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Sajjad ahmad

Khizar Hayat, Muhammad Afzal, Muhammad Anjum Aqueel, Sajjad Ali, Muhammad Farhan Saeed, Ahmad Kaleem Qureshi, Muhammad Irfan Ullah, Qaiser M Khan, Muhammad Tayyib Naseem, Umair Ashfaq, Christos A Damalas
Biomonitoring of people exposed to hazardous materials provides opportunities for early identification of several diseases, particularly in those individuals who are constantly exposed to pesticides, such as pesticide operators and workers in pesticide manufacturing industry. However, data on this hot topic are limited in Pakistan. In this study, insecticide toxic effects and biochemical alterations (i.e., damage in DNA and enzyme activity) were studied in blood samples of occupationally exposed individuals from Punjab, Pakistan...
November 13, 2018: Science of the Total Environment
Asad Ullah Jan, Sajjad Ahmad, Tehseen Ahmad Cheema, Farman Ullah, Muhammad Waqar, Baqir Hussain
Chondroectodermal syndrome or Ellis Van Creveld (EVC) is a rare autosomal recessive congenital disorder. It was first described by Richard W.B.Ellis and Simon Van Creveld in 1940. Parental consanguinity is present in about 30% of the cases. A large number of cases were reported in Amish population of Lancaster County, Pennsylvania USA and also in Aboriginal community of Australia in 1964. The incidence in Amish population is 1/5000 live births and in general population 7/1,000,000. There are only 150 cases reported worldwide...
July 2018: Journal of Ayub Medical College, Abbottabad: JAMC
Fawad Ahmad Randhawa, Nasir Farooq Butt, Syed Osama Talat, Sajjad Hussain Sabir, Muhammad Adeel Qamar
OBJECTIVE: To compare the improvement of dilatation among patients receiving intralesional steroid injection with dilatation versus dilatation alone for the management of corrosive ooesophageal strictures. METHODS: The randomized controlled trial was conducted at Mayo Hospital, Lahore, Pakistan, from November 10, 2014, to November 10, 2015, and comprised patients of either gender aged 15-50years who had corrosive ooesophageal stricture. They were randomised into 2 groups by using the lottery method...
November 2018: JPMA. the Journal of the Pakistan Medical Association
Ateeq-Ur-Rauf, Abdul Razzaq Ghumman, Sajjad Ahmad, Hashim Nisar Hashmi
Water resources planning, development, and management need reliable forecasts of river flows. In past few decades, an important dimension has been introduced in the prediction of the hydrologic phenomenon through artificial intelligence-based modeling. In this paper, the performance of three artificial neural network (ANN) and four support vector regression (SVR) models was investigated to predict streamflows in the Upper Indus River. Results from ANN models using three different optimization techniques, namely Broyden-Fletcher-Goldfarb-Shannon, Conjugate Gradient, and Back Propagation algorithms, were compared with one another...
November 8, 2018: Environmental Monitoring and Assessment
Hassan Tahir, Sajjad Ahmad, Muhammad U Awan, Bassam Omar, Joey Glass, Jason Cole
Congenital coronary anomalies are uncommon and are mostly asymptomatic; however, patients may have symptoms depending on the origin and course of anomalous artery. Very rarely, coronary anomalies can also lead to life-threatening complications especially in young athletes. A malignant course of the left main (LM) or left anterior descending (LAD) artery between aorta and pulmonary artery is considered the most significant risk factor for such complications. Various noninvasive tests are available to evaluate myocardial ischemia due to anomalous coronary artery...
August 28, 2018: Curēus
Shafi Balal, Arit Udoh, Yannis Pappas, Erica Cook, Garry Barton, Ali Hassan, Karen Hayden, Rupert Richard Alexander Bourne, Sajjad Ahmad, Shahina Pardhan, Michael Harrison, Benjamin Sharma, Mohammad Wasil, Anant Sharma
INTRODUCTION: Patients with severe dry eye disease (DED) often have limited treatment options with standard non-surgical management focused on the use of artificial tears for lubrication and anti-inflammatory drugs. However, artificial tears do not address the extraordinary complexity of human tears. Crudely, human tears with its vast constituents is essentially filtered blood. Blood and several blood-derived products including autologous serum, have been studied as tear substitutes. This study proposes to test the use of whole, fresh, autologous blood obtained from a finger prick for treatment of severe DED...
