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Screening colonoscopy interval

Aasma Shaukat, Nabiha Shamsi, Jeremiah Menk, Timothy R Church, Jeffery Rank, Joshua Colton
BACKGROUND & AIMS: Accurate sizing of polyps and improving adenoma detection rates (ADR) are important goals for high-quality colonoscopy. Surveillance intervals are based on accurate sizing of polyps. There are no clinical tools or interventions that have demonstrated improvement in both these metrics. We investigated the efficacy of a simple, low-cost intervention, based on use of polyp sizing posters to improve measurements of polyps and increase ADRs during colonoscopy at a large gastroenterology community practice...
October 9, 2018: Clinical Gastroenterology and Hepatology
Elizabeth Hatfield, Jane S Green, Michael O Woods, Geoff Warden, Patrick S Parfrey
BACKGROUND: Hereditary Non-Polyposis Colorectal cancer is caused by Lynch Syndrome (LS; an autosomal dominant condition) or by Familial Colorectal Cancer Type-X (FCCTX; a condition of high family risk that fulfills Amsterdam criteria). The lifetime risk of developing colorectal cancer (CRC) in FCCTX family members is high and CRC occurs later than in LS. METHODS: To determine the impact of primary prevention colonoscopic screening in asymptomatic first-degree relatives of incident CRC cases in 20 families with FCCTX, we compared cancer incidence and survival in 79 males and 83 females, assumed to be at 50% risk of inheriting a genetic CRC susceptibility factor, who entered screening to an unscreened control group from the families, matched for age at entry into screening and for sex...
October 9, 2018: Molecular Genetics & Genomic Medicine
Manuel Zorzi, Cesare Hassan, Giulia Capodaglio, Elena Narne, Anna Turrin, Maddalena Baracco, Antonella Dal Cin, Annarita Fiore, Giancarla Martin, Alessandro Repici, Douglas Rex, Massimo Rugge
Background: Short-term studies have reported that the fecal immunochemical test (FIT) is less accurate in detecting proximal than distal colorectal neoplasia. Objective: To assess the long-term detection rates for advanced adenoma and colorectal cancer (CRC), according to anatomical location. Design: Retrospective study. Setting: Population-based, organized screening program in the Veneto region of Italy. Participants: Persons aged 50 to 69 years who completed 6 rounds of FIT screening...
October 2, 2018: Annals of Internal Medicine
Haim Shirin, Beni Shpak, Julia Epshtein, John Gásdal Karstensen, Arthur Hoffman, Rogier de Ridder, Pier Alberto Testoni, Sauid Ishaq, Acquisition Of Data, D Nageshwar Reddy, Seth A Gross, Helmut Neumann, Martin Goetz, Dov Abramowich, Menachem Moshkowitz, Meir Mizrahi, Peter Vilmann, Johannes Wilhelm Rey, Silvia Sanduleanu-Dascalescu, Edi Viale, Hrushikesh Chaudhari, Mark B Pochapin, Michael Yair, Mati Shnell, Shaul Yaari, Jakob Westergren Hendel, Daniel Teubner, Roel M M Bogie, Chiara Notaristefano, Roman Simantov, Nathan Gluck, Eran Israeli, Trine Stigaard, Shay Matalon, Alexander Vilkin, Ariel Benson, Stine Sloth, Amit Maliar, Amir Waizbard, Harold Jacob, Peter Thielsen, Eyal Shachar, Shmuel Rochberger, Tiberiu Hershcovici, Julie Isabelle Plougmann, Michal Braverman, Eduard Tsvang, Armita Armina Abedi, Yuri Brachman, Peter D Siersema, Ralf Kiesslich
BACKGROUND: Colorectal cancer (CRC) is largely preventable with routine screening and surveillance colonoscopy; however, interval cancers arising from precancerous lesions missed by standard colonoscopy (SC) still occur. Increased adenoma detection rate (ADR) has been found to be inversely associated with interval cancers. The G-EYE device comprises a reusable balloon integrated at the distal tip of a standard colonoscope, which flattens haustral folds, centralizes the colonoscope's optics and reduces bowel slippage...
