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Long noncoding rna

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https://www.readbyqxmd.com/read/28654795/low-expression-of-long-noncoding-rna-casc2-indicates-a-poor-prognosis-and-promotes-tumorigenesis-in-thyroid-carcinoma
#1
Xiangqing Xiong, Hua Zhu, Xiangjian Chen
Recently, long noncoding RNAs (lncRNAs) have been shown to be linked to regulate different biological processes, such as cell growth, differentiation and tumorigenesis. LncRNAs have been identified to be promising clinical biomarkers in various tumors. Long noncoding RNAs cancer susceptibility candidate 2 (CASC2) has recently been demonstrated to be correlated to tumorigenesis in renal cell carcinoma, lung carcinoma, glioma, and gastric carcinoma. Nevertheless, the research on the biological function and clinical significance of CASC2 in thyroid carcinoma are still unclear...
June 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28654727/using-the-noncode-database-resource
#2
Li Xiyuan, Bu Dechao, Sun Liang, Wu Yang, Fang Shuangsang, Li Hui, Luo Haitao, Luo Chunlong, Fang Wenzheng, Chen Runsheng, Zhao Yi
NONCODE is a comprehensive database that aims to present the most complete collection and annotation of non-coding RNAs, especially long non-coding RNAs (lncRNA genes), and thus NONCODE is essential to modern biological and medical research. Scientists are producing a flood of new data from which new lncRNA genes and lncRNA-disease relationships are continually being identified. NONCODE assimilates such information from a wide variety of sources including published articles, RNA-seq data, micro-array data and databases on genetic variation (dbSNP) and genome-wide associations (GWAS)...
June 27, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28653903/biological-function-of-long-noncoding-rna-snar-in-her2-positive-breast-cancer-cells
#3
Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Soo Jung Lee, Jae-Hwan Jeong, Seung Hee Kang, Jin Hyang Jung, Yee Soo Chae
PURPOSE: Long noncoding RNA, snaR (small NF90-associated RNA), has been reported to be upregulated in various cancer cell lines. We evaluated the additional role of snaR in HER2-positive breast cancer cell lines. METHODS: We explored changes of expression of snaR among the selected long noncoding RNAs which have a potential in cancer proliferation or progression. The proliferation, migration, and invasion of HER2-positive breast cancer cells (SK-BR3) were evaluated by snaR with RNA interruption in 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, wound-healing assay, and Transwell assay...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28653781/differential-expression-profile-of-long-non-coding-rna-in-cardiomyocytes-autophagy-induced-by-angiotensin-ii
#4
Ying Gu, Fan Yang, Ru-Ming Xu, Yun-Yan Zhang, Yang Li, Su-Xuan Liu, Guan-Xin Zhang, Guo-Kun Wang, Li-Ping Ma
Autophagy is a ubiquitous intracellular process for cellular homeostasis maintainance by recycling damaged protein and organelles. Dysregulation of cardiomyocytes autophagic activity is implicated in various heart diseases. Recent studies had demonstrated long non-coding RNAs (lncRNAs) played crucial roles on modulation of autophagic activity. In this study, we first established an angiotensin II-induced autophagy model on neonatal rat cardiomyocytes. Western blot assay confirmed that the expression of Beclin 1 and the conversion of soluble LC3-I to lipid bound LC3-II were significantly increased at 12h after angiotensin II stimulation, but the cardiomyocytes surface area and hypertrophic markers expression had no significant change...
June 27, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28653111/seed-weight-differences-between-wild-and-domesticated-soybeans-are-associated-with-specific-changes-in-gene-expression
#5
Chao Yu, Zhipeng Qu, Yueting Zhang, Xifeng Zhang, Tingting Lan, David L Adelson, Dong Wang, Youlin Zhu
Our study systematically explored potential genes and molecular pathways as candidates for differences in seed weight resulting from soybean domestication. In addition, potential contributions of lncRNAs to seed weight were also investigated. Soybeans have a long history of domestication in China, and there are several significant phenotypic differences between cultivated and wild soybeans, for example, seeds of cultivars are generally larger and heavier than those from wild accessions. We analyzed seed transcriptomes from thirteen soybean samples, including six landraces and seven wild accessions using strand-specific RNA sequencing...
