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Sajjad ahmad

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https://www.readbyqxmd.com/read/30100987/transcriptome-profiling-of-anti-m%C3%A3-llerian-hormone-treated-preantral-small-antral-mouse-ovary-follicles
#1
Zia Ur Rehman, Faheem Ahmad Khan, Farmanullah, Hira Sajjad Talpur, Qing Liu, Shenhe Liu, Liguo Yang
The predisposition for the initiation of folliculogenesis in mammals including humans is programmed to start at fetal life and continues until reproductive capacity. The follicles grow from a pool of primordial follicles which retain the major functions in the entire reproductive life of a female. Anti-müllerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta family, has an inhibitory effect on ovarian follicle development. The key regulatory target genes in primordial follicle development are of paramount importance in reproductive biology of female...
July 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/30078661/proteome-wide-identification-of-epitope-based-vaccine-candidates-against-multi-drug-resistant-proteus-mirabilis
#2
Nosheen Ehsan, Sajjad Ahmad, Syed Sikander Azam, Thanyada Rungrotmongkol, Reaz Uddin
Proteus mirabilis is one of the important pathogens of urinary tract and exhibits resistance to multiple drugs. Development of vaccine tends to be the most promising and cost-effective remedy against the said pathogen. Herein, we implement a combinatorial approach for screening proteins harboring potential broad-spectrum antigenic epitopes in the proteome of P. mirabilis. The targets are host non-homologous, essential and virulent, and have localization in the extracellular and outer membrane. Immuno-informatics revealed antigenic, surface exposed and broad-spectrum B-cell derived T-cell epitopes for three membrane usher family candidates: AtfC, PMI2533 and PMI1466, which could evoke a substantial immune response...
August 2, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/30043709/moleculer-dynamics-simulaiton-revealed-reciever-domain-of-acinetobacter-baumannii-bfmr-enzyme-as-the-hot-spot-for-future-antibiotics-designing
#3
Sajjad Ahmad, Bilal Shaker, Faisal Ahmad, Saad Raza, Syed Sikander Azam
Acinetobacter baumannii is an alarming nosocomial pathogen that is resistant to multiple drugs. The pathogen is forefront of scientific attention because of high mortality and morbidity found for its complications in the past decade. As a consequence, identification of novel drug candidates and subsequent designing of novel chemical scaffolds is an imperative need of time. In the present study, we used a recently reported structure of BfmR enzyme and performed structure based virtual screening, MD simulation and binding free energies calculations...
July 25, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/30018995/situational-analysis-of-cutaneous-leishmaniasis-in-an-endemic-focus-of-the-disease-southeastern-iran
#4
Sajjad Fekri, Ahmad Ali Hanafi-Bojd, Yousef Salari, Parivash Davoodian, Reza Safari, Habib Dadvand, Mohsen Mohebbi, Hossein Issazadeh, Zahra Kamali
Background: Leishmaniasis is one of the most important vector-borne diseases in Iran, existing in a variety of forms ranging from cutaneous to visceral forms. Jask County has been recognized as an endemic focus of the disease in the southeastern region of Iran. This study analyzed the situation of cutaneous leishmaniasis (CL) during 2006-2014. Methods: This cross-sectional analytical study was conducted on CL data got from health sector. ArcGIS 10.3 was exploited for the spatial analysis of CL...
March 2018: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/30011792/role-of-damage-associated-molecular-pattern-molecules-damps-in-aneurysmal-subarachnoid-hemorrhage-asah
#5
REVIEW
Shafqat Rasul Chaudhry, Ahmad Hafez, Behnam Rezai Jahromi, Thomas Mehari Kinfe, Alf Lamprecht, Mika Niemelä, Sajjad Muhammad
Aneurysmal subarachnoid hemorrhage (aSAH) represents only a small portion of all strokes, but accounts for almost half of the deaths caused by stroke worldwide. Neurosurgical clipping and endovascular coiling can successfully obliterate the bleeding aneurysms, but ensuing complications such as cerebral vasospasm, acute and chronic hydrocephalus, seizures, cortical spreading depression, delayed ischemic neurological deficits, and delayed cerebral ischemia lead to poor clinical outcomes. The mechanisms leading to these complications are complex and poorly understood...
