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Long noncoding rna

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https://www.readbyqxmd.com/read/29456985/evaluation-of-mir-21-inhibition-and-its-impact-on-cancer-susceptibility-candidate-2-long-noncoding-rna-in-colorectal-cancer-cell-line
#1
Miganoosh Simonian, Mohammadreza Sharifi, Reza Nedaeinia, Meysam Mosallaie, Sharifeh Khosravi, Amir Avan, Majid Ghayour-Mobarhan, Hadi Bagheri, Rasoul Salehi
Background: Both microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have been shown to have a critical role in the regulation of cellular processes such as cell growth and apoptosis, as well as cancer progression and metastasis. lncRNAs are aberrantly expressed in many diseases including cancer. Although it is well known that miRNAs can target a large number of protein-coding genes, little is known whether miRNAs can also target lncRNAs. In the present study, we determine whether miR-21 can regulate lncRNA cancer susceptibility candidate 2 (CASC2) in colorectal cancer...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456724/long-noncoding-rna-blacat1-promotes-cell-proliferation-and-invasion-in-human-cervical-cancer
#2
Dan Shan, Yumin Shang, Tongxiu Hu
Cervical cancer is one of the leading causes of mortality in females worldwide. Predisposition to distant metastasis has reduced the prognosis of this malignancy, thus the identification of a novel agent for metastatic cervical cancer is required. Long noncoding RNAs (LncRNAs) have been reported to serve significant roles in human tumorigenesis. The present study aimed to investigate the effects of a newly discovered LncRNA bladder cancer associated transcript 1 (non-protein coding) (BLACAT1) on cell proliferation and metastasis in cervical cancer...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29453409/a-potential-prognostic-long-noncoding-rna-signature-to-predict-recurrence-among-er-positive-breast-cancer-patients-treated-with-tamoxifen
#3
Kang Wang, Jie Li, Yong-Fu Xiong, Zhen Zeng, Xiang Zhang, Hong-Yuan Li
Limited predictable long noncoding RNA (lncRNA) signature was reported in tamoxifen resistance among estrogen receptor (ER)-positive breast cancer (BC) patients. The aim of this study was to identify and assess prognostic lncRNA signature to predict recurrence among ER-positive BC patients treated with tamoxifen. Cohorts from Gene Expression Omnibus (GEO) (n = 298) and The Cancer Genome Atlas (TCGA) (n = 160) were defined as training and validation cohort, respectively. BC relapse associated lnRNAs was identify within training cohort, and the predictable value of recurrence was assessed in both cohorts...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452232/long-noncoding-rna-pvt1-promotes-emt-via-mediating-microrna-186-targeting-of-twist1-in-prostate-cancer
#4
Zhongwen Chang, Jun Cui, Yongsheng Song
The pathogenesis and the underlying mechanism of endothelial-mesenchymal transition in prostate cancer remain unclear. Plasmacytoma variant translocation 1 (PVT1), a novel long non-coding RNA maps to 8q24.21, and in many tumor studies the up-regulation of PVT1 has already been reported. PVT1 is closely related to tumor cell proliferation, invasion, and metastasis. In this study, we employed a combination of techniques to study the role of PVT1 in prostate cancer, which included bioinformatic analysis, Western blotting and cell migration assays of prostate cancer cell lines...
