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Filipe Martins Santos, Gabriel Carvalho de Macedo, Wanessa Teixeira Gomes Barreto, Luiz Gustavo Rodrigues Oliveira-Santos, Carolina Martins Garcia, Guilherme de Miranda Mourão, Grasiela Edith de Oliveira Porfírio, Elizangela Domenis Marino, Marcos Rogério André, Lívia Perles, Carina Elisei de Oliveira, Gisele Braziliano de Andrade, Ana Maria Jansen, Heitor Miraglia Herrera
The occurrence of Trypanosoma spp. in wild carnivore populations has been intensively investigated during the last decades. However, the impact of these parasites on the health of free-living infected animals has been largely neglected. The Pantanal biome is the world's largest seasonal wetland, harboring a great diversity of species and habitats. This includes 174 species of mammals, of which 20 belong to the order Carnivora. The present study aimed to investigate the effect of Trypanosoma evansi and Trypanosoma cruzi infections and coinfections on the health of the most abundant carnivores in the Pantanal: coati (Nasua nasua), crab-eating fox (Cerdocyon thous), and ocelot (Leopardus pardalis)...
2018: PloS One
Zach Rozenbaum, Yan Topilsky, Shafik Khoury, David Pereg, Michal Laufer-Perl
BACKGROUND: Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction. METHODS AND RESULTS: Echocardiograms of metabolically healthy patients between 2011 and 2016, who had no significant valvulopathies or atrial fibrillation, and had preserved ejection fraction, were retrospectively identified and analyzed...
August 4, 2018: International Journal of Cardiology
Yanfei Guan, Victoria M Ingman, Benjamin J Rooks, Steven E Wheeler
We describe an open-source computational toolkit (AARON: An Automated Reaction Optimizer for New catalysts) that automates the quantum mechanical geometry optimization and characterization of the transition state and intermediate structures required to predict the activities and selectivities of asymmetric catalytic reactions. Modern computational quantum chemistry has emerged as a powerful tool for explaining the selectivity and activity of asymmetric catalysts. However, reliably predicting the stereochemical outcome of realistic reactions often requires the geometry optimization of hundreds of transition state and intermediate structures, which is a tedious process...
August 10, 2018: Journal of Chemical Theory and Computation
George M Weisz, Konrad Kwiet
Despite daunting circumstances, history is full of stories of men and women incarcerated by the Nazis, who risked their lives to save others. In some cases, the moral dilemma faced by these people presented an unquestionable challenge-particularly for those in the medical profession who had taken an oath to save life. This paper presents the dramatic stories of Dr. Gisella Perl and Dr. Erno Vadasz. Although their choices were markedly different, their goals were the same-to save as many lives as possible.
July 30, 2018: Rambam Maimonides Medical Journal
Aimee Louise McNamara, Jose Ramos-Mendez, Joseph Perl, Kathryn Held, Naoki Dominguez, Eduardo Barbosa Moreno, Nicholas T Henthorn, Karen J Kirkby, Sylvain Meylan, Carmen Villagrasa, Sebastien Incerti, Bruce Faddegon, Harald Paganetti, Jan Schuemann
Computational simulations, such as Monte Carlo track structure simulations, offer a powerful tool for quantitatively investigating radiation interactions within cells. The modelling of the spatial distribution of energy deposition events as well as diffusion of chemical free radical species, within realistic biological geometries, can help provide a comprehensive understanding of the effects of radiation on cells. Track structure simulations, however, generally require advanced computing skills to implement...
August 8, 2018: Physics in Medicine and Biology
Ángela Valentín-Pérez, Josefina Perles, Santiago Herrero, Reyes Jiménez-Aparicio
[Ru2 Cl2 (DPhF)3 ] (DPhF = diphenylformamidinate) links preferentially to the junctions of RNA (ribonucleic acid) structures, although the bonding mode is not known. In order to clarify this question the reactions between [Ru2 Cl2 (DPhF)3 ] and cytosine (Hcyto), cytidine (Hcyti), cytidine 2',3'-cyclic monophosphate sodium salt (NacCMP), adenine (Hade), adenosine (Haden) and adenosine 3',5'-cyclic monophosphate (HcAMP) have been carried out. In the resultant complexes, cyto (cytosinate), cyti (cytidinate), cCMP (cytidine 2',3'-cyclic monophosphate monoanion), ade (adeninate), aden (adenosinate) and cAMP (deprotonated adenosine 3',5'-cyclic monophosphate) are bonded to the diruthenium unit as N,N'-bridging ligands, as confirmed by the solution of the crystal structures of [RuCl(DPhF)3 (cyto)] and [RuCl(DPhF)3 (ade)] by X-ray diffraction...
