Read by QxMD icon Read


T V Lisovskaya, G B Mal'gina, T A Perepletina, M A Chistyakov, I V Dan'kova, O A Melkozerova
AIM: The purpose of the study was to investigate the morphological features of endometrium in patients with viral hepatitis type C. MATERIALS AND METHODS: A morphological survey was conducted involving endometrium sections stained with hematoxylin and eosin and Van Gieson's picrofuchsin collected from 140 women of reproductive age, among them 70 patients were diagnosed with chronic hepatitis type C (CHC) infection with minimal (40 patients) and moderate activity (30 patients), and 70 women suffered from endometrial proliferative diseases without viral hepatitis (comparison group)...
October 2016: Gynecological Endocrinology
Yone-Han Mah, Chen-Hua Liu, Chi-Ling Chen, Tai-Chung Tseng, Chun-Jen Liu, Pei-Jer Chen, Ding-Shinn Chen, Jia-Horng Kao
BACKGROUND/PURPOSE: Clinical implications of IL28B gene in Taiwanese chronic hepatitis C (CHC) patients remain unknown. We thus investigated the prevalence and clinical implications of IL28B rs8099917 genotypes in CHC patients with different hepatitis C virus (HCV) genotypes and healthy controls. METHODS: A total of 200 HCV genotype 1 patients and 200 HCV genotype 2 patients who received liver biopsy, as well as 197 healthy controls were enrolled to determine the frequencies of IL28B rs8099917 genotypes...
October 14, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Zobair M Younossi, Atsushi Tanaka, Yuichiro Eguchi, Young-Suk Lim, Ming-Lung Yu, Norifumi Kawada, Yock Young Dan, Craig Brooks-Rooney, Francesco Negro, Mario U Mondelli
Between 80 and 115 million people worldwide are chronically infected with hepatitis C virus, with 60-90% of these being undiagnosed. Untreated chronic hepatitis C (CHC) is associated with progressive liver disease, cirrhosis, hepatocellular carcinoma and liver-related mortality. A number of extrahepatic manifestations are also reported in CHC patients, further adding to the burden of the disease. CHC also impacts patients in terms of lower health-related quality of life, higher levels of fatigue and reduced productivity...
October 17, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Emmanuel Ssemmondo, Florence Mwangwa, Joel L Kironde, Dalsone Kwarisiima, Tamara D Clark, Carina Marquez, Edwin D Charlebois, Maya L Petersen, Moses R Kamya, Diane V Havlir, Gabriel Chamie
BACKGROUND: Active tuberculosis (TB) screening outside clinics and in communities may reduce undiagnosed TB. METHODS: To determine the yield of TB screening during community-based HIV testing campaigns (CHC) in 7 rural Ugandan communities within an ongoing cluster-randomized trial of universal HIV testing and treatment (SEARCH, NCT:01864603), we offered sputum microscopy to participants with prolonged cough (>2 weeks). We determined the number of persons needed to screen to identify one TB case, and the number of cases identified that linked to clinic and completed TB treatment...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Wei Chang, Gabriel Chamie, Daniel Mwai, Tamara D Clark, Harsha Thirumurthy, Edwin D Charlebois, Maya Petersen, Jane Kabami, Emmanuel Ssemmondo, Kevin Kadede, Dalsone Kwarisiima, Norton Sang, Elizabeth A Bukusi, Craig R Cohen, Moses Kamya, Diane V Havlir, James G Kahn
BACKGROUND: In 2013-2014, we achieved 89% adult HIV testing coverage using a hybrid testing approach in 32 communities in Uganda and Kenya (SEARCH: NCT01864603). To inform scalability, we sought to determine: (1) overall cost and efficiency of this approach; and (2) costs associated with point-of-care (POC) CD4 testing, multidisease services, and community mobilization. METHODS: We applied microcosting methods to estimate costs of population-wide HIV testing in 12 SEARCH trial communities...