February 13, 2018: Gene
https://www.readbyqxmd.com/read/29449541/long-noncoding-rna-meg3-suppresses-liver-cancer-cells-growth-through-inhibiting-%C3%AE-catenin-by-activating-pkm2-and-inactivating-pten
#5
Qidi Zheng, Zhuojia Lin, Jie Xu, Yanan Lu, Qiuyu Meng, Chen Wang, Yuxin Yang, Xiaoru Xin, Xiaonan Li, Hu Pu, Xin Gui, Tianming Li, Wujun Xiong, Dongdong Lu
Maternally expressed gene 3 (MEG3) encodes an lncRNA which is suggested to function as a tumor suppressor and has been showed to involve in a variety of cancers. Herein, our findings demonstrate that MEG3 inhibits the malignant progression of liver cancer cells in vitro and in vivo. Mechanistically, MEG3 promotes the expression and maturition of miR122 which targets PKM2. Therefore, MEG3 decreases the expression and nuclear location of PKM2 dependent on miR122. Furthermore, MEG3 also inhibits CyclinD1 and C-Myc via PKM2 in liver cancer cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29448258/altered-long-noncoding-rna-and-messenger-rna-expression-in-experimental-intracerebral-hemorrhage-a-preliminary-study
#6
Cui Hanjin, Liu Tao, Li Pengfei, Yang Ali, Zhou Huajun, Luo Jiekun, Wang Yang, Tang Tao
BACKGROUND/AIMS: Functional recovery in the chronic phase is a difficult problem in intracerebral hemorrhage (ICH) treatment. Long noncoding RNAs (lncRNAs) are demonstrated to be involved in central nervous system (CNS) disorders. However, the roles of lncRNAs in post-ICH injury and repair are poorly understood, especially those that may be attributed to long-term neurological deficit. The present study depicted the lncRNA and messenger RNA (mRNA) profile by microarray at late stage after an experimental ICH...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29445179/long-noncoding-rna-gas5-promotes-bladder-cancer-cells-apoptosis-through-inhibiting-ezh2-transcription
#7
Miao Wang, Chen Guo, Liang Wang, Gang Luo, Chao Huang, Yawei Li, Dong Liu, Fuqing Zeng, Guosong Jiang, Xingyuan Xiao
Aberrant expression of long noncoding RNA GAS5 in bladder cancer (BC) cells was identified in recent studies. However, the regulatory functions and underlying molecular mechanisms of GAS5 in BC development remain unclear. Here, we confirmed that there was a negative correlation between GAS5 level and bladder tumor clinical stage. Functionally, overexpression of GAS5 reduced cell viability and induced cell apoptosis in T24 and EJ bladder cancer cells. Mechanistically, GAS5 effectively repressed EZH2 transcription by directly interacting with E2F4 and recruiting E2F4 to EZH2 promoter...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29444619/clinical-value-of-long-noncoding-rna-hotair-as-a-novel-biomarker-in-digestive-cancers-a-meta-analysis
#8
Yun Zhang, Yu Zhou, Tian Xu, Wei Tian, Chong Yang, Xiaoxiao Wang, Shan Zhong, Qin Ran, Hongji Yang, Shikai Zhu
HOX transcript antisense intergenic RNA has been reported to serve as an important prognostic biomarker in several types of cancers. However, the clinical value of HOX transcript antisense intergenic RNA in digestive cancers remains unclear. Therefore, we tried to investigate the clinical role of expression of HOX transcript antisense intergenic RNA as a prognostic indicator in digestive cancers by a meta-analysis. Literature collection was performed by searching the PubMed, Embase, Web of Science, and Cochrane Library databases (up to October 7, 2017)...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29443978/distinguishing-rna-modifications-from-noise-in-epitranscriptome-maps
#9
Anya V Grozhik, Samie R Jaffrey
Messenger RNA (mRNA) and long noncoding RNA (lncRNA) can be subjected to a variety of post-transcriptional modifications that markedly influence their fate and function. This concept of 'epitranscriptomic' modifications and the understanding of their function has been driven by new technologies for transcriptome-wide mapping of modified nucleotides using next-generation sequencing. Mapping technologies have successfully documented the location and prevalence of several modified nucleotides in the transcriptome...
February 14, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29441950/long-noncoding-rna-ccal-promotes-gastric-cancer-cell-proliferation-and-migration-in-a-myc-dependent-way
#10
Yuqiang Shan, Wencheng Kong, Akao Zhu, Panpan Yu, Qi Xie, Sixin Zheng, Huicheng Jin
AIMS: Long non-coding RNAs (lncRNAs) play key roles in cancers, yet their potential molecular mechanisms are not well understood. The objective of this study is to examine the expression, biological functions and mechanism of lncRNA CCAL in gastric cancer (GC). METHODS: MTT and Colony formation assay were used to detect cell proliferation and the colony formation ability of gastric cancer cells. Wound healing, Migration, and invasion assay were respectively used to explore the migration, and invasion in gastric cancer cell lines...
