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Steroid AND Respiratory

Serra Sürmeli-Döven, Ali Delibaş, İclal Gürses, Uğur Raşit Kayacan, Banu Coşkun-Yılmaz, Kaan Esen, Emine Korkmaz, Fatih Özaltın
Sürmeli-Döven S, Delibaş A, Gürses İ, Kayacan UR, Coşkun-Yılmaz B, Esen K, Korkmaz E, Özaltın F. Hemolytic uremic syndrome and IgA nephropathy in a child: Coincidence or not? Turk J Pediatr 2018; 60: 81-85. A previously healthy 18-month old boy, presenting with diarrhea, anemia, thrombocytopenia and acute renal failure was admitted to our hospital. Hemolytic uremic syndrome (HUS) was diagnosed with his clinical and laboratory findings. His stool was negative for Shiga toxin producing E. coli (STEC)...
2018: Turkish Journal of Pediatrics
Hojun Lee, Kijeong Kim, Boa Kim, Junchul Shin, Sudarsan Rajan, Jingwei Wu, Xiongwen Chen, Michael D Brown, Sukho Lee, Joon-Young Park
KEY POINTS: Referring to the muscle memory theory, previously trained muscles acquire strength and volume much faster than naive muscles. Using extreme experimental models such as synergist ablation or steroid administration, previous studies have demonstrated that the number of nuclei increases when a muscle becomes enlarged, which serves as a cellular muscle memory mechanism for the muscle. In the present study, we found that, when rats were subjected to physiologically relevant resistance training, the number of myonuclei increased and was retained during a long-term detraining period...
August 12, 2018: Journal of Physiology
Brigitte Kazzi, David Lederer, Emilio Arteaga-Solis, Anjali Saqi, Wendy K Chung
Surfactant protein C (SP-C) deficiency causes diffuse lung disease with variable prognosis and severity that usually presents in infancy. We present the case of a patient with diffuse lung disease who was successfully treated with hydroxychloroquine and steroids in infancy, who presented again as a young adult with respiratory symptoms. Exome sequencing identified a novel de novo SFTPC mutation (c.397A > C p.S133R). Mutated SP-C accumulates and leads to injury of alveolar type II cells, which normally replenish alveolar type I cells after injury...
2018: Respiratory Medicine Case Reports
Priyanka Krishna, Prasan Kumar Panda, Sudarsan Hariprasad, Shiv Shankar Singh, S R Gedela
Respiratory distress is very uncommon as a presenting symptom of Chilaiditi syndrome. Furthermore, pneumonia is not documented with the syndrome, compromising further to the distress. We describe a middle-aged man, chronic alcoholic, recently diagnosed with liver cirrhosis, presented with a 1-year history of slowly progressive breathlessness. Recently, he developed mild-to-moderate hemoptysis and cough with aggravation of breathlessness. He did not have fever, chest pain, or orthopnea. He was cyanosed, requiring high-dose oxygen therapy...
March 2018: Journal of Family Medicine and Primary Care
Prashant Moon, N Jithendran
Invasive fungal infection in burn injury is caused by inoculation of fungal spore from patient skin, respiratory tract or from care giver. The risk factors for acquiring fungal infection in burns include age of burns, total burn size, full thickness burns, inhalational injury, prolonged hospital stay, late surgical excision, open dressing, central venous catheters, antibiotics, steroid treatment, long-term artificial ventilation, fungal wound colonization, hyperglycemic episodes and other immunosuppressive disorders...
May 2018: World Journal of Plastic Surgery
Arshia, Almas Jabeen, Aisha Faheem, Khalid Mohammed Khan, Shazia Shah, Shahnaz Perveen
BACKGROUND: Inflammation is a biological rejoinder of vascular tissues against destructive agents e.g. irritants, damaged cell or pathogens. During inflammation respiratory burst occur by activated phagocytes helps to destroy invading pathogens. Phagocytic cells such as neutrophils and macrophages are one of the major sources of reactive oxygen species (ROS) and nitric oxide (NO). Normally the redox environment is maintained by various antioxidant defense systems, however, these reactive oxygen species may be destructive and can lead to various pathological conditions...
August 5, 2018: Medicinal Chemistry
Laura J Spece, Eric M Epler, Lucas M Donovan, Matthew F Griffith, Margaret P Collins, Laura C Feemster, David H Au
RATIONALE: Hospital readmissions are an important cause of morbidity and mortality among patients with COPD. While comorbidities are associated with outcomes in COPD, it is unknown how they affect treatment choices. OBJECTIVE: We sought to examine whether comorbidity was associated with readmission, mortality, and delivery of in-hospital treatment for COPD exacerbations. METHODS: We performed a cohort study of veterans hospitalized with a COPD exacerbation to six Veterans Affairs hospitals between 2005-2011...
