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https://www.readbyqxmd.com/read/30326483/significance-of-hyperbaric-oxygenation-in-the-treatment-of-fournier-s-gangrene-a-comparative-study
#1
Petra Anheuser, Sandra Mühlstädt, Jennifer Kranz, Laila Schneidewind, Joachim Steffens, Paolo Fornara
INTRODUCTION: Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems to be a key treatment point for Fournier's gangrene. The aim of this study was to investigate the influence of HBO therapy on the outcome and prognosis of Fournier's gangrene. PATIENTS AND METHODS: In the present multicenter, retrospective observational study, we evaluated the data of approximately 62 patients diagnosed with Fournier's gangrene between 2007 and 2017...
October 16, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/30325973/plasma-neutrophil-gelatinase-associated-lipocalin-is-independently-associated-with-left-ventricular-hypertrophy-and-diastolic-dysfunction-in-patients-with-chronic-kidney-disease
#2
Il Young Kim, June Hyun Kim, Min Jeong Kim, Dong Won Lee, Cheol Gu Hwang, Miyeun Han, Harin Rhee, Sang Heon Song, Eun Young Seong, Soo Bong Lee
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are known as predictors of CVD in these patients. Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of acute kidney injury. Recently, elevated NGAL levels have been reported in patients with CVD. This study aimed to evaluate the association between plasma NGAL levels and LVH/LVDD in patients with CKD...
2018: PloS One
https://www.readbyqxmd.com/read/30325779/relationship-of-visceral-and-subcutaneous-adipose-depots-to-markers-of-arterial-injury-and-inflammation-among-individuals-with-hiv
#3
Suman Srinivasa, Kathleen V Fitch, Martin Torriani, Markella V Zanni, Christopher Defilippi, Robert Christenson, Patrick Maehler, Sara E Looby, Janet Lo, Steven K Grinspoon
OBJECTIVE: Persons living with HIV (PLWH) well-treated on antiretroviral therapies remain at risk for ensuing arterial disease. We investigated the relationship between adipose depots and biomarkers of arterial injury and inflammation to gain insight into the link between body composition and CVD risk. DESIGNS/METHODS: 155 HIV-infected and 70 non-HIV-infected individuals were well-phenotyped for body composition. Adipose depots were assessed via single-slice abdominal CT...
October 15, 2018: AIDS
https://www.readbyqxmd.com/read/30325733/leptin-and-adiposity-as-mediators-on-the-association-between-early-puberty-and-several-biomarkers-in-european-adolescents-the-helena-study
#4
Tara Rendo-Urteaga, Augusto César Ferreira de Moraes, Francisco Leonardo Torres-Leal, Yannis Manios, Frederic Gottand, Michael Sjöström, Anthony Kafatos, Kurt Widhalm, Stefaan De Henauw, Dénes Molnár, Ascensión Marcos, Marcela González-Gross, Marika Ferrari, Heráclito B Carvalho, Luis A Moreno
Background Adolescents having early puberty (EP) are more likely to have obesity and increased cardiometabolic and inflammatory markers and atherosclerosis risk. We aimed to assess the indirect and mediated effects of leptin and adiposity on the relation between EP and cardiometabolic and inflammatory markers in European adolescents. Methods A sample of 511 adolescents with EP (12.5-17.5 years) from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study was studied. To assess whether leptin levels and adiposity mediate the relation between EP and several biomarkers, linear regression models for mediation analyses were performed...
October 16, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/30325458/nonalcoholic-fatty-liver-disease-and-30-day-all-cause-mortality-in-adult-patients-with-community-acquired-pneumonia
#5
W B Nseir, J M Mograbi, A E Amara, O H Abu Elheja, M N Mahamid
Aims: Nonalcoholic fatty liver disease (NAFLD) is a common and serious form of chronic liver disease. Risk factors of NAFLD include obesity and type 2 diabetes which are associated with infections. We aimed to determine the association of NAFLD with 30-day all-cause mortality in adult patients with community-acquired pneumonia (CAP). Methods: A retrospective cohort study on hospitalized patients with CAP that was conducted during a period of 4 years. We included patients aged ≥ 18 years with CAP who underwent abdominal ultrasonography...
