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https://www.readbyqxmd.com/read/30541130/a-coronary-artery-disease-associated-trnathr-mutation-altered-mitochondrial-function-apoptosis-and-angiogenesis
#1
Zidong Jia, Ye Zhang, Qiang Li, Zhenzhen Ye, Yuqi Liu, Changzhu Fu, Xiaohui Cang, Meng Wang, Min-Xin Guan
The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects of tRNAThr 15927G>A mutation that contributed to pathogenesis of coronary artery disease. The m.15927G>A mutation abolished the highly conserved base-pairing (28C-42G) of anticodon stem of tRNAThr. Using molecular dynamics simulations, we showed that the m.15927G>A mutation caused unstable tRNAThr structure, supported by decreased melting temperature and slower electrophoretic mobility of mutated tRNA...
December 12, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/30541093/a-12-wk-whole-grain-wheat-intervention-protects-against-hepatic-fat-the-graandioos-study-a-randomized-trial-in-overweight-subjects
#2
Sophie Schutte, Diederik Esser, Femke P M Hoevenaars, Guido J E J Hooiveld, Marion G Priebe, Roel J Vonk, Suzan Wopereis, Lydia A Afman
Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions. Objective: The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters...
December 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/30541021/management-of-paediatric-patients-with-medically-refractory-crohn-s-disease-using-ustekinumab-a-multi-centred-cohort-study
#3
Mallory Chavannes, Christine Martinez-Vinson, Lara Hart, Nicole Kaniki, Che-Yung Chao, Sally Lawrence, Kevan Jacobson, Jean-Pierre Hugot, Jérome Viala, Colette Deslandres, Prevost Jantchou, Ernest G Seidman
Background: Ustekinumab (UST) is effective in the treatment of adults with moderate to severe Crohn's disease (CD). There is a paucity of data on its use in children. Aim: To evaluate the response to UST in children with moderate to severe CD. Methods: This multi-centre retrospective cohort study identified children under 18 years old with CD who received open-labelled subcutaneous UST. The primary outcome was changes in mean abbreviated PCDAI (aPCDAI) between baseline and 3 and 12 months, and rate of clinical remission at 3 and 12 months...
December 12, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/30540842/dietary-total-antioxidant-capacity-tac-among-candidates-for-coronary-artery-bypass-grafting-cabg-surgery-emphasis-to-possible-beneficial-role-of-tac-on-serum-vitamin-d
#4
Mahdieh Abbasalizad Farhangi, Mahdi Najafi
AIMS: Recently, the clinical importance of total antioxidant capacity (TAC) and its protective role against several chronic diseases like cardiovascular disease, osteoporosis and several types of cancers has been reported. However, its association with cardio-metabolic risk factors among patients candidate for coronary artery bypass graft surgery (CABG) has not been evaluated yet. CABG is associated with increased oxidative stress and free radicals; so, the current study was aimed to evaluate the potential association of TAC with cardiovascular risk factors among patients candidate for CABG...
2018: PloS One
https://www.readbyqxmd.com/read/30540752/systemic-involvement-in-acs-using-cmr-imaging-to-compare-the-aortic-wall-in-patients-with-and-without-acute-coronary-syndrome
#5
Elizabeth Chandy, Alexander Ivanov, Devindra S Dabiesingh, Alexandra Grossman, Prasanthi Sunkesula, Lakshmi Velagapudi, Virna L Sales, Edward J Colombo, Igor Klem, Terrence J Sacchi, John F Heitner
BACKGROUND/OBJECTIVES: Previous studies have demonstrated that in acute coronary syndrome (ACS), plaque destabilization and vessel inflammation, represented by vessel edema, often occur simultaneously in multiple coronaries, as well as extend to the cerebrovascular system. Our aim was to determine whether the inflammatory vascular processes occurring within the coronaries during ACS extend simultaneously to the descending aorta. METHODS: We prospectively enrolled 111 patients (56 ACS patients and 55 non-ACS patients with known coronary artery disease) to undergo cardiac magnetic resonance of the thoracic aortic wall at presentation and at three-month follow-up...
