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Renal histopathology

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https://www.readbyqxmd.com/read/29049207/cutaneous-mucormycosis-in-a-patient-with-lupus-nephritis-a-case-report-and-review-of-literature
#1
Wenrong Cheng, Guoqin Wang, Min Yang, Lijun Sun, Hongrui Dong, Yipu Chen, Hong Cheng
RATIONALE: Mucormycosis is a rare fungal infection but life-threatening, especially in lupus nephritis (LN). Mucormycosis may manifest as rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal, renal, or disseminated forms. PATIENT CONCERNS: We report a case of a 52-year-old woman with cutaneous mucormycosis infection who was admitted because of LN. DIAGNOSES: Histopathological analysis of the lesion confirmed the Rhizopus microspores from the family Mucoraceae...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29045942/quantitative-renal-echogenicity-as-a-tool-for-diagnosis-of-advanced-chronic-kidney-disease-in-patients-with-glomerulopathies-and-no-liver-disease
#2
Alexandre B Libório, Fernanda Macedo de Oliveira Neves, Candice Bezerra Torres de Melo, Tacyano Tavares Leite, Renata de Almeida Leitão
BACKGROUND/AIMS: Glomerulopathy patients are prone to developing transitory reduced glomerular filtration rate (GFR), which can be difficult to differentiate from irreversible chronic kidney disease (CKD). Renal ultrasound can be useful, but differently from renal length, quantitative renal echogenicity has not been formerly evaluated regarding its capacity to identify irreversible advanced CKD. METHODS: A prospective study was performed, where quantitative renal echogenicity was performed during renal biopsy in patients with suspected glomerular disease (n=197)...
October 18, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29043663/nephrotoxicity-induced-by-cisplatin-intake-in-experimental-rats-and-therapeutic-approach-of-using-mesenchymal-stem-cells-and-spironolactone
#3
Mohamed M Elseweidy, Mervat E Askar, Sahar E Elswefy, Mohamed Shawky
Chronic kidney disease may lead to subsequent tissue fibrosis. However, many factors can combat injurious stimuli in these tissues aiming to repair, heal, and alleviate any disturbance. Chemokines release, migration of inflammatory cells to the affected site, and activation of fibroblasts for the production of extracellular matrix are commonly observed in this disease. In the last years, many studies have focused on spironolactone (SPL), a mineralocorticoid receptor antagonist, and its pharmacological effects...
October 17, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29042953/oral-colon-specific-drug-delivery-system-reduces-the-nephrotoxicity-of-rhubarb-anthraquinones-when-they-produce-purgative-efficacy
#4
Pei Liu, Hongwei Wei, Jinhua Chang, Guangxin Miao, Xigang Liu, Zhongsi Li, Liyan Liu, Xiangrong Zhang, Cuizhe Liu
Rhubarb is commonly used to treat constipation in China and anthraquinones (AQs) are the active components present in rhubarb. However, an increasing number of studies have reported that AQs induce nephrotoxicity. In the present study, rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) were prepared to determine whether RTFA-OCDD-GN could reduce the nephrotoxicity that occurs when AQs produce purgative efficacy. RTFA-OCDD-GN were prepared using pH-enzyme double-layer coating technology and the cumulative release rate of RTFA in RTFA-OCDD-GN was assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040902/primary-ewing-s-sarcoma-of-the-kidney-a-case-report
#5
Faris Alasmari, Hani Albadawe, Sultan Alkhateeb, Fahd Alsufiani, Samirah Ghandurah
This is a 15-year-old female who presented with sudden onset left flank pain associated with nausea and vomiting and a history of weight loss. Radiological investigation revealed a large non-obstructive tumor involving the lower pole of the left kidney which was primarily thought to be a renal cell carcinoma. She underwent left open radical nephrectomy with adrenalectomy. Histopathology of the resected specimen showed features of Ewing's sarcoma of the kidney which was confirmed by cytogenetic analysis. This is a rare disease especially in the pediatric group and in reporting such a rare case we hope it helps in identifying a potential course of the disease and its response to the involved treatment...