August 4, 2018: Annals of the American Thoracic Society
Alexandros Sotiriadis, George Makrydimas, Stefania Papatheodorou, John Pa Ioannidis, Emma McGoldrick
BACKGROUND: Infants born at term by elective caesarean section are more likely to develop respiratory morbidity than infants born vaginally. Prophylactic corticosteroids in singleton preterm pregnancies accelerate lung maturation and reduce the incidence of respiratory complications. OBJECTIVES: The objective of this review was to assess the effect of prophylactic corticosteroid administration before elective caesarean section at term, as compared to usual management without corticosteroids, in reducing neonatal respiratory morbidity and admission to special care with respiratory complications...
August 3, 2018: Cochrane Database of Systematic Reviews
Mikhail Kazachkov, Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Bat-El Bar-Aluma, Christy L Spalink, Erin P Barnes, Nancy E Amoroso, Stamatela M Balou, Shay Bess, Arun Chopra, Rany Condos, Ori Efrati, Kathryn Fitzgerald, David Fridman, Ronald M Goldenberg, Ayelet Goldhaber, David A Kaufman, Sanjeev V Kothare, Jeremiah Levine, Joseph Levy, Anthony S Lubinsky, Channa Maayan, Libia C Moy, Pedro J Rivera, Alcibiades J Rodriguez, Gil Sokol, Mark F Sloane, Tina Tan, Horacio Kaufmann
BACKGROUND: Familial dysautonomia (Riley-Day syndrome, hereditary sensory autonomic neuropathy type-III) is a rare genetic disease caused by impaired development of sensory and afferent autonomic nerves. As a consequence, patients develop neurogenic dysphagia with frequent aspiration, chronic lung disease, and chemoreflex failure leading to severe sleep disordered breathing. The purpose of these guidelines is to provide recommendations for the diagnosis and treatment of respiratory disorders in familial dysautonomia...
August 2018: Respiratory Medicine
Tyler Pickell, Jamie Donnelly, Francois Abi Fadel
Desquamative interstitial pneumonia (DIP) is a rare interstitial pneumonia often caused by smoking. DIP is typically regarded as a chronic disease, but acute DIP exacerbations can occur, and some have resulted in death. Factors that can provoke a DIP exacerbation are not well described in the literature. We present a case of a 58-year-old male with DIP, who after being treated successfully with smoking cessation and steroids for 7 months, required hospitalization for acute hypoxemic respiratory failure. This acute episode was very likely an exacerbation of his DIP after a smoking relapse period of 6 weeks prior to this acute presentation...
2018: Case Reports in Pulmonology
Giulia De Feo, Roberta Parente, Massimo Triggiani
PURPOSE OF REVIEW: Anaphylaxis is an acute medical emergency characterized by sudden presentation of life-threatening respiratory and cardiovascular symptoms. Rapid diagnosis of anaphylaxis is crucial to implement an appropriate treatment and management plan. However, mistakes in the diagnosis of anaphylaxis may occur because of the limited time during which the diagnosis must be made, the stressful environment of the emergency room, the often aspecific or incomplete clinical features of early anaphylaxis and the lack of useful laboratory markers...
July 19, 2018: Current Opinion in Allergy and Clinical Immunology
Mário Bruno Ribeiro de Oliveira Santos, Paulo Mergulhão
Severe drug-induced lung disease, resistant to steroids, is a dramatic situation due to the absence of therapeutic alternatives. We describe a case of vinorelbine-induced acute respiratory distress syndrome that did not respond to supportive care plus high-dose steroids. Cyclophosphamide pulse therapy was initiated with subsequent clinical and radiological improvement, allowing the patient to be discharged. We suggest that vinorelbine-induced lung toxicity is driven by a primarily immune-mediated mechanism and that it can respond favourably to immunosuppressive therapy...
October 2018: Respirology Case Reports
Ashley N Battarbee, Mark A Clapp, Kim A Boggess, Anjali Kaimal, Carrie Snead, Jay Schulkin, Sofia Aliaga
OBJECTIVE:  The objective of this study was to measure knowledge and practice variation in late preterm steroid use. STUDY DESIGN:  Electronic survey of American College of Obstetricians and Gynecologists (ACOG) members about data supporting the ACOG/Society for Maternal-Fetal Medicine (SMFM) recommendations and practice when caring for women with anticipated late preterm birth (PTB), 340/7 to 366/7 weeks. RESULTS:  Of 352 administered surveys, we obtained 193 completed responses (55%); 82...
