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Predictors of AKI

Raymond K Hsu, Jonathon D Truwit, Michael A Matthay, Joseph E Levitt, Boyd Taylor Thompson, Kathleen D Liu
Background: Acute kidney injury (AKI) commonly occurs in patients with sepsis and acute respiratory distress syndrome (ARDS). Objective: To investigate whether statin treatment is protective against AKI in sepsis-associated ARDS. Design: Secondary analysis of data from Statins for Acutely Injured Lungs in Sepsis (SAILS), a randomized controlled trial that tested the impact of rosuvastatin therapy on mortality in patients with sepsis-associated ARDS...
2018: Canadian Journal of Kidney Health and Disease
Daniele Roberto Giacobbe, Alessandra di Masi, Loris Leboffe, Valerio Del Bono, Marianna Rossi, Dario Cappiello, Erika Coppo, Anna Marchese, Annarita Casulli, Alessio Signori, Andrea Novelli, Katja Perrone, Luigi Principe, Alessandra Bandera, Luca Enrico Vender, Andrea Misin, Pierpaolo Occhilupo, Marcello Melone, Paolo Ascenzi, Andrea Gori, Roberto Luzzati, Claudio Viscoli, Stefano Di Bella
This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin...
August 10, 2018: Scientific Reports
Daniela Cardinale, Nicola Cosentino, Marco Moltrasio, Maria Teresa Sandri, Francesco Petrella, Alessandro Colombo, Giulia Bacchiani, Adele Tessitore, Alice Bonomi, Fabrizio Veglia, Michela Salvatici, Carlo M Cipolla, Giancarlo Marenzi, Lorenzo Spaggiari
BACKGROUND: Acute kidney injury (AKI) frequently occurs in several medical and surgical settings, and it is associated with increased morbidity and mortality. In patients undergoing lung cancer surgery, AKI has not been fully investigated. We prospectively evaluated the incidence, clinical relevance, and risk factors of AKI in patients undergoing lung cancer surgery. Moreover, we estimated the accuracy of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the prediction of AKI. METHODS: Patients undergoing lung cancer surgery were included in the study...
September 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Wei-Yoon Poh, Marhanis Salihah Omar, Hwee-Pheng Tan
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is rec.ognized as a common complication of radiographic contrast-enhanced procedures. N-acetylcysteine (NAC) is commonly prescribed, but CI-AKI can still develop despite NAC administration as prophylaxis. OBJECTIVE: Identify the predictive factors for development of CI-AKI in patients prescribed NAC. DESIGN: Prospective, cross-sectional. SETTING: A tertiary hospital in Malaysia...
July 2018: Annals of Saudi Medicine
Jinhong Li, Ying Tang, Patrick M K Tang, Jun Lv, Xiao-Ru Huang, Christine Carlsson-Skwirut, Lydie Da Costa, Anna Aspesi, Suada Fröhlich, Pawel Szczęśniak, Philipp Lacher, Jörg Klug, Andreas Meinhardt, Günter Fingerle-Rowson, Rujun Gong, Zhihua Zheng, Anping Xu, Hui-Yao Lan
Macrophage migration inhibitory factor (MIF) is elevated in patients with acute kidney injury (AKI) and is suggested as a potential predictor for renal replacement therapy in AKI. In this study, we found that MIF also plays a pathogenic role and is a therapeutic target for AKI. In a cisplatin-induced AKI mouse model, elevated plasma MIF correlated with increased serum creatinine and the severity of renal inflammation and tubular necrosis, whereas deletion of MIF protected the kidney from cisplatin-induced AKI by largely improving renal functional and histological injury, and suppressing renal inflammation including upregulation of cytokines such as interleukin (IL)-1β, tumor necrosis factor-alpha (TNF-α), IL-6, inducible nitric oxide synthase (iNOS), MCP-1, IL-8, and infiltration of macrophages, neutrophils, and T cells...
July 17, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Sandro Ninni, Claire Seunes, Staniel Ortmans, Stéphanie Mouton, Thomas Modine, Mohamed Koussa, Bruno Jegou, Jean-Louis Edme, Bart Staels, David Montaigne, Augustin Coisne
BACKGROUND: A relevant morning-afternoon variation in ischemia-reperfusion (IR) insult after cardiac surgery has been demonstrated. We speculated that the biorhythm might also impact systemic reactions involved in acute kidney injury (AKI) following cardiac surgery. We aimed at investigating incidence, determinants and prognostic impact of AKI in a large cohort of patients referred for surgical aortic valve replacement (SAVR) according to surgery time-of-day. METHODS: Between 2009 and 2015, we explored consecutive patients referred to our Heart Valve Center (CHU Lille) for first SAVR...