June 30, 2018: Journal of Inorganic Biochemistry
Anna Tessari, Kareesma Parbhoo, Meghan Pawlikowski, Matteo Fassan, Eliana Rulli, Claudia Foray, Alessandra Fabbri, Valerio Embrione, Monica Ganzinelli, Marina Capece, Moray J Campbell, Massimo Broggini, Krista La Perle, Gabriella Farina, Sara Cole, Mirko Marabese, Marianna Hernandez, Joseph M Amann, Giancarlo Pruneri, David P Carbone, Marina C Garassino, Carlo M Croce, Dario Palmieri, Vincenzo Coppola
Although limited by severe side effects and development of resistance, platinum-based therapies still represent the most common first-line treatment for non-small cell lung cancer (NSCLC). However, a crucial need in the clinical management of NSCLC is represented by the identification of cases sensitive to DNA damage response (DDR)-targeting drugs, such as cisplatin or PARP inhibitors. Here, we provide a molecular rationale for the stratification of NSCLC patients potentially benefitting from platinum compounds based on the expression levels of RANBP9, a recently identified player of the cellular DDR...
August 3, 2018: Oncogene
A Elbahi, A Kipar, L Ressel
This report describes a series of four equine mast cell tumours (MCTs) with atypical morphological features. The tumours were 1-2 cm in diameter and mostly localized to the eyes (one eyelid, two conjunctiva). Histologically, they were composed of very large (up to 35 μm) round pleomorphic cells with a large central to paracentral nucleus and abundant granular cytoplasm. A large number of viable mature eosinophils were detected intermingled with the large round cells. Histochemical staining (toluidine blue and Perls' Prussian blue) and immunohistochemistry (KIT, mast cell tryptase, lysozyme and proliferating cell nuclear antigen) confirmed the mast cell origin of the atypical cells and identified an aberrant KIT protein expression in three cases...
July 2018: Journal of Comparative Pathology
Paola Sebastiani, Anastasia Gurinovich, Marianne Nygaard, Takashi Sasaki, Benjamin Sweigart, Harold Bae, Stacy L Andersen, Francesco Villa, Gil Atzmon, Kaare Christensen, Yasumichi Arai, Nir Barzilai, Annibale Puca, Lene Christiansen, Nobuyoshi Hirose, Thomas T Perls
We assembled a collection of 28,297 participants from 7 studies of longevity and healthy aging comprising New England Centenarian, Long Life Family, Longevity Gene Population, Southern Italian Centenarian, Japanese Centenarian, the Danish Longevity and the Health and Retirement Studies to investigate the association between the APOE alleles ɛ2, ɛ3 and ɛ4 and extreme human longevity and age at death. By using 3 different genetic models and two definitions of extreme longevity based on either a threshold model or age at death, we show that ɛ4 is associated with a substantially decreased odds for extreme longevity, and increased risk for death that persists even beyond ages reached by less than 1% of the population...
July 27, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Yula Shnaider, Deblina Mitra, Golan Miller, Avital Baniel, Tirza Doniger, Anastasiya Kuhalskaya, Federico Scossa, Alisdair R Fernie, Yariv Brotman, Rafael Perl-Treves
Cucurbits represent an attractive model to explore the dynamics of fruit set, whose regulation is not fully understood, despite its importance for yield determination. A fertilized ovary must integrate signals from distant plant parts and "decide" whether to set fruit, or remain inhibited, and later senesce. Here we set out to characterize first fruit inhibition (FFI), i.e. the inhibitory effect of the first fruit on subsequent development of younger ovaries during pollination-induced and parthenocarpic fruit set...
July 30, 2018: Plant Journal: for Cell and Molecular Biology
Neil Boudville, David W Johnson, Junhui Zhao, Brian A Bieber, Ronald L Pisoni, Beth Piraino, Judith Bernardini, Sharon J Nessim, Yasuhiko Ito, Graham Woodrow, Fiona Brown, John Collins, Talerngsak Kanjanabuch, Cheuk-Chun Szeto, Jeffrey Perl
Background: Peritoneal dialysis (PD)-related infections lead to significant morbidity. The International Society for Peritoneal Dialysis (ISPD) guidelines for the prevention and treatment of PD-related infections are based on variable evidence. We describe practice patterns across facilities participating in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS). Methods: PDOPPS, a prospective cohort study, enrolled nationally representative samples of PD patients in Australia/New Zealand (ANZ), Canada, Thailand, Japan, the UK and the USA...
July 23, 2018: Nephrology, Dialysis, Transplantation
Chitra S Nayak, Atul S Giri, Uddhao S Zambare
Context: "Dark circles" are esthetic concerns that can affect individuals of any age, gender, or race. They can be familial, physiological, or associated with various medical illnesses. Aim: To study the clinicopathological correlation of periorbital hyperpigmentation. Patients and Methods: Fifty patients affected with periorbital melanosis (POM) were enrolled for the study after obtaining informed consent. Details regarding history, demographic data, and physical examination of POM were recorded, and a 2-mm punch skin biopsy was taken from the affected skin under local anesthesia and stained with hematoxylin and eosin (H and E), Fontana Masson (Melanin), Perls Prussian blue (Hemosiderin)...