October 16, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/30325455/the-prevalence-of-serum-magnesium-and-iron-deficiency-anaemia-among-sudanese-women-in-early-pregnancy-a-cross-sectional-study
#6
Reem Eltayeb, Duria A Rayis, Manal E Sharif, Abdel Bagi A Ahmed, Osama Elhardello, Ishag Adam
Background: Anaemia during pregnancy is associated with adverse maternal and child health. Investigations of anaemia and its predictors among pregnant women are needed for preventive measures. Methods: A cross-sectional study was conducted to investigate the prevalence and determinants of anaemia in early pregnancy in Khartoum, Sudan. Clinical characteristics were gathered using a questionnaire. Serum ferritin, magnesium and high-sensitivity C-reactive protein (hs-CRP) were measured using different laboratory methods...
October 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30325378/future-potential-of-osmium-complexes-as-anticancer-drug-candidates-photosensitizers-and-organelle-targeted-probes
#7
Pingyu Zhang, Huaiyi Huang
Recent work has shown that the chemical reactivity of osmium complexes can be finely tuned by the choice of osmium oxidation state, the ligands (including C- and N-bound), and the coordination geometry and stereochemistry, so opening up a wide range of new potential biological and medical applications. Osmium cancer therapeutics can have diverse modes of action and targets, including DNA interactions, redox modulation and protein inhibition. Polypyridyl Os(ii) compounds have potential advantages for luminescent cell imaging and photodynamic therapy due to their favourable photophysical and photochemical properties, such as long-wavelength metal-ligand charge transfer (MLCT) absorptions, high photostability and useful near-infrared (NIR) emission...
October 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30325241/forecast-post-dialysis-blood-pressure-in-hemodialysis-patients-with-intradialytic-hypertension
#8
Lu-Xi Zou, Ling Sun
BACKGROUND: Intradialytic hypertension (IDH) is emerging as an important issue in maintenance hemodialysis (MHD) patients. This study aimed to discuss potential factors related to IDH and build forecasting models for post-dialysis blood pressure (BP) in MHD patients with IDH. METHODS: A total of 266 MHD patients were enrolled, included 133 (50%) patients with IDH and 133 patients without IDH. The BP and pulse were determined and recorded over six consecutive dialysis treatments...
October 16, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/30325124/reliability-of-ultrasonography-and-the-alvarado-scoring-system-in-acute-appendicitis
#9
Ahmet Sami Yazar, Seher Erdoğan, Ceyhan Şahin, Şirin Güven
Yazar AS, Erdoğan S, Şahin C, Güven Ş. Reliability of ultrasonography and the Alvarado scoring system in acute appendicitis. Turk J Pediatr 2018; 60: 173-179. In this study, we aimed to evaluate the diagnostic performance of ultrasonography, the Alvarado score, mean platelet volume and C-reactive protein in the diagnosis of acute appendicitis. Patients admitted to the pediatric emergency department with abdominal pain who were operated on with a preliminary diagnosis of acute appendicitis were evaluated...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30324838/the-efficacy-of-omega-3-fatty-acid-for-gestational-diabetes-a-meta-analysis-of-randomized-controlled-trials
#10
Naer Zhong, Jingnan Wang
INTRODUCTION: The efficacy of omega-3 fatty acid to treat gestational diabetes remains controversial. We conduct a systematic review and meta-analysis to explore the influence of omega-3 fatty acid versus placebo on gestational diabetes. METHODS: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through March 2018 for randomized controlled trials (RCTs) assessing the effect of omega-3 fatty acid versus placebo on gestational diabetes...
