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https://www.readbyqxmd.com/read/30110707/prepubertal-children-exposed-to-maternal-gestational-diabetes-have-latent-low-grade-inflammation
#1
Leena Antikainen, Jarmo Jääskeläinen, Henrikki Nordman, Raimo Voutilainen, Hanna Huopio
BACKGROUND: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children's height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. METHODS: A cohort of 135 prepubertal Caucasian children (age range 4.4-9.7 years) was studied in a controlled cross-sectional study...
August 15, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/30110693/effect-of-celecoxib-on-surgical-site-inflammation-after-total-knee-arthroplasty-a-randomized-controlled-study
#2
Xun Xu, Weilin Sang, Yu Liu, Libo Zhu, Haiming Lu, Jinzhong Ma
OBJECTIVE: To evaluate the anti-inflammatory effectiveness of celecoxib and its effect on the rehabilitation of joint function after total knee arthroplasty. METHODS: 72 who patients presented between 2016 and 2017 were divided into two groups. The experimental group was given 200 mg celecoxib twice daily with tramadol hydrochloride 50 mg twice daily (as required); the control group was given tramadol hydrochloride 50 mg twice daily for 6 weeks from the first day after total knew arthroplasty...
August 15, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/30110274/correlation-between-apolipoprotein-m-and-inflammatory-factors-in-obese-patients
#3
Tie Li, Liu Yang, Shuiping Zhao, Saidan Zhang
BACKGROUND The aim of this study was to observe apolipoprotein M (ApoM) level in obese patients and to explore its correlation with inflammatory factors. MATERIAL AND METHODS A total number of 96 participants were recruited and divided into 2 groups: the control group (or healthy group) whose participants had normal body weight (n=58), and the obese group with all its participants diagnosed with obesity (n=38). Data on blood pressure, body weight, height, body mass index, diastolic function of brachial artery endothelium, fasting venous blood glucose, blood lipids, plasmatic ApoM, interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), fasting insulin, and adiponectin levels were collected for both groups...
August 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/30110118/study-of-pulmonary-function-tests-in-type-2-diabetes-mellitus-and-their-correlation-with-glycemic-control-and-systemic-inflammation
#4
Rupali Malik, Ilavarasi Vanidassane, Neelima Jain
Background - Reduced lung function in diabetes has been described for long but its clinical importance is not yet clear. Also, limited literature is available regarding its association with sugar control, and its correlation with inflammatory markers. Thus, we aimed to study the pulmonary function test abnormalities and systemic inflammation in type 2 diabetes mellitus. Methods 100 patients of type 2 diabetes were divided into two groups depending on control of diabetes (group A-HbA1C≤7% and group B-HbA1C >7%)...
August 15, 2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/30109938/meloxicam-improves-cognitive-impairment-of-diabetic-rats-through-cox2-pge2-eps-camp-ppka-pathway
#5
Huan Li, Ying Luo, Ying Xu, Lu Yang, Congli Hu, Qi Chen, Yang Yang, Jie Ma, Jiahua Zhang, Hui Xia, Yuke Li, Junqing Yang
Diabetics often face greater risk of cognitive impairment than non-diabetics. However, how to prevent this disease is still unconfirmed. In this study, we investigated the potential protection and mechanism of meloxicam on cognitive impairment in diabetic rats. Diabetic rat model was established with high-fat diet and a small dose of streptozotocin (40 mg/kg). The changes of spatial learning and memory, histopathology and the protein expressions of amyloid protein precursor (APP) and β-amyloid (Aβ) indicated that diabetic rats had neuronal injury and cognitive impairment...
August 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30109928/reactions-of-auranofin-and-its-pseudohalide-derivatives-with-serum-albumin-investigated-through-esi-q-tof-ms
#6
Alessandro Pratesi, Damiano Cirri, Lorenzo Ciofi, Luigi Messori
The reactions of auranofin and three pseudohalide derivatives with bovine serum albumin were explored by ESI-Q-TOF mass spectrometry; a detailed molecular description of the resulting adducts is achieved revealing even subtle differences in reactivity within this series of gold(I) complexes. Our study shows that this kind of investigative approach, formerly applied to the interactions of metal-based drugs with small model proteins of MW 10-15 kDa, e.g., cytochrome c and lysozyme, may now be extended with success to far larger proteins such as serum albumin (MW 66 kDa)...