July 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29983283/corrigendum-to-synthesis-structure-activity-relationship-and-molecular-docking-studies-of-3-o-flavonol-glycosides-as-cholinesterase-inhibitors-bioorg-med-chem-26-12-2018-3696-3706
#6
Ehsan Ullah Mughal, Asif Javid, Amina Sadiq, Shahzad Murtaza, Muhammad Naveed Zafar, Bilal Ahmad Khan, Sajjad Hussain Sumrra, Muhammad Nawaz Tahir, Kanwal, Khalid Mohammed Khan
No abstract text is available yet for this article.
July 30, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29950997/chemical-characterization-analgesic-antioxidant-and-anticholinesterase-potentials-of-essential-oils-from-isodon-rugosus-wall-ex-benth
#7
Abdul Sadiq, Anwar Zeb, Farhat Ullah, Sajjad Ahmad, Muhammad Ayaz, Umer Rashid, Noor Muhammad
Isodon rugosus Wall. ex. Benth is an important species and is used in folk medicine for different types of pains such as abdominal pain, earache, toothache, gastric, and generalized body pain. Recently, we also have reported the antinociceptive potential of chloroform fraction of I. rugosus . In this research, we have investigated the antinociceptive, antioxidant and anti-cholinesterase potentials of essential oils from I. rugosus (Ir.EO), and have determined a possible mechanism of anti-nociception. The Ir...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29886083/synthesis-structure-activity-relationship-and-molecular-docking-studies-of-3-o-flavonol-glycosides-as-cholinesterase-inhibitors
#8
Ehsan Ullah Mughal, Asif Javid, Amina Sadiq, Shahzad Murtaza, Muhammad Naveed Zafar, Bilal Ahmad Khan, Sajjad Hussain Sumrra, Muhammad Nawaz Tahir, Kanwal, Khalid Mohammed Khan
The prime objective of this research work is to prepare readily soluble synthetic analogues of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various substituents on biological properties of synthetic compounds. In this context, a series of varyingly substituted 3-O-flavonol glycosides have been designed, synthesized and characterized efficiently. The structures of synthetic molecules were unambiguously corroborated by IR, 1 H, 13 C NMR and ESI-MS spectroscopic techniques...
July 23, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29862252/comparative-analysis-of-v-akt-murine-thymoma-viral-oncogene-homolog-3-akt3-gene-between-cow-and-buffalo-reveals-substantial-differences-for-mastitis
#9
Farman Ullah, Dinesh Bhattarai, Zhangrui Cheng, Xianwei Liang, Tingxian Deng, Zia Ur Rehman, Hira Sajjad Talpur, Tesfaye Worku, Rahim Dad Brohi, Muhammad Safdar, Muhammad Jamil Ahmad, Mohammad Salim, Momen Khan, Hafiz Ishfaq Ahmad, Shujun Zhang
AKT3 gene is a constituent of the serine/threonine protein kinase family and plays a crucial role in synthesis of milk fats and cholesterol by regulating activity of the sterol regulatory element binding protein (SREBP). AKT3 is highly conserved in mammals and its expression levels during the lactation periods of cattle are markedly increased. AKT3 is highly expressed in the intestine followed by mammary gland and it is also expressed in immune cells. It is involved in the TLR pathways as effectively as proinflammatory cytokines...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29800578/simple-limbal-epithelial-transplantation-a-review-on-current-approach-and-future-directions
#10
Davide Borroni, Bogumil Wowra, Vito Romano, Maria Boyadzhieva, Diego Ponzin, Stefano Ferrari, Sajjad Ahmad, Mohit Parekh
Simple limbal epithelial transplantation is a recently developed technique for treating limbal stem cell deficiency caused by ocular burns. A small limbal biopsy from the donor eye, usually from the patient's healthy eye, is excised and dissected into multiple pieces. An amniotic membrane is atttached using fibrin glue on the diseased eye after removing the conjunctivalized pannus from the corneal surface. The limbal biopsy pieces are placed onto the amniotic membrane, fixed with fibrin glue, followed by bandaging of the ocular surface with a contact lens...