January 2, 2018: Die Pharmazie
https://www.readbyqxmd.com/read/29440295/microrna-203-inhibits-long-noncoding-rna-hotair-and-regulates-tumorigenesis-through-epithelial-to-mesenchymal-transition-pathway-in-renal-cell-carcinoma
#11
Pritha Dasgupta, Priyanka Kulkarni, Shahana Majid, Shahryari Varahram, Yutaka Hashimoto, Nadeem S Bhat, Marisa Shiina, Guoren Deng, Sharanjot Saini, Z Laura Tabatabai, Soichiro Yamamura, Yuichiro Tanaka, Rajvir Dahiya
This study aims to investigate the role of miR-203-HOTAIR interaction in the suppression of renal cell carcinoma (RCC). We employed series of in vitro assays such as proliferation, invasion, migration and colony formation along with in vivo tumor xenograft model. Profiling of miR-203 and HOTAIR expression revealed that miR-203 was significantly under-expressed whereas HOTAIR was overexpressed in RCC cell-lines and clinical specimens compared to normal cell line and tissue. Both miR-203 and HOTAIR expression significantly distinguished malignant from normal tissues and significantly correlated with clinicopathological characteristics of patients...
February 13, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29440232/noncoding-rnas-long-non-coding-rnas-and-micrornas-in-endocrine-related-cancers
#12
Carolyn M Klinge
The human genome is 'pervasively transcribed' leading to a complex array of non-coding RNAs (ncRNAs) that far outnumber coding mRNAs. ncRNAs have regulatory roles in transcription and post-transcriptional processes as well numerous cellular functions that remain to be fully described. Best characterized of the 'expanding universe' of ncRNAs are the ~ 22 nucleotide microRNAs (miRNAs) that base-pair to target mRNA's 3' untranslated region within the RNA-induced silencing complex (RISC) and block translation and may stimulate mRNA transcript degradation...
February 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29436635/differential-expression-profiles-of-long-noncoding-rna-and-mrna-in-colorectal-cancer-tissues-from-patients-with-lung-metastasis
#13
Ruo Shu, Yu Xu, Yan Tian, Yujian Zeng, Liang Sun, Fangyou Gong, Yi Lei, Kunhua Wang, Huayou Luo
Lungs are the most common extra‑abdominal site of metastasis of colorectal cancer (CRC), in which long noncoding RNA (lncRNA) may serve a role. In the present study, a high‑throughput microarray assay was performed to detect lncRNA expression and identify novel targets for further study of lung metastasis in CRC. In the CRC tissues from patients with lung metastasis, 7,632 lncRNA (3,574 upregulated and 4,058 downregulated) and 6,185 mRNA (3,394 upregulated and 2,791 downregulated) were detected to be differentially expressed with a fold change ≥2 and P<0...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436629/cognitive-improvement-following-ischemia-reperfusion-injury-induced-by-voluntary-running%C3%A2-wheel-exercise-is-associated-with-lncmalat1%C3%A2-mediated-apoptosis-inhibition
#14
Jin-Lin Shang, Qing Cheng, Sheng-Jie Duan, Lu Li, Li-Ya Jia
Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be associated with the functions and dysfunctions of endothelial cells. The present study investigated whether spontaneous running‑wheel (RW) exercise‑induced MALAT1 expression changes may be associated with the cognitive improvement of mice following I/R injury...
February 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29436579/long-noncoding-rna-ensrnog00000037522-is-involved-in-the-podocyte-epithelial%C3%A2-mesenchymal-transition-in-diabetic-rats
#15
Li Ling, Zhen Tan, Changning Zhang, Shuyan Gui, Yuanyuan Hu, Libo Chen
Diabetic nephropathy (DN) is one of the most common complications associated with type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, and recent evidence has demonstrated that they are involved in the process of the epithelial‑mesenchymal transition (EMT). In the present study, the potential functions of lncRNA ENSRNOG00000037522 during the EMT process in DN were investigated. The results identified that the level of the lncRNA ENSRNOG00000037522 was significantly increased in kidney tissues collected from rats with streptozocin (STZ)‑induced DN accompanied by impairment of the glomerular podocytes...