August 15, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/30109863/the-utility-of-high-sensitivity-c-reactive-protein-levels-in-patients-with-moderate-coronary-lesions-and-gray-zone-fractional-flow-reserve
#7
Lin Li, Qi Wei Liu, Zhe Li, Li Wang, Jian Hong Wang, Lei Song, Bin Li
OBJECTIVE: It remains controversial whether patients with fractional flow reserve (FFR) values of 0.75-0.80 (gray-zone) should be treated with percutaneous coronary intervention (PCI). This study aimed to evaluate the prediction of high-sensitivity C-reactive protein (hs-CRP) levels to guide treatment selection in gray-zone patients. METHODS: This prospective interventional trial was conducted between January 2015 and March 2016. A total of 785 patients with stable angina and single-vessel stenosis with moderate coronary lesions were admitted to hospital in this period...
August 15, 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/30109794/prompt-clinical-response-to-secukinumab-in-patients-with-axial-spondyloarthritis-real-life-observational-data-from-three-italian-referral-centers
#8
Stefano Gentileschi, Antonio Vitale, Donato Rigante, Giuseppe Lopalco, Giacomo Emmi, Ida Orlando, Gerardo Di Scala, Jurgen Sota, Claudia Fabiani, Bruno Frediani, Mauro Galeazzi, Giovanni Lapadula, Florenzo Iannone, Luca Cantarini
BACKGROUND: Clinical research is needed to identify patients with axial spondyloarthritis (axSpA) who are more likely to be responsive to interleukin (IL)-17 inhibition. OBJECTIVES: To evaluate short-term efficacy of secukinumab in the management of axSpA. METHODS: Twenty-one patients (7 males, 14 females) with axSpA were consecutively treated with secukinumab. Laboratory and clinical assessments were based on erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Ankylosing Spondylitis Disease Activity Score (ASDAS)-CRP, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)...
July 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/30109509/inflammatory-dietary-pattern-and-risk-of-developing-rheumatoid-arthritis-in-women
#9
Jeffrey A Sparks, Medha Barbhaiya, Sara K Tedeschi, Cianna L Leatherwood, Fred K Tabung, Cameron B Speyer, Susan Malspeis, Karen H Costenbader, Elizabeth W Karlson, Bing Lu
Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses' Health Study (NHS, 1984-2014) and 93,572 women in the NHSII (1991-2013); incident RA was confirmed by medical records. Food frequency questionnaires (FFQ) were completed at baseline and approximately every 4 years. Inflammatory dietary pattern was assessed from FFQ data using the Empirical Dietary Inflammatory Pattern (EDIP), including 18 anti-/pro-inflammatory food/beverage groups weighted by correlations with plasma inflammatory biomarkers (interleukin-6, C-reactive protein, and tumor necrosis factor-α receptor 2)...
August 14, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/30108903/a-%C3%AE-carboline-derivative-based-nickel-ii-complex-as-a-potential-antitumor-agent-synthesis-characterization-and-cytotoxicity
#10
Jing-Mei Yang, Yan-Hong Zhu, Sheng Chen, Xing Lu, Yi-Ming Wu, Feng-E Ma, Liang-Ping Li, Yang Yang, Zhen-Hao Shi, Kun-Yuan Huang, Xue Hong, Ping Jiang, Yan Peng
A novel nickel(ii) complex of 6-methoxy-1-pyridine-β-carboline ( 4a ) was synthesized and characterized. The cytotoxicities of the complex towards six cancer cell lines, including MGC-803, Hep G2, T24, OS-RC-2, NCI-H460, and SK-OV-3, and human normal liver cell line HL-7702 were investigated. The IC50 values for MGC-803, Hep G2, T24, OS-RC-2, NCI-H460 and SK-OV-3 were generally in the micromolar range (3.77-15.10 μM), lower than those of ligand 4 and cisplatin. Furthermore, 4a (6 μM) significantly induced cell cycle arrest at the S phase, and caused the down-regulation of p-AKT, cyclin E, cyclin A and CDK2 and the up-regulation of p27...