May 22, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29753164/a-novel-approach-of-virulome-based-reverse-vaccinology-for-exploring-and-validating-peptide-based-vaccine-candidates-against-the-most-troublesome-nosocomial-pathogen-acinetobacter-baumannii
#11
Sajjad Ahmad, Syed Sikander Azam
Acinetobacter baumannii is one of the major cause of nosocomial infections around the globe. The emergence of hyper-virulent strains of the pathogen greatly narrows down therapeutic options for patients infected with this red alert superbug. Development of a peptide-based vaccine can offers an alternative, attractive, and cost-effective remedy for multidrug-resistant A. baumannii associated complications. Herein, we introduced a novel virulome based Reverse Vaccinology for screening peptide based vaccine candidates against A...
August 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29729069/ectoine-a-compatible-solute-in-radio-halophilic-stenotrophomonas-sp-wma-lm19-strain-to-prevent-ultraviolet-induced-protein-damage
#12
W Sajjad, S Qadir, M Ahmad, M Rafiq, F Hasan, R Tehan, K L McPhail, A A Shah
AIM: Thiss study was conducted to investigate the possible role of a compatible solute from radio-halophilic bacterium against desiccation and ultra-violet radiation-induced oxidative stress. METHODS AND RESULTS: Nine different radio-resistant bacteria were isolated from desert soil, where strain WMA-LM19 was chosen for detailed studies on the basis of its high tolerance to ultraviolet radiation among all these isolates. Here, 16S rRNA gene sequencing indicated the bacterium was closely related to Stenotrophomonas sp...
August 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29725563/clinicoradiological-correlation-of-infarct-patterns-on-diffusion-weighted-magnetic-resonance-imaging-in-stroke
#13
Zainab Hussain, Kiran Hilal, Muhammad Ahmad, Zafar Sajjad, Raza Sayani
Diffusion-weighted magnetic resonance imaging (DW-MRI) represents a major advance in the early diagnosis of acute ischemic stroke. It can detect edema due to ischemia in the brain tissue. It not only establishes the presence and location of ischemic brain injury but also a relatively new concept is the determination of infarct patterns seen on diffusion imaging and its clinical correlation. Objective To determine the frequency of various infarct patterns and their relationship with functional outcome of the patient...
March 2, 2018: Curēus
https://www.readbyqxmd.com/read/29721784/subtractive-genomics-molecular-docking-and-molecular-dynamics-simulation-revealed-lpxc-as-a-potential-drug-target-against-multi-drug-resistant-klebsiella-pneumoniae
#14
Sajjad Ahmad, Afifa Navid, Amina Saleem Akhtar, Syed Sikander Azam, Abdul Wadood, Horacio Pérez-Sánchez
The emergence and dissemination of pan drug resistant clones of Klebsiella pneumoniae are great threat to public health. In this regard new therapeutic targets must be highlighted to pave the path for novel drug discovery and development. Subtractive proteomic pipeline brought forth UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC), a Zn+2 dependent cytoplasmic metalloprotein and catalyze the rate limiting deacetylation step of lipid A biosynthesis pathway. Primary sequence analysis followed by 3-dimensional (3-D) structure elucidation of the protein led to the detection of K...
May 2, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29715280/efficient-estimation-of-pareto-model-some-modified-percentile-estimators
#15
Sajjad Haider Bhatti, Shahzad Hussain, Tanvir Ahmad, Muhammad Aslam, Muhammad Aftab, Muhammad Ali Raza
The article proposes three modified percentile estimators for parameter estimation of the Pareto distribution. These modifications are based on median, geometric mean and expectation of empirical cumulative distribution function of first-order statistic. The proposed modified estimators are compared with traditional percentile estimators through a Monte Carlo simulation for different parameter combinations with varying sample sizes. Performance of different estimators is assessed in terms of total mean square error and total relative deviation...