October 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/30324775/acute-infection-in-ventilated-patients-in-the-intensive-care-unit-association-between-resting-energy-expenditure-and-c-reactive-protein
#11
David Dahan, Gali Epstein Shochet, Ester Fizitsky, Miriam Almagor, David Shitrit
BACKGROUND: Sepsis is a common cause of hospitalization, particularly in intensive care units (ICUs), and is a major cause of morbidity and mortality. Diagnosis is often difficult due to the absence of characteristic clinical signs (e.g., fever and leukocytosis); therefore, additional markers, in addition to C-reactive protein (CRP) and white blood cell (WBC) count, are needed. OBJECTIVES: To prospectively link resting energy expenditure (REE) with CRP, WBC count, and sequential organ failure assessment (SOFA) scores in ICU patients...
October 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/30324119/the-effect-of-omega-3-fatty-acids-on-serum-apelin-levels-in-cardiovascular-disease-a-randomized-double-blind-placebo-controlled-trial
#12
Akramsadat Mortazavi, Ebrahim Nematipoor, Mahmoud Djalali, Seyed Ali Keshavarz, Simin Samavat, Mahnaz Zarei, Mohammad Hassan Javanbakht
Background: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Omega-3 fatty acids have been shown to have both anti-atherogenic and anti-inflammatory effects through inducing the expression and production of adipokines. Adipokines such as apelin, have been observed to play a protective role in the incidence and progression of CVD. The aim of this study was to assess the influence of omega-3 fatty acids supplementation on the serum apelin levels in patients with cardiovascular disease...
October 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/30323922/c-reactive-protein-point-of-care-testing-in-the-management-of-acute-respiratory-infections-in-the-vietnamese-primary-healthcare-setting-a-cost-benefit-analysis
#13
Yoel Lubell, Nga T T Do, Kinh V Nguyen, Ngan T D Ta, Ninh T H Tran, Hung M Than, Long B Hoang, Poojan Shrestha, Rogier H van Doorn, Behzad Nadjm, Heiman F L Wertheim
Aim: We assess the cost-benefit implications of C-reactive protein (CRP) testing in reducing antibiotic prescription for acute respiratory infection in Viet Nam by comparing the incremental costs of CRP testing with the economic costs of antimicrobial resistance averted due to lower antibiotic prescribing. Findings: Patients in the CRP group and the controls incurred similar costs in managing their illness, excluding the costs of the quantitative CRP tests, provided free of charge in the trial context...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/30323607/index-c-reactive-protein-predicts-increased-severity-in-acute-sigmoid-diverticulitis
#14
Aristotelis Kechagias, Anastasios Sofianidis, Georgios Zografos, Emmanouel Leandros, Nicholas Alexakis, Christos Dervenis
Purpose: Conservative management is successful in unperforated (Hinchey Ia) acute diverticulitis (AD) and also generally in local perforation or small abscesses (Hinchey Ib). A higher degree of radiological severity (Hinchey >Ib), ie, a larger abscess (>3-4 cm) or peritonitis, commonly requires percutaneous drainage or surgery. Retrospective studies show that high levels of C-reactive protein (CRP) distinguish Hinchey Ia from all cases of minor and major perforations (Hinchey >Ia)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/30323348/catch-up-growth-metabolic-and-cardiovascular-risk-in-post-institutionalized-romanian-adolescents
#15
Alva Tang, Natalie Slopen, Charles A Nelson, Charles H Zeanah, Michael K Georgieff, Nathan A Fox
BACKGROUND: Reduced prenatal growth followed by rapid postnatal weight gain are risk factors for developing metabolic and cardiovascular disease. Children reared in institutions experience a similar pattern of growth restriction followed by catch-up growth after removal. We explored whether patterns of catch-up growth affect metabolic and cardiovascular outcomes in previously institutionalized adolescents. METHOD: A longitudinal study of institutionalized infants randomized to care as usual (n = 68) or foster care intervention (n = 68), and never institutionalized controls (n = 127)...