October 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29037869/uremic-leontiasis-ossea-a-rare-presentation-of-severe-renal-osteodystrophy-secondary-to-hyperparathyroidism
#6
Francisca Donoso Hofer, Matías Gunther-Wood, Pablo Romero-Romano, Natalia Pezoa-Opazo, María de Los Ángeles Fernández-Toro, Ana Verónica Ortega-Pinto
Renal osteodystrophy is a common complication of end-stage renal failure patients. It's most severe osseous complication is characterized by massive thickening of the cranial vault and facial bones, called uremic leontiasis ossea (ULO), with only few cases reported in the literature. A case of a 47-year-old female patient with ULO is presented. Physical examination showed enlargement of the jaws which hinders proper ventilation and feeding. The computed tomography examination showed marked osseous proliferation in the jaws causing severe bony expansion and loss of normal bony architecture in the skull and the skull base...
October 13, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29037475/chronic-arsenicosis-and-cadmium-exposure-in-wild-snowshoe-hares-lepus-americanus-breeding-near-yellowknife-northwest-territories-canada-part-1-evaluation-of-oxidative-stress-antioxidant-activities-and-hepatic-damage
#7
S Amuno, A Jamwal, B Grahn, S Niyogi
Previous gold mining activities and arsenopyrite ore roasting activities at the Giant mine site (1948 to 2004) resulted in the release of high amounts of arsenic and trace metals into the terrestrial and aquatic ecosystems of Yellowknife, Northwest Territories, Canada. While elevated levels of arsenic has been consistently reported in surface soils and vegetation near the vicinity of the Giant mine area and in surrounding locations, systematic studies evaluating the overall health status of terrestrial small mammals endemic to the area are lacking...
October 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29034189/antidiabetic-activity-of-extracts-of-anacardium-occidentale-linn-leaves-on-n-streptozotocin-diabetic-rats
#8
Y S Jaiswal, P A Tatke, S Y Gabhe, A B Vaidya
Anacardium occidentale L. (Anacardiaceae) is used in South Cameroon as well as in other tropical countries by traditional practitioners as a folk remedy for treatment of diabetes mellitus. We demonstrated the antidiabetic potential of the plant extracts in n-streptozotocin diabetic rats. The aim of the current study was to investigate the antidiabetic effects of ethanol extract of leaves of A. occidentale on neonatal streptozotocin diabetic rats. Two day old neonates were injected with 100 mg/kg of streptozotocin...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033814/a-case-of-aplasia-cutis-congenita-type-vi-bart-syndrome
#9
Yasmin Alfayez, Sahar Alsharif, Adel Santli
Aplasia cutis congenita type VI, also known as Bart syndrome, is a rare genetic mechanobullous disorder characterized by congenital localized absence of skin, mucocutaneous blistering lesions, and nail abnormalities. We present the case of a 4-h-old male newborn who presented with complete absence of skin over the anteromedial aspect of both lower legs associated with nail dystrophy since birth. After a few days, he developed blisters that were consistent with epidermolysis bullosa in histopathological examination...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29033543/effect-of-echinacoside-on-kidney-fibrosis-by-inhibition-of-tgf-%C3%AE-1-smads-signaling-pathway-in-the-db-db-mice-model-of-diabetic-nephropathy
#10
Fengjuan Tang, Yarong Hao, Xue Zhang, Jian Qin
Kidney fibrosis and renal tubular epithelial-to-mesenchymal transition (EMT) are the main pathological changes of diabetic nephropathy (DN), which eventually leads to end-stage renal disease. Previous studies have suggested that echinacoside (ECH) is antifibrotic in the liver. However, the effect of ECH on kidney fibrosis in DN and its mechanisms are unknown. This study was performed to explore the effect of ECH on kidney fibrosis and also the molecular mechanisms of ECH in a db/db mice model of DN. Our results showed that, relative to db/db mice, the mice in the ECH group had an improved general state and reduced blood glucose and 24-hour urinary protein levels...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29032332/long-term-treatment-with-chaethomellic-acid-a-reduces-glomerulosclerosis-and-arteriolosclerosis-in-a-rat-model-of-chronic-kidney-disease
