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Sajjad ahmad

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https://www.readbyqxmd.com/read/30317274/severe-haemolysis-and-renal-failure-precipitated-by-hepatitis-e-virus-in-g6pd-deficient-patient-a-case-report
#1
Baseer Sultan Ahmad, Adeel Ahmad, Sajjad Jamil, Saiyed Abdullah Abubakar Mohsin Ehsanullah, Abeera Munir
Hepatitis E virus is the etiological agent for Hepatitis E infection, which is congruent to Hepatitis A infection. The clinical spectrum of the disease range from asymptomatic self-limiting disease which requires no treatment to life threatening fulminant liver disease in pregnancy, G6PD deficient and post-liver transplant patients, which necessitate urgent treatment. Similarly we are reporting a case of a 28 year old male with no previous known comorbids, who presented in emergency department with low grade fever, yellow discolouration of eyes and upper abdominal pain for last 5-6 days...
September 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/30306508/antiproliferative-antioxidant-and-binding-mechanism-analysis-of-prodigiosin-from-newly-isolated-radio-resistant-streptomyces-sp-strain-wma-lm31
#2
Wasim Sajjad, Sajjad Ahmad, Iffat Aziz, Syed Sikander Azam, Fariha Hasan, Aamer Ali Shah
Streptomyces genus are filamentous Gram positive bacteria, of great intrest, producing biologically active compounds. Recent market and consumer curiosity in natural products have forced scientist and industry for the development of new products with therapeutic potential. This study focuses on evaluation of antioxidant and anticancerous properties of prodigiosin from radio-resistant Streptomyces sp. strain WMA-LM31. A molecular docking approach was adopted to understand theoretical binding mechanism and affinity for anticancer targets...
October 10, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30280040/biosorption-potential-of-natural-pyrolysed-and-acid-assisted-pyrolysed-sugarcane-bagasse-for-the-removal-of-lead-from-contaminated-water
#3
Ghulam Mustafa Shah, Muhammad Nasir, Muhammad Imran, Hafiz Faiq Bakhat, Faiz Rabbani, Muhammad Sajjad, Abu Bakr Umer Farooq, Sajjad Ahmad, Lifen Song
Lead (Pb) is a ubiquitous pollutant which poses serious threats to plants, animals and humans once entered into the food chain via contaminated industrial effluents on their discharge into the surface of water bodies and/or geological materials. This study aimed to examine and compare the biosorption potential of natural sugarcane bagasse (NB), pyrolysed sugarcane bagasse (PB) and acid assisted pyrolysed sugarcane bagasse (APB) for the removal of Pb from contaminated water. To explore this objective, a series of batch experiments were conducted at various adsorbent mass (0...
2018: PeerJ
https://www.readbyqxmd.com/read/30273644/subtractive-proteomics-and-immunoinformatics-revealed-novel-b-cell-derived-t-cell-epitopes-against-yersinia-enterocolitica-an-etiological-agent-of-yersiniosis
#4
Qurat Ul Ain, Sajjad Ahmad, Syed Sikander Azam
Yersinia enterocolitica is the third most common cause of gastrointestinal manifestations in Europe. Statistically, every year the pathogen accounts for 640 hospitalizations, 117,000 illnesses, and 35 deaths in the United States. The associated mortality rate of the pathogen is 50% and is virtually resistant to penicillin G, ampicillin and cephalotin. The development of new and effective therapeutic procedures is urgently needed to counter the multi-drug-resistant phenotypes imposed by the said pathogen. Based on subtractive reverse vaccinology and immunoinformatics approaches, we have successfully predicted novel antigenic peptide vaccine candidates against Y...
