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https://www.readbyqxmd.com/read/29786879/comorbidity-of-viral-hepatitis-and-chronic-spontaneous-urticaria-a-systematic-review
#1
REVIEW
Pavel Kolkhir, Natalia Pereverzina, Olga Olisova, Marcus Maurer
Chronic viral infections including those by hepatitis B (CHB) virus and hepatitis C (CHC) virus have been reported to be comorbidities of chronic spontaneous urticaria (CSU). Here, we performed the first comprehensive review of the peer-reviewed literature (Pubmed, Web of Science and Google Scholar) on the prevalence of CHB and CHC in patients with CSU and vice versa. The prevalence of CHB and CHC in CSU does not appear to be increased. Less than 5% and less than 2% of CSU patients have markers of CHB and CHC, respectively, according to most of the 32 studies reviewed...
May 22, 2018: Allergy
https://www.readbyqxmd.com/read/29785627/chemical-communication-and-reproduction-partitioning-in-social-wasps
#2
REVIEW
Francesca Romana Dani, Stefano Turillazzi
Social wasps encompass species displaying diverse social organization regarding colony cycle, nest foundation, caste differences (from none to significant dimorphism) and number of reproductive queens. Current phylogenetic data suggests that sociality occured independently in the subfamily Stenogastrinae and in the Polistinae+Vespinae clade. In most species, including those with the simplest social organization, colony reproduction is monopolised by a single or few females. Since their nest mates can also develop ovaries and lay eggs, dominant females must somehow inhibit them from reproducing...
May 22, 2018: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29783670/adult-premenopausal-bone-health-related-to-reproductive-characteristics-population-based-data-from-the-canadian-multicentre-osteoporosis-study-cam-os
#3
Azita Goshtasebi, Claudie Berger, Susan I Barr, Christopher S Kovacs, Tanveer Towheed, K Shawn Davison, Jerilynn C Prior
Amenorrhea is important for women's bone health. However, few have reported reproductive, anthropometric (body mass index [BMI], height) and bone health (areal bone mineral density [BMD], prevalent fractures) in a population-based study. The purposes of this cross-sectional study of women in the randomly-selected Canadian Multicentre Osteoporosis Study (CaM os ) population were: (1) to describe reproductive, demographic, anthropometric and lifestyle variables; and (2) in menstruating women, to relate reproductive and other variables to BMD at the lumbar spine (L1-4, LS), femoral neck (FN) and total hip (TH) sites and to prevalent fragility fractures...
May 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29780566/nontrigonal-constraint-enhances-1-2-addition-reactivity-of-phosphazenes
#4
Yi-Chun Lin, James C Gilhula, Alexander T Radosevich
The syntheses and 1,2-addition reactivities of nontrigonal phosphazenes supported by trianionic tricoordinating chelates of the type L3 P 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 Ndipp ( 3 : L3 = N[CHC( t Bu)O]2 3- ; 4 : L3 = N( o -NMeC6 H4 )2 3- ; dipp = 2,6-diisopropylphenyl) are reported...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29777168/the-genetic-basis-of-female-pheromone-differences-between-drosophila-melanogaster-and-d-simulans
#5
Jessica A Pardy, Howard D Rundle, Mark A Bernards, Amanda J Moehring
Chemical signals are one means by which many insect species communicate. Differences in the combination of surface chemicals called cuticular hydrocarbons (CHCs) can influence mating behavior and affect reproductive isolation between species. Genes influencing three CHC compounds have been identified in Drosophila melanogaster. However, the genetic basis of other CHC compounds, whether these genes affect species differences in CHCs, and the genes' resulting effect on interspecies mating, remains unknown. We used fine-scale deficiency mapping of the third chromosome to identify 43 genomic regions that influence production of CHCs in both D...
May 19, 2018: Heredity
https://www.readbyqxmd.com/read/29771741/impacts-of-the-affordable-care-act-on-community-health-centers-characteristics-of-new-patients-and-early-changes-in-delivery-of-care
#6
Brigit Hatch, Ning Smith, Mary Ann McBurnie, Thu Quach, Kenneth H Mayer, Mary J Dunne, Erika Cottrell
The aim of this study was to assess the impact of the Affordable Care Act (ACA) on community health centers (CHCs). Using electronic health records from the Community Health Applied Research Network, we assessed new patient characteristics, office visit volume, and payer distribution among CHC patients before and after ACA implementation, 2011-2014 (n = 442 455). New patients post-ACA were younger, more likely to be female and have chronic health conditions, and utilized more primary care (P < .05 for each)...
