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M Ugarte, K Geraki, G Jeffery
We present further analyses of a previous experiment published in 2016 where the distribution, concentration and correlation of iron, zinc, copper and sulphur in the choroid of the eye in young and aged old world primates (Macaca fascicularis) was studied with synchrotron X-ray fluorescence with a 2 μm resolution. The results indicate that iron accumulates in hotspots in the choroid with age with fluorescence intensity ranging from 2- to 7-fold (1002-3752 ppm) the mean level in the choroidal stroma (500 ppm) and maximum iron levels in blood vessel lumina...
October 10, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Martin Pedard, Aurore Quirie, Perle Totoson, Frank Verhoeven, Philippe Garnier, Anne Tessier, Ce'line Demougeot, Christine Marie
No abstract text is available yet for this article.
October 6, 2018: Atherosclerosis
Anatoliy I Yashin, Konstantin G Arbeev, Deqing Wu, Liubov S Arbeeva, Olivia Bagley, Eric Stallard, Alexander M Kulminski, Igor Akushevich, Fang Fang, Mary K Wojczynski, Kaare Christensen, Anne B Newman, Robert M Boudreau, Michael A Province, Stephen Thielke, Thomas T Perls, Ping An, Irma Elo, Svetlana V Ukraintseva
The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studies of human longevity which differed with respect to whether missing lifespan data were predicted or not predicted. We showed that the use of predicted lifespan is most beneficial when the follow-up period is relatively short. In addition to detection of strong associations of SNPs in APOE, TOMM40, NECTIN2, and APOC1 genes with longevity, we also detected a strong new association with longevity of rs1927465, located between the CYP26A1 and MYOF genes on chromosome 10...
October 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Yi Zeng, Chao Nie, Junxia Min, Huashuai Chen, Xiaomin Liu, Rui Ye, Zhihua Chen, Chen Bai, Enjun Xie, Zhaoxue Yin, Yuebin Lv, Jiehua Lu, Jianxin Li, Ting Ni, Lars Bolund, Kenneth C Land, Anatoliy Yashin, Angela M O'Rand, Liang Sun, Ze Yang, Wei Tao, Anastasia Gurinovich, Claudio Franceschi, Jichun Xie, Jun Gu, Yong Hou, Xiao Liu, Xun Xu, Jean-Marie Robine, Joris Deelen, Paola Sebastiani, Eline Slagboom, Thomas Perls, Elizabeth Hauser, William Gottschalk, Qihua Tan, Kaare Christensen, Xiaoming Shi, Mike Lutz, Xiao-Li Tian, Huanming Yang, James Vaupel
IMPORTANCE: Sex differences in genetic associations with human longevity remain largely unknown; investigations on this topic are important for individualized health care. OBJECTIVE: To explore sex differences in genetic associations with longevity. DESIGN SETTING AND PARTICIPANTS: This population-based case-control study used sex-specific genome-wide association study and polygenic risk score (PRS) analyses to examine sex differences in genetic associations with longevity...
August 2018: JAMA network open
(no author information available yet)
No abstract text is available yet for this article.
October 2018: Journal of Dental Education
Bao-Shu Xie, Yi-Qin Wang, Yong Lin, Qing Mao, Jun-Feng Feng, Guo-Yi Gao, Ji-Yao Jiang
AIMS: Ferroptosis, a new form of iron-dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. We aimed to investigate whether ferroptosis is induced after TBI and whether the inhibition of ferroptosis would protect against traumatic brain injury in a controlled cortical impact injury (CCI) mouse model. METHODS: After establishing the TBI model in mice, we determined the biochemical and morphological changes associated with ferroptosis, including iron accumulation with Perl's staining, neuronal cell death with Fluoro-Jade B (FJB) staining, iron metabolism dysfunction with Western blotting, reactive oxygen species (ROS) accumulation with malondialdehyde (MDA) assays, and shrunken mitochondria with transmission electron microscopy...
September 28, 2018: CNS Neuroscience & Therapeutics
Andras Perl
No abstract text is available yet for this article.
