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Steroid AND Respiratory

Jong Sook Park, Ji Hye Son, Choon Sik Park, Hun Soo Chang
For the past three decades, a large number of genetic studies have been performed to examine genetic variants associated with asthma and its subtypes in hopes of gaining better understanding of the mechanisms underlying disease pathology and to identify genetic biomarkers predictive of disease outcomes. Various methods have been used to achieve these objectives, including linkage analysis, candidate gene polymorphism analysis, and genome-wide association studies (GWAS); however, the degree to which genetic variants contribute to asthma pathogenesis has proven to be much less significant than originally expected...
January 2019: Yonsei Medical Journal
Lara El Khoury, Richard Furie
Human granulocytic anaplasmosis (HGA) is a tickborne rickettsial disease caused by the bacterium Anaplasma phagocytophilum. Reported cases have increased with the highest incidence in the Northeast. To our knowledge, this is the first report of anaplasmosis associated with an inflammatory arthritis. A 64-year-old man, with a history of Crohn's disease controlled on budesonide, presented to the emergency room in August 2017 with a week history of headache, sore throat, fever, myalgias, rash, and joint pain. There was no clinical evidence of active Crohn's disease...
December 11, 2018: Clinical Rheumatology
Farnad Imani, Poupak Rahimzadeh, Hamid-Reza Faiz, Shiva Nowruzina, Asadolla Shakeri, Mohammad Ghahremani
Background: Paracetamol and non-steroidal anti-inflammatory drugs (e.g. ketorolac) can be considered for mild to moderate post-caesarean pain. As a selective α-2 agonist adrenergic receptor, dexmedetomidine has analgesic and sedative effects without causing respiratory depression. Objectives: This study aimed to evaluate the effects of adding dexmedetomidine to paracetamol or ketorolac on post-caesarean pain and the associated complications thereof. Methods: Sixty pregnant women, who were candidates for caesarean section with spinal anesthesia, were randomly assigned to either of two groups of 30 patients...
October 2018: Anesthesiology and Pain Medicine
Alpana Waghmare, Hu Xie, Jane Kuypers, Mohamed L Sorror, Keith R Jerome, Janet A Englund, Michael Boeckh, Wendy M Leisenring
Human rhinovirus lower respiratory tract infection is associated with mortality following hematopoietic cell transplantation; however, risk factors for lower respiratory tract infection are not well characterized. We sought to develop a risk score for progression to lower respiratory tract infection from upper respiratory tract infection in hematopoietic cell transplantation recipients. Risk factors for lower respiratory tract infection within 90 days were analyzed using Cox regression among hematopoietic cell transplantation recipients with rhinovirus upper respiratory tract infection between 1/2009-3/2016...
December 8, 2018: Biology of Blood and Marrow Transplantation
Han Ni, Soe Moe, Zay Soe, Kay Thi Myint, K Neelakantan Viswanathan
BACKGROUND: Several dual bronchodilator combinations of long-acting beta2 -agonist (LABA) and long-acting muscarinic antagonist (LAMA) have been approved for treatment of stable chronic obstructive pulmonary disease (COPD). The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest the use of LABA/LAMA combinations in people with group B COPD with persistent symptoms, group C COPD with further exacerbations on LAMA therapy alone and group D COPD with or without inhaled corticosteroids (ICS)...
December 11, 2018: Cochrane Database of Systematic Reviews
Gustavo F Wandalsen, Renata G Dias, Herberto J Chong-Neto, Nelson Rosário, Lillian Moraes, Neusa F Wandalsen, Décio Medeiros, Ana Caroline Della Bianca, Marilyn Urrutia-Pereira, Jennifer Avila, Patrícia P Jorge, Dirceu Solé
Background: TRACK (Test for Respiratory and Asthma Control in Kids) questionnaire is an instrument developed and validated in English to evaluate the control of respiratory symptoms in children under 5 years of age. Objective: To validate the Portuguese version of the TRACK questionnaire. Methods: The validation was done in an observational, prospective and multicenter evaluation (six centers in Brazil) in children with recurrent respiratory symptoms...
2018: World Allergy Organization Journal
Ajay Sheshadri, Roy F Chemaly, Amin M Alousi, Pankil K Shah, Gabriela Rondon, Lara Bashoura, Joumana Kmeid, Jacques Azzi, David W Blanco, Maryam Kaous, Burton F Dickey, Richard E Champlin, Dimpy P Shah
INTRODUCTION: Pulmonary impairment predicts increased mortality in many settings, and respiratory viral infection (RVI) causes considerable morbidity and mortality in allogeneic hematopoietic cell transplant recipients (allo-HCT). We hypothesized that pulmonary impairment following respiratory viral infection, defined as a decline of forced expiratory volume in 1 second values by ≥10%, may identify allo-HCT recipients at high risk for mortality. METHODS: We studied all allo-HCT recipients at our institution who had RVI with respiratory syncytial virus, parainfluenza virus, or influenza from 2004-2013 and had pre-RVI and post-RVI pulmonary function tests...
