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Spleen Pathology

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https://www.readbyqxmd.com/read/30534841/the-importance-of-the-histopathological-examination-in-lethal-acute-intoxication-with-ethylene-glycol-case-report
#1
Claudia Teodora Judea-Pusta, Gabriela Muţiu, Andrei Vasile Paşcalău, Camelia Liana Buhaş, Adina Nicoleta Ciursaş, Carmen Delia Nistor-Cseppento, Alina Bodea, Adrian Sorin Judea, Răzvan Marius Vicaş, Luciana Dobjanschi, Ovidiu Laurean Pop
Ethylene glycol is a toxic alcohol that is mainly introduced into an organism through the digestive pathway. Its priority toxic metabolites are glycolic acid and oxalic acid. We present the case of a young person, of the male persuasion, without any personal pathological history, found unconscious and presenting signs of violence. The patient is emergency hospitalized presenting coma, convulsive syndrome, severe metabolic acidosis and a positive result for alcoholism. Anamnestic data is extremely poor. The results of the clinical and paraclinical examinations suggest a possible poisoning with toxic alcohols...
2018: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/30532215/clinical-utility-of-fdg-uptake-within-reticuloendothelial-system-on-f-18-fdg-pet-ct-for-prediction-of-tumor-recurrence-in-breast-cancer
#2
Ji-In Bang, Hai-Jeon Yoon, Bom Sahn Kim
BACKGROUND: The aim of this study was to investigate the metabolism of the spleen, bone marrow (BM), and liver from preoperative F-18 FDG PET/CT scans for the prediction of recurrence in breast cancer. METHODS: We retrospectively included 153 patients diagnosed with invasive ductal carcinoma (IDC) of the breast who underwent preoperative F-18 FDG PET/CT scan and a curative operation. The mean standardized uptake value (SUVmean) of the spleen, liver, and BM and maximum SUV (SUVmax) of primary tumors were measured...
2018: PloS One
https://www.readbyqxmd.com/read/30524689/camel-whey-protein-enhances-lymphocyte-survival-by-modulating-the-expression-of-survivin-bim-bax-and-cytochrome-c-and-restores-heat-stress-mediated-pathological-alteration-in-lymphoid-organs
#3
Nancy K Ramadan, Gamal Badr, Hanem S Abdel-Tawab, Samia F Ahmed, Mohamed H Mahmoud
Objectives: Heat stress (HS) is a catastrophic stressor that dampens immunity. The current study investigates the effect of dietary administration with camel whey protein (CWP) on apoptotic pathway caused by HS. Materials and Methods: Forty-five male mice were divided into three groups: a control group; HS group; and HS mice that were orally supplemented with CWP (CWP-HS group). Results: We found that reactive oxygen species (ROS), pro-inflammatory cytokines (IL-6), and C reactive protein (CRP) were elevated in the HS group along with a significant increase of caspase-9 and -3 and decrease of total antioxidant capacity (TAC)...
September 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30522016/er-shen-wan-extract-alleviates-polyuria-and-regulates-aqp-2-and-avpr-2-in-a-rat-model-of-spleen-kidney-yang-deficiency-induced-diarrhea
#4
Rui Xiong, Yidan Li, Kaixuan Zheng, Tingting Zhang, Mingyang Gao, Yun Li, Yumei Lian, Da Chen, Changjiang Hu
ETHNOPHARMACOLOGICAL RELEVANCE: Er Shen Wan (ESW), has been empirically used for treating spleen-kidney Yang deficiency (SKYD) syndrome in Traditional Chinese medicine (TCM) for centuries and shows a variety of activities. The medicinal formula is a mixture of two component herbs, Psoraleae Fructus (PF, Bu-Gu-Zhi in Chinese) and Myristicae Semen (MS, Rou-Dou-Kou in Chinese). The current study was designed to evaluate ESWP antidiuretic treatment of polyuria and to explore potential mechanisms of renal water metabolism in the rat model of SKYD-induced diarrhea...
