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Steroid AND Respiratory

Márcio Shigueaki Mito, Adriano Antonio Silva, Fernanda Lima Kagami, Jéssica Dario de Almeida, Gislaine Cristiane Mantovanelli, Mauro Cezar Barbosa, Kátia Aparecida Kern-Cardoso, Emy Luiza Ishii-Iwamoto
The exogenous applications of plant hormones and their analogues have been exploited to improve crop performance in the field. Protodioscin is a saponin whose steroidal moiety in its structure has some similarities with plant steroidal hormones brassinosteroids. To test the possibility that protodioscin acts as an agonist or antagonist of brassinosteroids or other plant growth regulator, in this work, we compared the responses of the weed species Bidens pilosa L. to treatment with protodioscin, brassinosteroids, auxins and abscisic acid (ABA)...
October 19, 2018: Plant Biology
Bin Wu, Ting Xu, Youping Li, Xi Yin
BACKGROUND: Familial Mediterranean fever, a hereditary auto-inflammatory disease, mainly affects ethnic groups living in the Mediterranean region. Early studies reported colchicine as a potential drug for preventing attacks of familial Mediterranean fever. For those people who are colchicine-resistant or intolerant, drugs such as rilonacept, anakinra, canakinumab, etanercept, infliximab, thalidomide and interferon-alpha might be beneficial. This is an updated version of the review. OBJECTIVES: To evaluate the efficacy and safety of interventions for reducing inflammation in people with familial Mediterranean fever...
October 19, 2018: Cochrane Database of Systematic Reviews
Alfred Maroyi
The bark, leaves, and roots of Albizia adianthifolia are highly sought after in tropical Africa as herbal medicines. Therefore, the aim of this study was to review the botany, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia so as to provide baseline data required for evaluating the therapeutic potential of the species. Information on the botanical profile, medicinal uses, phytochemistry, and pharmacological properties of A. adianthifolia was undertaken using databases such as ScienceDirect, SciFinder, Pubmed, Google Scholar, Medline, SCOPUS, EThOS, ProQuest, OATD, and Open-thesis...
2018: TheScientificWorldJournal
Murat Türk, Sakine Nazik Bahçecioğlu, Nuri Tutar, Fatma Sema Oymak, İnci Gülmez, İnsu Yılmaz
OBJECTIVES: Omalizumab is a monoclonal antibody that is used as add-on therapy for treating moderate-to-severe persistant atopic asthma in patients with persistant symptoms and frequent exacerbations, despite step 4 treatment according to GINA guidelines. Real-life studies on omalizumab treatment are limited in Turkey. Thus, the present study aims to assess the clinical efficacy and treatment outcomes of omalizumab in patients with atopic severe persistant asthma. MATERIALS AND METHODS: Patients with atopic severe persistant asthma who were treated with omalizumab between 2009 and 2017 were retrospectively evaluated...
September 13, 2018: Turkish Thoracic Journal
Margherita Nosadini, Shekeeb S Mohammad, Irene Toldo, Stefano Sartori, Russell C Dale
BACKGROUND: Available data on mycophenolate mofetil (MMF), azathioprine (AZA) and methotrexate (MTX) for paediatric-onset anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is limited. METHODS: Systematic literature review on patients treated with MMF/AZA/MTX for paediatric-onset anti-NMDARE, with focus on modes of use, efficacy and safety. RESULTS: 87 patients were included (age at onset median 11 years, range 0.8-18 years; 69% females)...
September 27, 2018: European Journal of Paediatric Neurology: EJPN
Elisabetta Zucchi, Francesco Cavallieri, Giada Giovannini, Francesca Antonelli, Maria Teresa Mascia, Roberta Bedin, Jessica Mandrioli
A 64 years-old woman presented subacute onset distal paraesthesia concurrently with cold-induced urticaria, a rare form of physical urticaria. Both the disturbances developed a fortnight after an upper respiratory tract infection. EMG confirmed an exclusively sensory polyneuropathy, with prolongation of distal latencies and reduction of amplitudes. Anti-GQ1b and anti-GT1a antigangliosides antibodies were found in serum. The clinical workout included CSF analysis, cryoglobulin and paraprotein search, neurotropic infective agents, neoplastic markers and extensive autoimmune disease antibodies analysis, all of which resulted negative...
