomography (PET)/computed tomography (CT) using 68 Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-D-Phe1 -Tyr3 -octreotide (DOTATOC) is usually performed about 1-h post-injection; however, because of rapid blood clearance, the waiting time for scanning could possibly be shortened without affecting diagnostic performance. The purpose of this study was to investigate the feasibility of early scanning at 30 min post-injection. METHODS: Thirty-eight patients who underwent DOTATOC-PET/CT were analyzed...
September 20, 2018: Annals of Nuclear Medicine
Marcos Isidoro-Ayza, Daniel A Grear, Aurélie Chambouvet
Severe Perkinsea infection (SPI) is an emerging disease of frogs responsible for mass mortalities of tadpoles across the United States. It is caused by protozoa belonging to the phylum Perkinsozoa that form a distinct group referred to as the Pathogenic Perkinsea Clade of frogs. In this work, we provide detailed description of gross and histologic lesions from 178 naturally infected tadpoles, including 10 species from 22 mortality events and 6 amphibian health monitoring studies from diverse geographic areas...
September 20, 2018: Veterinary Pathology
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