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İrfan Özyazgan, Yalcin Yontar, Ercan M Aygen, Ahmet Aydin
AIM: The aims of this study were to present the results of using infragluteal folds as a skin graft donor site in cases of Mullerian agenesis undergoing full-thickness skin graft vaginoplasty and to evaluate the outcomes of the surgical technique. METHODS: Demographics and clinical parameters of 24 consecutive Mullerian agenesis patients refusing any dilatational procedure and undergoing neovaginal construction using infragluteal folds skin grafts from May 2004 to July 2015 were analyzed...
August 16, 2018: Journal of Obstetrics and Gynaecology Research
Myrto Korogiannaki, Michael Samsom, Tannin A Schmidt, Heather Sheardown
Ocular dryness and discomfort is the primary reason for the discontinuation of contact lens wear. This is mainly due to poorly hydrated contact lens surfaces and increased friction, particularly at the end of the day and can potentially cause reduced vision or even inflammation. Proteoglycan 4 (PRG4) is a mucinous glycoprotein with boundary lubricating properties, naturally found in the eye, able to prevent tear film evaporation and protect the ocular surface during blinking. Aiming to improve the interfacial interactions between the ocular surface and the contact lens, the synthesis and characterization of surface modified model contact lenses with PRG4 is described...
August 16, 2018: ACS Applied Materials & Interfaces
Kelly K Nichols, Eric D Donnenfeld, Paul M Karpecki, John A Hovanesian, Aparna Raychaudhuri, Amir Shojaei, Steven Zhang
PURPOSE: Characterize the safety and tolerability of lifitegrast ophthalmic solution 5.0% for the treatment of dry eye disease. METHODS: Pooled data from five randomized controlled trials were analyzed. Key inclusion criteria were adults with dry eye disease (Schirmer tear test score ⩾1 and ⩽10 mm, eye dryness score ⩾40 (visual analog scale 0-100), corneal staining score ⩾2.0 (0-4 scale)). Participants were randomized to lifitegrast ophthalmic solution 5...
August 16, 2018: European Journal of Ophthalmology
Xiaozhi Xi, Jia Li, Shasha Guo, Yujuan Li, Fangxue Xu, Mengmeng Zheng, Hui Cao, Xiaowei Cui, Hong Guo, Chunchao Han
During ancient times in China, bee pollen was used for skin whitening and beauty. Around 70% of substances in bee pollen are biologically active, such as proteins, carbohydrates, lipids and fatty acids, phenolic compounds, vitamins and bioelements.This review describes the cosmeceutical properties of bee pollen and the mechanism of its active components action, its beneficial influence on human skin. As a natural bee product, bee pollen may effectively enhance protective mechanisms against skin aging, skin dryness, ultraviolet B radiation, oxidative damage, inflammatory and melanogenesis, which are involved in a wide range of negative effects on human skin, thus they have attracted attention for health and cosmetic applications...
August 14, 2018: Journal of Oleo Science
Ling-Hang Qu, Ji-Yuan Tu, Guo-Sheng Cao, Jia-Wen Zhao, Xu-Ling Pan, Yan-Ju Liu
In order to establish a more perfect evaluation system for dryness effect of Atractylodis Rhizoma, determine the main dry parts of Atractylodis Rhizoma,and further define the mechanism of stir-baked Atractylodis Rhizoma in reducing the dryness. The healthy rats were given with different doses of water extract and volatile oil of raw Atractylodis Rhizoma and stir-baked Atractylodis Rhizoma for 21 days. Based on the theory of the dry-dry and dryness-induced Yin deficiency, the amount of drinking water, tissue morphology of submandibular glands, urine volume and the expression of aquaporin 2 (AQP2) in the kidneys, as well as blood rheology, ratio of cAMP/cGMP in serum and the content of Na⁺-K⁺-ATP enzyme were selected as the evaluation indexes...
July 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Gao Zhen, Wang Jing, Jing Jing, Dan Xu, Li Zheng, Fengsen Li
Objective. In China, the Chinese medicine formula modified zhisou powder (MZP) is commonly used to treat COPD with cold-dryness syndrome (CDSCOPD) to relieve cough and sputum. However, the underlying mechanisms of MZP on treating CDSCOPD remain to be elucidated. Methods . COPD and CDSCOPD rat models were established; MZP was given to CDSCOPD rats in the last 7 days of the 97-day model establishment. Then the rats were subjected to lung function measurement. Pathological changes in lungs were observed through paraffin section and H&E staining...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Iuliia Naumova, Camil Castelo-Branco
Vulvovaginal atrophy (VVA) is a silent epidemic that affects up to 50%-60% of postmenopausal women who are suffering in silence from this condition. Hormonal changes, especially hypoestrogenism inherent in menopause, are characterized by a variety of symptoms. More than half of menopausal women are concerned about the symptoms of VVA, such as dryness, burning, itching, vaginal discomfort, pain and burning when urinating, dyspareunia, and spotting during intercourse. All these manifestations significantly reduce the quality of life and cause discomfort in the sexual sphere...