December 3, 2018: Biology of Blood and Marrow Transplantation
Amna Rehman, Fatima Amin, Saleha Sadeeqa
Among respiratory problems, asthma is one of the most apidly growing disorder which has victimised about onethird of the world's population and almost 2.5 million patients die annually as a result of severe exacerbation. Asthmatic patients most of the time fail to receive maximum benefits from the therapy because of drugrelated problems, side effects of steroid medication and special skill required for the administration technique of drug inhalation. The current review was planned to highlight the most frequent problems of asthmatic patients and their possible management suggested during the last few years...
December 2018: JPMA. the Journal of the Pakistan Medical Association
Arshad Khushdil, Shehla Baqai, Madiha Ahmed, Zeeshan Ahmed
OBJECTIVE: To determine the effect of dexamethasone administration to women between 37 to 39 weeks of gestation on neonatal outcome in terms of respiratory morbidity and the need for NICU admission. STUDY DESIGN: An experimental study. PLACE AND DURATION OF STUDY: Department of Obstetrics and Department of Neonatology, Military Hospital, Rawalpindi, Pakistan, from February to July 2017. METHODOLOGY: Women with singleton pregnancies, undergoing elective cesarean section between 37-39 weeks...
December 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Adedapo Kiladejo, Marina Palumbo, Tanya M Laidlaw
No abstract text is available yet for this article.
November 24, 2018: Journal of Allergy and Clinical Immunology in Practice
Aamer Imdad, Maribeth R Nicholson, Emily E Tanner-Smith, Joseph P Zackular, Oscar G Gomez-Duarte, Dawn B Beaulieu, Sari Acra
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, relapsing disease of the gastrointestinal tract that is thought to be associated with a complex interplay between microbes and the immune system, leading to an abnormal inflammatory response in genetically susceptible individuals. Dysbiosis, characterized by the alteration of the composition of the resident commensal bacteria in a host compared to healthy individuals, is thought to play a major role in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD), two subtypes of IBD...
November 13, 2018: Cochrane Database of Systematic Reviews
Murat Acat, Elif Tanrıverdi, Efsun Gonca Uğur Chousein, Barış Demirkol, Binnaz Zeynep Yıldırım, Demet Turan, Mehmet Akif Özgül, Erdoğan Çetinkaya
Introduction: Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare disease affecting young smokers. It is more common between the ages of 20-40 and equals the male/female ratio. Lung biopsy is the most useful methods for diagnosis. The first treatment is to quit smoking. Corticosteroids or chemotherapeutic agents can be used in severe progressive cases despite of quiting smoking. The patients with PLCH followed in our clinic were assessed with general clinical features in the light of the literature...
September 2018: Tüberküloz Ve Toraks
Yu Shionoya, Hajime Kasai, Jiro Terada, Mitsuhiro Abe, Yusuke Takeda, Emiko Sakaida, Nobuhiro Tanabe, Koichiro Tatsumi
BACKGROUND Cytomegalovirus (CMV) pneumonia is common in immunocompromised patients with hematological malignancies. Although the spectrum of illness caused by CMV is well-documented in immunocompromised patients, the clinical course and evolution of lung changes after initiation of antiviral therapy remain unclear. CASE REPORT We present the cases of 3 patients with leukemia who developed CMV pneumonia following cord blood transplantation and who presented with distinctive features on chest computed tomography (CT)...
November 23, 2018: American Journal of Case Reports
Yun-Ru Lai, Jr-Rung Lin, Wen-Neng Chang, Nai-Wen Tsai, Chih-Cheng Huang, Hung-Chen Wang, Yu-Jih Su, Wei-Che Lin, Ben-Chung Cheng, Chih-Min Su, Sheng-Yuan Hsiao, Chun-En Kuo, Cheng-Hsien Lu
BACKGROUND: Although corticosteroids are an effective anti-inflammatory adjuvant therapy, the role of adjunctive steroid therapy in treating adult bacterial meningitis in Taiwan remains controversial. METHODS: Cases of acute bacterial meningitis were identified from the annual hospitalization discharge claims of the National Health Insurance Research Database using International Classification of Diseases, Ninth Revision codes from January 2000 to December 2013...
