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https://www.readbyqxmd.com/read/27904617/the-interferon-lambda-4-rs368234815-predicts-treatment-response-to-pegylated-interferon-alpha-and-ribavirin-in-hemophilic-patients-with-chronic-hepatitis-c
#1
Maryam Keshvari, Seyed Moayed Alavian, Bita Behnava, Ali Pouryasin, Heidar Sharafi
BACKGROUND: A dinucleotide variant rs368234815 in interferon lambda 4 (IFNL4) gene was recently found to be associated with the hepatitis C virus (HCV) treatment response. This study aimed to assess the impact of IFNL4 rs368234815 polymorphism on treatment response to pegylated-IFN alpha (Peg-IFN-α) and ribavirin (RBV) in hemophilic patients with chronic hepatitis C (CHC). MATERIALS AND METHODS: In this retrospective study, 92 hemophilic patients with CHC who were treated with Peg-IFN-α/RBV were investigated...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27902551/do-years-of-experience-with-electronic-health-records-matter-for-productivity-in-community-health-centers
#2
Bianca K Frogner, Xiaoli Wu, Leighton Ku, Patricia Pittman, Leah E Masselink
This study investigated how years of experience with an electronic health record (EHR) related to productivity in community health centers (CHCs). Using data from the 2012 Uniform Data System, we regressed average annual medical visits, weighted for service intensity, as a function of full-time equivalent medical staff controlling for CHC size and location. Physician productivity significantly improved. Although the productivity of all other staff types was not significantly different by years of EHR experience, the trends showed lower productivity among nurses and other medical staff in CHCs with fewer years of EHR experience versus more years of experience...
January 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/27902550/-salt-in-the-wound-safety-net-clinician-perspectives-on-performance-feedback-derived-from-ehr-data
#3
Arwen E Bunce, Rachel Gold, James V Davis, MaryBeth Mercer, Victoria Jaworski, Celine Hollombe, Christine Nelson
Electronic health record (EHR) data can be extracted for calculating performance feedback, but users' perceptions of such feedback impact its effectiveness. Through qualitative analyses, we identified perspectives on barriers and facilitators to the perceived legitimacy of EHR-based performance feedback, in 11 community health centers (CHCs). Providers said such measures rarely accounted for CHC patients' complex lives or for providers' decisions as informed by this complexity, which diminished the measures' perceived validity...
January 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/27899153/can-integrated-health-services-delivery-have-an-impact-on-hypertension-management-a-cross-sectional-study-in-two-cities-of-china
#4
Haitao Li, Ying Sun, Dongfu Qian
BACKGROUND: Policy makers require information regarding performance of different primary care delivery models in managing hypertension, which can be helpful for better hypertension management. This study aims to compare continuity of care among hypertensive patients between Direct Management (DM) Model of community health centers (CHCs) in Wuhan and Loose Collaboration (LC) Model in Nanjing. METHODS: A cross-sectional questionnaire survey was conducted. Four CHCs in each city were randomly selected as study settings...
November 30, 2016: International Journal for Equity in Health
https://www.readbyqxmd.com/read/27896409/post-resection-prognosis-of-combined-hepatocellular-carcinoma-cholangiocarcinoma-according-to-the-2010-who-classification
#5
Dong-Hwan Jung, Shin Hwang, Seung-Mo Hong, Yong-Kyu Chung, Gi-Won Song, Young-Joo Lee, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gil-Chun Park, Han Chu Lee, Young-Suk Lim, Eun Sil Yu, Sung-Gyu Lee
BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cHC) has wide histological diversity. We intended to investigate the prognostic influence of tumor types of cHC. METHODS: We analyzed the clinical and pathological features of cHC along 2010 WHO classification. Study group was 100 cHC patients who underwent primary resection. Control group comprised 200 propensity score-matched patients with intrahepatic cholangiocarcinoma (ICC). RESULTS: In cHC group, tumor diameter was 4...