July 19, 2018: International Journal of Cardiology
Helmut Schiffl
INTRODUCTION: Severe acute kidney injury (AKI-D) is common in critically ill patients and contributes substantially to short- and long-term morbidity and mortality. Acute renal replacement therapy (RRT) is an increasingly widely utilized life-sustaining support strategy for AKI-D patients, providing a bridge to renal recovery in many survivors of AKI. However, key aspects (when and how) of this therapy's appropriate cessation remain unclear. Today, wide variation in clinical practice exists regarding the indication for and the timing of RTT discontinuation, likely due to the poor current evidence base...
August 2, 2018: International Urology and Nephrology
Jayakumar Sreenivasan, Min Zhuo, Muhammad Shahzeb Khan, Heyi Li, Setri Fugar, Parth Desai, Neha Yadav
Contrast-induced acute kidney injury (CI-AKI) following coronary angiography is associated with increased mortality. The association between severity of anemia and CI-AKI following coronary angiography is not well-established. In this retrospective study, we aimed at assessing the association of anemia of various severity with the risk of CI-AKI in patients who underwent coronary angiography. We included all patients who underwent coronary angiography with or without percutaneous coronary intervention from January 2012 to December 2016 at a single tertiary care hospital...
June 22, 2018: American Journal of Cardiology
Tae Hyung Kim, Han Ah Lee, Yeon Seok Seo, Yoo Ra Lee, Sun Young Yim, Young Sun Lee, Sang Jun Suh, Young Kul Jung, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon Ho Um
BACKGROUND & AIMS: For appropriate management of acute kidney injury (AKI) in cirrhotic patients, accurate differentiation of the types of AKI, prerenal azotemia (PRA), hepatorenal syndrome (HRS) and acute tubular necrosis (ATN) is very important. Urine N-acetyl-β-D-glucosaminidase (NAG) has been proposed as a good tubular injury marker in many studies, but its efficacy in cirrhosis is unclear. This study was performed to evaluate the usefulness of urine NAG in patients with decompensated cirrhosis...
July 30, 2018: Journal of Gastroenterology and Hepatology
Małgorzata Zalewska-Adamiec, Jolanta Małyszko, Hanna Bachórzewska-Gajewska, Anna Tomaszuk-Kazberuk, Marcin Kożuch, Paweł Kralisz, Sławomir Dobrzycki
Introduction The prognosis of takotsubo syndrome -TTS was recognized as benign, however, in takotsubo patients with chronic kidney disease (CKD), severe complications in the acute phase of the disease, mainly, sudden cardiac arrest are more common. Objectives The aim of the study was to assess the impact of CKD on early and long-term outcomes, including mortality among 95 patients with TTS. Patients and methods All the patients underwent coronary angiography. Clinical, biochemical and other medical data were recorded...
July 27, 2018: Polish Archives of Internal Medicine
Andrea B V Silva, Agueda Maria Ruiz Zimmer Cavalcante, Fabio P Taniguchi
OBJECTIVE: Acute kidney injury (AKI) is a frequent postoperative complication after cardiovascular surgery. It has been described as a predictor of decreased survival rates, but how dialysis decreases survival when initiated on the postoperative period has yet to be determined. To analyze the survival of patients who presented postoperative AKI requiring dialysis up to 30 days after cardiovascular surgery and its risk factors is the aim of this study. METHODS: Of the 5,189 cardiovascular surgeries performed in a 4-year period, 157 patients developed AKI requiring dialysis in the postoperative period...
May 2018: Brazilian Journal of Cardiovascular Surgery
Hakan Parlar, Hüseyin Şaşkın
OBJECTIVE: In this study, we investigated the role of two of the recent biomarkers of inflammation on the development of acute kidney injury in the early postoperative period of isolated coronary artery bypass grafting. METHODS: Three hundred and eleven patients, who underwent isolated coronary artery bypass grafting with cardiopulmonary bypass by the same surgery team in our clinic between May 2010 and October 2014, who had a preoperative serum creatinine level lower than 1...
May 2018: Brazilian Journal of Cardiovascular Surgery
Claire Triffault-Fillit, Florent Valour, Ronan Guillo, Michel Tod, Sylvain Goutelle, Sébastien Lustig, Michel-Henry Fessy, Christian Chidiac, Tristan Ferry
Objectives: The empirical use of vancomycin in combination with a broad-spectrum betalactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. Patient and methods: Adult patients receiving an empirical antimicrobial therapy (EAT) for a PJI were enrolled in a prospective cohort study (2011-2016). EAT-related adverse events (AE) were described according to the common terminology criteria for AE (CTCAE), and their determinants were assessed by logistic regression and Kaplan-Meier curve analysis...