November 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Po-Chun Chang, Yi-Chi Chao, Meng-Hsuan Hsiao, Hao-Syun Chou, Yi-Han Jheng, Xin-Hong Yu, Ning Lee, Connie Yang, Dean-Mo Liu
BACKGROUND: Developing a drug carrier with favorable handling characteristics that can respond to environmental changes following inflammation, such as pH changes, may be beneficial for treating periodontitis. This study aimed to investigate the preclinical feasibility of using naringin, a naturally derived polymethoxylated flavonoid compound with anti-inflammatory properties, to inhibit periodontitis induction via a thermo-gelling and pH-responsive injectable hydrogel. METHODS: The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), beta glycerol-phosphate (β-GP), and glycerol, and the thermo-gelling and pH-responsive characteristics of the hydrogel as well as the cell viability after treatment with the hydrogel containing naringin were evaluated in vitro...
October 14, 2016: Journal of Periodontology
Maryam Keshvari, Seyed Moayed Alavian, Bita Behnava, Ali Pouryasin, Johanna C Craig, Heidar Sharafi
BACKGROUND: The aim of this study was to determine whether two polymorphisms of the human interferon lambda 4 (IFNL4) gene (rs12979860 and rs8099917) can predict sustained virologic response (SVR) following antiviral therapy in patients with inherited bleeding disorder and chronic hepatitis C (CHC). METHODS: This retrospective study was conducted on 294 patients with congenital bleeding disorder and CHC who were treated with Peg-Interferon-α (PegIFN) and Ribavirin (RBV)...
October 13, 2016: Journal of Clinical Laboratory Analysis
Ming-Lung Yu, Chung-Feng Huang, Ming-Lun Yeh, Pei-Chien Tsai, Ching-I Huang, Meng-Hsuan Hsieh, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang
Purpose Age and hepatic fibrosis are the factors that increase the risk of hepatocellular carcinoma (HCC) over time. We aimed to explore their impact at the initiation of antiviral therapy on HCC among chronic hepatitis C (CHC) patients. Experimental Design A total of 1281 biopsy-proven CHC patients receiving interferon-based therapy were followed for a mean period of 5.5 years. Results The 5-year cumulative incidence of HCC did not differ between non-SVR and SVR patients who were <40 years old (7.7 % vs...
October 12, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Kevin Appourchaux, Safi Dokmak, Matthieu Resche-Rigon, Xavier Treton, Martine Lapalus, Charles-Henry Gattolliat, Emmanuelle Porchet, Michelle Martinot-Peignoux, Nathalie Boyer, Michel Vidaud, Pierre Bedossa, Patrick Marcellin, Ivan Bièche, Emilie Estrabaud, Tarik Asselah
Staging fibrosis is crucial for the prognosis and to determine the rapid need of treatment in patients with chronic hepatitis B (CHB) and C (CHC). The expression of 13 fibrosis-related microRNAs (miRNAs) (miR-20a, miR-21, miR-27a, miR-27b, miR-29a, miR-29c, miR-92a, miR-122, miR-146a, miR-155, miR-221, miR-222, and miR-224) was analyzed in 194 serums and 177 liver biopsies of patients with either CHB or CHC to develop models to diagnose advanced fibrosis and cirrhosis (Metavir F3-F4). In CHB patients, the model (serum miR-122, serum miR-222, platelet count and alkaline phosphatase) was more accurate than APRI and FIB-4 to discriminate in between mild and moderate fibrosis (F1-F2) and F3-F4 (AUC of CHB model: 0...
October 12, 2016: Scientific Reports
Subhash Rajpurohit, Robert Hanus, Vladimír Vrkoslav, Emily L Behrman, Alan O Bergland, Dmitri Petrov, Josef Cvačka, Paul S Schmidt
Cuticular hydrocarbons (CHCs) are hydrophobic compounds deposited on the arthropod cuticle that are of functional significance with respect to stress tolerance, social interactions, and mating dynamics. We characterized CHC profiles in natural populations of Drosophila melanogaster at five levels: across a latitudinal transect in the eastern U.S., as a function of developmental temperature during culture, across seasonal time in replicate years, and as a function of rapid evolution in experimental mesocosms in the field...