June 26, 2017: Plant Cell Reports
https://www.readbyqxmd.com/read/28652859/lncrna-h19-promotes-the-differentiation-of-bovine-skeletal-muscle-satellite-cells-by-suppressing-sirt1-foxo1
#6
Xiaochun Xu, Shengyue Ji, Weili Li, Bao Yi, Hengxin Li, Hongfu Zhang, Wenping Ma
BACKGROUND: H19 is a well-characterized Long noncoding RNA (lncRNA) that has been proven to promote myoblast differentiation in humans and mice. However, its mechanism of action is still not fully interpreted. METHODS: Using RT-qPCR, we examined H19 RNA levels in various tissues from 1-week, 1-month, 6-month and 36-month old male cattle (i.e., newborn, infant, young and adult). The protein and mRNA levels of MyoG, MyHC, Sirt1 and FoxO1 in the satellite and C2C12 cells with an H19 silencing or overexpression vector were respectively detected using western blot and real-time qPCR...
2017: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/28652769/upregulated-long-noncoding-rna-pandar-predicts-an-unfavorable-prognosis-and-promotes-tumorigenesis-in-cholangiocarcinoma
#7
Yi Xu, Xingming Jiang, Yunfu Cui
Cholangiocarcinoma (CCA) is one of the most malignant human cancers with increasing incidence worldwide. LncRNAs have emerged as gene regulators and prognostic biomarkers in a variety of neoplasms. PANDAR, a novel cancer-related lncRNA, has been reported to be upregulated in diverse human carcinomas. In this study, we aimed to investigate the clinical significance of lncRNA PANDAR in CCA and explore its functional roles in CCA cells including cell proliferation, apoptosis, migration, invasion and epithelial-to-mesenchymal transition (EMT)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652763/letter-to-the-editor-regarding-the-article-prognostic-role-of-long-noncoding-rna-neat1-in-various-carcinomas-a-meta-analysis
#8
COMMENT
He Yu, Peng Wang, Xiong Zhang
No abstract text is available yet for this article.
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28648755/high-expression-of-long-noncoding-rna-malat1-indicates-a-poor-prognosis-and-promotes-clinical-progression-and-metastasis-in%C3%A2-bladder-cancer
#9
Chao Li, Yu Cui, Long-Fei Liu, Wen-Biao Ren, Qia-Qia Li, Xu Zhou, Yang-Le Li, Yang Li, Xiang-Yang Bai, Xiong-Bing Zu
BACKGROUND: Recent studies have demonstrated that the expression of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotes cancer cell proliferation, invasion, and metastasis in many tumor types, but the association between bladder cancer and MALAT1 remains unknown. MATERIALS: The expression of MALAT1 was tested by in situ hybridization (ISH) in 120 bladder cancer specimens. The association between MALAT1 expression and clinicopathological features and prognosis of the patients with bladder cancer was analyzed...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28645110/long-noncoding-rna-ccat2-as-a-novel-biomaker-of-metastasis-and-prognosis-in-human-cancer-a-meta-analysis
#10
REVIEW
Dailian Wang, Zhicong Chen, Haidan Xu, Anbang He, Yuchen Liu, Weiren Huang
Colon cancer-associated transcript2 (CCAT2), a long noncoding RNA (LncRNA), has been found to function as an oncogene in various cancers. However, the clinical value of CCAT2 in cancers remains unclear. Therefore, we performed this meta-analysis to investigate the association between CCAT2 level and metastasis & prognosis in malignant tumors. The meta analysis was performed by using a systematic search in PubMed, Web of Science, and Cochrane Library from inception to NOV 17, 2016. According to the inclusion and exclusion criteria,9 studies with 1084 patients were included in the meta-analysis...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28644958/translating-cancer-epigenomics-into-the-clinic-focus-on-lung-cancer
#11
REVIEW
Josep Mari-Alexandre, Angel Diaz-Lagares, Maria Villalba, Oscar Juan, Ana B Crujeiras, Alfonso Calvo, Juan Sandoval
Epigenetic deregulation is increasingly being recognized as a hallmark of cancer. Recent studies have identified many new epigenetic biomarkers, some of which are being introduced into clinical practice for diagnosis, molecular classification, prognosis or prediction of response to therapies. O-6-methylguanine-DNA methyltransferase gene is the most clinically advanced epigenetic biomarker as it predicts the response to temozolomide and carmustine in gliomas. Therefore, epigenomics may represent a novel and promising tool for precision medicine, and in particular, the detection of epigenomic biomarkers in liquid biopsies will be of great interest for monitoring diseases in patients...
