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Renal histopathology

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https://www.readbyqxmd.com/read/29444269/association-of-angiotensin-ii-type-1-receptor-antibodies-with-graft-histology-function-and-survival-in-paediatric-renal-transplant-recipients
#1
Alexander Fichtner, Caner Süsal, Claudia Schröder, Britta Höcker, Susanne Rieger, Rüdiger Waldherr, Jens H Westhoff, Anja Sander, Duska Dragun, Burkhard Tönshoff
Background: We analysed in a carefully phenotyped cohort of paediatric patients the association of serum angiotensin II type 1 receptor antibodies (AT1R-Ab) with specific histological lesions and with graft function and survival in conjunction with overall and complement-binding donor-specific human leucocyte antigen donor-specific antibodies (HLA-DSA). Methods: Sera of 62 patients at the time of renal graft biopsy for clinical indication >1 year post-transplant were assessed for AT1R-Ab by enzyme-linked immunosorbent assay (ELISA) and for DSA and C1q-fixing DSA by single-antigen bead technology...
February 12, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29438840/efficacy-and-safety-of-combined-low-doses-of-either-diclofenac-or-celecoxib-with-gabapentin-versus-their-single-high-dose-in-treatment-of-neuropathic-pain-in-rats
#2
Mohamed A Ibrahim, Walaa Yehia Abdelzaher, Remon R Rofaeil, Soha Abdelwahab
Neuropathic pain is a worldwide health problem with no consensus regarding its optimal therapy. This study compared the analgesic effect and gastric, hepatic, and renal safety of combined low doses of diclofenac and celecoxib with gabapentin versus their individual high doses in the treatment of neuropathic pain in rats. Left sciatic nerve ligation was used as neuropathic pain model. Rats were allocated into 7 groups (7 rats for each): sham control; model group (received vehicle); Gaba-group (received gabapentin (100 mg/kg /day); Diclo 10-group (received diclofenac (10 mg/kg); Cele 10-group (received celecoxib (10 mg/kg/day); Gaba + Diclo 5 (receivedgabapentin(100 mg/kg /day) plus diclofenac (5 mg/kg); Gaba + Cele 5 (received gabapentin (100 mg/kg/day) plus celecoxib (5 mg/kg))...
February 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29437549/hepatic-and-renal-histology-and-mercury-concentrations-of-north-west-and-north-east-greenland-narwhals-monodon-monoceros
#3
Christian Sonne, Pall S Leifsson, Jens Søndergaard, Rune Dietz
Narwhals (Monodon monoceros) are at the top of the Arctic food web and therefore might biomagnify high total mercury (Hg) concentrations in organs and tissues. The aim of this study was to determine histopathology and Hg concentrations in liver and kidneys from 15 North East Greenland narwhals (3 subadult females, 8 adult females, 3 subadult males, and 1 adult male) and compare data with previous observations of 12 North West Greenland specimens (1 subadult female, 4 adult females, 1 subadult male, and 6 adult males)...
February 13, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29436671/protective-effect-of-curcumin-against-cyclosporine-a%C3%A2-induced-rat-nephrotoxicity
#4
Jianjun Huang, Xuping Yao, Guobin Weng, Honggang Qi, Xiaolei Ye
This study explored the potential value of curcumin, a natural product, in the protection of CsA‑induced nephrotoxicity. The aim of the present study was to investigate the effects of curcumin on Cyclosporine A (CsA)‑induced renal oxidative stress and determine the potential underlying molecular mechanisms of the renal protective effects of Cur. HK‑2 human renal cells were co‑treated with CsA and various doses of Cur. Cell survival rate was determined by an MTT assay, total cellular protein was collected and oxidative stress in cell homogenates was evaluated by determining the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px) and catalase (CAT), the levels of malondialdehyde (MDA) and reactive oxygen species (ROS), and total antioxidant capacity...
February 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29432674/shen-kang-protects-against-tacrolimus-induced-renal-injury
#5
Long Ye Zhang, Jian Jin, Kang Luo, Shang Guo Piao, Hai Lan Zheng, Ji Zhe Jin, Sun Woo Lim, Bum Soon Choi, Chul Woo Yang, Can Li
Background/Aims: Evidence suggests that Shen-Kang (SK), a traditional Chinese herbal medicine, protects against various types of renal injury. In this study, we evaluated whether SK treatment confers renoprotection in a rat model of chronic tacrolimus (TAC) nephropathy. Methods: Rats were treated daily with TAC (1.5mg/kg, subcutaneously) and SK (450 mg/kg, intravenously) for 4 weeks. The effects of SK on TAC-induced renal injury were assessed by measuring renal function, urine albumin excretion, histopathology, inflammatory cell infiltration, expression of profibrotic (transforming growth factor β1 [TGF-β1] and TGF-β inducible gene-h3 [βig-h3]) and proinflammatory cytokines, oxidative stress, and apoptotic cell death...