January 1, 2018: MedChemComm
https://www.readbyqxmd.com/read/30108640/effect-of-cardiac-rehabilitation-on-inflammation-a-systematic-review-and-meta-analysis-of-controlled-clinical-trials
#11
Masoumeh Sadeghi, Hossein Khosravi-Broujeni, Amin Salehi-Abarghouei, Ramin Heidari, Gholamreza Masoumi, Hamidreza Roohafza
BACKGROUND: This systematic review and meta-analysis aimed to assess the effect of cardiac rehabilitation (CR) on serum C-reactive protein (CRP) as an indicator of the inflammatory state and predictor of recurrent cardiovascular events. METHODS: PubMed, SCOPUS, Cochrane library, and Google Scholar databases were searched up to January 2014 for original articles which investigated the effect of CR on CRP among adult patients with previous cardiovascular events. The random effects model was used to assess the overall effect of CR on the variation in serum CRP levels...
March 2018: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/30108172/exposure-to-arsenite-in-cd-1-mice-during-juvenile-and-adult-stages-effects-on-intestinal-microbiota-and-gut-associated-immune-status
#12
Kuppan Gokulan, Matthew G Arnold, Jake Jensen, Michelle Vanlandingham, Nathan C Twaddle, Daniel R Doerge, Carl E Cerniglia, Sangeeta Khare
Intestinal microbiota composition and gut-associated immune response can contribute to the toxicity of arsenic. We investigated the potential toxicity of short-term arsenic exposure on gut microbiome composition, intestinal immune status, microbial arsenic resistance gene, and arsenic metabolic profiles in adult and developmental stages of CD-1 mice. The potential toxicity of arsenite [As(III)] was determined for two life stages: (i) adult animals at 24 or 48 h after single gavage (0.05 mg/kg body weight [b...
August 14, 2018: MBio
https://www.readbyqxmd.com/read/30107791/c-reactive-protein-and-procalcitonin-to-discriminate-between-tuberculosis-pneumocystis-jirovecii-pneumonia-and-bacterial-pneumonia-in-hiv-infected-inpatients-meeting-who-criteria-for-seriously-ill-a-prospective-cohort-study
#13
Fiona Mendelson, Rulan Griesel, Nicki Tiffin, Molebogeng Rangaka, Andrew Boulle, Marc Mendelson, Gary Maartens
BACKGROUND: Tuberculosis, bacterial community-acquired pneumonia (CAP), and Pneumocystis jirovecii pneumonia (PJP) are the three commonest causes of hospitalisation in HIV-infected adults. Prompt diagnosis and treatment initiation are important to reduce morbidity and mortality, but are hampered by limited diagnostic resources in resource poor settings. C-reactive protein (CRP) and procalcitonin have shown diagnostic utility for respiratory tract infections, however few studies have focussed on their ability to distinguish between tuberculosis, CAP, and PJP in HIV-infected inpatients...
August 14, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/30106856/adolescent-obesity-is-an-independent-risk-factor-for-sensorineural-hearing-loss-results-from-the-national-health-and-nutrition-examination-survey-2005-to-2010
#14
Gavriel D Kohlberg, Ryan T Demmer, Anil K Lalwani
OBJECTIVE: We investigated the hypothesis that childhood obesity is a risk factor for sensorineural hearing loss (SNHL) independent of other metabolic risk factors. STUDY DESIGN: A complex, multistage, stratified geographic area design for collecting representative data from noninstitutionalized US population. METHODS: A total of 5,638 adolescents between age 12 and 19 from the NHANES database (2005-2010) were studied. Subjects with body mass index >= 95th percentile were classified as obese...
August 13, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30106520/the-importance-of-hypoalbuminemia-in-peritoneal-dialysis-patients-impact-of-gender
#15
Dorota Sikorska, Anna Olewicz-Gawlik, Ewa Baum, Krzysztof Pawlaczyk, Andrzej Oko
BACKGROUND: High mortality in peritoneal dialysis (PD) patients is associated with the presence of nontraditional cardiovascular risk factors, such as malnutrition. However, hypoalbuminemia in patients undergoing PD may have gender-dependent consequences. OBJECTIVES: The aim of the study was to evaluate the relationship between hypoalbuminemia, overhydration (OH), inflammation, and cardiovascular risk, depending on gender. MATERIAL AND METHODS: The group studied consisted of 54 PD patients: 26 male (mean age: 59 ±19 years) and 28 female (mean age: 52 ±15 years) patients...
