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Spleen Pathology

Yuan Tan, Yumeng Li, Yang Zhang, Jian Yu, Yating Wen, Chuan Wang, Man Xu, Qian Chen, Chunxue Lu, Yimou Wu
The present study evaluated the immune-protective efficacy of the Chlamydia psittaci (C. psittaci) plasmid protein CPSIT_p7 and analyzed the potential mechanisms of this protection. The current study used recombinant CPSIT_p7 protein with Freund's complete adjuvant and Freund's incomplete adjuvant to vaccinate BALB/c mice. Adjuvants alone or PBS formulated with the same adjuvants was used as negative controls. Mice were intranasally challenged with 105 inclusion-forming units (IFU) of C. psittaci. We found that CPSIT_p7 vaccination significantly decreased the mouse lung chlamydial load, interferon-γ (IFN-γ) level, and pathological injury...
August 10, 2018: Immunologic Research
So Yeong Cheon, Jeong Min Kim, Eun Jung Kim, So Yeon Kim, Eun Hee Kam, Chun-Chang Ho, Sang-Kyou Lee, Bon-Nyeo Koo
Patients undergoing surgery can suffer from various complications, including post-operative bleeding, local or systematic infection, and neurologic disorders. Major surgery can initiate innate immune responses and trigger overproduction of inflammatory mediators, which can contribute to organ dysfunction. Inflammasomes are innate immune complexes, which are connected to the pathogenesis of various diseases, including atherosclerosis, hemorrhagic brain injury, and Alzheimer's disease. In the present study, we hypothesized that nucleotide-binding oligomerization domain-containing-like receptor protein (NLRP) inflammasomes may have a role in the pathological effects of surgery...
August 7, 2018: Biochemical Pharmacology
Yuli Cheng, Xing Zhu, Xiaohuan Wang, Qinghui Zhuang, Xu Huyan, Ximeng Sun, Jingjing Huang, Bin Zhan, Xinping Zhu
Helminth infection induces Th2-biased immune responses and inhibitory/regulatory pathways that minimize excessive inflammation to facilitate the chronic infection of helminth in the host and in the meantime, prevent host hypersensitivity from autoimmune or atopic diseases. However, the detailed molecular mechanisms behind modulation on inflammatory diseases are yet to be clarified. Programmed death 1 (PD-1) is one of the important inhibitory receptors involved in the balance of host immune responses during chronic infection...
2018: Frontiers in Immunology
Lingling Qiu, Guobin Chang, Zhiteng Li, Yulin Bi, Xiangping Liu, Guohong Chen
Avian leukosis virus subgroup J (ALV-J) is an avian oncogenic retrovirus that induces myeloid tumors and hemangiomas in chickens and causes severe economic losses with commercial layer chickens and meat-type chickens. High-throughput sequencing followed by quantitative real-time polymerase chain reaction and bioinformatics analyses were performed to advance the understanding of regulatory networks associated with differentially expressed non-coding RNAs and mRNAs that facilitate ALV-J infection. We examined the expression of mRNAs, long non-coding RNAs (lncRNAs), and miRNAs in the spleens of 20-week-old chickens infected with ALV-J and uninfected chickens...
2018: Frontiers in Physiology
Christina Brandenberger, Katharina Maria Kling, Marius Vital, Mühlfeld Christian
Acute lung injury (ALI) is associated with increased morbidity and mortality in the elderly (> 65 years), but the knowledge about origin and effects of immunosenescence in ALI is limited. Here, we investigated the immune response at pulmonary, systemic and cellular level in young (2-3 months) and old (18-19 months) C57BL/6J mice to localize and characterize effects of immunosenescence in ALI. ALI was induced by intranasal lipopolysaccharide (LPS) application and the animals were sacrificed 24 or 72 h later...
August 2018: Aging and Disease
Ding-Bao Chen, Dan-Hua Shen, Shen-Miao Yang, Xin-Zhi Fang
BACKGROUND: To study the effects of splenectomy on treatment and diagnosis of tumours of lymphoid tissue of the spleen. METHODS: Fifty-three cases were reviewed from Peking University People's Hospital from 2002 to 2017. According to WHO classification of tumours of haematopoietic and lymphoid tissues (2008) and classification updated (2016), the cases were studied by microscopy, immunohistochemistry and in situ hybridization, combined with the bone marrow biopsy and clinical examination...
July 27, 2018: Pathology, Research and Practice
Matheus D Baldissera, Carine F Souza, Carla Cristina Zeppenfeld, Litiérri R Garzon, Sharine N Descovi, Aleksandro S Da Silva, Lenita M Stefani, Bernardo Baldisserotto
The spleen is an important secondary lymphatic organ that plays a key role in the immune and inflammatory responses of teleost fish. The purinergic signalling has been associated to these types of responses under pathological conditions by the regulation of extracellular adenosine triphosphate (ATP) and its metabolite adenosine (Ado), where both exert potent pro-inflammatory and anti-inflammatory profiles, respectively. The exact pathway involved on the immunotoxic effects of aflatoxin B1 (AFB1 ) in fish fed with diets containing this mycotoxin remains poorly understood...