October 8, 2016: Journal of Evolutionary Biology
Parvaneh Sedighimehr, Shiva Irani, Fatemeh Sakhaee, Farzam Vaziri, Mohammadreza Aghasadeghi, Seyed Mehdi Sadat, Fatemeh Rahimi Jamnani, Abolfazl Fateh, Seyed Davar Siadat
Single-nucleotide polymorphisms (SNPs) in the Interleukin-28B (IL28B) gene and rs4273729 in the human leukocyte antigen (HLA) gene in chronic hepatitis C (CHC) virus infection are important for predicting treatment outcome. In this study, the distribution of IL28B SNPs (rs12979860 and rs12980275) and HLA rs4273729 in rapid virologic response (RVR), complete early virologic response (cEVR) and sustained virologic response (SVR) in HCV Iranian patients with CHC virus infection was assessed. IL28B genotyping and rs4273729 were performed using the amplification refractory mutation system (ARMS)-PCR and direct sequencing in 190 CHC virus infections, respectively...
October 6, 2016: Archives of Virology
Ali Ugur Uslu, Bahattin Aydin, Sevket Balta, Ozlem Yonem, Tunahan Uncu, Dogan Seven
INTRODUCTION: Chronic hepatitis C (CHC) infection is a systemic disorder that can lead to liver inflammation, fibrosis, cirrhosis, and hepatocellular cancer. The mean platelet volume (MPV) is widely used as an inflammatory marker to evaluate the platelet function and the status of systemic inflammation. AIM: To determine the pre- and post-treatment MPV values in CHC patients who were administered a 48-week antiviral therapy based on systemic inflammation. MATERIAL AND METHODS: We enrolled 28 patients, diagnosed with CHC genotype 1b, who received a 48-week antiviral therapy and attended regular follow-up, and 28 healthy individuals...
2016: Przegla̜d Gastroenterologiczny
María Batuecas, Ruth Castro-Rodrigo, Miguel A Esteruelas, Cristina García-Yebra, Ana M López, Enrique Oñate
The aromatic osmacyclopropenefuran bicycles [OsTp{κ(3) -C(1) ,C(2) ,O-(C(1) H2 C(2) CHC(OEt)O)}(P(i) Pr3 )]BF4 (Tp=hydridotris(1-pyrazolyl)borate) and [OsH{κ(3) -C(1) ,C(2) ,O-(C(1) H2 C(2) CHC(OEt)O)}(CO)(P(i) Pr3 )2 ]BF4 , with the metal fragment in a common vertex between the fused three- and five-membered rings, have been prepared via the π-allene intermediates [OsTp(η(2) -CH2 =CCHCO2 Et)(OCMe2 )(P(i) Pr3 )]BF4 and [OsH(η(2) -CH2 =CCHCO2 Et)(CO)(OH2 )(P(i) Pr3 )2 ]BF4 , and their aromaticity analyzed by DFT calculations...
October 4, 2016: Angewandte Chemie
Shi-Yi Wang, Melissa D Aldridge, Maureen Canavan, Emily Cherlin, Elizabeth Bradley
OBJECTIVES: To identify hospice and patient characteristics associated with the use of continuous home care (CHC), and to examine the associations between CHC utilization and hospice disenrollment or hospitalization after hospice enrollment. METHODS: Using 100% fee-for-service Medicare claims data for beneficiaries aged 66 years or older who died between July and December 2011, we identified the percentage of hospice agencies in which patients used CHC in 2011 and determined hospice and patient characteristics associated with use of CHC...
September 30, 2016: Journal of Pain and Symptom Management
M J Nielsen, M A Karsdal, K Kazankov, H Grønbaek, A Krag, D J Leeming, D Schuppan, J George
BACKGROUND: While morphological patterns differ, the molecular phenotype of liver fibrosis is considered a stereotypical response to chronic liver injury. However, with different cellular triggers and networks regulating fibrosis, the molecular responses of the injured liver may not be identical. AIM: To investigate whether differences in extracellular matrix (ECM) composition of the liver during fibrogenesis in two seemingly similar types of viral hepatitis could be reflected by differences in ECM turnover...
