Annie Handler, Qiyu Zhang, Song Pang, Tri M Nguyen, Michael Iskols, Michael Nolan-Tamariz, Stuart Cattel, Rebecca Plumb, Brianna Sanchez, Karyl Ashjian, Aria Shotland, Bartianna Brown, Madiha Kabeer, Josef Turecek, Michelle M DeLisle, Genelle Rankin, Wangchu Xiang, Elisa C Pavarino, Nusrat Africawala, Celine Santiago, Wei-Chung Allen Lee, C Shan Xu, David D Ginty
Across mammalian skin, structurally complex and diverse mechanosensory end organs respond to mechanical stimuli and enable our perception of dynamic, light touch. How forces act on morphologically dissimilar mechanosensory end organs of the skin to gate the requisite mechanotransduction channel Piezo2 and excite mechanosensory neurons is not understood. Here, we report high-resolution reconstructions of the hair follicle lanceolate complex, Meissner corpuscle, and Pacinian corpuscle and the subcellular distribution of Piezo2 within them...
September 13, 2023: Neuron