Lu Ke, Bo Ye, Mingfeng Huang, Tao Chen, Gordon Doig, Chao Li, Yingjie Chen, Hongwei Zhang, Lijuan Zhao, Guobing Chen, Shumin Tu, Long Fu, Honghai Xia, Dongliang Yang, Bin Wu, Baohua Ye, Guoxiu Zhang, Mei Yang, Qiang Li, Xiaomei Chen, Xinting Pan, Wenjian Mao, James Buxbaum, Samir Jaber, Zhihui Tong, Yuxiu Liu, John Windsor, Rinaldo Bellomo, Weiqin Li
OBJECTIVE: To compare the effect of balanced multielectrolyte solutions(BMES) versus normal saline(NS) for intravenous fluid on chloride levels and clinical outcomes.in patients with predicted severe acute pancreatitis (pSAP). SUMMARY BACKGROUND DATA: Isotonic crystalloids are recommended for initial fluid therapy in acute pancreatitis, but whether the use of BMES in preference to NS confers clinical benefits is unknown. METHODS: In this multicenter, stepped-wedge, cluster-randomized trial, we enrolled patients with pSAP (APACHE II score ≥8 and C-reactive protein >150 mg/L) admitted within 72 hours of the advent of symptoms...
May 6, 2024: Annals of Surgery