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Alzheimer's Dementia Sleep

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https://www.readbyqxmd.com/read/30104186/a-remote-intervention-to-prevent-or-delay-cognitive-impairment-in-older-adults-design-recruitment-and-baseline-characteristics-of-the-virtual-cognitive-health-vc-health-study
#1
Nicholas Bott, Shefali Kumar, Caitlyn Krebs, Jordan M Glenn, Erica N Madero, Jessie L Juusola
BACKGROUND: A growing body of evidence supports the use of lifestyle interventions for preventing or delaying the onset of Alzheimer disease and other forms of dementia in at-risk individuals. The development of internet-delivered programs would increase the scalability and reach of these interventions, but requires validation to ensure similar effectiveness to brick-and-mortar options. OBJECTIVE: We describe the study design, recruitment process, and baseline participant characteristics of the sample in the Virtual Cognitive Health (VC Health) study...
August 13, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/30083953/neuropsychiatric-symptoms-and-%C3%AE-synuclein-profile-of-patients-with-parkinson-s-disease-dementia-dementia-with-lewy-bodies-and-alzheimer-s-disease
#2
Anastasia Bougea, Leonidas Stefanis, George P Paraskevas, Evangelia Emmanouilidou, Efthimia Efthymiopoulou, Kostas Vekrelis, Elisabeth Kapaki
INTRODUCTION: Given the overlapping of neuropathological, neurochemical and neuropsychiatric profiles of Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), their differential diagnosis is challenging. Specific neuropsychiatric features or biomarkers, such as cerebrospinal fluid (CSF) α-Synuclein (α-Syn), may aid in differential diagnosis. This study aims to compare the neuropsychiatric and CSF α-Syn profiles in these conditions, and to investigate the possible association between CSF α-Syn levels and neuropsychiatric symptoms...
August 6, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30082497/-revised-2017-clinical-diagnostic-criteria-for-dementia-with-lewy-bodies-inclusion-of-rem-sleep-behavior-disorder-and-indicative-biomarkers
#3
Hiroshige Fujishiro
Although dementia with Lewy bodies (DLB) is the second most common neurodegenerative disorder after Alzheimer disease, its diagnostic sensitivity in clinical practice is sub-optimal. In 2017, the DLB clinical diagnostic criteria were modified to include the additional core feature of REM sleep behavior disorder (RBD) and three new indicative biomarkers. With this revision, clinically probable DLB is represented by two or more core features (fluctuations, parkinsonism, visual hallucinations, or RBD) or by one core feature plus one indicative biomarker (low striatal dopamine transporter uptake, reduced cardiac [<sup>123</sup>I]-metaiodobenzylguanidine uptake, or REM sleep without atonia on polysomnography)...
August 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/30073037/quality-of-life-in-patients-with-dementia-with-lewy-bodies
#4
REVIEW
Chuo-Yu Lee, Shih-Jung Cheng, Hui-Chi Lin, Yu-Lu Liao, Pei-Hao Chen
Dementia with Lewy bodies (DLB) is a complex, multisymptom disorder. When making decisions regarding the treatment of DLB, the patient's quality of life (QoL) should always be the main consideration. To our knowledge, this is the first review article focusing on the QoL in DLB patients. We searched the PubMed database using the keywords "quality of life" and "dementia with Lewy bodies." Previously, no specific instrument had been developed for assessing the QoL in DLB patients. Patients with DLB have a decreased QoL compared to patients with Alzheimer's disease, which is reportedly caused by several factors including level of independence in instrumental activities of daily living, whether the patient is living with the caregiver, apathy, delusion, and dysautonomia...