August 14, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/30106415/coronary-artery-bypass-surgery-in-syrian-refugees-outcomes-in-a-turkish-tertiary-center
#16
Mazlum Sahin, Semi Öztürk, Tugba I Mert, Gündüz Durmuş, Mehmet Mustafa Can
OBJECTIVE: To assess  outcomes of Syrian refugees undergoing coronary artery bypass surgery in a tertiary hospital in Turkey. METHODS:  We sought for in-hospital mortality and one year all-cause mortality as the main outcomes. We reviewed records of 67 Syrian and 427 Turkish patients undergoing isolated coronary bypass surgery between 2015 January and 2017 January retrospectively.  Results: History of coronary, peripheral and carotid artery diseases and obesity were more frequent in Syrian patients...
July 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/30106111/sulforaphane-protects-rabbit-corneas-against-oxidative-stress-injury-in-keratoconus-through-activation-of-the-nrf-2-ho-1-antioxidant-pathway
#17
Ruixing Liu, Xiaoming Yan
The aim of the present study was to examine whether activation of the nuclear factor E2‑related factor 2 (Nrf‑2)/heme oxygenase‑1 (HO‑1) antioxidant pathway in the cornea was involved in the protective effect of sulforaphane (SF) following keratoconus (KC) injury. Following epithelial debridement, collagenase type II was applied in KC groups at room temperature for 30 min. Following this, rabbits were administered with a subconjunctival (s.c.) injection of SF or placebo (maize oil) daily for a total of 2 weeks...
August 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/30106096/theaflavins-attenuate-ethanol%C3%A2-induced-oxidative-stress-and-cell-apoptosis-in-gastric-mucosa-epithelial-cells-via-downregulation-of-the-mitogen%C3%A2-activated-protein-kinase-pathway
#18
Zheng Wang, Hesheng Luo, Hong Xia
Ethanol‑induced diseases of the gastric mucosa are the most common and refractory diseases of gastrointestinal system in clinic, and are mediated by oxidative stress and apoptosis pathways. Theaflavins (TFs) are considered to be antioxidants. The present study aimed to determine the molecular mechanism underlying the ability of TFs to attenuate ethanol‑induced oxidative stress and apoptosis in GES‑1 gastric mucosa epithelial cells. A Cell Counting Kit‑8 (CCK‑8) assay was performed to investigate the cell viability of GES‑1 cells following administration of ethanol (0...
August 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30105924/tanshinone-iia-activates-nuclear-factor-erythroid-2-related-factor-2-to-restrain-pulmonary-fibrosis-via-regulation-of-redox-homeostasis-and-glutaminolysis
#19
Lin An, Li-Ying Peng, Ning-Yuan Sun, Yi-Lin Yang, Xiao-Wei Zhang, Bin Li, Bao-Lin Liu, Ping Li, Jun Chen
AIMS: Pulmonary fibrosis (PF) is characterized by myofibroblast activation through oxidative stress. However, the precise regulation of myofibroblast transdifferentiation remain largely uncharacterized. RESULTS: In this study, we found that tanshinone IIA (Tan-IIA), an active component in the root of Salvia miltiorrhiza Bunge, can suppress reactive oxygen species (ROS)-mediated activation of myofibroblast and reduce extracellular matrix deposition in bleomycin (BLM)-challenged mice through regulation of nuclear factor-erythroid 2-related factor 2 (Nrf2)...
August 14, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/30105859/sirtuin6-inhibits-c-triggered-inflammation-through-tlr4-abrogation-regulated-by-ros-and-trpv1-cgrp
#20
Ruohua Zhang, Hongmin Li, Qin Guo, Lulu Zhang, Jie Zhu, Jin Ji
Propionibacterium acnes induces inflammatory and plays a vital role in the formation of comedones through activation of inflammatory cells, keratinocytes, and sebocytes. Sirtuin6 (SIRT6), along with ADP-ribosyltransferase and deacetylase, has been proposed to mediate various biological functions, including inflammation. Nevertheless, no strong experimental evidence has been provided to support the effect of SIRT6 in treatment of inflammatory situation. Therefore, this study addressed the inhibitory effect of SIRT6 against P...
August 13, 2018: Journal of Cellular Biochemistry
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