December 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30513383/different-responses-in-one-year-old-and-three-year-old-grass-carp-reveal-the-mechanism-of-age-restriction-of-gcrv-infection
#5
Geng Chen, Lv Xiong, Yumeng Wang, Libo He, Rong Huang, Lanjie Liao, Zuoyan Zhu, Yaping Wang
Grass carp is an important fish species in Chinese aquaculture, and can be afflicted by a hemorrhagic disease caused by the grass carp reovirus (GCRV). Interestingly, the affects of GCRV infection of grass carp are age-restricted, meaning that one-year-old grass carp can be infected and can suffer hemorrhagic disease, but three-year-old carp are not so afflicted. In this study, we investigated the mechanism responsible for this age-restricted pathology. We evaluated the relative copy number of GCRV RNA, the expression levels of proteins in blood, and changes in DNA methylation in carp from the two age groups after infection with GCRV...
December 1, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/30511904/the-reparative-effects-of-human-adipose-derived-mesenchymal-stem-cells-in-the-chemotherapy-damaged-thymus
#6
Ying Zhan, Lihua Wang, Guangyang Liu, Xiaohui Zhang, Jingci Yang, Yuxia Pan, Jianmin Luo
Hematological patients who accept chemotherapy always develop secondary tumor or even die of severe infections. As an important central lymphoid organ, the thymus is frequently damaged during chemotherapy. Previous studies showed that the mesenchymal stem cells (MSCs) can promote the proliferation and repair of epithelial cells in thymus. The purpose of our study is to investigate the reparative effects of human adipose-derived mesenchymal stem cells (hADMSCs) for chemotherapy treated damaged thymus. 80 mice were randomly divided into four groups: normal group, model control group, hADMSCs untreated group and hADMSCs treated group...
December 4, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/30510634/coexistence-of-duodenum-derived-aggressive-fibromatosis-and-paraduodenal-hydatid-cyst-a-case-report-and-review-of-literature
#7
Sami Akbulut, Mehmet Yilmaz, Saadet Alan, Mehmet Kolu, Nese Karadag
Intra-abdominal aggressive fibromatosis is a locally aggressive tumor mostly originating from the mesentery or retroperitoneal space, infiltrating adjacent tissues, and very rarely metastasizing to distant organs. There are only two case reports in the English language literature where intra-abdominal aggressive fibromatosis originated from the intestinal wall. In this study, we aimed to report a case of aggressive fibromatosis originating from the muscularis propria layer of the duodenum and invading pancreas...
November 27, 2018: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30510633/male-gender-and-increased-body-mass-index-independently-predicts-clinically-relevant-morbidity-after-spleen-preserving-distal-pancreatectomy
#8
Traian Dumitrascu, Mihai Eftimie, Andra Aiordachioae, Cezar Stroescu, Simona Dima, Mihnea Ionescu, Irinel Popescu
AIM: To identify risk factors for clinically relevant complications after spleen-preserving distal pancreatectomy (SPDP). No previous studies explored potential predictors of morbidity after SPDP. METHODS: The data of 41 patients who underwent a SPDP in a single surgical center between 2000 and 2015 were retrospectively reviewed from a prospectively maintained electronic database established in our Department of Surgery. The database included demographic, clinical, bioumoral, pathological, intraoperative and postoperative parameters...
November 27, 2018: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30510488/regulatory-role-of-rno-mir-30b-5p-in-il-10-and-toll-like-receptor-4-expressions-of-t-lymphocytes-in-experimental-autoimmune-uveitis-in-vitro
#9
Yuanyuan Sun, Dadong Guo, Bin Liu, Xuewei Yin, Huixia Wei, Kai Tang, Hongsheng Bi
Uveitis is a serious eye disease that usually damages young adult's health. MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate messenger RNA (mRNA) expression. It is predicted that rno-miR-30b-5p can regulate the expressions of interleukin-10 (IL-10) and Toll-like receptor 4 (TLR4). In this study, the regulatory role of rno-miR-30b-5p in IL-10 and TLR4 gene expressions was validated using luciferase activity assay. Further, the inflammatory manifestation of the anterior segment and pathological examination of the eye were explored in experimental autoimmune uveitis (EAU) rats...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/30505440/a-giant-splenic-hamartoma-associated-with-hematologic-disorders-a-case-report
#10
Mauricio Gonzalez Urquijo, Mario Rodarte-Shade, Raul Rangel-Rangel, Jorge A Castillo-Meraz, Jaime R Rodriguez-Tejeda, Gerardo Gil-Galindo
Introduction: Splenic hamartoma is a primary benign tumor of the spleen, with approximately 150 cases documented in the literature to date, with only a few cases associated with symptoms and hematologic disorders. Presentation of case: A 49-year-old female with no past medical history, presented to the emergency department complaining of a three-month history of intermittent abdominal pain and 12 kg of weight loss. Physical examination revealed abdominal distension and a big palpable and painless mass on the left side of her abdomen measuring 14 cm...