2018: Behavioural Neurology
https://www.readbyqxmd.com/read/30059136/use-of-body-sensors-to-examine-nocturnal-agitation-sleep-and-urinary-incontinence-in-individuals-with-alzheimer-s-disease
#5
Karen M Rose, John Lach, Yelena Perkhounkova, Jiaqi Gong, Sriram Raju Dandu, Robert Dickerson, Ifat Afrin Emi, Dawei Fan, Janet Specht, John Stankovic
Nighttime agitation, sleep disturbances, and urinary incontinence (UI) occur frequently in individuals with dementia and can add additional burden to family caregivers, although the co-occurrence of these symptoms is not well understood. The purpose of the current study was to determine the feasibility and acceptability of using passive body sensors in community-dwelling individuals with Alzheimer's disease (AD) by family caregivers and the correlates among these distressing symptoms. A single-group, descriptive design with convenience sampling of participants with AD and their family caregivers was undertaken to address the study aims...
August 1, 2018: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/30048891/deterioration-of-executive-dysfunction-in-elderly-with-rem-sleep-behavior-disorder-rbd
#6
Stefanie Lerche, Gerrit Machetanz, Benjamin Roeben, Isabel Wurster, Milan Zimmermann, Anna-Katharina von Thaler, Inga Liepelt-Scarfone, Gerhard W Eschweiler, Andreas Fallgatter, Florian Metzger, Walter Maetzler, Daniela Berg, Kathrin Brockmann
REM sleep behavior disorder (RBD) represents a major and relatively specific prodromal marker for synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies, and multisystem atrophy. Because PD patients primarily suffer from executive dysfunction, we hypothesized that individuals with RBD show an impairment in the nonamnestic executive domain rather than in amnestic domains. To address this question, we investigated a cohort of 1145 healthy elderly (183 with RBD) cross-sectionally and a subgroup of 544 of them longitudinally (144 with RBD) over 6 years...
June 30, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/30029715/multiple-chronic-conditions-implications-for-cognition-findings-from-the-wisconsin-registry-for-alzheimer-s-prevention-wrap
#7
Lisa C Bratzke, Beverly A Carlson, Chooza Moon, Roger L Brown, Rebecca L Koscik, Sterling C Johnson
INTRODUCTION: Several chronic illnesses have demonstrated relationships to cognitive decline in the context of aging. However, researchers have largely ignored the effects of multi-morbidity in the context of Alzheimer's disease and related dementias (ADRD) risk. The purpose of this study is to examine the relationship between multiple chronic conditions (MCC) and cognitive decline. METHODS: Latent class analysis (LCA) was completed to identify different subgroups of the 1285 participants from the Wisconsin Registry for Alzheimer's Prevention who were recognized based on their self-reported chronic illnesses...
August 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29953971/multimorbidity-is-associated-with-preclinical-alzheimer-s-disease-neuroimaging-biomarkers
#8
Aline Mendes, Sophie Tezenas du Montcel, Marcel Levy, Anne Bertrand, Marie-Odile Habert, Hugo Bertin, Bruno Dubois, Stéphane Epelbaum
BACKGROUND: Identifying comorbidities that influence preclinical Alzheimer's disease (AD) can give some insight into the AD early stages trajectories to allow new treatment venues and to guide public health systems to prevent subsequent dementia. OBJECTIVE: To examine the association of multimorbidity with AD neuroimaging markers in cognitively normal older adults. METHODS: This study had a cross-sectional design. Data regarding 14 comorbidities were obtained for all 318 adults aged 70-85 years, recruited from the community to an ongoing prospective monocentric cohort...
June 28, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29933746/why-could-meditation-practice-help-promote-mental-health-and-well-being-in-aging
#9
Gaël Chételat, Antoine Lutz, Eider Arenaza-Urquijo, Fabienne Collette, Olga Klimecki, Natalie Marchant
Psycho-affective states or traits such as stress, depression, anxiety and neuroticism are known to affect sleep, cognition and mental health and well-being in aging populations and to be associated with increased risk for Alzheimer's disease (AD). Mental training for stress reduction and emotional and attentional regulation through meditation practice might help reduce these adverse factors. So far, studies on the impact of meditation practice on brain and cognition in aging are scarce and have limitations but the findings are encouraging, showing a positive effect of meditation training on cognition, especially on attention and memory, and on brain structure and function especially in frontal and limbic structures and insula...
