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Alzheimer's Dementia Sleep

Leonie C P Banning, Inez H G B Ramakers, Kay Deckers, Frans R J Verhey, Pauline Aalten
OBJECTIVE: APOE status has been associated to affective symptoms in cognitively impaired subjects, with conflicting results. METHODS: Databases CINAHL, Embase, PsychINFO and PubMed were searched for studies evaluating APOE genotype with affective symptoms in MCI and AD dementia. Symptoms were meta-analyzed separately and possible sources of heterogeneity were examined. RESULTS: Fifty-three abstracts fulfilled the eligibility criteria. No association was found between the individual symptoms and APOE ε4 carriership or zygosity...
December 1, 2018: Neuroscience and Biobehavioral Reviews
Nienke Legdeur, Maryam Badissi, Stephen F Carter, Sophie de Crom, Aleid van de Kreeke, Ralph Vreeswijk, Marijke C Trappenburg, Mardien L Oudega, Huiberdina L Koek, Jos P van Campen, Carolina J P W Keijsers, Chinenye Amadi, Rainer Hinz, Mark F Gordon, Gerald Novak, Jana Podhorna, Erik Serné, Frank Verbraak, Maqsood Yaqub, Arjan Hillebrand, Alessandra Griffa, Neil Pendleton, Sophia E Kramer, Charlotte E Teunissen, Adriaan Lammertsma, Frederik Barkhof, Bart N M van Berckel, Philip Scheltens, Majon Muller, Andrea B Maier, Karl Herholz, Pieter Jelle Visser
BACKGROUND: The oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated protective factors for cognitive impairment in the oldest-old. The EMIF-AD 90+ Study aims to identify factors associated with resilience to cognitive impairment in the oldest-old. In this paper we reviewed previous studies on cognitive resilience in the oldest-old and described the design of the EMIF-AD 90+ Study...
November 26, 2018: BMC Geriatrics
Gemma Lombardi, Cristina Polito, Valentina Berti, Silvia Bagnoli, Benedetta Nacmias, Alberto Pupi, Sandro Sorbi
Bilingualism is an independent component of cognitive reserve that permits to delay dementia onset up to 5 years. We describe a case of a bilingual Italian man affected by mild cognitive impairment with high cognitive reserve that, despite the presence of multiple risk factors (ApoE ɛ4/ɛ4 genotype, older age, untreated Obstructive Sleep Apnea Syndrome, AD-like biomarker alterations) did not convert to Alzheimer's disease up to 5 years follow-up. The present case confirms the role of bilingualism as a strong protective factor for dementia, even in the occurrence of multiple risk factors...
November 17, 2018: Journal of Alzheimer's Disease: JAD
Kristine Yaffe, Deborah E Barnes, Dori Rosenberg, Sascha Dublin, Allison R Kaup, Evette J Ludman, Eric Vittinghoff, Carrie B Peltz, Anne D Renz, Kristin J Adams, Eric B Larson
This article describes the protocol for the Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT), a single-blind randomized pilot trial to test a personalized, pragmatic, multi-domain Alzheimer's disease (AD) risk reduction intervention in a US integrated healthcare delivery system. Study participants will be 200 higher-risk older adults (age 70-89 years with subjective cognitive complaints, low normal performance on cognitive screen, and ≥ two modifiable risk factors targeted by our intervention) who will be recruited from selected primary care clinics of Kaiser Permanente Washington, oversampling people with non-white race or Hispanic ethnicity...
November 23, 2018: Journal of Alzheimer's Disease: JAD
Yoko Higami, Miyae Yamakawa, Kazue Shigenobu, Kei Kamide, Kiyoko Makimoto
AIM: Sleep disturbances in patients with Alzheimer's disease have not been systematically evaluated, because sleep monitoring has proved difficult. Our goal was to quantitatively characterize sleep disturbances in patients with Alzheimer's disease. METHODS: The present study was a cross-sectional descriptive study, carried out in dementia care units in Japan. Participants were 63 patients with Alzheimer's disease (mean age 77.6 ± 8.0 years) with severe behavioral and psychological symptoms of dementia...
November 21, 2018: Geriatrics & Gerontology International
Penny Rapaport, Lucy Webster, Rossana Horsley, Simon D Kyle, Kirsi M Kinnunen, Brendan Hallam, James Pickett, Claudia Cooper, Colin A Espie, Gill Livingston
Many people living with dementia experience sleep disturbances yet there are currently no known effective, safe and acceptable treatments. Working with those affected by dementia to co-produce interventions is increasingly promoted to ensure that approaches are fit for purpose and meet the specific needs of target groups. Our aim here is to outline and reflect upon the co-production of Dementia RElAted Manual for Sleep; STrAtegies for RelaTives (DREAMS:START), an intervention to improve sleep for people living with dementia...