December 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/30501742/toxicity-of-two-different-size-ceria-nanoparticles-to-mice-after-repeated-intranasal-instillation
#11
Juanjuan Wu, Yuhui Ma, Yayun Ding, Peng Zhang, Xiao He, Zhiyong Zhang
Ceria nanoparticles (nanoceria) have been used as a fuel-borne catalyst, and are emitted in the particulate phase in the diesel exhaust. To evaluate the potential health risks of airborne nanoceria, the pulmonary and systemic consequences of nanoceria to ICR mice were studied under repeated transnasal instillation. Two different size nanoceria (7-nm and 25-nm) were chose, representing the nanoceria mostly used as fuel additives and the combustion products of the very nanoceria, respectively. As the first target organ of nanoceria, the lungs suffered serious damages manifested in the results of their biochemical and pathological examinations...
May 1, 2019: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/30500936/vaccination-of-guinea-pigs-with-bcg%C3%AE-bcg1419c-transiently-reduces-hematogenous-spread-of-m-tuberculosis-to-the-spleen
#12
Michel de Jesús Aceves-Sánchez, Crystal Shanley, Ian Orme, Helle Bielefeldt-Ohmann, Mario Alberto Flores-Valdez
The guinea pig has proven to be a reliable model for testing of vaccine candidates against tuberculosis (TB) because of its capacity to produce human-like disease associated to primary TB, thus providing a more stringent test of the ability of a vaccine to prevent disease and deaths. Here, the BCGΔBCG1419c vaccine candidate, which previously has been shown to provide protection in mice, was tested in a guinea pig model. We found that this vaccine candidate was as effective as parental BCG in reducing M. tuberculosis H37Rv replication in lungs, and significantly reducing hematogenous spread to spleen at 60 days post-infection in comparison to BCG...
November 30, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/30488805/biodistribution-safety-and-organ-toxicity-of-docetaxel-loaded-in-her-2-aptamer-conjugated-ecoflex%C3%A2-nanoparticles-in-a-mouse-xenograft-model-of-ovarian-cancer
#13
Erfaneh Ghassami, Jaleh Varshosaz, Mohsen Minaiyan, Mehrab Nasirikenari, Seyed Mohammad Hoseini
BACKGROUND: Docetaxel is a notably efficient anticancer drug administered for several types of malignancies including ovarian cancer. However, various side effects caused either by nonspecific distribution of the active ingredient or by high contents of Tween 80 and ethanol in the currently marketed formulations, could even deprive the patients of the treatment. OBJECTIVES: In the current study, a novel targeted delivery system composed of Ecoflex® polymeric nanoparticles loaded with docetaxel and equipped with HER-2 specific aptemer molecules were evaluated regarding blood and tissue toxicity, and biodistribution...
November 28, 2018: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/30487514/role-of-immune-cells-and-cytokines-for-immune-response-in-kala-azar
#14
S R Sarkar, N C Ray, S Nahar, S Roy, M A Aziz, A M Al Amin, S K Paul
Resolution of leishmanial infection is dependent on the coordinated interactions between components of cell mediated immune response, central to which is the activation of targeted T-cell populations for appropriate cytokine production and activation of infected cells. There is a correlation between the clinical outcome of Leishmania infection and the cytokine response profile. While a protective immune response against Leishmania has been clearly identified to be related to the influence of a type-l response and IFN-γ production, the precise role of T helper (TH) 2 cytokines in non-healing infections requires further exploration...
October 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/30487279/induction-of-porcine-dermatitis-and-nephropathy-syndrome-in-piglets-by-infection-with-porcine-circovirus-type-3
#15
Haijun Jiang, Dan Wang, Jing Wang, Shanshan Zhu, Ruiping She, Xinxin Ren, Jijing Tian, Rong Quan, Lei Hou, Zixuan Li, Jun Chu, Yuxin Guo, Yanyang Xi, Huiqi Song, Feng Yuan, Li Wei, Jue Liu
Porcine circovirus type 3 (PCV3) is an emerging porcine circovirus that has been associated with porcine dermatitis and nephropathy syndrome (PDNS)-like clinical signs, reproductive failure, cardiac pathologies and multisystemic inflammation in piglets and sows. Many aspects of PCV3 infection biology and pathogenesis, however, remain unknown. Here, we used a PCV3 virus stock from rescue of an infectious PCV3 DNA clone to intranasally inoculate 4- and 8-week-old specific-pathogen-free piglets for evaluation of PCV3 pathogenesis...