November 19, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Ketan Yerneni, John F Burke, Noah Nichols, Lee A Tan
Vocal cord dysfunction as a result of recurrent laryngeal nerve palsy (RLNP) is a known complication following anterior cervical discectomy and fusion (ACDF). RLNP occurs typically due to neuropraxia caused by intraoperative compression or traction on the nerve, and less commonly from direct nerve injury intraoperatively in the setting of anterior cervical spine surgery. Patients with RLNP typically present with hoarseness immediately after surgery due to unilateral vocal cord paralysis. However, in rare cases there is a late-onset, progressive development of RLNP that may potentially lead to permanent vocal cord paralysis or respiratory failure...
November 19, 2018: World Neurosurgery
Oladapo A Adewuya, Rasaaq A Adebayo, Adeola I Ajibade, Gbenga J Odunlami, Anthony O Akintomide, Suraj A Ogunyemi, Olufemi E Ajayi, Adebola O Adetiloye, Adeleye D Omisore, Oladipo A Olanipekun, Adeyinka O Owolabi, Ifeoluwa Amjo, Olumide A Akinyele, Abayomi O Bamgboje, Michael O Balogun
Background: Mixed connective tissue disease (MCTD; also known as Sharp's syndrome) is a rare autoimmune inflammatory disorder characterized by high titer of U1 ribonucleoprotein (U1RNP) antibody and clinical and serological overlap of systemic lupus erythematosus, systemic sclerosis, and polymyositis. The diagnosis is based on clinical and serological factors in criteria such as Alarcon-Segovia, Khan, Kusakawa, and Sharps. Cardiac disease can be a complication of connective tissue disease (CTD)...
2018: International Medical Case Reports Journal
Katherine D Culbreath, Alejandro V Garcia, Ira L Leeds, Mitchell R Ladd, Todd Crawford, Emily Boss, Daniel S Rhee
INTRODUCTION: Complete tumor resection of primary malignant liver tumors offers the best chance of survival. However, many of these children may experience anemia and failure to thrive. This study analyzes the association of preoperative anemia and nutritional support with outcomes in children undergoing major resection of primary malignant liver tumors. METHODS: Using the National Surgical Quality Improvement Program Pediatric database from 2012 to 2015, children undergoing major liver resections for primary malignant hepatic tumors were selected...
December 2018: Journal of Surgical Research
Regev Cohen, Talya Finn, Frida Babushkin, Maurice Shapiro, Martina Uda, Tamar Grossman
BACKGROUND: We describe a patient with Strongyloides stercoralis hyperinfection associated with Streptococcus pyogenes and with streptococcal toxic shock syndrome. To the best of our knowledge this association has not been previously described. CASE PRESENTATION: A 78 year-old Israeli man, who was born in Iraq but lived in Israel for 66 years, presented with multi-organ failure including acute kidney and hepatic injury, coagulopathy, and lactic acidosis. He had a medical history including aortic valve replacement, diabetes mellitus, spinal stenosis, and low back pain treated with repeated local steroid injections...
November 22, 2018: Journal of Medical Case Reports
Patricia Liu, Gregory P Ranches, Jeffrey A Gold
BACKGROUND: Severe systemic reactions resembling septic shock have been described following trimethoprim-sulfamethoxazole (TMP-SMX) administration. Nearly all cases described in the literature occurred in HIV-infected patients. CASE PRESENTATION: We present a 42-year-old woman with a history of systemic lupus erythematosus (SLE) who was admitted to the Intensive Care Unit (ICU) twice with fever and circulatory shock after taking a dose of TMP-SMX 800-160 mg. She had no respiratory distress, urticarial rash or eosinophilia on presentation...
November 20, 2018: BMC Pharmacology & Toxicology
Padmastuti Akella, Sundaravadivel Loganathan, Vishal Jindal, Jamal Akhtar, Amos Lal
Introduction: Lung cancer is one of the most common cancers in the world and it is the leading cause of cancer-related deaths, among men and women, in the United States. In advanced non-small cell lung cancers, immune checkpoint inhibitors such as programmed cell death protein-1 inhibitors (PD-1 inhibitors) have become second-line therapy and have revolutionized the management in selective cases conferring better overall response rates and progression free survival. Methods: We present a case series and review of literature emphasizing this immune-related adverse events (irAEs) in patients with metastatic non-small cell lung cancer and esophageal cancer who were treated with Nivolumab as a second line therapeutic option...
2019: Respiratory Medicine Case Reports
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