June 2, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28641698/-expression-of-serum-lncrna-hotair-in-non-small-cell-lung-cancer-%C3%A2-and-its-clinical-significance
#12
Nan Tan, Lihong Li, Lu Bai, Kun Zhao
BACKGROUND: The expression of long noncoding RNA HOX antisense RNA (HOTAIR) is abnormal in a variety of tumors. The aim of this study is to explore the serum levels and clinical significance of HOTAIR in patients with non-small cell lung cancer (NSCLC). METHODS: The serum levels of HOTAIR were detected by real-time quantitative polymerase chain reaction (PCR) in 64 NSCLC patients and 64 normal controls. The relationships between the serum levels of HOTAIR and clinical pathological parameters were analyzed...
June 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28640079/a-genome-wide-association-scan-of-biological-processes-involved-in-oral-lichen-planus-and-oral-squamous-cell-carcinoma
#13
Qiaozhen Yang, Beiyun Xu, Hongying Sun, Xiaxia Wang, Jie Zhang, Xuedi Yu, Xiaojuan Ma
BACKGROUND: In this study, the molecular mechanisms underlying malignant transformation from oral lichen planus (OLP) to oral squamous cell carcinoma (OSCC) were examined. METHODS: High-throughput sequencing of long noncoding RNAs (lncRNAs) and mRNAs of normal subjects and patients with OLP and OSCC was conducted. RNA-seq reads were mapped, lncRNA and mRNA transcripts were assembled, and expression levels were estimated. The targets of lncRNAs were predicted. Finally, Gene Ontology (GO) and pathway enrichment analyses of differentially expressed genes (DEGs) and lncRNA targets were performed...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639619/long-noncoding-rna-lnchifcar-mir31hg-is-a-hif-1%C3%AE-co-activator-driving-oral-cancer-progression
#14
Jing-Wen Shih, Wei-Fan Chiang, Alexander T H Wu, Ming-Heng Wu, Ling-Yu Wang, Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A Changou, Yun Yen, Hsing-Jien Kung
Long noncoding RNAs (lncRNAs) have been implicated in hypoxia/HIF-1-associated cancer progression through largely unknown mechanisms. Here we identify MIR31HG as a hypoxia-inducible lncRNA and therefore we name it LncHIFCAR (long noncoding HIF-1α co-activating RNA); we describe its oncogenic role as a HIF-1α co-activator that regulates the HIF-1 transcriptional network, crucial for cancer development. Extensive analyses of clinical data indicate LncHIFCAR level is substantially upregulated in oral carcinoma, significantly associated with poor clinical outcomes and representing an independent prognostic predictor...