August 4, 2018: Microbial Pathogenesis
Hui Zhang, Khalid Mehmood, Xiong Jiang, Wangyuan Yao, Mujahid Iqbal, Muhammad Waqas, Mujeeb Ur Rehman, Aoyun Li, Yaoqin Shen, Jiakui Li
Tetramethyl thiuram disulfide (thiram) is one of the important pesticides, which is extensively used in agriculture, but if it is combined with the cell membrane, then it causes membrane damage, bone morphogenic inactivation, and inhibited angiogenesis. Thiram has been considered a common cause of tibial dyschondrolplasia (TD) in various avian species, because it becomes the part of feed due to environmental contamination and its overuse in agriculture as pesticides or fungicide. However, there is no systematic study on the changes of the correlation indexes with toxic effect of the thiram in chickens...
August 3, 2018: Environmental Science and Pollution Research International
Chunhe Wan, Cuiteng Chen, Longfei Cheng, Guanghua Fu, Shaohua Shi, Rongchang Liu, Hongmei Chen, Qiuling Fu, Yu Huang
Recently, a novel pigeon adenovirus (N-PiAd) was found circulating in China, with the virus epidemiology and pathology remaining unclear. A TaqMan-based real-time PCR for detection and quantification of this newly identified N-PiAd infection targeting the hexon gene was developed with a limit of detection (LOD) of 31.2 DNA copies/μl, which was 10 times more sensitive than conventional PCR. There were no cross-reactions with common pigeon-origin viruses. Viral genome distribution in different tissues showed that the liver had the highest number of copies compared to other tissues (spleen, lung, kidney, heart and brain)...
July 31, 2018: Journal of Virological Methods
Seung Soo Kim, Jeong Ah Hwang, Hyeong Cheol Shin, Seo-Youn Choi, Tae Wook Kang, Sung Shick Jou, Woong Hee Lee, Suyeon Park, Nam Hun Heo
OBJECTIVES: To compare the sensitivity of Liver Imaging Reporting and Data System (LI-RADS) v2017 for diagnosis of hepatocellular carcinoma (HCC) using multiphasic computed tomography (CT) between patients with and without moderate to severe fatty liver (MSFL). METHODS: This retrospective study included a total of 106 high-risk patients with 112 pathologically proven HCCs who underwent multiphasic CT. Patients were classified as MSFL (24 men, 2 women; mean age, 59...
August 2, 2018: European Radiology
Danni Yohani Santana, Rafael Moysés Salgado, Marina Fevereiro, Rogério Silva do Nascimento, Raissa Fonseca, Niels Olsen Saraiva Câmara, Sabrina Epiphanio, Cláudio Romero Farias Marinho, Maria Luiza Barreto-Chaves, Maria Regina D' Império-Lima, José M Álvarez
Cardiomyopathy is the most serious consequence of Chagas disease, a neglected human disorder caused by Trypanosoma cruzi infection. Because T. cruzi parasites invade cardiomyocytes, we sought to investigate whether these cells recognize the parasite in vivo by receptors signaling through the MyD88 adaptor, which mediates the activation pathway of most Toll-like receptors (TLRs) and IL-1/IL-18 receptors, and influence the development of acute cardiac pathology. First, we showed that HL-1 cardiac muscle cell line expresses MyD88 gene and protein at resting state and after T...
August 1, 2018: PLoS Neglected Tropical Diseases
Jyoti Patel, Gillian Douglas, Alastair G Kerr, Ashley B Hale, Keith M Channon
BACKGROUND AND AIMS: Angiotensin II (Ang II) infusion promotes the development of aortic aneurysms and accelerates atherosclerosis in ApoE-/- mice. In order to elucidate the role of hematopoietic cells in these pathologies, irradiation and bone marrow transplantation (BMT) are commonly utilized. The aim of this study was to investigate the effects of irradiation and BMT on abdominal and thoracic aortic aneurysm formation and acute leukocyte recruitment in the aortic root and descending aorta, in an experimental mouse model of aortic aneurysm formation...
July 23, 2018: Atherosclerosis
Godfrey A Dzhivhuho, Samantha A Rehrl, Hlumani Ndlovu, William G C Horsnell, Frank Brombacher, Anna-Lise Williamson, Gerald K Chege
Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that may impair HIV vaccine-generated Th1 responses. In this study, we tested if Schistosoma mansoni (Sm) infection altered immune responses to SAAVI candidate HIV vaccines (DNA and MVA) and an HIV-1 gp140 Env protein vaccine (gp140) and whether parasite elimination by chemotherapy or the presence of Sm eggs (SmE) in the absence of active infection influenced the immunogenicity of these vaccines...