October 3, 2016: Alimentary Pharmacology & Therapeutics
Ecaterina Constanța Barbu, Cristina Emilia Chiţu-Tișu, Mihai Lazăr, Cristina Mihaela Olariu, Dan Olteanu, Mihai Bojincă, Adrian Octavian Abagiu, Victoria Aramă, Daniela Adriana Ion, Ioana Anca Bădărău
AIMS: We aimed to quantify global and regional body composition changes in chronic hepatitis C (CHC) patients, compare them to healthy controls and identify possible association between body composition changes and CHC. To our knowledge, this study is the first one comparing CHC patients to controls with regard to soft tissue body composition changes. METHODS: We assessed 60 CHC patients and 60 healthy controls by Dual Energy X-Ray Absorptiometry. Soft tissue and bone body composition parameters were compared between the groups (using the Mann-Whitney test)...
September 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
Jacqueline A Bachofner, Piero V Valli, Arne Kröger, Irina Bergamin, Patrizia Künzler, Adriana Baserga, Dominique Braun, Burkhardt Seifert, Anja Moncsek, Jan Fehr, David Semela, Lorenzo Magenta, Beat Müllhaupt, Benedetta Terziroli Beretta-Piccoli, Joachim C Mertens
BACKGROUND: Novel direct antiviral agents (DAA) targeting hepatitis C virus (HCV) have revolutionized the treatment of chronic hepatitis C infection (CHC). Rates of sustained virological response (SVR) to treatment have drastically improved since introduction of DAA. Transient Elastography (TE) is an ultrasound based, non-invasive technique to assess liver stiffness (LS). We examined the changes in TE values and fibrosis scores FIB-4 and APRI after DAA treatment of CHC. METHODS: 549 patients who received a DAA based treatment for CHC were screened and 392 were included...
September 28, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Regine Sitruk-Ware
The safety of combined hormonal contraceptives (CHCs) has been documented by years of follow-up, and the occurrence of venous thromboembolism (VTE) possibly related to their use is rare in the young population exposed to these agents. The balance between the benefits and risks of contraceptive steroids is generally positive, in particular when compared with pregnancy's risks. Epidemiological studies led to different results showing either no difference in VTE risk between CHCs (active surveillance prospective studies) or an increase in risk (observational or database studies)...
September 24, 2016: Fertility and Sterility
Jonas Finck, Emma L Berdan, Frieder Mayer, Bernhard Ronacher, Sven Geiselhardt
Cuticular hydrocarbons (CHCs) play a major role in the evolution of reproductive isolation between insect species. The CHC profiles of two closely related sympatric grasshopper species, Chorthippus biguttulus and C. mollis, differ mainly in the position of the first methyl group in major methyl-branched CHCs. The position of methyl branches is determined either by a fatty acid synthase (FAS) or by elongases. Both protein families showed an expansion in insects. Interestingly, the FAS family showed several lineage-specific expansions, especially in insect orders with highly diverse methyl-branched CHC profiles...
September 28, 2016: Scientific Reports
Belinda K Mössner, Benjamin Staugaard, Janne Jensen, Søren Thue Lillevang, Peer B Christensen, Dorte Kinggaard Holm
AIM: To detect chronic hepatitis B (CHB), chronic hepatitis C (CHC) and human immunodeficiency virus (HIV) infections in dried blood spot (DBS) and compare these samples to venous blood sampling in real-life. METHODS: We included prospective patients with known viral infections from drug treatment centers, a prison and outpatient clinics and included blood donors as negative controls. Five drops of finger capillary blood were spotted on filter paper, and a venous blood sample was obtained...
September 7, 2016: World Journal of Gastroenterology: WJG
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"