February 12, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29430229/pancreatic-pseudocyst-ruptured-due-to-acute-intracystic-hemorrhage
#6
Kunishige Okamura, Masanori Ohara, Tsukasa Kaneko, Tomohide Shirosaki, Aki Fujiwara, Takumi Yamabuki, Ryo Takahashi, Kazuteru Komuro, Nozomu Iwashiro, Noriko Kimura
Rupture of pancreatic pseudocyst is one of the rare complications and usually results in high mortality. The present case was a rupture of pancreatic pseudocyst that could be treated by surgical intervention. A 74-year-old man developed abdominal pain, vomiting, and diarrhea, and he was diagnosed with cholecystitis and pneumonia. Three days later, acute pancreatitis occurred and computed tomography (CT) showed slight hemorrhage in the cyst of the pancreatic tail. After another 10 days, CT showed pancreatic cyst ruptured due to intracystic hemorrhage...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29429165/-clinicopathologic-features-with-collecting-duct-carcinoma-of-kidney-report-of-10-cases
#7
J X Zhou, X R He, G X Song, Z G Zou, L H Wang, R Hu, H X Li
Objective: To study the pathological features, immunophenotypes, differential diagnoses and prognostic parameters of collecting duct carcinoma of the kidney (CDC). Methods: Clinical imaging, histopathology, immunohistochemistry, and survival data of 10 patients at First Affiliated Hospital of Nanjing Medical University from January 2009 to August 2017 were retrospectively analyzed along with a review of literatures. Results: The clinical symptoms of CDC were not specific, and image examinations showed space-occupying mass lesions...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29428974/malignant-rhabdoid-tumors-originating-within-and-outside-the-central-nervous-system-are-clinically-and-molecularly-heterogeneous
#8
Emilia M Pinto, Dima Hamideh, Armita Bahrami, Brent A Orr, Tong Lin, Stanley Pounds, Gerard P Zambetti, Alberto S Pappo, Amar Gajjar, Sameer Agnihotri, Alberto Broniscer
Multifocal synchronous or metachronous atypical teratoid rhabdoid tumors (ATRTs) and non-central nervous system malignant rhabdoid tumors (extra-CNS MRTs) are rare cancers. We reviewed the clinical and radiologic characteristics of affected patients seen at our institution. Genotyping and analysis of copy number abnormalities (CNAs) in SMARCB1 were performed in germline and tumor samples. Tumor samples underwent genome-wide DNA methylation and CNA analysis. The median age at diagnosis of 21 patients was 0.6 years...
February 10, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29427036/toxicological-effects-of-mercury-chloride-on-laying-performance-egg-quality-serum-biochemistry-and-histopathology-of-liver-and-kidney-in-laying-hens
#9
Yan Ma, Yizhen Shi, Lanlan Li, Chao Xie, Xiaoting Zou
The objective of this study was to determine the effects of mercury chloride (HgCl2) on laying performance, egg quality, hepatic and renal histopathology, and serum biochemical profiles in laying hens. A total of 768 Hy-line brown laying hens aged 40 weeks were randomly allocated to four groups (8 pens per group and 24 hens per pen). The concentrations of mercury (Hg) in four groups were 0.280, 3.325, 9.415, and 27.240 mg/kg. Results revealed that dietary Hg could significantly reduce laying performance (P < 0...
February 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29426280/blood-oxygen-level-dependent-magnetic-resonance-imaging-for-detecting-pathological-patterns-in-lupus-nephritis-patients-a-preliminary-study-using-a-decision-tree-model
#10
Huilan Shi, Junya Jia, Dong Li, Li Wei, Wenya Shang, Zhenfeng Zheng
BACKGROUND: Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive technique in renal disease. This current study was performed to explore whether BOLD MRI could contribute to diagnose renal pathological pattern. METHODS: Adult patients with lupus nephritis renal pathological diagnosis were recruited for this study...
