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Alzheimer's Dementia Sleep

Jessica E Manousakis, Anna J Scovelle, Shantha M W Rajaratnam, Sharon L Naismith, Clare Anderson
BACKGROUND: Increased sleep fragmentation and advanced circadian timing are hallmark phenotypes associated with increased age-related cognitive decline. Subjective cognitive decline (SCD) is considered a prodromal stage of neurodegeneration and dementia; however, little is known about how sleep and circadian timing impact on memory complaints in SCD. OBJECTIVE: To determine how sleep and circadian timing impact on memory complaint subtypes in older adults with SCD...
October 6, 2018: Journal of Alzheimer's Disease: JAD
Kim E Innes, Terry Kit Selfe, Kathleen Brundage, Caitlin Montgomery, Sijin Wen, Sahiti Kandati, Hannah Bowles, Dharma Singh Khalsa, Zenzi Huysmans
BACKGROUND: Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels have emerged as possible predictors of cognitive decline and dementia. OBJECTIVE: To assess the: 1) effects of two 12-week relaxation programs on TL, TA, and Aβ levels in adults with subjective cognitive decline; and 2) relationship of biomarker changes to those in cognitive function, psychosocial status, and quality of life (QOL). METHODS: Participants were randomized to a 12-week Kirtan Kriya meditation (KK) or music listening (ML) program and asked to practice 12 minutes/day...
October 11, 2018: Journal of Alzheimer's Disease: JAD
Kevin Mullane, Michael Williams
Compounds targeted for the treatment of Alzheimer's Disease (AD) have consistently failed in clinical trials despite evidence for target engagement and pharmacodynamic activity. This questions the relevance of compounds acting at current AD drug targets - the majority of which reflect the seminal amyloid and, to a far lesser extent, tau hypotheses - and limitations in understanding AD causality as distinct from general dementia. The preeminence of amyloid and tau led to many alternative approaches to AD therapeutics being ignored or underfunded to the extent that their causal versus contributory role in AD remains unknown...
September 28, 2018: Biochemical Pharmacology
Nanna W Dombernowsky, Ian Law, Steen G Hasselbalch
Dementia with Lewy bodies (DLB) is a common type of dementia. The core clinical symptoms are visual hallucinations, fluctuating cognition with pronounced variations in attention, REM sleep behaviour disorder and parkinsonism. Early diagnosis and differentiation from Alzheimer's disease can be challenging, especially when the core clinical symptoms are modest or only partly present. In this case report, we describe two patients, who had unexplained loss of consciousness and visual hallucinations, which were the early signs of DLB in absence of parkinsonism...
September 17, 2018: Ugeskrift for Laeger
Andrée-Ann Baril, Julie Carrier, Alexandre Lafrenière, Simon Warby, Judes Poirier, Ricardo S Osorio, Najib Ayas, Marie-Pierre Dubé, Dominique Petit, Nadia Gosselin
Epidemiologic and mechanistic evidence is increasingly supporting the notion that obstructive sleep apnea is a risk factor for dementia. Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decision-making. Cerebrospinal fluid and blood biomarkers obtained through genomic, proteomic and metabolomic approaches are improving the ability to predict incident dementia. Therefore, fluid biomarkers have the potential to predict vulnerability to neurodegeneration in individuals with obstructive sleep apnea, as well as deepen our understanding of pathophysiological processes linking obstructive sleep apnea and dementia...
August 13, 2018: Sleep Medicine Reviews
Alexander J Ehrenberg, Claudia K Suemoto, Elisa de Paula França Resende, Cathrine Petersen, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Renata Eloah de Lucena Ferretti-Rebustini, Michelle You, Jun Oh, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Joel H Kramer, Jennifer R Gatchel, Lea T Grinberg
Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease (AD)-related pathology may open avenues for effective treatments. Here, we investigate the odds of developing neuropsychiatric symptoms across increasing burdens of neurofibrillary tangle and amyloid-β pathology. Participants who passed away between 2004 and 2014 underwent comprehensive neuropathologic evaluation at the Biobank for Aging Studies from the Faculty of Medicine at the University of São Paulo. Postmortem interviews with reliable informants were used to collect information regarding neuropsychiatric and cognitive status...
September 7, 2018: Journal of Alzheimer's Disease: JAD
Ahmet Turan Isik, Pinar Soysal, Marco Solmi, Nicola Veronese
OBJECTIVE: The aim of this review is to make a state of the art of the potential influence of neuropsychiatric symptoms (NPs) on caregiver stress and vice versa. METHODS: We searched PubMed and Google Scholar for potential eligible articles. RESULTS: Patients with Alzheimer's disease (AD) usually need high levels of care in all activities of daily living, most of them provided by family members, friends, or informal caregivers. Caregivers have to cope with both age-related conditions and dementia-related factors...