May 15, 2018: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/29769406/spindle-assembly-disruption-and-cancer-cell-apoptosis-with-a-cltc-binding-compound
#7
Michael J Bond, Marina Bleiler, Lauren E Harrison, Eric W Scocchera, Masako Nakanishi, Narendran G-Dayanandan, Santosh Keshipeddy, Daniel W Rosenberg, Dennis L Wright, Charles Giardina
AK3 compounds are mitotic-arrest agents that induce high levels of γH2AX during mitosis and apoptosis following release from arrest. We synthesized a potent AK3 derivative, AK306, that induced arrest and apoptosis of the HCT116 colon cancer cell line with an EC50 of ~50 nM. AK306 was active on a broad spectrum of cancer cell lines with total growth inhibition values ranging from ~25 nM to 25 µM. Using biotin and BODIPY-linked derivatives of AK306, binding to clathrin heavy chain (CLTC/CHC) was observed, a protein with roles in endocytosis and mitosis...
May 16, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29769038/impact-of-new-daa-therapy-on-real-clinical-practice-a-multicenter-region-wide-cohort-study
#8
Simone Lanini, Paola Scognamiglio, Alessandra Mecozzi, Lorella Lombardozzi, Vincenzo Vullo, Mario Angelico, Antonio Gasbarrini, Gloria Taliani, Adolfo Francesco Attili, Carlo Federico Perno, Adriano De Santis, Vincenzo Puro, Fabio Cerqua, Gianpiero D'Offizi, Adriano Pellicelli, Orlando Armignacco, Francesco Saverio Mennini, Massimo Siciliano, Enrico Girardi, Vincenzo Panella, Giuseppe Ippolito
BACKGROUND: Management of chronic hepatitis C (CHC) has significantly accelerated in the last few years. Currently, second generation direct acting antivirals (DAAs) promise clearance of infection in most of patients. Here we present the results of the first analysis carried out on data of Lazio clinical network for DAAs. METHODS: The study was designed as a multicenter cohort: a) to assess the evolution of treatment during the first 24 months of the activity of the Clinical Network; b) to report overall efficacy of treatments; c) to analyze potential factors associated with lack of virological response at 12 weeks after therapy (SVR12); d) to evaluate the variation of ALT at baseline and 12 weeks after therapy in those who achieved SVR12 in comparison to those who did not...
May 16, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29768686/prevalence-and-predictive-factors-of-moderate-severe-liver-steatosis-in-chronic-hepatitis-c-chc-infected-patients-evaluated-with-controlled-attenuation-parameter-cap
#9
Ana Carolina Cardoso, Renata M Perez, Claudio de Figueiredo-Mendes, Nathalie Carvalho Leite, Henrique Sergio Moraes Coelho, Cristiane A Villela-Nogueira
A novel controlled attenuation parameter (CAP) using FibroScan® has been developed for assessment of liver steatosis. The aim was to evaluate the frequency and associated factors for moderate/severe steatosis evaluated by CAP in CHC patients submitted to transient elastography (TE) by FibroScan® . CHC patients underwent TE with CAP evaluation. The classification of steatosis was defined as: CAP < 222 dB/m = S0; CAP ≥ 222 dB/m and <233dB /m = S1; ≥233 dB/m <290dB/m = S2 and >= 290 dB/m = S3...
May 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29766795/carboxymethyl-hexanoyl-chitosan-nanodroplets-for-ultrasonic-imaging-and-drug-delivery-to-tumor
#10
Yu Jinsui, Situ Bing, Luo Muhua, Li Yue, Liao Jianyi, Du Meng, Cai Kuan, Yang Chaopin, Zhang Hui, Chen Zhiyi
INTRODUCTION: Although a great many strategies have been proposed for tumor-targeted chemotherapy, current delivery methods of anticancer drugs present limited success with inevitable systemic toxicity. The aim of this study was to develop a new kind of theranostic carrier for targeted tumor therapy. METHODS: Prior to prepare CHC-PFP-DOX, carboxymethyl-hexanoyl chitosan (CHC) was synthesized by acylation of carboxymethyl chitosan. To develop CHC-PFP, perfluoropentane (PFP), an ultrasound gas precursor, were simultaneously encapsulated into the hydrophobic inner cores of pre-formulated CHC micelle in aqueous phase via using the oil in water (O/W) emulsion method...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29760760/differences-in-the-reliance-on-cuticular-hydrocarbons-as-sexual-signaling-and-species-discrimination-cues-in-parasitoid-wasps
#11
Jan Buellesbach, Sebastian G Vetter, Thomas Schmitt
Background: Cuticular hydrocarbons (CHC) have been documented to play crucial roles as species- and sex-specific cues in the chemical communication systems of a wide variety of insects. However, whether they are sufficient by themselves as the sole cue triggering sexual behavior as well as preference of con- over heterospecific mating partners is rarely assessed. We conducted behavioral assays in three representative species of parasitoid wasps (Hymenoptera: Pteromalidae) to determine their reliance on CHC as species-specific sexual signaling cues...
