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https://www.readbyqxmd.com/read/30079380/distinct-transcriptional-responses-of-mouse-sensory-neurons-in-models-of-human-chronic-pain-conditions
#1
M A Bangash, Sascha R A Alles, Sonia Santana-Varela, Queensta Millet, Shafaq Sikandar, Larissa de Clauser, Freija Ter Heegde, Abdella M Habib, Vanessa Pereira, Jane E Sexton, Edward C Emery, Shengnan Li, Ana P Luiz, Janka Erdos, Samuel J Gossage, Jing Zhao, James J Cox, John N Wood
Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression using microarrays in mouse models related to human chronic pain. Methods: Six different pain models were studied in male C57BL/6J mice: (1) bone cancer pain using cancer cell injection in the intramedullary space of the femur; (2) neuropathic pain using partial sciatic nerve ligation; (3) osteoarthritis pain using mechanical joint loading; (4) chemotherapy-induced pain with oxaliplatin; (5) chronic muscle pain using hyperalgesic priming; and (6) inflammatory pain using intraplantar complete Freund's adjuvant...
2018: Wellcome Open Research
https://www.readbyqxmd.com/read/30055762/orbital-pseudotumor-presenting-as-a-temporomandibular-disorder-a-case-report-and-review-of-literature
#2
Mythili Kalladka, Sowmya Ananthan, Eli Eliav, Cibele Nasri-Heir, Junad Khan, Gary Heir
BACKGROUND AND OVERVIEW: Orofacial pain has multifactorial causes and is often a diagnostic challenge. Misdiagnosis can result in morbidity or mortality due to misdirected and inappropriate treatment. A delay of necessary treatment, in cases of ominous illnesses, may result in its perpetuation or progression. The authors present a case report that illustrates these possibilities. CASE DESCRIPTION: This case report describes a 36-year-old woman with the chief symptom of painless, limited mandibular movement...
July 24, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/30010971/treatment-based-classification-system-for-patients-with-low-back-pain-the-movement-control-approach
#3
Muhammad Alrwaily, Michael Timko, Michael Schneider, Greg Kawchuk, Christopher Bise, Karthik Hariharan, Joel Stevans, Anthony Delitto
We present the movement control approach as part of the treatment-based classification system. This approach proposes a movement control schema that clarifies that movement control is a product of the interplay among multiple biopsychosocial components. The schema illustrates that for movement to occur in a dynamically controlled fashion, the lumbar spine requires both local mobility and global stability. Local mobility means that the lumbar spine and its adjacent regions possess adequate nerve and joint(s) mobility and soft tissue compliance (ie, the malleability of tissue to undergo elastic deformation)...
December 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29993214/relationship-between-otological-symptoms-and-tmd
#4
Pamela Maria Kusdra, Jose Stechman-Neto, Bianca Lopes Cavalcante de Leão, Paulo Francisco Arant Martins, Adriana Bender Moreira de Lacerda, Bianca Simone Zeigelboim
BACKGROUND: Patients with any type of temporomandibular disorder (TMD) may have several symptoms in their temporomandibular joints, masticatory muscles and associated structures, and may have otological symptoms such as tinnitus, ear fullness, ear pain, hearing loss, hyperacusis, and vertigo, which may be due to the anatomical proximity between the temporomandibular joint, muscles innervated by the trigeminal nerve, and ear structures. Objective: This study found a prevalence of ear complaints described in the medical records of patients (n = 485) at the Center for Diagnosis and Treatment of the Temporomandibular Joint and Dental-Facial Functional Alterations at Tuiuti University of Paraná (CDATM/UTP), with TMD evaluated by the Research Diagnostic Criteria/Temporomandibular Disorders (RDC/ TMD)...
June 1, 2018: International Tinnitus Journal
https://www.readbyqxmd.com/read/29958917/synovial-nerve-fiber-density-decreases-with-naturally-occurring-osteoarthritis-in-horses
#5
Raymond Pujol, Christiane A Girard, Hélène Richard, Ida Hassanpour, Marie Pier Binette, Guy Beauchamp, Jason J McDougall, Sheila Laverty
OBJECTIVE: To measure the nerve fiber density in synovial membranes from healthy and OA equine joints and to investigate the relationship between synovial innervation and OA severity, synovial vascularity and synovitis. DESIGN: Twenty-five equine metacarpophalangeal joints were collected post-mortem. The joints were dissected and the macroscopic lesions of the articular cartilage were scored. Synovial membrane specimens (n=50) were harvested, fixed, sectioned and scored histologically...