February 5, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29436491/long-non-coding-rna-linc00657-acting-as-mir-590-3p-sponge-to-facilitate-low-concentration-oxidized-low-density-lipoprotein-induced-angiogenesis
#16
Mei-Hua Bao, Guang-Yi Li, Xiao-Shan Huang, Liang Tang, Li-Ping Dong, Jian-Ming Li
Angiogenesis in atherosclerotic plaque promotes plaque growth, causes plaque hemorrhage and violates plaque stability. LINC00657 is a long noncoding RNA highly conserved and abundantly expressed in vascular endothelial cells. The present study was designed to investigate the effects and mechanisms of LINC00675 on the low concentration of oxidized low-density lipoprotein (oxLDL) induced angiogenesis. Cell proliferation assay, transwell assay, wound healing assay, and tube formation assay were conducted to detect the effects of low concentration of oxLDL on angiogenesis; The results discovered that oxLDL promoted the cell proliferation, migration, and tube formation...
February 7, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29436234/influence-of-hotair-rs920778-and-rs12826786-genetic-variants-on-prostate-cancer-risk-and-progression-free-survival
#17
Ana Isabel Oliveira, Ana Xavier-Magalhães, Catarina Moreira-Barbosa, Hugo Magalhães, Rui Henrique, Carmen Jerónimo, Bruno M Costa
AIM: Evaluate the impact of the single nucleotide polymorphisms rs920778 and rs12826786 in the long noncoding RNA HOTAIR in the susceptibility and prognosis of prostate cancer (PCa) patients. PATIENTS & METHODS: HOTAIR single nucleotide polymorphisms were genotyped by restriction fragment length polymorphism in 151 PCa cases and 180 cancer-free controls. Odds ratio, 95% CIs and prognostic significance were calculated. RESULTS: Our data showed no statistically significant associations between HOTAIR polymorphic variants in rs920778 and rs12826786 and PCa susceptibility...
February 13, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29435937/laser-capture-microdissection-of-epithelium-from-a%C3%A2-wound-healing-model-for-microrna-analysis
#18
Alyne Simões, Zujian Chen, Yan Zhao, Lin Chen, Virgilia Macias, Luisa A DiPietro, Xiaofeng Zhou
MicroRNAs are ~22 nucleotide-long noncoding RNAs influencing many cellular processes (including wound healing) by their regulatory functions on gene expression. The ability to analyze microRNA in different cells at the wound site is essential for understanding the critical role(s) of microRNA during various phases of wound healing. Laser capture micro-dissection (LCM) is an effective method to distinguish between relevant and non-relevant cells or tissues and enables the researcher to obtain homogeneous, ultra-pure samples from heterogeneous starting material...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29435112/lncrna-malat1-regulates-smooth-muscle-cell-phenotype-switch-via-activation-of-autophagy
#19
Tie-Feng Song, Li-Wen Huang, Ying Yuan, Hui-Qin Wang, Hong-Peng He, Wen-Jian Ma, Li-Hong Huo, Hao Zhou, Nan Wang, Tong-Cun Zhang
Vascular smooth muscle cells (VSMCs), switching from a differentiated to a proliferative phenotype, contribute to various vascular diseases. However, the role of long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 MALAT1 in the phenotype switching of VSMCs remains unclear. Here, we report that the knockdown of MALAT1 promotes the transformation of smooth muscle cells from a proliferative phenotype to a differentiated phenotype. MALAT1 knockdown inhibited cellular proliferation and migration, leading to significant cell cycle arrest in the G2 phase...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434890/meg3-inhibits-proliferation-and-invasion-and-promotes-apoptosis-of-human-osteosarcoma-cells
#20
Yao Shi, Chen Lv, Li Shi, Guanjun Tu
Osteosarcoma is known as a malignant tumour with a high mortality rate in orthopaedic settings; however, the factors associated with its degree of malignancy and the biological response remains to be elucidated. Although the essential role of the long noncoding RNA (lncRNA) maternally expressed 3 (MEG3) has been recently reported, its biological functions and regulatory mechanism in osteosarcoma cells have not yet been reported. In the present study, reverse transcription-quantitative polymerase chain reaction analysis revealed that the expression of MEG3 in MG63 cells was lower compared with in hFOB1...
February 2018: Oncology Letters
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