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Jennifer Barsky Reese, Kristen Sorice, Stephen J Lepore, Mary B Daly, James A Tulsky, Mary Catherine Beach
OBJECTIVES: Breast cancer patients' sexual health needs are frequently unmet. We examined the prevalence and content of communication about sexual health between breast cancer patients and clinicians. METHODS: Female breast cancer patients being seen in oncology clinic follow-up had a clinic visit audio recorded and self-reported sexual problems after the visit. Transcripts were coded for sexual health communication; data were analyzed descriptively or using Chi-square tests...
October 4, 2018: Patient Education and Counseling
Katarzyna Skośkiewicz-Malinowska, Barbara Malicka, Marek Ziętek, Urszula Kaczmarek
Depression is a common disorder among the elderly; however, it is not a standard element of the ageing process. Depression can affect oral health as a result of neglecting oral hygiene procedures, cariogenic nutrition, avoidance of necessary dental care which leads to an increased risk of dental caries and periodontal disease.Assessment of the relationship of oral health parameters with depression.500 subjects aged ≥65 (mean 74.4 ± 7.4) were involved in the study. Dental condition (decay-missing-filled index [DMFT], number of missing teeth [MT], removable denture wearing, teeth mobility), periodontal condition (bleeding on probing [BoP], pocket depth [PD], loss of attachment), oral dryness (the Challacombe Scale) and depression according to the Patient Health Questionnaire-9 (PHQ-9) scale were assessed...
October 2018: Medicine (Baltimore)
Nicco Krezdorn, Christine G Lian, Michael Wells, Luccie Wo, Sotirios Tasigiorgos, Shuyen Xu, Thiago J Borges, Rayven M Frierson, Ewelina Stanek, Leonardo V Riella, Bohdan Pomahac, George F Murphy
Face vascularized composite allografts (FVCA) have helped severe patient disfigurement, with acute rejection now largely controlled through iatrogenic immunosuppression. However, little is known regarding the incidence and mechanism(s) of more long-term pathologic alterations in FVCAs that may affect function and graft durability. Protocol surveillance biopsies for up to an 8 year interval in seven patients who received FVCAs at our institution revealed histopathologic evidence of chronic rejection. Clinical manifestations included features of premature aging, mottled leukoderma accentuating suture lines, telangiectasia, and dryness of nasal mucosa...
October 12, 2018: American Journal of Transplantation
Lara A Aqrawi, Xiangjun Chen, Janicke Liaaen Jensen, Mathias Kaurstad Morthen, Bernd Thiede, Øygunn Aass Utheim, Øyvind Palm, Behzod Tashbayev, Tor Paaske Utheim, Hilde Kanli Galtung
Ocular dryness is a characteristic feature of primary Sjögren's syndrome (pSS). This may result in dry eye disease (DED), leading to damage of the ocular surface. Additional, non-invasive diagnostic techniques are needed when evaluating pSS patients. Hence, screening for disease-specific biomarkers in biological fluid could be promising. We have previously examined the proteome of tear fluid from pSS patients through Liquid chromatography-mass spectrometry (LC-MS), and conducted a thorough ocular evaluation of patients with pSS...
2018: PloS One
Luz Arelis Moreno-Quispe, Ibis Veronica Nieves Velarde-Grados, Magna Guzmán-Avalos, Lorenzo De Arriba, Rosa Maria López-Pintor
OBJECTIVES: Sjögren's syndrome is a complex and heterogeneous autoimmune disease characterised by ocular and oral dryness (1), which mainly affects the exocrine glands. The objective of this study was to determine the prevalence of sicca syndrome (SS) in the Peruvian population. The age and gender of patients with SS and their national prevalence and in each of the departments were defined. METHODS: Cross-sectional prevalence study. All the people that the Ministry of Health (MINSA) in Peru covered health treatments from January to December 2016 were taken into account...
September 20, 2018: Clinical and Experimental Rheumatology
Nidhi Gupta, Manju Aggarwal, Renuka Sinha, Neha Varun
Objective: The objective of this study was (1) to find the prevalence of urogenital (UG) complaints after menopause, (2) to evaluate the various risk factors for UG problems in postmenopausal women, and (3) to assess the severity of the symptoms depending on the duration of menopause. Materials and Methods: This study is a prospective study conducted at the Specialty Outpatient Department in Safdarjung Hospital over a period of 1 year. Two hundred postmenopausal women during this period were screened for UG complaints by eliciting detailed history in a pro forma and were divided into two groups based on the duration of menopause...