November 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30482035/laparoscopic-hemi-splenectomy-a-valid-option-in-selected-cases-such-as-epidermoid-cyst
#16
F J Tejero-Pintor, C Cuesta-De la Llave, M Rodriguez-Lopez, M Bailon-Cuadrado, D Pacheco-Sánchez
Splenic cysts are a rare pathology, which can be classified as true (25%) or pseudocysts (75%). Total splenectomy has been the treatment of choice, particularly in recent times with the advent of the laparoscopic approach. However, as the spleen is an organ with multiple immunological functions, the laparoscopic partial splenectomy is an alternative, which is technically difficult but effective. We present a case of a 26-year-old woman with incidental evidence of a splenic cyst in an abdominal ultrasound scan...
November 28, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/30476621/a-novel-experimental-intraperitoneal-infection-model-for-haemophilus-parasuis-in-neutropenic-guinea-pigs
#17
Yong-da Zhao, Bao-Tao Liu, Li-Li Guo, Hu Shan, Bing-Hu Fang
INTRODUCTION: Haemophilus parasuis, one of the major swine pathogens, has at least fifteen different types, all of which have significant economic effects on the global swine industry. The aim of this study was to establish an experimental intraperitoneal infection model for H. parasuis in neutropenic guinea pigs. METHODS: Intraperitoneal administration of cyclophosphamide and Haemophilus parasuis was conducted in guinea pigs. Clinical signs, gross pathology, and histopathology were observed in neutropenic guinea pigs infected with H...
November 23, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/30468505/the-low-protein-diet-affects-the-nonspecific-inflammatory-response-of-middle-aged-and-old-mice-through-mtor
#18
J-H Guo, H-Y Wang, Q Zhang, M Feng, L-J Zhang
OBJECTIVE: To explore the effect of low protein diet on nonspecific inflammatory changes in mice during aging and related mechanisms. MATERIALS AND METHODS: Thirty-two 14-month-old female KM mice were randomly divided into 4 groups: control group, low protein group, high protein group, high protein + rapamycin group. Hematoxylin-eosin (HE) staining was performed to observe the pathological changes of the liver. Immunohistochemistry of liver sections was performed to detect the expression of CD68 protein...
November 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30468295/touch-imprint-ti-cytology-of-needle-core-biopsies-ncb-in-pathology-laboratories-a-practice-survey-of-participants-in-the-college-of-american-pathologists-cap-non-gynecologic-cytopathology-ngc-education-program
#19
Vijayalakshmi Padmanabhan, Güliz A Barkan, Laura Tabatabai, Rhona Souers, Ritu Nayar, Barbara A Crothers
BACKGROUND: Intra-procedural assessment of touch imprint (TI) cytology from needle core biopsies (NCB) is used to ensure sample adequacy and to provide immediate diagnosis in various settings. We aimed to survey laboratories for current practices on the use of cytology with NCB. METHODS: A voluntary supplemental questionnaire including questions on demographics, personnel involved, sites, accessioning, and reporting was sent with the College of American Pathologists (CAP) 2015 Non gynecologic Cytopathology Education Program to survey practices of cytologic assessment of NCB...
November 23, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/30465345/-impacts-of-periodontitis-on-visceral-organ-weight-and-weight-percentage-in-obese-mice
#20
Ting Yu, Li Zhao, Jin-Cai Zhang, Dong-Ying Xuan
OBJECTIVE: This study aimed to explore the impacts of periodontitis on the visceral weight and weight percentage of obese animal models. METHODS: A total of 64 C57BL/6J mice were divided into the following diet groups: high-fat diet (HFD) group (n=36), which was fed with high-fat diet to induce obesity, and low-fat diet (LFD) group (n=28), which was fed with low-fat diet as the control. After 16 weeks on diet, each diet group was divided into periodontitis (P) and control (C) groups...
October 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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