2018: International Journal of Women's Health
Eleni Pitsouni, Themos Grigoriadis, Athanasios Douskos, Margarita Kyriakidou, Matthew E Falagas, Stavros Athanasiou
Genitourinary syndrome of menopause (GSM) increases the probability of female sexual dysfunction (FSD). The aim of the current study is to systematically assess data regarding sexual function and use of vaginal therapies, alternative to vaginal estrogens (VE), in menopausal women with GSM. PubMed, Scopus and Cochrane Library were searched (May-September 2017) using combination keywords: "dyspareunia and vaginal therapy", "sexual function and vaginal therapy", "orgasm and vaginal therapy", "vaginal atrophy" and "genitourinary syndrome of menopause"...
August 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Kiri A Sandler, Sandra A Mitchell, Ethan Basch, Ann C Raldow, Michael L Steinberg, Jamal Sharif, Ryan R Cook, Patrick A Kupelian, Susan A McCloskey
PURPOSE: To improve assessment of symptomatic toxicity in cancer clinical trials and complement clinician-based toxicity reporting, the US National Cancer Institute developed a measurement system called the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). The objective of this study was to examine the content validity of PRO-CTCAE in patients undergoing radiation therapy and to establish anatomic site-specific item sets for implementation in cancer research...
September 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Abdulmecit Yavuz, Goksel Bayar, Muhammet Fatih Kilinc, Umut Sariogullari
OBJECTIVES: To compare the frequency of spina bifida occulta (SBO) detected in patients with nocturnal enuresis (NE) and to investigate its clinical significance. METHODS: Patients aged 6 to 15 years who were admitted to the urology clinic with NE were included in this prospective study. The control group consisted of patients who were admitted with a complaint of abdominal or lateral pain. The patients who had lower urinary tract symptoms (LUTS) were classified as nonmonosymptomatic NE (NMNE)...
August 9, 2018: Urology
Harumitsu Hirata, Valentina Dallacasagrande, Kamila Mizerska, Evguenia Ivakhnitskaia, Mark I Rosenblatt
Purpose: Previously we found two types of corneal neurons that we hypothesized to play an important role in tearing. One type is called low threshold-cold sensitive plus dry sensitive (LT-CS + DS), and the other is termed high threshold-cold sensitive plus dry sensitive (HT-CS + DS). The present study examined critical stimuli influencing the activity of these neurons to elucidate environmental factors that may trigger this ocular reflex. Methods: Single corneal neurons were extracellularly recorded from the trigeminal ganglia in response to ocular stimuli that mimic environmental conditions one encounters in daily life...
August 1, 2018: Investigative Ophthalmology & Visual Science
Ivan Yeu Ming Yip, Akash Raj
Purpose: Latanoprost is known to have several ocular side effects, including redness of the eyelids, lengthening of the eyelashes, an increase in iris pigmentation, and dryness of the eyes that causes discomfort. There are also several rarer systemic side effects reported in the literature, including chest pain. Case Report: Here we report a rare case of a patient who developed a cutaneous blistering rash on both eyelids, both sides of the neck, and the dorsum of both hands after direct contact with latanoprost eye drops...
July 2018: Journal of Ophthalmic & Vision Research
Ivan Ignjatovic, Dragoslav Basic, Milan Potic, Ljubomir Dinic, Aleksandar Skakic
INTRODUCTION: Distal urogenital fistulas (DUF) are usually iatrogenic and are uncommon in Europe. They occur in the urethra or near the bladder neck, and can be caused by vaginal hysterectomy, para-urethral cyst surgery, or erosion of the bladder or urethra from tension-free slings or meshes. The psychological and physical health consequences of DUF are devastating because most patients consider themselves "healthy" before surgery. Incontinence can appear after successful DUF closure due to previously occult incontinence or urethral incompetence...