September 10, 2018: International Journal of Geriatric Psychiatry
Andrew S P Lim, Chris Gaiteri, Lei Yu, Shahmir Sohail, Walter Swardfager, Shinya Tasaki, Julie A Schneider, Claire Paquet, Donald T Stuss, Mario Masellis, Sandra E Black, Jacques Hugon, Aron S Buchman, Lisa L Barnes, David A Bennett, Philip L De Jager
BACKGROUND: There are few data concerning the association between season and cognition and its neurobiological correlates in older persons-effects with important translational and therapeutic implications for the diagnosis and treatment of Alzheimer disease (AD). We aimed to measure these effects. METHODS AND FINDINGS: We analyzed data from 3,353 participants from 3 observational community-based cohort studies of older persons (the Rush Memory and Aging Project [MAP], the Religious Orders Study [ROS], and the Minority Aging Research Study [MARS]) and 2 observational memory-clinic-based cohort studies (Centre de Neurologie Cognitive [CNC] study at Lariboisière Hospital and the Sunnybrook Dementia Study [SDS])...
September 2018: PLoS Medicine
Nadia Gosselin, Andrée-Ann Baril, Ricardo S Osorio, Marta Kaminska, Julie Carrier
Obstructive sleep apnea causes intermittent hypoxia and sleep fragmentation and affects at least 20% of individuals after the age of 65. There is accumulating evidence that obstructive sleep apnea may impact brain structure and function. Recent cohort studies suggest that it is a risk factor for stroke, mild cognitive impairment and Alzheimer's disease. Because prevention through treatment of risk factors is currently the main intervention for reducing the incidence of dementia, how obstructive sleep apnea affects brain health and whether its treatment can slow neurodegeneration are relevant questions...
August 16, 2018: American Journal of Respiratory and Critical Care Medicine
Nicholas Bott, Shefali Kumar, Caitlyn Krebs, Jordan M Glenn, Erica N Madero, Jessie L Juusola
BACKGROUND: A growing body of evidence supports the use of lifestyle interventions for preventing or delaying the onset of Alzheimer disease and other forms of dementia in at-risk individuals. The development of internet-delivered programs would increase the scalability and reach of these interventions, but requires validation to ensure similar effectiveness to brick-and-mortar options. OBJECTIVE: We describe the study design, recruitment process, and baseline participant characteristics of the sample in the Virtual Cognitive Health (VC Health) study...
August 13, 2018: JMIR Research Protocols
Anastasia Bougea, Leonidas Stefanis, George P Paraskevas, Evangelia Emmanouilidou, Efthimia Efthymiopoulou, Kostas Vekrelis, Elisabeth Kapaki
INTRODUCTION: Given the overlapping of neuropathological, neurochemical and neuropsychiatric profiles of Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), their differential diagnosis is challenging. Specific neuropsychiatric features or biomarkers, such as cerebrospinal fluid (CSF) α-Synuclein (α-Syn), may aid in differential diagnosis. This study aims to compare the neuropsychiatric and CSF α-Syn profiles in these conditions, and to investigate the possible association between CSF α-Syn levels and neuropsychiatric symptoms...
August 6, 2018: Journal of Neurology
Hiroshige Fujishiro
Although dementia with Lewy bodies (DLB) is the second most common neurodegenerative disorder after Alzheimer disease, its diagnostic sensitivity in clinical practice is sub-optimal. In 2017, the DLB clinical diagnostic criteria were modified to include the additional core feature of REM sleep behavior disorder (RBD) and three new indicative biomarkers. With this revision, clinically probable DLB is represented by two or more core features (fluctuations, parkinsonism, visual hallucinations, or RBD) or by one core feature plus one indicative biomarker (low striatal dopamine transporter uptake, reduced cardiac [<sup>123</sup>I]-metaiodobenzylguanidine uptake, or REM sleep without atonia on polysomnography)...
August 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
Chuo-Yu Lee, Shih-Jung Cheng, Hui-Chi Lin, Yu-Lu Liao, Pei-Hao Chen
Dementia with Lewy bodies (DLB) is a complex, multisymptom disorder. When making decisions regarding the treatment of DLB, the patient's quality of life (QoL) should always be the main consideration. To our knowledge, this is the first review article focusing on the QoL in DLB patients. We searched the PubMed database using the keywords "quality of life" and "dementia with Lewy bodies." Previously, no specific instrument had been developed for assessing the QoL in DLB patients. Patients with DLB have a decreased QoL compared to patients with Alzheimer's disease, which is reportedly caused by several factors including level of independence in instrumental activities of daily living, whether the patient is living with the caregiver, apathy, delusion, and dysautonomia...