September 24, 2018: EBioMedicine
Christine M McMahon, Alexander E Perl
Primary refractory acute myeloid leukemia (AML), or primary induction failure, represents a continued challenge in clinical management. This review presents an overview of primary refractory disease and a discussion of risk factors for induction failure, including current evidence regarding the impact of karyotype and molecular mutation status on responsiveness to chemotherapy. We review the evidence for various treatment options for refractory AML including salvage chemotherapy regimens, allogeneic hematopoietic stem cell transplantation, targeted agents, and non-intensive therapies such as hypomethylating agents...
September 20, 2018: Leukemia & Lymphoma
Shekher Mohan, Emily J Koller, Jawad A Fazal, Gabriela De Oliveria, Anna I Pawlowicz, Sylvain Doré
Background: The release of inflammatory molecules such as prostaglandins (e.g., PGF2α ) is associated with brain damage following an intracerebral hemorrhagic (ICH) stroke; however, the role of PGF2α and its cognate FP receptor in ICH remains unclear. This study focused on investigating the role of the FP receptor as a target for novel neuroprotective drugs in a preclinical model of ICH, aiming to investigate the contribution of the PGF2α -FP axis in modulating functional recovery and anatomical outcomes following ICH...
2018: Frontiers in Neuroscience
Clara Grilo, Michely R Coimbra, Rafaela C Cerqueira, Priscilla Barbosa, Rubem A P Dornas, Larissa O Gonçalves, Fernanda Z Teixeira, Igor Pfeifer Coelho, Brenda R Schmidt, Diana L K Pacheco, Gabriela Schuck, Isadora B Esperando, Juan A Anza, Júlia Beduschi, Nicole R Oliveira, Paula F Pinheiro, Alex Bager, Helio Secco, Marcello Guerreiro, Carine F Carvalho, Aline C Veloso, Ana E I Custódio, Oswaldo Marçal, Giordano Ciocheti, Julia Assis, Milton Cezar Ribeiro, Beatriz S S Francisco, Jorge J Cherem, Tatiane C Trigo, Márcia M A Jardim, Ingridi C Franceschi, Caroline Espinosa, Flávia P Tirelli, Vlamir J Rocha, Margareth L Sekiama, Gedimar P Barbosa, Helen R Rossi, Tainah C Moreira, Marcelo Cervini, Clarissa Alves Rosa, Lucas Gonçalves Silva, Claudia M M Ferreira, Augusto César, Janaina Casella, Sérgio L Mendes, Juliana Zina, Deivson F O Bastos, Ricardo A T Souza, Paulo A Hartmann, Angela C G Deffaci, Jéssica Mulinari, Siane C Luzzi, Tiago Rezzadori, Cassiane Kolcenti, Tiago Xavier Reis, Vanessa S C Fonseca, Camilo F Giorgi, Raissa P Migliorini, Carlos Benhur Kasper, Cecília Bueno, Marcela Sobanski, Ana P F G Pereira, Fernanda A G Andrade, Marcus E B Fernandes, Luiz L C Corrêa, Adriana Nepomuceno, Aureo Banhos, Wellington Hannibal, Rogério Fonseca, Lizit A Costa, Emilia P Medici, Aline Croce, Karin Werther, Juliana P Oliveira, Julia M Ribeiro, Mariele de Santi, Aline E Kawanami, Livia Perles, Caroline do Couto, Daniela S Figueiró, Eduardo Eizirik, Antonio A Correia, Fabio M Corrêa, Diego Queirolo, André L Quagliatto, Bruno H Saranholi, Pedro M Galetti, Karen G Rodriguez-Castro, Vivian S Braz, Frederico G R França, Gerson Buss, Josias A Rezini, Marília B Lion, Carolina C Cheida, Ana C R Lacerda, Carlos Henrique Freitas, Fernando Venâncio, Cristina H Adania, Augusto F Batisteli, Carla G Z Hegel, José A Mantovani, Flávio H G Rodrigues, Tathiana Bagatini, Nelson H A Curi, Luciano Emmert, Renato H Erdmann, Raoni R G F Costa, Agustín Martinelli, Clarice V F Santos, Andreas Kindel
Mortality from collision with vehicles is the most visible impact of road traffic on wildlife. Mortality due to roads (hereafter road-kill) can affect the dynamic of populations of many species and can, therefore, increase the risk of local decline or extinction. This is especially true in Brazil, where plans for road network upgrading and expansion overlaps biodiversity hotspot areas, which are of high importance for global conservation. Researchers, conservationists and road planners face the challenge to define a national strategy for road mitigation and wildlife conservation...