July 2018: Journal of Mid-life Health
Raoul Vyumvuhore, Rime Michael-Jubeli, Laurie Verzeaux, David Boudier, Maud Le Guillou, Sylvie Bordes, Danielle Libong, Ali Tfayli, Michel Manfait, Brigitte Closs
OBJECTIVE: Although xerosis is a common skin disorder among the population, there is no in vivo global study focusing on xerotic skin. Hence, the objective of this study was to characterize xerotic skin from the surface to the molecular scale with in vivo and non-invasive approaches. METHODS: For this purpose, 15 healthy volunteers with normal skin and 19 healthy volunteers with xerotic skin were selected by a dermatologist thanks to a visual scorage. Firstly, the skin surface was characterized with biometric measurements...
October 4, 2018: International Journal of Cosmetic Science
Xia Liu, Xiaomei Li, Xiangpei Li, Zhijun Li, Dongbao Zhao, Shengyun Liu, Miaojia Zhang, Fengxiao Zhang, Ping Zhu, Jinwei Chen, Wei Wei, Bing Lin, Yingbo Zhou, Jing Chen, Yafei Pang, Lei Zhang, Xiaoxuan Sun, Zhibo Yu, Yun Jia, Jia Wang, Wenwen Sun, Frank Chiu, Liping Pang, Guochun Wang
To evaluate the efficacy and safety of total glucosides of peony (TGP) in adults with primary Sjögren's syndrome (pSS). A multi-center, randomized, double-blinded, placebo-controlled study was conducted between March 2012 and July 2014 at ten Chinese hospitals. In total, 320 pSS patients-classified according to the 2002 American-European Consensus Group Criteria-were randomized (2:1 ratio) to receive TGP(600 mg, tid) in the TGP group or placebo for 24 weeks in the placebo group. Study personnel, investigators, and patients were blinded to the treatment grouping...
October 2, 2018: Clinical Rheumatology
Hongbo Ling, Bin Guo, Guangpeng Zhang, Hailiang Xu, Xiaoya Deng
It is very important to construct a reasonable and efficient basin management system to meet the ecological water demand in arid areas with natural vegetation, and to maintain the integrity and stability of fragile ecosystems. However, how to assess the effect of basin management on ecological protection in arid areas as well as how to achieve the optimal control and efficient use of ecological water are major issues for many researchers and river basin managers. To address these two questions, we investigated the comprehensive management system for the Tarim River basin in China as a typical case study...
September 26, 2018: Science of the Total Environment
Diana Lüftner, Veronica Dell'Acqua, Frédéric Selle, Ahmed Khalil, Maria Cristina Leonardi, Alejandro De La Torre Tomás, George Shenouda, Jesus Romero Fernandez, Roberto Orecchia, Dominique Moyal, Sophie Seité
Introduction: The purpose of this multicenter, prospective, observational, open-label study was to evaluate the use and tolerability of dermo-cosmetic products in preventing skin reactions associated with cancer treatments. Patients and methods: A 12-product kit was supplied to patients before chemotherapy began and was to be used throughout the treatment phase. Cutaneous adverse events were evaluated at each treatment session. Physicians evaluated skin reactions (edema, erythema, dryness, desquamation, pigmentation disorders, and cracks) and gave their opinion on the skin benefit for patients at the end of the study...
2018: OncoTargets and Therapy
Ryan J Diel, Jodi Hwang, Zachary A Kroeger, Roy C Levitt, Constantine D Sarantopoulos, Heather Sered, Elizabeth R Felix, Jasmine Martinez-Barrizonte, Anat Galor
BACKGROUND: To evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients. METHODS: Retrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review...
September 29, 2018: British Journal of Ophthalmology
Michel Jabbour, Rawad Abou Zahr, Marielle Boustany
OBJECTIVE: To introduce a new protocol for patients with primary nocturnal enuresis to increase efficacy of treatment and decrease relapse rate. METHODS: A prospective study was done on 185 children diagnosed with nocturnal enuresis between the year 2007 and 2014. Inclusion criteria consisted of: age> 5 years, monosymptomatic enuresis or non-monosymptomatic enuresis, strict abidance by the protocol; follow up > 24 months. Exclusion criteria consisted of: secondary enuresis, poor compliance to protocol, neurogenic bladder...
September 24, 2018: Urology
Tania Mirza, Zubair Anwar, Muhammad Ahsan Ejaz, Sofia Ahmed, Muhammad Ali Sheraz, Iqbal Ahmad
The simultaneous assay of carboxymethylflavin (CMF), an intermediate in the photolysis of riboflavin, and its hydrolytic side-chain cleavage products, lumichrome (LC) (acid solution) and LC and lumiflavin (LF) as well as isoalloxazine ring cleavage products, 1,2-dihydro-1-methyl-2-keto-3-quinoxaline carboxylic acid (KA) and 1,2,3,4-tetrahydro-1-methyl-2,3-dioxo-quinoxaline (DQ) (alkaline solution) has been carried out by a multicomponent spectrofluorimetric method. The method is based on the adjustment of pH of the degraded solutions to 2...