#11
António Nogueira, Helena Vala, Carmen Vasconcelos-Nóbrega, Ana Isabel Faustino-Rocha, Carlos André Pires, Aura Colaço, Paula Alexandra Oliveira, Maria João Pires
The high prevalence of end-stage renal disease emphasizes the failure to provide therapies to effectively prevent and/or reverse renal fibrosis. Therefore, the aim of this study was to evaluate the effect of long-term treatment with chaethomellic acid A (CAA), which selectively blocks Ha-Ras farnesylation, on renal mass reduction-induced renal fibrosis. Male Wistar rats were sham-operated (SO) or subjected to 5/6 renal mass reduction (RMR). One week after surgery, rats were placed in four experimental groups: SO:SO rats without treatment (n=13); SO+CAA: SO rats treated with CAA (n=13); RMR:RMR rats without treatment (n=14); and RMR+CAA:RMR rats treated with CAA (n=13)...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030177/eprosartan-mesylate-loaded-bilosomes-as-potential-nano-carriers-against-diabetic-nephropathy-in-streptozotocin-induced-diabetic-rats
#12
Abdul Ahad, Mohammad Raish, Ajaz Ahmad, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
The objective of the present study was to formulate eprosartan mesylate loaded nano-bilosomes and investigates its potential for controlling streptozotocin induced diabetes nephropathy in Wistar rats. The eprosartan mesylate loaded nano-bilosomes comprising of various ratios of soybean phosphatidylcholine/sodium deoxycholate were prepared by thin film hydration technique. The prepared formulations were evaluated for vesicles size, polydispersity index, zeta potential and entrapment efficiency. Further the optimized formulation was characterized for vesicles morphology, and its efficacy for the management of diabetic nephropathy in Wistar rats...
October 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29030026/nephroprotective-effect-of-electrolyzed-reduced-water-against-cisplatin-induced-kidney-toxicity-and-oxidative-damage-in-mice
#13
Tse-Chou Cheng, Yu-Wen Hsu, Fung-Jou Lu, Ya-Yu Chen, Nu-Man Tsai, Wen-Kang Chen, Chia-Fang Tsai
BACKGROUND: Cisplatin is a potent chemotherapeutic drug for cancer therapy, but it has serious side effects in clinical treatment, particularly nephrotoxicity. The purpose of this study was to evaluate the protective effect of electrolyzed reduced water (ERW) on renal injury caused by cisplatin. METHODS: Animals were divided into four groups as follows: normal control group, cisplatin control group, ERW control group and ERW + cisplatin group. Each group comprised 10 animals, which were orally treated with normal saline or ERW daily companion by administration of one dose of cisplatin for 28 days...
October 10, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29027259/early-urinary-biomarkers-of-renal-tubular-damage-by-a-high-salt-intake-independent-of-blood-pressure-in-normotensive-rats
#14
Satoshi Washino, Keiko Hosohata, Denan Jin, Shinji Takai, Tomoaki Miyagawa
Dietary sodium intake has been associated with progression to chronic kidney disease (CKD) as well as hypertension. A high-salt intake causes renal damage independent of hypertension. Because traditional renal biomarkers are insensitive, it is difficult to detect renal injury induced by a high-salt intake, especially in normotensive patients. Here, we investigated whether newly developed renal biomarkers could be detected earlier than traditional biomarkers under a high-salt intake, in normotensive rats. Male Wistar Kyoto rats (WKY) received a regular (0...
October 12, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29027199/characterization-of-a-mouse-model-of-sickle-cell-trait-parallels-to-human-trait-and-a-novel-finding-of-cutaneous-sensitization
#15
Katherine J Zappia, Yihe Guo, Dawn Retherford, Nancy J Wandersee, Cheryl L Stucky, Cheryl A Hillery
Sickle cell trait (SCT) has classically been categorized as a benign condition except in rare cases or upon exposure to severe physical conditions. However, several lines of evidence indicate that individuals with SCT are not always asymptomatic, and additional physiological changes and risks may remain unexplored. Here, we utilized mice harbouring one copy of normal human β globin and one copy of sickle human β globin as a model of SCT to assess haematological, histopathological and somatosensory outcomes...