2018: PloS One
https://www.readbyqxmd.com/read/30540681/diagnostic-and-prognostic-impact-of-neutrophil-to-lymphocyte-ratio-for-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-with-high-grade-dysplasia-and-associated-invasive-carcinoma
#6
Tatsuo Hata, Masamichi Mizuma, Fuyuhiko Motoi, Masaharu Ishida, Takanori Morikawa, Tatsuyuki Takadate, Kei Nakagawa, Hiroki Hayashi, Atsushi Kanno, Atsushi Masamune, Takashi Kamei, Toru Furukawa, Takeshi Naitoh, Michiaki Unno
OBJECTIVES: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma. METHODS: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. RESULTS: The median (interquartile range) preoperative NLR was higher in IPMN with HGD/invasive carcinoma (2...
January 2019: Pancreas
https://www.readbyqxmd.com/read/30540251/reactive-oxygen-species-regulate-activity-dependent-neuronal-plasticity-in-drosophila
#7
Matthew C W Oswald, Paul S Brooks, Maarten F Zwart, Amrita Mukherjee, Ryan J H West, Carlo N G Giachello, Khomgrit Morarach, Richard A Baines, Sean T Sweeney, Matthias Landgraf
Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior...
December 12, 2018: ELife
https://www.readbyqxmd.com/read/30540086/correlation-between-nonalcoholic-fatty-liver-disease-features-and-levels-of-adipokines-and-inflammatory-cytokines-among-morbidly-obese-individuals
#8
Letícia Baltieri, Elinton Adami Chaim, Felipe David Mendonça Chaim, Murillo Pimentel Utrini, Martinho Antonio Gestic, Everton Cazzo
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the commonest hepatopathy worldwide. OBJECTIVE: To investigate the correlations between NAFLD histopathological features and the levels of adipokines (adiponectin, leptin, and resistin) and circulating inflammatory markers (interleukin-6 [IL-6], interleukin-8 [IL-8], tumor necrosis factor alpha [TNF-α], and C-reactive protein [CRP]). METHODS: This is an exploratory cross-sectional study, which enrolled 19 women with obesity who underwent bariatric surgery...
July 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/30539977/impact-of-bariatric-surgery-on-the-inflammatory-state-based-on-cpr-value
#9
Renato Migliore, João Kleber Almeida Gentile, Fabiana Tornincasa Franca, Guilherme Tommasi Kappaz, Pedro Marcos Santinho Bueno-DE-Souza, José Cesar Assef
BACKGROUND: PCR (C-reactive protein), produced in the liver after stimuli of inflammatory mediators, is determined as a marker of inflammatory activity (adipocytokines) and is present within adipocyte cells; besides being an inflammatory product, many studies have shown to be a predictor of complications. AIM: To determine if the inflammatory state of the obese patient decreases after bariatric surgery, based on pre and post-operative PCR. METHODS: A prospective, observational study in patients undergoing Roux-en-Y gastric by-pass surgery followed up for three months after surgery, with serum preoperative CRP in 30, 60 and 90 days after surgery...
December 6, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/30539973/effects-of-renal-dysfunction-on-healing-of-colonic-anastomosis-experimental-study-in-wistar-rats
#10
Carlos Eduardo da Silva, João Carlos Domingues Repka, Carlos José Franco de Souza, Jorge Eduardo Fouto Matias
BACKGROUND: Chronic kidney disease affects more than 500 million people worldwide. In this context, the uremic toxins present are related to worsening in tissue healing. AIM: Evaluate on healing of colonic anastomosis in uremic rats, serum and anatomopathological indicators, which may be related to the change tissue repair process. METHODS: Twenty Wistar rats, were randomly separated into two groups. In the sham group they were submitted to 5/6 nephrectomy simulation in left kidney, simulation right nephrectomy, median laparotomy, colotomy and colorraphy...