September 27, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
Masako Tsukamoto, Katsuya Suzuki, Tsutomu Takeuchi
INTRODUCTION: Anti-centromere antibody (ACA)-positive Sjögren's syndrome (SS) is considered a subtype of SS. ACA-positive SS patients display several features, such as Raynaud's phenomenon, sclerodactyly, and extraglandular dysfunction. However, information on the features of ACA-positive SS is insufficient and the clinical significance of ACA in SS has not been fully established. The aim of this study was to clarify the features of ACA-positive SS. METHODS: All patients with primary SS who visited our hospital were enrolled...
September 25, 2018: Rheumatology and Therapy
Stavros Athanasiou, Eleni Pitsouni, Themos Grigoriadis, Dimitris Zacharakis, Matthew E Falagas, Stefano Salvatore, Athanasios Protopapas, Dimitris Loutradis
OBJECTIVE: The aim of this study is to assess the efficacy of microablative fractional CO2 laser therapy for genitourinary syndrome of menopause (GSM) management, when three, four, or five laser therapies were applied in a follow-up period of 12 months. METHODS: Retrospective study evaluating GSM symptoms at baseline, and 1, 3, 6, and 12 months after last laser therapy. Visual analog scale, International Consultation on Incontinence Questionnaires- Female Urinary Tract Symptoms, International Consultation on Incontinence Questionnaires-Urinary Incontinence Short Form, Urogenital Distress Inventory-6, and Female Sexual Function Index were used for assessment of GSM symptoms' intensity or bothering and parameters of sexual function...
September 24, 2018: Menopause: the Journal of the North American Menopause Society
Dawn Lemanne, Victoria Maizes
A majority of women undergoing conventional treatment for breast cancer also undertake complementary and integrative approaches. Practitioners knowledgeable about the evidence base behind common integrative approaches can help patients attain improved quality of life, and at times, improved survival. Evidence-based recommendations include the following: a plant-based diet for general health after diagnosis, and carbohydrate restriction for patients with estrogen receptor-positive postmenopausal breast cancer may be prudent...
September 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
I Jardin, G Canlorbe, J-L Mergui, M Nikpayam, J Belghiti, C Uzan, H Azaïs
Genitourinary syndrome of menopause (GSM) brings together a collection of signs including vaginal dryness, burning sensation and itching discomfort as well as deterioration of sexual health, dysuria, urgenturia and repeated urinary infections and may be responsible for a significant impairment of quality of life in symptomatic postmenopausal women. The management of GSM therefore represents a public health issue. Systemic or local hormonal treatments are frequently offered, as well as non-hormonal treatments...
September 18, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Susan R Davis, Penelope J Robinson, Fiona Jane, Shane White, Michelle White, Robin J Bell
Importance: Intra-vaginal testosterone (IVT) is a potential treatment for vulvovaginal atrophy (VVA) associated with aromatase inhibitor (AI) use. Objective: To investigate the effects of IVT on sexual satisfaction, vaginal symptoms and urinary incontinence (UI) associated with AI use. Design: Double-blind, randomized, placebo-controlled trial. Setting: Academic clinical research centre. Participants: Postmenopausal women taking an AI with VVA symptoms...
September 14, 2018: Journal of Clinical Endocrinology and Metabolism
Maria Concetta Rotolo, Manuela Pellegrini, Paola Martucci, Raffaela Giacobbe, Angela De Palma, Roberta Pacifici, Simona Pichini, Francesco Paolo Busardò, Mario Bisconti
Background Cannabis smoke affects the lungs similarly to tobacco smoke, causing symptoms such as increased cough, sputum, hyperinflation and chronic bronchitis. Chronic use can also cause serious lung diseases and airway obstruction. We developed and validated a method for the identification and quantification of cannabinol (CBN), cannabidiol (CBD), Δ-9-tetrahydrocannabinol (THC) and its metabolites 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THC-COOH) in bronchoalveolar lavages (BALs) from hospitalized former or current tobacco smoking patients with lung disease and a long history of cannabis consumption and limited current tobacco use...
September 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Xuan Sang, Yan Li, Liu Yang, Jia-Hui Liu, Xiao-Ran Wang, Chao-Yang Li, Ying Liu, Chen-Jie Wang, Xiong-Jun He, Shou-Bi Wang, Zhi-Chong Wang
AIM: To explore a new diagnostic index for differentiating the evaporative dry eye (EDE) subtypes by analysis of their respective clinical characteristics. METHODS: A cross-sectional study of 139 patients (139 eyes) with EDE who were enrolled and classified as obstructive meibomian gland dysfunction (MGD) ( n =81) and non-obstructive MGD ( n =58) EDE. All patients completed a Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire and were evaluated for average lipid layer thickness (LLT), tear meniscus height measurements (TMH), tear break-up time (TBUT), ocular surface staining score, Schirmer I test (SIT), lid margin abnormalities, and meibomian gland function and morphology...
2018: International Journal of Ophthalmology
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