June 26, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29950908/percutaneous-direct-current-stimulation-a-new-electroceutical-solution-for-severe-neurological-pain-and-soft-tissue-injuries
#6
Albrecht Molsberger, Colin D McCaig
There is a high medical need to improve the effectiveness of the treatment of pain and traumatic soft tissue injuries. In this context, electrostimulating devices have been used with only sporadic success. There is also much evidence of endogenous electrical signals that play key roles in regulating the development and regeneration of many tissues. Transepithelial potential gradients are one source of the direct current (DC) electrical signals that stimulate and guide the migration of inflammatory cells, epithelial cells, fibroblasts and mesenchymal stem cells to achieve effective wound healing...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29945400/-precise-application-of-traditional-chinese-medicine-in-minimally-invasive-techniques
#7
Fu-Hui Dong
The miminally-invasive techniques of traditional Chinese medicine(TCM) uses different types of acupuncture needles to treat diseased locations with special techniques. These techniques include different methods of insertion and closed incision (press cutting, sliding cutting, scrape cutting, etc.). This needling technique is based on the traditional Chinese medicine theories of Pi Bu (cutaneous), Jing Jin (sinew), Jing Luo (meridian), Wu Ti (five body structure components) and Zang Fu (organ system). Commonly used needles include: needle Dao , needle with edge, Pi needle, Shui needle, Ren needle, Gou needle, Chang Yuan needle, Bo needle and so on...
June 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29933094/phenol-neurolysis-for-management-of-shoulder-spasticity-in-early-recovery-from-traumatic-brain-injury-a-case-report
#8
Manuel F Mas, Craig DiTommaso, Sheng Li
This case describes a 16-year-old boy who suffered a severe traumatic brain injury. The patient gradually recovered but developed debilitating spasticity mainly in left triceps muscle, abnormal positioning of shoulder girdle complex, and shoulder pain. Phenol (6%) was injected to axillary and radial nerves under guidance of electrical stimulation and ultrasound imaging at 10 weeks after initial injury. After injection, triceps spasticity and shoulder pain was immediately reduced and abnormal positions of shoulder girdle complex and elbow joint gradually returned to functional limits over 2 weeks...
June 19, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29913629/new-objective-findings-after-whiplash-injuries-high-blood-flow-in-painful-cervical-soft-tissue-an-ultrasound-pilot-study
#9
Hatem Kalawy, Britt-Marie Stålnacke, Martin Fahlström, Lars Öhberg, Felix Linetsky, Håkan Alfredson
Background The presence of high blood flow in the structurally abnormal and painful regions of tendinosis, but not in the normal pain-free tendons, was recently confirmed by colour Doppler (CD) ultrasound (US). Biopsies from the regions with high blood flow demonstrated the presence of sympathetic and sensitive nerve fibres juxtapositioned to neovessels. Grey-scale US and CD are reliable methods used to evaluate structural homogeneity, thickness, and blood flow in the peripheral tendons. The aim of this study was to utilize CD to qualitatively evaluate for the presence of abnormal high blood flow in paravertebral tissues after whiplash injuries in patients with chronic neck pain...
October 1, 2013: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29876592/ganglion-cyst-arising-from-the-transverse-acetabular-ligament-tal-a-rare-cause-of-entrapment-of-the-anterior-branch-of-the-obturator-nerve-case-report-and-review-of-the-literature
#10
Alessandro Vidoni, Satyanarayana T V Sankara, Venkata Ramana, Rajesh Botchu
The transverse acetabular ligament is an unusual location for ganglion cysts. Only a few cases have been reported in the literature. They can be asymptomatic and represent an incidental finding or can cause an atypical pattern of hip joint/groin pain. We report a case of ganglion cyst arising from the TAL causing entrapment of the anterior branch of the obturator nerve with associated acute denervation of the abductor longus (AL), adductor brevis (AB), and gracilis muscles.