September 28, 2018: Gastrointestinal Endoscopy
Helmut Neumann, Helmut Neumann Sen, Michael Vieth, Raf Bisschops, Florian Thieringer, Khan F Rahman, Thomas Gamstätter, Gian Eugenio Tontini, Peter R Galle
Objectives: A negative predictive value of more than 90% is proposed by the American Society of Gastrointestinal Endoscopy Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) statement for a new technology in order to leave distal diminutive colorectal polyps in place without resection. To our knowledge, no prior prospective study has yet evaluated the feasibility of the most recently introduced blue light imaging (BLI) system for real-time endoscopic prediction of polyp histology for the specific endpoint of leaving hyperplastic polyps in place...
August 2018: United European Gastroenterology Journal
Hassan Tariq, Muhammad Umar Kamal, Harish Patel, Ravi Patel, Muhammad Ameen, Shehi Elona, Maram Khalifa, Sara Azam, Aiyi Zhang, Kishore Kumar, Ahmed Baiomi, Danial Shaikh, Jasbir Makker
AIM: To evaluate the National Cancer Institute (NCI) Colorectal Cancer (CRC) Risk Assessment Tool as a predictor for the presence of adenomatous polyps (AP) found during screening or surveillance colonoscopy. METHODS: This is a retrospective single center observational study. We collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC risk. We calculated the AP prevalence across risk score quintiles, odds ratios of the prevalence of AP across risk score quintiles, area under curves (AUCs) and Youden's indexes to assess the optimal risk score cut off value for AP prevalence status...
September 14, 2018: World Journal of Gastroenterology: WJG
Yang Liu, Qing-Ke Huang, Xiu-Li Dong, Piao-Piao Jin
Background/Aims: To compare water exchange (WE) method with conventional air insufflation (AI) method for colonoscopy, evaluating the technical quality, screening efficacy, and patients' acceptance. Materials and Methods: Electronic databases were systematically searched for randomized controlled trials comparing WE colonoscopy with AI colonoscopy. The pooled data of procedure-associated and patient-related outcomes were assessed, using the weighted mean difference (WMD) with 95% confidence interval (CI) for continuous variables and relative risk (RR) with 95% CI for dichotomous variables, respectively...
September 18, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Donghyoun Lee, Kyung Uk Jung, Hyung Ook Kim, Hungdai Kim, Ho-Kyung Chun
Although periodontal disease and gastrointestinal tract health are closely associated, few studies have investigated whether periodontitis is a risk factor for colorectal adenoma. The aim of this study was to investigate whether there is an association between periodontitis and the risk of colorectal adenoma in asymptomatic healthy people.From January 2013 to October 2015, we retrospectively enrolled 42,871 patients who underwent health screening at Kangbuk Samsung Hospital in South Korea. Demographic and clinical data were collected before colonoscopy...
September 2018: Medicine (Baltimore)
Isabel Portillo, Isabel Idigoras, Isabel Bilbao, Eunate Arana-Arri, María José Fernández-Landa, Jose Luis Hurtado, Cristina Sarasaqueta, Luis Bujanda
Background and study aims  To compare the quality of colonoscopy in a population-based coordinated program of colorectal cancer screening according to type of hospital (academic or non-academic). Patients and methods  Consecutive patients undergoing colonoscopy after positive FIT (≥ 20 ug Hb/g feces) between January 2009 and September 2016 were prospectively included at five academic and seven non-academic public hospitals. Screening colonoscopy quality indicators considered were adenoma detection rate, cecal intubation rate, complications and bowel preparation quality...