2018: Frontiers in Zoology
https://www.readbyqxmd.com/read/29760545/quantitative-assessment-of-hepatic-fibrosis-in-chronic-hepatitis-b-and-c-t1-mapping-on-gd-eob-dtpa-enhanced-liver-magnetic-resonance-imaging
#12
Shen Pan, Xiao-Qi Wang, Qi-Yong Guo
AIM: To assess the accuracy of Look-Locker on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for staging liver fibrosis in chronic hepatitis B/C (CHB/C). METHODS: We prospectively included 109 patients with CHB or CHC who underwent a 3.0-Tesla MRI examination, including T1-weighted and Look-Locker sequences for T1 mapping. Hepatocyte fractions (HeF) and relaxation time reduction rate (RE) were measured for staging liver fibrosis...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29755055/a-multigenerational-strategy-to-transform-health-education-into-community-action
#13
Roma Stovall Hanks, Hattie Myles, Sarah Wraight, Mary C Williams, Candis Patterson, Barbara M Hodnett, Alexandria Broadnax, Shannon Shelley-Tremblay, Errol Crook
BACKGROUND: The National Institute for Minority Health and Health Disparities funded Centers of Excellence to address health disparities through research, education and professional training, and community engagement. This article summarizes a decade of multigenerational educational programing embedded in the Community Engagement Core (CEC) of the National Institute for Minority Health and Health Disparities-funded Center for Healthy Communities-Center of Excellence at the University of South Alabama...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29755014/diagnosis-of-cirrhosis-in-patients-with-chronic-hepatitis-c-genotype-4-role-of-abcb11-genotype-polymorphism-and-plasma-bile-acid-levels
#14
Tarek Besheer, Mona Arafa, Mohamed Abd El-Maksoud, Hatem Elalfy, Amany Hasson, Khaled Zalata, Wagdi Elkashef, Heba Elshahawy, Doaa Raafat, Wafaa Elemshaty, Eman Elsayed, Hosam Zaghloul, Ahmed Abdel Razek, Mahmoud El-Bendary
BACKGROUND/AIMS: Chronic hepatitis C (CHC)-related mortality generally results from cirrhosis and subsequent complications. We aimed to investigate the potential role of plasma bile acid levels and ABCB11 1331T > C (V444A, rs2287622) (ATP-binding cassette subfamily B, member 11) gene polymorphism in fibrosis prediction in CHC genotype 4 patients. MATERIALS AND METHODS: This case control study included 85 healthy control and the following 225 subjects: 170 adult patients infected with hepatitis C virus (HCV) and categorized into three groups according to liver biopsy; no fibrosis group (F0) (n=33), early fibrosis group (F1-F2) (n=61), and advanced fibrosis group (F3-F4) (n=76)...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29753054/psoriatic-patients-with-chronic-viral-hepatitis-do-not-have-an-increased-risk-of-liver-cirrhosis-despite-long-term-methotrexate-use-real-world-data-from-a-nationwide-cohort-study-in-taiwan
#15
Kuo-Tung Tang, Yi-Ming Chen, Shih-Ni Chang, Ching-Heng Lin, Der-Yuan Chen
BACKGROUND: Methotrexate (MTX) is commonly used in the treatment of patients with moderate to severe psoriasis. OBJECTIVE: We conducted a nationwide population-based cohort study to investigate the impact of long-term MTX use on the risk of chronic viral hepatitis-related cirrhosis among psoriatic patients in Taiwan. METHODS: This study obtained data from the National Health Insurance Research Database in Taiwan. We identified 2417 psoriatic patients with chronic hepatitis B (CHB) (370 MTX users and 2047 MTX non-users) and 1127 psoriatic patients with chronic hepatitis C (CHC) (174 MTX users and 953 MTX non-users) from January 1, 2000 to December 31, 2010...