July 26, 2018: PLoS Pathogens
Qiufang Deng, Ting Zhao, Baihong Pan, Isabel S Dennahy, Xiuzhen Duan, Aaron M Williams, Baoling Liu, Nan Lin, Umar F Bhatti, Eric Chen, Hasan B Alam, Yongqing Li
We have found earlier that Tubastatin A (TubA), a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival in a mouse model of lethal cecal ligation and puncture (CLP)-induced sepsis. However, the underlying mechanisms have not been fully established. This study sought to test the hypothesis that TubA could affect both lung and splenic functions. C57BL/6J mice were subjected to CLP, and randomized to receive either TubA (70 mg/kg) dissolved in dimethyl sulfoxide (DMSO), or DMSO alone, 1 h following CLP...
July 26, 2018: Inflammation
F Dai, X Xiang, G Duan, B Duan, X Xiao, H Chang
The death of several black bears at the black bear breeding base in Yunnan Pingbian Daweishan is a matter of concern. Multiple black bears exhibited decreased appetite or unusual waste, and some were soporific or suffered from vomiting and anhelation. In order to ascertain the cause of death, 16S rDNA gene sequencing and phylogenetic analysis was performed on bacteria isolated from tissue samples obtained from dead bears. The biochemical characteristics of the isolated bacteria were subsequently analyzed using different biochemical test systems...
2018: Iranian Journal of Veterinary Research
Khalid Elfaki Ibrahim, Mohsen Ghaleb Al-Mutary, Amel Omer Bakhiet, Haseeb Ahmad Khan
Gold nanoparticles (GNPs) are biocompatible nanomaterials that are currently researched for biomedical applications such as imaging and targeted drug delivery. In this investigation, we studied the effects of a single dose (injected on day 1) as well as a priming dose (two injections with a gap of one week) of 5 nm, 20 nm, and 50 nm diameter GNPs on the structural and biochemical changes in the liver, kidney, and spleen of mice. The results showed that small sized GNPs (5 nm) produced significant pathological changes in the liver on day 2 that gradually reduced on day 8...
July 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Qiuting Cao, Shufan Shang, Xinjun Han, Di Cao, Liqin Zhao
RATIONALE AND OBJECTIVES: To investigate the value of using rapid kVp switching dual energy computed tomography (rsDECT) for the multi-parameter analysis of the heterogeneity of fatty liver in rat. MATERIALS AND METHODS: Twenty-four male rats were randomly divided into experimental (n = 16) and control (n = 8) groups. Four rats in the experimental group and two in the control group were examined by rsDECT every 3 weeks starting from week 8. The liver fat contents (LFC) of the left and right liver lobes were measured on the fat(water)-based material decomposition images to calculate fat content and CT value of liver and spleen were measured on the 70keV monochromatic images to calculate the liver-to-spleen CT value ratio [(L/S)70 keV ] and difference at 70keV[(L-S)70 keV ], and the spectral curve slopes of the left and right liver lobes (Slope-L, Slope-R)...
July 2, 2018: Academic Radiology
Xiao-Juan Dai, Jin-Hui Tao, Xuan Fang, Yuan Xia, Xiao-Mei Li, Yi-Ping Wang, Xiang-Pei Li
Acute gouty arthritis is the inflammation of joint tissues in the acute form due to the deposition of monosodium urate (MSU) crystals. Regulatory T cells (Tregs) and Th17 cells play an important role in the development and progression of inflammatory diseases. However, the expression and role of Tregs and Th17 cells are not clear in this disease. Here, we investigated the changes of Tregs, Th17 cells, and Treg/Th17 ratio in spleen, as well as the inflammatory cytokines in blood and joint tissue pathology in acute gouty arthritis rat induced by MSU...
July 23, 2018: Inflammation
W W Jin, C Lu, Y P Mou, X W Xu, R C Zhang, Y C Zhou, Z Y Qian, C J Huang
Objective: To evaluate the safety and feasible of adjacent organ resection during laparoscopic pancreaticoduodenectomy(LPD), and summary the surgical strategies. Methods: Clinical data of 15 adjacent organ resections combined with LPD from March 2013 to September 2017 were reviewed.There were 10 male and 5 female patients aging from 20 to 86 years, and the body mass index ranged from 19.6 to 34.5 kg/m(2).Two patients had previous abdominal surgical history.Two patients underwent preoperative chemotherapy. Results: The resected adjacent organs included liver( n =4), stomach( n =3), colon( n =6), right kidney with embolectomy and vasoplastic of inferior vena cava( n =1), and spleen artery aneurysms( n =1)...
July 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Shohei Iijima, Tomohiro Chiba, Keisuke Maruyama, Kuniaki Saito, Keiichi Kobayashi, Yuki Yamagishi, Junji Shibahara, Nobuyuki Takayama, Yoshiaki Shiokawa, Motoo Nagane
BACKGROUND: Brain involvement of hepatosplenic T-cell lymphoma (HSTL) has not been reported so far. CASE DESCRIPTION: We experienced an extremely rare case of HSTL, which is a rare and aggressive variant of peripheral T-cell lymphoma, generally showing predominant infiltration to the liver, spleen and bone marrow, involving the brain. A 41-year-old Japanese female patient presented with dysarthria and numbness of the right hand. Radiological examination revealed a single 3 cm mass in the left frontal cortex, which was totally removed...
July 17, 2018: World Neurosurgery
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