November 2018: Dementia
Claudio Liguori, Nicola Biagio Mercuri, Marzia Nuccetelli, Francesca Izzi, Sergio Bernardini, Fabio Placidi
BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia. It is characterized by a progressive deterioration of cognition, frequently associated with neuropsychiatric symptoms (NPS). Among NPS, sleep disturbances often affect AD patients. Orexinergic system dysregulation has been associated with sleep impairment in AD patients. OBJECTIVE: The present study investigated CSF orexin levels in AD patients and their relationship with both NPS, measured by the neuropsychiatric inventory (NPI), and sleep, measured via polysomnography...
2018: Journal of Alzheimer's Disease: JAD
Eduardo Spinedi, Daniel P Cardinali
<br>Alzheimer's disease (AD) is associated with altered eating behavior and metabolic disruption. Amyloid plaques and neurofilament tangles are observed in many hypothalamic nuclei from AD brains. Some of these areas (suprachiasmatic nuclei, lateral hypothalamic area) also play a role in regulation of the sleep/wake cycle and may explain the comorbidity of eating and sleep disorders observed in AD patients. Inadequate sleep increases the neurodegenerative process, e.g. the decrease of slow wave sleep impairs clearance of β-amyloid peptide (Aβ) and tau protein from cerebral interstitial fluid...
October 28, 2018: Neuroendocrinology
Jae Hoon Cho, Jeffrey D Suh, Kyung-Do Han, Jin-Hyung Jung, Heung Man Lee
STUDY OBJECTIVES: Numerous studies have found that obstructive sleep apnea (OSA) causes or exacerbates dementia, including Alzheimer disease and vascular dementia. However, the evidence is often conflicting. Moreover, no study has investigated the effect of surgical treatment for OSA on dementia. METHODS: This retrospective cohort study analyzed data from the Korea National Health Insurance Corporation. A total of 125,417 participants (age 40 years or older) with a new diagnosis of OSA between 2007 and 2014 were included...
October 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Jessica E Manousakis, Anna J Scovelle, Shantha M W Rajaratnam, Sharon L Naismith, Clare Anderson
BACKGROUND: Increased sleep fragmentation and advanced circadian timing are hallmark phenotypes associated with increased age-related cognitive decline. Subjective cognitive decline (SCD) is considered a prodromal stage of neurodegeneration and dementia; however, little is known about how sleep and circadian timing impact on memory complaints in SCD. OBJECTIVE: To determine how sleep and circadian timing impact on memory complaint subtypes in older adults with SCD...
2018: Journal of Alzheimer's Disease: JAD
Kim E Innes, Terry Kit Selfe, Kathleen Brundage, Caitlin Montgomery, Sijin Wen, Sahiti Kandati, Hannah Bowles, Dharma Singh Khalsa, Zenzi Huysmans
BACKGROUND: Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels have emerged as possible predictors of cognitive decline and dementia. OBJECTIVE: To assess the: 1) effects of two 12-week relaxation programs on TL, TA, and Aβ levels in adults with subjective cognitive decline; and 2) relationship of biomarker changes to those in cognitive function, psychosocial status, and quality of life (QOL). METHODS: Participants were randomized to a 12-week Kirtan Kriya meditation (KK) or music listening (ML) program and asked to practice 12 minutes/day...
2018: Journal of Alzheimer's Disease: JAD
Kevin Mullane, Michael Williams
Compounds targeted for the treatment of Alzheimer's Disease (AD) have consistently failed in clinical trials despite evidence for target engagement and pharmacodynamic activity. This questions the relevance of compounds acting at current AD drug targets - the majority of which reflect the seminal amyloid and, to a far lesser extent, tau hypotheses - and limitations in understanding AD causality as distinct from general dementia. The preeminence of amyloid and tau led to many alternative approaches to AD therapeutics being ignored or underfunded to the extent that their causal versus contributory role in AD remains unknown...
September 29, 2018: Biochemical Pharmacology
Nanna W Dombernowsky, Ian Law, Steen G Hasselbalch
Dementia with Lewy bodies (DLB) is a common type of dementia. The core clinical symptoms are visual hallucinations, fluctuating cognition with pronounced variations in attention, REM sleep behaviour disorder and parkinsonism. Early diagnosis and differentiation from Alzheimer's disease can be challenging, especially when the core clinical symptoms are modest or only partly present. In this case report, we describe two patients, who had unexplained loss of consciousness and visual hallucinations, which were the early signs of DLB in absence of parkinsonism...
September 17, 2018: Ugeskrift for Laeger
Andrée-Ann Baril, Julie Carrier, Alexandre Lafrenière, Simon Warby, Judes Poirier, Ricardo S Osorio, Najib Ayas, Marie-Pierre Dubé, Dominique Petit, Nadia Gosselin
Epidemiologic and mechanistic evidence is increasingly supporting the notion that obstructive sleep apnea is a risk factor for dementia. Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decision-making. Cerebrospinal fluid and blood biomarkers obtained through genomic, proteomic and metabolomic approaches are improving the ability to predict incident dementia. Therefore, fluid biomarkers have the potential to predict vulnerability to neurodegeneration in individuals with obstructive sleep apnea, as well as deepen our understanding of pathophysiological processes linking obstructive sleep apnea and dementia...