December 6, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/30539580/determination-of-crp-autoantibodies-by-spr-immunoassay
#11
Qiu-Yu Li, Hai-Yun Li
Biosensors based on the principle of surface plasmon resonance (SPR) are surface-sensitive optical devices used for monitoring biomolecular interactions at the sensor surface in real time without any labeling. It is used in a wide variety of areas including proteomics, clinical diagnosis, environmental monitoring, drug discovery, and food analysis. C-reactive protein (CRP) is a marker of inflammation, which undergoes conformation changes in local lesions, leading to the formation of mCRP. Autoantibodies against mCRP are frequently detected in systemic lupus erythematosus (SLE) and associated with disease activity and prognosis...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30539577/analysis-of-anti-c1q-autoantibodies-by-western-blot
#12
Anci Verlemyr, Lennart Truedsson, Lillemor Skattum
Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of complement, C1q. These different binding specificities can be detected by Western blot analysis of the autoantibodies under reducing conditions...
2019: Methods in Molecular Biology
https://www.readbyqxmd.com/read/30539404/the-effects-of-repeated-applications-of-antimicrobial-photodynamic-therapy-in-the-treatment-of-residual-periodontal-pockets-a-systematic-review
#13
T P M Franco, A P P Dos Santos, Antonio Canabarro
The aim of this study was to assess the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) on the non-surgical periodontal treatment of residual pockets. This work was performed and reported according to the Cochrane and PRISMA recommendations, respectively, and registered at the PROSPERO registry (number CRD42017058403). An extensive search of the biomedical literature was conducted on four databases from January 1960 to August 2018, followed by hand searching. Analysis of the quality of the selected studies was based on the risk of bias...
December 11, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/30539188/thermally-imprinted-microcone-structure-assisted-lateral-flow-immunoassay-platforms-for-detecting-disease-marker-proteins
#14
Shuhei Aoyama, Yuto Akiyama, Kenji Monden, Masumi Yamada, Minoru Seki
Although various types of on-site immunoassay platforms have been developed, facile and reliable sample-to-answer immunoassay systems are still under development. In this study, we proposed a lateral-flow immunoassay system utilizing a polymer sheet with microcone array structures fabricated by thermal imprinting. By adding a surfactant to the running/washing buffer, we were able to dispense with complicated chemical modification protocols, which are usually necessary to enhance antibody adsorption. We investigated three types of polymeric materials and confirmed that polycarbonate is most suitable as an imprinted polymer substrate...
December 12, 2018: Analyst
https://www.readbyqxmd.com/read/30538977/association-of-early-life-exposure-to-phthalates-with-obesity-and-cardiometabolic-traits-in-childhood-sex-specific-associations
#15
Marina Vafeiadi, Antonis Myridakis, Theano Roumeliotaki, Katerina Margetaki, Georgia Chalkiadaki, Eirini Dermitzaki, Maria Venihaki, Katerina Sarri, Maria Vassilaki, Vasiliki Leventakou, Euripides G Stephanou, Manolis Kogevinas, Leda Chatzi
Few studies have investigated longitudinal associations between early life phthalate exposure and subsequent obesity and cardiovascular risks in children with inconsistent results. We aimed to evaluate the associations between phthalate exposure during gestation and childhood with offspring obesity and cardiometabolic risk factors in 500 mother-child pairs from the Rhea pregnancy cohort in Crete, Greece. Seven phthalate metabolites [monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethylhexyl) phthalate (MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP)] were quantified in spot urine samples collected from mothers (1st trimester) and their children at 4 years of age...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/30538782/circulating-semaphorin-4d-as-a-marker-for-predicting-radiographic-progression-in-patients-with-rheumatoid-arthritis
#16
You-Jung Ha, Dong Woo Han, Ji Hyoun Kim, Sang Wan Chung, Eun Ha Kang, Yeong Wook Song, Yun Jong Lee
Semaphorin 3A (Sema3A) and semaphorin 4D (Sema4D) are molecules which regulate immune responses as well as bone remodeling process. The aim of this study was to evaluate the serum levels of Sema3A and Sema4D and to investigate their clinical significance in rheumatoid arthritis (RA). The serum levels of Sema3A and Sema4D were measured in 130 patients with RA and 65 sex- and age-matched healthy individuals. Circulating levels of biomarkers of RA-related inflammation and bone turnover such as tumor necrosis factor- (TNF-) α , interleukin- (IL-) 6, IL-22, IL-34, osteopontin, Dkk-1, and sclerostin were also measured...