October 31, 2018: BMJ Open
Baseer Sultan Ahmad, Adeel Ahmad, Sajjad Jamil, Saiyed Abdullah Abubakar Mohsin Ehsanullah, Abeera Munir
Hepatitis E virus is the etiological agent for Hepatitis E infection, which is congruent to Hepatitis A infection. The clinical spectrum of the disease range from asymptomatic self-limiting disease which requires no treatment to life threatening fulminant liver disease in pregnancy, G6PD deficient and post-liver transplant patients, which necessitate urgent treatment. Similarly we are reporting a case of a 28 year old male with no previous known comorbids, who presented in emergency department with low grade fever, yellow discolouration of eyes and upper abdominal pain for last 5-6 days...
September 2018: JPMA. the Journal of the Pakistan Medical Association
Wasim Sajjad, Sajjad Ahmad, Iffat Aziz, Syed Sikander Azam, Fariha Hasan, Aamer Ali Shah
Streptomyces genus are filamentous Gram positive bacteria, of great intrest, producing biologically active compounds. Recent market and consumer curiosity in natural products have forced scientist and industry for the development of new products with therapeutic potential. This study focuses on evaluation of antioxidant and anticancerous properties of prodigiosin from radio-resistant Streptomyces sp. strain WMA-LM31. A molecular docking approach was adopted to understand theoretical binding mechanism and affinity for anticancer targets...
October 10, 2018: Molecular Biology Reports
Ghulam Mustafa Shah, Muhammad Nasir, Muhammad Imran, Hafiz Faiq Bakhat, Faiz Rabbani, Muhammad Sajjad, Abu Bakr Umer Farooq, Sajjad Ahmad, Lifen Song
Lead (Pb) is a ubiquitous pollutant which poses serious threats to plants, animals and humans once entered into the food chain via contaminated industrial effluents on their discharge into the surface of water bodies and/or geological materials. This study aimed to examine and compare the biosorption potential of natural sugarcane bagasse (NB), pyrolysed sugarcane bagasse (PB) and acid assisted pyrolysed sugarcane bagasse (APB) for the removal of Pb from contaminated water. To explore this objective, a series of batch experiments were conducted at various adsorbent mass (0...
2018: PeerJ
Qurat Ul Ain, Sajjad Ahmad, Syed Sikander Azam
Yersinia enterocolitica is the third most common cause of gastrointestinal manifestations in Europe. Statistically, every year the pathogen accounts for 640 hospitalizations, 117,000 illnesses, and 35 deaths in the United States. The associated mortality rate of the pathogen is 50% and is virtually resistant to penicillin G, ampicillin and cephalotin. The development of new and effective therapeutic procedures is urgently needed to counter the multi-drug-resistant phenotypes imposed by the said pathogen. Based on subtractive reverse vaccinology and immunoinformatics approaches, we have successfully predicted novel antigenic peptide vaccine candidates against Y...
September 28, 2018: Microbial Pathogenesis
Ahmad Hafez, Justiina Huhtakangas, Sajjad Muhammad, Michael T Lawton, Rokuya Tanikawa, Mika Niemelä
BACKGROUND: Several factors associated with interrupted and continuous suturing techniques affect the quality of bypass anastomosis. It is difficult to determine the impact of these factors during surgery. The primary objective of this study was to evaluate factors with the potential to influence the quality of bypass anastomosis using either interrupted or continuous suturing. A secondary objective was to evaluate the usefulness of a practical scale when comparing interrupted and continuous suturing techniques to improve bypass anastomosis...
September 12, 2018: World Neurosurgery
Muafia Jabeen, Sajjad Ahmad, Khadija Shahid, Abdul Sadiq, Umer Rashid
[This corrects the article DOI: 10.3389/fchem.2018.00055.].
2018: Frontiers in Chemistry
Faiz Ahmed Raza, Sajjad Ashraf, Shahida Hasnain, Jameel Ahmad, Mazhar Iqbal
INTRODUCTION: Socioeconomic disparities in the community make some groups more vulnerable to dengue infection. METHODS: Fourteen dengue cases (IgM positive) served as index cases for the positive geographic cluster investigations. RESULTS: Of 292 individuals, the overall dengue seroprevalence was 22.9% (IgM positive 4.8%; IgG positive 18.1%). The highest (45%) seroprevalence was reported in the most socioeconomically vulnerable lower class, followed by the middle class (39%)...