December 2018: Sleep Medicine Reviews
Alexander J Ehrenberg, Claudia K Suemoto, Elisa de Paula França Resende, Cathrine Petersen, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, Renata Eloah de Lucena Ferretti-Rebustini, Michelle You, Jun Oh, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Joel H Kramer, Jennifer R Gatchel, Lea T Grinberg
Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease (AD)-related pathology may open avenues for effective treatments. Here, we investigate the odds of developing neuropsychiatric symptoms across increasing burdens of neurofibrillary tangle and amyloid-β pathology. Participants who passed away between 2004 and 2014 underwent comprehensive neuropathologic evaluation at the Biobank for Aging Studies from the Faculty of Medicine at the University of São Paulo. Postmortem interviews with reliable informants were used to collect information regarding neuropsychiatric and cognitive status...
2018: Journal of Alzheimer's Disease: JAD
Ahmet Turan Isik, Pinar Soysal, Marco Solmi, Nicola Veronese
OBJECTIVE: The aim of this review is to make a state of the art of the potential influence of neuropsychiatric symptoms (NPs) on caregiver stress and vice versa. METHODS: We searched PubMed and Google Scholar for potential eligible articles. RESULTS: Patients with Alzheimer's disease (AD) usually need high levels of care in all activities of daily living, most of them provided by family members, friends, or informal caregivers. Caregivers have to cope with both age-related conditions and dementia-related factors...
September 10, 2018: International Journal of Geriatric Psychiatry
Andrew S P Lim, Chris Gaiteri, Lei Yu, Shahmir Sohail, Walter Swardfager, Shinya Tasaki, Julie A Schneider, Claire Paquet, Donald T Stuss, Mario Masellis, Sandra E Black, Jacques Hugon, Aron S Buchman, Lisa L Barnes, David A Bennett, Philip L De Jager
BACKGROUND: There are few data concerning the association between season and cognition and its neurobiological correlates in older persons-effects with important translational and therapeutic implications for the diagnosis and treatment of Alzheimer disease (AD). We aimed to measure these effects. METHODS AND FINDINGS: We analyzed data from 3,353 participants from 3 observational community-based cohort studies of older persons (the Rush Memory and Aging Project [MAP], the Religious Orders Study [ROS], and the Minority Aging Research Study [MARS]) and 2 observational memory-clinic-based cohort studies (Centre de Neurologie Cognitive [CNC] study at Lariboisière Hospital and the Sunnybrook Dementia Study [SDS])...
September 2018: PLoS Medicine
Nadia Gosselin, Andrée-Ann Baril, Ricardo S Osorio, Marta Kaminska, Julie Carrier
Obstructive sleep apnea causes intermittent hypoxia and sleep fragmentation and affects at least 20% of individuals after the age of 65. There is accumulating evidence that obstructive sleep apnea may impact brain structure and function. Recent cohort studies suggest that it is a risk factor for stroke, mild cognitive impairment and Alzheimer's disease. Because prevention through treatment of risk factors is currently the main intervention for reducing the incidence of dementia, how obstructive sleep apnea affects brain health and whether its treatment can slow neurodegeneration are relevant questions...
August 16, 2018: American Journal of Respiratory and Critical Care Medicine
Nicholas Bott, Shefali Kumar, Caitlyn Krebs, Jordan M Glenn, Erica N Madero, Jessie L Juusola
BACKGROUND: A growing body of evidence supports the use of lifestyle interventions for preventing or delaying the onset of Alzheimer disease and other forms of dementia in at-risk individuals. The development of internet-delivered programs would increase the scalability and reach of these interventions, but requires validation to ensure similar effectiveness to brick-and-mortar options. OBJECTIVE: We describe the study design, recruitment process, and baseline participant characteristics of the sample in the Virtual Cognitive Health (VC Health) study...
August 13, 2018: JMIR Research Protocols
Anastasia Bougea, Leonidas Stefanis, George P Paraskevas, Evangelia Emmanouilidou, Efthimia Efthymiopoulou, Kostas Vekrelis, Elisabeth Kapaki
INTRODUCTION: Given the overlapping of neuropathological, neurochemical and neuropsychiatric profiles of Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), their differential diagnosis is challenging. Specific neuropsychiatric features or biomarkers, such as cerebrospinal fluid (CSF) α-Synuclein (α-Syn), may aid in differential diagnosis. This study aims to compare the neuropsychiatric and CSF α-Syn profiles in these conditions, and to investigate the possible association between CSF α-Syn levels and neuropsychiatric symptoms...
October 2018: Journal of Neurology
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