February 9, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29425480/combined-administration-of-l-carnitine-and-ascorbic-acid-ameliorates-cisplatin-induced-nephrotoxicity-in-rats
#11
Quadri Kunle Alabi, Rufus Ojo Akomolafe, Olaoluwa Sesan Olukiran, Aliyat Olajumoke Nafiu, Modinat Adebukola Adefisayo, Olurotimi Isaac Owotomo, Joseph Gbenga Omole, Kehinde Peace Olamilosoye
OBJECTIVES: Cisplatin (CIS) is an effective antitumor drug. However, its clinical use is limited due to nephrotoxicity. l-Carnitine and vitamin C are both natural antioxidant that can be obtained from diets. This study investigated the effects of l-carnitine and/or vitamin C in rats against cisplatin-induced nephrotoxicity. METHODS: Twenty-five male Wistar rats were divided into 5 groups of 5 rats each. Group 1, normal control. Group 2, positive control, received cisplatin (10 mg/kg/day intraperitoneally [i...
February 9, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29424659/schistosomes-and-microfilarial-parasites-in-magellanic-penguins
#12
Ralph Vanstreels, Chris H Gardiner, Michael J Yabsley, Liandrie Swanepoel, Cristiane K M Kolesnikovas, Rodolfo P Silva-Filho, Ana C Ewbank, José L Catão-Dias
The Magellanic Penguin (Spheniscus magellanicus) is native to Argentina, Chile and the Falkland/Malvinas islands and is a regular winter migrant in Uruguayan and Brazilian coastal waters. The species is known to be susceptible to a variety of gastrointestinal nematodes, cestodes, trematodes and acanthocephalans, as well as renal trematodes and pulmonary nematodes. Schistosomes (Platyhelminthes, Trematoda, Schistosomatidae) and microfilariae (Nematoda, Secernentea, Onchocercidae) were histologically identified in Magellanic Penguins (Spheniscus magellanicus) that died while under care at rehabilitation centers in southern Brazil...
February 9, 2018: Journal of Parasitology
https://www.readbyqxmd.com/read/29423146/a-record-breaking-lung-metastasis-from-renal-cell-carcinoma-37-years-after-nephrectomy
#13
Alessandro Tamburrini, Aurelio Majorino, Simon Duggan, Sanjay Jogai, Aiman Alzetani
Development of distant metastases from renal cell carcinoma (RCC) is a frequent occurrence and, in nearly 95% of the cases, secondary lesions present within 5 years following nephrectomy. We performed a left pneumonectomy for a peri-hilar lung mass in an 81-year-old man with history of kidney cancer, resected 37 years earlier. Histopathological examination revealed a solitary lung metastasis from RCC, relapsed after an extraordinary 37-year time interval. To the best of our knowledge, this remarkable case represents the longest time interval between radical nephrectomy for RCC and the occurrence of a pulmonary metastasis...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29422999/potassium-bromate-induced-kidney-damage-in-rats-and-the-effect-of-gum-acacia-thereon
#14
Badreldin H Ali, Mohammed Al Za'abi, Turan Karaca, Yousuf Al Suleimani, Khalid A Al Balushi, Priyadarsini Manoj, Mohammed Ashique, Abderrahim Nemmar
Potassium bromate (KBrO3) is used in many countries in cosmetic and food industries. In this work, we investigated in male Sprague-Dawley rats, the effect of four graded oral doses of KBrO3 (5, 15, 45 and 135 mg/kg/day for 28 days) on renal function tests, inflammation, oxidative damage, and apoptosis, as well as on histopathology, using several traditional and novel renal injury biomarkers in plasma, urine and renal tissues. We also tested the possible ameliorative action of the renoprotective prebiotic agent gum acacia (GA) on the actions of KBrO3 when given concomitantly with it in the drinking water at a concentration of 15%w/v...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29421648/curcumin-ameliorates-cadmium-induced-nephrotoxicity-in-sprague-dawley-rats
#15
Kyeong Seok Kim, Hyun-Jung Lim, Jong Seung Lim, Ji Yeon Son, Jaewon Lee, Byung Mu Lee, Seung Chul Chang, Hyung Sik Kim
Chronic exposure to cadmium (Cd) causes remarkable damage to the kidneys, a target organ of accumulated Cd after oral administration. The aim of the present study was to investigate the protective effect of curcumin against Cd-induced nephrotoxicity. Sprague-Dawley male rats were divided into the following four treatment groups: control, curcumin (50 mg/kg, oral), CdCl2, (25 mg/kg, oral), and pre-treatment with curcumin (50 mg/kg) 1 h prior to the administration of CdCl2 (25 mg/kg, oral) for 7 days...