July 2018: Revista da Sociedade Brasileira de Medicina Tropical
Roberto Fernandez-Buenaga, Francesco Aiello, Sarah S Zaher, Andre Grixti, Sajjad Ahmad
Limbal stem cell damage after chemical injury, autoimmune disorders or iatrogenic trauma leads to corneal conjunctivalisation with new vessel formation, epithelium instability and visual loss. Limbal stem cell transplantation includes reconstructive surgical procedures to restore a corneal epithelium. The recognised options are: conjunctival limbal autograft, in which stem cells are taken from the patient's healthy eye; conjunctival limbal allograft, in which stem cells are taken from a living, related or dead donor and the keratolimbal allograft...
2018: BMJ Open Ophthalmology
Matthias Brunner, Gabriela Czanner, Riccardo Vinciguerra, Vito Romano, Sajjad Ahmad, Mark Batterbury, Claire Britten, Colin E Willoughby, Stephen B Kaye
To investigate a method for precision analysis to discriminate true corneal change from measurement imprecision in keratoconus (KC). Thirty patients with KC and 30 healthy controls were included. Coefficients of repeatability and limits of agreement (LOA) were compared using multiple measurements for inter-observer and inter-device agreement with the Pentacam HR, Orbscan IIz, and Tomey Casia SS-1000. Correlation of repeated measurements was evaluated using a linear mixed effect model (also called random effect model)...
August 17, 2018: Scientific Reports
Zia Ur Rehman, Faheem Ahmad Khan, Farmanullah, Hira Sajjad Talpur, Qing Liu, Shenhe Liu, Liguo Yang
The predisposition for the initiation of folliculogenesis in mammals including humans is programmed to start at fetal life and continues until reproductive capacity. The follicles grow from a pool of primordial follicles which retain the major functions in the entire reproductive life of a female. Anti-müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta family, has an inhibitory effect on ovarian follicle development. The key regulatory target genes in primordial follicle development are of paramount importance in reproductive biology of female...
July 13, 2018: Oncotarget
Nosheen Ehsan, Sajjad Ahmad, Syed Sikander Azam, Thanyada Rungrotmongkol, Reaz Uddin
Proteus mirabilis is one of the important pathogens of urinary tract and exhibits resistance to multiple drugs. Development of vaccine tends to be the most promising and cost-effective remedy against the said pathogen. Herein, we implement a combinatorial approach for screening proteins harboring potential broad-spectrum antigenic epitopes in the proteome of P. mirabilis. The targets are host non-homologous, essential and virulent, and have localization in the extracellular and outer membrane. Immuno-informatics revealed antigenic, surface exposed and broad-spectrum B-cell derived T-cell epitopes for three membrane usher family candidates: AtfC, PMI2533 and PMI1466, which could evoke a substantial immune response...
September 2018: Biologicals: Journal of the International Association of Biological Standardization
Sajjad Ahmad, Bilal Shaker, Faisal Ahmad, Saad Raza, Syed Sikander Azam
Acinetobacter baumannii is an alarming nosocomial pathogen that is resistant to multiple drugs. The pathogen is forefront of scientific attention because of high mortality and morbidity found for its complications in the past decade. As a consequence, identification of novel drug candidates and subsequent designing of novel chemical scaffolds is an imperative need of time. In the present study, we used a recently reported structure of BfmR enzyme and performed structure based virtual screening, MD simulation and binding free energies calculations...
July 25, 2018: Journal of Biomolecular Structure & Dynamics
Sajjad Fekri, Ahmad Ali Hanafi-Bojd, Yousef Salari, Parivash Davoodian, Reza Safari, Habib Dadvand, Mohsen Mohebbi, Hossein Issazadeh, Zahra Kamali
Background: Leishmaniasis is one of the most important vector-borne diseases in Iran, existing in a variety of forms ranging from cutaneous to visceral forms. Jask County has been recognized as an endemic focus of the disease in the southeastern region of Iran. This study analyzed the situation of cutaneous leishmaniasis (CL) during 2006-2014. Methods: This cross-sectional analytical study was conducted on CL data got from health sector. ArcGIS 10.3 was exploited for the spatial analysis of CL...
March 2018: Journal of Arthropod-borne Diseases
Shafqat Rasul Chaudhry, Ahmad Hafez, Behnam Rezai Jahromi, Thomas Mehari Kinfe, Alf Lamprecht, Mika Niemelä, Sajjad Muhammad
Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes, but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical clipping and endovascular coiling can successfully obliterate the bleeding aneurysms, but ensuing complications such as cerebral vasospasm, acute and chronic hydrocephalus, seizures, cortical spreading depression, delayed ischemic neurological deficits, and delayed cerebral ischemia lead to poor clinical outcomes. The mechanisms leading to these complications are complex and poorly understood...
July 13, 2018: International Journal of Molecular Sciences
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