2018: Disease Markers
https://www.readbyqxmd.com/read/30538765/evaluating-the-efficacy-and-adverse-effects-of-clearing-heat-and-removing-dampness-method-of-traditional-chinese-medicine-by-comparison-with-western-medicine-in-patients-with-gout
#17
REVIEW
Nan Xiao, Hao Chen, Shi-Yong He, Chong-Xiang Xue, Hua Sui, Jing Chen, Jia-Lin Qu, Li-Na Liang, Lin Zhang
Objective. In China, the method of clearing heat and removing dampness medicine of Chinese traditional medicine has been widely used on gout. However, the clinical effects are various and not summarized systematically. Methods. In this study, a large number of randomized controlled clinical trials were reviewed and analyzed and the clinical efficacy and adverse reactions of traditional Chinese medicine with clearing heat and removing dampness effects for the treatment of gout were systematically evaluated. A comprehensive search of databases including pubMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, Wanfang Data, and SinoMed was performed...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30538644/inflammatory-measures-in-depressed-patients-with-and-without-a-history-of-adverse-childhood-experiences
#18
Karin de Punder, Sonja Entringer, Christine Heim, Christian E Deuter, Christian Otte, Katja Wingenfeld, Linn K Kuehl
Background: Major depressive disorder (MDD) is a complex psychiatric condition with different subtypes and etiologies. Exposure to adverse childhood experiences (ACE) is an important risk factor for the development of MDD later in life. Evidence suggests that pro-inflammatory processes may convey this risk as both MDD and ACE have been related to increased levels of inflammation. In the present study, we aimed to disentangle the effects of MDD and ACE on inflammation levels. Methods: Markers of inflammation (plasma interleukin(IL)-6 and high sensitive C-reactive protein (hsCRP) concentrations, white blood cell (WBC) count and a composite inflammation score (CIS) combining all three) were assessed in 23 MDD patients with ACE, 23 MDD patients without ACE, 21 healthy participants with ACE, and 21 healthy participants without ACE (mean age: 35 ± 11 (SD) years)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30538461/co-exposure-subacute-toxicity-of-silica-nanoparticles-and-lead-acetate-on-cardiovascular-system
#19
Lin Feng, Xiaozhe Yang, Yanfeng Shi, Shuang Liang, Tong Zhao, Junchao Duan, Zhiwei Sun
Background: The harmful effects following the release of nanomaterials into environment are of great concern today. Purpose: In this study, subacute effect due to co-exposure to low-dose silica nanoparticles (SiNPs) and lead acetate (Pb) on cardiovascular system was detected in Sprague Dawley male rats. Materials and Methods: Histopathological and ultrastructural changes of heart, aortic arch and abdominal aorta were detected. Blood routine and blood biochemistry examinations were used to show the changes of blood components...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/30538058/cardiac-valve-calcification-and-use-of-anticoagulants-preliminary-observation-of-a-potentially-modifiable-risk-factor
#20
Luca Di Lullo, Giovanni Tripepi, Claudio Ronco, Graziella D'Arrigo, Vincenzo Barbera, Domenico Russo, Biagio Raffaele Di Iorio, Massimo Uguccioni, Ernesto Paoletti, Maura Ravera, Maria Fusaro, Antonio Bellasi
AIMS: Direct oral anticoagulant (DOAC) has been recently introduced in the clinical practice. Rather than interfering with vitamin K-dependent posttranscriptional modification of various proteins, DOACs selectively inhibit factors involved in the coagulation cascade. In particular, in contrast with Warfarin, Rivaroxabn does not interfere with activation of matrix Gla Protein (MGP), a potent vascular calcification Inhibitor. We herein sought to investigate the impact of Rivaroxaban and Warfarin on cardiac valve calcifications in a cohort of moderate-to advanced CKD patients...
November 29, 2018: International Journal of Cardiology
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