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Renal histopathology

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https://www.readbyqxmd.com/read/29667662/camel-milk-attenuates-methotrexate-induced-kidney-injury-via-activation-of-pi3k-akt-enos-signaling-and-intervention-with-oxidative-aberrations
#1
Hany H Arab, Samir A Salama, Ibrahim A Maghrabi
Methotrexate (MTX) is a classical chemotherapeutic agent with nephrotoxicity as the most disturbing adverse effect. So far, its underlying molecular mechanisms, particularly PI3K/Akt/eNOS transduction, are inadequately explored. Several antioxidant modalities have been characterized to ameliorate MTX-induced renal injury. In this regard, Camel milk (CM) is a natural product with recognized antioxidant and anti-inflammatory features. Thus, the current study aimed to investigate the potential ameliorating effects of CM in MTX-induced kidney injury in rats...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29665653/upregulation-of-ppar-%C3%AE-mediates-the-renoprotective-effect-of-omega-3-pufa-and-ferulic-acid-in-gentamicin-intoxicated-rats
#2
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Sara A Helal
Ferulic acid (FrA) is a natural product containing phenolic compounds. ω-3 PUFA is the major constituent of fish oil. The aim of this study was to investigate the renoprotective role of FrA and FO in gentamicin (GM)-induced nephrotoxicity in rats. Forty four male rats were divided equally into 4 groups: Control group, GM group, FrA + GM group and FO + GM group. Each of the treated groups was injected with GM (40 mg/kg) i.p. for 9 consecutive days. FrA (100 mg/kg) and FO (5 mL/kg) were given to rats orally daily for 10 days prior to GM and then concomitantly with GM for additional 9 days...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29664511/bullous-henoch-sch%C3%A3-nlein-purpura-case-report
#3
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29660027/the-6-hydroxychromanol-derivative-sul-109-ameliorates-renal-injury-after-deep-hypothermia-and-rewarming-in-rats
#4
Pieter C Vogelaar, Maurits Roorda, Edwin L de Vrij, Martin C Houwertjes, Maaike Goris, Hjalmar Bouma, Adrianus C van der Graaf, Guido Krenning, Robert H Henning
Background: Mitochondrial dysfunction plays an important role in kidney damage in various pathologies, including acute and chronic kidney injury and diabetic nephropathy. In addition to the well-studied ischaemia/reperfusion (I/R) injury, hypothermia/rewarming (H/R) also inflicts acute kidney injury. Substituted 6-hydroxychromanols are a novel class of mitochondrial medicines that ameliorate mitochondrial oxidative stress and protect the mitochondrial network. To identify a novel 6-hydroxychromanol that protects mitochondrial structure and function in the kidney during H/R, we screened multiple compounds in vitro and subsequently assessed the efficacy of the 6-hydroxychromanol derivatives SUL-109 and SUL-121 in vivo to protect against kidney injury after H/R in rats...
April 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29659362/-recurrent-atypical-hemolytic-uremic-syndrome-after-renal-transplantation-treatment-with-eculizumab
#5
Ana B Latzke, Pehuén Fernández, Carlos Chiurchiu, Daniela Sarmantano, Javier De Arteaga, Walter Douthat, Jorge De la Fuente
Atypical hemolytic uremic syndrome (aHUS) is a rare entity. It is characterized by a thrombotic microangiopathy (nonimmune hemolytic anemia, thrombocytopenia, and acute renal failure), with a typical histopathology of thickening of capillary and arteriolar walls and an obstructive thrombosis of the vascular lumen. The syndrome is produced by a genetic or acquired deregulation of the alternative pathway of the complement system, with high rates of end stage renal disease, post-transplant recurrence, and high mortality...