2018: PloS One
https://www.readbyqxmd.com/read/29705560/comparative-subtractive-proteomics-based-ranking-for-antibiotic-targets-against-the-dirtiest-superbug-acinetobacter-baumannii
#16
Sajjad Ahmad, Saad Raza, Reaz Uddin, Syed Sikander Azam
Multidrug-resistant Acinetobacter baumannii is indeed to be the most successful nosocomial pathogen responsible for myriad infections in modern health care system. Computational methodologies based on genomics and proteomics proved to be powerful tools for providing substantial information about different aspects of A. baumannii biology that made it possible to design new approaches for treating multi, extensive and total drug resistant isolates of A. baumannii. In this current approach, 35 completely annotated proteomes of A...
June 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29700704/synthesis-of-antibacterial-poly-o-chloroaniline-chromium-hybrid-composites-with-enhanced-electrical-conductivity
#17
Mirza Nadeem Ahmad, Fakher Rafique, Faisal Nawaz, Tahir Farooq, Muhammad Naveed Anjum, Tajamal Hussain, Sajjad Hassan, Madeeha Batool, Hamad Khalid, Khurram Shehzad
Electrically conductive polyorthochloroaniline/chromium nanocomposites (POC/Cr NCs) were prepared by in situ chemical oxidative polymerization of orthochloroaniline in the presence of Cr nanoparticles (Cr NPs). The load percentage of Cr nanofiller was varied in POC matrix to investigate the effect of Cr nanoparticles on the properties of the nanocomposites. The composition, structure, and morphology of POC and its composites were examined by Scanning electron microscopy, Fourier transform infrared spectroscopy, and UV-visible spectroscopic analysis...
April 26, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29666090/rare-case-of-chorea-hyperglycaemia-basal-ganglia-c-h-bg-syndrome
#18
Sajjad Ahmad, Priya Mohan Babu, Lavanya Shenbagaraj, Lindsay George
An 83-year-old woman presented with acute-onset haemichorea and haemiballism particularly affecting the left side of the body. She was known to have type 2 diabetes, which was poorly controlled with sitagliptin. She was hyperglycaemic but not ketotic or acidotic. After she was started on insulin and good glycaemic control was achieved, her abnormal movements dramatically improved. MRI of the brain showed a T1-weighted hyperintense lesion on the right basal ganglia, which is typical of chorea-hyperglycaemia-basal ganglia syndrome...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29615318/effect-of-vitamin-d-supplementation-on-anthropometric-indices-among-overweight-and-obese-women-a-double-blind-randomized-controlled-clinical-trial
#19
Sajjad Roosta, Mina Kharadmand, Farshad Teymoori, Mehdi Birjandi, Ahmad Adine, Ebrahim Falahi
AIMS: The aim of this study was to investigate effect of vitamin D supplementation on anthropometric indices among women with overweight and obesity. METHODS: This double blind randomize clinical trial was conducted on 66 overweight and obese women. Those in intervention group received oral supplement of vitamin D 50,000 IU (1250 mcg) per 25 day and in control group participants received placebo for 3 months. Anthropometric indices were measured before and after 3 months intervention...
July 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29615173/outcome-of-chronic-kidney-disease-patients-on-the-basis-of-referral-to-nephrologist-a-one-year-follow-up-study
#20
Muhammad Anees, Yasir Hussain, Muhammad Ibrahim, Irfan Ilahi, Sajjad Ahmad, Khushbakht Isma Asif, Amina Jameel
OBJECTIVE: To determine the outcome of chronic kidney disease (CKD) patients presenting for dialysis on the basis of referral to nephrologist. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Nephrology Department of King Edward Medical University/Mayo Hospital, Lahore, from January 2014 to January 2016. METHODOLOGY: All patients who were presented in nephrology outpatients department and with the indication of dialysis were included in study...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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