August 1, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Jae-Woo Kwon, Hee-Won Park, Woo Jin Kim, Man-Goo Kim, Seung-Joon Lee
BACKGROUND: Exposure to low levels of volatile organic compounds (VOCs) in ordinary life is suspected to be related to oxidative stress and decreased lung function. This study evaluated whether exposure to ambient VOCs in indoor air affects airway inflammation. METHODS: Thirty-four subjects from the hospital that had moved to a new building were enrolled. Symptoms of sick building syndrome, pulmonary function tests, and fractional exhaled nitric oxide (FeNO) were evaluated, and random urine samples were collected 1 week before and after the move...
August 7, 2018: Environmental Health: a Global Access Science Source
Katsura Mori, Tsuyoshi Seki, Kazuhiro Kaizu, Yutaka Takagi, Masahiro Miyaki, Chiaki Ishizaki, Ichiro Katayama
BACKGROUND: Skin moisturizing is advocated to take care of the skin of patients with atopic dermatitis (AD). However, many patients stop using moisturizers in the summer because of excessive sweating and high humidity. OBJECTIVES: To examine the efficacy of a moisturizing gel containing a pseudo-ceramide and a eucalyptus extract, which enhances epidermal ceramide synthesis of patients with mild AD in the summer. METHODS: We performed a single-blinded 4-week clinical trial of body care on 44 Japanese subjects who had mild AD...
August 6, 2018: Journal of Cosmetic Dermatology
Farooq Ahmad, Tanveer Ahmad, Muhammad Umair, Abdullah, Wasim Ahmad
Hypohidrotic Ectodermal Dysplasia (HED) is a classic triad encompasses deformities of hair (hypotrichosis), teeth (anodontia/hypodontia), and/or sweat glands (anhidrosis/hypohidrosis). Associated clinical hallmarks include hyperthermia, dryness of skin, eyes, airways, and mucous membranes, prominent forehead, prominent lips, dark, hyperkeratinized skin around the eyes and everted nose (Clarke, 1987). This article is protected by copyright. All rights reserved.
August 5, 2018: Congenital Anomalies
Danlu Cai, Klaus Fraedrich, Yanning Guan, Shan Guo, Chunyan Zhang, Xiuhua Zhu
To quantify how urbanization induced long-term changes have altered the evolution of urban climate, a novel eco-hydrological diagnostic is introduced and applied globally, to a developing and a developed country (China and US-America). Urban areas are (i) geographically identified by remote sensing based nighttime light, (ii) physically embedded in state spaces spanned by suitable combinations of surface energy and water fluxes comprising the rainfall-runoff chain, and (iii) dynamically characterized by the time evolution of the surface fluxes at geographically fixed locations, analyzed as trajectories in state space, and interpreted by an attribution model separating anthropogenic from climate induced causes...
July 23, 2018: Science of the Total Environment
Suo Decheng, Wang Peilong, Li Yang, Wang Ruiguo, Wei Shulin, Xiao Zhiming, Zhang Su
In this study, a method for simultaneous determination of 40 antibiotics from 6 different drug families (7 quinolones, 5 penicillins, 8 macrolides, 2 lincosamides, 4 tetracyclines, and 13 sulfonamides) and 3 amantadines in animal-derived feedstuffs (ADF) through ultraperformance liquid chromatography-tandem mass spectrometry using a new lipid-removing solid-phase extraction column PRiME HLB was developed. The sample was extracted with 20 mL extraction solution and then purified and concentrated with PRiME HLB...
July 21, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ahmed Mahmoud Abdou, Islam Mohamed Magdi Ammar, Amr Abd Almohsen Alnemr, Amr Ahmed Abdelrhman
Objective: To compare the efficacy and safety of dienogest (DNG) with depot leuprolide acetate (LA) in patients with recurrent pelvic pain following laparoscopic surgery for endometriosis. Design: Prospective randomized trial. Setting: Zagazig University hospitals, Egypt. Patients: Two hundred and forty-two patients with recurrent pelvic pain following laparoscopic surgery for endometriosis. Intervention: Dienogest (2 mg/day, orally) or depot LA (3...
August 2018: Journal of Obstetrics and Gynaecology of India
Angelica C Scanzera, Ellen Shorter
SIGNIFICANCE: Familial dysautonomia is a rare genetic disorder that affects the sensory and autonomic nervous systems. Affected individuals have decreased corneal sensation and can develop serious complications from neurotrophic keratitis. Scleral devices are an excellent option for the long-term management of patients with familial dysautonomia and neurotrophic keratitis. PURPOSE: In this series, we describe three patients with familial dysautonomia and classic ocular complications fit with scleral devices...
August 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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