2018: Medicina
https://www.readbyqxmd.com/read/29657209/spectrum-of-biopsy-proven-renal-diseases-a-single-center-experience
#6
Lakshminarayana R Gopaliah, Indu Sudakaran, Seethalekshmy Vijayan Nalumakkal, Ranjit Narayanan, Biju Meckattuparamban Vareed
Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopathological diagnosis promotes evidence-based practice in Nephrology. This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77.78%) followed by secondary glomerular diseases (SGD) (12...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29657199/impact-of-body-mass-index-on-progression-of-primary-immunoglobulin-a-nephropathy
#7
Shankar Prasad Nagaraju, Dharshan Rangaswamy, Aswani Srinivas Mareddy, Srikanth Prasad, Sindhu Kaza, Srinivas Shenoy, Karan Saraf, Ravindra Prabhu Attur, Rajeevalochana Parthasarathy, Srinivas Kosuru, Uday Venkat Mateti, Vasudeva Guddattu, Sindhura Lakshmi Koulmane Laxminarayana
The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29656179/novel-reno-protective-mechanism-of-aspirin-involves-h2ak119-monoubiquitination-and-set7-in-preventing-type-1-diabetic-nephropathy
#8
Santosh Kumar Goru, Anil Bhanudas Gaikwad
BACKGROUND: Even after several novel therapeutic approaches, the number of people with diabetic nephropathy (DN) still continues to increase globally, this suggest to find novel therapeutic strategies to prevent it completely. Recent reports, are indicating the ubiquitin proteasome system alterations in DN. Recently, we also showed that, histone H2AK119 mono-ubiquitination (H2AK119-Ub) found to regulate Set7, a key epigenetic enzyme in the development of renal fibrosis under type 1 diabetic condition...
December 2, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29650267/virtual-touch-tissue-quantification-for-assessing-renal-pathology-in-idiopathic-nephrotic-syndrome
#9
Xue Yang, Ning Yu, Jing Yu, Hongqiao Wang, Xiumei Li
The aim of this study was to evaluate Virtual Touch tissue quantification in assessing renal interstitial fibrosis in patients with idiopathic nephrotic syndrome. Ninety patients with idiopathic nephrotic syndrome were assigned to mild, moderate and severe groups depending on the degree of renal interstitial fibrosis on histopathologic examination of renal biopsy specimens. Thirty healthy patients were also selected as the control group. Virtual Touch tissue quantification was performed to measure the shear wave velocity of the renal parenchyma...
April 9, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29644063/metabolic-adaptability-in-hexavalent-chromium-treated-renal-tissue-an-in-vivo-study
#10
Kanu Shil, Sudipta Pal
Background: Hexavalent chromium [Cr(VI)], an environmental pollutant that originates mostly from anthropogenic sources, is a serious threat to human health. After entering into cells, Cr(VI) is capable of producing excessive free radicals and causing tissue damage. The present study aims to reveal the toxic manifestation of Cr(VI) on the metabolic activity of renal tissue. Methods: Male Swiss albino mice were treated orally with potassium dichromate (K2 Cr2 O7 ) at a dose of 10 mg/kg body weight for a period of 30 days...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29643988/combination-therapy-of-chitosan-gynostemma-and-motherwort-alleviates-the-progression-of-experimental-rat-chronic-renal-failure-by-inhibiting-stat1-activation
#11
Wenxia Bai, Shudong Wang, Shanshan An, Mengjie Guo, Guangming Gong, Wenya Liu, Shaoxin Ma, Xin Li, Jihua Fu, Wenbing Yao
This study aimed to investigate the effect of single and combination therapy using chitosan (K), gynostemma (J), and motherwort (Y) on an experimental rat model of chronic renal failure (CRF) induced by adenine and the underlying mechanisms. CRF rats were treated with individual or combinational therapy with two or three of these agents. Biochemical indicators showed that the levels of blood urea nitrogen, creatinine and uric acid decreased and the levels of albumin and hemoglobin increased by single or combination therapy of these drugs...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29626589/red-onion-scales-ameliorated-streptozotocin-induced-diabetes-and-diabetic-nephropathy-in-wistar-rats-in-relation-to-their-metabolite-fingerprint