July 17, 2018: American Journal of Perinatology
Sinem Koc-Günel, Ralf Schubert, Stefan Zielen, Martin Rosewich
BACKGROUND: Sputum induction is an important noninvasive method for analyzing bronchial inflammation in patients with asthma and other respiratory diseases. Most frequently, ultrasonic nebulizers are used for sputum induction, but breath-controlled nebulizers may target the small airways more efficiently. This treatment may produce a cell distribution similar to bronchoalveolar lavage (less neutrophils and more macrophages) and provide deeper insights into the underlying lung pathology...
July 13, 2018: BMC Pulmonary Medicine
Behiye Deniz Kosovali, Asiye Yavuz, Fatma Irem Yesiler, Mustafa Kemal Bayar
Melkersson-Rosenthal Syndrome (MRS) is a rare disease characterized by persistent or recurrent orofacial oedema, relapsing peripheral facial paralysis, and furrowed tongue. Pathologically, granulomatosis is responsible for oedema of face, labia, oral cavity, and facial nerve. We present a patient with MRS admitted to our hospital with acute respiratory distress syndrome (ARDS). 45-year-old woman was admitted to an emergency department with dyspnea and swelling on her hands and face. She was intubated because of ARDS and accepted to intensive care unit (ICU)...
2018: Case Reports in Neurological Medicine
Darsana Viswam, Simon Trotter, P Sherwood Burge, Gareth I Walters
A young female vaper presented with insidious onset cough, progressive dyspnoea on exertion, fever, night sweats and was in respiratory failure when admitted to hospital. Clinical examination was unremarkable. Haematological tests revealed only thrombocytopenia, which was long standing, and her biochemical and inflammatory markers were normal. Chest radiograph and high-resolution CT showed diffuse ground-glass infiltrates with reticulation. She was initially treated with empirical steroids and there was improvement in her oxygenation, which facilitated further tests...
July 6, 2018: BMJ Case Reports
Rieko Sakamoto, Shiro Matsumoto, Hiroshi Mitsubuchi, Kimitoshi Nakamura
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease in children, with unknown etiology. The classical clinical triad is hemoptysis, hypochromic anemia and diffuse parenchymal infiltrations on chest X-ray. Liposteroid dexamethasone palmitate, which was developed in Japan, has shown good efficacy for IPH. We present the case of a patient with IPH, who suffered from a life-threatening respiratory dysfunction, and was rescued by a trial administration of liposteroid with methylprednisolone (mPSL). A 6-year-old girl was admitted to our hospital for repeated dyspnea and blood-stained sputum...
2018: Respiratory Medicine Case Reports
Woong Kim, Yoon Cho, Mi-Kyung Song, Jung-Hee Lim, Jin Young Kim, Myung Chan Gye, Jae-Chun Ryu
Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is a common cause of several respiratory diseases. In recent years, several studies have suggested that PM2.5 can influence diverse diseases, such as respiratory diseases, cardiovascular diseases, metabolic diseases, dementia, and female reproductive disorders, and unhealthy birth outcomes. In addition, several epidemiological studies have reported that adverse health effects of PM2.5 can differ depending on regional variations...
July 5, 2018: Environmental Toxicology
Stefan Wöhrl
Background: Adverse drug reactions (ADR) to analgesics (i.e., non-steroidal anti-inflammatory drug hypersensitivity, NSAID-HS) are one of the most common ADR, affecting approximately 1.6% of all patients. Despite the fact that they are common, they still pose a diagnostic challenge. Methods: This article is an overview of selected scientific articles and is based on research in PubMed, specialist databases, and guidelines. Results: Approximately 80% of side effects are pharmacologically predictable and are classified as type A reactions, such as abdominal pain and bleeding events...
2018: Allergo Journal International
Martina Persson, Prakesh S Shah, Franca Rusconi, Brian Reichman, Neena Modi, Satoshi Kusuda, Liisa Lehtonen, Stellan Håkansson, Junmin Yang, Tetsuya Isayama, Marc Beltempo, Shoo Lee, Mikael Norman
Importance: Diabetes in pregnancy is associated with a 2-times to 3-times higher rate of very preterm birth than in women without diabetes. Very preterm infants are at high risk of death and severe morbidity. The association of maternal diabetes with these risks is unclear. Objective: To determine the associations between maternal diabetes and in-hospital mortality, as well as neonatal morbidity in very preterm infants with a birth weight of less than 1500 g. Design, Setting, Participants: This retrospective cohort study was conducted at 7 national networks in high-income countries that are part of the International Neonatal Network for Evaluating Outcomes in Neonates and used prospectively collected data on 76 360 very preterm, singleton infants without malformations born between January 1, 2007, and December 31, 2015, at 24 to 31 weeks' gestation with birth weights of less than 1500 g, 3280 (4...
July 2, 2018: JAMA Pediatrics
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