November 28, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27888401/the-impact-of-chronic-hepatitis-c-infection-on-cholesterol-metabolism-in-pbmcs-is-associated-with-microrna-146a-expression
#6
M Sidorkiewicz, M Grek, B Jozwiak, A Krol, A Piekarska
Chronic hepatitis C (CHC) infection is known to induce important changes in host cholesterol metabolism. MicroRNAs (miRNAs) regulate the expression of many genes and, in consequence, control various processes, including human metabolism and response to viral infection. Recently, the alteration of the immune-associated miR-146a, which is abundantly present in peripheral blood mononuclear cells (PBMCs), was found in some viral infections. The study aimed to analyse the influence of hepatitis C virus (HCV) infection on miR-146a expression in PBMCs in vivo and in vitro, as well as to assess the possible impact of miR-146a alteration on the intracellular cholesterol level in PBMCs...
November 25, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27884423/alterations-in-a-unique-class-of-cortical-chandelier-cell-axon-cartridges-in-schizophrenia
#7
Brad R Rocco, Adam M DeDionisio, David A Lewis, Kenneth N Fish
BACKGROUND: The axons of chandelier cells (ChCs) target the axon initial segment of pyramidal neurons, forming an array of boutons termed a cartridge. In schizophrenia, the density of cartridges detectable by gamma-aminobutyric acid (GABA) membrane transporter 1 immunoreactivity is lower, whereas the density of axon initial segments detectable by immunoreactivity for the α2 subunit of the GABAA receptor is higher in layers 2/superficial 3 of the prefrontal cortex. These findings were interpreted as compensatory responses to lower GABA levels in ChCs...
September 29, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27882162/evaluation-of-the-health-related-quality-of-life-using-the-36-item-short-form-health-survey-in-patients-with-chronic-hepatitis-c-receiving-pegylated-interferon-ribavirin-telaprevir-triple-treatment
#8
Mitsuyuki Suzuki, Toru Ishikawa, Ai Sakuma, Satoshi Abe, Hiroko Abe, Fujiko Koyama, Tomomi Nakano, Aya Ueki, Hirohito Noguchi, Erina Hasegawa, Shiori Yamagata, Miki Kobayashi, Kazutaka Ohashi, Hiroshi Hirosawa, Takako Fukazawa, Yuka Maruyama, Toshiaki Yoshida
The rate of sustained virologic response (SVR) has increased in patients with chronic hepatitis C (CHC; genotype 1) since triple treatment with pegylated interferon (PEG-IFN), ribavirin (RBV) and telaprevir (TVR) was included in Japanese health insurance. However, side effects such as high-grade anemia and skin disorders means it is important to investigate the extent to which quality of life (QOL) is maintained during treatment. The impact on health-related (HR) QOL, as a result of TVR-based triple treatment was investigated long-term (48 weeks) in 34 patients (18 men, 16 women) following TVR-based triple treatment, using the 36-item short form health survey (SF-36)...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27877087/il28b-snp-rs12979860-is-the-critical-predictor-for-sustained-viral-response-in-chinese-children-aged-1-to-6-years-with-chronic-hepatitis-c
#9
Yan-Wei Zhong, Hong-Fei Zhang, Yan-Min Shi, Yong-Li Li, Fang Chu, Zhi-Qiang Xu, Da-Wei Chen, Yu Gan, Fu-Chuan Wang, Mei-Lei Gu, Yi Dong, Shi-Shu Zhu, Ce Shi, Hua-Hao Fan, Xiu-Chang Zhang, Min Zhang
Clinical data on children with chronic hepatitis C (CHC) remain extremely limited. This study investigated sustained virologic response (SVR) to alfa-interferon 2b plus RBV treatment in children aged 1-6 years with unsafe injection-acquired CHC. 154 children with CHC aged 1 to 6 years were enrolled, 101 of them were male (65.6%) and 53 were female (34.4%), and they were treated with alfa-interferon at a dose of 1-5 MIU/m(2) 3 times weekly plus oral RBV (15 mg/kg/day) for 48 weeks. 57(39.3 %) of them were genotype 1b, 73(50...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27870883/association-between-leptin-and-complement-in-hepatitis-c-patients-with-viral-clearance-homeostasis-of-metabolism-and-immunity
#10
Ming-Ling Chang, Chia-Jung Kuo, Hsin-Chih Huang, Yin-Yi Chu, Cheng-Tang Chiu
BACKGROUND: The association between leptin and complement in hepatitis C virus (HCV) infection remains unknown. METHODS: A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels...