June 22, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29931147/the-self-care-needs-and-behaviors-of-dementia-informal-caregivers-a-systematic-review
#10
Kyra J Waligora, Mona N Bahouth, Hae-Ra Han
Background: More than 5.4 million informal caregivers (ICGs) in the United States care for persons with dementia (PWD). Failure of ICGs to incorporate self-care into their routine may lead to adverse health consequences. Caregivers and researchers need to understand the evidence around dementia ICGs' self-care practices. Purpose: To synthesize evidence on the self-care needs and behaviors of Alzheimer's and dementia ICGs and its research implications. Methods: PubMed, CINAHL, Scopus, and Web of Science were searched to conduct a systematic review of research...
June 21, 2018: Gerontologist
https://www.readbyqxmd.com/read/29898972/diffuse-lewy-body-disease-manifesting-as-corticobasal-syndrome-a-rare-form-of-lewy-body-disease
#11
Koji Kasanuki, Keith A Josephs, Tanis J Ferman, Melissa E Murray, Shunsuke Koga, Takuya Konno, Nobutaka Sakae, Adam Parks, Ryan J Uitti, Jay A Van Gerpen, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson
OBJECTIVE: To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS). METHODS: In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex...
July 17, 2018: Neurology
https://www.readbyqxmd.com/read/29886490/sleep-disturbance-and-the-risk-of-cognitive-decline-or-clinical-conversion-in-the-adni-cohort
#12
Adam P Mecca, Hannah R Michalak, Julia W McDonald, Emily C Kemp, Erika A Pugh, Melinda L Becker, Marcia C Mecca, Christopher H van Dyck
BACKGROUND: We investigated the relationship between sleep disturbance and cognitive decline or clinical conversion in individuals with normal cognition (CN), as well as those with mild cognitive impairment (MCI) and dementia due to Alzheimer disease (AD-dementia). METHODS: Secondary analysis of 1,629 adults between 48 and 91 years of age with up to 24 months of follow-up from the ADNI (Alzheimer's Disease Neuroimaging Initiative), a longitudinal cohort study. RESULTS: Sleep disturbance was not associated with decline in memory, executive function, or global cognition...
2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29873398/association-between-daily-sleep-duration-and-risk-of-dementia-and-mortality-in-a-japanese-community
#13
Tomoyuki Ohara, Takanori Honda, Jun Hata, Daigo Yoshida, Naoko Mukai, Yoichiro Hirakawa, Mao Shibata, Hiro Kishimoto, Takanari Kitazono, Shigenobu Kanba, Toshiharu Ninomiya
OBJECTIVES: To investigate the association between daily sleep duration and risk of dementia and death in a Japanese elderly population. DESIGN: Prospective cohort study. SETTING: The Hisayama Study, Japan. PARTICIPANTS: Community-dwelling Japanese individuals aged 60 and older without dementia. MEASUREMENTS: Self-reported daily sleep duration was grouped into 5 categories (<5.0, 5.0-6.9, 7...
June 6, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29865066/subjective-sleep-quality-is-not-associated-with-incident-dementia-the-rotterdam-study
#14
Thom S Lysen, Frank J Wolters, Annemarie I Luik, M Kamran Ikram, Henning Tiemeier, M Arfan Ikram
BACKGROUND: Poor sleep is related to higher dementia risk, but this association is more equivocal for subjective sleep quality specifically. This study investigates the link between subjective sleep quality and dementia risk in the general population. OBJECTIVE: To study the role of subjective sleep quality in the risk of dementia in the general population. METHODS: In the prospective population-based Rotterdam Study, 4,835 persons (mean age 72 years, 58% women) underwent a home interview (2002- 2006) that included the validated Pittsburgh Sleep Quality Index (PSQI) to assess sleep quality...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29862455/the-locus-coeruleus-neurotoxin-dsp4-and-or-a-high-sugar-diet-induce-behavioral-and-biochemical-alterations-in-wild-type-mice-consistent-with-alzheimers-related-pathology
#15
Pooja Choudhary, Anthony G Pacholko, Josh Palaschuk, Lane K Bekar
Alzheimer's disease (AD) is the sixth leading cause of death in the United States where it is estimated that one in three seniors dies with AD or another dementia. Are modern lifestyle habits a contributing factor? Increased carbohydrate (sugar) consumption, stress and disruption of sleep patterns are quickly becoming the norm rather than the exception. Interestingly, seven months on a non-invasive high sucrose diet (20% sucrose in drinking water) has been shown to induce behavioral, metabolic and pathological changes consistent with AD in wild-type mice...
