Lorena Tuchscherr, Sindy Wendler, Rakesh Santhanam, Juliane Priese, Annett Reissig, Elke Müller, Rida Ali, Sylvia Müller, Bettina Löffler, Stefan Monecke, Ralf Ehricht, Orlando Guntinas-Lichius
Chronic rhinosinusitis (CRS) is a multifactorial infection of the nasal cavity and sinuses. In this study, nasal swabs from control donors (N = 128) and patients with CRS (N = 246) were analysed. Culture methods and metagenomics revealed no obvious differences in the composition of the bacterial communities between the two groups. However, at the functional level, several metabolic pathways were significantly enriched in the CRS group compared to the control group. Pathways such as carbohydrate transport metabolism, ATP synthesis, cofactors and vitamins, photosynthesis and transcription were highly enriched in CRS...
February 13, 2024: International Journal of Molecular Sciences