2016: PloS One
https://www.readbyqxmd.com/read/27854559/the-influence-of-cyclic-hormonal-contraception-on-expression-of-premenstrual-syndrome
#11
Kimberly A Yonkers, Brianna Cameron, Ralitza Gueorguieva, Margaret Altemus, Susan G Kornstein
BACKGROUND: Some women who use cyclic hormonal contraception (CHC) suffer from premenstrual symptoms; whether their symptoms differ from women who do not use CHC is not clear. OBJECTIVE: To compare women who use or do not use CHC on perimenstrual symptom timing and change severity. STUDY DESIGN: We analyzed daily symptom ratings from women who requested participation in (Screened Cohort: 103 used CHC and 387 did not) or were randomized in (Randomized Cohort: 41 used CHC and 211 did not) a clinical trial for premenstrual syndrome...
November 17, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27833930/prognostic-value-of-transient-elastography-in-human-immunodeficiency-virus-infected-patients-with-chronic-hepatitis-c
#12
Leire Pérez-Latorre, Antonio Rivero-Juárez, Víctor Hontañón, Cristina Díez, Francisca Cuenca, Maria Luz Martín-Carbonero, María L Montes, José M Bellón, Teresa Aldámiz-Echevarría, Ana Carrero, Antonio Rivero, Juan González-García, Juan Berenguer
BACKGROUND: Our objective was to study the prognostic value of liver stiffness (LS) in HIV-infected patients with chronic hepatitis C (CHC). METHODS: We analyzed HIV-infected patients with compensated CHC and at least 1 determination of LS. The primary outcome was the occurrence of liver-related events (LRE), namely, decompensation or hepatocellular carcinoma, whichever occurred first. We selected patients without sustained viral response (SVR) or end-of-treatment response (ETR) during follow-up and allocated them to an estimation cohort (EC) and a validation cohort (VC)...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27832346/species-specific-cuticular-hydrocarbon-stability-within-european-myrmica-ants
#13
Rhian M Guillem, Falko P Drijfhout, Stephen J Martin
Recognition is a fundamental process on which all subsequent behaviors are based at every organizational level, from the gene up to the super-organism. At the whole organism level, visual recognition is the best understood. However, chemical communication is far more widespread than visual communication, but despite its importance is much less understood. Ants provide an excellent model system for chemical ecology studies as it is well established that compounds known as cuticular hydrocarbons (CHCs) are used as recognition cues in ants...
November 10, 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27831726/woodcock-johnson-iii-kaufman-adolescent-and-adult-intelligence-test-kait-kaufman-assessment-battery-for-children-kabc-and-differential-ability-scales-das-support-carroll-but-not-cattell-horn
#14
Jeffrey M Cucina, Garett N Howardson
Recently emerging evidence suggests that the dominant structural model of mental abilities-the Cattell-Horn-Carroll (CHC) model-may not adequately account for observed scores for mental abilities batteries, leading scholars to call into question the model's validity. Establishing the robustness of these findings is important since CHC is the foundation for several contemporary mental abilities test batteries, such as the Woodcock-Johnson III (WJ-III). Using confirmatory factor analysis, we investigated CHC's robustness across 4 archival samples of mental abilities test battery data, including the WJ-III, the Kaufman Adolescent & Adult Intelligence Test (KAIT), the Kaufman Assessment Battery for Children (KABC), and the Differential Ability Scales (DAS)...
November 10, 2016: Psychological Assessment
https://www.readbyqxmd.com/read/27830380/recovery-of-pan-genotypic-and-genotype-specific-amino-acid-alterations-in-chronic-hepatitis-c-after-viral-clearance-transition-at-the-crossroad-of-metabolism-and-immunity
#15
Ming-Ling Chang, Mei-Ling Cheng, Su-Wei Chang, Hsiang-Yu Tang, Cheng-Tang Chiu, Chau-Ting Yeh, Ming-Shi Shiao
Recovery of amino acid (AA) metabolism and the associated clinical implications in chronic hepatitis C (CHC) patients with sustained virological response (SVR) following anti-hepatitis C virus (HCV) therapy remains elusive. A prospective cohort study was conducted on 222 CHC patients with SVR. Eighty-two age-matched male genotype 1 (G1) and G2 patients underwent paired serum metabolomics analyses with liquid chromatography-tandem mass spectrometry to examine AAs before and 24 weeks after anti-HCV therapy. Before anti-HCV therapy, G1 patients had a higher HCV RNA level than G2 patients...