October 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Hyo-Jung Kim, Won Hyuk Lee, Nari Jeong, Jae Ha Lee, Jin Han Park, Hang Jea Jang, Hyun-Kuk Kim
RATIONALE: Standard treatment of lipoid pneumonitis remains unclear. This study reports a case of kerosene pneumonitis successfully treated with systemic steroid and segmental bronchoalveolar lavage (BAL). PATIENT CONCERNS: A 30-year-old woman referred to our hospital because of worsening of respiratory symptoms and fever despite antibiotic therapy following accidental ingestion of kerosene. She had no underlying disease. DIAGNOSES: Chest CT scan showed necrotic consolidation, ground glass opacity (GGO), bronchial wall thickening in the right middle/lower lobe (RML/RLL) and right pleural effusion...
October 2018: Medicine (Baltimore)
Monica Tang, Robert J Henderson, Janet T Holbrook, Loretta G Que, Anne M Mathews, Robert A Wise, Anne E Dixon, Stephen P Peters, Linda Rogers, Lewis J Smith, W Gerald Teague, Jason E Lang
BACKGROUND: Since respiratory tract infections (RTIs) precede most exacerbations, better understanding of the risk factors of RTIs and RTI-associated exacerbations in patients with asthma is a pressing public health need. Obesity in patients with asthma is associated with worse asthma control and higher asthma-associated healthcare utilization but its effect on RTI risk is unknown. OBJECTIVE: We aimed to study the association of BMI classification on the risk of self-reported RTIs and related asthma morbidity among adults and children with asthma...
October 9, 2018: Journal of Allergy and Clinical Immunology in Practice
Katrine Feldballe Bernholm, Anne-Sophie Homøe, Howraman Meteran, Camilla Bjørn Jensen, Celeste Porsbjerg, Vibeke Backer
Asthma is characterised by inflammation and respiratory symptoms. Current asthma treatment is based on severity of asthma symptoms only. Exhaled nitric oxide fraction ( F eNO ) is not recommended by the Global Initiative for Asthma guidelines. The aim was to compare the usefulness of a F eNO guided versus symptom-based treatment in achieving improved asthma control assessed by airway hyperresponsiveness (AHR). 80 asthmatic patients were included in a double-blinded, parallel, randomised controlled trial with follow-up visits after 8, 24 and 36 weeks...
October 2018: ERJ Open Research
Kazuko Uto, Shigehisa Yanagi, Hironobu Tsubouchi, Nobuhiro Matsumoto, Masamitsu Nakazato
The concurrence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) disease, known as double-positive disease, is rare, but it occurs at a much higher frequency than expected by chance. Double-positive disease has an aggressive clinical course, with no optimal treatment strategy. Here we describe a patient with steroid-refractory double-positive disease who was treated successfully with the addition of plasma exchange (PE) and cyclophosphamide (CPA)...
2018: Respiratory Medicine Case Reports
Ernesto Crisafulli, Enric Barbeta, Antonella Ielpo, Antoni Torres
Background: Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital...
2018: Multidisciplinary Respiratory Medicine
Oscar Mancera-Páez, Gustavo C Román, Rodrigo Pardo-Turriago, Yhojan Rodríguez, Juan-Manuel Anaya
We review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barré syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute encephalitis [acute disseminated encephalomyelitis] (ADEM+GBS) affecting a 24-year-old woman from Cúcuta, Colombia, who developed acute Zika virus (ZIKV) infection confirmed by serum reverse transcriptase-polymerase chain reaction (RT-PCR) and convalescent ZIKV IgG antibodies...
September 26, 2018: Journal of the Neurological Sciences
Khalid Alfakeekh, Mohammed Azar, Banan Al Sowailmi, Saja Alsulaiman, Salwa Al Makdob, Aamir Omair, Esam Albanyan, Manal Saleh Bawazeer
INTRODUCTION: Patients with primary childhood nephrotic syndrome (PCNS) develop alterations in their cellular and humoral immunity that predisposes them to the development of infection, and lead them to have frequent relapses. Also, infection could be significantly enhanced by immunosuppressive agents. This study aims to estimate the immunosuppressive burden, rate of infection and identify possible risk factors in PCNS requiring hospitalization. METHODOLOGY: A cross-sectional study of hospitalized children≤14years of age diagnosed with PCNS in King Abdul-Aziz Medical City, Riyadh from January 2003 to December 2013...