May 9, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29750037/simple-score-to-predict-risk-of-hepatocellular-carcinoma-in-chronic-hepatitis-c-patients-with-advanced-fibrosis-after-pegylated-interferon-and-ribavirin-therapy
#16
Ching-Chih Hu, Cheng-Hao Weng, Liang-Che Chang, Chih-Lang Lin, Yen-Ting Chen, Ching-Fang Hu, Man-Chin Hua, Li-Wei Chen, Rong-Nan Chien
Purpose: Eradication of chronic hepatitis C virus (HCV) after interferon-based therapy and its association with the reduction of risk of hepatocellular carcinoma (HCC) in HCV-infected patients with advanced fibrosis is controversial. The study is aimed to develop a simple scoring model for HCC prediction among advanced fibrotic chronic hepatitis C (CHC) patients after pegylated interferon (pegIFN) and ribavirin (RBV) therapy. Patients and methods: We enrolled 271 biopsy-proven CHC patients with advanced fibrosis between 2003 and 2016, and divided them into non-HCC (n=211) and HCC (n=60) groups...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29742994/a-sense-of-obligation-cultural-differences-in-the-experience-of-obligation
#17
Emma E Buchtel, Leo C Y Ng, Ara Norenzayan, Steven J Heine, Jeremy C Biesanz, Sylvia Xiaohua Chen, Michael Harris Bond, Qin Peng, Yanjie Su
In this investigation of cultural differences in the experience of obligation, we distinguish between Confucian Role Ethics versus Relative Autonomy lay theories of motivation and illustrate them with data showing relevant cultural differences in both social judgments and intrapersonal experience. First, when judging others, Western European heritage culture (WEHC) participants (relative to Confucian heritage culture [CHC] participants) judged obligation-motivated actors more negatively than those motivated by agency (Study 1, N = 529)...
May 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29742149/the-il7ra-rs6897932-polymorphism-is-associated-with-progression-of-liver-fibrosis-in-patients-with-chronic-hepatitis-c-repeated-measurements-design
#18
María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalbán, Sonia Vázquez-Morón, Pablo Ryan, Salvador Resino
The polymorphisms at the α-chain of the IL-7 receptor (IL7RA) have been related to T-cell homeostasis and development and may contribute to immune system deregulation. In the present study, we analyzed the association between IL7RA polymorphisms and the progression of liver fibrosis in patients infected with HCV. We carried out a retrospective study with a design consisting of repeated measurements in 187 HCV-infected patients, to study the risk prediction of liver fibrosis progression using genetic factors...
2018: PloS One
https://www.readbyqxmd.com/read/29740031/higher-risk-of-hepatocellular-carcinoma-in-hispanic-patients-with-hepatitis-c-cirrhosis-and-metabolic-risk-factors
#19
Alina Wong, An Le, Mei-Hsuan Lee, Yu-Ju Lin, Pauline Nguyen, Sam Trinh, Hansen Dang, Mindie H Nguyen
The effect of metabolic syndrome on chronic liver diseases other than non-alcoholic fatty liver disease has not been fully elucidated. Our goal was to evaluate if metabolic syndrome increased the risk of liver-related complications, specifically hepatocellular carcinoma (HCC) and decompensation, in cirrhotic chronic hepatitis C (CHC) patients. We conducted a retrospective cohort study of 3503 consecutive cirrhotic CHC patients seen at Stanford University from 1997-2015. HCC developed in 238 patients (8-year incidence 21%) and hepatic decompensation in 448 patients (8-year incidence 61%)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739095/distribution-of-il28b-rs12979860-and-rs8099917-genotypes-in-patients-with-chronic-hepatitis-c-virus-infection-in-tianjin-china
#20
Kunyan Qiao, Congdoanh Trieu, Zhixiao Huo, Yanan Du, Wei Hou
BACKGROUND: Two single-nucleotide polymorphisms (SNPs) rs12979860 (C/T) and rs8099917 (T/G), near the interleukin 28B (IL28B, also known as IFN lambda-3, IFNL3) gene, have a strong association with both spontaneous and treatment-induced hepatitis C virus (HCV) clearance. IL28B polymorphisms have shown a marked differential distribution with regional and ethnic variation. The study aimed to investigate the distribution of IL28B rs12979860 and rs8099917 genotypes in patients with chronic hepatitis C (CHC) in Tianjin, China...
April 1, 2018: Clinical Laboratory
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