June 3, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29734098/investigation-of-possible-risk-factors-for-depression-in-alzheimer-s-disease-a-systematic-review-of-the-evidence
#16
REVIEW
Natassa Steck, Claudia Cooper, Vasiliki Orgeta
BACKGROUND: Depression is common in people with Alzheimer's disease (AD), and is associated with increased risk of institutionalization and mortality. Understanding risk factors for depression in AD is key to its development and treatment. METHODS: We searched the MEDLINE, EMBASE, PsycINFO, and CINAL databases for longitudinal prospective cohort studies that evaluated risk factors for depression in people with AD. Two authors independently selected articles for inclusion and assessed quality of studies using predetermined criteria...
August 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29733807/fractal-regulation-and-incident-alzheimer-s-disease-in-elderly-individuals
#17
Peng Li, Lei Yu, Andrew S P Lim, Aron S Buchman, Frank A J L Scheer, Steven A Shea, Julie A Schneider, David A Bennett, Kun Hu
INTRODUCTION: Healthy physiological systems exhibit fractal regulation (FR), generating similar fluctuation patterns in physiological outputs across different time scales. FR in motor activity is degraded in dementia, and the degradation correlates to cognitive decline. We tested whether degraded FR predicts Alzheimer's dementia. METHODS: FR in motor activity was assessed in 1097 nondemented older adults at baseline. Cognition was assessed annually for up to 11 years...
May 4, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29719179/randomized-trial-of-verubecestat-for-mild-to-moderate-alzheimer-s-disease
#18
RANDOMIZED CONTROLLED TRIAL
Michael F Egan, James Kost, Pierre N Tariot, Paul S Aisen, Jeffrey L Cummings, Bruno Vellas, Cyrille Sur, Yuki Mukai, Tiffini Voss, Christine Furtek, Erin Mahoney, Lyn Harper Mozley, Rik Vandenberghe, Yi Mo, David Michelson
BACKGROUND: Alzheimer's disease is characterized by the deposition of amyloid-beta (Aβ) plaques in the brain. Aβ is produced from the sequential cleavage of amyloid precursor protein by β-site amyloid precursor protein-cleaving enzyme 1 (BACE-1) followed by γ-secretase. Verubecestat is an oral BACE-1 inhibitor that reduces the Aβ level in the cerebrospinal fluid of patients with Alzheimer's disease. METHODS: We conducted a randomized, double-blind, placebo-controlled, 78-week trial to evaluate verubecestat at doses of 12 mg and 40 mg per day, as compared with placebo, in patients who had a clinical diagnosis of mild-to-moderate Alzheimer's disease...
May 3, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29710716/brain-inflammation-connects-cognitive-and-non-cognitive-symptoms-in-alzheimer-s-disease
#19
M Clara Selles, Mauricio M Oliveira, Sergio T Ferreira
Alzheimer's disease (AD) is the main form of dementia in the elderly and affects greater than 47 million people worldwide. Care for AD patients poses very significant personal and economic demands on individuals and society, and the situation is expected to get even more dramatic in the coming decades unless effective treatments are found to halt the progression of the disease. Although AD is most commonly regarded as a disease of the memory, the entire brain is eventually affected by neuronal dysfunction or neurodegeneration, which brings about a host of other behavioral disturbances...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689719/the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#20
Alain D Dekker, Silvia Sacco, Angelo Carfi, Bessy Benejam, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, Mariángeles Boti, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Laura Checkley, André Strydom, Gert Van Goethem, Graziano Onder, Rafael Blesa, Christine Zu Eulenburg, Antonia M W Coppus, Anne-Sophie Rebillat, Juan Fortea, Peter P De Deyn
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated...
2018: Journal of Alzheimer's Disease: JAD
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