July 2018: Indian Dermatology Online Journal
Evelyn Guirado, Murugesan Vs Rajaram, Ajay Chawla, Joanna Daigle, Krista Md La Perle, Eusondia Arnett, Joanne Turner, Larry S Schlesinger
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear transcription factor belonging to the superfamily of ligand-activated nuclear receptors. It is activated by diverse endogenous lipid metabolites as well as by exogenous ligands such as the thiazolidinediones. It regulates cellular metabolism, proliferation, differentiation, and inflammation, the latter in part through trans-repression of pro-inflammatory cytokines. PPARγ is highly expressed in alternatively activated alveolar macrophages (AMs), a primary host cell for airborne Mycobacterium tuberculosis (M...
July 2018: Tuberculosis
Craig D Perl, Jeremy E Niven
Metabolic rate and its relationship with body size is a fundamental determinant of many life history traits and potentially of organismal fitness. Alongside various environmental and physiological factors, the metabolic rate of insects is linked to distinct ventilation patterns. Despite significant attention, however, the precise role of these ventilation patterns remains uncertain. Here we determine the allometric scaling of metabolic rate and respiratory water loss in the red wood ant, as well as assessing the effect of movement upon metabolic rate and ventilation pattern...
July 19, 2018: Journal of Experimental Biology
Scott Brian Minchenberg, Geeta Chaparala, Zachary Oaks, Katalin Banki, Andras Perl
In this study, we investigated four patients who met the diagnostic criteria for overlapping systemic lupus erythematosus (SLE) and myasthenia gravis (MG) but responded differently to treatment. All patients were acetylcholine receptor (AChR) and antinuclear antibody positive at the time of SLE diagnosis. Two patients presented with SLE who have been effectively treated with cholinesterase inhibitors for MG. These patients developed SLE with photosensitivity, rash, and arthritis post thymectomy, which had been performed 29 years and 40 years earlier, respectively...
July 17, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Rocco Servidio, Michael Cronin
The implementation of innovative eLearning platforms offers numerous benefits, but it is important to understand individual acceptance and use of new technological systems in the educational setting. This study adopts a modified version of the Technology Acceptance Model (TAM), including three service quality constructs as external variables, to assess students' acceptance of PerLE, a Moodle-based eLearning platform developed at the University of Calabria (Italy). A six-section questionnaire, which was based on previous studies, was administered to 293 undergraduate students...
July 16, 2018: Behavioral Sciences
André Gohr, Manuel Irimia
Summary: Tracking thousands of alternative splicing (AS) events genome-wide makes their downstream analysis computationally challenging and laborious. Here, we present Matt, the first UNIX command-line toolkit with focus on high-level AS analyses. With 50 commands it facilitates computational AS analyses by i) expediting repetitive data-preparation tasks, ii) offering routine high-level analyses, including the extraction of exon/intron features, discriminative feature detection, motif enrichment analysis, and the generation of motif RNA-maps, iii) improving reproducibility by documenting all analysis steps, and iv) accelerating the implementation of own analysis pipelines by offering users to exploit its modular functionality...
July 13, 2018: Bioinformatics
Sabrina Elisa Oliveira, Pauliane Melo Costa, Sara Batista Nascimento, Whocely Victor Castro, Rosy Iara Maciel de Azambuja Ribeiro, Hélio Batista Santos, Ralph Gruppi Thomé
Atrazine is a herbicide that is banned in Europe but remains widely used on different types of crops in several countries in the American continent. Atrazine is known to be an endocrine disruptor and its effects on gonads have been extensively reported, but the toxic action on other organs is poorly documented. In this paper, we investigated the toxicity of atrazine on the gills and spleens of Nile tilapia (Oreochromis niloticus). The median lethal concentration (LC50 ), capable of killing one-half of the test animals was calculated, and sublethal concentrations of atrazine were used in a semistatic and subchronic assay...
September 2018: Aquatic Toxicology
Li Niu, Cuifang Ye, Yun Sun, Ting Peng, Shiming Yang, Weixi Wang, He Li
Background: Iron accumulation in basal ganglia accompanies neuronal loss in Huntington's disease (HD) patients and mouse disease models. Disruption of HD brain iron homeostasis occurs before the onset of clinical signs. Therefore, investigating the mechanism of iron accumulation is essential to understanding its role in disease pathogenesis. Methods: N171-82Q HD transgenic mice brain iron was detected by using Diaminobenzidine-enhanced Perls' stain. Iron homeostatic proteins including iron response protein 1 (IRP1), transferrin (Tf), ferritin and transferrin receptor (TfR) were determined by using western blotting and immunohistochemistry, and their relative expression levels of RNA were measured by RT-PCR in both N171-82Q HD transgenic mice and HEK293 cells expressing N-terminal of huntingtin...
2018: Cell & Bioscience
Samer Omari, Yuri Kamenir, Jennifer I C Benichou, Sarah Pariente, Hanan Sela, Rafael Perl-Treves
Following publication of the original article [1], the authors reported the need for a more detailed acknowledgement of the source of the samples that were analyzed and their coordinates, which are discussed in the 'Methods' section of the article. This Correction provides an addition to the 'Methods' section, and a subsequently revised 'Acknowledgements' and 'Availability of data and materials' section.
July 12, 2018: BMC Genetics
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