September 19, 2018: Ecology
Michal Laufer-Perl, Matthew Derakhshesh, Assi Milwidsky, Liat Mor, Dor Ravid, Nadav Amrami, Jack Sherez, Gad Keren, Yan Topilsky, Yaron Arbel
Cardiotoxicity from cancer therapy has become a leading cause of morbidity and mortality in cancer survivors. The most commonly used definition is cancer therapeutic related cardiac dysfunction defined as a left ventricular ejection fraction (LVEF) reduction of >10%, to a value below 50%. However, according to the recent American and European Society of Echocardiography, global longitudinal strain (GLS) is the optimal parameter for early detection of subclinical left ventricular dysfunction. The objective of this study was to evaluate the frequency of GLS reduction in patients with active cancer and its correlation to other echocardiographic parameters...
August 20, 2018: American Journal of Cardiology
Christian von Rüden, Lisa Wenzel, Johannes Becker, Andreas Thannheimer, Peter Augat, Alexander Woltmann, Volker Bühren, Mario Perl
INTRODUCTION: Aim of this retrospective analysis of prospectively collected data was to evaluate the functional mid-term outcome two years after open reduction and internal fixation of acetabular fractures involving the anterior column with affection of the quadrilateral plate using the pararectus approach on a large cohort. METHOD: Fifty-two patients (12 female, 40 male) with a median age of 55 (range 18-90) years and displaced acetabular fractures involving the anterior column were surgically treated in a single level I trauma centre between July 2012 and February 2016 using the pararectus approach...
September 14, 2018: International Orthopaedics
Marie-Paule Lefranc, François Ehrenmann, Sofia Kossida, Véronique Giudicelli, Patrice Duroux
IMGT® , the international ImMunoGeneTics information system® ( ), was created in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS) to manage the huge diversity of the antigen receptors, immunoglobulins (IG) or antibodies, and T cell receptors (TR). The founding of IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. Standardized sequence and structure analysis of antibody using IMGT® databases and tools allow one to bridge, for the first time, the gap between antibody sequences and three-dimensional (3D) structures...
2018: Methods in Molecular Biology
Barjinderjit Kaur Dhillon, Gunjan Chopra, Manu Jamwal, Giri Raj Chandak, Ajay Duseja, Pankaj Malhotra, Yogesh Kumar Chawla, Gurjeewan Garewal, Reena Das
Hereditary hemochromatosis (HH) is a rare disorder in Indians and is not associated with the common mutation Cys282Tyr in HFE gene found in Caucasians. Non-HFE HH can be associated with mutations in HJV, HAMP, TFR2 and SLC40A1 genes. Nineteen unrelated north Indian HH patients were detected after screening 258 chronic liver disease patients on the basis of increased transferrin saturation, ferritin levels >1000 ng/L and siderosis by Perl's stain on liver biopsy wherever available. Automated DNA sequencing was performed for the promoters and entire coding exons for HFE, HJV, HAMP, TFR2 and SLC40A1...
August 27, 2018: Blood Cells, Molecules & Diseases
Jason J Gokey, John Snowball, Anusha Sridharan, Joseph P Speth, Katharine E Black, Lida P Hariri, Anne-Karina T Perl, Yan Xu, Jeffrey A Whitsett
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease causing fibrotic remodeling of the peripheral lung, leading to respiratory failure. Peripheral pulmonary epithelial cells lose normal alveolar epithelial gene expression patterns and variably express genes associated with diverse conducting airway epithelial cells, including basal cells. Single-cell RNA sequencing of pulmonary epithelial cells isolated from IPF lung tissue demonstrated altered expression of LncRNAs, including increased MEG3...