#12
Tarek Kamal Abouzed, María Del Mar Contreras, Kadry Mohamed Sadek, Moustafa Shukry, Doaa Abdel Hady, Wael Mohamed Gouda, Walied Abdo, Nasr Elsayed Nasr, Reham Hassan Mekky, Antonio Segura-Carretero, Khaled Abdel-Aleim Kahilo, Essam Abdel-Sattar
AIM: The present study was designed to investigate the effect of red onion scales extract (ROS) against diabetic nephropathy, in relation to its metabolic profiling. METHODS: Four groups of male Wistar rats were assigned as follows; 1st untreated group, 2nd group (animals with diabetes) treated with streptozotocin (STZ, 50mg/kg) IP, 3rd group co-treated with ROS (150mg/kg + STZ, 50mg/kg) and 4th group co-treated with ROS by a dose (300mg/kg + STZ, 50mg/kg) daily...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29625388/crocin-reverses-unilateral-renal-ischemia-reperfusion-injury-induced-augmentation-of-oxidative-stress-and-toll-like-receptor-4-activity
#13
Hadeer O Abou-Hany, Hoda Atef, Eman Said, Hassan A Elkashef, Hatem A Salem
Renal Ischemia (RI) usually develops as a secondary manifestation of hypertension, various cardiovascular disorders and renal transplantation. It exerts hypoxic oxidative stress to kidneys, together with stimulation of several immune-mediated inflammatory cascades. Such events eventually damage renal tubules and glomeruli, driving acute kidney injury (AKI) and ultimately, renal failure. Crocin; the main bioactive constituent of Crocus sativus extract has been reported to demonstrate numerous pharmacological merits...
March 27, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29620646/multiple-metastases-of-clear-cell-renal-cell-carcinoma-to-different-region-of-the-nasal-cavity-and-paranasal-sinus-3-times-successively-a-case-report-and-literature-review
#14
Na Zhang, Bing Zhou, Qian Huang, Xiaohong Chen, Shunjiu Cui, Zhenxiao Huang, Yan Sun
RATIONALE: Distant metastasis of clear-cell renal cell carcinoma (ccRCC) to the nasal cavity and paranasal sinus is rare. Endoscopic biopsy used to be performed for diagnosis when it is difficult for complete resection due to intense bleeding during surgery. According to previous literature, the outcomes of metastasis after endoscopic surgery remain unclear. PATIENT CONCERNS: A 62-year-old man with a history of epistaxis was referred to our institution. The clinical, computed tomography (CT) and magnetic resonance imaging (MRI) examination indicate metastasis to sinonasal sinuses...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29617505/evaluation-of-the-effects-of-atorvastatin-and-ischemic-postconditioning-preventing-on-the-ischemia-and-reperfusion-injury-experimental-study-in-rats
#15
Henrique Budib Dorsa Pontes, José Carlos Dorsa Vieira Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, João Victor Cunha Miranda, Letícia do Espírito Santos Dias, João Victor Durães Gomes Oliva, Murilo Henrique Martins de Almeida, Ian de Oliveira Chaves, Tricia Luna Sampaio, Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado
INTRODUCTION: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29608980/renoprotective-effects-of-umbelliferone-on-methotrexate-induced-renal-injury-through-regulation-of-nrf-2-keap-1-p-38-mapk-nf-%C3%AE%C2%BAb-and-apoptosis-signaling-pathways
#16
Emad H M Hassanein, Wafaa R Mohamed, Abdel-Gawad S Shalkami, Marwa M Khalaf, Ramadan A M Hemeida
Nephrotoxicity is the major dose-limiting adverse effect of methotrexate (MTX). Umbelliferone (UMB) is a known coumarin derivative. The current study aimed to investigate possible protective effects of UMB against MTX-induced nephrotoxicity. Adult male albino rats were divided into: control group, UMB group (30 mg/kg, p.o), MTX group (single i.p. injection of 20 mg/kg) and MTX + UMB group. Serum urea and creatinine were evaluated. The renoprotective effects of UMB were evaluated by estimation of renal Nrf-2/Keap-1 and P38 MAPK/NF-κB, GSH, MDA, NO2 - contents and SOD activity...