September 2018: Endoscopy International Open
Jong Hee Hyun, Sang Jin Kim, Jung Hun Park, Gyung Ah Wie, Jeong-Seon Kim, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Dae Kyung Sohn
PURPOSE: The quality of bowel preparation is a major determinant of the quality of colonoscopy. This study evaluated lifestyle factors, including usual dietary style, associated with bowel preparation. METHODS: This retrospective study evaluated 1,079 consecutive subjects who underwent complete colonoscopy from December 2012 to April 2014 at National Cancer Center of Korea. Questionnaires on bowel preparation were completed by the subjects, with the quality of bowel preparation categorized as optimal (excellent or good) or suboptimal (fair, poor or inadequate)...
August 2018: Annals of Coloproctology
Gee Young Yun, Hyuk Soo Eun, Ju Seok Kim, Jong Seok Joo, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Shorter colonoscopic withdrawal time (CWT) has been associated with lower adenoma detection rate (ADR), which can increase the risk of interval colorectal cancer (ICC) that commonly arises in the right colon (RC). Therefore, a better ADR in the RC could decrease the incidence of ICC. We analyzed the relationship between CWT and ADR in the RC and entire colon.We retrospectively reviewed the patients who had undergone screening colonoscopy at Chungnam National University Hospital between March 2015 and February 2016...
August 2018: Medicine (Baltimore)
Clasine M de Klerk, Lisanne M Vendrig, Patrick M Bossuyt, Evelien Dekker
OBJECTIVES: Colorectal cancer (CRC) screening using fecal immunochemical tests (FIT) may reduce CRC-related mortality but its effectiveness is influenced by the limited accuracy of FIT. Identifying individuals at increased risk of a false FIT result could improve screening, but the available evidence is conflicting. We performed a systematic review and meta-analysis on risk factors for false-positive and false-negative FIT results in CRC screening. METHODS: A systematic search in MEDLINE, EMBASE, and Cochrane Library identified publications (before 29 January 2017) on risk factors (known at time of FIT invitation) associated with false FIT results (presence/absence of advanced neoplasia) in a CRC screening setting...
August 29, 2018: American Journal of Gastroenterology
Theodore A Tollivoro, Christopher D Jensen, Amy R Marks, Wei K Zhao, Joanne E Schottinger, Virginia P Quinn, Nirupa R Ghai, Ann G Zauber, Chyke A Doubeni, Theodore R Levin, Bruce Fireman, Charles P Quesenberry, Douglas A Corley
BACKGROUND AND AIMS: Postcolonoscopy colorectal cancers (PCCRCs) are those detected ≤10 years after an index colonoscopy negative for cancer, but modifiable risk factors are not well established in large, community-based populations. METHODS: We evaluated risk factors from the index colonoscopy for PCCRCs diagnosed 1 to 10 years after an index colonoscopy using a case-control design. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for potential confounders...
August 22, 2018: Gastrointestinal Endoscopy
Desmond Leddin, David A Lieberman, Frances Tse, Alan N Barkun, Ahmed M Abou-Setta, John K Marshall, N Jewel Samadder, Harminder Singh, Jennifer J Telford, Jill Tinmouth, Anna N Wilkinson, Grigorios I Leontiadis
BACKGROUND & AIMS: A family history (FH) of colorectal cancer (CRC) increases the risk of developing CRC. These consensus recommendations developed by the Canadian Association of Gastroenterology and endorsed by the American Gastroenterological Association, aim to provide guidance on screening these high-risk individuals. METHODS: Multiple parallel systematic review streams, informed by 10 literature searches, assembled evidence on 5 principal questions around the effect of an FH of CRC or adenomas on the risk of CRC, the age to initiate screening, and the optimal tests and testing intervals...