September 29, 2018: Journal of Infection and Public Health
Anthony D Vinson, Reinaldo Rampolla-Selles, E Shannon Cooper, Caroline R Alquist
Background: Acute rejection of lung allografts is an important contributor to morbidity and mortality in the transplant patient population, resulting in the dysfunction and destruction of the graft by the host's immune system via cellular or antibody-mediated mechanisms. Acute cellular rejection (ACR) is more common and better characterized than antibody-mediated rejection, which to date lacks any widely agreed upon, standardized set of diagnostic criteria. We present a case of AMR attributable to a rare phenomenon, non-human leukocyte antigen (HLA) antibodies...
2018: Ochsner Journal
Shushi Fujisato, Takashi Urushibara, Hajime Kasai, Daisuke Ishi, Kazuhiro Inafuku, Yoshikatsu Fujinuma, Toshihide Shinozaki
BACKGROUND Herpes zoster is caused by the reactivation of the varicella zoster virus (VZV) and usually presents with vesicular skin lesions with a dermatomal distribution. Disseminated herpes zoster (DHZ) infection is characterized by non-dermatomal skin eruptions, often with involvement of other organs, and occurs in immunocompromised patients. CASE REPORT A 69-year-old man who was treated with prednisolone for amiodarone-associated interstitial lung disease, presented with seizures and altered consciousness...
October 1, 2018: American Journal of Case Reports
Seher Erdoğan, Sevinç Kalın
Hashimoto encephalopathy (HE) is a steroid-responsive, acute or subacute encephalopathy, characterised by autoimmune thyroiditis associated with elevated antithyroid antibody titres. An 11-year-old girl was admitted to the Department of Paediatrics with generalised tonic-clonic seizures, left facial paralysis and right hemiparesis. Ceftriaxone and acyclovir were applied, and methyl prednisolone 2 mg kg-1 day-1 was administered orally. The hemiparesis improved on the 3rd day of treatment, but the facial paralysis persisted into the 15th day...
September 2018: Turkish Journal of Anaesthesiology and Reanimation
Carlos Kofman, Alejandro Teper
Background: In vitro and scintigraphic studies have suggested that effectiveness of metered-dose inhalers (MDI) with nonvalved spacers (NVS) is similar to that of MDI with valved holding chambers (VHC). Nevertheless, there are no clinical studies that compare these techniques in long-term treatment with inhaled steroids in young children with recurrent wheezing and risk factors for asthma. Objective: To compare the efficacy of a long-term treatment with Fluticasone Propionate administered by an MDI through both type of spacers, with and without valves, in young children with recurrent wheezing and risk factors for asthma...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Emiko Kono, Masako Hiramatsu, Toshihiro Kobayashi, Ichiro Tsunematsu, Yoshiro Imai, Junna Sakane, Yusuke Suzuki
A 78-year-old man who developed metastatic liver and lung cancer after undergoing surgery for rectal and sigmoid colon cancer was treated with TAS-102 as fourth-line chemotherapy. He developed high fever and dyspnea and was referred to the emergency room 16 days after receiving the first course of TAS-102. Chest X-ray and computed tomography examinations showed bacterial pneumonia. He was treated with tazobactam/piperacillin, but developed severe dyspnea 4 days later. A diffuse ground-glass appearance was observed in both the lungs on chest X-ray examination, and drug-induced interstitial pneumonitis was suspected...
September 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Akshata Huddar, Parayil S Bindu, Madhu Nagappa, Rose D Bharath, Sanjib Sinha, Pavagada S Mathuranath, Arun B Taly
Background: Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare disorder; there is limited experience regarding its clinical course and therapeutic response. Aims and Objectives: To describe the clinical profile, investigations, and therapeutic outcome in pediatric OMAS. Patients and Methods: Fourteen children (age: 27.1 ± 7 months; male: female = 1:2.3) suffering from OMAS seen over a period of 10 years (2006-2015) were included in the study...
September 2018: Neurology India
Małgorzata Stańczyk, Irena Bałasz-Chmielewska, Beata Lipska-Ziętkiewicz, Marcin Tkaczyk
BACKGROUND: Treatment of steroid resistant nephrotic syndrome is still a challenge for physicians. There are a growing number of studies exploring genetic background of steroid-resistant glomerulopathies. CASE DIAGNOSIS/TREATMENT: We present the case of a 4-year-old girl with steroid-resistant glomerulopathy due to a COQ6 defect with no additional systemic symptoms. The disease did not respond for second-line therapy with calcineurin inhibitor, but it remitted completely after oral treatment with 30 mg/kg/d of coenzyme Q10 (CoQ10)...
September 19, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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