October 12, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29026167/the-proteasome-inhibitor-bortezomib-attenuates-renal-fibrosis-in-mice-via-the-suppression-of-tgf-%C3%AE-1
#16
Moko Zeniya, Takayasu Mori, Naofumi Yui, Naohiro Nomura, Shintaro Mandai, Kiyoshi Isobe, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Kidney fibrosis and fibrogenesis significantly exacerbate chronic kidney disease (CKD) progression and are essential therapeutic targets. Bortezomib (BZM) is a proteasome inhibitor used for the treatment of multiple myeloma (MM). Several studies have demonstrated that BZM attenuates renal impairment in patients with MM, although this effect is generally considered to be the result of MM remission. Recently, several studies on BZM reported anti-fibrotic effects on liver and skin in experimental animal models...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025319/the-effects-of-salvia-przewalskii-total-phenolic-acid-extract-on-immune-complex-glomerulonephritis
#17
Yang Yang, Zhi-Peng Wang, Shou-Hong Gao, Hong-Qi Ren, Ren-Qian Zhong, Wan-Sheng Chen
CONTEXT: Salvia przewalskii Maxim. (Lamiaceae) is a Chinese herbal medicine that has long been used for the treatment of cardiovascular disease. OBJECTIVE: The study investigated the therapeutic efficacy of S. przewalskii total phenolic acid extract (SPE) on immune complex glomerulonephritis (ICG) in rats. MATERIALS AND METHODS: Sixty-two Wistar rats were randomized into six groups. ICG was induced in all groups except normal control group...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29024717/supplementation-of-american-ginseng-berry-extract-mitigated-cisplatin-evoked-nephrotoxicity-by-suppressing-ros-mediated-activation-of-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#18
Zhi-Na Ma, Zhi Liu, Zi Wang, Shen Ren, Shan Tang, Ying-Ping Wang, Sheng-Yuan Xiao, Chen Chen, Wei Li
Nephrotoxicity induced by cisplatin in 30% of all cisplatin treated patients seriously limits its clinical implication as a widely used anticancer agent, and may even cause patients to alter or give up cisplatin therapy. The purpose of this study is to test a protective effect of American ginseng berry extract (AGBE) on cisplatin-induced nephrotoxicity in mice. In this study, the histopathological changes and elevated levels of serum creatinine (CRE) and urea nitrogen (BUN) caused by cisplatin were significantly diminished by AGBE treatment...
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29023154/diagnostic-performance-of-dwi-for-differentiating-high-from-low-grade-clear-cell-renal-cell-carcinoma-a-systematic-review-and-meta-analysis
#19
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
OBJECTIVE: The purpose of our study was to review the diagnostic performance of DWI for differentiating high- from low-grade clear cell renal cell carcinoma (RCC). MATERIALS AND METHODS: MEDLINE, EMBASE, and Cochrane library databases were searched up to March 15, 2017. We included diagnostic accuracy studies that used DWI for differentiating high- from low-grade clear cell RCC compared with histopathologic results of Fuhrman grade based on nephrectomy or biopsy specimens in original research articles...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29023056/ameliorative-effect-of-arctium-lappa-against-cadmium-genotoxicity-and-histopathology-in-kidney-of-wistar-rat
#20
Asma Suliman Al-Gebaly
BACKGROUND AND OBJECTIVE: Cadmium (Cd) is a non-essential metal whose dispersion in the environment has increased recently, Cd may enhance cell oxidative stress that leads to DNA damage and apoptotic cell death. The study aimed to evaluate the antioxidative capability of Burdock root 'Arctium lappa' on cadmium-induced oxidative stress and histopathology of the kidney of Wistar rats. METHODOLOGY: Cadmium was applied in a form of cadmium chloride to three groups (15 mg Cd kg-1) for five weeks with two groups pre-treated with 'Arctium lappa' administration, 100 and 200 mg kg-1 b...
2017: Pakistan Journal of Biological Sciences: PJBS
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