August 16, 2018: Gastroenterology
Amy L Cisyk, Zoann Nugent, Robert H Wightman, Harminder Singh, Kirk J McManus
There are a substantial portion of colorectal cancers (CRCs), termed interval CRCs (I-CRCs), that are diagnosed shortly after a negative colonoscopy (i.e., no detectable polyps or CRC) and before recommended follow-up screening. The underlying cause(s) accounting for I-CRCs remain poorly understood, but may involve aberrant biology that drives genome instability. Genetic defects inducing genome instability are pathogenic events that lead to the development and progression of traditional sporadic (Sp-) CRCs...
September 2018: Neoplasia: An International Journal for Oncology Research
Eugenia N Uche-Anya, Nicole DeCuir, Benjamin Lebwohl
BACKGROUND: Colonoscopy is effective for colorectal cancer (CRC) prevention, yet patients may develop CRC despite adhering to screening/surveillance intervals. There are limited data on predictive factors associated with these postcolonoscopy CRCs (PCCRCs). We aimed to measure PCCRC rates and identify risk factors for PCCRC. METHODS: We performed a case-control study, comparing patients with PCCRCs to spontaneous CRCs diagnosed during a 12.5-year period at an academic medical center...
August 16, 2018: Journal of Clinical Gastroenterology
Muhammad Yasir Khan, Ahmed Dirweesh, Waqas Javed Siddiqui
Background: Colorectal cancer (CRC) is a leading cause of death worldwide. Polyp detection rate (PDR) and adenoma detection rate (ADR) are key focus in endoscopic research for CRC screening and prevention. Use of anti-spasmodic agents during colonoscopy to help identify adenomas and polyps has remained a controversial topic. Hyoscine butyl bromide (HBB) is the most commonly used anti-spasmodic agent in patients undergoing colonoscopy. Some randomized controlled trials (RCTs) have questioned the clinical efficacy and safety of routine use of HBB for polyp and adenoma detection rates...
August 2018: Gastroenterology Research
Lynn F Butterly, Marion R Nadel, Joseph C Anderson, Christina M Robinson, Julia E Weiss, David Lieberman, Jean A Shapiro
BACKGROUND AND AIMS: National guidelines for colonoscopy screening and surveillance assume adequate bowel preparation. We used New Hampshire Colonoscopy Registry (NHCR) data to investigate the influence of bowel preparation quality on endoscopist recommendations for follow-up intervals in average-risk patients following normal screening colonoscopies. METHODS: The analysis included 9170 normal screening colonoscopies performed on average risk individuals aged 50 and above between February 2005 and September 2013...
August 13, 2018: Journal of Clinical Gastroenterology
Nam Hee Kim, Yoon Suk Jung, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND: Obesity and metabolic syndrome are risk factors for colorectal neoplasia (CRN). However, the association between metabolically healthy obese (MHO) or metabolically unhealthy non-obese (MUNO) status and the risk of CRN remains unclear. AIMS: We aimed to elucidate the association between MHO or MUNO status and the risk of CRN. METHODS: A total of 139,023 asymptomatic subjects who underwent a primary screening colonoscopy were categorized into 4 groups according to obesity and metabolic status: metabolically healthy non-obese (MHNO), MHO, MUNO, and metabolically unhealthy obese (MUO)...
November 2018: Digestive Diseases and Sciences
Stefanos Karamaroudis, Aliki Stamou, Stamatia C Vorri, Paraskevas Gkolfakis, Vasilios Papadopoulos, Georgios Tziatzios, Aikaterini Karagouni, Panagiota Katsouli, George D Dimitriadis, Konstantinos Triantafyllou
Background: We monitor colonoscopy service quality biannually, by measuring sedation administration, colonoscopy completion, adenoma detection and early complications rates (CR). We herein present our audit results for the years 2013 and 2015. Methods: In our endoscopy facility, five rotating senior gastroenterologists perform colonoscopies, on a daily basis. We measured the quality indicators in three cohorts: A, intention for total colonoscopy cases; B, cohort A excluding bowel obstruction cases; C, colorectal cancer (CRC) screening cases...
July 2018: Annals of Translational Medicine
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