July 23, 2018: Antimicrobial Agents and Chemotherapy
Joseph Zabell, Sudhir Isharwal, Wen Dong, Joseph Abraham, Jitao Wu, Chalairat Suk-Ouichai, Diego Aguilar Palacios, Erick Remer, Jianbo Li, Steven C Campbell
PURPOSE: Acute kidney injury (AKI) often leads to chronic kidney disease (CKD) in the general population. The long-term functional impact of AKI observed after partial nephrectomy (PN) has not been adequately studied. MATERIALS AND METHODS: From 2004-2014, 90 solitary kidneys managed with PN had necessary studies for analysis including functional data at 4 time points: pre-operative, peak serum creatinine (SCr) post-surgery, new baseline SCr (3-12 months post-operatively), and long-term follow-up SCr (>12 months post-operatively)...
July 20, 2018: Journal of Urology
D Li, J Yu, Z Han, Z Cheng, F Liu, J Dou, P Liang
AIM: To explore the risk factors predicting haemoglobinuria after ultrasound-guided percutaneous microwave ablation (MWA) of liver tumours and discuss the treatments and outcomes. MATERIALS AND METHODS: The present study comprised 2,829 patients admitted for liver tumours treated with MWA from Jan 2011 to April 2017. Ethics committee approval was waived and informed consent for treatment procedures were obtained from the patients. Haemoglobinuria after MWA was found in 149 patients...
July 17, 2018: Clinical Radiology
Omri Nativ, Zaher Bahouth, Edmond Sabo, Sarel Halachmi, Boaz Moskovitz, Elias G Hellou, Zaid Abassi, Ofer Nativ
INTRODUCTION: The aim of our study was to examine the influence of tumor complexity and operative variables on the degree and rate of post-nephron sparing surgery (NSS) acute kidney injury (AKI). METHODS: We retrospectively reviewed the records of 477 patients who underwent NSS for enhancing renal masses in our institution. AKI was determined using the latest definition by AKIN and RIFLE criteria. Serum creatinine was assessed daily starting from day 1 post-surgery and until discharge (usually on postoperative day 3)...
July 19, 2018: Urologia Internationalis
Hideya Yamamoto, Yasuki Kihara, Toshiro Kitagawa, Norihiko Ohashi, Eiji Kunita, Yoshitaka Iwanaga, Kazuhiro Kobuke, Shunichi Miyazaki, Tomohiro Kawasaki, Shinichiro Fujimoto, Hiroyuki Daida, Takashi Fujii, Aki Sato, Tomokazu Okimoto, Sachio Kuribayashi
BACKGROUND: Coronary computed tomography angiography (CCTA) not only provides information regarding luminal stenoses but also allows for visualization of mural atheromatous changes (coronary plaques). OBJECTIVE: We sought to elucidate whether plaques seen on CCTA enable prediction of 2-year outcomes in patients with suspected and known coronary artery disease (CAD). METHODS: Of 3015 patients who underwent CCTA, the images and 2-year clinical courses of 2802 patients were independently analyzed...
July 7, 2018: Journal of Cardiovascular Computed Tomography
A Young Cho, Hyun Ju Yoon, Kwang Young Lee, In O Sun
OBJECTIVE: The aim of this study was to investigate the clinical characteristics of sepsis-induced acute kidney injury (AKI) in patients undergoing continuous renal replacement therapy (CRRT). METHODS: From 2011 to 2015, we enrolled 340 patients who were treated with CRRT for sepsis at the Presbyterian Medical Center. In all patients, CRRT was performed using the PRISMA platform. We divided these patients into two groups (survivors and non-survivors) according to the 28-day all-cause mortality...
November 2018: Renal Failure
Shiran Shetty, Shankar Prasad Nagaraju, Srinivas Shenoy, Ravindra Prabhu Attur, Dharshan Rangaswamy, Indu R Rao, Uday Venkat Mateti, Rajeevalochana Parthasarathy
BACKGROUND: Acute kidney injury (AKI) is a common complication of liver cirrhosis and is associated with poor survival. We studied the clinical profile and predictors of in-hospital mortality in patients with cirrhosis of the liver with AKI. METHODS: This retrospective cohort study examined patients at a tertiary care hospital. AKI staging was done based on the new 2015 Ascites Club Criteria. Patients were grouped into three types of AKI: pre-renal azotemia (PRA), hepatorenal syndrome (HRS), and acute tubular necrosis (ATN)...
May 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Agata Bielecka-Dabrowa, Breno Godoy, Joerg C Schefold, Michael Koziolek, Maciej Banach, Stephan von Haehling
PURPOSE OF REVIEW: Acute decompensated heart failure (ADHF) is one of the biggest challenges in the management of chronic heart failure. Despite several advances in medical and device therapy, high readmission and mortality rates continue to be a burden on healthcare systems worldwide. The aim of the current review is to provide an overview on current as well as future approaches in cardiorenal interactions in patients with ADHF. RECENT FINDINGS: One of the strongest predictors of adverse outcomes in ADHF is renal dysfunction, referred to as cardiorenal syndromes (CRS) or cardiorenal interactions...
July 10, 2018: Current Heart Failure Reports
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