June 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28638716/long-noncoding-rna-expression-in-peripheral-blood-mononuclear-cells-and-suicide-risk-in-chinese-patients-with-major-depressive-disorder
#15
Xuelian Cui, Wei Niu, Lingming Kong, Mingjun He, Kunhong Jiang, Shengdong Chen, Aifang Zhong, Wanshuai Li, Jim Lu, Liyi Zhang
BACKGROUND: WHO stated that nearly one million people commit suicide every year worldly, and 40% of the suicide completer suffered from depression. The primary aim of this study was to explore the association between long noncoding RNAs (lncRNAs) expression in peripheral blood mononuclear cells (PBMCs) and suicide risk of patients with major depressive disorder (MDD). METHODS: Using Human LncRNA 3.0 microarray profiling which includes 30,586 human lncRNAs and RT-PCR, six down-regulated lncRNAs were identified differentially expressed in MDD patients...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638466/long-noncoding-rna-ccat2-as-a-potential-novel-biomarker-to-predict-the-clinical-outcome-of-cancer-patients-a-meta-analysis
#16
Juan Tan, Yi-Chao Hou, Lin-Na Fu, Yun-Qian Wang, Qian-Qian Liu, Hua Xiong, Ying-Xuan Chen, Jing-Yuan Fang
Background: Colon Cancer-Associated Transcript 2 (CCAT2) has been demonstrated associated with clinical outcomes in various tumors. However, the results from each study were unfortunately insufficient and not completely consistent. Therefore, we conduct a systematic meta-analysis to evaluate the value for a feasible biomarker for metastasis and prognosis. Methods: A meta-analysis was performed using data obtained through a systematic search of PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wanfang database and VIP database...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28637928/the-long-noncoding-rna-wisper-controls-cardiac-fibrosis-and-remodeling
#17
Rudi Micheletti, Isabelle Plaisance, Brian J Abraham, Alexandre Sarre, Ching-Chia Ting, Michael Alexanian, Daniel Maric, Damien Maison, Mohamed Nemir, Richard A Young, Blanche Schroen, Arantxa González, Samir Ounzain, Thierry Pedrazzini
Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac development and disease. However, our understanding of the importance of these molecules in cardiac fibrosis is limited. Using an integrated genomic screen, we identified Wisper (Wisp2 super-enhancer-associated RNA) as a cardiac fibroblast-enriched lncRNA that regulates cardiac fibrosis after injury. Wisper expression was correlated with cardiac fibrosis both in a murine model of myocardial infarction (MI) and in heart tissue from human patients suffering from aortic stenosis...
June 21, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28637169/novel-molecules-lncrnas-trfs-and-circrnas-deciphered-from-next-generation-sequencing-rna-sequencing-computational-databases-and-tools
#18
A Saleembhasha, Seema Mishra
Powerful next-generation sequencing (NGS) technologies, more specifically RNA sequencing (RNA-seq), have been pivotal toward the detection and analysis and hypotheses generation of novel biomolecules, long noncoding RNAs (lncRNAs), tRNA-derived fragments (tRFs) and circular RNAs (circRNAs). Experimental validation of the occurrence of these biomolecules inside the cell has been reported. Their differential expression and functionally important role in several cancers types as well as other diseases such as Alzheimer's and cardiovascular diseases have garnered interest toward further studies in this research arena...
June 20, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28635400/the-long-noncoding-rna-foxcut-promotes-proliferation-and-migration-by-targeting-foxc1-in-nasopharyngeal-carcinoma
#19
Yu-Zhong Xu, Fang-Fang Chen, Yu Zhang, Qin-Fei Zhao, Xiao-Long Guan, Hai-Yong Wang, Ang Li, Xin Lv, Shu-Sheng Song, Ying Zhou, Xiao-Jun Li
Long noncoding RNAs play an important role in various biological processes, including tumorigenesis. FOXC1 (Forkhead box C1) is a member of the Forkhead box family of transcription factors and plays a crucial role in nasopharyngeal carcinoma. In this study, a novel long noncoding RNA (FOXCUT) located upstream of FOXC1 was investigated in 42 nasopharyngeal carcinoma patients. Our analysis revealed that the expression levels of FOXCUT and FOXC1 in nasopharyngeal carcinoma tissues were significantly higher than those observed in chronic nasopharyngitis tissues and that FOXCUT expression was positively correlated with FOXC1 expression...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28635106/long-noncoding-rna-and-its-contribution-to-autism-spectrum-disorders
#20
REVIEW
Jie Tang, Yizhen Yu, Wei Yang
Recent studies have indicated that long noncoding RNAs (lncRNAs) play important roles in multiple processes, such as epigenetic regulation, gene expression regulation, development, nutrition-related and other diseases, toxic response, and response to drugs. Although the functional roles and mechanisms of several lncRNAs have been discovered, a better understanding of the vast majority of lncRNAs remains elusive. To understand the functional roles and mechanisms of lncRNAs is critical because these transcripts represent the majority of the transcriptional output of the mammalian genome...
June 20, 2017: CNS Neuroscience & Therapeutics
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