February 5, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29421595/improvement-of-cisplatin-induced-renal-dysfunction-by-schisandra-chinensis-stems-via-anti-inflammation-and-anti-apoptosis-effects
#16
Yan-Zi Li, Shen Ren, Xiao-Tong Yan, Yin-Shi Sun, Hui-Ping Li, Wei Li, Ying-Ying Liu, Zi Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandra chinensis (Turcz.) Baill (S. chinensis) is a frequently used traditional Chinese medicine, and modern pharmacological research has proven that S. chinensis has antioxidant, anti-hepatotox, anti-inflammatory, and anti-nephrotoxic effects. Cisplatin is widely used as antineoplastic drug at presenteffects, but the clinical application of cisplatin is limitedowing to nephrotoxicity. AIM OF THE STUDY: To demonstrate the renoprotective activity of the extract of the stems of Schisandra chinensis (SCE) in model mice established by cisplatin triggering acute kidney injury (AKI)...
February 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29417758/protective-effect-of-carvedilol-alone-and-coadministered-with-diltiazem-and-prednisolone-on-doxorubicin-and-5-fluorouracil-induced-hepatotoxicity-and-nephrotoxicity-in-rats
#17
Abidemi J Akindele, Gabriel O Oludadepo, Kennedy I Amagon, Dhirendra Singh, Daniel D Osiagwu
This study investigated the protective effects of carvedilol alone and coadministered with prednisolone and diltiazem on doxorubicin (DOX) and 5-fluorouracil (5-FU)-induced toxicity. Each of 2 pools of 70 female rats were randomly allotted into 10 groups of 7 animals each and treated as follows: Group 1: normal saline (10 mL/kg); Group 2: normal saline and DOX (40 mg/kg)/5-FU (20 mg/kg) alone; Group 3: gallic acid (200 mg/kg) and DOX/5-FU; Group 4: carvedilol (0.075 mg/kg) and DOX/5-FU; Group 5: carvedilol (0...
February 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29417279/tumors-of-the-parapharyngeal-space-the-vu-university-medical-center-experience-over-a-20-year-period
#18
Thijs van Hees, Stijn van Weert, Birgit Witte, C René Leemans
BACKGROUND: Tumors of the parapharyngeal space (PPS) are rare, accounting for 0.5-1.5% of all head and neck tumors. The anatomy of the PPS is responsible for a wide variety of tumors arising from the PPS. This series of 99 PPS tumors provides an overview of the clinical course and management of PPS tumors. MATERIALS AND METHODS: This retrospective study included clinical data from patients treated for PPS tumors from 1991 to 2012 (warranting at least a 4-year follow-up) at the VU University Medical Center, Amsterdam, The Netherlands...
February 7, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29416277/epidemiology-profile-of-renal-cell-carcinoma-a-10-year-patients-experience-at-king-abdulaziz-medical-city-national-guard-health-affairs-saudi-arabia
#19
Sarah Z Mahasin, Nourah Aloudah, Khaled Al-Surimi, Sultan S Alkhateeb
Purpose: The purpose of this study is to describe the epidemiological profile, histopathological features, and outcomes of patients diagnosed with renal cell carcinoma (RCC) in a tertiary referral center over 10 years. Methodology: This is a retrospective cohort of 219 Saudi patients diagnosed with RCC between June 2003 and May 2013. The variables collected included the sociodemographic details and clinical presentation. The histopathological features investigated include the tumors histological subtype, pathologic staging tumor, node, and metastasis descriptors, and lymph-vascular invasion...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29412002/close-pathological-correlations-between-chronic-kidney-disease-and-reproductive-organ-associated-abnormalities-in-female-cotton-rats
#20
Osamu Ichii, Teppei Nakamura, Takao Irie, Hirokazu Kouguchi, Kozue Sotozaki, Taro Horino, Yuji Sunden, Yaser Hosny Ali Elewa, Yasuhiro Kon
Cotton rat ( Sigmodon hispidus) is a useful experimental rodent for the study of human infectious diseases. We previously clarified that cotton rats, particularly females, developed chronic kidney disease characterized by cystic lesions, inflammation, and fibrosis. The present study investigated female-associated factors for chronic kidney disease development in cotton rats. Notably, female cotton rats developed separation of the pelvic symphysis and hypertrophy in the vaginal parts of the cervix with age, which strongly associated with pyometra...
January 1, 2018: Experimental Biology and Medicine
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