September 28, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/30218800/the-identification-of-factors-that-influence-the-quality-of-bypass-anastomosis-and-an-evaluation-of-the-usefulness-of-an-experimental-practical-scale-in-this-regard
#5
Ahmad Hafez, Justiina Huhtakangas, Muhammad Sajjad, Michael T Lawton, Rokuya Tanikawa, Mika Niemelä
BACKGROUND: Several factors associated with interrupted and continuous suturing techniques affect the quality of bypass anastomosis. It is difficult to determine the impact of these during surgery. Thus, the primary study objective was to evaluate factors with the potential to influence the quality of bypass anastomosis using either interrupted or continuous suturing. A secondary objective was to evaluate the usefulness of a practical scale when comparing interrupted and continuous suturing techniques, in order to improve bypass anastomosis...
September 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30140674/corrigendum-ursolic-acid-hydrazide-based-organometallic-complexes-synthesis-characterization-antibacterial-antioxidant-and-docking-studies
#6
Muafia Jabeen, Sajjad Ahmad, Khadija Shahid, Abdul Sadiq, Umer Rashid
[This corrects the article DOI: 10.3389/fchem.2018.00055.].
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/30133634/dengue-seroprevalence-and-its-socioeconomic-determinants-in-faisalabad-pakistan-a-cross-sectional-study
#7
Faiz Ahmed Raza, Sajjad Ashraf, Shahida Hasnain, Jameel Ahmad, Mazhar Iqbal
INTRODUCTION: Socioeconomic disparities in the community make some groups more vulnerable to dengue infection. METHODS: Fourteen dengue cases (IgM positive) served as index cases for the positive geographic cluster investigations. RESULTS: Of 292 individuals, the overall dengue seroprevalence was 22.9% (IgM positive 4.8%; IgG positive 18.1%). The highest (45%) seroprevalence was reported in the most socioeconomically vulnerable lower class, followed by the middle class (39%)...
July 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/30123847/twenty-years-of-limbal-epithelial-therapy-an-update-on-managing-limbal-stem-cell-deficiency
#8
REVIEW
Roberto Fernandez-Buenaga, Francesco Aiello, Sarah S Zaher, Andre Grixti, Sajjad Ahmad
Limbal stem cell damage after chemical injury, autoimmune disorders or iatrogenic trauma leads to corneal conjunctivalisation with new vessel formation, epithelium instability and visual loss. Limbal stem cell transplantation includes reconstructive surgical procedures to restore a corneal epithelium. The recognised options are: conjunctival limbal autograft, in which stem cells are taken from the patient's healthy eye; conjunctival limbal allograft, in which stem cells are taken from a living, related or dead donor and the keratolimbal allograft...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/30120293/improving-precision-for-detecting-change-in-the-shape-of-the-cornea-in-patients-with-keratoconus
#9
Matthias Brunner, Gabriela Czanner, Riccardo Vinciguerra, Vito Romano, Sajjad Ahmad, Mark Batterbury, Claire Britten, Colin E Willoughby, Stephen B Kaye
To investigate a method for precision analysis to discriminate true corneal change from measurement imprecision in keratoconus (KC). Thirty patients with KC and 30 healthy controls were included. Coefficients of repeatability and limits of agreement (LOA) were compared using multiple measurements for inter-observer and inter-device agreement with the Pentacam HR, Orbscan IIz, and Tomey Casia SS-1000. Correlation of repeated measurements was evaluated using a linear mixed effect model (also called random effect model)...
August 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30100987/transcriptome-profiling-of-anti-m%C3%A3-llerian-hormone-treated-preantral-small-antral-mouse-ovary-follicles
#10
Zia Ur Rehman, Faheem Ahmad Khan, Farmanullah, Hira Sajjad Talpur, Qing Liu, Shenhe Liu, Liguo Yang
The predisposition for the initiation of folliculogenesis in mammals including humans is programmed to start at fetal life and continues until reproductive capacity. The follicles grow from a pool of primordial follicles which retain the major functions in the entire reproductive life of a female. Anti-müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta family, has an inhibitory effect on ovarian follicle development. The key regulatory target genes in primordial follicle development are of paramount importance in reproductive biology of female...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30078661/proteome-wide-identification-of-epitope-based-vaccine-candidates-against-multi-drug-resistant-proteus-mirabilis
#11
Nosheen Ehsan, Sajjad Ahmad, Syed Sikander Azam, Thanyada Rungrotmongkol, Reaz Uddin
Proteus mirabilis is one of the important pathogens of urinary tract and exhibits resistance to multiple drugs. Development of vaccine tends to be the most promising and cost-effective remedy against the said pathogen. Herein, we implement a combinatorial approach for screening proteins harboring potential broad-spectrum antigenic epitopes in the proteome of P. mirabilis. The targets are host non-homologous, essential and virulent, and have localization in the extracellular and outer membrane. Immuno-informatics revealed antigenic, surface exposed and broad-spectrum B-cell derived T-cell epitopes for three membrane usher family candidates: AtfC, PMI2533 and PMI1466, which could evoke a substantial immune response...