October 1, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30322810/decreased-plasma-neuregulin-4-levels-are-associated-with-peripheral-neuropathy-in-chinese-patients-with-newly-diagnosed-type-2-diabetes-a-cross-sectional-study
#16
Pijun Yan, Yong Xu, Zhihong Zhang, Chenlin Gao, Jianhua Zhu, Hua Li, Qin Wan
Neuregulin-4 (Nrg4) is a novel adipokine associated with obesity, hyperglycemia, insulin resistance, dislipidemia, inflammation, and oxidative stress in mice and humans. However, no report has demonstrated the relationship of circulating Nrg4 with diabetic peripheral neuropathy (DPN). The objective of our study was to investigate the relationship between circulating Nrg4 and DPN in a cross-sectional study. Circulating Nrg4 levels were determined with an enzyme-linked immunosorbent assays kit in 132 newly diagnosed type 2 diabetes mellitus (nT2DM) patients and 41 normal controls (NC group)...
October 12, 2018: Cytokine
https://www.readbyqxmd.com/read/30322787/prevalence-of-pica-in-patients-on-dialysis-and-its-association-with-nutritional-status
#17
Claudia N Orozco-González, Laura Cortés-Sanabria, Alfonso M Cueto-Manzano, Beatriz Corona-Figueroa, Héctor R Martínez-Ramírez, Jorge López-Leal, Fabiola Martín-Del-Campo, Enrique Rojas-Campos, Benjamín Gómez-Navarro
OBJECTIVE: Pica could be strongly implicated in nutritional status of patients on dialysis; however, very scarce data are currently available. The objective of this study was to evaluate the prevalence of pica and its association with nutritional status in dialysis patients. DESIGN AND METHODS: This is a cross-sectional study in a tertiary care teaching hospital. Four-hundred patients on dialysis, without previous pica diagnosis or transplant, pregnancy, mental illness, or infection, were included in the study...
October 12, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/30322786/truncal-adiposity-influences-high-density-lipoprotein-cholesterol-levels-and-cardiovascular-events-in-hemodialysis-patients
#18
Go Takahashi, Hirokazu Honda, Keiko Takahashi, Misa Ikeda, Nozomu Hosaka, Hiroaki Ogata, Fumihiko Koiwa, Kanji Shishido, Takanori Shibata
OBJECTIVE: Adiposity influences lipid metabolism and atherosclerotic cardiovascular disease (CVD) in the general population. The aim of the present study was to assess the association between fat mass (FM) and lipid metabolism and CVD events among patients on hemodialysis (HD). METHODS: This prospective observational study examined 240 patients on prevalent HD. Blood samples were obtained before dialysis at baseline to measure lipids, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, and adiponectin...
October 12, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/30322438/a-revised-treatment-approach-for-hospitalized-patients-with-eosinophilic-and-neutrophilic-exacerbations-of-chronic-obstructive-pulmonary-disease
#19
Emine Aksoy, Sinem Güngör, Meltem Çoban Ağca, İpek Özmen, Dildar Duman, Nagihan Durmuş Koçak, Ülkü Aka Aktürk, Eylem Tunçay, Cüneyt Saltürk, Murat Yalçınsoy, Birsen Ocaklı, Zuhal Karakurt
OBJECTIVES: The choice of treatment according to the inflammation type in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has been of recent interest. This study investigated the role of novel biomarkers, hospital outcomes, and readmission rates in the first month in patients with eosinophilic or neutrophilic AECOPD. MATERIALS AND METHODS: We conducted a retrospective observational cohort study in a Chest Teaching Hospital with hospitalized AECOPD patients...
September 13, 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/30321669/mendelian-randomization-in-the-bone-field
#20
Susanna C Larsson, Karl Michaëlsson, Stephen Burgess
Identification of causative risk factors amenable for modification is essential for the prevention and treatment of osteoporosis. Observational studies have identified associations between several potentially modifiable risk factors and osteoporosis. However, observational studies are susceptible to confounding, reverse causation bias, and measurement error, all of which limit their ability to provide causal estimates of the effect of exposures on outcomes, thereby reducing their ability to inform prevention and treatment strategies against bone loss and fractures...
October 12, 2018: Bone
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