March 30, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29608440/serum-and-urine-toxicometabolomics-following-gentamicin-induced-nephrotoxicity-in-male-sprague-dawley-rats
#17
Sung Ha Ryu, Ji Won Kim, Dahye Yoon, Suhkmann Kim, Kyu-Bong Kim
Gentamicin (GM) is an aminoglycoside antibiotic used in treatment of various types of bacterial infections, but the major adverse effect is drug-induced nephrotoxicity. This study aimed to determine biomarkers that might predict nephrotoxicity initiated by GM using serum or urinary proton nuclear magnetic resonance (1 H NMR) spectral data in male Sprague-Dawley rats. GM (0, 30, or 300 mg/kg/d) was intraperitoneally administered for 3 consecutive days. Animals were sacrificed 2 d (D2) or 8 d (D8) after last administration of GM in order to perform analysis of serum biochemistries and histopathologic examination...
April 2, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29607610/recurrent-igg4-related-tubulointerstitial-nephritis-concurrent-with-chronic-active-antibody-mediated-rejection-a-case-report
#18
Rajni Chibbar, Glenda R Wright, Pouneh Dokouhaki, Sandi Dumanski, Bhanu Prasad, Michael Mengel, Lynn D Cornell, Ahmed Shoker
IgG4-related disease is a relatively newly described entity that can affect nearly any organ, including the kidneys, when it usually manifests as tubulointerstitial nephritis (IgG4-TIN). The diagnosis can be suggested by characteristic histological features, including an inflammatory infiltrate with increased IgG4 positive plasma cells associated with "storiform" fibrosis. Serum IgG4 is usually elevated. In the native kidney and other organs, there is typically a brisk response to treatment with immunosuppression...
April 1, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29607435/renal-clear-cell-sarcoma-presenting-as-a-spontaneous-renal-hematoma-a-rare-presentation
#19
Zeynep Canan Ozdemir, Burcu Ayvaci, Yeter Duzenli Kar, Mehmet Oguzman, Mehmet Surhan Arda, Mustafa Fuat Acikalin, Ozcan Bor
Clear cell sarcoma of the kidney (CCSK) is an uncommon renal neoplasm of childhood. It represents between 2% and 9% of all pediatric renal tumors, and generally arises before the age of 5 years. It often mimics other pediatric renal tumors. Presently described is the case of a 7-year-old girl who presented with complaints of vomiting and abdominal pain. Abdominal ultrasonography revealed a right renal mass, and the patient developed a renal hematoma a few hours after admission. The patient underwent a nephroureterectomy with a provisional diagnosis of Wilms tumor; however, histopathological examination of a specimen revealed CCSK...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29605795/acute-and-chronic-toxicity-assessment-of-benzylpenicillin-g-residue-in-heat-treated-animal-food-products
#20
Cheng Cui, Xiang Zhang, Yang Wang, Shiying Lu, Huijun Lu, Qi Hui, Waqas Ahmad, Yan Cai, Xilin Liu, Lingjiu Liu, Fengfeng Shi, Yanyan Liu, Ke Zhao, FeiFei Zhai, Yangzhen Xiang, Pan Hu, Yansong Li, Honglin Ren, Ningyi Jin, Zengshan Liu
The current level of penicillin use and its persisting residue in livestock is potentially concerning; the toxicity of penicillin residue in heat-treated animal food products (HAFP) is yet to be elucidated. In this study, the acute and chronic toxicity of benzylpenicillin G (BPG) residue in HAFP was investigated in a mouse model. The calculated LD50 of BPG heated to cooking temperature (BPHCT) was 933.04 mg kg-1 [b.w.] intraperitoneally corresponding to 3.75 times lower than its prototype. Mice fed on the experimental diet containing heat-treated beef with high BPG levels for 6 months displayed a reduction in body weight and altered serum values indicating for liver and renal function...
March 14, 2018: Chemosphere
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