September 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/30043709/moleculer-dynamics-simulaiton-revealed-reciever-domain-of-acinetobacter-baumannii-bfmr-enzyme-as-the-hot-spot-for-future-antibiotics-designing
#12
Sajjad Ahmad, Bilal Shaker, Faisal Ahmad, Saad Raza, Syed Sikander Azam
Acinetobacter baumannii is an alarming nosocomial pathogen that is resistant to multiple drugs. The pathogen is forefront of scientific attention because of high mortality and morbidity found for its complications in the past decade. As a consequence, identification of novel drug candidates and subsequent designing of novel chemical scaffolds is an imperative need of time. In the present study, we used a recently reported structure of BfmR enzyme and performed structure based virtual screening, MD simulation and binding free energies calculations...
July 25, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/30018995/situational-analysis-of-cutaneous-leishmaniasis-in-an-endemic-focus-of-the-disease-southeastern-iran
#13
Sajjad Fekri, Ahmad Ali Hanafi-Bojd, Yousef Salari, Parivash Davoodian, Reza Safari, Habib Dadvand, Mohsen Mohebbi, Hossein Issazadeh, Zahra Kamali
Background: Leishmaniasis is one of the most important vector-borne diseases in Iran, existing in a variety of forms ranging from cutaneous to visceral forms. Jask County has been recognized as an endemic focus of the disease in the southeastern region of Iran. This study analyzed the situation of cutaneous leishmaniasis (CL) during 2006-2014. Methods: This cross-sectional analytical study was conducted on CL data got from health sector. ArcGIS 10.3 was exploited for the spatial analysis of CL...
March 2018: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/30011792/role-of-damage-associated-molecular-pattern-molecules-damps-in-aneurysmal-subarachnoid-hemorrhage-asah
#14
REVIEW
Shafqat Rasul Chaudhry, Ahmad Hafez, Behnam Rezai Jahromi, Thomas Mehari Kinfe, Alf Lamprecht, Mika Niemelä, Sajjad Muhammad
Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes, but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical clipping and endovascular coiling can successfully obliterate the bleeding aneurysms, but ensuing complications such as cerebral vasospasm, acute and chronic hydrocephalus, seizures, cortical spreading depression, delayed ischemic neurological deficits, and delayed cerebral ischemia lead to poor clinical outcomes. The mechanisms leading to these complications are complex and poorly understood...
July 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29983283/corrigendum-to-synthesis-structure-activity-relationship-and-molecular-docking-studies-of-3-o-flavonol-glycosides-as-cholinesterase-inhibitors-bioorg-med-chem-26-12-2018-3696-3706
#15
Ehsan Ullah Mughal, Asif Javid, Amina Sadiq, Shahzad Murtaza, Muhammad Naveed Zafar, Bilal Ahmad Khan, Sajjad Hussain Sumrra, Muhammad Nawaz Tahir, Kanwal, Khalid Mohammed Khan
No abstract text is available yet for this article.