September 6, 2018: JCI Insight
Graham M Hughes, Emma C Teeling
Summary: A number of limiting factors mean that traditional genome annotation tools either fail or perform sub-optimally when trying to detect coding sequences in poor quality genome assemblies/genome reports. This means that potentially useful data is accessible only to those with specific skills and expertise in assembly and annotation. We present an Assembled-Genome mInig pipeLinE (AGILE) written in Perl that combines bioinformatics tools with a number of steps to overcome the limitations imposed by such assemblies when applied to highly fragmented genomes...
September 4, 2018: Bioinformatics
Gregory W Schwartz, Bryan S Manning, Yeqiao Zhou, Priya D Velu, Ashkan Bigdeli, Rachel Astles, Anne W Lehman, Jennifer Jd Morrissette, Alexander E Perl, Mingyao Li, Martin Carroll, Robert Babak Faryabi
PURPOSE: Recurrent internal tandem duplication (ITD) mutations are observed in various cancers including acute myeloid leukemia (AML), where ITD mutations in tyrosine kinase receptor FLT3 are associated with poor prognostic outcomes. Several FLT3 inhibitors (FLT3i) are in clinical trials for high-risk FLT3 -ITD-positive AML. However, the variability of survival following FLT3i treatment suggests that the mere presence of FLT3 -ITD mutations might not guarantee effective clinical response...
September 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Richard M Hoglund, Ronnatrai Ruengweerayut, Kesara Na-Bangchang
BACKGROUND: Low mefloquine exposure has been shown to contribute to treatment failure in patients with uncomplicated falciparum malaria following a 3-day artesunate-mefloquine combination. The present study aimed to develop a population pharmacokinetic model for mefloquine based on whole blood concentration-time profiles of this target population for further dose optimization. METHODS: A total of 129 Burmese patients aged above 15 years who presented with typical symptoms of malaria and had a blood smear positive for Plasmodium falciparum were included in the study...
September 3, 2018: Malaria Journal
Jinxia Wu, Lei Yang, Xiaofeng Zhang, Yang Li, Jianyao Wang, Shenshen Zhang, Haohao Liu, Hui Huang, Yueqin Wang, Le Yuan, Xuemin Cheng, Donggang Zhuang, Huizhen Zhang, Xinghai Chen
The liver is an important iron storage site and a primary MC-LR target. C57BL/6 and Hfe-/- mice were used to investigate effects and mechanisms of MC-LR on systematic iron homeostasis. Body weight, tissue iron content, hematological and serological indexes, and histopathological were evaluated. Ultrastructure and iron metabolism-related genes and proteins were analyzed. MC-LR induced dose-dependent increases in red blood cells, hemoglobin, and hematocrit. In contrast MC-LR-induced dose-dependent decreases in mean corpuscular volume, hemoglobin, and hemoglobin concentration were observed both C57BL/6 and Hfe-/- mice...
December 2018: Chemosphere
Ana M Rule, Otis Apau, Steven H Ahrenholz, Scott E Brueck, William G Lindsley, Marie A de Perio, John D Noti, Ronald E Shaffer, Richard Rothman, Alina Grigorovitch, Bahar Noorbakhsh, Donald H Beezhold, Patrick L Yorio, Trish M Perl, Edward M Fisher
INTRODUCTION: Healthcare personnel are at high risk for exposure to influenza by direct and indirect contact, droplets and aerosols, and by aerosol generating procedures. Information on air and surface influenza contamination is needed to assist in developing guidance for proper prevention and control strategies. To understand the vulnerabilities of healthcare personnel, we measured influenza in the breathing zone of healthcare personnel, in air and on surfaces within a healthcare setting, and on filtering facepiece respirators worn by healthcare personnel when conducting patient care...
2018: PloS One
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