June 6, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29750024/locomotive-syndrome-clinical-perspectives
#11
Tatsunori Ikemoto, Young-Chang Arai
The deterioration of locomotive components, which comprise bones, joints, and intervertebral discs, and muscles and nerves, can lead to symptoms such as pain, limitations in the range of joint mobility, malalignment, impaired balance, and difficulty walking. Locomotive syndrome (LoS) was proposed by the Japanese Orthopedic Association in 2007 as a concept for people who are at a high risk of developing a musculoskeletal ambulation disability attributed to locomotor organs. Although many international articles related to LoS have been published, an international consensus of this concept seems to be lacking...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29666775/thenar-compartment-syndrome-what-if-a-compartment-pressure-measuring-device-is-absent
#12
Aydin Budeyri, Mehmet C Cankus, Gökhan Meric, Gökhan B Sever
Compartment syndrome (CS) is a threatening condition characterized by excessive tissue pressure accumulation associated with acute trauma. Compartment syndrome causes a significant reduction in blood flow with subsequent muscle and nerve ischemic necrosis. Recently, reports have described the importance of intramuscular pressure measurements as a basis for CS diagnosis. Unfortunately, the measuring devices that were utilized produced results with unsatisfactory reliability, making a diagnosis and subsequent treatment challenging...
February 16, 2018: Curēus
https://www.readbyqxmd.com/read/29649527/recommendations-for-evaluation-and-management-of-pain-in-patients-with-mucopolysaccharidosis-in-latin-america
#13
Juan M Politei, Gisel Gordillo-González, Norberto B Guelbert, Carolina F Moura de Souza, Charles M Lourenço, Martha L Solano, Mariana M Junqueira, Tatiana S P C Magalhães, Ana M Martins
The mucopolysaccharidosis (MPS) constitutes a heterogeneous group of rare genetic disorders caused by enzymatic deficiencies that lead to the accumulation of glycosaminoglycans. Several types of MPS are described, historically numbered from I to IX. Clinical observations strongly suggest the presence of chronic pain in patients with all types of MPS. There are few data in the literature on the evaluation and management of pain in these patients, a fact that can compromise the quality of life even more. Professionals with extensive experience in the care for patients with MPS held a meeting in April 2017 to discuss and propose recommendations for the evaluation and management of pain in patients with MPS in Latin America...
July 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29643577/effects-of-concentric-contraction-of-the-wrists-and-transcutaneous-electrical-nerve-stimulation-cycle-on-pain-and-muscle-strength-in-lateralepicondylitis-patients
#14
Yeong-Deok Choi, Myung-Joon Kim, Jung-Ho Lee
[Purpose] This study examined the effects of transcutaneous electrical nerve stimulation and concentric contraction of the muscles surrounding the elbow joints on pain and muscular strength in the elbow joints of patients with lateral epicondylitis. [Subjects and Methods] The subjects of this study were 30 patients who visited our hospital with the main complaint of lateral pain in the elbow joint. All subjects were randomly and equally assigned to an experimental group that conducted concentric contraction exercises in sync with a transcutaneous electrical nerve stimulation cycle and a control group that performed concentric contraction after the application of transcutaneous electrical nerve stimulation...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29614328/recommendations-for-evaluation-and-management-of-pain-in-patients-with-mucopolysaccharidosis-in-latin-america
#15
J M Politei, G Gordillo-González, N Guelbert, C F M Souza, C M Lourenço, M L Solano, M M Junqueira, T S P C Magalhães, A M Martins
The mucopolysaccharidosis (MPS) constitute a heterogeneous group of rare genetic disorders caused by enzymatic deficiencies that lead to the accumulation of glycosaminoglycans (GAGs). Several types of MPS are described, historically numbered from I to IX. Clinical observations strongly suggest the presence of chronic pain in patients with all types of MPS. There are few data in the literature on the evaluation and management of pain in these patients, a fact which can compromise the quality of life even more...