2018: Behavioural Neurology
Karen M Rose, John Lach, Yelena Perkhounkova, Jiaqi Gong, Sriram Raju Dandu, Robert Dickerson, Ifat Afrin Emi, Dawei Fan, Janet Specht, John Stankovic
Nighttime agitation, sleep disturbances, and urinary incontinence (UI) occur frequently in individuals with dementia and can add additional burden to family caregivers, although the co-occurrence of these symptoms is not well understood. The purpose of the current study was to determine the feasibility and acceptability of using passive body sensors in community-dwelling individuals with Alzheimer's disease (AD) by family caregivers and the correlates among these distressing symptoms. A single-group, descriptive design with convenience sampling of participants with AD and their family caregivers was undertaken to address the study aims...
August 1, 2018: Journal of Gerontological Nursing
Stefanie Lerche, Gerrit Machetanz, Benjamin Roeben, Isabel Wurster, Milan Zimmermann, Anna-Katharina von Thaler, Inga Liepelt-Scarfone, Gerhard W Eschweiler, Andreas Fallgatter, Florian Metzger, Walter Maetzler, Daniela Berg, Kathrin Brockmann
REM sleep behavior disorder (RBD) represents a major and relatively specific prodromal marker for synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies, and multisystem atrophy. Because PD patients primarily suffer from executive dysfunction, we hypothesized that individuals with RBD show an impairment in the nonamnestic executive domain rather than in amnestic domains. To address this question, we investigated a cohort of 1145 healthy elderly (183 with RBD) cross-sectionally and a subgroup of 544 of them longitudinally (144 with RBD) over 6 years...
October 2018: Neurobiology of Aging
Lisa C Bratzke, Beverly A Carlson, Chooza Moon, Roger L Brown, Rebecca L Koscik, Sterling C Johnson
INTRODUCTION: Several chronic illnesses have demonstrated relationships to cognitive decline in the context of aging. However, researchers have largely ignored the effects of multi-morbidity in the context of Alzheimer's disease and related dementias (ADRD) risk. The purpose of this study is to examine the relationship between multiple chronic conditions (MCC) and cognitive decline. METHODS: Latent class analysis (LCA) was completed to identify different subgroups of the 1285 participants from the Wisconsin Registry for Alzheimer's Prevention who were recognized based on their self-reported chronic illnesses...
August 2018: Applied Nursing Research: ANR
Aline Mendes, Sophie Tezenas du Montcel, Marcel Levy, Anne Bertrand, Marie-Odile Habert, Hugo Bertin, Bruno Dubois, Stéphane Epelbaum
BACKGROUND: Identifying comorbidities that influence preclinical Alzheimer's disease (AD) can give some insight into the AD early stages trajectories to allow new treatment venues and to guide public health systems to prevent subsequent dementia. OBJECTIVE: To examine the association of multimorbidity with AD neuroimaging markers in cognitively normal older adults. METHODS: This study had a cross-sectional design. Data regarding 14 comorbidities were obtained for all 318 adults aged 70-85 years, recruited from the community to an ongoing prospective monocentric cohort...
2018: Dementia and Geriatric Cognitive Disorders
Gaël Chételat, Antoine Lutz, Eider Arenaza-Urquijo, Fabienne Collette, Olga Klimecki, Natalie Marchant
Psycho-affective states or traits such as stress, depression, anxiety and neuroticism are known to affect sleep, cognition and mental health and well-being in aging populations and to be associated with increased risk for Alzheimer's disease (AD). Mental training for stress reduction and emotional and attentional regulation through meditation practice might help reduce these adverse factors. So far, studies on the impact of meditation practice on brain and cognition in aging are scarce and have limitations but the findings are encouraging, showing a positive effect of meditation training on cognition, especially on attention and memory, and on brain structure and function especially in frontal and limbic structures and insula...
June 22, 2018: Alzheimer's Research & Therapy
Kyra J Waligora, Mona N Bahouth, Hae-Ra Han
Background: More than 5.4 million informal caregivers (ICGs) in the United States care for persons with dementia (PWD). Failure of ICGs to incorporate self-care into their routine may lead to adverse health consequences. Caregivers and researchers need to understand the evidence around dementia ICGs' self-care practices. Purpose: To synthesize evidence on the self-care needs and behaviors of Alzheimer's and dementia ICGs and its research implications. Methods: PubMed, CINAHL, Scopus, and Web of Science were searched to conduct a systematic review of research...
June 21, 2018: Gerontologist
Koji Kasanuki, Keith A Josephs, Tanis J Ferman, Melissa E Murray, Shunsuke Koga, Takuya Konno, Nobutaka Sakae, Adam Parks, Ryan J Uitti, Jay A Van Gerpen, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson
OBJECTIVE: To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS). METHODS: In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex...
July 17, 2018: Neurology
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