July 30, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29950997/chemical-characterization-analgesic-antioxidant-and-anticholinesterase-potentials-of-essential-oils-from-isodon-rugosus-wall-ex-benth
#16
Abdul Sadiq, Anwar Zeb, Farhat Ullah, Sajjad Ahmad, Muhammad Ayaz, Umer Rashid, Noor Muhammad
Isodon rugosus Wall. ex. Benth is an important species and is used in folk medicine for different types of pains such as abdominal pain, earache, toothache, gastric, and generalized body pain. Recently, we also have reported the antinociceptive potential of chloroform fraction of I. rugosus . In this research, we have investigated the antinociceptive, antioxidant and anti-cholinesterase potentials of essential oils from I. rugosus (Ir.EO), and have determined a possible mechanism of anti-nociception. The Ir...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29886083/synthesis-structure-activity-relationship-and-molecular-docking-studies-of-3-o-flavonol-glycosides-as-cholinesterase-inhibitors
#17
Ehsan Ullah Mughal, Asif Javid, Amina Sadiq, Shahzad Murtaza, Muhammad Naveed Zafar, Bilal Ahmad Khan, Sajjad Hussain Sumrra, Muhammad Nawaz Tahir, Kanwal, Khalid Mohammed Khan
The prime objective of this research work is to prepare readily soluble synthetic analogues of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various substituents on biological properties of synthetic compounds. In this context, a series of varyingly substituted 3-O-flavonol glycosides have been designed, synthesized and characterized efficiently. The structures of synthetic molecules were unambiguously corroborated by IR, 1 H, 13 C NMR and ESI-MS spectroscopic techniques...
July 23, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29862252/comparative-analysis-of-v-akt-murine-thymoma-viral-oncogene-homolog-3-akt3-gene-between-cow-and-buffalo-reveals-substantial-differences-for-mastitis
#18
Farman Ullah, Dinesh Bhattarai, Zhangrui Cheng, Xianwei Liang, Tingxian Deng, Zia Ur Rehman, Hira Sajjad Talpur, Tesfaye Worku, Rahim Dad Brohi, Muhammad Safdar, Muhammad Jamil Ahmad, Mohammad Salim, Momen Khan, Hafiz Ishfaq Ahmad, Shujun Zhang
AKT3 gene is a constituent of the serine/threonine protein kinase family and plays a crucial role in synthesis of milk fats and cholesterol by regulating activity of the sterol regulatory element binding protein (SREBP). AKT3 is highly conserved in mammals and its expression levels during the lactation periods of cattle are markedly increased. AKT3 is highly expressed in the intestine followed by mammary gland and it is also expressed in immune cells. It is involved in the TLR pathways as effectively as proinflammatory cytokines...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29800578/simple-limbal-epithelial-transplantation-a-review-on-current-approach-and-future-directions
#19
Davide Borroni, Bogumil Wowra, Vito Romano, Maria Boyadzhieva, Diego Ponzin, Stefano Ferrari, Sajjad Ahmad, Mohit Parekh
Simple limbal epithelial transplantation is a recently developed technique for treating limbal stem cell deficiency caused by ocular burns. A small limbal biopsy from the donor eye, usually from the patient's healthy eye, is excised and dissected into multiple pieces. An amniotic membrane is atttached using fibrin glue on the diseased eye after removing the conjunctivalized pannus from the corneal surface. The limbal biopsy pieces are placed onto the amniotic membrane, fixed with fibrin glue, followed by bandaging of the ocular surface with a contact lens...
November 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29753164/a-novel-approach-of-virulome-based-reverse-vaccinology-for-exploring-and-validating-peptide-based-vaccine-candidates-against-the-most-troublesome-nosocomial-pathogen-acinetobacter-baumannii
#20
Sajjad Ahmad, Syed Sikander Azam
Acinetobacter baumannii is one of the major cause of nosocomial infections around the globe. The emergence of hyper-virulent strains of the pathogen greatly narrows down therapeutic options for patients infected with this red alert superbug. Development of a peptide-based vaccine can offers an alternative, attractive, and cost-effective remedy for multidrug-resistant A. baumannii associated complications. Herein, we introduced a novel virulome based Reverse Vaccinology for screening peptide based vaccine candidates against A...
August 2018: Journal of Molecular Graphics & Modelling
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