March 31, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29608038/physical-therapy-needs-for-patients-with-physical-function-injuries-post-earthquake-disasters-a-systematic-review-of-chinese-and-western-literature
#16
Hao Li, John Nyland, Katrina Kuban, Justin Givens
BACKGROUND AND PURPOSE: Over the last 500 years, the most earthquakes with 10,000 or more fatalities and the most overall fatalities have occurred in China. Physical therapists must develop a better understanding of the patient and injury types that they are likely to treat post-earthquake disasters. This systematic review of Chinese and Western literature identified the primary patients treated by physical therapists post-earthquake disasters for injuries that negatively impacted physical function, activity, and participation...
July 2018: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/29551375/prosthetic-rehabilitation-for-a-patient-treated-for-embryonal-rhabdomyosarcoma
#17
Korbinian Benz, Carla Kozmacs, Andree Piwowarczyk, Jochen Jackowski
A female patient, now aged 17 years, was diagnosed with rhabdomyosarcoma (RMS) in the right pterygopalatine fossa when she was 3 years old. The RMS was successfully treated by excision, but the subsequent radiation and polychemotherapy resulted in the complete anesthesia of the distribution area of the right trigeminal nerve and loss of vision in the right eye. The patient also experienced pain in the mandibular joints and masticatory muscles. Panoramic radiographs displayed a multiple agenesia of the permanent teeth and underdeveloped apices...
March 15, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29487784/pectoralis-major-muscle-transfer-with-the-sternal-head-and-hamstring-autograft-for-scapular-winging
#18
Antonio Cusano, Nicholas Pagani, Xinning Li
Medial scapular winging is often due to dysfunction of the serratus anterior muscle as a result of injury to the long thoracic nerve. Impairment of the serratus anterior muscle may cause uncoordinated scapulohumeral rhythm during shoulder elevation and subsequent subscapular or shoulder pain, subacromial impingement, and glenohumeral joint instability. Although long thoracic nerve injury typically resolves in 12 to 18 months after a physical therapy regimen, surgical intervention is indicated in patients who fail conservative management...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29349988/-comparison-of-analgesic-effects-between-multimodal-and-patient-controlled-intravenous-analgesia-in-patients-with-rheumatoid-arthritis-in-the-perioperative-period-of-total-knee-arthroplasty
#19
RANDOMIZED CONTROLLED TRIAL
Hua-Li Gao, Lian-Bo Xiao, Wei-Tao Zhai, Yong He, Fei Zhu, Lin Zheng, Xiu-Wei Han
OBJECTIVE: To compare the analgesic effect between multimodal and patient-controlled intravenous analgesia(PCIA) in patients with rheumatoid arthritis(RA) in the perioperative period of knee joint replacement. METHODS: From June 2015 to June 2016, 40 RA patients undergoing total knee arthroplasty were randomly divided into two groups. There were 20 patients in PCIA group, including 3 males and 17 females, with an average age of(59.6±2.3) years old, who received controlled instillation of sufentanil analgesia controlled by an intravenous analgesia pump...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29320549/assessing-adverse-effects-of-intra-articular-botulinum-toxin-a-in-healthy-beagle-dogs-a-placebo-controlled-blinded-randomized-trial
#20
RANDOMIZED CONTROLLED TRIAL
Helka M Heikkilä, Tarja S Jokinen, Pernilla Syrjä, Jouni Junnila, Anna Hielm-Björkman, Outi Laitinen-Vapaavuori
OBJECTIVE: To investigate the clinical, cytological, and histopathological adverse effects of intra-articularly injected botulinum toxin A in dogs and to study whether the toxin spreads from the joint after the injection. METHODS: A longitudinal, placebo-controlled, randomized clinical trial was conducted with six healthy laboratory Beagle dogs. Stifle joints were randomized to receive either 30 IU of onabotulinum toxin A or placebo in a 1:1 ratio. Adverse effects and spread of the toxin were examined by evaluating dynamic and static weight-bearing of the injected limbs, by assessing painless range of motion and pain on palpation of joints, and by performing synovial fluid analysis, neurological examination, and electrophysiological recordings at different examination time-points in a 12-week period after the injections...
2018: PloS One
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