November 10, 2016: Amino Acids
https://www.readbyqxmd.com/read/27823942/combined-hormonal-contraceptive-chc-use-among-obese-women-and-contraceptive-effectiveness-a-systematic-review
#16
REVIEW
Monica V Dragoman, Katharine B Simmons, Melissa E Paulen, Kathryn M Curtis
OBJECTIVE: To evaluate from the literature whether combined hormonal contraception (CHC), including combined oral contraception pills (COC), transdermal patch, vaginal ring, or combined injectables, have different effectiveness or failure rates by body weight or body mass index (BMI). STUDY DESIGN: We searched PubMed and the Cochrane Library databases for all articles in all languages published between inception and February 2016, for evidence relevant to body weight or BMI, CHC use and contraceptive effectiveness...
November 4, 2016: Contraception
https://www.readbyqxmd.com/read/27818433/can-text-messages-improve-attendance-to-primary-care-appointments-in-underserved-populations
#17
Sanja Percac-Lima, Daniel E Singer, Patrick R Cronin, Yuchiao Chang, Adrian H Zai
We explored whether text message (TM) reminders could be used at a community health center (CHC) to improve primary care appointment attendance in adult patients. Over six months, we allocated 8,425 appointments to intervention and 2,679 to control. The proportion of no-shows in the intervention was 18.0% vs. 19.8% in control (p = .106). Among intervention appointments, 1,431 did not have a cell phone, 4,955 did not respond to the consent TM, and 231 declined TMs. The proportion of no-shows for the 1,309 appointments who received TM was 13...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27805898/accuracy-of-transient-elastography-in-the-assessment-of-chronic-hepatitis-c-related-liver-cirrhosis
#18
Hai-Yan Ying, Lun-Gen Lu, Da-Dao Jing, Xiu-Shi Ni
PURPOSE: Staging liver cirrhosis is essential for the management of chronic hepatitis C (CHC). The current meta-analysis evaluated the accuracy of transient elastography for detecting liver cirrhosis in patients with CHC. METHODS: Either prospective or retrospective studies, including cohort and cross sectional studies, in patients diagnosed with chronic hepatitis C, as assessed by transient elastography, were searched from Medline, Cochrane, EMBASE, and Google Scholar databases until March 3, 2015, using the terms "transient elastography, chronic hepatitis C and liver cirrhosis"...
October 14, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27803742/direct-acting-antivirals-for-the-treatment-of-chronic-hepatitis-c-in-patients-with-chronic-kidney-disease
#19
REVIEW
Anita Kohli, Ali Alshati, Fawaz Georgie, Richard Manch, Robert G Gish
All-oral, direct-acting antivirals (DAAs) have significantly improved the efficacy and safety of chronic hepatitis C (CHC) treatment but their effectiveness and safety among patients with chronic kidney disease (CKD) remains poorly understood. Our aim was to assess the efficacy and safety of DAAs for treatment of CKD patients. The National Library of Medicine through PubMed was searched for studies evaluating the efficacy of DAAs for the treatment of patients with CKD stages 4 or 5, as defined by the Kidney Disease Outcomes Quality Initiative guidelines [i...
November 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27803168/mortality-in-patients-with-chronic-hepatitis-c-and-cirrhosis-compared-to-the-general-population-a-danish-cohort-study
#20
Sofie Hallager, Peer Brehm Christensen, Steen Ladelund, Mette Rye Clausen, Alex Lund Laursen, Axel Møller, Poul Schlicthting, Lone Galmstrup Madsen, Jan Gerstoft, Suzanne Lunding, Karin Elmegaard Grønbæk, Henrik Bygum Krarup, Nina Weis
BACKGROUND:  Knowledge of mortality in patients with Chronic Hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause mortality among CHC patients with and without cirrhosis in Denmark compared to the general population. METHODS:  Patients registered in The Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was based on liver biopsy, transient elastography, and clinical cirrhosis...
October 31, 2016: Journal of Infectious Diseases
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